310 PATHOGENIC BACTERIA. in advance of the time when the organism is expected to saturate the body with its toxic products. This, in brief, is the theory and practice of Pasteur's system of treating hydrophobia. It is exactly in keeping with the ideas of the present, and is most extraordinary in its reasonings and details when we remember that the first application of the method to human medicine was made October 26, 1885, nearly ten years before the time we began to understand the production and use of anti- toxins.