THE GERM-CELLS 131 need endowing with properties unlike those of all other organic agents." " Thus, there is no warrant for the assumption that sperm-cells and germ-cells possess powers fundamentally unlike those of other cells." To this it must be answered: (l) though sperm- cells and egg-cells, being living units, cannot be "fundamentally unlike" other living units, such as ordinary body-cells, yet they may be very unlike them 5 (2) that the germ-cells are very unlike ordinary body-cells is shown by the fact that they can do what no single body-cell can do, build up a whole organism ; (3) so specific are germ-cells that in certain cases and in favourable conditions a small fraction of an egg, bereft of its own nucleus, may, if fertilised, develop into an entire and normal larva; (4) it is quite con- sistent with the idea of evolution that in lower organisms the contrast between body-cells and germ- cells should be less pronounced than in higher forms. But the fundamental answer is found when we inquire into the history of the germ-cells. In many cases, and the list is being added to, the future reproductive cells are segregated off at an early stage in embryonic development. Even before differentiation sets in, the future reproductive cells may be set apart from the body-forming cells. The latter develop in manifold variety into skin and nerve, muscle and blood, gut and gland; they differentiate, and may lose almost all protoplasmic likeness to the mother ovum. But the reproductive cells are set apart; they take no share in the differentiation, but remain virtually unchanged, continuing unaltered the protoplasmic tradition of the original fertilised ovum. After a while their rms are organs of low