(77 } NICOLAI STENONIS OPERA PHILOSOPHICA Ed ITED BY VILHELM MAAR At the Expense of the Carlsbergfond. Vol. I COPENHAGEN VILHELM TRYDE MCMX !> / 3 :\i\ Ql 80 , THIS EDITION ST OF NICOLAUS STENO'S SCIENTIFIC WORKS HAS BEE lcl\0 PRINTED IN 350 COPIES BY CHRISTIAN CHRISTENSEN V.I COPENHAGEN No. 126 DEC 8 w6s) CONTENTS OF VOLUME I Pige. LIFE AND WORKS OF NICOLAUS STENO I NOTES BY THE EDITOR XXIX I DE PRIMA DUCTUS SALIVALIS EXTERIORIS INVENTIONE 6. BILSI* ANIS EXPERIMENTS 1 II DE GLANDULIS ORIS & NOVIS INDE PRODEUNTIBUS SALIVAS VASIS 9 III VARIAL IN OCULIS & NASO OBSERVATIONES NOVA* &C 53 IV RESPONSIO AD VINDICIAS HEPATIS REDIVIVI 59 V DE GLANDULIS OCULORUM NOVISQVE EARUNDEM VASIS OBSER* VATIONES ANATOMICAL 75 VI DE NARIUM VASIS 91 VII SUDORUM ORIGO EX GLANDULIS. DE INSERTIONE & VALVULA LACTEI THORACICI & LYMPHATICORUM 99 VIII CUR NICOTIANS PULVIS OCULOS CLARIORES REDDAT. DE LAC* TEA GELATIN A OBSERVATIO 105 IX OBSERVATIONES ANATOMIC^ IN AVIBUS & CUNICULIS 113 X EX VARIORUM ANIMALIUM SECTIONIBUS HINC INDE FACTIS EX* CERPTAL OBSERVATIONES CIRCA MOTUM CORDIS AURICULA* RUMQVE &. VENAL CAVAL 121 XI DE VESICULIS IN PULMONE. ANATOME CUNICULI PRALGNANTIS. IN PULMONIBUS EXPERIMENTA. DE LACTEIS MAMMARUM. IN CYGNO OBSERVATIONES, &C 129 XII LYMPHATICORUM VARIETAS 137 XIII APOLOGIAS PRODROMUS, QVO DEMONSTRATUR, JUDICEM BLASIA* NUM & REI ANATOMICAL IMPERITUM ESSE, & AFFECTUUM SUO* RUM SERVUM 143 XIV NOVA MUSCULORUM & CORDIS FABRICA 155 XV DE MUSCULIS 6. GLANDULIS OBSERVATIONUM SPECIMEN 161 XVI DE ANATOME RAJAL EPISTOLA 193 XVII DE VITELLI IN INTESTINA PULLI TRANSITU EPISTOLA 209 NOTES 219 LIFE AND WORKS OF NICOLAUS STENO I ICOLAUS STENO ° was born in Copenhagen, the capital of Denmark, in 1638. His father was a well* to*do and intelligent tradesman of a respectable fa* mily, who in his capacity of jeweller did much work for the Danish King, Christian IV. When a boy Steno was of delicate health, and he himself relates how he would much rather listen to the discourse of grown*up people, than play with children of his own age. He received a liberal education, and in the grammar*school, which he frequented, he had, besides the headmaster Jergen Eilersen (Geovgius Hilavius) several able teachers, among whom was the young and clever, later on so well*known Ole Borch (Olaus Borrichius). The latter was deeply interested in medicine and natural science, espe* cially chemistry, to the study of which he made valuable contribu* tions; at the same time he was a prominent philologist, and was early appointed Professor at the University of Copenhagen. He spent some time in Holland, where he met with Steno, who often mentions him in his Treatises and Letters, and with whom he always remained on intimate terms. In 1656 Steno entered the University of his native town, where he began to study medicine in connection with the related branches of natural science. At the University of Copenhagen these studies were at this period pursued with great zeal and ability by a series of great scholars, the members of a few prominent families. Among the most renowned, some of whom, however, were dead at the time of Steno's entering upon his studies, may be mentioned the physical philosopher Jacob Finke; the astronomer Christen Longomontanus, the pupil and co-operator of Tycho Brahe; and the physicians Casper Bar= ') The Danish form of this name is Niels Steensen, while the latinized form, generally used by its owner, was Nicolaus Stenonis. The form Stenonius also frequently occurs as well as the French Stenon and the Italian Stenone. The form usually adopted in our days is Sfeno, which is due to the erroneous conception that Stenonis was really the genitive case of a name Steno. Copenha* gen 1638 -1660. II LIFE AND WORKS OF NICOLAUS STENO tholin the elder, Ole Worm andjergen Fuiren, to which list must still be added, perhaps as the most celebrated of them all, the physician and anatomist, Thomas Bartholin, the son of Casper Bartholin; also Simon Paulli, the anatomist, called in from Rostock, who eventually gave himself up to botanical studies; and finally, besides several others, the abovesmentioned Ole Borch. Steno's studies at the University were anything but quiet and regu* lar. Denmark was at that time at war with Sweden, and Copenhagen was being besieged by the Swedish King, Carl X Gustaf. The students of the University distinguished themselves by the way in which they took part in the defence of the city, but lectures at the University were partly, and for a time altogether, suspended. Before the official conclusion of peace, Steno, in accordance with the prevailing custom of the times, went abroad to continue his stu« Amster= dies at foreign universities. He first visited Amsterdam, to where he dam 1660. had been supplied with letters of introduction by Thomas Bartholin. The latter had already long been enjoying a European reputation, and through his travels abroad and his extensive correspondence, f>artly published later on, he was in close contact with the world of earning of those days. In spite of his great credulity, which credulity often led him astray, and in spite of having to share the honour of his one great discovery, viz. that of the lymphatic vessels, as well with Michael Lyser, his prosector, as with Olof Rudbeck of Upsala, this re* markable man had yet founded a great school and had besides in various ways given a vigorous impetus to the scientific life of his own country. At an early period he had recognized Steno's intellectual gifts, and he always estimated him according to his merits. He recom* mended Steno to his friend and relative, Gerard Blaes, a well*known scholar of those days, Professor at the High School of Amsterdam (Athenxum), as well as Director of the Town Hospital (Het Gasthuis). Blaes invited Steno to his house, and with him Steno lived during the four months he spent in Amsterdam. Though only of short duration this stay was nevertheless of the greatest importance to Steno, not only because of the general impres* sions which he received through living in a great centre of civiliza* tion, such as Amsterdam was in those days, but also because he be* came personally acquainted with men of great learning and culture, among whom were the two renowned physicians, Paulus Barbette and Willem Piso, but especially Swammerdam, who was shortly afterwards to acquire such universal fame. These four months which Steno spent in Amsterdam, however, derived their chief importance from the fact that, on April 7, 1660, he made his first anatomical discovery, in that he found the parotid duct, called after him ductus Stenonianus. Though this discovery beyond all doubt is due to Steno, Blaes neverthe* LIFE AND WORKS OF NICOLAUS STENO III less attempted to appropriate it, and Steno, who had already spoken of it as his own, thought himself branded as an imposter, and for the sake of his honour felt obliged to vindicate himself. This caused a bitter controversy, which lasted for the next three years. It has been so thoroughly discussed by Gosch that there is no reason to go into details about it here. The unequality of the contest will at first sight be apparent to anybody: on one side the highly respected professor with his numerous, influential friends ; on the other side the unknown foreign student, twenty *two years of age. And Blaes certainly made the most of all his advantages; he backed the controversy with the whole of his authority; he made use of testimonials from his relatives and students; nay, he even induced a professor in Utrecht, Nicolaas Hobo= ken, who had no qualifications whatsoever to act as judge in the mat* ter, to publish a pamphlet against Steno, which contained nothing but loose assertions, accusations and insults. To this Steno replied in a manner which reflected the greatest honour upon himself. He never swerved from actual facts, but proved in a tranquil and objective man* ner that he was right and Blaes was wrong; and though there is no doubt that he was deeply hurt by Blaes' accusations, he never for a mo* ment let himself be carried away to any harsh or offensive remark. The controversy ended at last with a kind of reconciliation : Steno at the request of his friends left a final, decisive pamphlet against Blaes un* published, and the latter on his side one day received Steno in his house. It is worth while noticing that Steno in reality was not the first observer of the parotid duct, which had, in fact, been found as early as 1655 by Needham, who, however, did not publish his discovery till 1667. While this was going on, Steno was no longer in Amsterdam. Af* ter a stay which had, as mentioned above, only lasted four months, he left for Leyden, where he carried on his studies under Sylvius and Leyden van Home. Franciscus de la Boe Sylvius, an able physician and clinicist 1660-1664. who demonstrated patients to his students, was of great importance in the development of the science of chemistry, especially that of physiological chemistry, as well as in the study of the brain and the glands. His talents, his catching energy, his enthusiasm and his power of expressing himself clearly, as well as his many amiable qualities made a strong impression upon Steno, which is evident from the frequent mention he makes of Sylvius, even many years af* terwards. With Sylvius as well as with his other teacher, van Home, a celebrated surgeon and anatomist, Steno was at that time most inti* mately connected. The fact is that all the important discoveries, which Steno made during his stay of nearly four years in Leyden, had al* ready secured him many friends and admirers. He was admired as an able dissector, but still more for his capability of making new ob* IV LIFE AND WORKS OF NICOLAUS STENO servations, though perhaps most of all for his power of drawing sound, far*reaching, often ingenious conclusions from the observa* tions made; while at the same time he was loved for his modesty, his kindness, his upright way of thinking and his candour. Besides these two teachers of his and Swammerdam, who had also gone to Leyden, there were other well*known scholars, who belonged to Steno's most intimate circle. Of the latter may be mentioned his former teacher, now his friend, Ole Borch, who made a long stay in Leyden, and Matthias Jacobxus, a young Dane of the same age as Steno, the son of Jacob Matthiesen, who after having been professor in Copenhagen had been made Bishop of Aarhus in Jutland. In Ley* den Steno also made the acquaintance of one more country*man, which acquaintance, though at the time it seemed only temporary, was later on to be renewed under quite different circumstances. This country* man of Steno's was Peter Schumacher, who was then merely a young student, but who was afterwards to become the famous and unhappy High Chancellor of Denmark, Count Griffenfeldt. Among the Dutch scholars with whom Steno was most in contact during his stay in Ley* den, must be mentioned the highly gifted Jacob Golius, who besides being an able mathematician was a great traveller, known for his knowledge of Arabian, Turkish and Persian. He was Professor of Arabian and Mathematics in Leyden, and, no doubt, it was to him that Steno essentially owed his knowledge of languages, for instance Arabian, as well as of mathematics, which branch of science attracted Steno so much that, for a time, he thought of devoting himself ex* clusively to the study of mathematics, or more particularly of geo* metry. Finally we may mention Steno's intimate friendship with Benedict Spinoza, who during this period was living outside Leyden in Rijnsburg, but the religious views of the two men diverging more and more this friendship was destined to be of no long du* ration. The many notable men, who during these years were connected with Steno by ties of friendship, were however not the only factors contributing towards his development; of great importance were also those, who acted as his scientific, sometimes even his personal, ad* versaries. Among these Blaes plays the most prominent part, and Steno later on looked upon his controversy with Blaes as a link in his religious development. Besides him some others must also be mentioned: Bils, Deusing and Everaerts. — Lodevijk de Bils was a well* to*do, but not very cultured amateur anatomist, who at that time en* joyed a great reputation, chiefly because he pretended to have found a way of embalming dead bodies so as to keep them for ever in a perfect state of preservation, for which discovery he demanded the sum of 150,000 florins. He also made believe that he had a trick of LIFE AND WORKS OF NICOLAUS STENO V his own, by which he was able to perform vivisections without bleed* ing. Steno spent much time — too much time in our opinion — to prove the incorrectness of the assertions of Bils' and of the theories set forth by him concerning the flow and function of the chyle and the lymph. — As a follower and defender of Bils may be men* tioned Deusing, a learned professor of Groningen, known for his passion for writing as well as for his quarrelsomeness, who though he himself is said never to have made a single anatomical observation — in fact he was more of a philologist — yet published a treatise in defence of Bils, directed against Steno. — And lastly Bils found an* other advocate, and Steno another adversary, in Anthony Everaerts (Everardi), a pupil of Deusing and a physician in Middelburg. One phase of Dutch mental life, the phase, perhaps, which made the strongest impression upon Steno and which became, indeed, of the greatest importance to him later on, was the interest everybody took in religious matters. Contrary to nearly all other countries Hoi* land at that time enjoyed full religious liberty, and its inhabitants belonged to very different creeds and denominations. Steno, who was himself a Lutherian, had received his education in a country, where all the inhabitants were of the same faith, and where dissenting opi* nions were scarcely tolerated. It is unquestionable that these circum* stances, which made Holland so different from his native country, together with his constant coming into contact with people of various creeds left their mark upon Steno's earnest, religious mind and called forth many new reflections upon religious matters. Family*affairs compelled Steno to return to Copenhagen in the Copenha= spring of 1664. His step*father had recently died, and his mother, gen 1664. who was dangerously ill, died shortly afterwards. Even at this early period Steno enjoyed a great reputation in his native town, and one of his principal works, which appeared about this time in Copen* hagen and the same year in Amsterdam, was dedicated to Frederik III, the King of Denmark, to whom Steno at an earlier date had been warmly recommended by Thomas Bartholin. There was just then a very good opportunity of connecting Steno with the University of Copenhagen, and he himself surely expected to become a professor; but Bartholin, who otherwise took a very warm interest in the success and progress of his branch of science, was at the same time of the opinion — in other cases as it seems quite justly — that the best way of promoting it was by making members of his own family occupy the public positions. So the professorship was not given to Steno, but to Bartholin's nephew, the abowe*mentioned Matthias J acobxus. This injustice was a severe blow to Steno; and in the autumn of the same year he left Copenhagen. By Amsterdam and Cologne, where he had a conversation with a VI LIFE AND WORKS OF NICOLAUS STENO Jesuit concerning Protestantism and Catholicism, which revived his Paris 1664 interest in religious matters, Steno went to Paris, where his fame as -1665. a natural philosopher had gone before him, and where he was re* ceived with the greatest kindness and cordiality. Thevenot, the distin* guished supporter of the various branches of natural science and the founder of the French Academy, very kindly took care of him, helped him to get subjects for his anatomical and physiological researches, introduced him into the best circles of the capital and even invited him to live in his own house. Steno met there his friend Swammerdam, who also was a guest of Thevenot' s. Steno and Swammerdam were both of them amiable, straightforward and honest young men, equally enthusiastic about the study of natural science, and though Swam= merdam's interests were more particularly confined to the morpho* logy and biology of the lower animals, his studies being thus to some extent remote from what were the chief objects of Steno's re* searches, yet the two friends collaborated in two or three series of investigations. It was also in Paris, before an audience of interested scholars, who met at the house of Thevenot, that Steno delivered his famous discourse on the anatomy and physiology of the brain. — But in Paris, no more than in any other place, did he exclusively seek the scientific circles; he associated with many people of different interests, especially with catholic divines and people connected with them. Thus Steno is known to have been debating religious problems, among others with Elisabeth Rantzau (Deo sacvata Rantzovia), the wi* dow of Josias Rantzau, Marshal of France, who herself had taken the veil and founded a nunnery of the order of the Annunciata. After having visited serveral towns in France, about which voyage Florence little or nothing is known, Steno left for Italy, arriving in Florence in the summer of 1665. The letters of introduction, which he brought from Thevenot, his fame and prepossessing appearance made all doors open to him, and he soon felt quite at home in this city, which, as the years went on, he learned to love more and more. The Grand? Duke of Tuscany, Ferdinand II, in various ways attached Steno to his court, partly by securing him a good income that he might live without cares, partly by procuring him materials for investigation and the opportunity of carrying out his researches. These first years in Florence were the happiest years of Steno's life. He was honoured and liked, he felt that he was among friends, and he loved the city and country in which he was living. He eagerly took part in the social life of the town, felt happy and free of cares, and his most important scientific works appeared during this period. It would take too long to give a detailed account of all the eminent men, with whom Steno became acquainted, and to whom he at* tached himself during these years. We will only briefly, and with LIFE AND WORKS OF NICOLAUS STENO VII no definite plan, dwell upon those, who in one way or another were of importance to the development of Steno during this period. There was Vincenzio Viviani, the pupil and biographer of Galilei and closely connected with the Grand^Duke's court, who besides being a theorem tical mathematician of note spent his time, not only in scientific ex; periments, but also in works of practical purpose, the building of forts, the regulation of rivers cxc. He was an uncommonly gifted scholar, lively and enthusiastic, jealous and inconstant, but his friend* ship for Steno was sincere and unbroken. There was also Carlo Dati, who studied natural science and literature and was universally prai* sed for his kindness to all who came into contact with him. Further there was Francesco Redi, who later became Physician in Ordinary to the Grand?Duke; he distinguished himself as a poet as well as by his studies of natural science and languages, and was, by nature, a kind and modest man, loved by all. Of the Florentines, who in those days enjoyed a great reputation, the one who came in closest contact with Steno was, perhaps, Count Lorenzo Magalotti. The last scion of an ancient noble Roman family and educated by the Jesuits at Rome he was a young man of incredible natural gifts combined with a vivid interest in all branches of science, his knowledge ranging from astronomy to anatomy, from theology to mathematics and even embracing numerous languages, European as well as Oriental. He had an exceeding charm of manner, was am* bitious, a zealous Catholic and passionately attached to Steno. For a while he was the Secretary of the Accademia del Cimento, later on he was appointed the Ambassador of Cos/mo /// in Vienna. Among other scholars, whom Steno met and made friends with during these years, was Marcello Malpighi, the excellent anatomist, who, it is true, never resided in Florence itself, but with whom Steno nevertheless for a long time kept up a constant intercourse, which was all the more natural as the researches made by these two natural philosophers often touched one another. During these years, spent at the court of the Grand*Duke, Steno not only lived in Florence; he also accompanied his patron on his tours to various parts of Tuscany, which tours, among other things, gave Steno the opportunity of making those researches concerning the geology of the country, which more than anything else have contributed to his fame. But while engaged in these examinations and associating with friends, like himself interested in natural science, he was constantly brooding over the problem, which more and more took hold of him: the question of Protestantism versus Catholicism. It would carry us too far, if we here were to examine closely this side of Steno s development. We have already hinted at his natural readiness to take up this question, and how his stay in Holland and VIII LIFE AND WORKS OF NICOLAUS STENO Paris gave him ample opportunities for discussing religious problems. In Florence the same questions were, for many reasons, brought still nearer to him. Besides his above-mentioned friends, whose endeavours to win him over to Catholicism were perhaps only indirect, he had other friends of either sex, whose chief aim was to bring about his conversion. Among the latter, especially deserving to be mentioned, are Maria Flavia, an elderly nun of an ancient, distinguished Floren* tine family, and Lavinia Felice Cenami Avnolfini, married to Silvestvo Arnolfini, the Ambassador of Lucca in Florence. To the latter, who is described as a refined, intelligent and zealous lady, together with Pater Emilio Savignani the conversion of Steno was chiefly due; and in December 1667 he definitely renounced the protestant religion. Steno was surely perfectly honest and sincere in his change of faith, and also some of those, who worked for his conversion have, no doubt, acted solely in view of the salvation of his soul; but to many the most important feature of the case was the triumph it would mean to the Catholic Church, if it were to win over a man of Steno's reputation, and they naturally felt confident that he would wish and also be able to apply his great gifts in the service of the Church of Rome. On the very day when he renounced his protestant faith Steno received a letter, in which the Danish King summoned him home, holding forth at the same time the promise of a post at the Univer* sity of Copenhagen. Steno, however, did not set off at once; there was much to retain him in Italy; moreover he had to inform the Danish government of his change of faith in order to obtain liberty of worship. While waiting for the settling of this matter he composed a brief Pvodvomus on the contents of the great work, which he intended to write, and which was to be based upon the above*mentioned observations of the geological conditions of Tuscany. This brief, preliminary record is, no doubt, Steno's most ingenious work, abounding as it is with acute observations and with still more acute conclusions and gene; ralizations. It was finished in 1668 and published in 1669, but the great work, the forerunner of which it was intended to be, never appeared, perhaps because Steno felt too divided in mind. During the first years after his conversion his interests in religious and scien* tific matters are evidently at war, and though he makes some minor researches and writes a series of small papers, these works, which are able enough in themselves, are yet almost entirely lacking that inge* nuity, in which most of his earlier works abound. Rome and ** W3S thuS "0t Until a year after Sten0 nad been called back to Naples! 668. Copenhagen that he left Florence, and then only for Rome and Muranc. Naples, from where he set out northwards. In the spring of 1669 we Innsbruck, find Steno, first in Murano, then in Innsbruck; late in the summer he LIFE AND WORKS OF NICOLAUS STENO IX was in Vienna, afterwards in Prague, and in the spring of 1670 in Prague Amsterdam, where he remained till early in June. But Steno did not 1669. Am= feel at home there, as he had done before; his change of faith had s^-fnm estranged him from his former friends and at the same time involved him in various conflicts with the Protestants. Frederik HI, who had summoned Steno back to Denmark, had died in February in the same year, and this together with an invitation to go back to Florence, because Ferdinand II was dangerously ill, made Steno give up his in* tended voyage to Denmark and return to Florence instead. Ferdi= Florence nand II, however, had died before Steno' s return, but Cosimo HI, a 1670— great patron of all branches of science and moreover a deeply reli* *6'2- gious man, received him, if possible, in a still more friendly way than his father had done, encouraged him to carry out his intended geo* logical work, and provided him with employment by making him arrange the large collection of minerals in the Pitti Palace. This time Steno stayed in Florence for two years, though, as before, he travelled about a good deal, examining, for instance, in the summer of 1671 two grottos in the Alps at Gresta and Moncodine, but with the excep* tion of two short Letters to the Grand*Duke about his discoveries in these grottos no scientific works exist from the hands of Steno during these years. Early in 1672 Steno received a second summons home, worded in the same terms as the one he had received four years and a half ago. Steno obeyed the order and left for Copenhagen, where he arrived Copenha= in the course of the summer. The time of his return seemed in every Sen 1672— respect a favourable one. Anatomy had of late years been neglected l67*- at the University of Copenhagen, and it fell to Steno to re*open the Theatrum Anatomicum and make many anatomical demonstrations, private and public, which here too aroused the liveliest admiration in those interested in natural science. Besides, Thomas Bartholin just then commenced the publication of his famous periodical, the Acta Medica Et Philosophica Hafhiensia, in which Steno had a good opportunity of publishing his observations. But in one more respect the time of Steno' s return seemed a favourable one, as a more tolerant attitude towards the Catholics was beginning to make itself felt, espe* daily through the influence of Griffenfeldt. This change of attitude was, however, as yet not very strong in its results. Thus Steno could not become a professor at the University, for which reason he received the title of Anatomicus Regius, and though left in peace by most people he was attacked in a rough and reckless manner by some of his compatriots, so that his stay in his native town was anything but pleasant to him. At this period Steno's mind was more than ever di* vided between religion and science, and his publications consisted partly of replies to attacks directed against him from the Protestants, LIFE AND WORKS OF NICOLAUS STENO Florence 1674- 1677. Hanover 1677- 1680. partly of descriptions of some of those animals, which he had dis* sected, and, last not least, of the splendid address, which he delivered at the re*opening of the anatomical theatre. But he never published any descriptions of the majority of his dissections. Some of them were, it is true, described by others in the Acta Hafniensia, but many are only known through brief notes written down by Holger Jacobxus, the brother of Steno's above-mentioned friend, Matthias Jacobxus, at that time Steno's dearest pupil and later Professor at the University of Copenhagen. After this time no scientific work whatsoever appeared from the hands of Steno. At length the stay in Copenhagen became too painful to Steno; he sent in his resignation, and after it had been accepted, he immediately left the country. By way of Hanover, where he paid a visit to the Duke, Johann Friedvich, likewise a convert to Catholicism, he went to Amsterdam, and from there to Florence, where he arrived about Christmas, 1674, and where he became the tutor of the son oiCosimo III. He probably altogether abandoned the study of natural science, being now entirely absorbed in his own relation to religious problems, and occupying himself with the writing of theological tracts and pole* mical pamphlets, among which his well-known letter to Spinoza, to which the latter never replied. It may be said of this letter of Steno's, as well as of all his religious writings, that they have the same spon* taneity, the same subjectivity and the same general impression of being founded upon a direct observation of the phenomena, which we observed in his writings on natural science. But while these qualities made the strength of Steno the scientist, and to some extent also ot Steno the Catholic, they prevented Steno from ever becoming, what some ot his friends had hoped he would become, an eminent theo* logian. In the autumn of 1675 Steno finally took Holy Orders, and henceforward he devoted his life exclusively to the cause of the Roman Church, and met with an eversincreasing admiration in Florence, the sincerity ot his pious life being looked upon with general veneration. He often tried to convert foreign Protestants, who visited the city, in many cases not without success. But Steno went further in his de* mands upon himself, and more especially he blamed himself because, during the first years after his conversion, he had been devoting part of his time to other things besides the service of God and the Catho* lie Church. Two years after his return to Florence Steno was appointed Bishop of Titiopolis in partibus infidelium and Vicar Apostolic of Northern Germany and Scandinavia. He went to live in Hanover, the residence ot the above-mentioned Duke Johann Friedvich, where he worked zealously tor the cause of Catholicism, bringing about many conver* LIFE AND WORKS OF NICOLAUS STENO XI sions. He lived a very frugal life, spending all he could spare to help the poor, and sacrificing his time and his strength in the cause of reli* gion. In the early winter of 1679Johann Friedrich died, being succeeded by his Protestantic brother, Ernst August. It now became impossible for Steno to remain any longer in Hanover, and in the spring of 1680 he settled in Munster as the Suffragan Bishop of the Bishop of Mun* ster, Ferdinand, Baron von Furstenberg. His income was not so large as it had been in Hanover, so he sold all his property and lived still more frugally in order to be able to help the poor, especially those lately converted to Catholicism. He performed numerous divine sers vices, made troublesome journeys round the neighbourhood and fasted strictly. By his pious life he also here succeeded in impressing many people; the admiration for him increased, but with it the envy, and by his extreme zeal he made numerous enemies. When Steno had lived for three years in Munster, the Bishop died; so he left and went to Hamburgh, which likewise belonged to his vicariate. He lived there for two years, in the utmost poverty. He kept no servants, he fasted most of the days of the week and wore ragged and filthy clothes. He did nothing to live up to his rank, did not even wear his clerical suit and spent everything on the poor, working so ardently for the benefit of Catholicism that he made himself hated even by the Catholics, who threatened to cut off his ears and drive him from the town as a criminal. To further minister the cause of his Church Steno left Hamburgh for Schwerin, where he worked under circumstances, which were, if possible, still more distressing, and here he died in unspeakable mise* ry, forty*eight years old. The Grand* Duke of Tuscany had his body conveyed to Florence, where it was deposited in the crypt of St. Lorenzo. Munster 1680- 1683. Hamburgh 1683- 1685. Schwerin 1685- 1686. II As for the material, which Steno used as the basis of his researches, he was nearly always indebted to circumstances; he very seldom ap* pears to have chosen it of his own accord. Thus, in his early days in Holland he was reduced to dissect such animals, or parts of animals, which he could get in the cheapest and easiest way. Later on in Florence Steno generally made his examinations on animals, which the Grand*Duke thought curious and therefore sent to him; or he made his geological researches in parts, to where he came in the train of the Grand*Duke. Also during the two years, which Steno spent in Copenhagen as Anatomicus Regius, he again had to use the material, which chance offered to him. Partly because his material was gene* XII LIFE AND WORKS OF NICOLAUS STENO rally not of his own choosing and therefore in itself limited, partly because he was so frequently interrupted by external circumstances, Steno hardly ever pursued the problem, which had raised his interest, until he came so near solving it, as was at all possible; on the contrary he broke off his investigation of a problem, in