XVIII-CENTURY MEDICINE personality. He was intolerant of criticism, blunt in manner, and appears to have deserved the criticism of Boerhaave, who called him " the sour metaphysician." Nevertheless he served his generation well by provoking some degree of reaction against materialism, and by suggesting that the psychical aspect of disease should not be neglected. Had he lived to-day, he would probably have become a distinguished psychiatrist. JOSEPH BARTHEZ of Montpellier (1734-1806), who was born in the year of Stahl's death, recognizing the difficulty of champion- ing the claim of " soul" or of " body," introduced a dominant force which he alleged was neither the one nor the other. This he called the " vital principle." The idea made little progress, as it was obvious that this was merely another name for the life force which had eluded so many inquirers. " Vitalism " pre- sented no advantage over animism. Often associated with the name of Stahl in medical history is that of his fellow-professor at Halle, FRIEDRIGH HOFFMANN (1660- 1742). Nevertheless Stahl and Hoffmann had little in common. A man of kindly and urbane temperament, Hoffmann had all the qualities of the successful physician. Not only did he conduct a large practice, but he also gained a great reputation as a teacher. His system of medicine was based upon the belief that the universe was pervaded by a vital substance, " finer than all other matter, but not exactly spirit, soul, or mind," and that this subtle some- thing maintained the body in a state of tonic equilibrium. In Hoffinann's view, disease resulted from excess or deficiency of " tonus." Excess of tonus, or spasm, caused acute disease, while lack of it, or atony, caused chronic disease. Treatment, therefore, consisted for the most part in the administration of sedatives for the former condition, and tonics for the latter. Even the modern patient still demands " a tonic " from his doctor. The fact that Hoffmann employed and sold certain secret remedies need not detract from his good name, as this was a universal practice at the time. One of his preparations, Hoff- mann's anodyne (Spiritus Aetheris Go)1 still survives, although his extensive work, Medicina rationalis systematic^ in nine volumes, 1718-40, has long since been forgotten. 1 A. C. Wootton, Chronicles ofPharmaey, 2 volsv 1910 217