512 A TEXT-BOOK OF VETERINARY OBSTETBICS the skin clings to the bones; and though debility k present oestrus may occur far more frequently than in health, yet fecundation is not possible. Marasmus sets in with febrile attacks at intervals ; and though recovery is still possible, by skilful treatment and long-continued nursing, yet death is only too often the sequel. In the smaller animals, distension of the abdomen becomes very marked, and resembles ascites. From the latter it may be distinguished because the distension is more lateral, the swelling can be defined by manipulation, and no fluctuation can be made out on palpation as in ascites. The diagnosis is made by the vaginal discharge and by rectal examination in the large animals and abdominal manipulation in the bitch and cat. The editor has observed a number of cases of sudden death in the bitch where pyometra was the only lesion found on post-mortem examination. Treatment.—"When the os is closed, it must be dilated by manipulation. This operation may occupy several hours. The pus present in the uterus must be siphoned off, and the uterus irrigated daily with any of the antiseptic injections recommended for acute metritis, such as potassium perman- ganate, carbolic acid, corrosive sublimate (1 to 3,000). The os must be kept open by plugging with gauze. An antiseptic suppository should be introduced into the uterus. Williams recommends iodoform, or a solution containing carbolic acid 1 drachm, tannin 1 ounce, glycerine 4 ounces, and tepid water 1 pint, for the mare. Hobday has used vaginal injections of hydrastis canadensis with success, giving the same drug also by the mouth. Internally, tonics and antiseptics must be administered, such as nux vomica, iron and copper sulphate, potassium iodide. Good results have recently been claimed in the treatment of the condition in the bitch by the administration of pituitrin. Hobday recommends doses of 1 to 2 c.c. given hypodermically at intervals of three days until the vaginal discharge has ceased. In the bitch, because of the difficulty of giving intra-uterine injections, the best treatment consists of total extirpation of the uterus (hysterectomy).