some cases even several times, to return to it, when he had the opportunity of doing so. This accounts for the fact that so few of his publications are complete in themselves; they nearly always appeared as the continuations of previous works or as the beginnings of works to come. For that reason the contents of his writings will be analyzed in the following pages, not in the succession in which he published them, but accor* ding as the several parts of his publications are connected with one another by the nature of the questions he attempted to solve. It is a matter of course that Steno made many examinations and solved many problems, which are either of minor interest or were not directly connected with the questions, to which he more especially devoted himself. These latter can be divided into different groups, the most important of which are: The Glands, the Lymphatic System, the Heart, the Muscles, the Development of the Embryo, the Sexual Organs, the Fishes, and in the case of all these groups both the anatomical and physiological sides of the questions. There are, more* over, subjects which — only apparently, however — are remote from these: the Occurrence and Development of Fossils and Crystals, and the Origin of the Strata of the Earth. Before going into a detailed account of what were Steno's contribu* tions to the various groups in question, we will in a few words draw attention to some phases of his personality as a man of science, phases in which he differed from most of the scientist of his time. Not only in his ingenuity, which was greater, fresher and more spontaneous than that of the majority, did he surpass most of his contemporaries in the scientific world and, without exaggeration, inscribe his name among those of the greatest men of his day; not only on the strength of his unusual powers did he distinguish himself; it was perhaps above all through his scientific method. He asked his questions and gave his answers as a scientist of the twentieth century; and deeply religious though he was, he never for a moment introduced any super* natural element in his solutions of problems of natural science.0 And while the majority of his contemporaries were, before all, scholars, and, ' ) from about the time when Steno took Holy Orders his development retrograded, even as tar .is his way of looking at nature was concerned. In his chief geological work (De Solido Intra SoliJum &c.) when touching upon the questions of rock-crystals, gems, precious and base metals, he had exclusively dealt with their formation and occurrence, but when he later on mentioned these very things in a sermon, he merely considered them from a religious point of view, dwelling on how their symbolic meaning was to be looked upon by markind. See Stenonis Nicolai Opera Medic. I'aht. 36. Sermo XL in R. Bibliotcca Lauremiana in Florence. LIFE AND WORKS OF NICOLAUS STENO XIII because they relied so implicitly upon researches made by those who had gone before them, perhaps did not always make such observa* tions as were before their very eyes, Steno, together with the best of his age, Harvey, Sylvius, Borelli, Malpighi and Swammerdam, was first and foremost an observer and an experimentalist. He observed the phenomena in a calm, unprejudiced and natural manner and thus discovered what, because of their preconceived ideas, most of his con* temporaries had failed to see. The number of new and important discoveries, which are due to Steno, is exceedingly great, and yet we do not here find the full expression either of his talent or of his sig* nificance. His genius reveals itself in the conclusions, which he draws from his discoveries, and in the generalizations which he makes. His conclusions are not only astonishing by their number, but still more by their soundness and clearness, and yet perhaps most of all admirable by their correctness and their scope, being such that in some cases they have not been fully appreciated until now, some two hundred and fifty years after their first appearance. Still there is one fact, which may perhaps help to throw further light on Steno's scientific per* sonality. At a time when most natural philosophers were, before all, physicians who looked upon natural science as the auxiliary of medicine, Steno himself never practised as a physician, and in his researches very rarely touched upon questions of a purely medical character. As mentioned above, Steno made his first discovery in Amsterdam The on April 7, 1660, when, being engaged in dissecting the head of a Glandsand sheep, he found the parotid duct. He called Blaes, who declared not to f iyTT _ know this duct and referred him to Wharton's work on the glands, pst*m c y~ published in 1656. As Steno neither here nor anywhere else found any positive information concerning this question, he continued his inve* stigations, and when shortly afterwards he went to Leyden, he showed his discovery to Sylvius and van Home, of whom the former was the first to find the parotid duct in man, the latter the first to demonstrate it in public, naming it after Steno. Through this first discovery of his Steno was led to study the ana* tomy and physiology of the glands and the lymphatic system. With regard to the glands Steno found in the first place that, what had hitherto been called the parotis, had really to be distinguished as two separate glands, of which the one secreted saliva through the duct found by him, and the other, an ordinary lymphatic gland, belonged to the lymphatic system. The former or these Steno classed among Sylvius' glandulx conglomerate, the latter among his glandulx conglo= batx. Furthermore he found that lymphatics were running from parotis conglomerata to parotis conglobata, and that another lymphatic vessel ran to a gland lying further below, his glandula communis, which received vessels also from a conglobate gland close to the sub* XIV LIFE AND WORKS OF NICOLAUS STENO maxillary gland, and from one of the same kind near the tonsils. Leading from this glandula communis was a fourth vessel, which to* gether with the other lymphatic vessels of the head opened into the vena cava at the place, where the jugular and axillary veins joined. This discovery was particularly interesting, because it showed that the lymph was conveyed from and not to the salivary glands, which was entirely at variance with the theory maintained by Bils and other of Steno's contemporaries, viz. that all the watery secretions and humors came from the thoracic duct. By this discovery Steno was involved in a controversy, not with Bils himself, but with Deusing, according to whom there were also other ways, in which the saliva could be se* creted, e.g., during excessive salivation, by the direct flowing down of the watery fluid of the brain into the cavity of the mouth through the apertures in the sphenoid bone. In his Dissertation Steno on the con? trary maintained that the arterial blood must be supposed to be of such a composition, as to be able to provide materials for the saliva, which, through the influence of the nerves, is secreted by the glands, by means of a process, which might be conceived as a temporary con* striction of the minute blood-vessels, in which manner a mechanical hindrance was made for the passage of the blood, which would then give off its more watery elements. — Against Everaerts who, as related above, likewise agreed with Bils in his view of the function of the lymph, being of the opinion that the lymph was conveyed direct to the mammae, to be there secreted as milk, Steno strongly asserted that the mammae were glands, and that they secreted milk in a manner analogous to that in which the salivary glands secreted the saliva. Steno's next researches concerning glands turned upon the lachry* mal glands. Even Wharton thought that the tears originated in the brain, from where they passed through the nerves, and that their flowing was due to a contraction of the brain, which occasioned the tears to be squeezed out, the tears subsequently passing through the nerves and through minute apertures in the eye, while the normal function of the lachrymal glands was to receive this humor from the nerves. Steno discovered the minute ducts of the lachrymal glands and imme* diately gave the one correct explanation of the secretion of the tears, when he maintained that the tears were the produce of the lachrymal glands and had their origin from the arterial blood through the in* fluence of the nerves on the glands; that the normal function of the lachrymal fluid was to keep the surface of the eye and eyelids smooth, and that this fluid afterwards passed through the puncta lacrymalia, the lacrymal canals, which have also first been observed by Steno, and through the naso*lachrymal ducts to the nose, which passage was only insufficient, when the lachrymal fluid was secreted in excessive abundance, e. g. during the process of weeping. Finally it is worth LIFE AND WORKS OF NICOLAUS STENO XV mentioning, that Steno in the same Treatise also asserted the cerumen to be a glandulous secretion, the glands in question lying between the skin and the cartilage. From the observation that the membranes of living animals are always humid, Steno was led to the theory that these membranes owe their humidity to glands; and setting to work to find glands in the nose, he discovered them in great abundance below the mucuous membrane. But besides this infinite number of small glands he dis* covered in the sheep and in the dog a large, separate conglomerate nasal gland, and furthermore remembering how channels had been provided for carrying away the fluid of the eye, Steno looked for a passage into the mouth, and found that the canales naso=palatini, some* times called canales Stenoniani, might serve this end in about the same manner as the anterior and posterior apertures of the cavity of the nose. As to the sweat Steno stated that it too was a glandular secretion. After a short interval, during which he occupied himself with other problems, Steno once more returned to the glands. He pointed out, how all the conglobate glands belong to the lymphatic system, looking upon the latter as consisting of conglobate glands and lymphatic ves* sels; but, erroneously, he also made those of the conglomerate glands, which secrete a watery fluid, together with their ducts, belong to this same system. As the essential results of his investigations up to this date Steno had established the following facts: 1) that all lymphatic vessels are connected with glands, the place of formation of the lymph being unknown; 2) that some of the lymphatics belonging to theconglome* rate glands, i. e. the excretory ducts of these glands, carry their secretion to the cavities of the body: the eyes, the ears, the nose, the mouth, the gullet, the throat ex c; 3) that the lymphatic vessels belonging to the conglobate glands, those now called the lymphatics, all carry their contents back to the venous system, either direct or through other conglobate glands; and 4) that all glands are organs to which and from which lymphatic vessels are running. On the strength of his researches, and in continuation of what has already been mentioned, Steno' further stated that not only do all conglomerate glands eva* cuate their fluids into the cavities of the body, but that wherever in the natural state a fluid is found on a surface, it has its origin from such glands. To those fluids he referred the following: 1) the fluid in the pericardium; 2) the sweat; 3) the fluid in the cavities of the brain; 4) the fluid on the surface of the organs of the thoracic and the abdominal cavities; and 5) the fluid by which the fetus is nourished, and which he supposed to be secreted in the placenta from the ma* ternal blood, chiefly because he had succeeded in separating, without bleeding, the fetus from the wall of the uterus of a cat. It was the XVI LIFE AND WORKS OF NICOLAUS STENO villi of the placenta and of the wall of the uterus, which he considered to be what he termed the eminentix glandulosx. Steno himself enume* rates his discoveries as follows: 1. Vas salivare exterius sive parotidum vas. 2. Vasa buccarum. 3. Vasa sublingvalia minora. 4. Vasa palati. 5. Meatus anterior e naribus in palatum. 6. Vasa epiglottidis. 7. Vas na= rium. 8. Vas narium ovibus peculiare. 9. Vix a palpebris in nares. 10. Vasa palpebrarum seu lacrymalia. 11. Vasa rajx superficiem exteriorem lubri= cantia. As regards two important, larger glands Steno has thus for the first time acknowledged them to be glands; he has discovered several excretory ducts and furthermore shown the existence of canals along which the various secretions are conveyed to the great cavities of the organism ; he has demonstrated that the secretion depends upon the supply of blood and upon the nervous system; and further, in the case of a number of small glands, he has shown the existence of these glands and explained their significance, pointing out how the fluid, which covers animal membranes, has not simply passed through these membranes, but has been secreted by numerous small glands of their own. In addition to the above-mentioned glands Steno in a fish, the ray, found the glands of the skin, which give to these animals their lubrici* ty. In the same specimen he also found the minute glands of the sto* mach and the intestine. It is also of interest to note — as appears from a MS. of the above-mentioned Holgerjacobxus — that at a dissection in 1673 Steno demonstrated those glands in the small intestine, which Peyer found in the same year, although he did not publish his dis* covery until four years later. The Heart By observing that the portion of the vena cava, which is nearest and the the heart, possessed independent contraction, which contraction, in Muscles, animals laid open by vivisection, continued long after the pulsation of the heart had ceased, Steno was led to a close investigation of the heart and its function. Even after Harvey's discovery of the circulation of the blood, the views concerning the importance of the heart to the organism were very much at variance, and numerous explanations of its function had, in reality, only this one thing in common that they were alike fanciful and alike far from being consistent with the actual facts. Steno was among the first, who reduced the existing chaos to clearness and order. In a Letter, dated Leyden ult. April. 1663, which he wrote to Thomas Bartholin, he told in few and simple words, that in his opi* nion the heart was a muscle and nothing but a muscle, and he ex* pressed the hope that he would soon be able to prove this statement: Qvod substantiam cordis spectat: evidenter, utopinor, demonstratum dabo, nihil in corde reperiri, qvod non reperiatur in musculo, nee in corde desi* derari, qvod in musculo invenitur, si ilia respexeris, qvx ad musculi faciunt LIFE AND WORKS OF NICOLAUS STENO XVII essentiatn, id qvod &■ de auviculis patebit verum, &c. Bartholin was far from admitting the correctness or Steno's view. Hippocrates himself, it is true, had already called the heart a muscle; but at Steno's time this view was completely overshadowed by that of Galen, and Steno was quite aware that his assertion would be received with the strongest opposition. He was likewise aware that it was not sufficient to make an assertion, but that a proof of its correctness might justly be claimed, and so he went the way of investigating the anatomy and physiology of the ordinary muscles, afterwards comparing the results of his researches with those attained by an examination of the anatomy and physiology of the heart. As early as in the year after he had written his Letter to Bartholin, Steno published his first Treatise on the muscles. He begins his Treatise by mentioning the anatomy and physiology of some particular muscles, first of all the respiratory ones; he corrects some errors in the current view of the latter, explains various pheno* mena, and gives their name to the levatores costarum muscles. Then he shows that the tongue does not, as was generally supposed, con? sist of a substance of its own, neither is it a gland, as Wharton among others maintained, but it is altogether made of muscular fibres, the course of which he describes. He also describes the two spirals of the muscular fibres, which cross in the oesophagus of the mammals. Pro* ceeding to speak of the general anatomy and physiology of the muscles, Steno furthermore says that the muscles do not, as was then generally supposed, consist of a parenchyma, caro, and muscular fibres, but are entirely made of fibres, to which must only be added arteries, veins, nerves and thin layers of fibrous tissue. The fibres, fibraz motrices, he again divides into fibrils, jibrillx minutissimx, and every muscular fibre, according to his opinion, is continued at either end of the muscle in a tendinous fibre, so that every one of the tendons belonging to a muscle has a number of tendinous fibres corresponding with the number of muscular fibres in the muscle. But when examining the heart Steno here also found nothing but muscular fibres (terminating in tendinous fibres), vessels, nerves and some connective tissue; and having found that also in the heart the function of these fibres was contraction, he concluded that the heart itself was a muscle and nothing but a muscle. Moreover Steno very carefully examined the course of the fibres in the heart, found the bending of the fibres at the apex and the different degree of obliquity of the different layers of fibres, which results were shortly afterwards carried further by Borelli. Finally Steno maintained that the fact of the contraction of the heart not being vo* luntary cannot be used as an argument against the heart's being a muscle, because many muscles, universally recognized as such, contract involuntarily. In thus showing what the heart is, Steno at the same time showed what it is not. He says himself: Non erit cor amplius sui XVIII LIFE AND WORKS OF NICOLAUS STENO generis substantia, adeoqve nee certx substantias, ut ignis, calidi innati, animx sedes, nee certi humovis, ut sangvinis, generator, nee spirituum qvorundam, vitalium puta, productor. Steno's interest in the general anatomy and physiology of the muscles visibly showed itself in a more extensive work on this subject, which work he himself seems to have valued highly, but which is, perhaps, now considered the weakest of his writings. The underlying idea, however, is in itself highly praiseworthy. His point of view was that all previous explanations as to the way in which the contraction of the muscles took place were very improbable and, which was still worse, very vague and obscure, and so he made it his aim to intro* duce the exact mathematical method into the investigation and ex* planation of the contraction of the muscles. Steno took a great interest in mathematics, in which branch of science he possessed considerable knowledge, and he was of the opinion that mathematics might be ap* plied in physiology and become of as great importance there, as it already was in other branches of science, e. g. astronomy. About the same time the same idea had led Borelli to occupy himself with bring* ing mathematics to bear upon the more mechanical side of the func* tion of the muscles. Steno wanted to utilize the mathematical laws to explain how the very contraction of the muscle took place. He justly looked upon the muscular fibre as the elementary part, the function of which, during the contraction, it was particularly important to become acquainted with. When in spite of much diligence and the most careful proofs he still did not arrive at a correct result, this was due to the following two errors. Firstly his starting*point was a wrong conception of the course of the muscular fibres. As has been already mentioned he thought that every muscular fibre at either end passed into a tendinous fibre, and he furthermore was of opinion that the course of the muscular, as well as that of the tendinous fibre were each of them rectilinear, forming an angle at the two places, where the muscular fibre became a tendinous one, neither of which suppositions have proved to agree with the actual facts. Secondly, he did not pay attention to the fact that every separate muscular fibre, when shortened by contraction, must needs become thicker, and that this in its turn must act on the whole figure of the muscle du* ring the contraction. Steno's interest in the special anatomy of the muscles displayed it* sell some years afterwards in his thorough description of the muscles ot an eagle, which he dissected during his stay in Copenhagen in 1673. Further we must mention the experiment, which still bears Steno's name, and which consisted in his ligaturing the descending aorta of a living animal, the consequence of which was a paralysis ofthe hind* legs, which paralysis ceased when the ligature was removed. LIFE AND WORKS OF NICOLAUS STENO XIX Finally Steno was the first to show that contraction of a muscle might occur not only by stimulation of its nerve, but also by stimu* lation of the muscle itself. At an early period Steno became interested in the study of the brain. The Brain. This is evident from a Letter to Thomas Bartholin, dated March 1663, in which he speaks about his having made numerous dissections of this organ, adding that what he found through these dissections was in every respect inconsistent with what Descartes taught about the brain. It is quite natural that Steno should become interested in the study of this organ. He was a pupil and friend of Sylvius, with whom he was almost in daily intercourse, and Descartes' De Homine, which had just appeared, had made an enormous sensation. It is easy to understand that Steno, when first mentioning Descartes, takes up a critical position towards this work, and more especially towards that part of it which deals with the brain. Steno clearly saw that nearly all the anatomical descriptions and physiological explanations of Des= cartes' were quite erroneous, and he was certainly at too close a range to be able to fully understand the idea of this particular work. The interest Steno took in the brain and its function might rationally lead one to suppose that he published his numerous observations on this organ. Strictly speaking this never happened, though during his stay in Paris he delivered a Discourse on the Brain before the as* sembly of learned men, who met at Thevenot's. This Discourse, which scarcely contains a single new observation, he left in Paris when leaving that city, and it was not published till four years after by a Paris bookseller. Steno seems purposely to leave the results of his own researches out of the question, and when this little work still ranks among his most important ones, it is because it contains in* structions concerning the study of the brain in particular, and the study of natural science in general, so intelligent and so sound that an anatomist like Winslev — who by the way was a relative and countryman of Steno's and like him a convertite to Catholicism — many years afterwards admits, que le seul Discours de feu M. Stenon sur I'Anatomie du Cerveau, a ete la source primitive &■ le modele general de toute ma conduite dansles travaux Anatomiques, and even goes so far as to reprint the whole of the Discourse in all editions of his famous Anatomy. Much of Steno's Discourse was, in fact, of so far«sighted a nature that it was not till many years after Winslev's time, partly not till our own age, that scientists were able to follow the instructions '"> given by Steno. It would carry us too far to give any detailed account of the Treatise; but in order to duly appreciate it, it will be necessary to remind the reader of the views current in the days of Steno concerning the brain and its function. The anatomical observations of the brain were still rather rudimentary, and its physiology was greatly based on XX LIFE AND WORKS OF NICOLAUS STENO sheer fancy. Any intimate knowledge of the more minute structure of the brain was, of course, quite out of the question ; it was hardly known that the substance of the brain at some places was made up of fibres, and there was an absolute ignorance of its being so everywhere. As to the different theories concerning its function, they were, really, only at variance as to the distribution of the mental faculties in the ventricles of the brain, and as to the part played by the animal spi* rits. Descartes and Willis were — each in his own way, and only partly — exceptions to this. That Steno did not estimate Descartes very highly as an anatomist has already been mentioned, nor was he greatly attracted by Willis. A sane observer like Steno could not help noticing that, although much in Willis was founded on correct ob* servations, much, on the other hand, rested on pretty similes and ana* logisms, which were to be taken as proofs. Characteristic of Steno s view of the physiology of the brain are the following words, with which his Discourse opens: Au lieu de vous promettre de contenter vostve curiosite, touchant I'Anatomie du Cexveau; ie vous fais icy une confession sincere & publique, que ie n'y connois rien. He then proceeds to demonstrate that all those self*relying men, who wrote on the brain, knew as little about the matter as he, or rather less, and that all the ideas, which they reckoned with, were only phantoms of their own imagination. Even the very animal spirits, the existence of which at that time was generally acknowledged, he mentions in the following way : On voit encore moins de certitude, sur le sujet des esprits animaux. Est=ce le sang? seroit=ce vne substance particuliere separee du chyle dans les glandes du mesentere? les serositez n'en seroienUelles points les sources ? II y en a qui les comparent a V esprit de vin, &■ Von peut douter si ce ne seroit point la matiere mesme de la lumiere. Steno, however, is not con* tent with pulling down the old building, he also gives advice, and very good advice indeed, as to the way in which a new building is to be erected. He speaks of the best ways of dissecting the brain; he de* scribes, how the skull is to be opened, the best means of acquiring trustworthy figures of the brain c\c. cxc. Of far greater importance, however, is his assertion that first of all an effort must be made to determine the course of the fibres in the brain, with which its function to all probability is closely connected. Moreover he says that valuable information might be obtained by comparing the brains of animals, from the lower to the higher, as well as by comparing dif* ferent stages of the development of the brain in the same animal, from the fetus to the adult individual. Furthermore he refers to all the in* formation to be had from the pathological anatomy of the brain; and finally he recommends experiments on living animals, the brain of which were to be examined, while drugs or poisons were either ad* ministered in the ordinary way, or applied direct to the brain. LIFE AND WORKS OF NICOLAUS STENO XXI Only twice more in his subsequent writings Steno touched upon the question of the brain. In his description of the dissection of a shark he particularly emphasized the exceeding smallness of the brain, expressing the supposition that many nervous fibres leading to the muscles had their origin, not in the brain, but in the spinal cord. This he maintained, partly because the sum of the transverse sections of all nerves leading to the muscles was far larger than the transverse sec* tion of the spinal cord at the bottom of the fourth ventricle, and partly because the cervical and the lumbar enlargements were to be found in vertebrates with four extremities, while no such formations were to be found in vertebrates without extremities. In the same Treatise Steno also touched upon other interesting questions concerning the brain ; but it would take too long to dwell upon them here. In his last work upon the brain, treating of a hydrocephalic calf, which he dissected in Innsbruck in 1669, Steno mentioned a number of observations on the structure of the brain; he also discussed the origin of the large quantity of fluid, and stated that he was of the opinion that the four ventricles were, in reality, only one single cavity. Finally he called attention to the fact that, though in this case the brain was exceedingly disfigured, both sensation and motion were normal. In the description of his dissection of a ray Steno explicitly dwelt on TheRepro= the peculiar eggsshells of this animal, which were in those days gene* ductiveOr= rally looked upon as being the uterus of the animal. Steno pointed S*nlra^ ■. out how this interpretation was in any case quite untenable; on the tion 0ft\^e whole he was not sure that these formations were really produced by Fetus. rays; but if they owed their origin to these animals, they could not be their uterus, but must be part of their eggs. At Steno's time natural philosophers were very uncertain as to how the fetus was nourished in the uterus and in the egg. Some thought that it received its food through the mouth, others that it received it through the bloodvessels of the umbilical cord. Steno's explanation of this process in placental animals was, as mentioned above, that the fetus was nourished through the placenta by a secretion of the villi, which he looked upon as glands. But once, when dissecting a newlyshatched chicken, he found the vitelline duct and became aware of its conveying the substance of the yolk direct into the intestine. As he had no idea of the existence of such a formation, still less of its function, his sur* prise was nearly overwhelming. He published this important discovery as his own; but it appears from a passage in a later Treatise that he was reproached with having done this, because, as his detractors main* tained, the discovery had already been made by others. Concerning the curious circumstances of this discovery, further particulars will be found in the notes (vol. I p. 263 of the present Edition). In the description of his dissection of a shark Steno, after having XXII LIFE AND WORKS OF NICOLAUS STENO mentioned the reproductive organs, set forth as his opinion, that the organs of the female mammals, in his days invariable named testes, were not to be regarded as organs corresponding to the testes of the male mammals; that they were, in fact, the same organs as the ovaries of the oviparous animals; that they produced eggs and conse* quently ought to be called ovaries. This was quite a new aspect of these organs. Steno does not go into details about this discovery, but he adds that he hopes to be able to take up the matter for further treatment at a later period. His thoughts, however, became occupied with many other matters, and he never wrote the intended large work. The fact of his having collected materials for it appears from two small Treatises in Acta Hafniensia. The investigations, upon which these Treatises are based, were, no doubt, made in close connection with the work just mentioned, but they were not published till 1675, in which interval — in 1672, five years after Steno's first communication — de Graaf had published his famous observations, and so he, quite justly, obtained the credit of the discovery of the true nature of the mammalian ovaries. As Gosch points out, it is well worth mentioning that de Gvaaf's view was so long in being universally accepted, be* cause it was observed that those formations in the ovaries, which were supposed to be eggs, did not loosen nor were carried away as such, which difficulty would probably have been of less importance, in case it had fallen to Steno's lot to promulgate the discovery, for al* ready in his first brief communication he expressed himself as follows : Non amplius dubito, qvin mulierum testes ovario analogi sint, qvocunqve demum modo ex testibus in uterum sive ipsa ova, sive ovis contenta materia transmittatur &c. The two Treatises of Steno's, which have just been mentioned, con;: tain much of considerable interest. Suffice it here to call attention to the series of observations on the development of the plagiostomes, which is found in the second Treatise. Already Aristotle relates, how in the shark Galeus Ixvis the egg is not only fully developed in the uterus, so that the fish becomes viviparous, but is also fastened to the uterus in a similar way as in the mammals, so that the fetus has both an umbilical cord and a placenta. As far as is known, no one had made this observation between Aristotle and Steno, who, however, in his communication says nothing of his being acquainted with this passage in Aristotle. After having given a more detailed description of other anatomical features of this shark (Galeus Ixvis) Steno proceeded to mention another shark (Acanthias vulgaris), also viviparous, also in pos* session of a yolk*sac and vitelline duct, but without a placenta. — Sub* sequent investigators found no shark with a placenta, until Johannes Miiller succeeded in finding once more what Aristotle and Steno had ob* served. This scientist pointed out that the reason, why others had not LIFE AND WORKS OF NICOLAUS STENO XXIII been able to discover what both Aristotle and Steno had found, was that there is another species of shark, common in the Mediterranean (Mustelus vulgaris) and closely related to the Galeus