INSECTICIDES AXD FUNGICIDES 293 function in a normal way. Non-volatile insecticides in the form of powdered solids may function by sticking to certain body secretions, then being absorbed into the tissues. As examples of this class, borax and sodium fluoride are frequently used to exterminate cockroaches. The powder sticks to the body of the insect and is partly absorbed but it also acts as a stomach poison because some of it is usually licked off and swallowed by the animal. The vapor of white hellebore is insufficient to kill insects but Shafer has noted that rose slugs which come into contact with this insecticide gradually become numbed and fall from the leaves. This occurred even in cases where none of the insecticide had been eaten. It is concluded that the numbing effect is due to slight dissolving of the powder and surface absorption by the excretions, little if any of the insecticide passing through the cuticular covering, and that the cause of the final death of the insect is due more to drying and starving than to any other reason. Finally, the natural cells of some insects contain enzymes, the normal functioning of which is of the greatest importance to the well-being of the insect. The interference of the various insecticides with the activity of these enzymatic bodies is known to be serious and this may be the cause of the death of the insect in some cases. Preparation of Insecticides.—The internal poisons are usually prepared in considerable quantities and their preparation should be under chemical control. The contact and fungicide poisons are freshly prepared by the sprayer and their efficiency depends upon the composition and proportions of the ingredients. Ar- senic has been so universally used as an active internal poison for insects that the determination of this element is highly important. Free arsenous acid in solution has a destructive action on foliage, therefore it is necessary also to limit the per cent of arsenic in this form. The maximum quantity which is safe for foliage varies from 4 to 6 per cent. Mixing of Sprays.—The question of combining insecticides and fungicides for the control of orchard pests is important from the standpoint of saving time and money as well as from that of increasing the efficiency of the spray. Choosing the