C. THE SEPTIC DISEASES. CHAPTER I. ANTHRAX. disease of cattle known as anthrax or ct splenic fever " is of infrequent occurrence in this country and in England. In France, Germany, Hungary, Russia, Persia, and the East Indian countries it is a dreaded and common malady which robs herdsmen of many of their valuable stock. Siberia perhaps suffers most, the disease being so exceedingly common and malignant as to deserve the name 'c Siberian pest.'' Certain local areas, such as the Tyrol and Auvergne, in which it seems to be constantly present, serve as distributing foci from which the disease spreads rapidly in summer, afflicting many animals, and ceasing its depredations only with the advent of winter. It seems to be distinctly a disease of the summer season. The animals most frequently affected are cows and sheep. Among our laboratory animals white mice, guinea-pigs, and rabbits are highly susceptible; dogs, cats, most birds, and amphibians are almost perfectly immune. White rats are infected with difficulty. Man is only slightly susceptible, the manifestation of the dis- ease as seen in the human species being different from the same disease in the lower animals in that it is usually a local affection—malignant carbuncle—and only at times gives rise to a general infection. Anthrax was one of the first of the specific diseases proven to be caused by a definite micro-organism. As early as 1849, Pollender discovered small rod-shaped bodies in the blood of animals suffering from anthrax, but the exact relation which they bore to the disease was not pointed out until 1863, when Davaine, by a series of interesting experiments, proved to most unbiased minds their etiological significance. The further confirmation 356