Ixvis, with which it is easily confounded, and this shark, though viviparous, has no placenta. Finally there is a little Treatise by Steno founded on the investiga* tion of a hare, in the one cornu uteri of which was found a fetus sartly resorbed, but to the astonishment of Steno not putrefied. Hence le concluded that women may hope that dead fetus, which are not Dorn in the natural way, may be resorbed without any putrefaction taking place. The fetus underlying this observation was probably a mummified one. Steno published a number of minor scattered observations and re* marks on anatomical and physiological subjects, among others on the image of the sun in the eye ; on the effect of snuff on the eye ; on the ve« sicles.which Malpighi found in the lungs ; on the liver of over*nourished animals; on the muscular fibres of the membranes surrounding the lungs (of a swan), which he thought were of use in the respiration, cxc. &c. It would carry us too far to enter upon these and other questions, as well as on Steno s descriptions of the particular dissections of various animals. An exception will only be made, as far as his publications on certain fishes (sharks and rays) are concerned, partly because they are most interesting in themselves, and partly because they form the connecting link between Steno's works on anatomy and physiology on one side and his works on geology on the other. The first fishes, of which Steno gave a description, were two rays. Having mentioned the system of the mucous canals, also a discovery of his, he went on to describe the position of the viscera, the glands of the stomach and the intestines, and the spiral lamina of the latter, which he also was the first to describe, fully realizing its importance to the digestion, in that it makes up for the greater length of the intestines in other animals. As has already been mentioned, he also touched upon the question of the egg-shells of the rays. Furthermore he de* scribed the structure of the branchiae, pointing out that the latter were constructed in such a manner that the water could only pass one way, the result being a constant supply of fresh water to the fish. He was of the opinion that the fishes were breathing in this manner, but said that the term respiratio might not be the correct one, when the matter in question was water; according to his belief the water in itself played the same part in the respiration of the fishes, as did the air in the respiration of the animals provided with lungs. It must be borne in mind that Steno wrote before Boyle and a hundred years before the discovery of the oxygen. After having meditated on the connection between the process of respiration in fishes and their lack of voice he proceeded to describe the operculum pupillare, by which Various Mi= nor Anato- mical and Physiologic cal Observa- tions. Rays and Sharks. XXIV LIFE AND WORKS OF NICOLAUS STENO he was led into a discussion of the morphology of fishes and mam* mals. A few years after his description of the anatomy of the ray Steno published an account of some discoveries, which he had made while dissecting the head of a big shark. Again he first dwelt on the system of the mucous canals ; then he described the lateral line system of canals, which he had discovered in the eel and refound in all the fishes he had afterwards examined; but as to the purpose of these canals he de* clared himself to be ignorant. He next mentioned the organs of secre* tion in the skin of the fish and the structure of the skin in general, and here his generalizations, for once, carried him beyond the actual facts. The structure of the eye was also touched upon by Steno, and he was the first to correctly describe the stem which in the plagio* stomes fixes the eye*ball in the orbit, as well as the optic nerve which earlier zoographers had failed to detect. At the same time he demonstrated the existence of a chiasma, which is lacking in other fishes, and called attention to various facts concerning the central nervous system, among others, as has already been mentioned, to the small size of the brain. In connection with this Treatise Steno published a brief description of another smaller shark (see above). He first men* tioned, how through this dissection he found the proofs of the cor* rectness of some of his earlier observations; he described the olfactory organ, where his attention had especially been attracted by the exi* stence of numerous folds of the skin, which he rightly regarded as being of the same importance to the function as the folded and spon* geous structure of the osseous tissue of the higher vertebrates. In the same place Steno furthermore maintained that the testes of the female mammals correspond to the ovaries of the oviparous animals; but this has already been mentioned in a previous section. One part of Steno s description of the head of a big shark is, how* ever, well worth dwelling upon, viz. the one which deals with the shark's teeth. Steno gave figures of the shark's head with its mouth open, as well as of single teeth, the figures being borrowed from the MS. of Mercati's as yet unpublished work Metallotheca Vati= cana; he described, how the several rows of teeth differed in con* sistence, and admitted that he was unable to understand the use of those teeth, which are quite soft and lie beneath the mucous mem* brane. But as early as in the following Treatise he set forth as his supposition that these soft teeth were meant to succeed the hard teeth, according as the latter were falling out, and in his work De Solido In= tta Solidum dxc. he finally arrived at a clear conception of their impor* tance. He also made comparisons between sharks' teeth and the bodies, Geology, which at his time were called glossopetrx. As to the formation of the latter the then current views were very much at variance; but the LIFE AND WORKS OF NICOLAUS STENO XXV theories, which were most generally accepted, tended towards the ex* planation that, like so many other bodies which were found in the earth and exactly resembled parts of animals or plants, they had been formed in the earth, at the place where they were found, either by a force inherent in the earth (vis plastica), by a lusus Naturx, or by the Creator himself; and as to the immanent forces of these bodies the curs rent opinions were alike unscientific. Contrary to most of the natu? ralists of those days Fabio Colonna had declared glossopetrx to be simply sharks' teeth in a fossil state. This also was Steno's opinion, and per? ceiving how close was the resemblance between sharks' teeth and the glossopetrx, and furthermore taking into account the nature of the soil in those parts where glossopetrx were round, he was, through the fol* lowing considerations, led to nothing less than the foundation of scientific geology; for he rightly perceived that what was true in the case of sharks' teeth, was necessarily also true in the case of all other parts of animals or plants found in the earth, and the six conjecturx he laid down consequently comprised all such bodies: 1. Terra, imde animalium partibus similia corpora eruuntur, corpora ilia hodie non pro= ducere videtur. 2. Eadem terra non videtur fuisse compacta, cum prxdicta corpora ibi producta sunt. 3. Nee forte repugnat, qvo minus eandem terram aqvis olim tectam fuisse credamus. 4. Nihil qvoqve obstare videtur qvo minus credamus, eandem terram aqvx olim fuisse immixtam. 5. Nee qvicqvam obstare video, qvo minus eandem terram pro aqvx sedimento sensim congesto habeamus. 6. Nihil obstare videtur, qvo minus anima= Hum partibus similia corpora, qvx e fern's eruuntur, pro animalium parti= bus habeantur. Steno gave good reasons for these conjectures; but as to his proofs reference must be made to the work itself. One point, however, is still to be mentioned, that in his list of contents Steno says that in earth from Malta are found vertebrae of fishes, closely resembling a vertebra still sticking in the clay, which Fr. Maria Fio= rentini had shown to him, a circumstance which certainly strengthened his opinion concerning the nature of the glossopetrx. Finally Steno touched upon the question of the way in which mineral substances come to fill up the spaces formerly occupied by organic bodies, having cast themselves entirely in the mould of the latter. As mentioned above the large, geological work, which Steno in? tended to write, was never accomplished, and only a Prodromus is extant. Because of the brief and condensed form of this work, so abounding with new ideas, it is impossible to give an account of it in a still more condensed form. Here again the reader must be referred to the book itself, though a few remarks on the state of geology at the time of Steno might perhaps be appropriate in this connection. It was universally taken for granted that the Earth had come into exi* stence only a few thousand years ago, created in the way which has XXVI LIFE AND WORKS OF NICOLAUS STENO been recorded in the Genesis. It was further presumed that the sur* face of the Earth, together with its animal and vegetable life, had un* dergone no essential changes, apart from those which had been occa* sioned by the Deluge and the inundations and volcanic eruptions mentioned by the historical writers. As to the difference between the various strata of the Earth the knowledge of those days was very im* perfect, and as to the origin of the several strata it was practically nil. The fossils occurring at certain places were, as has just been mentioned, looked upon as having been formed on the spot by means of an imma* nent force, or produced by the Creator himself. Whichever the view taken, there was no difficulty in accounting for the occurrence ot bo* dies, which e. g. resembled sharks' teeth or other parts of animals living in the sea, at places far from the sea, nay, even on mountains. If, on the contrary, these bodies were looked upon from the point of view of having really once belonged to animals, which had their home in the sea, there arose the apparently invincible difficulty of explaining how they could have reached these places far from the sea, where they are found, often in great numbers. The contents ot Steno's work will, as has been mentioned above, not be reported in this place; only its main lines will be set forth, and these as briefly as possible. After a thorough observation of the bodies exactly resembling animals or parts of animals which are to be found in the earth, and after a minute examination of the qualities ot the soil, in which they are found, Steno arrived at the absolutely un« questionable result that these bodies are remains of animals, and that these very bodies, if in every respect resembling animals living in the sea, must be the remains of such marine animals, and, finally, that they, together with the earth in which they are imbedded, must be sedimentary deposits. Steno finds that while certain strata of the Earth contain such bodies — fossils — there are others which never cons tain them, and the latter he rightly looked upon as the oldest, those which have formed the original Earth, on the surface of which the fossiliferous layers have been deposited as sediments of the sea. He further shows that each of the fossiliferous layers originally had an upper and a lower horizontal and level boundary plane, naturally produced by the way in which it has been formed. An exception from this rule is only the oldest and deepest fossiliferous layer, the upper surface of which, it is true, is horizontal and level, while the lower one has the form which corresponds with the surface of the non*fossilife* rous layer beneath it. Steno furthermore points out that at those rather numerous places, where the fossiliferous layers are limited by planes, which are not horizontal, the limiting planes are still level and parallel to one another, tor which reason their situation, deviating as it is from the original horizontality, must be looked upon as secondary, either LIFE AND WORKS OF NICOLAUS STENO XXVII produced by the collapsing of deeper layers — e. g. through the in* fluence of water and fire — beneath the upper layers, which then have shared in the collapse; or by the raising of deeper layers — e. g. by volcanic eruptions — which at the same time have raised the layers above them. Thus he also accounts for the occurrence of layers cons taining marine animals far above the present surface of the sea. — As the basis of his theory Steno had only the observations, which he had had the opportunity of making in Tuscany when travelling about the coun* try in the company of the Grand*Duke, and although Tuscany is especially favourable for observations of this sort, we can not but admire him for having found the time to make such a number of excellent observations as he did, but also more especially for the way in which, from out of his knowledge of such a very small part of the entire surface of the Earth, he was able to make generalizations applicable to the whole of the globe. Steno's explanation of the formation and the oc* currence of the fossils, as well as ot the nature and position of the va* rious strata, is the one still in force in our own days ; for after having fallen into oblivion for more than a century its position was established in the beginning of the nineteenth century, especially through Elie de Beaumont, who translated great parts of Steno's book, thus showing how tar he had reached, even at such an early date. There are two points, however, in the history of the formation of the Earth, in which Steno's knowledge is decidedly behind that of our time. Firstly, with regard to the changes which in the process of time have taken place in the surface of the Earth, where — for external as well as for internal reasons— he had to keep within that limited space of some few thousand years, which according to the doctrine of the Church had elapsed since the creation of the world, for which reason he had to prove, what appears to have given him some trouble, that all the changes in the surface of the Earth can have taken place during that short space of time. Secondly, he had to let all changes be occasioned by violent re* volutions in nature, partly to bring them within such a limited space of time, partly because, with the knowledge of those days, he could have no idea of the changes slowly and daily taking place in the sur* face of the Earth, and of the immense effects of these changes through exceedingly long periods. Steno's examination of bodies found in the earth was, as the very title of his book suggests, not limited to the remains of animal and vegetable life, that is fossils, but comprised all solid bodies, which in nature occur inclosed within other solid bodies, and thus he was also led to the study of crystals. Even scientists who had especially devoted their time to the investigation of crystals and their occurrence, as for in* stance Steno's friend Montanari, were of opinion that crystals still were being formed in the cavities of rocks, having a vegetative growth, and XXVIII LIFE AND WORKS OF NICOLAUS STENO drawing nourishment on that side where they stick to their matrix; it was likewise a current belief that if crystals were removed from the spot, where they were fixed, others would form themselves at the same spot. The explanation which Steno offered of the formation of the crystals was quite different from the latter theory; being based upon ingenious observations and conclusions it is once more the explanas tion, which holds good to this very day. Steno admitted that he was quite unable to determine the manner of the first delineation of cry? stals, but he maintained that crystals only increase in size in fluids and that the growth, when once begun, will continue through the me* dium of new crystalline matter, materia crystallina, being put to the planes of already delineated crystals. Steno, however, did not rest satisfied with this. After a thorough examination of different crystals — crystals of quartz, iron ore, pyrites and others — he showed that every crystallizable substance crystallizes in its own particular form, of which crystal forms he gave very exact descriptions with illustra* tions, being likewise the first to mention that the opposite planes of crystals are always parallel to one another. Steno also made numerous other valuable remarks and observations concerning crystals, which it would take too long to enumerate in this place. Not only did Steno's principal work on geology never appear; but even of smaller writings on geological subjects only two short Letters to Cosimo III are extant, containing descriptions of the grottos at Gresta and Moncodine, which were, in fact, not published till long after Steno's death. They are interesting, in that Steno here points out that rock«crystal can not be indurated ice, at that time a not un* common belief; but they are also remarkable because of the natural explanation which Steno gives of the fact that the temperature inside a grotto is so much lower than the temperature outside in summer time and vice versa in winter time, thus rendering the doctrine of the antiperistasis superfluous. Steno's work in the service of science did not end abruptly ; yet within a few years it rapidly diminished in quantity as well as in merit, until at last it ceased altogether, when he was only thirty*five years of age. HE present Edition o/ Steno comprises all the works of a scientific nature, which are known to exist from his hands. It embraces not only the scientific works, which he himself published (II. IV. V. VI. XIII. XV. XVI. XVII. XXII. XXIII. XXIV. XXVII) and those which he left to others to publish (X. XII. XIX. XX. XXI. XXV. XXVI. XXVIII. XXXI. XXXII. XXXIII), but also those which appeared without his knowledge, such as the Letters to Thomas Bartholin and Cosimo III and his Lecture on the anatomy of the brain (I. HI. VII. VIII. IX. XI. XIV. XVIII. XXIX. XXX). An Appendix has been added, com* prising two fragments of Letters (XXXIV. XXXV) dealing with observa= tions made by Steno, as well as the notes which his pupil, Holger Jaco* baeus, wrote on the dissections and lectures of Steno during the years of 1672-1674 (XXXVI). In the present Edition the works of Steno are printed in the order in which the researches, forming the basis of the various Treatises, were made. This is, according to the view of the editor, all the more justifiable, as in that manner it becomes possible to follow with ease the course of Steno's researches, while if the Treatises were arranged after their dates ofpubli= cation, works, which were very near to one another in subject and the dates of the researches they record, would have to be placed far apart. An arrangement of the Treatises after their contents would be quite im- possible to carry through, seeing that so many of the Treatises each of them deal with such widely different subjects. Below the halfititle of each Treatise have been placed the arms of the town where the researches, which are mentioned in the Treatise, wholly or for the greater part were made, or where the Treatise was composed. XXX The figures on the title=pages represent the Theatrum Anatomicum of Copenhagen at Steno's time. They are reproduced from Thomae Bar* tholini Cista Medica Hafhiensis. Hafhix 1662. In cases where the Treatise has been edited more than once, the editor has made use of the text of the original edition. Differences between the text of the original and that of the later editions have been mentioned in the notes, except in cases where they are of no interest whatsoever. Only in Treatise II the text of the second, considerably enlarged, edition has been preferred, which edition appeared as early as one year after the publi= cation of the first edition and was undertaken by Steno himself. Here, too, the notes call attention to all variations of interest between the two editions. By far the greater part of Steno's works are written in Latin. In all of these a uniform orthography has been carried through, corresponding as nearly as possible to the orthography of the first works o/Steno, published in Holland in 1 661—62, with the one exception, however, that the extensive, but inconsequent use of accents has been abandoned. Unquestionable mis= prints have simply been corrected, while in cases, where there is any un= certainty whatsoever as to the justice of the corrections made, the original reading has been given in the notes. This also applies to the Treatises which are written in French, Italian and English, but in the latter only mere misprints have been corrected, the orthography being otherwise exactly reproduced. In quotations from other writers Steno makes use of his own orthography; where there is any important difference between the quotations, as found in Steno, and the same passage in the writer quoted, these differences have been mentioned in the notes, whenever the works in question have been within the reach of the editor. In the extracts from the MS. o/Jacobaeus the same orthography has been carried through as in the text of Steno. Here as well as everywhere in the text of Steno the abbreviations have been expanded, partly to make the understanding easier, partly for typo= graphical reasons. The figures have been executed from photographs after the figures of the original editions, except a few of the figures in Treatise XXII, which unhappily have been reproduced by tracing the figures. The great plate in vol. II facing p. 238 and the figures in the MS. of Jacobaeus have been executed from photographs of the original drawings. With a very few exceptions, of which account has been rendered in the notes, they have all been reproduced in the size of the original. XXXI The object of the notes is : 1. To give concise information as to the facts mentioned by Steno, in cases where these facts cannot be supposed to be immediately intelligible to readers with an ordinary scientific training. 2. To give an account of the different, more important readings in the various editions o/Steno's works. 3. To give the correct and complete titles of the works, to which reference has been made by Steno, as well as to show where in these works the quotation or the passage referred to by Steno is to be found. 4. To give short biographical data about the persons mentioned by Ste* no. In the case of the Danes these data have been made a little more complete, as the foreign reader will have greater difficulty in procuring satisfactory information about them. Reference has generally been made to biographical dictionaries, such as must be supposed to exist in every larger library, only in a few cases to monographs on the persons in question. On the other hand no attempt has been made to give, in the notes, longer historical explanations of the relation of science to the various scientific questions, which have been treated in Steno's works, seeing that this would carry us much too far and naturally belongs somewhere else. The quotations in the notes have been printed with the orthography of the work, from which they have been taken, so also the titles of books. Exceptions are such quotations and titles, as the editor only knows at second hand. For typographical reasons it has also been impossible to render several of the abbreviations. The most important biographies of Steno are: Domenico Maria Manni, Vita Del Letter atissimo Monsig. NiccoloSte* none Di Danimarca Vescovo Di 1 itopoli E VicarioApostolico. Firenze 1 775. Angelus Fabronius, Vitae Italorum Doctrina Excellentium, Qui Sae= culis XVII. Et XVIII. Floruerunt. Pisis 1778-1805. vol. III. 1779. J. Wichfeld, Erindringer Om Den Danske Videnskabsmand Niels Sten* sen — Nicolaus Steno. Historisk Tidsskrift, 3 Rxkke, 4 Bind. Kjeben* havn 1865. C. C. A. Gosch, Udsigt Over Danmarks Zoologiske Literatur, 2 Afi deling, 1 Hefte. Kjebenhavn 1872. Wilhelm Plenkers S. J., Der Dane Niels Stensen. Freiburg im Breisgau 1884. A. D. Jorgensen, Mis Stensen. Kebenhavn 1884. XXXII I REGRET that it will be quite impossible to me to enumerate each one of the many, who have kindly placed their time and knowledge at my disposal, whenever I asked them for help. I must here content myself by begging them, one and all, to accept my best thanks. There are, however, three men, to whom I am under special oblis gations for their valuable and indefatigable assistance: V. KUHR, M. A. for his competent and careful assistance as regards the philolo* gical part of the work; CARL S. PETERSEN, Librarian at the Royal Library of Copenhagen, for the never failing kindness with which he has let me profit by his extensive knowledge, and R. H. STAMM, M. S., Lecturer at the University of Copenhagen, for much valuable information, especially as regards zoological matters, for all of which I beg these three men to accept my most heartfelt thanks. VILHELM MAAR DE PRIMA DUCTUS SALIVALIS EXTERIORIS INVENTIONE 6, BILSIANIS EXPERIMENTIS THOMA: BARTHOLINO HAFNIAM UM tuum in me affectum confidero, Celeberrime Vir, meqve nihil tale promeritum intueor, non pof* fum, qvin fummam tuam humanitatem ea, qva par eft, veneratione profeqvar: Tot enim tui amoris fe manifeftant argumenta, ut vel hinc mihi pateat.Ve* teres optimo jure Prxceptores fancti voluijje Parentis e loco, diemqve, qvo in difcipulorum numerum a te adoptatus fum, na* tali merito cenfeam comparandum. Qyid enim aliud fibi vindicant humaniffimae tuae litteras, digna cujus omnibus cum magna gratia* rum actione refponderem membris, nifi fingula tanta effent, ut pe* culiarem fibi refponfionem flagitarent? Qyod cum mea infantia non permittat, fatius duco grata hasc mente recondere, qvam, verbis prole* tario more gratias agendo, leviora qvam pro rei dignitate proferre. Cum vero, ut ductus falivalis exterioris iconem edam, in eadem epiftola author mihi fis, non poflum, qvin &. invidiam, qvam haec mihi inventiuncula peperit, ex fimul, qvem ex hac invidia percepi fructum, paucis tibi exponam, non ut in muftaceo laureolam qvae* ram, fed ut invidiofum plagii crimen a me rejiciam."* Doleo nam* qve, earn mihi imponi neceffitatem, ut vel de re non ita magni ponderis multa fari, vel turpem ignominiae notam fubire cogar. Res qvidem ipfa rite ' ponderata id neqvaqvam meretur, maxime cum fimilis omnino ductus jam ante fuerit inventus, qvin ipfe, de qvo in praefens agitur, a Cajferio, licet mufculi nomine (qvod ex tuis in 4 DE PRIMA DUCTUS SALIVALIS EXTERIORIS [I] buccinatoris mufculi hiftoria didici Inftitutionibus) obfervatus: Cum tamen, qvod ejus gratia mihi intentatur, crimen filentium minime patiatur, tibi, ut Praeceptori difcipulus, totam rem enarrabo, tuoqve judicio, qvid inde decernendum, relinqvam. Saepius jam a Clarif* fimo Sylvio ex a Celeberr. Dno. van Home fecundo exhibitus pub* lico ductus ille fuerat, cum aliqvot inde hebdomadibus, qvam ob caufam nefcio, abalienatus a me Clariff. Gerard. Blajius tantum fuis tribueret affectibus, ut, licet ductus iftius inqvifitioni manum nun* qvam admoverit; licet, cum femitruncatum illi primo exhiberem, qvid effet, non valuerit fignificare; licet in fuis ad Eyjfonium litte* ris Frater ejus paucis, anteqvam haec mihi fignificarentur, diebus inventionem illius mihi tribuerit; licet ipfe tandem in ultimo de Medicina Generali fcripto, rei, qvam fe reperiffe ait, nee verum affig* net ortum, nee exitum verum: nihilo minus Clariff. Viris Sylvio & van Home per Fratrem, hinc praedicto in libro omnibus fibi illam deberi, fignificaret. Qyae ut manifeftiora evadant, veniam dabis, fi &. inventionis occafionem, dx qvid inde actum, paucis expofuero. Annus eft, cum ego, a Blajio hofpitio exceptus, obfervans in illo, cui tertia ab adventu meo hebdomade finem imponebat, collegio commodam fubjecta Anatomica habendi occafionem, follicitarem Clariff. Virum, liceret, qvae mihi comparaturus effem, propria manu diffecare. Qyod cum impetraffem, faventem adeo fenfi fortunam, ut in primo, qvod 7. April, mihi emptum in Mufeolo folus feca* bam, ovillo capite ductum, a nemine, qvod fciam, defcriptum, in* venirem. Detractis qvippe communibus velamentis fectionem cere* bri meditabar, cum torte vagantia per ora vafa prius examinanda judico. Eo itaqve fine venarum arteriarumqve vias immiffo ftylo explorans, apicem obfervo non ulterius intra tunicarum anguftias coactum ampla in cavitate liberius vagari, moxqve ferrum protru* dens ipfos fonare dentes audio. Miratus rei novitatem Hofpitem voco, lententiam ejus auditurus, qvi primo vim accufare, mox ad ludentem faepius Naturam confugere, tandemqve Whartonum ad par* tes vocare. Sed cum nee ibi qvicqvam offenderet, nee tractata negli* gentius vafa longiorem inqvifitionem admitterent: majori cum atten* tione haec alia vice examinare decrevi, qvod ex paucis inde diebus in canino capite, licet obfeurius, fucceffit. Cum itaqve ufum vafis argueret magna cum inferiori affinitas, eodem menfe Praeftantiffimo Dn. Jacobo Henrico Paulli, amico conjunctiffimo, me vafculum ali* [I] INVENTIONE & BILSIANIS EXPERIMENTS 5 qvod falivale inveniffe, fignificavi, adjuncta aliqvali ejufdem de* fcriptione. Sed qvandoqvidem fimile qvid jam turn inventum fci* rem, nee, an aliis idem fuerit obfervatum, divinare poffem, filui, donee data occafione Clariffimum Sylvium ea de re confulere lice* ret: Qyi his auditis in homine qvaerendum ilium judicavit, inven* tumqve Spectatoribus aliqvoties demonftravit. Habes hie, Clariffime Vir, inventionis hiftoriam: Sed ut certior ea de re lis, en argumenta ab ipfis mihi accufatoribus fubminiftrata. Junior Blajius, J. D. ex Advocatus, qvi ad Majum ufqve menfem eodem anno Amftelodami degebat, qvi aedes noftras qvotidie ad* ibat, qvi fectionibus, qvas a Fratre ejus adminiftratas vidi, omni* bus intererat: hie, cum illius vafis mentionem publice factam a Domino van Home audiviffet, mifit eo nomine ad Eyjfonium, Pro* fefforem Groningenfem Celeberrimum, litteras inventionem ejus mihi tribuendo. Qyis credet itaqve, Fratrem cum Fratre, dum Am* ftelodami viveret, qvotide loqventem, novitatis, fi qvis unqvam, avi* diffimum, rerum Anatomicarum peritum, a Fratre reperta ipfi non adferipturum? Unum ab ipfis fuppeditatum mihi telum vidifti; lice* ret etiam plura proferre, fi operae pretium videretur: Sed qvamvis in privatis litteris Blajius non rationibus fe tuendo, fed convitiis, meqve mendacem, iniqvum, malevolum, invidiam fermento inflatum, ck nefcio qvid non, appellando meritus fit, ut non modo, qvas pro me facerent, omnia proferrem, fed ex, qvibus me oneravit, in ipfum rejicerem; cum tamen, qvae in me conjecit, nunqvam probaturum fciam, qvae in ilium retorqvenda, plerifqve adeo nota fint, ut meo non indigeant praeconio; fi in tarn nobili loco, in tanta omnis ge* neris eruditorum corona ex qvidem iterato nomen meum ductui ifti a Clariff. Domino van Home non fuiffet additum; de jure meo lubens ceffiffem. Jam vero ne in confeientiam trahatur modeftia, de illata mi* hi injuria vel invitus conqveri cogor. Ut vero ad alia tandem deve* niam, unum adhuc, qvod validiffimum judico, addam. Ipfe Blajius in eo, qvem de Medicina Generali fcripfit, tractatu, fe nunqvam in ductum ilium inqvifiviffe, manifefto indicio prodit; nee enim veram illi originem, nee egreffum verum tribuit, qvin ipfi, unde fcaturi* gines habet, glandulae ufum adeo ignobilem adferibit, ut nifi me ilium ei exhibuiffe certus eflem, nunqvam illi vifum affirmarem. Patebit hoc magis in ilia, qvam fub manibus habeo, difputatione. Qvandoqvidem enim parotidum affectus ex alii vicinarum partium 6 DE PRIMA DUCTUS SALIVALIS EXTERIORIS 111 morbi, qvi ex hifce aliisqve a me obfervatis lucem aliqvam accipere videntur, accuratius examen reqvirant; non abs re fore credidi, fi interea exercitii gratia de glandulis qvibufdam capitis cum earun* dem, ut in vitulino reperiuntur, vafis difputationem adornarem. Hoc enim parum aeqvae illius accufationi debeo, qvod, cum vitulinum caput, in qvo fe vafculum hoc reperiffe ait, ad defcriptionis illius normara examinarem, non modo ne umbram qvidem illius in vi* tulo vifam illi manifefte obfervarem, fed ex nova qvaedam lym* phatica notarem. Parotidum namqve examen 6v cum maxillarium, inferiori collatio in trium glandularum natura qvidem a prioribus diffidentium, per vafa autem commercia cum iifdem exercentium, inqvifitionem deduxit: e qvibus falivales glandular duas, interior unam, alteram exterior, fibi affociarunt, tertia in collo fita, fupe* riore fui parte, qvae gibba eft, a duabus illis vafa accipiens, novum ab inferiori &. concava parte fatis confpicuum canalem deorfum mit* tit, qvem refectum a trunco caput ulterius profeqvi vetabat. Sed de his in dicta difputatione uberius, modo ex clarius interea licuerit in alio eadem notare, cum alio ductu, qvem in thorace vidi a thora* cico ex fitu 6\ contenti colore difcrepantem, de qvo nihil obfervavi praeter ductum fatis longum in finiftro thoracis latere ultra noni nervorum paris interiorem ramum fitum, adqve glandulas jugulares adfeendentem, qvem, fi a fonte ad oftium ufqve accuratius profeqvi dabitur, una cum caeteris tibi, ut qvi primus haec vafa detexifti, c\ cui, qvos inde rivulos alii addidere, omnes debentur, in grati animi fignum, cum aliter gratum me oftendere non liceat, offeram. Cum autem vafis illius meminerim, afferam experimentum, qvod praedicta in alio cane fruftra qvaerenti fe praeter opinionem exhi* bens a Biljii partibus prima fronte magis effe apparuit, qvam re* vera fuit. Dum enim paftum nuper canem a coena illico aperio, primo ftatim adfpectu egregium praefentibus fpectaculum exhibuere albis lacteorum gyris undiqve picta inteftina, ut fangvini ad ilia delato recurrens inde lac copia cedere vix putarem. Sed qvia re* ceptaculum nondum lacte tinctum, ex thoracicus valde exilis, vin* culo huic injecto in craftinum canem repono. Seqventi die, qvaefitis fruftra caeteris, ad cifternam rediens omnia mutata reperio ; ipfa enim pridie arcta, ex nihil minus qvam lac referens, albo humore jam dif* tenta tumebat. Thoracicus etiam, vix turn confpicuus, fimili modo turgens plurimos oftendebat ramulos poft brevem digrefTum in eun* [I] INVENTIONE & BILSIANIS EXPERIMENTS 7 dem, unde orti, truncum redeuntes, qvod vero hue praecipue facit, a receptaculo ad glandulam ingvinalem ufqve productum vas to* turn lacte plenum confpiciebatur, licet qvidam e rivulis ad idem vas aliunde tendentibus lympham colore aqveo proderent. Mirabar ini* tio, qva ratione in glandulam derivatum lac valvularum repagulo non fuerit retentum, fed mox concidentes interdum in mortuo val* vulas refiftendo non effe facile videbam, maxime fi compreffo fe* mel vafe lateri, qvod a Clariff. Sylvio audivi, applicentur. Nee du* bito, qvin haec Biljium fallant, qvi, ut fuccum exprimat, vafa com* primit, unde admotae lateribus valvulae commeanti ultro citroqve liqvori facilem tranfitum condunt. Caetera iftius viri myfteria qvod attinet, minoris fenfim fieri videntur, cum &. Balfamo condita a Ce* leberr. Dn. van Home manus mumiis illius palmam dubiam faciat, c\ fectio fine fangvine non adeo difficulter poffet adminiftrari. Cum enim, ligaturis fe uti, nobis retulerit, facile apparet, qva ratione ex una parte corporis in alteram derivari poffit fangvis vivente adhuc animali. Ligato qvippe in vicinia cordis aortae trunco defcendente cum adfeendente cava, non dubito, qvin cor omnem ex inferiori corporis regione fangvinem exhauriens fuperiorem fit repleturum, eoqve modo facile foret vacuatas fangvine partes pro lubitu fe* care, &. viciffim, qvae vifum alias fugiunt, vafa humore turgentia oculis fubjicere videnda. Tentaffem haec, fi in vivorum fectione ma* gis fuiffem verfatus, nee angufta domi res ab illis me experimen* tis, qvae ex fumptus reqvirunt c\ tempus, retraxiffent. Magnam ni* hilominus fpem injecere mihi noviffimae tuae litterae, qvibus &. ad ftudia haec me animare voluifti, teqve mei memorem data occa* fione futurum affeverare. Maecenates namqve illi non defuturos fcio, cui fuam ea in re operam tantus vir pollicetur. Sed nimium te detineo. Vale, Clariffime Vir, meqve tuo favore dignari perge. Dab. Lugd. Batav. Ao. 1661. 22. Ap. T. Obfeqv. NICOLAUS STENONIS DE GLANDULIS ORIS & NOVIS INDE PRODEUNTIBUS SALIVA VASIS PERILLUSTRI & GENEROSISSIMO HEROI, D.OTHONI KRAGIO, Dno. de Wolberrig, Senatori Regio Ampliffimo, & ad Celfiff. Belgii Foederati Ordines Exlegato Graviffimo, arcis & territorii Neoburgenfis in Fionia Gubernatori, ADMODUM VENERABILI & VIGILANTISSIMO PATRI. D.D.JOHANNI JOH. SVANINGIO, Daniae ex Norwegian Archiepifcopo Confummatiffimo, in Collegio Status Affeffori & Gollegii Confiftorialis Praefidi, CLARISSIMO & EXPERIENTISSIMO VIRO, D. D. THOMiE BARTHOLINO, Ser. Reg. Maj. Dan. & Norw. in Acad. Hafhienfi Profeffori Honorario Celeberrimo, &. Facult. Med. Decano, Maecenatibus, Promotoribus, Praeceptori obfeqvio aeternum devinctus Humiliter 6- officiofe NICOLAUS STENONIS D. D. D. i NTER alia, qvx caufx ignoratio mirandis accenfet, fum* mam meretur admirationem ilia menti humanx divinitus ) concejfa vis, qva recepta per fenfus rerum Jimulachra, Iqvandocunqve placuerit, Jibi reprxfentat, & res abfentes • qvafi prxfentes, omnesqve, qvas in ipjis ante obfervavit, \ partes in imagine intuetur eadem figura, magnitudine, colore, Jitu, melius longe ac Ji a Protogene, cujus etiam rudimenta cum naturx veritate certabant, ad vivum fuiffent delineatx. Adeamus enim, qvi rerum naturalium rationes fcrutandi avidus inter experimenta xta* tern confumpfit, fenem, fed viridi fenecta gaudentem, eumqve intra tarn parvx capacitatis fphxram, cranium intra, immenfum & per fpa= tia fere infinita extenfum univerfum univerfiqve membra animo per* currere mirabimur. Hie ad afha evolans conftantem fixorum ordinem, fallere nefcios planetarum errores, omni lege carentes cometarum ex* curfus nobis evolvet; inde momento relapfus aerem pervagabitur, &■ jucundas colorum varietates, ftupendas ignium formas in illis regionibus fe per intervalla oftendentes depinget; hinc in terram defcendens, varia, qvx fe ibi offerunt, accuratiffime elaborata Naturx opera, & illis vix cedentia artis imitamina exponet: tandem in terrx vifcera penetrabit, & abdita mineralium myfleria revelabit. Has ille ideas omnes nutui fuo habet obfeqventes, ac Ji macrocofmus microcofmo lateret inclufus. Sed ut ilia facilis adeo receptarum imaginum omnium conjideratio miraculo plena eft; ita fingularum receptio, ft rem integre reprxfentabunt, magno cum labore & difficultate conjuncta, &■ vix unqvam ab ullo fperanda. Mens enim in varietate delectationem qvxrens adeo in potentia fua im= potens eft; ut, dum in rerum examine verfatur, to hoc age fxbi non poffit imperare, nee ab aliis cogitationibus adeo vacuam fe reddere, ut uni foli vacet conftanter: partium autem, e qvibus naturalia corpora com* 14 [III ponuntuv, juncta multitudini fubtilitas tanta eft, ut vel maxime attention fallat &■ eludat. Qvid mivamur itaqve, licet ab omni xvo multi fummo labove £>. ftudio indefeffo id egerint, ut animalium fabricx ideam omnU bus numeris redderent abfolutam, eandem nihilominus etiamnum muti= lam deprehendi &■ imperfectam? Qyod ft enim, qvi exteviora duntaxat integri animalis lineamenta penicillo imitantur, nunqvam circumfpecte adeo omnia obfervant, qvin ejufdem artis peritior accedens alius alia inve= niat delenda, fupplenda alia, alia mutanda, qvid ab illis, qvi prxter ex= teriorum partium inter fe proportionem etiam inteviovum omnium ima= gines cerebro infcvibeve nituntuv, majorem exfpectamus perfectionem? Artiftciofa ftngularum textura, Dxdalea junctarum coagmentatio tot in* volvuntur admirandis, tarn ubevem qvxrendorum fegetem oftendunt, ut, licet multorum in unum confpiret labor, licet longa annorum fevies acce* dat, vix tamen certam eaxum cognitionem exfpectare liceat. Sunt, fa= teov, qvi ad illam, de qva loqvimur, ideam perficiendam faciliorem pateve viam fibi perfvadent, nee opus, ut externis omnia fenftbus fubjiciantur, poffe folam rationem, qvx defiderantuv, cxtexa fuppleve. Sed eodem &■ ego jure exiftimavem, ut heroicam Alexandri Magni gxavitatem mutx Apelles imagini davet, fuffecijje tumultuaviam fpirantis faciei infpec= tionem, potuijfe eum, qvx eadem velocitate affeqvi non valuit, ex in* genio fufftcere. Veveov autem, ne illorum cenfuvam mererer, qvi dice rent, heroicam qvidem majeftatem eo modo exprimi, non autem maj- eftatem Alexandri. Sic 6- pvxfenti in negotio, qvamvis ingenii in novas ex ante obfewatavum conjunctione 6- fepavatione ftguras gignendo magna vis Jit, qvamvis nihil illi facilius, qvam varias ejufdem rei caufas com* minifci, ubi tamen res ipfa filet, qvicqvid illud loqvitur, pojfe qvidem id ita effe, firmiffimis demon/hat argumentis, effe autem, affeverare non fuftinet. Id qvod latius diducerem, nift veftra, Magni Viri, in re mentis vires fpectante cognitio, qvantum humana fors patitur, perfecta ruborem mihi incuteret, ne dicam, ftlentium imperaret. Vos enim, &■ Veterum monumentis eruditi, &. longo rerum ufu docti, in ipfa hujus Dex adyta penetrajhs, adeoqve, qvid ad conceptus qvam integerrimos formandos reqviratur, penitius pervidetis. Suffecerit itaqve unum item & alterum duntaxat exemplum attulijfe, ex lymphaticorum hiftoria peti* turn. Qvis per tot fecula, etiam ab ingenio paratiffimus, vel per fom= nium de lymphaticis cogitavit, anteqvam tuis ea, Clariff. Bartholine, non mentis, fed corporis obfervata oculis, omnium oculis exponeres? Sed ab illo tempore, qvis folo ingenio, qvx etiamnum latent, valuit revelare? [II] 15 Quis in hepate vel in relievo corpore, unde lymphatkorum extrema oriantur, certo argumento demonjirare? Eandem obfervationum necef= jitatem falivx origo comprobat: qvam in os deponentes vias fenfuum ope defiituta ratio nullas invenit; nee, qvx materiam ejus glandulis advehunt, qvantum ego qvidem mente affeqvi valeo, certx unqvam nobis erunt, Ji a folo ingenio exfpectandx. Rationi accedat, oportet, obfer= vatio, 6- fecundum omnes, qvantum licet, partes res ipfa examinetur, ut rem vere exhibens menti inferibatur figura. Qyod dum pro virili qvifqve hoc feculo agit, fuasqve eo fine examinandas proponit obfer= vationes, non potui, qvin £. ego, qvx ad lymphatkorum non modo revehentium ufum, fatis alias confirmatum, illujirandum , fed 6- eve= hentium numerum augendum conferre obfervavi, publico proponerem, &■ magnis, qvos alii congejjere, acervis parvulum adder em manipulum. Ne autem fine patronis hie effet libellus, vobis, magna Patrix lumina, & vefiro eum nomini inferipfi, cum illud naturale divini ingenii vefiri lumen fvaderet, multiplici ufu acqvifita fagacitas fiagitaret, magna par= tim in me, partim in meos promerita juberent. Sereno itaqve vultu hxc qvaliacunqve fortunx laborum meotum initiis benignius adfpirantis munera excipite, &■ qvi felicem per plurima lufira vitx decurfum, &■ nunqvam morituram nominis gloriam vobis opto &- voveo, ulteriori fa= voris vefiri aura fovete. Lugd. Batav. Anno 1661. § 1. JVISQVIS cum convicto a Socrate Ariftodemo admife* rit, qvod omnes fana ratione utentes admittere tenen* tur, animalium fabricam CocpoO nvog brnnioupyou, xai tpiAo£coou re/vrjua effe, non inficiabitur, cum omnia illorum membra partesqve in membris con* tentae omnes TTpovOTyrixcbg' fe factas ipfae paene lo* qvantur, cum tarn minutum nihil videatur, qvod fuo non deftina* turn fit ufui, nihil tarn abjectum, qvod Conditoris fapientiam non doceat, demonftret, ut dexteritatem Apellis olim fimpliciffima artisqve ignaro ridenda linea. Si enim qvi ex mentis ex motus expertia fimula* chra fingunt, ne qvid deficiat, ne abundet aliqvid, ut omnia, etiam minima, qvam accuratiffime elaborata fubjiciantur oculis, ftudiofe conantur; fi architectus vitio fibi ducit in exftructo a fe aedificio vel tantillum fpatii otiofum, nee certo fcopo deferviens, relinqvere: qvis credet ab illo, qvem confummatiffimi qviqve artifices ad imitandum fibi, licet impari fucceffu, proponunt, inanem ulla in parte locatam operam, & fruftra qvicqvam productum? Qyis non potius, etiam in minimis maximum, imo admirandum latere artificium, judicabit? § 2. Proinde dolendum, fuiffe inter magni nominis viros, qvi non pauca tantum (5r||U£iou X^PIV m animalibus facta dicere fuftinue* rint, cum menti confilioqve divino nihil magis repugnet. Dolendum magis, effe, qvi de qvibufdam fummi terrarum Architecti operibus abjecte adeo fentiunt, ut, qvod exilia videantur, qvod magnum primo intuitu apparatum non oftentent, qvorum inqvifitioni tempus impen* datur, indigna judicent, imo verbis ipfa, paene contumeliofis, re* jiciant. Humanae qvidem infirmitatis eft, qvod, qvi fenfibus non utentes, fed abutentes, non nifi jucunda cv fplendida fectantur, £v xropepupej, JtfthpcOY venerantes, Silenos Alcibiadis tranfeant, di* 18 DE GLANDULIS ORIS & NOVIS INDE [II] ligentiffimi Naturae fcrutatores futuri, fi Epicuream in omnibus (ut Cicero loqvi amat) Pronoea fe noftra exhibuiffet. Qyod vero neg* lexifle, parum illis videatur, nifi etiam cenforia adhibeatur virgula in iis, qvae nulla ratione percipiuntur, non infirmitatis amplius, fed malitiae eft argumentum. Prudentior olim lingva magni illius Sa* pientis, qvi de libro qvodam fententiam rogatus: bona erant, qvae intellexi, inqvit, forfan & qvae non intellexi. § 3. Inter varias autem animalium partes, qvae iniqvitatem for* tunae paffae, primo loco veniunt glandulx, qvae, ut tcov (3e(3i\Xcov contemptum effugere faepe non potuerunt, fie neqve roi£ opyt'oiq ^7TicJTr](ar|c; TETeXeOjaevaDv cenfuram declinare, indicta caufa, ex ex* qvifitiori examine neglecto: cum tamen talium faepe morborum au* thores fuerint, ut, qvos fimplex &. inculta facies in fui examen non perduxerat, qvos fummum Conditoris artificium in aliis manifeftum in fimilem de his opinionem non pertraxerat, eos neceffitas eo compellere potuiffet, debuiffet. Docent hoc anginae, fcrofulae, paroti* des, bubones, caetera mala, qvae, ut fummo faepe periculo in vitalia noftra graffantur, ita mirandas humorum ex una in aliam partem derivationes non raro produnt: ut propterea inveftigatio earum, ex ad cognofcendum corpus totius orbis nobiliffimum pulcherrima fit, ex ad fanitatem obtinendam procurandamqve neceffaria. § 4. Qvae Veterum de illis fuerit cognitio, fi res ipfa infpiciatur, minuta valde ex exilis apparet. Cum enim qvaedam nonnullis glan* dulis cum fpongiis communia viderent, fubftitere in fimili hoc, dx fpongiarum munus illis attribuentes, defunctos fe munere fuo, ex rem totam detexiffe crediderunt. Humano qvippe ingenio familiare eft, ut, fi qvid in eo, qvod examinandum nobis proponimus, ob* jecto occurrerit fimili modo cum re ante percepta fenfus noftros afficiens, illud prius cognitum illico menti etiam invitae denuo re* praefentetur: unde fit, ut, rei magis perfpectae proprietates alteri tribuendo, ab ulteriori examine defiftamus. Sic vi attractiva Mag* netis obfervata, per Magnetifmum omnia explicare conati qvidam. Sic in homine focum fibi ex ollam imaginando alii, ne a fimili recederent, etiam cochlearia, fpatulas, opercula, coqvos invenere. Sic qvi antliis vafa lympham vehentia comparant, partes, exantlan* tium inftar, ex puteo (fie illi receptaculum chyli vocant) lympham attrahere fingunt. Nee alia ratione, cum raram in glandulis, ton* fillis praecipue, texturam viderent, fpongias dixere cum illis reli* [II] PRODEUNTIBUS SALIVJE VASIS 19 qvas. Si hifce fimilibus fepofitis rem ipfam audire defideres, per* pauca effe, qvae de illis cognita fuere Antiqvis, offendes. Nolim tamen haec ita dicta, ac fi Veteribus, qvorum authoritas mihi fern* per venerabilis, femper honorata, qvicqvam detractum earn, ut qvi haud dubie perfvafus fim, nihil fimul ex inventum & perfectum hactenus fuiffe. Lumen accenderunt illi; noftrum eft, ut accenfum confervetur, ex luculentius eundo inardefcat. § 5. Illud fimilitudinum velum, qvo glandularum cognitio diu obducta latuit, poftqvam viae qvaedam peculiares in illis detectae funt, fenfim coepit removed. Hinc enim patuit, eas nee fuperfluas humiditates, fpongiae ad exemplum, imbibere, nee publicam vifce* rum totiusqve corporis fentinam effe; fed ufui longe nobiliori di* catas. Cum itaqve dx mihi, his facris operanti, licuerit qvaedam (nee* dum, qvod fciam, a qvoqvam defcripta) in illis vafa notare, qvae non modo ad novam illarum dignitatem ftabiliendam facere, fed &. Medicae arti lucem non omnino nullam praebere, ex qvafdam naturae tantum cognitas ante vias etiam nobis notas reddere exifti* mem, non ab re fore putavi has qvalefcunqve obfervationes publico communicare, ut qvi otio ex manu plus valent, accuratius dx Reip. Medicae fructuofius in ilia inqvirant. § 6. Conftitueram nuper itaqve, Clariffimorum Praeceptorum D.D. Bartholini 6- Sylvii judicio obtemperaturus, ductus falivaris exterioris, vaforumqve in glandula oculi innominata obfervatorum, aliorumqve delineationem adornare, cum, Dominum Gerardum Leonardi Blajium, Hofpitem qvondam dx Praeceptorem dilectum, in fuo de Medicina Generali tractatu ductus iftius a me fibi jam ante demonftrati men* tionem facere obfervans, praeoccupatum mihi ex parte laborem ilium putarem. Credideram enim, ilium in ipfo opere, nova accurataqve, ut ait, methodo defcripta, rem, cujus fe inventorem in limine pro* fitetur, qvamqve praeter vix novi qvicqvam in libro illo contineri ipfe teftatur, accurata defcriptione perfecuturum, maxime cum non modo commoda fe ibi offerret occalio, fed fufcepta partium corporis delineatio id qvadam neceffitate poftulare videretur. § 7. Cum vero accuratius verba ejus examinarem, videremqve, eum ductui tarn brevi, tarn manifefto nee verum ortum, nee egreffum verum affignare potuiffe (ut patebit th. 15.). imo ipfam, e qva tarn eleganti copiofiffimorum rivulorum confluxu prodit, glandulam ufui adeo ignobili deftinaffe (ut th. 17. manifeftum), ut, nifi femel atqve iterum 20 DE GLANDULIS ORIS & NOVIS INDE [III me illi haec demonftraffe certus effera, nunqvam ab illo vifa crede* rem, in re adeo exigua tarn parum fibi conftare, magnopere mirabar. § 8. Multum tamen debeo Clariff. Viro, qvod occafionem dede* rit, non modo meum mihi vindicandi, fed ex nova qvaedam alia inveniendi. Dum enim feriis Pafchalibus hujus anni parotides dictas in vitulino, qvo ille provocavit, rimor, ex vafa, qvo me trahunt, feqvor: elegantem variarum in collo glandularum per peculiaria vafa confenfum non fine admiratione obfervo. Qyibus vifis, ut certior de illis fierem, fecundum vitulinum caput feco, hinc cv canes aperio, tandem qvoqve bubulum caput examino, ubi plura falivae vafa non exfpectanti fe obtulere. Ut itaqve Praeceptoribus morem geram, ex, qvibus magis commodum, alii accuratius ilia examinent, conftitui hac occafione obfervationum mearum qvalemcunqve delineationem dare, veniam, ficubi forte errare contigerit, a peritioribus mihi promittens. § 9. Qvae continuum ori humorem fuppeditant, glandulae non una? funt, nee uno in loco fitae. Nam praeter maxillares ex tonfil* las, a Clariff. Whartono defcriptas, alias obfervavi fub auribus, in buccarum regione, fub lingva, in palato: qvae omnes in eo con* veniunt, qvod ex plurimis glandulofae carnis qvafi fragmentis, imo glomis fibrarum, nervorum, vaforumqve, ex membranarum ope inter fe connexis fint compofitae, adeoqve ex earum genere, qvas conglomeratas Celeberrimus Vir Fvancifcus Sylvius appellat. Glandulx qvippe omnes proprie dictae, licet parenchymata fint fui generis non fangvinea, fed alba, pingvia, venis, nervis, arteriisqve, ex vafls Iym* phaticis praedita, varias tamen, variis fundamentis nitentes, admit* tunt differentias: qvas inter nulla rem propius attingit ea, qvam Vir Clariff. modo nominatus proponit. Ille enim non vafa, utpote qvae necdum in omnibus detecta, nee ulum, qvippe minus adhuc cognitum, led ipfam conformationem relpiciendo duo primaria ilia* rum genera, Difp. Med. 5 de Lienis &■ Glandul. Ufu th. 26. ex 27., de* fcribit: funt enim alix ex variis qvafi partibus 8- minoribus glandulis conglomerate, &■ cum aliqva fuperficiei fux inxqvalitate conglutinatis exfurgentes; alix vero xqvalem fuperficiem habentes, &■ ex una qvafi fibi continuata Jubftantia conflatx & conglobatx obfervantur: cui po* ftremo generi ex hoc peculiare eft, qvod altera parte convexum lym* phatica ut plurimum excipiat, altera vero concavum orta interius ex plurimis tenellis rivulis alia lymphatica ex fe emittat. Ut autem glandularum, lie ex lymphaticorum, ob contenti colorem Clar. Bar* [Ill PRODEUNTIBUS SALIVA! VASIS 21 tholino ita dictorum, duo genera reperiuntur. Qyae enim in conglo* batis vifuntur, omnia liqvorem fuum in venas reducunt, cum ilia, qvae e conglomerate prodeunt, contenta in cavitates notabiles, ut funt oculi, nares, os, inteftinum tenue, deponant. Licet autem ftomaticx glandulx (fie enim, qvae ori proxime in* ferviunt, omnes communi nomine poffunt infigniri) ejufdem gene* ris fint, fimiliaqve vafa poffideant, numero tamen vaforum diftin* gvuntur, qvaedam enim unico duntaxat excretorio vafe praedita funt, ut qvae fub auribus c\ fub maxillis reperiuntur, qvaedam pluribus, ut reliqvae qvatuor, qvae nempe in buccis, fub lingva cv in palato obfervantur, ut c\ tonfillae, cum vero tonfillas una cum maxillaribus inferioribus earumqve vafis Whartonus defcripferit, ea, qvae ab aliis defcripta nondum fcimus, propofuiffe contenti, actum agere nolumus. § 10. Sub auribus Jitx glandulx, ut bene fe habentes peculiare nihil ex a caeteris diftinctum Veteribus exhibuerunt, fie nee proprium fibi nomen apud eofdem invenere. Videtur qvidem Hippocr.Lib.de Gland. hac defcriptione illas indigitaffe: dbevec; be xarct roiv ouctroiv ev$a xai ev&a exarepco^ev xarct xaq depayac, xov rpaxr\\ou; fi vero facta hie loci glandularum enumeratio conferatur cum re* cenfione earundem brevi poft in eodem tractatu propofita, facile patet, defcriptionem hanc generalem effe omnibusqve jugularibus eo tempore cognitis communem, qvas paulo infra JTapiCf&jUia vocat, prout &. Zwingerus in tabulis exponit, ex ipfe author, verborum fuo* rum optimus interpres, manifefte declarat, dum fe Ttepi dbeVcov oi)Xo|LieXir|<; rpaxrjXou acturum ait. Qyas autem Parotidas dix* erunt Veteres, non ipfae glandulae fuere, fed fub auribus, vel poft eas, obfervati tumores, qvos alias tTidp^iaxa ex (prjpea nominarunt. Sic ret Ttapct ret (bxa, qvorum toties apud Hippocratem mentio, licet proprie cv per fe confiderata potius, qvae naturaliter ibi repe* riuntur, defignent; fi tamen ipfe divinus fenex confulatur, praeter* naturale qvid hac voce intelligendum vult. Hinc Epidem. I, feet. 3: old be ret 7rapct tct wra y^o^o- (ivo l°co' ut> ^^ caetera pro* ferre liceret, taceam, fatis manifeftum eft, morbofum qvid hoc no* mine venire, idem fcilicet, qvod Graecam vocem Latina civitate donando Parotida Celfus Pliniusqve appellarunt. Licet itaqve haec verbi vis apud illos fuerit, cum tamen ratione fui morbi fubjecto non minus qvam morbo conveniat, non incommode, ut commu* niter fit, ipfis glandulis poffet concedi, fi plures dx diverfi generis 22 DE GLANDULIS ORIS & NOVIS INDE [II] eodem in loco non reperirentur. Superiori enim anno jam prae* cipite, cum in Nofocomio praxin faciendo qvotidie doceret Cla* riff. Francifcus Sylvius, exhibuit turn difcipulis, turn qvibus intereffe libuit aliis, inter caetera, qvae data occafione aperiebat cadavera, fcro* fulis affectas in qvodam conglobatas omnes non in reliqvo modo corpore, fed dx circa aurium regionem, falivarium utraqve cum pans create integra exiftente. Ut itaqve diftincte confiderentur, poterit haec, de qva nobis fermo eft, parotis conglomerata appellari, nomine conglobatarum parotidum reliqvis relicto. § 11. Parotis conglomerata (ut in vitulo obfervatur) in fovea fub auricula, inter pofterius inferioris maxillae latus proceffumqve ma* ftoideo refpondentem confpicua, fuper offis hyoidis cornu fita eft, figura plane irregulari, utpote qvam circumfitarum partium afperi* tates dx eminentiae admittunt. Notandum tamen, inferiorem ejus partem in longum extenuatam effe, media craffiore exiftente: unde fuperiora verfus anterior pars in limbum expanfa, oblongam aliam ex conglobatam fere totam finu fuo abfcondit, qvem praeter finum variae pro vaforum, praecipue vero nervorum, qvi ex magni ex co* pioli per earn in alias partes diftribuuntur, tranfitu viae notantur. § 12. Magnitudinem pondere expreffit Dn. Whartonus, qvi facta hujus cum reliqvis comparatione obfervavit parotidem pendentem 5iiijff, maxillarem internam J>ijff. In fcetu autem vaccino hujus pondus Siij aeqvare, illius vero £ij deprehendit. Idem refert, fe in eqvo exfecuiffe unam, qvae pendebat 5xj, nee tamen praeter* naturalis erat, aut folito tumidior. Qvibus Clariff. Vir copiam ma* teriae expreffiffe videretur, extenfione non determinata, nifi jam ante conftare putaffet, materiam in utraqve eodem modo effe difpofitam, qvod ex innuit, dum fubftantiam utriqve fimilem adferibit. Ne ta* men hujus ad illam proportionem exacte obfervatam effe credam, fvadet, praeter nervos majores copiofioresqve per fuperiorem dela* tos, minor majori inclufa glandula, qvam, utpote a reliqva non dif* tinctam, pondus illius auxiffe puto. Nam in bubulo inveni paro* tidem dictam, a vafis ix fibi appofita conglobata liberatam, pen* dere Siiijfl, cum maxillaris inferior 5iiij tantum adaeqvaret. § 13. Vicinis partibus fibrarum vaforumqve dx praecipue nervo* rum ope annectitur. Nervi enim qvinti paris ramus durior, infig* nibus earn furculis variis in locis perforans, tarn fuperiora qvam inferiora verfus propagines mittit, qvae turn variis in locis, turn prae* [II] PRODEUNTIBUS SALIVJE VASIS 23 cipue glandulam inter dx reliqvum, cui apponitur ilia, caput, inter fe varie concurrentes, plexum qvendam formant. Qyos praeter alii, a ramo temporalem mufculum inter & maxillam antrorfum delato reflexi, ad vafis excretorii latus retrorfum in ipfam glandulam fe* runtur. Vafa, qvae ibi reperiuntur, trium generum funt. Nam prae* ter venas d\ arterias, a jugularium carotidumqve exteriorum externis ramis fubminiftratas, etiam peculiare vafculum obtinuit, qvod in ovillo capite fuperiori anno Amftelodami a me repertum. Cum enim, a D. Gerar. Leon. Blafio, Clar. Gymnafii Amftelodamenfis Profeffore, circa feftum Pafchatos hofpitio exceptus, in illo, cui fexta ab ad* ventu meo lectione finem imponebat, collegio commodam animalia exercitio Anatomico convenientia habendi occafionem animadver* terem, obtinui ab illo, liceret empta mihi fubjecta privatim diffe* care, ut, qvae a diverfis in arte Anatomica exercitatiffimis viris ob* fervaram hactenus, &. mente revolverem, dx manu imitarer. Jamqve eo nomine VII. Aprilis, qvod mihi comparaveram , ovillum caput folus in mufeolo adornabam, cerebrum diffecturus, cum in fui me examen decurrentes per ora venae dx. arteriae rapiunt: qvae dum ftylo varie fcrutor, fentio me, per vas aliqvod in amplam oris cavitatem delatum, ipfos dentes ferire. Miratus rei novitatem Hofpitem voco, fententiam ejus auditurus, qvi, cum primo vim, mox ludentem Naturam accufaffet, tandem Whavtonum accuratius examinandum judicabat. § 14. Oritur autem Vas illud falivare intra nominatam faepius pa* rotidem conglomeratam pluribus e rivulis in unum alveum con* fluentibus, qvi inde, in vitulino, ut dx in ovillo, verfus inferiora delatus, ab inferioris maxillae angulo ad finum lateri ejus imo in* fculptum tendit, unde obliqve antrorfum adfurgens tandem foramine fatis amplo, papillarum fummae dx poftremae ad molarium fecun* dum fitae infculpto, in partem oris exteriorem patet. Notandi in eo praeter propriam tunicam varii nervei funiculi, qvi, nil nifi plu* rima filamenta repraefentantes, utrinqve ad latera ejus feruntur, dx hinc inde per praedicta filamenta fibi mutuo innexi medium due* turn amplexantur. Non mirum itaqve, difficulter adeo per divifas tunicas in cavitatem ipfam intrudi ftylum, cum, inter nerveos funi* culos haerens, ab ulteriori progreffu impediatur. Si in homine rectum ejus tramitem, qvo glandulam inter dx buccinatoris medium fertur, confideramus, videtur idem effe cum robufto vinculo, qvod, e centro 24 DE GLANDULIS ORIS & NOVIS INDE [II] buccinatoris exterius enatum, os genarum perreptare, ex in mufculum qvendam parvum ex gracilem buccae directe oppofitum terminari, Cajferius fcribit. Plura de eo, ut in homine obfervatur, licet a prae* dictis non multum differant, cum fciam, Clariff. Prxjidem in fuis ad Vefalium commentariis id acturum, hie non addam. § 15. Videamus, qva ratione praedicta defcribat D. Blajius. Medi= tin. General, p. 63. haec leguntur: Saliva eft humor &c, ex few maxime conftans, caloris ope a mafta fangvinea in glandulis maxillaribus fe= gregato, £. hinc per ductum falivalem in maxilla fuperiori xqve ac inferiori notabilem ad glandulas oris anteriores delato, ut inde motu lingvx expreffus inferviat guftationi &c. Ergo terminus a qvo, glan* dulae maxillares, terminus ad qvem, glandulae oris anteriores; ut motum lingvae, qvi ad expreffionem parum facit, taceam. Glandu* las autem maxillares eodem libro p. 23. fie defcribit: Maxillares glandulae, tarn qvx externx, in media fere longitudine maxillx inferioris jitx, qvam qvx internx, a parotidibus ufqve ad mentum fefe varia magnitudinis colorisqve fpecie exhibentes, ductu Jingulari ab ufu fa- livalis dicto gaudentes &c. Cum vero ab internis internum ductum procedere Whartonus, &. port eum in prima de ductibus falivaribus difputatione Clariffimus Praefes Johannes van Home oftenderint, ab externis exterioris origo fecundum eum deducenda. Certe fi accu* ratius Whartoni verba, unde defcriptionem hanc defumpfit, exami* naffet, vidiffet facile, tanto ductui illas nulla proportione refpondere. Sic enim laudatus faepe Doctiffimus Vir cap. 21. eas delineat: Max= illares externx exigux admodum funt & minoris momenti; Jitx funt exterius in media fere longitudine maxillx inferioris. Sed qvid verbis opus, cum ipfa experientia loqvitur? Admoveat inqvifitioni manum, ex, qva veritate haec dixerit, facile inveniet: nee eft, qvod qvis exi* ftimet, eum maxillarium externarum numero falivares exteriores adferibere; ne enim hac ratione poffet excufari, ipfe feqventi capite egregie cavit, ubi eas a prioribus diftinctas parotidum nomine de* fcribit. Eadem fide terminum ad qvem proponit: vidit enim, qvo modo inferiores terminentur; hinc non erraturum fe credidit, fi ex* terioribus fimilem tribueret infertionem. Sed longe aliter fcripfiflet Clariffimus Vir, nee glandulas, unde motu lingvae exprimeretur faliva, finxiflet, fi unqvam per foramen in egreffu confpicuum vel in brutis, vel homine ftylum in ductum immififlet. Sed de his fatis, ad rem redeamus. Ill] PRODEUNTIBUS SALIVJE VASIS 25 § 16. Qyin alia dentur vafa prater jam dicta, non dubitarem, qvandoqvidem non modo a fimili ad maxillarem interiorem fita conglobata glandula in ipfam maxillarem ductum qvendam deferri, &. Whavtonus obfervarit, &. ego in vitulino capite viderim; fed etiam ab ipfa conglobata, qvam falivaris exterior includit, in falivarem derivata vafa notarim; cum tamen, qvia brevia ex exilia, diftincte non fuerint a me obfervata, in medio illud relinqvam. Hoc tamen de conglobata parotide addam, vidiffe me in agno plufcula lym* phatica in earn delata, qvae, ab extremis narium & aliis partibus anterioribus orta, fuper mufculos recto tramite deferuntur. Primam qvidem originem non licuit invenire; qvae tamen rimabar, omnia ex glandulis oris anterioribus videbantur originem ducere. § 17. Expojita fie partium illarum hiftoria, reliqvum eft, ut ad ufum deveniamus. Tres autem ufus a Doctiffimo Whavtono glandulae huic tribuuntur: 1. Nonnullas durioris rami nervi qvinti pans fuperfluitates excipeve, &■ reducere in venas, 2. aurem 6- auriculam calore fuo refo- cillare, 3.foveam Mam in amis ambitu explere &. complanare; fed non mirum, haec a Clariffimo Viro propofita, qvandoqvidem praeter vafa caeteris partibus communia nihil in ilia obfervavit; qvod ex pa* ragrapho praecedenti ejufdem capitis patet. Verum, inqvit, fi velint authores, hafce glandulas humectare partes affundendo per vas aliqvod proprium humorem peculiarem: oportet, nobis oftendant vas illud, hu= moris ab hoc oriundi fpeciem, &■ modum, qvo pars, humorem excU piens, fe qvoqve expediat. Qyod cum jam detectum fit, facile patet, nobiliori earn muneri vacare. Non video autem, qva ratione D.Blafius excufari poffit, qvi repertis frugibus glande vefcitur, qvi, licet ductus inventorem fe venditet, nihilo tamen minus, ut defcriptionem, ita & ufus ab illo affignatos fuos facit, licet mutilate: primum enim truncatum proponit, tertium omittit: namqve p. 24. Medicin. General. ait: glandulas, cum maxillaribus fubftantia convenientes, circa ra* dicem auriculae externae locum maxime habere; hinc auriculam totam cingere, ut fuperfluitates recipiant (terminos unde ex qvo reticendo), auremqve calore fuo foveant. Qyis eorum, qvi viderunt ductum fa* livae ad hanc ufqve glandulam continuatum, qvi in hac glandula infignes ductus ejufdem radices magno numero elegantiffime diftri* butas confpexerunt, credet, D. Blafium, fi ductus falivaris invefti* gationi manum unqvam admoviffet, ufus tarn ignobiles parotidibus fuiffe adferipturum, parotidibus dico, qvas, licet fubftantia cum max* 26 DE GLANDULIS ORIS & NOVIS INDE [II] illaribus convenire viderat, ufu tamen convenire non poterat fufpi* cari. Si difficilis indaginis res effet, fi vas longum & per varios anfrac* tus deducendum, fi tenerum & rupturae obnoxium, liceret varias ex* cufationes adferre; jam vero cum breve fit, cum in exterioribus ob* vium, cum denfum & robuftum magis ac aliud ullum, cum ipfe in fuis ad me litteris rem facilem &. nunqvam non obviam agnofcat, qvam bene fibi conftet, ipfe videret. Sed haec mittam. Verus paro* tidum conglomeratarum ufus, illam, qvae per ductum falivarem exteriorem in exteriorem oris cavitatem excernitur, falivam praepa* rare, qva de re, ubi reliqvas falivae glandulas defcripferimus, infra pluribus agemus. § 18. Inter eas, qvae pluribus excretoriis vafis donatae funt, primo loco veniunt, qvx in buccis reperiuntur, ut inter caeteras, turn glan* dulae, turn vaforum magnitudine, maxime confpicuae. Hae autem to* tarn buccarum regionem occupantes exteriorem oris cavitatem un* diqve ambiunt, &, furfum deorfumqve ad gingivas pertingentes, mufculos inter dx tunicam oris feruntur. Inferiore fui parte craffio* res funt, hinc tenuiores redditae, venis arteriisqve ex nervis, turn in hanc, turn in anteriora tranfmiffis, liberam per exteriorem fuper* ficiem viam concedunt. Poterat vaforum mox defcribendorum ra* tione dividi in partem inferiorem, qvae craffitie dx foliditate reliqvis prior, mediam, qvae tenuiffima, &. fuperiorem, qvae medio modo fe habet; colore cum parotide in bubulo conveniebat. § 19. Praeter dicta vafa peculiares in illis ductus 21. Maji obfer* vavi, cum craffiorem ejus partem tranfverfam paulo obliqvius diffe* carem. Hanc enim conglomeratam videns etiam, conglomeratarum exemplo, fui generis vafe donatam putabam, qvod non fefellit. Vix enim divifa erat, cum per refectum eodem ictu vafculum immiffus ftylus in cavitatem oris libere penetraret; hinc totum buccarum cor* pus ab inferiori maxilla prope gingivas refecando, ex extendendo aliqvantulum membranam, video plures in eadem recta linea exi* guos hiatus, per qvos immiffus ftylus in ipfam glandulam facili ne* gotio viam invenit. Oriuntur autem ductus, proceduntqve non uno modo. Intra craffiorem, qvae inferior eft, glandulae partem qvidam, ex plufculis radicibus in fingulares truncos concurrentibus orti, cum in via lunt capaciores, ubi ad membranam interiorem adfeenderint, fere ad gingivarum inferiorum altitudinem foraminibus illam per* tundunt qvadruplo, qvam ipfe ductus eft, anguftioribus in eadem [II] PRODEUNTIBUS SALIVAZ VASIS 27 linea fecundum totam maxillae inferioris longitudinem difpofitis: infra qvae ad aliqvod intervallum exiguae femiglobofae protuberan* tiae apparent, nullae acutae, qvae alias ad digiti fupra praedicta fo* ramina altitudinem copiofae confpiciuntur; in media qvoqve parte excretoria vafa copiofa adfunt, fed admodum brevia, vixqve, nifi per expreffum humorem, confpicienda, dum, qvae a fuperiore de* fcendunt, paulo fint manifeftiora. In homine buccarum glandulas falivae dicatas fuperiori anno ob* fervavit Clariff. Sylvius, licet vafa nondum effent detecta. Cum enim haberet aegram buccarum ulceribus laborantem, &. interdum lim* pidam inde aqvam falivae aemulam manare videret, data in Nofo* comio occafione buccas examinando, glandulofam illarum carnem nobis demonftravit. Sed dx, qvae apud Aqvapendentem leguntur de humore aqveo per relictum a curato buccarum vulnere foramen qvotidie ftillante, idem arguere videntur. § 20. Tertio loco Sublingvales fe offerunt, qvae, utrinqve ad lin* gvae latera fitae, ejufdem generis cum proxime praecedentibus funt, nifi qvod vafa excretoria obtinuerint, non qvidem breviora, fed an* guftiora. Oriuntur intra ipfam exilibus rivulis, ex, hinc fibi invicem parallela, a lingva verfus gingivas recedunt, ubi ad digiti fere a den* tibus diftantiam vix confpicuis, nifi premantur, oftiis per tunicam hiant. Nullae oftiis, nifi ad aliqvod intervallum, protuberantiae ad* funt, fed, ut in buccae vafis dictum, ubicunqve vafcula praedicta tunicam penetrant, ibi aeqvalis eft dv plana. An in papillis etiam iinuli adfint, non licuit obfervare. Compreffi aliqvot, fed nihil ex* preffi; hinc, refectas examinando, vidi, glandulofa fruffula effe, qvae reliqvas fupereminentia tunicam ibi loci in acumen elevant. § 21. Ultimas Palatinas appellare vifum mihi, cum revera tota palati caro, ut in brutis, fie ex in homine, nil nifi conglomerata glandula fit tonfillis continuata; unde innumeri exiles ductus prod* eunt, qvi, ipfam membranam perforantes, qvafi cribrum inde for* mant. Notavi illos primum 27. Maji, cum bubulum caput jam totum fere diffecuiffem ; tunc enim, cum tonfillas exfeinderem, vicina pre* mendo tenacem inde humorem excerni videbam. Hinc totum, qvod coelum oris conftituit, exfectum, digitisqve compreffum, innumeras glutinofi humoris guttulas per tenella foramina erumpentes exhibuit. Qyi a pituita palati, qvam tertiam fputi fpeciem Clar. Whartonus Adenogr. c. 22. conftituit, plane diverfus eft; qvod ex ipfius expli* 28 DE GLANDULIS ORIS & NOVIS INDE [II] catione manifeftum, dum e naribus fupra palatum illam exfugi fta* tuat, & cerebri pituitam appellet: qvod huic minime competit. Cum in illo jam effem, ut praefentia typographo committerentur, accepi Clariffimi Schneideri De Catarvhis librum tertium, ubi ille feet. 2. c. 3. mentionem facit membranx pituitarix in extremo palato obfer* vatae, unde pituitam exiudare vidit. Revera autem, praeter membra* nam ipfam pluribus foraminulis pertufam, glandulofa caxo fub tota ilia membrana reperitur. EXPLICATIO FIGURARUM Fig. I. a. Pawtis conglomerata. b. Parotis conglobata. c. Lymphaticum ex conglobata deorfum tendens. d. Radices ductus falivaris extetioris. e. Truncus ductus falivaris. f. Venx jugulavis rami exteriores. g. Nervi, qvi, ut intra glandulam &. caput, fie &- extra ilium locum, ut in h. fibi innectuntur. i. Nervei funiculi ductum falivarem comitantes. Fig. II. a. Oftia vaforum, a glandula buccarum inferiori prodeuntium, qvorum nonnullis feta immijfa eft. b. Apertio ductus falivaris extetioris in papillarum fumma &. poftrema occurrens. Reliqva puncta in= nuunt cxtera foramina, per qvx compreffione vifc= idus humor exit. „, Fig. III. a. Glandula fublingvalis. b. Vafa ejus. c. Vaforum excretoriorum ofcula. d. Sinus ad latus lingvx obfervatus. Fig. IV. a. Foramina palati, per qvx lentus humor exprimitur. b. Tonfillx. F.g v Vafculum unum ex illis, qvx e glandulx bucca- rum inferiore parte prodeunt. [II] PRODEUNTIBUS SALIVAZ VASIS 31 § 22. Vidimus hactenus glandularum Jiomaticarum hi/loriam, de qvarum vero ufu non eft, qvod multa addamus. Cum enim vafa peculiaria fint detecta, nemini dubium effe poteft, qvin illarum mu* nus fit, qvi in ore perpetuo reperitur, humorem prxpavare. Ut autem in ore cum inferioribus fuperiora, interiora cum exterioribus ma* defierent, plura data funt vafcula ad humorem omnibus aeqvaliter communicandum, per qvae etiam, qvando opus, copiofa excerni po* terit faliva. Sic raram inter alias hiftoriam refert Clariff. Bartholinus de nobili, qvi, qvotiefcunqve cibum fumit, larga fputatione labo* rat, extra illud tempus nihil, neqve inter loqvendum, exfpuens, etiam fi liberalius qvandoqve amicorum in gratiam invitatus potet. Non itaqve opus ad occultas confugere vias, ut, qvi in falivationibiis, vel fponte qvibufdam in morbis fubortis, vel apophlegmatifmorum ufu provocatis, excernitur humor, inde derivetur. § 23. Mafticatoria enim qvod attinet, five palato illinantur, five dentibus agitata ore detineantur, non poterunt non fubtiliores partes caloris diffundentis ope per aperta foramina in glandulas brevioribus vafis excretoriis inftructas penetrare, ex vifcidi humoris promovere fecretionem. Sic ex in nares attracta errhina, ex glandulofas partes, qvae ibi reperiuntur, penetrantia, ad ferofi humoris eductionem mul* turn conducunt. Nee eft, qvod miretur qvis, me per idem vas ex in glandulas medicamentum ex ex illis excrementum deducere. Cum enim vafa excretoria patentia fint & brevia; cum medicamenta hoc agentia acria, fubtilium partium, dx calore facile mobilia: non pot* erit nee illorum difpofitio, nee horum vis in dubium vocari. § 24. Qvod Salivationes, qvibus morbi interdum folvuntur, fpec* tat: videtur etiam illarum explicationem praedictorum vafculorum con* fideratio clariorem reddere. Qyam enim Celeberrimus Vir Carol. Pifo De Morbis a Serof. Coll feet. 1 . theor. 4. ex capite per membranas ner* vosqve glifcere ex depluere aqvam putat, ex praedictis glandulis puta* rem derivandam: fie feet. 2. part. 1. c. 2. refert, fplenetico ex fpu* tatori perpetuo tumuiffe interdum genas infigniter, fed indolenter, eumqve tumorem dialem fere, vel infenfibiliter, vel cum plurima falivatione, folutum. Et paulo poft ait: tumores genarum, ut ex glan* dularum auriculas circumjacentium, nee non glandularum colli in* dolentes, vel ab apricatione, vel a frigore autumnali excitatos, ex paucas intra horas in immanem molem excrefcentes, interdum diem intra naturalem folvi, vel infenfibiliter, vel cum multa fpuitione. 32 DE GLANDULIS ORIS & NOVIS INDE [II] Scilicet hae partes, aeri partim extrinfecus ambienti, partim interi* ora oris, dum refpiratione attrahitur, lambenti expofitae, facile ab illius injuriis in fubjecto difpofito afficiuntur; qvod fi itaqve in hifce a calore frigoreve affectis partibus detineatur materia qvaedam, mas nifeftae adfunt viae, per qvas inde poterit excerni. § 25. Magnum autem dubium de origine humoris ora rigantis occurrit. A cerebro alii per occultas vias, alii a fucco per netvos delato, qvidam a fangvine arteriofo, Nobil. Biljius & Biljio favens Clariff. Anton. Deujingius in Exercitat. Phys. Anatom. de Alimenti in Corpore Depur. § 83. a rorifero fucco, per vafa communiter lymphatica dicta advecto, ilium derivant. Nos in praefens hoc tantum agemus, ut oftendamus, fangvinem arteriofum huic muneri aptum effe; nervos autem, aliis ufibus deftinatos, non fruftra glandulis datos; lymphae vero, feu rorifero fucco, ilium ufum non, nifi reclamante omni ex ratione ex experientia, poffe attribui. Qyod anteqvam aggrediar, de ipfo humore pauca tantum praemittam, cum uberior ejus confide* ratio Chymicam Anatomen reqvirat. § 26. Videtur autem, qvi in ore naturaliter reperitur, humor omnis Jalivx nomine commode poffe infigniri, cum aliud magis proprium fe non offerat. Qyi enim fputum vocant, non eum, qvi naturaliter adeft, fed qvi naturae moleftus excernitur, ilia voce exprimunt. Hie autem, de qvo agitur, melioris notae eft, qvam qvi excerni debeat, fi qvis alias intra diaetae limites fe continuerit. Qyod illorum exemplo patet, qvi nunqvam in vita per nares aut ora qvicqvam excrever* unt: Inter qvos primarii fuere Perfae; vojiijuov yap br\ fyv avxolq unje JiTueiv, unre &:rco|Lii3rr£C\)>cu . Qyippe frugalibus, ex femel tantum in die cibum affumentibus, lex ea obfervatu facilis erat. Di* vini namqve Hippocr. authoritate: juu<~cu xai OieXa 7rXn,a|uovfiq £CTi xpiGic;, a qva repletione nullum ipfis periculum erat. § 27. An faliva omnis ejufdem naturae fit, dubium videretur, cum non uno in loco omnis praeparetur. Si glandularum vaforumqve, qvae turn afferunt, turn efferunt, fpecies confideres, nullam agno* fees diverfitatem. Conglomeratae namqve omnes funt, ex in omni* bus ejufdem generis vafa reperiuntur; tria tamen funt qvandam diffe* rentiam arguentia. 1. Color, qvi non omnibus glandulis femper idem; rubent interdum parotides, dx in buccis fitarum inferior pars, fu* periore cum tonfillis, palatinis dx fublingvalibus ad flavum inch* nante, cum maxillaris inferior ut plurimum palleat. 2. Vaforum con- [II] PRODEUNTIBUS SALIVA VASIS 33 formatio, qvibufdam enim glandulis unicum duntaxat eft, ut maxil* larium inferioribus, ex illis, qvae fub auribus reperiuntur: aliis plura, eaqve vel exigua, ut palatinis, tonfillis &. buccarum fuperioribus; vel aliqvanto longiora, ut in fublingvalibus &. inferioribus bucca* rum. 3. Humoris conjijientia, qvi in longioribus vafis minus, in bre* vioribus magis vifcidus reperitur. Sed cum coloris ilia diverfitas fem* per locum non obtineat, vidi enim in vitulo, hinc 6, in agno, om* nes eodem pallore inlignitos; cum confiftentiae difformitas non in omnibus eadem, expreffi qvippe non femel ex ductu magno, tarn fuperiori qvam inferiori, materiam lentam ex tenacem: relinqvitur vaforum diverfitas in lola magnitudine confiftens, unde contenti diverfitatem inferre non licebit. § 28. Si, ut ex ore prodit, infpiciatur faliva, colore cv perfpi* cuitate aqvae aliqvantulum cedit, cum radii lucis in ilia, qvam in aqva, paulo majorem fubeant mutationem; qvae autem fpumofa ex* fpuitur, non fibi, fed lingvae ex oris motui hoc debet, cum eodem modo lac, cerevifia, imo ipfa aqva fpumofa effet dicenda; digitis fi explores, lentam fenties ex vifcidam, atqve lubricandi vim ha* bentem, ideoqve aqva minus mobilem, magis difficulter divifibi* lem; faporem in fanis nullum invenies, ut nee odorem. Qvam ita* qve fapor ex odor ctTTOiov judicant, earn vifus ex tactus aqva mi* nus fimplicem decernunt: cv revera, fi alios efTectus confulere placet, Gngularem in ea compofitionem animadvertere licebit. Simplices liqvores, qvales in naturalium examine occurrunt, non nifi fui, aut medii generis, alia facile fibi patiuntur admifceri; c\ fi forte hete* rogenea qvaedam, non mediante tertio, agitatione qvadam illis fue* rint confufa, ftatim fibi relicta, vel, fi frigore juncta, leni igni im* pofita, aut, fi majori calore commixta, refrigefcentia, farcinam non convenientem deponunt. Sic aqva, falem praeter ex fpiritum, aut his contemperata, nihil fibi patitur admifceri: admittit eadem oleum, fed oleum aqvae fine medio qvi conjunxerit, nondum repertus. Spiritus aqvae cv oleo jungi poterit, non autem fali, nifi fingulari artificio, qvod inter arcana artis Chymici fibi refervant; patet hoc, fi oleo tartari per deliqvium fpiritum vini rectificatum affundas, utcunqve enim agitaveris, ftatim fumma petet fpiritus, tartaro ad imum detrufo. Salfis acida facile mifcentur, fed, fi exqvifite talia, non fine effervefcentia. Saliva vero omnia ferre valet. Sive enim intra corpus, five extra examinaveris, nihil invenies, qvod ilia re* 34 DE GLANDULIS ORIS & NOVIS INDE [III fpuat, nihil, cui fine pugna non affocietur. Hinc ex ore affumenda qvaevis illi, tanqvam univerfali menftruo, primo ftatim ingreffu jun* guntur; hinc ex ventriculo contentis ilia continuo, nobis ne atten* dentibus qvidem, deglutita jungitur, ut alimentorum diffolutio pro* moveatur. Effe itaqve non fimplicem liqvorem, fed mixtum, idqve fingulari proportione, ex ante dictis patet. Sed ex alia in promptu funt argumenta, qvibus, non fimplicem effe liqvorem, demonftratur: namqve ex evaporatio falem mihi (cum mane aliqvando vitro ex* ceptam, qvae limpida, ex ab omni muci confortio liberata erat, ig* nis examini fubjicerem) exhibuit; ex Mercurii mobilitas ab illius commixtione impedita, qvam mortificationem vocant, oleofi acido temperati praefentiam arguit; ut nihil de variis viribus in Medicina decantatis, qvae fine principiorum activorum virtute non Sunt, fub* jungam. Non poffum itaqve, qvin Clariffimi Sylvii in humorum corporis noftri examine chymico, non minus qvam in corporis ana* tomica refolutione verfatiffimi, fufpicionem magis qvam probabilem effe admittam. Ille namqve exiftimat, effe in faliva multum aqvx, pavum fpiritus volatilis, &■ minimum falis lixiviq/i, cum olei fpiritusqve acidi tantillo mixti temperatiqve. Qyod variis exemplis latius poffet explicari, nifi inftituti noftri ratio alio nos vocaret. § 29. Examinata fie cum glandulis faliva, reliqvum eft, ut vias materiam ejus advehentes indagemus. Qyod ut commodius fiat, par* tes, cum qvibus glandulae commercium habent, fingulas propone* mus, |a;r£pcuvouEvcov juf| ein, £:raupac8'cu, tgjy be (be; epyou evbeil-ioc;. Sed magis adhuc miror, qvod Biljii de mefaraicarum ufu experimento tantum tribuas, ut contra CI. Bartholinum fufcipias defendenda, qvae nunqvam nee tentafti ipfe, nee ab aliis vidifti tentata. Difputas de colore rei, qvam te non vi* diffe affirmas, ex qvem alii »rp fwarf appellant, parum tantum nigri* cantem interpretaris. Sed certus fum, te, ubi ilia expertus fueris, longe alia mente futurum. Feci experimentum in amicorum prae* fentia, obfervavi praefcriptam a Bilfto methodum, ligavi arterias, detinui in vivis canem primum per tres, alterum per qvatuor horas, qvi vel integrum diem ita vixiffet; confutum dein ventrem iterum diflecui, eductum ex porta, cava, aorta fangvinem aeri expofui, fed aeqve cito concrefcebant, fplendebant aeqve, aeqve nigricabant. Qyid igitur inde concludis? Sed ex ratio Biljii, qva probat, contentum in portae ramis fuccum cum fangvinis natura affinitatem habere, gratis affertur, cum non modo hoc largiamur, fed ex effe ipfum fangvinem ultro concedamus; nihil itaqve ilia ratione agit. Nee, qvae de colore denfo, fubobfeuro, obfeuro, cinericeo infert, qvicqvam probant; examina, qvaefo, eductum venae fectione fangvinem, ex vide, qvam varios in variis fubjectis obfervare liceat colores. Sed haec mitto. Cum itaqve pateat, nee Prxjidis effe, qvorum nomine leni ilium correctione tangere voluifti, tetigifti autem acriter, nee ullo jure, qvae de chyli per mefaraicas rubras motu affers, hie locum habere: oportet, ut omnia, qvibus eum perftrinxifti, in me tranfferam, ix dicam, mutato nomine de me omnia narrari. Sed nee me, qvae objicis, meruiffe, oftendere mox aggrediar, ubi in anteceffum monuero, me omnia, qvae affectibus tuis, non forfan tibi ipfi, deberi, aeqvus lector judicabit, qvalia funt ofcitantia, imprudentia, oculi diftorti, obliqvus intuitus, iniqva difputatio, ix qvae caetera vel abfolute, vel fub con* [IV] RESPONSIO AD VINDICIAS HEPATIS REDIVIVI 65 ditione pofita, haec inqvam, omnia tranfiturum, £x ipfa rerum mo* menta candide expofiturum; qvid enim ejufmodi verbis efficitur, qvam ut magis magisqve commoveantur animi, atqve ita res ipfa non ea, qva decet, attentione examinetur? -ffigre ferrem, fi in the* fibus vel unicum verbum de te pofuiffem a commoto animo pro* fectum: fed nee de Biljio aliud dixi, qvam qvod ipfe, fi cum eo fueris locutus, non negares; idcirco dixi, indolem ejus ex fermo* nibus ex fcriptis dignofcendam, qvid autem funt haec ad ilia, qvibus adeo acerbe fine omni ratfone Barthol., Praeceptorem meum, agref* fus eft? Qyod vero, qvae ego Biljio, tu tibi attribuis, qvo jure id agas, non video. Non dixi, te omnibus illius favere, fed qvibuf* dam, ex qvis vitio mihi verteret, fi ego in re, qvae vera, affen* fum praeberem homini vel omnium hominum perditiffimo, ideone etiam ego ejufdem farinae effem cenfendus? Ne putes, Clariff. Vir, qvenqvam aeqvum rerum arbitrum (de aliis non loqvor, cum etiam optime dicta peffime liceat interpretari) ilium, qvo Biljium profeqveris, favorem adeo late extenfurum, ut etiam Bilfii vitia tibi fit adferipturus. Sed ex irafci mihi parce, qvi de te nihil dixi, nifi qvod ex fcriptis tuis cuilibet eft manifeftum. Dixi thef. 25: Nobil. Bilfius &. Bilfio favens Clar. Anton. Deufing.; thef. vero 42: cui de faliva opinioni affenfum prxbet Clar. Ant. Deufing. Qvid in his ver* bis tali cenfura dignum? Qvae hie caufa tales fingendi fufpiciones? Qvod fi ipfe te Biljio favere dicas, fi partes ejus, in qvantum tibi videntur verae, contra adverfarios fufcipis defendendas, qvid in me excandefcis, qvod, qvae ipfe profiteris, ego dicam? Nimis arctas fcribendi leges nobis figis, fi, ubi de re agitur, authores teftes ad* ducere non permittis: qvi p. 30. ais: Qvid mifceor pevfonis, ubi de rebus agendum? Qvid fi ad hanc legem tua examinarentur? Sed qvantum video, in eo erravi, qvod dicendum fuiffet, non te Biljio, fed ilium tibi affenfum praebere, ut p. 28. liqvet: Qvamvis certe hie potius, ubi vere confentimus, fentiat nobifcum, nojlrasqve fententias pafjim, etiam ante Bilfii nomen evuditis cognitum, publice expojitas, videatuv fuis experimentis confirmare; qvafi vero etiam de eo certan* dum effet, uter dicendus alteri affenfum praebere, nee utriqve aeqve convenire poffet. Fac, te mentis oculis ilia primum vidiffe, Biljium autem oculis corporis eadem primum obfervaffe, nonne eodem jure experimentis ejus affenfum praebere diceris, qvo tuis ille rationibus? Notum omnibus, Biljium tua nunqvam legiffe, fed ex te, qvae ejus 66 RESPONSIO AD VINDICIAS HEPATIS REDIVIVI [IV] funt, nunqvam vidiffe, affirmas: qvid igitur refert, uter alteri affen* fum praebere dicatur, maxime cum ex tua ratio ex ejus experientia in illo cafu ejufdem fint ponderis? Sed mittam haec, ex eo pergam, ubi verba ex fenfum detorfiffe dicor, oftendamqve, me Bartholin! tuamqve 6, Biljii mentem per* cepifle, nee aliter ac eft propofuiffe; qvod ut fiat, meum prius ex* ponam, neceffe eft, fenfum, fimulqve dictorum occafionem. Boni enim interpretis eft, non ipfa modo verba feorfum confi* derare, fed ex cum antecedentibus fimul ex confeqventibus conferre. Praeftat enim, ubi de re agitur, fenfum authoris integrum, qvam ipfa ejus verba proferre, nifi ex, qva occafione eadem verba fuerint prolata, ubi opus, fubjungatur. P. 31. ais: Viv candidus ipfa ali* ovum verba proferat, qvos vult laudare, vel repudiare (fie ago cum aliis, dum veritatem inqviro) vel faltem non detorqveat &- verba &■ fenfum, nee dubiis locutionibus prxjudicia creet. Videamus itaqve, uter noftrum magis candide egerit, tu ne, qvi ipfa aliorum verba pro* fers, an ego, qvi eorundem fenfum. P. 19., ut probes, Bartholin num iniqva conditione a Bilfio flagitare demonftrationem motus chyli e lacteis ad hepar, ipfa Bartholini verba ex Spicileg. 2. adducis, ubi ipfe ftatum qvaeftionis determinat; de motu chyli per mefaraicas ad hepar, qvem negat, hinc p. feq. ita infers: Qyod fi autem ifie fit flatus controverfix , exponente ac confitente ipfomet Bartholino, qvid pofcit a Bilfio, ut demonflret fibi ingreffum chyli in hepar per lacteas venas, qvo ad refurrectionem hepati aditus pateat, feu fangvi= ficationis munus eidem ajferatur? An non iniqva conditio efl, dum Bilfius promittit, fe demonftraturum chyli immediatum ex ventriculo feu intefiinis in hepar ingreffum per mefaraicas rubras (qvem pernegat Bartholinus) ab ipfo poflulare, ut demonflret chyli in hepar ingref* fum per lacteas: qvem motum chylo, feu fucco nutritio, de qvo fob qvxftio eft (non de lympha feu rore), ipfa negat natura judice Bilfio? An fcopum ferire ilia conditio cenfenda, Jub qva demum affenfus re* furrectioni hepatis baud difficilis promittitur? Qyis lectorum, qvi Bartholini Spicilegia non evolvit, hifce tuis verbis fidem non adhi* bebit, ex credet, Bartholinum fibi ipfi contrarium, vel fui oblitum in Spicileg. 2. talem controverfiae ftatum formaffe, in Refponfione autem longe alia poftulare? Qvi vero ipfum Spicilegium infpexerit, qvi viderit, Bartholinum duo fibi fumere refutanda, &, in prioris examine occupatum, dum videt, ex primo experimento concludi [IV] RESPONSIO AD VINDICIAS HEPATIS REDIVIVI 67 id, de qvo non qvaeritur, dicere: & qvanqvam chylum fangvini com* mvctum cum aliis lavgiremur, id tamen hoc loco non qvxrituv. Qyxftio eft, an fuccus Me nutritius, chylus dictus, ex ventriculo cor primum petat &c; hoc vero refutato alterum membrum aggredi, £x de lym* phae motu varia, qvae fuo loco afferemus, proponere: videbit facile, ftatum controverfiae in primo membro formatum longe diverfum effe ab eo, de qvo in fecundo agitur, nee ad ilia de lympha redu* cendum. Qyod fi itaqve verba tua fecundum veri interpretis leges forent fupplenda, talia effent. Qyod fi autem, ubi de mefaraicarum rubrarum ufu cum Biljio difputat Bartholinus, ifte fit ftatus contro* verfiae, exponente & confitente ipfomet Bartholino, qvid, cum de lactearum ex lymphaticorum ufu agitur, pofcit a Biljio, ut demon* ftret fibi ingreffum chyli in hepar per lacteas, qvo ad refurrectio* nem hepati aditus pateat, ex fangvificationis munus eidem afferatur? Atqve ita videbit qvilibet, qvi Epijiolicam Biljii Dijfertationem legit, qvi occafionem Exfeqviarum Hepatis novit, aeqvane an iniqva fit ilia conditio, qvam Biljio proponit Bartholinus, de qva infra pluribus. Sed dx fimul obfervabit, qva fide Bartholini verba fuerint adducta, &. an femper tutum fit credere illis, qvi, qvae de aliis proferunt, ipfis illorum verbis probant. Multa enim aliorum refpectu vera funt, qvae per fe pofita funt falfiffima, fie refpectu primi membri a Bartholino in Spicileg. 2. refutati verum eft, hunc effe ftatum con* troverfiae, fi vero abfolute fumas, neqvaqvam verum. Ut enim duo praeter communem opinionem afferit Biljius, fie &. duo diverfi funt ftatus controverfiae, ex dum hoc loco hunc effe ftatum controverfiae dicit, non negat alio loco alium effe. Invitus hanc de interpretis munere controverfiam moveo, qvam filentio involviffem, nifi tuae illam Vindicix, qvafi vi, mihi extorfiffent. Ut enim oftendas, me finiftre interpretatum tua verba, verba tua in alienum fenfum de* torfiffe, exc, ipfa verba Bartholini, Biljii, tua, mea profers, atqve ita apud lectores, qvi qva occafione fingula fuerint dicta, ignorant, fidem ftatim invenis; ut itaqve illud a me crimen removerem, prius modus, qvo in me uteris accufando, erat examinandus. Jam autem in thefibus a me propofita aggrediamur, & videamus, egone tua verba in alienum fenfum detorferim, an tu potius mea minime fueris affeqvutus. Cum Difputatione de Glandulis Oris &■ nuper Obfervatis inde Prod= euntibus Vajis Prima hiftorice omnia propofuiffem, reliqvum erat, 68 RESPONSIO AD VINDICIAS HEPATIS REDIVIVI [I VI ut &. de ufu qvaedam fubnecterem ; hinc fecundam addidi, ubi fta* tim in initio, qvod ex obfervatis fponte fluebat, propofui, glandu* latum munus ejfe eum, qvi in ore perpetuo reperitur, humorem praz* parare; adjunxi etiam exempla, ut oftenderem, ad alias vias falivam in os immediate deponentes non recurrendum. Jam reftabat qvae* rendum, unde mediate faliva effet deducenda, qvod maxime du* bium; a glandulis enim in os prodire ad oculum demonftrare licet, unde autem oriatur ille in glandulis praeparatus humor ex ora rigans, non item. Poterit enim a cerebro derivari, ex qvidem vel per nervos, vel alias vias occultas; poterit a corde deduci per arte* rias; poterit etiam a glandulis advehi per lymphatica. Hasc thef. 25. enumeravi; &. cum haec de lymphaticorum ufu opinio recen* tiffima effet, patronos ejufdem nominavi, primum fcilicet authorem Bilfium, ex huic in praefenti negotio affenfum praebentem Deufin= gium. Ut autem manifeftius evadat, me thef. 25. agere de viis in glandulas, non in os, adducam ex thef. 29., ubi, qvod priori me acturum promifi, aggredior: Examinata fie cum glandulis faliva, re= liqvum eft, ut vias materiam ejus advehentes indagemus. Qvod ut com* modius fiat, partes, cum qvibus glandulx commercium habent, Jingulas proponemus, &■ qvibus mediis vel aliqvid inde accipiant, vel eo mittant, inqviremus, ut fuus Jingulis attribuatur ufus. Hinc feorfum cor, nervos, glandulas conglobatas examino, qvemadmodum thef. 25. pollicitus eram. Thefi vero 42., ubi ad Bilfium deventum, dixi, eum humores in corpore aqveos ipfamqve falivam a ductu rorifero, non autem a fangvine, derivare, teqve illi in hac de faliva opinione affenfum praebere. Scilicet cum dx Bilfius, e glandulis immediate falivam oriri, ftatuat, mediate vero e ductu rorifero, cumqve ipfe, qvam e glan* dulis maxillaribus promanare, ais, aqvofam materiam ad glandulas per ramos roriferos ordinarie (de ordinario autem affluxu hie tan* turn loqvimur) deferri videri, dicas, fangvinis autem nullam facias mentionem, qvid manifeftius, qvam te illi in hac de falivae mediata origine opinione affenfum praebere? Sed his non confideratis Vin« diciarum p. 23. primo, an non potius Zaffii fenfum pro Bilfii mente fubftituam, dubitas, hinc propria verba proferendo oftendis, te non unam, fed vel triplicem falivae materiam conftituere, adeoqve con* qvereris tandem, qvod, non obftantibus verbis adeo manifeftis, dica* mus, te Bilfio tavere, atqve affenfum praebere hujufce de faliva opi* nioni, qva nimirum hanc unice a rorifero fucco per vafa communiter [IV] RESPONSIO AD VINDICIAS HEPATIS REDIVIVI 69 lymphatica dicta advecto derivat. Qyod primum attinet, de re non dubia dubitando, te necdum Biljii mentem percepiffe, oftendis. Qyid enim clarius, qvam eum falivam reliqvosqve humores aqveos inde deducere? Videamus Epi/iolicam ejus DiJJertationem, ubi de ductus roriferi diftributione ita loqvitur: Et ne diftingvam omnia, deniqve in glandulas fputuitarias, lacrymales, pituitarias cazterasqve omnes 6- ubique influit, aut tevminatur. Et circa finem de rore fuo: Id qvidem per ceptu facile erit,Jijam lacrymas, phlegmata, falivas, fudores, capillos, ungves ah Mo pvovenive, totumqve corpus nutritioni ejus irroratione aptum reddi, omniaqve natural fermenta ex eo derivari, ad oculum ojlendatur: Qyod qvidem fiet, &c. Qyis hie dubitandi locus, ubi verba funt adeo manifefta? Qyod vero fecundum fpectat, qvae non negavi, tanqvam negata, probas. Loqvor de praeparata in glandulis faliva, qvam, te a lymphaticis, non autem ab arteriis, deducere, ipfa tua verba oftendunt, tu autem, ac fi de viis falivam in os im< mediate deferentibus egiffem, plures te adduxiffe, probas, qvod a te factum non negavi. Qyod fi itaqve aliqvid obtinere vis, hoc tibi probandum : te cum Bilfio fecretam in glandulis falivaribus fali= vam a roriferis ramis ordinarie non deducere unice, fed a fangvine. Dum vero credis, te partem falivae a fangvine deducendo mihi affenfum praebere, a mente mea multum recedis. Duas enim falivae vias immediatas proponis, ductus falivares puta ex arteriolas, feri* qve aqvofiorem portiunculam per arteriolas ad os ex palatum ex* fudantem ab ilia, qvae a glandulis procedit, diftinctam vis; cum ego arterias non immediate ad os deducam, nee falivaribus due* tibus opponam, fed fubordinem tanqvam vafa illis materiam fub* miniftrantia. Nihil itaqve minus, qvam mecum fentis, qvi feri ex arteriis exfudationem , qvalem hie innuis, ex Clariff. Schneid. torn. 3. feet. 2. c. 3. p. 509. expreffe defcribit, necdum a qvoqvam vidi probatam, adeoqve pro mero ingenii foetu judico habendam. Omnibus enim in locis, qvae laudatus modo Vir Celeberrimus p. 554. catarrhorum pro fontibus habet, glandulofas carnes etiam ante vifum mihi tomum ejus tertium obfervavi, &. amicorum oculis fubjeci. Sed ex in epiglottide non glandulae modo, fed etiam ex* cretoria vafa per ipfam cartilaginem in partem oppofitam penetrantia accuratius ea examinanti manifefta funt, ex in narium tunica ad latus illius ductus, qvi a punctis lacrymalibus ad anteriora narium defertur, aliud excretorium vas a minutis iftis glandulis ortum 70 RESPONSIO AD VINDICIAS HEPATIS REDIVIVI [IV] nuper obfervavi, ut adeoqve veros catarrhorum fontes conglome* ratas glandulas nobis praebere exiftimarem, qva de re alibi, fi Deo ita vifum, fufius. Sed neqve dum falivae diverfam naturam agnofco, &. humorem mixtum profiteor, te mihi potius qvam Bilfio faven* tem invenio. Non enim inde feqvitur, me aliud, praeter fangvinem arteriofum, ad partes vocare. Non feqvitur: Saliva eft humor mix* tus, ergo non a folo fangvine eft. De tertia falivae materia, qvam a cerebro ad glandulas defluere ftatuis, thef. 22. dixi, nos fruftra ad occultas vias confugere, cum adfint manifeftae. Multas qvidem a cerebro in os ex hinc viciffim in cerebrum patentes vias recenfet Clariff. Falckenburgius in Epiftola ad Johannem Neandrum de Tabaci Fumo, fed videtur offa capitis denudata potius, qvam ipfum caput omnibus partibus inftructum confideraffe. Non negabo, poffe tales reperiri vias, fed nee adeffe credam, anteqvam adeffe videro. Qyod fi itaqve vel ratione qvadam inexpugnabili, vel experientia certa ejufmodi meatus a cerebro in os oftenderis, magnam apud omnes veri cultores inibis gratiam. Cum itaqve nee ex cerebro in glan* dulas, nee ex arteriolis in os qvicqvam immediate deferri ftatuam, fed ex arteriis in glandulas, patet, te nulla in re mecum fentire; cum autem, qvod in glandulis falivaribus fecernitur, per ramulos roriieros ordinarie adferri videri dicas, fangvinem reticendo, om< nibus manifeftum eft, te Bilfio affenfum praebere. Eadem thefi 42. expofita Bilfii de lymphae motu fententia, ad* ductoqve, qvo ille femper provocat, experimento, addidi, hunc ejje chyli motum, qvem fibi demonfirari in Spicilegio 2. D. Bartholinus cupit, qvem Bilfius in Epiftolica Differtatione adfiruit, qvem D. Bor* richio, me praefente, in vivo cane voluit demon/hare, ut mirer, D. Deufingium, in chyli nomine ex Bilfii mente explicando occupatum, Bartholinum iniqvx pojlulationis accufare. De illo enim humove to- qvitur, qvi in lacteis mefenterii continetur, &. qvem inde ex parte per lymphatica in hepar deferri Bilfius demonfirandum fufcepit. Non hie paria illis, qvibus me in horum examine aggrederis, referam: dixi enim, me tuis haec affectibus, non tibi, adferipturum; nee agam de CtxvpoXoyict, qvam ita fufe taxas, cum omnibus, qvi vel epiftolas Veterum triverunt, notum fit, amicos fe invicem in lirteris inviolata amicitia accufare, nee vocem accufandi adeo arctis inclufam effe limitibus; ix mollias, qvantumlibet ilia de iniqva conditione, qva, qvod non promifit Bilfius, Bartholinus ex tua fententia flagitat, [IV] RESPONSIO AD VINDICIAS HEPATIS REDIVIVI 71 explicesqve qvam amicifGme, me fane repugnantem nunqvam in* venies. Nee enim eo haec fine unqvam propofui, ut te Bartholino invifum redderem, cum fciam, genus hoc proxenetarum Diis ho* minibusqve invifum effe. Sed his miffis oftendam, Bartholinum nihil nee in Spicilegio Secundo, nee in Refponjione de Experimentis Ana= tomicis Biljianis (cujus loci citatio in thefibus fuit omiffa) poftulaffe, qvod non promifit Biljius, ut adeoqve omnibus patere poffit, te in re clara verbis obfeuranda neqvicqvam occupari. Videamus Bar= tholini verba. Cum Spicileg. 2. cap. ultimo p. 100. ex feq. de chylo ex lympha Biljii mentem expofuiffet, dx fingula examinaffet, tandem in fine tractatus addit: Eo vero (fcil. rore) totum corpus nutritioni aptum veddi, iworatione &■ fermentatione , pvomittit, fe aliqvando ad oculum demonftraturum. Qvanqvam de tore folo, Ji a chylo difiingvatur, non repugnarim, qvia tamen aliter Mi vifum, nos magno dejiderio ijxas demonjlrationes exfpectabimus, ut proprius remoto velo intueamur, qvid Nobilijfimo Viro Natura revelaverit, & ut fidem fuam brevi ex" folvat, qvanto pojfumus officio, rogamus. Optamus, ut fufcepti negotii curfus illi arrideat, &c. In Refponf. autem p. 10. ait: Nee animum ob=> firmabo facilis ad applaufum, Ji iftis Anatomise Profejforibus, prxter alia, demonftraveris chyli ingrejjum in hepar, fed immediatum ex venis lacteis, non rubris mefentericis per longas ambages, qvibus cum fangvine mixtus, chyli propriam appellationem amifit. Qyis aeqvus rerum arbiter non videt, Bartholinum hie ejus, qvod in lacteis con* tinetur, motum fibi petere demonftrari, maxime cum adeo expreffa habeantur verba? Scilicet in primo loco loqvitur de roris diftribu* tione totali in totum corpus, in fecundo de ejufdem diftributione partiali in hepar. Qyid autem Ros hie aliud Bilfio, qvam contentus in lacteis mefenterii fuccus? at hunc, qvotiefcunqve lac referre vifus eft, chyli nomen a prima lactearum inventione obtinuifle qvadra* ginta fere annos omnibus notum. Non hie repetam fuperius dicta, qvo jure ilia de ftatu controverfiae Bartholini verba contra me adduxeris, qvafi in Spicileg. 2. tantum de vafis mefaraicis rubris ageretur, cum cuilibet Spicileg. pervolventi patere poffit, etiam de lacteis & lymphaticis qvaeftionem effe, unoqve pofito alterum non excludi; fuffecerit mihi oftendiffe, Bartholinum non modo in Refp., fed ex in ipfo Spicilegio de contento in lacteis fucco agere, ejusqve motum fibi petere demonftrari. Hunc autem aliorum ex mente chylum, fecundum propriam vero opinionem rorem, a lacteis ex 72 RESPONSIO AD VINDICIAS HEPATIS REDIVIVI [IV] in hepar &. in reliqvum corpus deferri demonftraturum fe pollicetur in Epifiolica Dijfertatione Bilfius. Pergo igitur, inqvit, liqvov ille, qvem ab ufu rorem dicimus, venas lacteas per earum in inte/iinis aperta ofcula invadit, &■ feorjim congregatis canalibus in duas fe vias divU dit, ilia ad glandulam, qvx venae porta? affigitur, ducit, atqve inde vafa lymphatica propagat jecori: altera in glandulofo mefenterii receptaculo convenit, unde totum corpus ramis evidentibus inferius fuperiusqve infiaurat, &c. Sed, dicas, de refurrectione hepatis agitur, adeoqve de veri chyli & proprie ita dicti motu, Bilfius autem, lactearum contentum chylum effe, pernegat; hinc addis p. 17: Interea vero, ne credat Vir Clariff., adeo vecordem effe Bartholinum, qvi velit fe facilem prxbere in admittenda hepatis refurrectione, fi modo ipfi pro* betur a Bilfio, humorem ilium, qvi in lacteis mefenterii continetur, qvem a lympha Bilfius non difiingvit, per ipfa ilia lactea feu lym= phatica vafa in hepar deferri: cum ne ipfe qvidem Bilfius ilium hu= morem idoneum agnofcat, ex qvo fangvis qveat generari. Sed, qvan* turn video, Exfeqviarum Hepatis occafionem aut ignoras, aut igno* rare te fimulas: hanc enim fi confideraffes, in ilia nunqvam verba erupiffes. Infpice enim, fi placet, c. 8. Vafi Lymphat. Barthol. in Animantibus Inventorum, ubi inter alia ita loqvitur: Igitur fi qvidem vafcula nonnulla circa hepar femper obfervavi, hactenusqve pro lacteis habui, jure jufio, donee aliud perfvaderet Naturx favor, chylum ad hepar partim difiribui, partim ad cor exifiimavi: jam vero, qvia primis nobis Hafnix tarn nuper licuit ejfe ocularis, ut, qvid fint vafa ilia exilia, unde progrediantur, qvem ufum prxfient, in animalibus diligenter evifceratis invefiigaverimus, noluimus antiqvatx opinioni obfiinatius in= hxrere, aut labantes hepatis derelicti partes diutius feqvi. Vidimus qvippe vafa ilia prope hepar ejfe fui generis, a contento liqvore Lympha* tica nobis dicta, ex hepate ad receptaculum aqvam inferre, ligataqve intumefcere prope hepar, adverfa vinculi parte inaniri, fimiliaqve ejfe &. fubfiantia &■ colore 6. contentis & ufu illis, qvx ex artubus &■ in= fimo ventre alias primi aperuimus. Hoc invento novo fpe omni fan= gvificationis excidit tot feculorum applaufu decantatum hepar, qvod ne falus ipfa fervaret amplius, &c. Qyod fi itaqve lymphae motus Bar= tholino occafionem dederit hepati exfeqvias fcribendi, feqvitur, motu hoc negato, etiam has fruftra fcriptas. Qyod cum fecerit Bilfius, non fine jure demonftrationem ejus flagitat Bartholinus, nee pro vecordi habendus, fi velit fe facilem praebere in admittenda hepatis [IV] RESPONSIO AD VINDICIAS HEPATIS REDIVIVI 73 refurrectione; modo ipfi probetur a Biljio, huraorem ilium, qvi in lacteis mefenterii continetur, per ilia deferri ad hepar. Qyid enim manifeftius? Qvod in lacteis continetur, in hepar non deferri, cum obfervaret Bartholinus, detexit nobis lymphatica, 8- hepati exfeqvias fcripjit. Qvod in lacteis continetur, deferri in hepar, ftatuit Bilfius, ejusqve demonfhationem promittit; ergo, fi vera haec, ruit lymphaticorum in= ventio, ruunt hepatis exfeqvix. Vidit hoc ipfe Clariff. Bartholinus, qvi Spicileg. p. 104., membro fecundo, qvod de rore agit, fubjun* git: In hoc cardine falus obfervationum nojlrarum volvitur. Cum itaqve res adeo perfpicua fit, qvid in verbis haeres, ex Bilfianam chyli interpretationem urges, qvafi vera rerum vocabula a Biljio effent exfpectanda? De motu humoris lactei agitur, non de nomine, qvem fi, fecundum promiffa, oftenderit Bilfius, affenfum obtinuit ex applaufum. Cum itaqve fatis pateat, qvae de Bartholino, de Te, de Biljio pro* pofui, licet ipfa adjungere verba conveniens difputationi brevitas non permiferit, fenfui tamen veftro verbisqve conformia effe: tranf* ibo caetera, & de fufpicionibus, qvas tibi formas, aeqvo Lectori judicium committam. Interea fi ulterius mea examinare placuerit, tantum temporis tibi indulgeas, rogo, ut cum verbis verborum confi* deres occafionem. Mallem tamen, ipfas res aggredi liberet, &, fi qvid vel experimentis, vel rationibus a me allatis deeffe videris, proferre: invenires enim me aeqve promptum ad argumentis tuis, fi ratione nitantur & experientia, cedendum, ac ad iifdem, ficubi praedicta defuerint, refiftendum. Vale. Lugduni Batav. Anno 1661, 28*18. Novembr. DE GLANDULIS OCULORUM NOVISQVE EARUNDEM VASIS OBSERVATIONES ANATOMICAL VIRIS CLARISSIMIS & EXCELLENTISSIMIS, D.SIMONI PAULLI, Medico Regio ex Praelato Aarhufienfi, D.GEORGIO HILARIO, Mathematico &. Litteratori, D.FRANCISCO de le BOE SYLVIO, Medicinae Practicae, DJOHANNIvanHORNE, Anatomiae &. Chirurgiae, D.OLAO BORRICHIO, Polyhiftori & Naturae Confulto, illi olim, his hodie in Regia Haf. Academia D.JACOBO GOLIO, Mathefeos ex Lingvae Arabicae in Alma Lugduno*Batava Acad. Profefforibus Celeberrimis, Praeceptoribus optime mentis, aetatem colendis. )V7E nova fe vobis hie fifiunt, Praeceptores, non eo no= mine pro novis venditantur, ac Ji jam primum effent producta. Antiqva funt, ipfis, qvi fe npo<5z\x\\ov)q 1 jactabant, Arcadibus, &■ univevfo adeo hominum gene= re antiqviora, utpote, qvx brutis ante conditum homi= nem, id qvod facta teftatur pagina, cveatis connata. Nee qvod nunqvam ante obfewata credam, ideo nova nuncupo; licet tot tamqve difevepantes de origine lacrymarum viisqve opiniones, qvot in mare Jlumina decurrunt, id tantum non demonftrare videantur. Exi= Jlimat Ingeniojiffimus Stevinus, fufpicantur alii, fuiffe feculum in fiu= diis aureum : nee dubito, qvin omnia Veterum fcripta nobis Ji adeffent, multa, qvx hodie nova & magno cum labore qvxfita miramur, fine fudore, fine fangvine inde licuijfet addifcere. Cum vero mihi nova fint, ut qvx nullius vel manus, vel vox, vel fcripta mihi detexerint, cum inclyta Nobiliffimx Lugdunenfis Academix Theatra Anatomica novis ea annumerauerint, fi rem, ut eft, verbis non exprimerem, levitatis effet non leve argumentum. Nee enim illorum ego fupercilium moror, qvi in aliorum labores involant, ipfi manum operi nunqvam admoventes; his enim, fi qvid aufi fuerint, veftrum, Celeberrimi Viri, applaufum, vefiram authoritatem oppono. Qya ego tutus xgide paucis ilia propo* nam, qvx pluribus diducere licuijfet, fi vel, qvx ex dictis fponte pro= fluunt, fufius evolvendo, tempus terere mens fuijfet, vel aliorum fcrinia compilando, lectoribus fafiidium, mihi Crifpini famam conciliare in= tenderem. Vos itaqve tenellum hunc fixtum vefiro finu excipite, &, qvo me hactenus profecuti eftis amore, amplexari pergite, Celeberrimi Viri, Difcipulum vobis addictif: Lugd. Batav. NIC. STENONIS Anno 1661. 6. Decembr. )VOD Mechanicos ufus docuit, forfan & in anima* libus facta obfervatio, ut ad motum faciliorem red= dendum res movendas humore unctuofo oblinerent; hoc in prima animalium fabrica Mechanicus omnium ingeniofiffimus qvam perfectiffime obfervavit. Vide* runt illi, fi movendum inter & fixum, fuper qvod motus fieri debet, tertium motu facilius intercedat, opus longe com* modius procedere, hinc, ut fuppofitis cylindris in aeqvora navem propellunt, fie ex, fuper qvem rota volvitur, polum liqvore pin* gviori inungentes gyrationem facilius expediunt. Sic &. alios motus, qvorum exemplis officinae hinc inde abundant, qviefcentem a mobili fuperficiem intercedente fubpingvi liqvore dividentes, minori cum moleftia perficiunt. In automatico autem animalium corpore artificiofius, imo divinius, haec omnia geruntur; ibi enim & humor, qvi fubminiftratur, ex, qvo fubminiftratur, modus longe majus artificium commonftrant. Partes qvippe ita difpofitae funt, ut in vicinia, velut in promptuario, reconditus liqvor pro majori minorive ufu parcior aut copiofior, nobis ne attendentibus qvidem, exprimatur, inde, ubi munere fuo functus, per alias vias alias ad partes iterum abducendus. Sic par* tium in ore motus accedente faliva promoventur; fie deglutitionem expreffus ab ipfa re deglutienda ex fubftratis tunicae glandulis unctuofus mador leviorem reddit. Eodem fine totus inteftinorum canalis interiori parte vifcida pituita eft obductus; nee aliam ob caufam in plerifqve aliis noftri corporis partibus moderata certi 82 DE GLANDULIS OCULORUM [VI humoris copia reperitur. Sed prae caeteris in oculis elegantiffime haec confpiciuntur; ibi enim &, qvae palpebrarum motui infervien* tem humorem afferunt, &, qvae eundem alio inde derivant, vafa peculiaria fe offerunt confideranda. Qvae cum nondum ita notata fciam (afferentia enim necdum defcripta puto, efferentia vero, licet principium habuerint omnibus manifeftum, continuationem tamen eorum magnis feculi hujus Anatomicis non innotuiffe, ex fcriptis eorundem patet), ftatui ea in praefens, ut in brutis variis, praefer* tim vitulis, a me obfervata, una cum glandulis defcribere. Glandulx autem interiorem palpebrarum fuperficiem humectantes binae funt, lacrymalis altera, altera Clariff. Whartono innominata dicta, ex conglomeratarum genere utraqve. Videtur qvippe con* glomeratarum hoc efle munus, ut peculiarem per lymphatica excre* toria excernendum humorem praeparent: qvod ante tantum in pan* create ex maxillarium inferiore obfervatum, jam vero in pluribus aliis manifeftum; ut praeter ilia, qvae de ftomaticis dicta, etiam aliae carnes ex glomis glandulofis compofitae demonftrant: qvales ex fub narium tunica turn interiore, turn pofteriore, ex fub tunica faucium, ex in epiglottidis fuperiori parte obfervantur, unde per ipfam car* tilaginem ad interiorem partem meatus reperiuntur confpicui; in qvibus lymphaticorum praefentiam facillime licet demonftrare. De glandulofa came, qvae in meatu aurium externo cartilaginem inter ex cutim fe offert, res non ita manifefta; cum ceruminum color aliam videatur originem agnofcere. Sed non mirum, flavum illis e glandulis fuccum excerni, cum etiam ex oris glandulis fimilis exprimatur; qvod in bubulo capite, ut ex ovillo, mihi perfpectum. Qyid qvod ex aqvofas excretiones fine ulla auditus laefione per aurem factas (qvarum Platerus meminit, qvi torn. 3. 1. 2. c. 7. refert, cuidam puellae ad menfuras aliqvot diu per vices citra ullam aliam laefionem inde profluxiffe) ex illis vitiatis originem ducere opinarer, cum alias per tympanum, auditu manente integro, vix potuiffet penetrare. Vel dicendum forte, obftructo, qvi ad nares pergit ab auribus, canali, iliac excernendum humorem hac tandem viam inveniile. Ut ut autem fit, praedictus glomeratarum ufus experientiam indies magis magisqve fentit faventem, qvod ex feqventia confirmant. Glandularum oculi altera, qvam innominatam vocant, in fuperiori exterioris anguli regione fita, magna &. fere rotunda eo in loco confpicitur; unde ad inferiorem orbitae partem inflexa in anguftam [V] OBSERVATIONES ANATOMICAL 83 veluti laciniam fenfim attenuatur. Pars ejus anterior per loborum, in qvos eleganter divifa eft, intervalla prodeuntibus ex ipfa glan* dula, qvae humorem ibi fecretum excernunt, vafis liberum exitum concedit; qvae inde interiorem intra palpebrarum tunicam antror* fum pergentia exiguis eandem foraminibus ad brevem a ciliis di* ftantiam pertundunt. In confpectum facile protrahuntur praedicto* rum Aluminum oftia, modo inverfam in exteriori angulo palpebram tantillum extenderis; mox enim ad medii pollicis ab exteriori limbo receffum, in ipfo angulo tria, infra qvatuor, fupra fex, interdum cv feptem patebunt: per qvae immiffa fine fectione feta facilem in ipfam ufqve glandulam tranfitum offendit. Haec fuperior mihi annus vafa detexit, cum 11. Novembr. eruti ex orbita ovilli oculi palpebram exterioribus tunicis nudatam candelae lumini exponerem, an pellu* cida effet, exploraturus: mox enim fplendentes lympha rivuli fuo fe indicio prodiderunt. Altera lacrymalis dicta, oblonga, in vitulo, & in cantho interiore leu majore recondita, praeter vafa fangvinea ex nervos, qvae illi cum reliqvis glandulis omnibus communia, etiam cartilagine prae* dita eft peculiari, &. duobus praeterea lympham evehentibus vafis donata. Cartilago duabus conftat partibus, altera tenuiore, qvae cui* libet vituli oculum infpicienti fe offert, lata, femirotunda, &. ad membranae naturam accedens, imo in membranam degenerans, cui limbus praetexitur craffior, &, qva oculum tangit, planus, averfa autem parte crenis paulo obtufioribus afper: altera crafjiore, qvae vere cartilaginea eft, &. alba, qva medio limbo continuatur, arctior, hinc in majorem amplitudinem fenfim expanfa ipfam glandulam inter cv oculum fertur, ubi iterum anguftior reddita circa medium glandulae definit. Excretoria vafa bina funt, qvae, intra glandulam orta, & ad cartilaginis latera affurgentia, ubi haec fuperiora verfus arctatur, cartilaginem inter c\ oculum fe aperiunt oftiis, non pa* pilla qvadam, fed folo hiatu dignofcendis ; qva ratione fe mihi primo obtulere, cum 19. Junii hujus anni in oculo eruendo occuparer. Puncta lacrymalia, ut in ove, vitulo, cane obfervavi, licet in utrovis oculo ad majorem angulum bina appareant, ubi tamen ad foramen lacrymale offi infculptum continuaveris, in unum truncum concurrere videbis; qvi, ubi canalem offeum fuperavit, ad interius reliqvi offis latus anteriora verfus productus, non procul ab extremo narium definit foramine uno qvidem, fed admodum manifefto. EXPLICATIO FIG UR ARUM Fig. I. exibens oculum finiftrum. vituli A. Glandula oculi fupe= riot, alias innomina= ta dicta. b. Angulus oculi major. c. Angulus oculi minor. d. d. d. Lobi, in qvos an* terior glandulx lim= bus eft divifus, per qvorum interftitia lymphatica, e. e. e., exeunt. Fig. II. A. Interior palbebrx fu* perficies. b. b. b. Glandula inno* minata, qvx una cum vafculis, c. c. c, per tenuem palpebrx tu* nicam tranfparet. d. d. d. Ofcula vaforum lacrymalium. Fig. III. A. Glandula lacrymalis in interiori angulo Jita. B. Cartilago ex ipfa glandula prodiens. b. b. b. Limbus cartilaginofus. c. c. Membrana. d. d. Oftia duo, ad utrumvis cartilaginis latus unum. Fig. IV. a. a. Punctorum lacrymalium ad extremas nares continuatio. b. b. Vas excretorium naribus proprium. [VI DE GLAND. OCUL. OBSERV. AN ATOM. 85 Licet autem praedicta vafa non nifi in brutis viderim, qvin tamen etiam homini fint conceffa, nullus dubito. Cum enim ex glandulae illi adfint fimiles, fimili in loco fitae, cum humor, qvi fub palpebris reperitur, non fit diverfus, oportet, etiam ejufdem generis vafa ibi admittantur. Sic ex puncta lacrymalia in homine, non minus qvam in brutis, confpicua fatis arguunt, continuationem eorundem etiam in homine inveniendam. Ex hifce glandulis earumqve vafis, qvi palpebras inter oculiqve globum obfervatur, humor procedens per lacrymalia puncta in nares defluit: qvi modo parcius accedens a paucis obfervatur, modo impetuofius profluens lacrymarum nomine venit; de cujus origine qvam varia a diverfis fuerint tradita, nemini ignotum; ut vel hoc argumentum ex illis unum effe poffit non poftremum, qvae, qvam parum ingenii, etiam fubtiliffimi, vis valeat, nifi fufficientia habuerit experimenta, demonftrant. Qyid enim non a variis hac in parte excogitatum? Fuere, qvi, lacrymarum materiam a parcius allabente humore diftingventes, diverfam utriqve originem affignarunt; fie e venis oculorum hunc exfudare, illas a cerebro provenire, Platerus ftatuit. Nee, qvi e cerebro lacrymas derivant, inter fe confentiunt: alii folo cerebro contenti de viis diffentiunt, dum hi anteriores choanae canales, illi nervos, ifti venas, &, nefcio qvas non alias, vias excogitarunt; qvidam vero praeter cerebrum alias in auxilium vocarunt partes; fie eas partim a cerebro per fecundum offis cu* neiformis foramen, partim a vertice capitis &. lateribus ad puncto* rum lacrymalium ductum confluere, Vejlingius putat. Qvi cerebro exclufo alia putarunt afferenda, nee hi inter fe confentiunt, qvidam enim ab oculorum nutrimento, alii a cryftallini humoris vitreiqve excrementis deducunt, Clariff. Schneiderus proxime ex arteriis, In* geniofiffimus Cartefius ex vaporibus, qvi ex oculis, qvam ulla alia parte, ob nervorum opticorum magnitudinem cv multitudinem par* varum arteriarum, copiofiores egrediuntur. Sed licet ex illis variae opiniones fatis ingeniofae magna proba* bilitate nifi videantur, experientia tamen longe alias vias demonftrat, ordinario Naturae modo magis convenientes. Ut enim, qvae omnibus partibus communia, univerfalibus organis peraguntur, fie, qvae fin* gulis debentur pecularia, peculiaribus locis praeparantur, & per vafa peculiaria excernuntur. Exiftimo itaqve, manifeftum fatis effe, ilium faltem humorem, qvi motui palpebrarum infervit, ex arteriofo fan* 86 DE GLANDULIS OCULORUM [V] gvine in glandulis fecretum per defcripta modo vafa adferri. Qyem ufum etiam alii illis attribuerunt, qvibus tamen vafa nondum fuere cognita. Clariff. enim Wharton. Adenogr. c. 26. ait: Non negandum, eafdem humiditates aliqvas, qvanqvam non ea copia, qva lacrymx ftillant, fuppeditare, licet idem brevi ante dixerit: Verum qvo modo glandulx illx humiditates has exfpuant, vel per qva? vafa eafdem ex= cipiant, nemo adhuc demonftravit. An autem ex lacrymae inde deducendae, dubium videtur, cum magni viri glandulas illas muneri huic non fatis idoneas judicarint. Non enim crediderunt, pofle ex tarn parvis glandulis tantam lacry* marum copiam prodire, ex feqveretur, etiam brutis attribuendas lacrymas, qvod multis abfurdum videtur. Sed, qvod primum fpectat, fi guttarum magnitudo cum tempore, qvo colliguntur, conferatur, nulla hie videbitur difficultas. Nee enim tempus adeo breve, qvin per plura vafa tantum humoris af* fluere poffit, qvantum ad guttam conftituendam reqviritur; nee, qvi ex oculis emanat, humor totus in glandulis antea fuit coacer* vatus: fufficit, ex eo, qvi fingulis pulfibus appellit, arteriofo fan* gvine celeriorem in glandulis fieri fecretionem, de qva mox pluribus. Qvod vero bruta attinet, cum ex illis hae glandulae &. haec adfint vafa, poterit £x in illis (qvod faepius obfervatur) copiofior ex an* gulis oculorum emanans humor lacrymarum fpeciem praebere, qvi non minus lacrymarum nomen meretur, qvam qvi ex oculis homi* num fine ullo animi motu ob folam materia? copiam, aut irritati* onem, organive vitium promanat. Exiftimo itaqve, lacrymas nihil effe nifi humorem, qvi oculo irrigando deftinatus eft, majori copia affluehtem, ideoqve, cum vafa in glandulis oculorum obfervata manifeftas ex propinqvas oftendant vias, ex occultis aliis aut remotis non deducendas. Non negaverim, ut ex oculis humor per ductum peculiarem in nares ftillat, licet ipfae fuis glandulofis carnibus non deftituantur, fie qvoqve ex ce* rebro fortaffis humorem fubfalfum per fingularia vafa in oculos derivari poffe; fed qvia fufpiciones pro veris venditare meum non eft, in medio haec relinqvens, qvae manifefta funt, proponam: cum ex iis omnia, qvae circa lacrymas obfervantur, phaenomena commode poffint explicari. Scilicet qvemadmodum cum ex fangvis bene fe habet, c\ organa rite funt difpofita, palpebrarum motum expeditiorem reddens hu* [V] OBSERVATIONS ANATOMICAL 87 mor naturali copia affluit, &. per convenientia foramina in nares derivatur, fie, fi vel internas, vel externas ob caufas alterutrum mutetur, etiam humoris mutabitur effluxus. Organa qvod attinet, poffunt &, qvae materiam fubminiftrant, vafa, &, qvae fecernunt, glandulae, qvaeqve fecretam educunt, excretoria vafa confiderari. Si fangvinem advehentia vafa ad revehentia naturalem in ampli* tudine proportionem non fervant, nee humoris fecernendi naturalis effluxus poterit exfpectari. Namqve ut fangvis, qvo facilius ex ar* teriis in venas tranfit, eo minus patitur immixta a fe fecerni, fecer* nendum enim una cum reliqvo per patentiores vias egreditur, nee per dicatos fero meatus nifi lente tranfeunt, qvae meatibus vicinae, partes, reliqvis libere praeterfluentibus: fie, qvo difficilius, eo copi* ofius per fimplices &. porofas capillarium intra glandulas exiften* tium tunicas exprimetur ferum; dum enim in anguftiis illis verfatur, nee eadem, qva affluit, per venas refluit libertate, qvicqvid per alias vias egredi aptum eft, ingreditur illis majori, ac naturaliter folet, celeritate, ut ita viarum anguftiam tranfitus celeritas compenfet. Atqve ita, licet nee plures, qvam naturaliter adfunt, aperiantur meatus; licet hi meatus non dilatentur (dilatati enim ita, ut una vice pluribus, qvam uni ferofae parti vel hanc conftituentibus minoribus, tranfitum praeberent, facile etiam craffiores fangvinis partes admit* terent), fola tamen partium per meatus illos tranfeuntium celeritas majori lacrymarum copiae producendae fufficit, a mutata vaforum in amplitudine proportione deducenda. Ut autem variatae proportionis hujus proxima habeatur caufa, videndum primo, in qva parte fiat mutatio, dein, qvid mutationem producat. Cum tria tantum materiae huic vehendae deftinata adhuc* dum innotuerint vafa, arteriae, venae cv lymphatica excretoria, ex* cretoria autem ejufmodi mutationi recipiendae inepta fint (conftricta enim minus ac ante reciperent, ampliata vero fecundum continuos fangvineis meatus alia, praeter ferum, tranfmirterent, fecundum re* liqvum autem ductum dilatata majorem folito humoris copiam non acciperent, nifi forte tractio qvaedam fingenda effet, qvae fuctione, vel alia qvavis ratione ferum attrahendo celeriorem contento mo* turn conciliaret, qvalia jam vix admittuntur): relinqvuntur venae cv arteriae, qvarum vel alterutri, vel utriqve infoliti qvid contingit. Cum autem tota mutatio in eo confiftat, qvod liberius affluat, qvam refluat, fangvis: vel amplicatae erunt arteriae, vel conftrictae 88 DE GLANDULIS OCULORUM [V] venae, vel utrumqve; cum autem vafis aliisye, qvae circulares habent fibras, conftrictio proprie contingat, dilatatio vero non nifi per ac* cidens, non in arteriis qvaerenda erit mutatio, fed in venis. Locus autem venarum, qvi hoc modo conftringi poterit, dum voluntariae fluunt lacrymae, non unus eft. Vel enim, qvae cordi vicina, pars, vel, qvae arteriis continuantur, extrema, vel media via huic mutationi obnoxia eft. In cordis vicinia ofiert fe mufculofa cavae portio, ideoqve animae imperio fine controverfia fubjecta, qvae, prout diverfimode movetur, fie duos primarios effectus edit, unde multa in animi motibus peculiaria procedunt. Scilicet vel utrumqve, fangvinem defcendentem puta, lympha plenum, dx adfeendentem, in iratis ad minimum ex omnium fententia bile mixtum, infolita inter fe proportione, folito parcius copiofiusve cordi ingerit; vel unius plus alterius minus immittit, atqve ita naturalem proportionem immutat; unde varia in diverfis animi motibus occurrentia fym* ptomata clare dx diftincte poffent deduci: qvae omnia latius exponere hujus loci non eft. Sed in lacrymarum profufione, licet non dubi* tern, hanc partem multum agere, dx non modo plus fangvinis cordi fuppeditare, qvod gemitus, rubor genarum, partium in facie inters dum tumor indicant, fed dx concurrentium proportionem mutare, qvod indicat copiofius in fangvine ferum, ideoqve, per refpondentes fibi meatus nifi excernatur, capitis dolores inducens, dx alia, qvae, fi lacrymae fupprimantur, obfervare licet, certo indicio naturalem humorum difpofitionem effe mutatam; cum tamen cor in omnes partes fangvinem aeqvaliter diftribuat, in multis vero flentibus praeter lacrymas vix qvicqvam obfervetur; cum faepe in motibus corporis, ira aliove fangvinis aeftu ab ambiente vel affumptis excitato, fan* gvini praeter folitum diftendantur arteriae, nee tamen lacrymae obo* riantur, nifi in magnis commotionibus, ubi tamen doloris qvoqve fenfus triftitiam excitans concurrit: reqviritur particularis locus dx oculorum glandulas, qvam alias partes, magis refpiciens. Sic dx medii vaforum ductus licet aliqvid pati videantur a mira partium faciei diftorfione, qvam in pueris, dx anteqvam profluunt, dx dum fluunt lacrymae, confpicimus, fi tamen intra glandulam nulla in vafis fieret mutatio, nee ulla feri a fangvine praeter folitum, in ilia tantum parte fieret fecretio. Reftant itaqve extrema venarum, intra ipfas oculorum glandulas utcunqve arteriis continuatarum, qvae dx con* trahi poflunt, dx anguftiora reddita proximam auctae fecretionis in [V] OBSERVATIONES AN ATOMIC JE 89 determinata parte caufam praebere, qva de re videri poffunt, qvae & fupra de mutata vaforum in amplitudine proportione diximus, ex in pofteriori De Glandulis Oris Difputatione, thef. 39., propofuimus. Expofita fie parte mota, facile eft moventem invenire. Cum enim animi motum, ut triftitiam, gaudium, interdum ex iram lacrymae feqvantur; cum prorumpentes lacrymas ad tempus fupprimere in noftra poteftate fit; cum eafdem pro lubitu fingere puellis, qvae, ut flerent, oculos erudiere, facillimum fit: manifeftum eft, illud, qvo mediante alios in corpore motus pro arbitrio anima excitat &. fiftit, fpiritus puta animales, etiam has in glandulas determinari, earumqve partes movere, maxime cum, per qvos ilia vis reliqvis partibus communicatur, nervi in glandulis adfint manifefti, ex fingularum in glandulis obfervatarum partium inductione nervorum cum venis confenfum rationi confentaneum oftendere liceret. Atqve fie vaforum fangvineorum in amplitudine mutatam pros portionem vidimus, qvae tamen fola non fufficit fecretioni lacry* marum augenda, nifi ex materia in fangvine fuerit lacrymis produ* cendis idonea, eademqve a fangvinearum partium amplexibus fuerit liberata. Hinc ratio, cur lacrymae interdum in longiori fletu fubfi* ftant, affumpto potu ftatim rediturae; hinc etiam manifeftum, cur juffae interdum non profluant, juxta illud Ovidii: Si lacrymx, nee enim veniunt in tempore femper, Deficiant — — — Eandem qvoqve ob caufam pueri puellaeqve ex fenes in ejufmodi animi motibus uberiores, ac mediae aetatis homines, lacrymas fun? dunt. Qyod autem in fummo moerore etiam fangvineae obfervatae fuerint lacrymae, valde noftrae favet fententiae, fi enim venae arteriis non anguftiores redditae liberum fangvini tranfitum conceffiffent, per tenellos ferofis partibus tantum accommodatos meatus fponte nunqvam exiiffet. Oportet itaqve, fangvinem impedito in venas re* fluxu qvofdam fero excernendo accommodatos meatus vel dilataffe, vel rupiffe, atqve fie viam inveniffe, qvam tenuit, ufqve dum, cef* fante fpirituum animalium in praedictas partes determinatione, per folitam viam liberius remeare licuerit. Atqve ab hac mihi caufa procedere videntur, qvas voluntarias appellant lacrymas, qvo etiam illae, qvae in magno movendi conatu 90 DE GLAND. OCUL. OBSERV. AN ATOM. [V] praeter voluntatem erumpunt, nee non a fumis ex halitibus elici* untur mordacibus, ex parte reducendae. De caeteris, qvae fpontanearum nomen obtinuere, res facilis. Vel enim caufas habent in oculos incurrentes, ut fi cum excretoriis vafis afficiantur glandulae, aut humoris naturali copia affluentis per elices in nares tranfitus impediatur; vel peccanti in fangvine fero debentur: cujus partes fi ob elementorum proportionem cum lacrymis, qvam cum fudore, urina, fucco pancreatico, faliva affinitatem habuerint majorem, non mirum, per convenientes partium fuarum figuris meatus in oculorum glandulis excerni, unde varia, qva lacrymas, in morbis occurrentia fymptomata commode liceret explicare. Sic refert Clariff. Bartholinus hyftericae cujufdam paroxyfmos, non nifi fuborto ubere lacrymarum fluxu, fponte folutos. Qyo in cafu exiftimarem, qvi fangvinearum partium vinculis arctius irretitus humor varia, qva motum, qva fenfum aliasqve functiones, in toto corpore fymptomata excitabat, tandem vel medicamentorum vi, vel inteftino heterogenearum in fangvine partium motu ab aliorum amplexibus iiberatum, qvod lacrymis, qvam reliqvis humoribus, fimilior effet, per illarum vias exitum inveniffe. Cur autem ad earum propius qvam aliorum humorum naturam in ilia femina accefferit, licet feminarum ad lacrymandum proclivitas aliqvid eo conferre potuiffet, cum tamen in aliis idem non obfervetur, non, nifi examinata aegrae natura, certo determinare licet. Poffem alia de ophthalmia ejusqve curatione addere, fed cum, viis jam detectis, ilia fponte pateant, qvae verum glandularum oculi ufum, verosqve la* crymarum fontes fpectant, hifce propofuiffe contentus, fufiorem variorum, qvae eo reduci poffent, deductionem eo ufqve ditteram, donee integram glandularum hiftoriam pertexere Numen permiferit, ubi fimul oftendam, qva ratione glandulae cuti undiqve fubftratae fudorem producant. DE NARIUM VASIS NTE autem, qvam a tabula manum removeam, non poflum, qvin, qvae mihi lacrymarum collicias, ef* fractis narium offibus, penitius inveftigare conanti in ipfis fe naribus obtulerunt, prioribus appendicis inftar adnectam, cum idem plane, qvod oculorum theca, artificium prae fe ferant. Nares fuccingens tunica cum non modo in demortuis, turn ho* minibus, turn brutis, humida reperiatur, fed &. in vivis perpetuo qvodam madore percipiatur irrigata, nee tamen perpetuus e naribus aqvofi humoris profluat rivus; neceffe eft, vias dari turn in nares humorem ilium deponentes, turn eo in loco depofitum alia inde via abducentes. In hanc me non de naribus modo, fed & pericardio aliisqve partibus, opinionem jam turn pertraxerat oculorum ex oris fabrica: fed cum argumenta Anatomica, praeter analogiam, etiam aurov}){av reqvirant, fufpicionibus tantum annumerandam duxi, eo qvod utrumqve hujus propofitionis membrum fuos videbatur exfpectare adverfarios. Priores enim vias in dubium vocarent, qvi ad odores bene percipiendos ficcas, non unctas, reqvirunt nares, ex magni Hippocratis verba vel dubitantibus opponunt, qvae Libv. de Cam. leguntur: Kai ftxav uev £np& r\ xct xoiAa xf\q ptvoc;, oojadcJ^ai tcov ^rporepcov ambq (6 ^yxecpaAoc;) ecouTou ctxpw (3eCT£p6c; donv; &. mox: oxorav be uypavO'ecocfiv ai pTveq, oi) buvctTat 6<5cppat'vecj8'at. Qvod fi itaqve odoratus organi ficcita* tern reqvireret, nulla hie admittenda vafa, cum non modo nulli effent ufui, fed dx ipfum impedirent fenfum. Pofteriores vero ab 94 DE NARIUM VASIS IVI] imminente faucibus hiatu diverfos non facile admitterent, qvi na* rium humorem, fi qvis effet, aut a praetervecto aere exficcari poffe contendunt, aut per patentes vias in fauces rejici; atqve ita, licet illis humidas canum, qvorum odora vis nulli non cantata, nares, 6, ipfam humoris neceffitatem ad halituoforum corporum faciliorem in poros ad nervorum extrema tranfitum objicere potuiffem, licet his turn ilium & in homine, &. in brutis, narium fitum, qvi non patitur, humorem in fauces relabi, turn illam humoris naturam opponerem, ut non poffit ab aere folo intra pectus pulfo, vel ab eodem una cum calidis fuliginibus e pulmonibus rejecto in tenues auras diffipari, id qvod ipfe Vulcanus, fi ad partes vocetur, demon* ftrat: dubius nihilominus haerebam, ufqve dum praeter aqvx duc= turn jam ante cognitum, ex praeter glandulofas carnes tunicx SchneU dero pituitarix appellatae, etiam punctovum lacrymalium in nares ufqve continuationem, aliumqve naribus peculiarem ductum, omnia nares humectantia vafa, cv fimul angujium qvafi fretum, per qvod con* tentus in naribus humor in palatum tranfmittatur, obfervarem ; turn enim patebat, nifi Hippocratis verba de immoderato humore effent intelligenda, ipfi experientiae bellum effe indicendum. De primo nares irrigante canali, f. aqvx ductu, humorem, qvo aurium cavernae maduerunt, eo deferrente, cum a variis Celeberri* mis Viris fit defcriptus, nihil hoc loco addam, fed reliqvis annu* meraffe contentus ad feqventes pergam. Secundum, per qvem ab oculis in nares derivatur humor, qvod attinet, cum in antecedentibus p. 84. fuerit defcriptus, nee ille diu nos morabitur. ClariiT. Vejlingius exiftimat, definere ilium intra pal* pebrarum tunicas, cui fuum etiam calculum Celeb. Schneiderus ad* dit, qvi De Catarrhis, 1. 3. c. 9 p. 348. ait: Ante hunc authorem (fc. Vefling.) hxc & hujufmodi alia pervidimus, ac multis locis do* cuimus, hxc foramina non ulterius ferri. Nam palpebva ex duabus conftat membranis, inter has ufqve ad orbitx Jinem excurrit hoc fo= raminis genus, & inibi dejinit. Sed in nares ufqve pertingere, non in brutis modo, fed &. in homine, una cum ClariiT. D. van Home, jam fecundo obfervavi. Mirum fane, exercitatiffimum Virum Fabricium ab Aqvapendente , qvi nervofum in ipfo offis lacrymalis meatu obfervavit ductum, eundem punctis lacrymalibus continuum non perfpexiffe. Sic enim de ocul. part. I.e. 13. refert: Propter qvam caufam Natura fapientiffima duplicem viam ad lacrymas expurgandas [VI] DE NARIUM VASIS 95 paravit. Una eft per oculovum utrofqve angulos, alia per nares. Etenim in utraqve extremitate tarforum, fuperna fcilicet &. inferna, bina in utroqve angulo foraminula apparent, tarn exigua atqve angufta, ut vix in viventium corporibus adfpectabilia fint, in cadaveribus autem omnino fenfum effugiant: per qvx lacrymx, cum ejfunduntur, exeunt, potif Jimum autem per internum angulum, quo ut decliviore utitur Natura ad lacrymarum effluxum. Alia autem atqve adhuc patentior via nares funt, in qvarum fummitate ad internum angulum foramina in offe in= fculpuntur tarn magna, ut qvivis ea admiretur: qvx Ji attente intuearis, infignes qvidam canales tibi videbuntur eo loci ad hunc ufum excavati, ut lacrymx per nares expurgentur, qvin etiam ductum qvendam ner= vofum ab oculis in ejufmodi foramina ingredi videbis, qvaji accommo= datum canalem ad lacrymas in nares derivandas. Mirum, inqvam, Virum Celeberrimum, una cum aliis ejufdem fententiae patronis ea dividere, qvae Natura voluit efTe conjuncta. Tertio loco, qvae in ipfa narium tunica oriuntur, vafa exami* nanda, qvae duum generum funt: breviora alia, ex vix nifi per ex* preffum humorem, cujus guttae fenfim prodeuntes vaforum oftia produnt, confpicua; alia longiora, qvae veri canalis nomen merentur. Breviora vafcula ilium effundunt humorem, qvem in membrana pituitaria anteriore obfervavit Schneiderus. Cui Celeberrimo Viro adftipulari neqveo, dum membranae munus illud totum adfcribit, nulla glandularum facta mentione: cum tamen fub ipfa membrana vaforum, qvae copiofa ibi reperiuntur, extremis affufae fint glandu* lofae portiones in parte narium anteriore minores, qvo vero pofteriora verfus magis recefferis, majores, unde exigua qvaedam excretoria oriunda fecretum ex arteriofo fangvine humorem emittunt. Longiora vero in homine qvidem nondum vidi, in ovibus tamen canibusqve non raro notavi. Sunt autem bina, in utravis narium cavitate unum, ubi ex originem agnofcit &. finem. In illis enim, qvae fub narium tunica in ovibus difperfae latent, glandulis radices plurimae fupra molarium regionem obfervantur eleganti ordine dif* pofitae, e qvibus unum in truncum coeuntibus ductus exfurgit, qvi, ubi fub nervofo canali dorfum verfus adfcenderit, in anteriora inde reflexus dorfum inter & continuum punctis lacrymalibus vafculum progreditur, donee circa extrema fere narium, qvo loco fupra re* liqvam planitiem cartilago exfurgit, in finum intra cartilaginofam alarum protuberantiam confpicuum fe exonerat. Non difficulter in 96 DE NARIUM VASIS [VI] adfpectum producitur, five oftia qvaeras, five fontes; hos enim cum ipfo progreffu ut oculis fubjicias, effringenda tibi narium offa, in* tegra manente, qva fuccinguntur, tunica, dx fimul fuo fe fplendore per tunicae exteriora decurrens lymphaticum prodet; qvod fi furfum continuaveris, elegantem ramulorum fobolem radicum munere fun* gentem deprehendes. Sin oftium defideras, primo circa globum nafi refecanda eft alarum alterutra, hinc fupra cartilaginofam ex* crefcentiam (in cujus inferiori loco oftium, per qvod oculi fe ex* onerant, hiat) eadem ala dividenda, illico enim qvendam qvafi fulcum videbis, brevem ilium, fed immiffum ftylum in ipfum ufqve vafculum deducentem. Saepius in ovibus totam extra ductum pro* currentem foffam nigredo, qva, ut haec, fie & omnia fere lympha* ticorum excretiorum turn in buccis, turn fub lingva, oftia in iifdem non raro tincta obfervantur, vel obiter infpicientibus velut intento digito demonftrat. In canibus oftium ejus non in ipfo cartilaginis dorfo, fed inferiori loco fe exonerat, nee ipfe canalis eandem a narium culmine in progreffu fuo diftantiam fervat. Vifis, qvibus nares irrigantur, vafis, infpiciendae funt viae, qvibus idem, ubi munere fuo functus eft, humor, alio ablegatur. Sunt au* tern ex illo genere, qvae hie examinari merentur, binae, in utravis parte una. Nee enim hiantia nafi oftia, qvae reciproco aeris motui patent, hue referenda, cum foras fpectantia huic muneri deftinata non effe integer vitas ftatus, qvo nunqvam qvicqvam hac excernitur, demonftret; qvae vero introrfum vergentia faucibus imminent, prae* terqvam qvod magnitudo &. ufus omnibus nota reddiderit, ut adeoqve fupervacuum fit ea hie defcribere, etiam ipfe fitus huic muneri non fufficientes manifefte convincat. A naribus itaqve in palatum qvi patet, tranfitus brevis admodum eft, nee canalis, fed foraminis nomine dignandus. Locum fi qvaeris, in extremo nalo offendes, ubi fupra tertii maxillae offis fupercilium exfurgens carti* lago allabentem humorem, ne extrorfum profluat, remoratur. Hoc intra repagulum in homine ad vomeris latera proxime invenies foramen rotundum, qvod licet fuperiori ambitu fatis fit amplum, mox tamen arctatur adeo, ut ne fetae qvidem in palatum tranfitum concedat. Qvod fi palati coelum infpexeris, in homine qvidem, ut ex in canibus, ad anteriorum dentium radicem tuberculum exfurgere videbis, ad cujus latera, modo tantillum prefferis tunicam, gutta utrinqve una profiliens oris cum naribus commercium manifeftabit. [VI] DE NARIUM VASIS 97 In bubulo autem, ut &. ovillo, qvibus in fuperiori oris parte primores denegati, eundem meatum cordis figura qvaerentibus indicabit, latera enim cordis illius immiffo ftylo in nares viam aperient. Obfervan* dum autem, in duobus hifce fubjectis fitu variare illam cordis fi* guram, ex mucronem ejus in ovibus fauces refpicere, cum in bubus eo bafis dirigatur. Sed nee in diverfis craniis eadem eft meatus hujus conformatio; in homine enim, qvae ab intermedio vomere in narium cavo divifa confpiciuntur foramina ex parva, fi maxillam invertas, infra dentes in unum confluxiffe deprehendes. In brutis autem manent divifa, nee rotunda funt, fed in oblongas rimas extenfa. Vifis itaqve, qvibus nares accipiunt humorem, acceptumqve ite* rum dimittunt, viis, ulterius pergendum effet, ex inqvirendum, turn in humoris ipfius naturam, turn in vafa materiam ejus advehentia, turn in modum, qvo a fangvinearum partium amplexu liberetur. Sed cum in praecedentibus haec utcunqve fint examinata, fpecialior autem ex ipfius humoris ex modi fecretionis cognitio plura reqvirat experimenta, in aliud ea tempus differam, donee ex facultates meae cv tempus varia, qvae mente concepi, re ipfa permiferint experiri. Ex illis, qvae turn hie, turn fuperius dicta, manifefte patet, qvam ftudiofe id egerit ingeniofiffimus animalium Conditor, ne qvae for* des regiam fedem, caput puta, inqvinarent. Humectandi erant cum aurium cavitate oculi, irrigandae nares, os faucesqve unctuofo hu* more oblinendae: nihilominus nee oculi, nee nares, nee fauces, fi naturae convenienter vixeris, qvicqvam excernent. Qyid enim la* crymae, nifi moti animi figna? qvid mucus narium, qvid oris fpu* turn, nifi vitae a fanitatis legibus deficientis fymbola? Kpareei yap Tct Gm'a touc; ttovouc;. Ubi munus fuum implevit ille humor, ex auribus per aqvaeductum, ex oculis per collicias in nares deri* vatur, unde partim per ingentes hiatus in fauces, partim per angu* ftum fretum in oris cavitatem dimittitur; ex hinc per cefophagum in ventriculum defcendens, ex in vafa fangvinea per chyli lymphaeqve ductus viam affectans, peculiarem fuo modo circuitum abfolvit. SUDORUM ORIGO EX GLANDULIS. DE INSERTIONE aVALVULA LACTEI THORACICI 6, LYMPHATICORUM THOAUE BARTHOLINO HAFNIAM lV.ffi a longo tempore tibi deftinaveram, Celeberr. Vir, vix tandem elapfo femeftri, & qvod excurrit, fpatio, tuo fe fiftunt examinanda judicio. Decreve* ram qvidem a Difputatione illico de novo curare imprimenda, ut, qvae mutilata turn temporis propo* fueram, integra tranfmitterem : fed mox brevi per illuftriores Belgii urbes excurfione avocatus, hinc variis hinc inde advolantibus impedimentis diftractus, tandem ipfis fectionibus, dum nova qvaelibet obfervatio effet inftrumentum feqventis, detentus, non potui rem ad umbilicum perducere; & nifi angufta domi res me retraxifTet, in glandularum examine ulterius perrexiflem, qvippe defiderans omnium vafa perluftrare, &. fimul lymphae in variis cor* poris noftri cavitatibus confpicuae vias inveftigare. Non enim du* bito, qvin omnium, qvas Clar. Sylvius conglomeratas nominat, glan* dularum munus lit, per peculiaria vafa vicinas humectare regiones. Sed c\ parum abeft, qvin credam, omnes humores aqveos in variis cavitatibus occurrentes iifdem a glandulis derivandos. Qyid qvod ex fudor non aliam videatur originem agnofcere? Aliqvot enim in Nofocomio vicibus vidi in macilentis ex diuturna morbi tyrannide omnino exhauftis cuti proxime fubftratas innumeras exiles glan* dulas turn in abdomine, turn aliis in locis per fubtiliflimas fibrillas, qvae pro valis videntur habendae, cuti connexas. Et paucis abhinc diebus cum Clariffimus Sylvius, qvi hoc trimeltri praxin exercendo docet, facultatem mihi daret, in fubjecto, cujus ille iam turn partes 102 SUDORUM ORIGO EX GLANDULIS [VII] fuo inftituto infervientes demonftraverat, pro lubitu qvaevis exami* nandi, vidi, diffecta in cruribus admodum tumidis cute, glandulas, qvae alias vix confpici folent, adeo egregie confpicuas, ut genus earum, qvo nempe referenda;, minime latere poffet. Haec itaqve & alia glandularum praecipue ex pluribus fruftulis compofitarum natu* ram fpectantia abfolviffem lubens, adjunctis etiam illis, qvae, haec dum ago, aliis in partibus una fe mihi obtulerunt, non qvidem nova, a multis tamen hodie in dubium vocata, fi usinPa= amplior ita ex manifeftior. In diverfis varius apparet, qvod vituli, ovis, canis, cuniculi diducta inter fe conferentibus ora, dignofcere integrum. Ejufdem in avibus vice fungitur pofterius palatum dividens rima. VI. Epiglottidis cartilaginem permeantes canaliculi; qvi, a carunculis Vafa epU epiglottidi incumbentibus orti, per cartilaginem tranfmiffum humo* glottidis. rem averfa ejus parte, qvae laryngi imminet, evacuant. Non his annumerabo, qvae in variarum avium oefophago &. in* gluvie confpecta mihi vafa, cum ex illo perceperim, Clariffimo cuidam Viro, Anatomes qvondam cultori dexterrimo, in gallina id generis ante qvaedam obfervata. In cygno cefophagi tunica innu* meris perfperfa punctulis totidem inde manantis aqvei humoris protrudebat guttas, ingluvies vero craffior &. afpera non multo pauci* ores albi ex vifcidi fucci indicabat fontes. Sed his miffis ad nares tanqvam fecundam contignationem adfeendam. VII. Qyx narium tunicam irrigant vafcula; cujus humorem non Vas narU ab oftiis arteriarum (natura has pro arbitrio jam claudente jam reie* um- rante) emitti, tunicae ab offe feparatae & ab inverfo latere infpectae docet examen. VIII. Vas illud narium, qvod non nifi in ovibus mihi hactenus no- Vas narh tatum; cujus radices in pofteriori narium parte ortae in ramum ftyli um 0Vli>us capacem confluunt per narium latera verfus anteriora progredientem. pe 186 DE MUSCULIS & GLANDULIS [XV] Viae a paU pebris in nares. Vafa paU pebrarum. Vafa rajas fuperfici= em exterio= rem lubri- cantia. IX. Collicix, f punctorum lacrymalium in unum utroqve in latere ductum concuvfus, humovem palpebrarum in narium cava derivantes. Non exigua hie in diverfis animalibus differentia. In homine ipfis ciliorum apicibus infculpta foramina breves demittunt canaliculos, nee demonftratu faciles, nifi caute diffractis narium offibus tunicas relinqvantur integral, mox enim, ubi offa penetraverint (qvo ufqve tenui feparantur membrana), in finum ampliati narium continuantur tunicae. In ove, lepore, vitulo, cuniculo non in ipfis ciliis, fed in* terius paulo eadem reperiuntur oftia, qvae profundius in avibus qvaerenda, ubi, qvam in ullo alio genere longe majora, receptum majorem ftylum per palati rimam emittunt; brevis hie admodum, qvae foramina diftingvit, membrana. X. Vafa palpebrarum, feu lacrymalia; qvae numero plura fontium habita ratione ad duo reducuntur genera: qvorum alia exteriora, externo oculi angulo accumbentia, glandulae eundem angulum occu* panti debentur multis dictae innominatae; interiora alia, qvam com* muniter lacrymalem appellant, glandulam pro fonte agnofcunt; qvibus, qva nictent, data membrana, per eandem incedentium vaf* culorum interius hiantia continent oftia etiam in avibus ftylum non excludentia. XI. Liceat his adjungere, qvae in raja mihi confpecta, occafionem fubminiftrante Clariffimo Praeceptore Simone Paulli. Multis ilia ni* gris variegata maculis totidem foraminibus pertufa tegitur cute, unde vifcidi humoris prodeunt guttae, fi foraminibus continuas prelTeris ftrias, in qvas per eadem oftia protrufa libere permeat feta. Et haec qvidem, qvae nemini notata puto, vafa funt, qvorum multa fine lectione confpicua fi notaffet Galenus, fuam De Ufu Par* Hum 1. 2. ingeminaffet interrogationem, ubi legitur: Num igitur mi= raris, aut non credis, aliqvid eorum, qvx funt obfeuriora in Anatome, ignoratum fuijfe ab eis, qvibus ne ea qvidem, qvx ante Anatomen appa= rent, nofcuntur? Sed cui haec magni Anatomici probabitur exproba* tio? Multa fine lectione confpicienda ignoravit Galenus, nee dubito, qvin id generis alia multa fuperfint, qvae, qvod nimis forte obvia, no* ftram impetrare neqveunt attentionem. Bene qvidem ab illo dictum, fi mortalium neminem excepiflet; cum vero praedecefloribus tantum fuis ea objecerit, parum aeqvus aliorum fuifle videtur cenfor, nee ad anguftiffimos humanae cognitionis limites hoc in loco refpexifle. [XV] OBSERVATIONUM SPECIMEN 187 Vaforum ante obfervatorum illuftrationi ferviunt feqventia. I. Lymphatica illuftrat turn glandularum conglobatarum generalis fabrica, turn lymphaticorum vera in venas infertio. Conglobatis id omnibus, qvas hactenus obfervare datum, familiare, Congloba- ut arterias praeter venasqve ex nervos binas lymphaticorum in fe tarum fa* contineant fpecies, advehentem, puta, alteram, alteram evehentem; brica. qvo a conglomeratis differunt, qvibus fola evehentia contigere. Ipfa vaforum radicibus undiqve affufa fubftantia earn obtinuit confor* mationem, ut nulli, qvam renum corpori, commodius poffit corns parari, cui qvaedam illarum, qva figuram, dico, non colorem, fimil* limae. Exterius enim globofae, interius non qvidem pelvi qvadam excavatae funt, feparationem tamen rite 11 aggreffus fueris, inter protuberantia undiqve labra rimam invenies, qva egrediuntur una cum membrana qvadam lymphatici evehentis radices. In exteriori fuperficie, 11 caute cultri aciem direxeris, videbis ex diverfis adve* hentibus lymphaticis numero multis prodeuntes ramos ipfam fur* culorum numerofa propagine fubftantiam ingredi; qvod parotis conglobata in ovibus ex vitulis eleganti fchemate teftatur. Harum glandularum refpectu triplex lymphaticorum contenta fua in fan* gvinem reducentium exfurgit differentia; aliae enim a primis fon* tibus, qvalefcunqve illi tandem inveniendi, in glandularum fpar* guntur fuperficiem; qvaedam e cavo unius glandulae in alterius gibbum pergunt; reliqvae ab harum glandularum cavo ad cavam ufqve exporriguntur. Lymphaticorum vera in venas infertio, ut multorum frultrata inqvi* Lymphatic fitionem, ita nemini, qvam Nobiliffimo Biljic, magis impofuit. Pri* corum in mus ille veram hujus fectionis videtur detexiffe methodum, fed ex v*nas m= primus fe inde paffus ad abfurdas deduci opiniones. Alibi haec •* plenius, ubi ex errorum ejus manifefta dabitur caufa, jam ante in meis Obfervationibus indicata, ex infertionis varietas variis in figuris patebit. Hie paucis dixiffe fufficiat, in venas circa axillaris jugula* risqve confinium utroque in latere lymphaticorum demonftrandam infertionem, ex qvidem in dextro eorum, qvae a dextris partibus anterioribus in brutis, ut e dextro pleurae facculo, pede anteriori dextro ex dextro capitis latere confluunt, in finiftro vero praeter dictis analoga finiftri lateris vafa, etiam ipfius, qvod inferiora omnia recipit, ex fuperioribus ante infertionem fociatur, thoracici. Commu* nis omnium in finiftro latere confluentium concurfus nee recepta* 188 DE MUSCULIS & GLANDULIS [XV] culum conficit, nee valvulis donatus eft, nee, qvod Biljius nobis perfvadere voluit, per unicum fua contenta in cavam exonerat oftium. Nunqvam enim duobus pauciora, faepe vero tria, interdum &. qvatuor deprehendi, &, ut certi effent fpectatores, vere hac via in fangvinem infundi ex chylum ex lympham, vafa ita concurrentia fimplici tantum preffione modo lympha, modo lacte replevi, inde ex varia agitatione fangvini eo viam patefeci fine ulla vel vaforum vel valvularum laefione. Sed haec paucis ante tacta, fufius alio in loco tractabuntur, una cum modis valvulas lymphaticorum dete* gendi. Annulus vel labyrinthus Bilfianus nee in omnibus fubjectis confpiciendus, nee, ubi adeft, eadem Temper facie confpicitur, vel qvicqvam eft nifi lymphatici a permeantibus arteriis venisve aut nervis facta divaricatio. Ductus II. Ductui Wirtzungiano illuftrando fervit in avibus facta obferva* Wirtzun? tio, qvae hepatis qvoqve ufum reddit clariorem. In variis enim, gianus. qVas aperire licuit, avium ipeciebus geminum vidi ductum pancre* aticum, ductui bilario itidem gemino (qvorum alter a veficula fellis hepati non accumbente, ab hepate alter) occurrentem, qvorum qva* tuor vaforum infertio tribus variat modis, vel enim in unum omnia confluunt oftium, vel cum luo qvilibet pancreaticus bilario com* mune oftium fubintrat, ita ut duobus tantum foraminibus pervium fit inteftinum, vel fuus cuilibet ductui conceffus exitus id efficit, ut qvatuor diverfae fecundum eandem rectam ftylo pateant in inteftina viae. Nuper in Africana gallina vidi hepaticum ductum, ubi hepate exierat, fimplicem, in progreffu bifidum duobus inteftinum adire canaliculis, qvod adeoqve tribus bilem e vafculis recipiebat. Non exiguam haec, ut puto, lucem afferunt utriufqve humoris ex explicandae utilitati ex occurfui mutuo confirmando, qvem ex illu* ftrat pancreatici ductus in ipfum bilarium, anteqvam ad inteftinum pervenerit, in media via infertio ovibus peculiaris, qvam etiam poft a diligentiffimo Highmoro jamdudum defcriptam ex delineatam video. Ductus III. De Whavtoniano unum monebo, qvod ex me fefellerat, meas Whartoni- cum ederem Obfervationes : fcribit, ab appofita (conglomeratae con* anus. globata) glandula in ipfam maxillarem inferiorem (conglomeratam) vafculum pergere, qvod ex ego initio ibi fubfiftere credidi, Whartoni fidens obfervationi, fed ulterius poftmodo fectionem continuando obfervavi, inter dictae maxillaris glomeramina ad conglobatam ali* am penetrare, adeoqve lymphaticis Bartholinianis annumerandum. [XV] OBSERVATIONUM SPECIMEN 189 Ex hifce, fimilibusqve &. aliorum & noftris obfervationibus fe* qventia partim corporis oculis fubjecit experientia, partim mentis oculis ratio perfpexit. I. Lymphaticis omnibus cum glandulis commercium effe; dicerem Lymphae omnium lymphaticorum primam fcaturiginem glandulas falutandas, oviS° ,mr fed cum prima lymphaticorum Bartholinianorum origo, qvo plures me iata admittit explicandi modos probabiles, eo fit incertior, id faltem verum manet, nullum in corpore vifum lymphaticum, qvod non vel oriatur a glandula, vel in glandulam inferatur. II. Lymphatica omnia conglomeratis continua fuum in certas ca* vitates effundere contentum, ut oculos, aures, nares, os, oefophagum, laryngem, ingluviem avium, &c. III. Qvae conglobatis annectuntur, fua in cavam revehere con* tenta, vel immediate, vel mediantibus aliis conglobatis, &. qvidem non modo circa axillarem finiftram, cui qvidem totus communiter fe jungit thoracicus, fed & in axillarem dextram, qvo loco vellem, monftraret nobis Biljius roris fui ad dextra capitis lymphatica diftributionem, feu lymphaticorum fuperiorum dextri lateris cum thoracico concurfum. IV. Ipfas adeoqve glandulas omnes vifcera effe, per qvae fuas lymphatica difpergunt radices. Et haec qvidem omnia pro veris habenda fvadet ratio, qvia fen* fuum ea probat teftimonio, probabilium vero tantum numero in* ferendas judicat feqventes, qvas ex inductione, licet non omnibus numeris abfoluta, elicit propofitiones. a. Qyocunqve corporis animalis loco aqvofus qvidam naturaliter reperitur humor ejus fuperficiem oblinens, eandem fuperficiem lym* phaticorum pertufam oftiis a conglomerata glandula oriundorum; unde colligere liceret, 1. eandem aqvx pericardii effe originem, qvam Amici Clariffimi de thymo obfervatio confirmare videtur; 2. nee fudorum diverfos inde fontes, de qvibus in fudoris examine latius, ubi omnium, qvae cutem conftituere poffunt, partium inductione, ex fudoris cum aliorum humorum comparatione, caufarumqve hu* mores hofce moventium examine probare licebit, ex hactenus ob* fervatis de cute probabilius nihil did, qvam effe earn fubftantiam glandulofam, hoc uno a reliqvis diverfam, qvod praeter vaforum capillaria etiam pilorum radices per corpus fuum habeat difperfas. Confirmant me hie rajarum cutem perforantia vafa, unde veram 190 DE MUSCULIS & GLANDULIS [XV] lubricitatis pifcium judico exfpectandam caufam. Qyos fine cuticula generatos narrant, eorum ferum credo fuiffe vifcidius, qvam qvod ad primum aeris contactum evanefceret, vel eorum cutem perpetuo fudore maduiffe, ob humoris in corpore copiam, viarumve magni* tudinem, aut impeditum feri per alias glandulas tranfitum. 3. In ventriculis cerebri humorem fimili ratione fecerni, cui favere videtur ab aliis ante notata in plexu choroide glandulofa fubftantia. 4. Qyi thoracis abdominisqve partes oblinit, humorem originis qvandam habere analogiam. 5. Humoris, unde &■ fit &■ nutritur foetus, non diffimilia qvaerenda cribra. Qyibus enim cotyledones adfunt, ani* malia dx adhaerentes utero fpongiofas carnes c\ ex harum cavernulis extrahendas facile fine fangvine chorii radices exhibent. In fele, ubi latus ovum cingit annulus, cum annulo ovum ab utero fine fan* gvinis effufione feparavi, eratqve annuli fubftantia vere glandulofa, qvemadmodum & ipfam uteri, cui adhaerebat, fuperficiem afperam reddebant eminentiae glandulofae. Sunt c\ in amnio qvorundam in* terius alba, qvae fangvinea vafa recipiunt, corpufcula. Sed haec, ut dixi, fufpicionum cohortibus inferenda. 3. Conglomeratarum lympham, poftqvam in certas e vafis effufa cavitates, non ibi fubfiftere, fed alio per alias vias intra corpus ablegari; fie ex auribus ex oculis in nares, e naribus in os, ex ore in oefophagum, cxc. Hinc patet, qvaerendas etiam vias, per qvas evacuatur pericardium, cerebrum, thorax, abdomen; liceret etiam de oculi aqveo fimilia fufpicari. Inter qvaerenda vias cerebri hu* morem excernentes collocavi; necdum enim res haec determinata, licet apud Medicos nihil audiatur freqventius, qvam a capite fub* jectas in partes deftillare humores. Adefle in cerebro, &. qvidem femper, humores, freqvens cerebri fvadet fectio, qva vero iidem via emittantur, inventu non adeo facile. In eqvo cum pituitariam glan* dulam a plexibus innumeris, qvibus implexa, liberarem, vidi, me ftylo patulam in venas habere viam, ut adeoqve in fufpicionem devenerim, per pituitariam glandulam tranfcolatum cerebri humo* rem venis fine interventu aliorum vaforum recipi, fed inde per alias inqvifitiones non licuit eodem fine fimilem repetere fectionem. Lymphx Ab oftiis lymphatica continuavimus ad fontes, qvi ut in macro* ongo me* Cofmo dubia creant multa, fie in microcofmo multis fcatent incertis. Ex hactenus obfervatis deducta feqvens opinio fua non videtur de* ftitui probabilitate, qvae ftatuit, glandulas cribra effe, hoc modo con* diata. [XV] OBSERVATION UM SPECIMEN 191 formata, ut, dum ex arteriis in venas per capillaria tranfit fangvis, liberatae a fangvinearum amplexibus ferofae partes caloris vi per con* venientes fibi poros expellantur in capillaria lymphaticorum, con* currente nervorum extremis venis affixorum directione, elicito per fenfuum perceptionem mentis imperio fubjecta. Et haec qvidem de glandularum natura in genere dicta, qvibus addantur feqventia. I. Lacrymae videntur efle humoris palpebras naturaliter oblinentis, Lacryms. ex glandulis per manifefta vafa eo delati, certo animi motu aucta qvantitas; pari ratione ac delicatorum ciborum praefentia falivam movet appetenti, ut non opus fit ad nervorum fuccum, cerebri ferum, arteriarum immediatam exfudationem confugere. An, qvos femel iterumqve in cornea obfervavi non fine admiratione, pori qvan* dam aqvei humoris tranfmittant partem, nondum aufim affirmare: vidi qvidem per poros exeuntem humorem, led ipfine tunicas ad* fcribendus fubftantiae, an ab inclufa aqva deducendus, non facile ante ulterius examen determinavero, cum id nunqvam, nifi aliud agendo, tentatum. II. Cum in ventriculum a litis in auribus, oculis, naribus, ore toto Humor &. oefophago glandulis ferofus Temper defluat humor, interiorqve ventriculi. ventriculi crufta, fi prematur, humorem exfudet, alias cocta reliqva fubftantia durior fit, nee ullos fibrarum agnofcens ductus veri paren* chymatis referat fpeciem, qvis dubitabit de fontibus ventriculo fero* fum humorem perpetuo fubminilrrantibus? Sed ex cui non fimul evidens, aliud in ventriculo folum praeter reperiri calorem? Ad ufum fi progrediendum, ad partes vocanda Chymia; fed hie extra limites Anatomiae non progrediar. III. Lac in mammis non aliter a fangvine fecerni, qvam alius in Lac. aliis conglomeratis humor, tam diu pro rato habebo, donee, qvi aliunde deducunt, fuas vere defcripferint vias, certisqve circum* ftantiis confirmarint. Clariffimus Antonius Everhardi (qvi non vide* tur attendiffe, unicam fe tantum de lacteis mammarum protuliffe hiftoriam, c\ de freqventiore illarum obfervatione defperaffe, me vero non nifi de lacteis ad mammas loqvi, cum dico, femel illi tantum vifas) ad autopfiam femper provocat. Ego, qva potui attentione maxima, diftenta lacte ubera fubftratis a mufculis feparavi, fed lacte licet tumerent &. mammae ex chyli receptaculum, hinc tamen ad illas nullum videre potui tranfitum. Sed illorum recitaffe hiftorias, tan* 192 DE MUSC. & GLAND. OBSERV. SPEC. [XV] turn non eft refutaffe. Hie per thoracem a thoracico ductu, a recep* taculo ille per abdomen, tertius ab utero per abdominis mufculos, omnes autopfiam crepantes, chylum ad mammas deducunt. Catarrhi IV. Qyi glandulas catarrhorum dixerit fontes, fymptomata expli* cabit facile, cum caput glandulis undiqve obfitum. Id fe docuiffe licet in ultimo De Catarrhis tomo credi velit Clariffim. Schneiderus, tertium fibi repugnantem invenit, ubi iple catarrhorum fontes mem* branas pronuntiat, modumqve defcribit, qvo Natura in his mem* branis vaforum extrema aperit, feroqve emiffo, iterum claudit, nulla glandularum facta mentione. Qyod emendaturus ultimo tomo addit, Naturam, cum claudit vafa, glandularum uti operculo. Sed non vide? tur attendiffe Clariffimus Vir, humoris fluxum effe perpetuum, qvantitatem vero fluentis auctam &. qvalitatem mutatam morbos producere, adeoqve hoc operculorum inventum locum non inve* nire, glandulasqve non opercula effe, fed cribra. Et haec qvidem de mufculis glandulisqve velut qvaedam obfer* vationum fpecimina fufficiant. Non pauca neglecta hactenus, qvaedam etiam d.bw&TOl fices of trust, infer alia he was a Judge in the Supreme Court and Physician in Ordinary to King Christian V. — Bartholin was an influential man of high standing in his own country, the Uni* versity of which was essentially under his dominion. His reputation spread outside his native country to the whole of the then world of learning. This is ac* counted for partly by his personal ac= quaintance with most of the contempo* rary scholars interested in Natural Sci* ence, with whom he kept up an exten* sive correspondence, partly by his ver* satile literary activity. Adding a great many amendments, Bartholin edited his father's Anatomy; it was published se* veral times, and, translated into many languages, it was for a long time the manual most in use in Europe. Besides, Bartholin published various large col* lections of letters, of medical journals and of short treatises on Natural Science, among which the collection that may be considered the first periodical of Natural Science — Acta Medica &■ Philo= sophica Hafniensia, published from 1673 till 1680 — was looked upon with great esteem. As an original investigator Bar= tholin was of less merit, though one important discovery, viz. that of the lymphatic vessels, was made by him in conjunction with his prosector Michael Lyser. The same discovery had been made, however, a very short time before by Olof Rudbeck in Upsala, yet with* 222 NOTES out Bartholin's knowing about it. For this subject see Gosch, Udsigt over Danmarks zoologiske Literatur, vol. II 1. Kjebenhavn 1872. pp.87-131, where the controversy into which Bartholin was led by his discovery, is fully diss cussed. A complete list of Bartholin's writings will be found in Gosch, vol. III. Kjobenhavn 1878. pp. 13-61. See, besides, Dansk hiografisk Lexikon, vol. I. p. 564. (Jul. Petersen.) P. 3. 1. 2 from bottom. fimilis omnino ductus] Ductus Whartonianus. See Adenographia . . . Authore Thoma Whartono. Londini 1656. c. XXI p. 129. P. 3. 1. 1 from bottom. a Cafferio] Ivlii Casserii . . . De Vocis Avditvsq; Organis Historia Ana- tomica . . . Ferrariae 1600. tab. V p. 27. d. P. 3. 1. 1 from bottom and p. 4. 1. 1. from top. ex tuis . . . Inftitutionibus] Tho= ma? Bartholini . . . Anatomia . . . Refor- mata . . . Lugd. Batav. 1651. lib. Ill c. XI p. 362. P. 4. 1. 4-5 from top. a Clariffimo Sylvio] Frans de la Boe Sylvius, born in Hanau, studied at German universities. Having taken his degree at Basle in 1637 he returned to Hanau, where he lived as a medical practitioner, continuing his scientific stu« dies at the same time; in 1638, how* ever, he was entered at the University of Leyden as a medical student. For some time he was a physician in Am< sterdam, where he made the acquaint' ance of Descartes, and in 1658 he be* came professor of Medicina Practica in Leyden. He died in 1672 and is espe* cially renowned for his investigations of the brain (fossa Sylvii), of the glands (the classification into glanduls conglo= hats and conglomerate), and of phy* siological chemistry. See Biogr. Woor- denboek der Nederlanden. vol. XVII p. 1 142, the Introduction to the present Edition and note to [II] p. 20. P. 4. 1. 5 from top. a ... Dno. van Home] Joan van Home, born at Amsterdam in 1621, studied at the University of Utrecht, travelled in Switzerland and Italy, and was afterwards made Doctor in Basle; having stayed for some time in France he eventually became Professor at the University of Leyden. He died in 1671. He made the discovery of the thoracic duct independently of Pecquet (Novus ductus chyliferus nunc primum deline= atus. Lugd. Batav. 1652.). See the In* troduction and Biogr. Woordenboek der Nederlanden. vol. VIII p. 1269. P. 4. 1. 5—6 from top. exhibitus publico ductus ille fu* erat] Compare two letters from Ole Borch to Thomas Bartholin, dated Ley* den March 3, and March 20, 1661, found in Epist. Medicin. Cent. III. Haf* niae 1667. No. LXXXV pp. 362-63 and No. LXXXVII p. 376. P. 4. 1. 7 from top. Gerard. Blafius] Gerard Blaes was the son of Leonard Blaes, the Dutch ar* chitectto King Christian IV oi Denmark. He studied medicine in Copenhagen and Leyden and was made Doctor at the lat* ter place. By the time of Steno's arrival in Amsterdam he was physician at the NOTES 223 Athenaeum there. He died in 1692. Blaes displayed a vast literary activity; his commented edition of Vesling's Syn= tagma Anatomicum, Amsterdam 1666, and his Anatome Animalium, ibid. 1681, are his best known publications. See the Introduction and Biogr. Woorden= boek dev Nederlanden. vol. II p. 598. P. 4. 1. 10-11 from top. in fuis ad Eyffonium litteris] Henricus Eyssonius, born in Groningen, was in 1658 made Doctor and two years after Professor of Medicine at the Uni* versity of his native town. He died in 1696. See Biogr. Woordenboek der Ne= derlartden. vol. V p. 311. P. 4. 1. 12-13 from top. de Medicina Generali fcripto] Steno made his discovery on April 7, 1660. The two letters mentioned above (see note to p. 4, 1. 5 — 6 from top) of Ole Borcb's in which the latter mentions Blaes' intention of claiming the right to the discovery, are dated March 3 and March 20, 1661. This letter of Steno's has the date of April 22; in the meantime Gerardi Blasii . . . Medicina Generalis. Amstelaedami 1661, had appeared. In the Preface of this book the following passage is found: In Re ipfa vix aliquid novi, quod com Jiderationem mereatur. Quid accejferit, facile ipfe obfervabis, haec noftra cum aliorum hactenus editis fcriptis confe= xens. Vnicum hoc moneam cogor, Duc= tus falivales in maxilla fuperiori fefe exhibentes, de quibus pag. 64. mention nemfeci, inventis novis accenferi deberi, utpote ante annum, & quod excurrit, a me, privatis exercitiis anatomicis occu= pato, in capite vitulino primiim repertos, ac dein, occafione commodafe offerente, in Nofocomio Leydenji, a Pr. Iuvene Nicolao Stenonis, Hafnienfi, Difcipulo meo induflrio, in capite humano, ante paucos menfes, Spectatoribus exhibitos. The same work has, Cap. XIII. De Sa= liva, pp. 63 — 64: Saliva humor ejl, ca= lidus, moderate, &■ Jiccus, tenuis, fpu= mofus, albicans, dulcis, exfero confians, caloris ope a majfa fangvinea in g/an= dulis maxillaribus fegregato, &~ hinc per ductum falivalem in maxilla fuperiori deque ac inferiori notabilem; ad glandu= las oris anteriores delato, ut inde motu linguae expreffus, guflationi, majhcatio= ni, deglutitioni, imb ad ventriculum de- latus chylificationi inferviat. P. 4. 1. 15 from top. per Fratrem] Gerard Blaes bro- ther, Joan Blaes, was a barrister and an amateur poet. P. 4. 1. 6—7 from bottom. Whartonum ad partes vocare] A- denographia . . . Authore Thoma Whav= tono. Londini 1656. P. 4. 1. 1 from bottom. Dn.Jacobo Henrico Paulli] Jacob Henrik Paulli, born 1637, was the son of Simon Paulli, the Anatomist and Bo- tanist. Having been the prosector of Thomas Bartholin for some time he went to study abroad. He became Professor Designatus of Anatomy at the Univer* sity of Copenhagen but was eventually appointed Professor of History; aban- doning this chair he went to Holland and England as a diplomatist; he was afterwards knighted under the name of v. Rosenschild. See Dansk biograjisk Lexikon, vol. XIV p. 298. (L. Laursen.) P. 5. 1. 2 from bottom. in ilia ... difputatione] Disputatio 224 NOTES Anatomica De Glandulis Oris, &■ nuper obfervatis inde prodeuntibus Vasis Pri= ma (6- Secvnda). Lugd. Batav. 1661. The defence of these dissertations took place on the 6th and 9th of July; they are to be found as No. [II] of the pre* sent Edition. See moreover List of Ste= no's Writings in vol. II. P. 6. 1. 12-13 from top. falivales glandulae duas, interi* or unam, alteram exterior, fibi af« fociarunt] Glandula salivalis exterior and interior d: glandula submaxillaris and sublingvalis. See Adenographia . . . Authore Thoma Whartono. Londini 1656. c. XXI p. 128. P. 6. 1. 16 from bottom. tibi, ut qvi primus haec vafa de« texifti] Pecquet in 1649 found the tho« racic duct in a dog (Joannis Pecqveti . . . Experimenta Nova Anatomica, Qyi= bus Incognitvm Hactenvs Chyli Recep= taculum, &■ ab eo per Thoracem in ra= mos ufque Subclavios Vasa Lactea de= teguntur. . . Parisiis 1651). The thoracic duct was found independently by van Home, that published the discovery in 1652 (see note above to p. 4. 1. 5 from top). Thomas Bartholin was the first who demonstrated the duct in man : De Lacteis Ihoracicis in homine brutisq; nuperrime observatis . . . Hafniae 1652. This was followed by his discovery of the lymphatic vessels: Vasa Lymphatica, Nuper Hafniae in Animantibus inventa, Et Hepatis exseqviae. Hafniae 1653. P. 6. 1. 11 from bottom. a Bilfii parti bus] For an account of Lodewijk de Bils see Biogr. Woor= denboek der Nederlanden, vol. II p. 555 and the Introduction. Bils main* tained that all the watery fluids and secretions of the body come from the thoracic duct. Concerning his contro* versy with Thomas Bartholin, see those of Steno's writings which follow imme* diatly after this Letter, and furthermore Gosch, Udsigt over Danmarks zoolo= giske Literatur, vol. II 1, Kjebenhavn 1872, pp. 117-131. Thomas Bartholin's reply to this Let* ter from Steno is found in Epist. Me= dicin. Cent. III. Hafnise 1667, No. XXV pp. 95-98. II de glandulis oris 6, novis inde prodeuntibus saliva: vasis. Steno's Disputatio Anatomica De Glan- dulis Oris, &■ nuper obfervatis inde prod= euntibus Vajis was published in Ley* den in 1661. It was reprinted in 1662 as the first of the four Treatises found in Nicolai Stenonis Observationes Ana= tomicx, Quibus Varia Oris, Oculorum, 6- Narium Vafa defcribuntur, novique falivx, lacrymarum &■ muci fontes de= teguntur, Et Novum Nobiliffimi Bilfii De lympha? motu &■ ufu commentum Examinatur &■ rejicitur. Lugd. Batav. 1662. The text of this second edition, which was corrected and somewhat en« larged by Steno himself, has been made the basis of the present Edition. In the following notes attention is called to any divergency of text in the two edi<= tions, unless being quite unconsiderable. P. 11. This Dedication is found both in the edition of 1661 and in that of 1662; NOTES 225 but the wording is somewhat different in the two editions. In the dedication to Otto Krag the words . . . gravijjimo, arcis &■ tervitovii Neoburgenjis in Fio- nia1) Gubernatori are only found in the edition of 1662. The last part of the De» dication runs as follows in the edition of 1661: . . . Maecenatibus , &■ Promo* ioribusfuis obfequio seternum devinctus obfervationes hafce Anatomicas Offert NICOLAUS STENONIS Auth. S. Refp. P. 11. 1. 2 from top. D. OTHONI KRAGIO] Otto Krag (1611 — 1666), who belonged to a Danish family of ancient nobility, was at this time the Danish Ambassador to the Netherlands. He was a dauntless and intelligent man. In 1653 he had be* come a member of the Imperial Coun* cil of Denmark, and in the Parliament of 1660, when hereditary absolutism was being introduced in Denmark, he proved a powerful advocate of the rights of his class. See Dansk biografisk Lexi= kon, vol. IX p. 440. (J. A. Fridericia.) P. 11. 1. 8 from top. D. D. JOHANNI JOH. SVA* NINGIO] Hans Svane or Svaning (1611 — 1668), an imperious and ambi* tious man, at the time of the session of the Parliament in Copenhagen in 1660 Bi* shop of the Diocese of Zealand, was a staunch promotor of the introduction of absolute government in Denmark. For his zeal in this cause he was rewarded in va< rious ways by the King, Frederik III, e. g. by being appointed Archbishop, in which office he has been the first and the only protestant of all the divines, on whom ') Neoburgum] Dan. Nyborg. Fionia] Dan. Fyn. that title has been bestowed, the office never having been filled after his death. P. 13. 1. 7 from top. a Protogene] Protogenes was a Greek painter from the fourth century B. C. He enjoyed a widespread repu* tation, and was especially admired for his scrupulosity as regards the execution of his pictures. On a single painting of his he is said to have been at work for seven (or eleven) years. P. 14. 1. 11 from top. Dxdalea junctarum coagmenta= tio] Daedalus, a legendary personage of Greece, used to be considered the architect of any ancient building all over that country. He was also supposed to have built the famous Labyrinth at Crete. P. 14. 1. 19 from top. Apelles] Apelles was one of the most renowned painters of the olden time. He was a friend of Alexander the Great, whom he painted a great many times; he was, in fact, the only painter, by whom the king permitted his por* trait to be made. IN the edition of 1662 and the re- print of 1680 the following poem is found after the Preface. IN NOVOS SALIVA & LACRYMARUM DUCTUS. Dum non nota Jietit tubulorum larga propago Caicis membra fecans gyris, queis rofcida labxa Supra infraque madent, gingiva;, lingua, cibufque Gutture demiffus : queis lumina flumina fiant Per maeftas delapfa genas torrentia, quando Mens trepidat concuffa metu: queis ftillat oborto Lsfum Aquilone caput, madidique infantia nafi. Sudoris, muci, lacrymarum fpiffa tegebat Umbra vias, nulli conftabat fontis origo, Qui membra ac vultum fpumosa immergeret unda. Irrita languentum votiva tabella, nee Artis Satfcecundus erat labor, AJlhmate quando calebant Ora, movente diu ftomacho faftidia tujji. Glandula fpreta [latex nam fub lare conditur illo, 226 NOTES Divite qui vena per totos fpargitur artus] Has turbas dedit, &■ doctos commifit acerbo Sefe inter bello, nunc hunc nunc mordicus ilium Ufum affignantes, alii nam Tubera fulcra Vaforum dixere, locum complere vacantem Ancipites alii, nee, queis tua pagina furgit, Argumenta valent imos referare receffus, Candide Varthoni, licet in penetralia miffus. Fata obftant, nomenque tuum, laudefque perennes, Optime Stenoni, nam primus nubila tecta, Tecta umbrofa, angusta petis, primufque recludis Oftia claufa domus, fecretaque ditia pandis lam nobis, famamque tibi, famamque repertis. His fortunatus, nee guttis grandibus ora Humectes unquam, nee, Ji vel Nejlora1) vincas. Poena fenum, pituita tuis Jit noxia membris. Matth. Iacobi Matthiades.') P. 17. 1. 1 from top. cum convicto a Socrate Arifto= demo] Xenophon, Memorabilia Socratis (Anouvrtuovevuarct) I 4, 6 f. P. 17. 1. 1 from bottom. ev :topcpupct ni&i\xov venerantes] A proverbial saying concerning bad things and persons, whose folly shows itself, notwithstanding their splendour. See Paroemiographi Graecied. a Leutsch. Gottingae 1851. II p. 614 (Apostolios XIV 32). P. 17. 1. 1 from bottom. Silenos^/ci'biacjis tranfeant] Pla= ton, Convivium (Xrumfoiov) c. XXXII Oqui yap on. ^uoiorctrov civjtov elvai roiq XeiXnvoic rouroic; roiq ev toic ep- ') Nestor, King of Pylos, when a very old man, took part in the expedition against Troy. *) Matthias Jacobxus (1637-1688) was the son of the Bishop of Aarhus in Jutland (Denmark), Jacob Matthiesen, D. D., who was married to a sister of Thomas Bartholin. Matthias J acobxus in 1664, having travelled four years abroad, was appointed Professor at the University of Cos penhagen, to a chair which had originally been intended for Steno. He was a brother of Jens (Janus) Jacobxus and oi Steno's future pupil Holger (Oligerus) Jacobxus, both of whom be» came, too, Professors at the University of Co» penhagen. uoyXucpeiotq xa&rtuevotc;, ouorivacj epyd£- ovtcu oi brtuioupyoi cupiyyacj f\ auXouc; exovra<; • ot bixctbe btoix&evrec; tpaivovTat evooftev dydAuata exovrecj Oecov. P. 18. 1. 7 from top. forfan &. qvae non intellexi] Di* ogenes Laertius II 22. Euripides asks Socrates, what he thinks of a book of Heraclihis '; Socrates replies: "A uev cuvnxa, yevvaia, oiuai be xai & uf| Ouvf|xa. P. 18. 1. 15 from bottom. cum fpongiis communia] SeeHi'p= pocrates, Tiepi 'A&evcov. Ed. Littre. vol. VIII p. 556. P. 19. 1. 15 from bottom. Gerardum Leonardi Blafium] The edition of 1661 here and in § 13 [p. 23 in the present Edition] has in» stead of Gerardum: Johannem, which was the name of Blaes' younger bro» ther [see note to I p. 4. 1. 15 from top]. This mistake, as being indicative of Steno's unreliableness, was much dwelt upon by Blaes in a long letter to Tho= mas Bartholin, dated Amsterdam July 16, 1661. See Epist. Medicin. Cent. III. Hafnice 1667. Epist. XLIII p. 164. The edition of 1680, which appeared after Steno's having given up scientific stu» dies altogether, has once more the wrong name instead of the right one in the same two places. P. 19, 1. 4 from bottom. tam brevi] These two words are not found in the editions of 1662 and 1680. P. 20. 1. 17 from top. a Clariff. Whartono defcriptas] See Adenographia . . . Authore Thoma NOTES 227 Whartono. Londini 1656. c. XXI p. 128 and c. XXII p. 137. P. 20. 1. 17-18 from bottom. qvas conglomeratas . . . Sylvius appellat] To the editor's knowledge Sylvius spoke of his classification of the glands, into glandulae conglobatae and conglomerates , for the first time in a dissertation entitled De lienis &■ glan= dularum usu. Lugd. Batav. 1660. Imme* diately below Steno quotes from the se« cond edition of this dissertation, which is found as No. V in: ... Sylvii . . . Disputationum Medicarum Pars Prima . . . Amstelodami 1663. Glandulae con= globatx correspond to those now called the lymphatic glands, glandulae conglo= merata? to the other glands then known: the pancreas, the submaxillary gland, &c. P. 20. 1. 6 from bottom. exfurgentes] Here follows in SyU vius: quales pancreas exfijlunt, &■ thy> mus, &C. P. 21. 1. 1 from top. duo genera reperiuntur] Olof Rudbeck first discovered the lymphatic vessels, which come from the liver; these he called ductus hepatici aqvosi. Later he found other lymphatics, and these he called vasa glandularum serosa. See Nova Excercitatio Anatomica, Exhibens Ductus Hepaticos Aquosos, &■ Vasa Glandularum Serosa . . . ab Olao Rud= beck. Arofiae 1653. P. 21. 1. 3-4 from top. contenta . . . deponant] As related in the Introduction, Steno considered the ducts of the glands then known (duct. Wirsungianus, Whartonianus, Ste= nonianus) as analogous with the lympha' tics of the conglobate (d: lymphatic) glands. P. 21. 1. 16 from top. Hippocr. Lib. de Gland.] Ilepl •Aoevcov. 4. Ed. Littre. vol. VIII p. 558. P. 21. 1. 16 from bottom. Zwingerus in tabulis exponit] See Hippocratis Coi Afclepiadeae gentis facrse coryphaei Viginti Dvo Comment tarii Tabvlis illuflrati . . . Tbeod. Zwin- geri Bas.ftudio &■ conatu. Basileae 1579. p. 381. P. 21. 1. 14 from bottom. acturum ait] Ilepi Aoevmv. 7. Ed. Littre. vol. VIII p. 560. P. 21. 1. 8 from bottom. Epidem. I, feet. 3] Hippocrates, Ilept 'Embnuirov I 3 passim. See espe» cially Ed. Littre. vol. II p. 660. Here and elsewhere a swelling of ret napd t& cord in several patients is mentioned. P. 21. 1. 4 from bottom. Celfus Pliniusqve] Celsi De Me= dicina Libri VIII, lib. VI. c. XVI. - C. Plinii Secundi Naturalis Historian Libri Triginta Septem. Several places in the following books: XX, XXII, XXIII. XXIV, XXV, XXVII, XXVIII, XXIX, XXXII, XXXV. P. 22. 1. 4-5 from top. fcrofulis affectas] Ed. Lugd. Batav 1680 has: affecta. P. 22. 1. 19 from bottom. pondere expreffit Dn. U^Tiarro* nus7 Adenograpbia, c. XVIII pp. 119 -120 and c. XX p. 125. 3nijff = 17.6 228 NOTES grammes, 3ijff = 9.8 gr., 3iij = 11.7 gr., 3ij = 7.8 gr., gxj = 340 gr., Siiijff = 141 gr., giiij = 125 gr. P. 22. 1. 3 from bottom. qvinti paris ramus durior] d: Ner= vus facialis. See Thomae Bartholini A= natomia . . . Reformata. Lugd. Batav. 1651. Libellus III p. 454: . . . unde Ga* leno alii nervi molles, alii duri . . . Om= nes vero partes motum voluntarium ha= bentes duriores accepere nervos, quia durum ad agendum eft magis aptum, molle ad patiendum. P. 23. 1. 9 from top. Gerar. Leon. Blafio] See note to p. 19. 1. 15 from bottom. P. 24. 1. 3 from top. Cafferius fcribit] See note to p. 3. 1. 1 from bottom. P. 24. 1. 4-5 from top. Praefidem in fuis ad Vefalium commentariis] A. v. Haller (Biblio= theca Anatomica I. Tiguri 1774. p. 434) while mentioning the writings of van Home, says with regard to this passage in Steno: Commentarius in Vesalium, Stenonio dictus, undique periiffe videtur. P. 24. 1. 13 from top. qvi ad expreffionem parum fa« cit] Ed. Lugd. Batav. 1661 has qvae instead of qvi. P. 24. 1. 19-20 from top. in prima . . . difputatione] Dis= qvisitio Anatomica De Dvctibvs Sali= valibvs Prima Qvam Svb Praesidio Io= annis van Home . . . Proponit Iohannes Nvck . . . Lvgd. Bat. 1656. § V. (In Dispvtationvm Anatomicarvm Selecta= rvm Volvmen I Ad Chylificationem Collegit, Edidit, Praefatvs Est Albertvs Haller. Gottingae 1750.) P. 25. 1. 3 from top. conglobata glandula] The word conglobata is not found in Ed. Lugd. Batav. 1661. P. 25. 1. 4 from top. Whartonus obfervarit] Ed. Lugd. Batav. 1680 has obfervavit. P. 25. 1. 14-15 from top. glandulae huic tribuuntur] Ade- nographia, c. XX p. 127. P. 25. 1. 16 from bottom. ab hoc oriundi] These words are added by Steno, or rather, ab hac orU undi, as all the editions have it. P. 27. 1. 13-15 from top. Sed &. . . . videntur] These two lines are not found in Ed. Lugd. Batav. 1661. P. 27. 1. 13 from top. apud Aqvapendentem] See Opera Chirvrgica Hieronymi Fabritii Ab Aqva- pendente . . . Francofvrti 1620. Pars II lib. II c. XXXI De Vulneribus Genarum. p. 901 . . . fed verfus aurem foraminu= lum anguftiffimum vix oculis confpicu= um, apparet, per quod, potijjimum vbi patientes madunt, tanta copia exit limpid das aquae, quae eft veluti lachryma ab ocu= lis emiffa, &■ durat aliquando vnum, alU quando duos menfes. Vnde, &■ quo modo effluat, ego certe nefcio . . . (The original edition is printed in Paris 1613 [?]). P. 27. 1. 17-18 from bottom. oftiis per tunicam hiant] These are the minute ducts, which are now NOTES 229 called ductus Rivini. Rivinus described them in a corollary to his Disputatio de dyspepsia. Lipsiae 1678. (Haller, Bibliotheca Anatomica I p. 649), re* printed in Augusti Quirini Rivini . . . Dissertationes Medics Diversis Tempo* ribus Habitae . . . Lipsiae 1710, p. 425. — The last discovered of the greater ducts of the salivary glands, has first been described by Caspar Bartholin, Thomas filius, in De Ductu Salivali Hactenus non descripto Observatio Anatomica. Hafhiae 1684. P. 27. 1. 1 from bottom. Adenogr. c. 22.] Cap. XXII pp. 142 —143. P. 143: Concludo igitur, falivam proprie Jignificare debere, liquorem per ductus falivales effufum; fputum tufsi rejectum, excrementum pulmonum; hu= morem e naribus &■ fupra palatum, pi= tuitam cerebri; verum muccum tonfilla= rum, materiam Mam, quae per tonfillas, de quibus nunc agimus, excernitur. P. 28. 1. 4 from top. Schneideri De Catarrhis] Con= radi Victoris Schneideri . . . Liber De Catarrhis Tertius . . . Wirtebergae 1661. sect. II. c. III. p. 501. P. 503: Ilia membrana, que additamentum offis Oc« cipitis in ultimo palato involvit, ilia, m= quam, pituitam condit, continet &■ emit- tit. — Schneider was the first who spoke against the then generally adopted the* ory that the mucus of the nose, the mouth and the throat had its origin from the brain, from where it passed down through the minute holes in the bones of the skull. Schneider maintained that the mucus originated from the mem= brana pituitaria anterior and posterior (the mucuous membrane of the nose and the upper part of the throat) and was formed by a sort of exudation from the arteries of the mucuous membranes. P. 28. 1. 7 from top. foraminulis] Ed. Lugd. Batav. 1680 has foraminibus. P. 31. 1. 8 from top. raram . . . hiftoriam refert] Tho= mae Bartholini Historiarum Anatomica? rum Rariorum Centuria HI. &■ IV. Haf* niae 1657. Cent. Ill hist. LXXVII p. 152: Ptyalismus Jingularis. P. 31. 1. 16 from top. non poterunt non] The latter non is not found in Edd. Lugd. Batav. 1662 and 1680. P. 31. 1. 10 from bottom. De Morbis a Serof. Coll.] Selec= tiorvm Observationvm Et Consiliorvm De Praztervisis Hactenvs Morbis Ajfec= tibvsqve Praeter naturam ab aqua, feu ferosa colluuie &■ diluuie ortis Liber Singvlaris. Avthore Carolo Pisone. Ponte Ad Monticvlvm 1618. sect. I theor. 4. pp. 34—35. — P. 35: Quasfi verafunt, vt funt verijjima, certe concludere ejl caput ejfe veluti labrum feu cajlellum natum dijhibutioni aquae in varia membra eius vfus indiga. P. 31. 1. 8 from bottom. feet. 2. part. 1. c. 2.] ibid. pp. 39-41. P. 32. 1. 7 from top. A cerefero alii] As to the theories most current at the time of Steno con* cerning the genesis of the saliva and other secretions, the reader is referred, in ad« dition to the notes to vol. I p. 28. 1. 4 from top, to Wharton's Adenogr aphia, partly to the introduction, partly to 230 NOTES chapters XXI and XXII, especially pp. 136 and 144. P. 32. 1. 8 from top. Nobil. Bilfius] In a pamphlet prin* ted in Dutch in 1658, but soon trans* lated into Latin under the title D< Ludo- vici De Bils Toparchae in Koppenfdam- me, Bonem, &c. Epistolica Dissertatio: Qua vevus Hepatis circa Chylum, &■ pariter ductus Chiliferi hactenus dicti ufus, docetur1) Bils had maintained that the view adopted on the basis of the discoveries made by Pecquet, van Home and Th. Bartholin concerning the function of the chyle and the thoracic duct, was erroneous. Bils asserted that the chyle was conveyed to the liver by the vena? mesaraicae mixed with blood and that the thoracic duct, which he called ductus roriferus, only carried lymph, which was led from there direct all over the body in small canals, to appear as tears, saliva etc. P. 32. 1. 9 from top. Anton. Deufingius] Deusing, who had never made any anatomical inve* stigations himself but was a man of ex* tensive reading, sided with Bils in the long and troublesome quarrel, which arose through Bils pamphlet mentioned above; a quarrel in which Bartholin joined with ardour and in which Steno, too, was involved for a time. In his Exercitationes PhyJico= Anatomic a?, De Nutrimenti in Corpore Elaboratione. Vbi De Chylificatione, & Chyli Motu; Sanguificatione ; Depuratione Alimenti; ') This pamphlet is found (pp. 20—23) in : Epi° stola Apologetica Ad Magnum Th. Bartholinum Regium in Regia Hafnienfi Profefforem Anato° micorum Coryphxum De Calumniis NobiltfT. Iax° dovico Bilsio a CoppenJ damme, Bonem, &c. D° . . . impactis . . . Roterodami 1661. Itemque Spiritibus. Quibus adjecta ap= pendix in qua examini acjudicio aliorum fubjiciuntur varias de chyli motu et nu= trimenti in corpore elaboratione nee non de admiranda anatome nobiliss. viri D. Ludovici de Bils. Groningae 1660, Deusing asserted, that the saliva had various sources. The greater part of the saliva was, according to him, the watery fluid which came from the larger sali* vary glands through their excretory ducts, and which was first conveyed to the glands from the ductus roriferus through certain ramuli roriferi; but moreover the saliva consisted of the more watery part of the serum, which through small ar* teries was exuded into the mouth; and lastly of a watery matter which passed from the brain through the foramina in the sphenoid bone to the glands men* tioned above or direct into the mouth. — Steno' s reference to Deusing here, and again in § 42. (vol. I p. 42 of the pre* sent Edition) called forth a pamphlet from Deusing: Vindiciae hepatis redivivi, 1661, to which Steno replied with his Treatise Responsio Ad Vindicias Hepa= tis Rediviviin Observationes Anatomical . . . 1662 (No. IV of the present EdU tion. vol. I p. 61. See the introduction to the notes to it.). P. 32. 1. 13 from bottom. ur|T£ &7tojuv>TT£Cttai] Xenophon, Institutio Cyri (Kvpow Tiaibeia) I 2, 16: Aidxpov |.iev yap eti xai vuv eon Ilep- oaic; xai to ajiojrnteiv xai to d^ouuTTe- otfai, xai to cpucric; ueorouq cpaivec&at. P. 32. 1. 10 from bottom. eon xpi'oiq] Hippocrates, De Dizeta (riepi Aian-riO III 70. Ed. Littre. vol. VI p. 608. NOTES 231 P. 33. 1. 7 from bottom. Spiritus aqvae &. oleo jungi pot* erit] On several chemical terms men* tioned in the sequel and elsewhere in Steno's writings, information is to be found in Totius Medicinae Idea Nova, Seu Francisci Silvii De Le Boe . . . Opera Omnia . . . Acceffere Chymia . . . Parisiis 1671: Lib. II p. 287. 11. Spiritus a volatilitatis Jimilitudine, quam cum Mercurio habet, dictus Mercurius vocatur vulgb Chymi= cis quicumque liquor activus penetrans purgativus ut fpiritus vini rectificatus, fpiritus falis nitri; fpecialiter tamenfpi* ritum vocant ilium qui ex rebus ferment tatis paratur, ut eft fpiritus abfynthij, rofarum, cardui benedicti; maxime ta= men proprie fpiritus appellari debet, quidquid eft fumme volatile in rebus, adeo ut ejus notio in rebus fola vola= tilitate conftftat; atque hoc modo repe= ritur triplex fpiritus, injipidus, fulphu= reus & falinus. P. 287. 12. Sulphur vocatur quidquid eft inflammabile . . . P. 287. 13. Sal dicitur quidquid po= teft incinerari &. eft acre, eftque duplex fixum 6- volatile; utrumque refpectu ig= nis fie dicitur. P. 290. 13. Menstruum Chymicis di= citur liquor habens vim corpus aliquod folvendi.fic dictum, quia plerumque per menfem Chymicum, id eft 40. dies cum corpore folvendo in digeftione ponitur, quo tempore corporis fit folutio . . . P. 303. 23. Spiritus nitri. p. 307. 32. Butyrtim antimonij. p. 308. 35. Bezo* ardicum miner ale. p. 312. 45. Oleum tartari per deliquium. p. 324. 56. Aqua fortis. P. 34. 1. 10-11 from top. Mercurii mobilitas. . . impedita] This may refer to Basilius Valentinus's having discovered that spiritus vitrioli (sulphurous acid) discharged mercurium from a solution of perchloride of mer* cury, or to the current belief that mercury folidified when poured into boiling lin* seed oil. P. 34. 1. 18 from top. parum fpiritus volatilis, &■ mi= nimum falis lixiviofi] De Lienis 6- Glandularum Usu (dated March 13, 1660) is found as Disp. V in Dispu= tationum Medicarum Pars Prima. Am* stelodami 1663. See p. 72. — Spiritus volatilis = volatile matter. 5a/ lixiviosum — alkaline salt. See the note above to p. 33. 1. 7 from bottom. P. 35. 1. 5-6 from top. hanc jravOTiefiuiav] A conception which is frequently mentioned by Ari= stotle. See, for instance, De Generatione Animalium (Ilepi Zcocov yEveoecoc;) lib. VI c. 3: . . . eicsi Y<*P Tivet; oV cpaoi rr\v yo- vi\\, ut'av oucav, o!ov jravonepuiav etvat nva TtoXXebv. P. 35. 1. 11-12 from top. negans argumentatio] The editions Lugd. Batav. 1662 and 1680 have ne- gativa. P. 35. 1. 17-18 from bottom. D. Olao Borrichio] Ole Borch (1626—1690), son of a clergyman, was born in Norre*Bork in Jutland (Den* mark). In 1644 he entered the Univer* sity of Copenhagen, going in for the study of Anatomy, Botany, Chemistry, Philosophy, Philology and Poetry. From 1650 he was an usher in Vor Frue Skole (Our Lady's School), where he was Steno's teacher; and from 1655 and five 232 NOTES years onward, as well as later, he was the tutor of the sons of Joachim Gers= dorf, the Lord High Steward of Den* mark. He distinguished himself when taking part in the defence of Copenha* gen in 1659, and immediately after he was appointed Professor of Philology, Botany and Chemistry. He went abroad for six years, visited Holland, where Steno met him, England and France, became Doctor in Angers in 1664, and was then afterwards in Florence and Rome. Having returned to Denmark in 1666 he became Medicus Regius and founded the Collegium Medicamm (ge* nerally called Borchs Kollegium) for sixteen undergraduates. — Ole Borch was a most capable and learned man, who enjoyed a great reputation among his contemporaries, especially, perhaps, for his works on philology and poe* try; but his studies in chemistry are of great merit, too. Besides numerous chemical treatises in Acta Hafniensia Ole Borch composed two books on the history of chemistry: De Ortu, Et Progressu Chemiae Dissertatio, Hafniae 1668 and Hermetis, AZgyptiorum, Et Chemicorum Sapientia . . . Hafniae 1674, and one on practical chemistry: Do= cimastice Metallica. Hafniae 1677. In medical science, too, Ole Borch was a man of great ability. See Dansk biogra= Jisk Lexikon, vol. IT p. 500 (H. F. Rot= dam, M. CI. Gertz, S. M. Jergensen, Jul. Petersen.). P. 35 1. 6-7 from bottom. qvi ovyxpiGw rerum &. bidxptoiv admittunt] Xoyxpiotc; and cudxpicnc; (composition and separation) are the technical terms for the explanation of the coming into being and the passing away which was given by Democritus (the Atomists) and Anaxagoras. In the ancient philosophy the colours are ge* nerally explained to be mixtures of the primary colours (Aristotle and his School). P. 36. 1. 1 from top. bezoardicum minerale] Bezoardi= cum minerale means the precipitate ob« tained by the adding of nitric acid (spiritus nitri) to trichloride of antimo* ny (butyrum antimonii). P. 36. 1. 7 from top. de Benneti experimento] See T7ie= atri Tabidorum Vestibulum . . . Per CheU stoph: Bennettum. Londini 1654. c. Ill pp. 10-15. P. 36. 1. 7-8 from top. qvod Pecqvetus in fero obferva* vit] See Ioannis Pecqveti . . . Experh menta Nova Anatomica . . . Eivsdem Dissertatio Anatomica De Circvlatione Sangvinis, Et Chyli Motu. Parisiis 1651. c. II p. 5. P. 36. 1. 18-19 from top. nifi Democritus forte aliqvis] About the capability of the famous Greek philosopher Democritus (born in 460 B. C.) of seeing through everything all that was concealed from other people, many legends are found in ancient hi* story; his fame increased through the Middle Ages when he was looked upon nearly as a sorcerer. P. 36. 1. 19-20 from top. lac virginis] By lac virginis Steno most likely meant tincture of Benzoes (Boerhave). In Libavius lac virginis is an opalescent solution of sugar of lead. NOTES 233 P. 36. 1. 19 from bottom. lac tithymallorum, lac cichorea* ceorum] The juice of certain plants belonging to the euphorbiaceae and com= positae. P. 37. 1. 10 from top. de fucco benigno &. chylo pro* pinqviore] See Novus Et Genuinus Hominis Brutique Animalis Exovtus. Authore Anthonio Everardi. Mediobvrgi 1661. p. 18. P. 38. 1. 18-19 from top. Spicileg. de Vaf.Lymphat. I. c. 7.] Thomae Bartholini . . . Spicilegium Ex Vasis Lymphaticis . . . Hafhiae 1655. c. VII p. [4]. P. 38. 1. 17 from bottom. De Circulat. Sangv.&Chyl. Mot. c. 5.] See Dissertatio Anatomica De Circvlatione Sangvinis, Et Chyli Motv, c. V p. 40. This treatise constitutes the latter part of Experimenta Nova Ana- tomica . . . Parisiis 1651. P. 39. 1. 12 from bottom. ex CI. Sylvii fententia] See Dis- putationum Medicavum Pars Prima. Am« stelodami 1663. Disp. V p. 66. P. 39. 1. 7 from bottom. De Nat. Deor.] Cicero, De Natura Deorum, I 1, 1. P. 41. 1. 9 from top. qvod 6. CI. tt^Tiarfonus obfer« vaffe videtur] Adenographia, c. XXI pp. 130—131. See also the present Edi* tion vol. I p. 188. III. P. 41. 1. 19 from bottom. Hunc enim ad locum] Hence to . . . flylo concefferit p. 42. 1. 11 from top is not found in Ed. Lugd. Batav. 1661. P. 43. 1. 18 from top. Et hie ille chyli motus] This pas* sage runs as follows in Ed. Lugd. Ba* tav. 1661: Et hie ille chyli motus, quern Jibi demonjhrari in fpicilegio fecundo D. Bartholinus cupzr. P. 43. 1. 19 from top. in Spicilegio Secundo] See Th. Bartholini Spicilegium Secundum Ex Vafis Lymphaticis. Hafniae 1660. c. VII Ludovici de Bils nova experimenta ventilantur. p. 33. P. 43. 1. 19-20 from top. in Refponfione] Th. Bartholini Re= sponsio De Experimentis Anatomicis BiU Jianis Et Difficili Hepatis refurrectione. Hafniae 1661. P. 43. 1. 18 from bottom. in Epiftolica Differtatione] See note to vol. I p. 32. 1. 8 from top. P. 43. 1. 17 from bottom. voluit demonftrare] See Letter from Ole Borch to Th. Bartholin, dated Leyden March 3, 1 66 1 , in Epist. Medicin. Cent. III. Hafniae 1667. Epist. LXXXV p. 364. P. 44. 1. 5-6 from top. ilium dignofcere potuerint] See Letter from Ole Borch to Th. Bartholin, dated Leyden March 31, 1661, in Epist. Medicin. Cent. III. Hafhiae 1661. Epist. LXXXIX p. 382. P. 44. 1. 7 from bottom. § 45] There is no section bearing the 234 NOTES No. 45 in any of the editions. This, as well as other mistakes in the num« bering of the sections, has been cor» rected in the present Edition; so from this place onward the numbers of the sections do not correspond to those of previous editions. P. 44. 1. 5 from bottom. Henrico a Moinichen] Henrik a Moinichen (1631-1709), graduated in Copenhagen in 1650 and studied abroad for some time, especially ana* tomy. He was patronized by Th. Bar? tholin, and after his return he was offered the chair as Professor of Ana« tomy at the University of Copenhagen. He rejected this offer, however, and was appointed Physician of the Royal House* hold. See Dansk biografisk Lexikon, vol. XII p. 39 (G. L. Wad). P. 45. 1. 3 from bottom. colore adhuc tincto] adhuc is not found in Edd. Lugd. Batav. 1662 and 1680. P. 46. 1. 8 from top. lympha etiamnum tumerent] ef= iamnum is not found in Edd. Lugd. Batav. 1662 and 1680. P. 46. 1. 9-10 from bottom. propelleretur lymphaj lympha is not found in Ed. Lugd. Batav. 1661. P. 46. 1. 6-7 from bottom. Antonius Everhardus] Anthony Everaerts was a physician in MiddeU burg in Holland. See Biogr. Woorden* boek der Nederlanden, vol. V p. 243. As to the title of the book quoted see note to vol. I p. 37. 1. 10 from top. P. 47. 1. 2 from top. ad mammas lactis] These words are not found in Ed. Lugd. Batav. 1661. P. 47. 1. 8 from bottom. nifi forte] Hence to . . . ej)ent con= cipiendx 1. 6 from bottom is not found in Ed. Lugd. Batav. 1661. P. 47. 1. 3 from bottom. facta partim vidi] The word par= fun is not found in Edd. Lugd. Batav. 1662 and 1680. P. 48. 1. 5 from top. §51] Section 5 1 is not found in Ed. Lugd. Batav. 1661, but is added in Ed. Lugd. Batav. 1662 as § 52. P. 48. 1. 1 1 from top. Pag. enim 282] In Novus Et Ge= nuinus Hominis Brutique Animalis Ex= ortus. Mediobvrgi 1661. P. 49. 1. 19 from bottom. ut thef. 47. expofui] i. e. § 47. in the present Edition. P. 49. 1. 13 from bottom, inde] Ed. Lugd. Batav. 1661 has unde. P. 50. 1. 1 from top. COROLLARIA] This Corollary ap- pears only in Ed. Lugd. Batav. 1661. P. 50. 1. 5-6 from bottom. qvae Clar. Schneiderus . . . pro* ponit] See note to vol. I p. 28. 1. 4 from top. NOTES 235 III VARLS IN OCULIS & NASO OB. SERVATIONES NOVJE &C. This Letter from Steno to Thomas Bartholin, dated Leyden September 12, 1661, is found in Thomas Bartholini Epist. Medicin. Cent. III. Hafhiae 1667. Epist. LVII p. 224. P. 55. 1. 3 from top. itineri debetur] Steno had been on an excursion in Holland from July 27 to August 14, 1661, in the company of Ole Borch (see Introduction and note to vol. I p. 35. 1. 17— 18 from bottom), Jesrgen Hasebard (see the following no* te) and a couple of foreign students. On this trip he made the acquaintance, amongst others, of Peder Schumacher (see Introduction and Dansk biografisk Lexikon, vol. XV p. 371) and of Born who is mentioned below. P. 55. 1. 6 from top. reduximus Hafebardum] Jergen Hasebard, the son of the Bishop of Viborg (Denmark), Wichman Hase= bard, matriculated at the University of Leyden, September 14, 1661, and was styled pol. et hist. stud. He died in 1670 as Professor Designatus of Odense Gymnasium (Denmark). P. 55. 1. 6-7 from top. Walgefteinium . . . offendimus] Thomas Rasmussen Walgensten, born on the isle of Gothland, studied mathe* matics at the University of Copenhagen and was for many years, until his death, the editor of an almanac. He is found to have matriculated twice at the Uni* versity of Leyden (1657 and 1669), so it was during his first stay in Holland that .Steno made his acquaintance. In 1670 he became Inspector of the King's Model Chamber in Copenhagen, being at the same time entrusted with the super* intendence of the erection of public buildings in that city. Among other works he took part in the equipment of the Large Room in The Great Royal Library. He died in 1682 as Commis* sioner and Provincial Judge on Goth* land during the Danish occupation of that island. See Dansk biografisk Lexi= kon, vol. XVIII p. 218 (G. L. Wad). P. 55. 1. 10 from top. Burr/iiauxilio] Gioseppe Francesco Borri (1625-1695), a native of Milan where his father, himself a member of a renowned family, practiced medicine. He was educated at the College of Jesuits in Rome, and afterwards entered the service of the Papal Court; but when, an enthusiast and a mystic, he endeavoured to establish a sect of his own, he had to leave Rome for Milan to escape the Inquisition (1655). How* ever he kept on working to found a new church and a new state, the su* preme head of which he was to be, so at last an action was brought against him in Rome, and he was burned in effigie. Already during the law*suit he had fled to Holland (1659) and for several years lived in Amsterdam, where he studied chemistry and al* chemy, enjoying a great reputation as a physician. In Holland he made the acquaintance of many prominent Danes, among others of Ulrik Frederik Gylden- leve and Hannibal Sehested, and through them he may have heard about the interest taken by the King of Den* mark, Frederik III, in the science of alchemy. At any rate he went to Co* penhagen in 1667, where he stayed 236 NOTES for three years till the death of Frede- rik III, and was highly esteemed, both as an alchemist and as a physician. In 1670 he set out for Constantinople, but, while on his way, he was captured and conducted to Vienna, where he was sur* rendered at the request of the Papal Nuncio. The action against him was renewed, and in 1672 he was sentenced to be imprisoned for life. He died in 1695 in the prison of the Castle of Saint Angelo in Rome. See Biographie Universelle, vol. V p. 96 and Dansk bio= grafisk Lexikon, vol. II p. 543. (Chv. Bruun). P. 55. 1. 11 from top. Vindicias illius] See note to vol. I p. 32. 1. 9 from top, and the intro* duction to the notes to IV in the pre* sent Edition. P. 55. 1. 11 from bottom. eum Bilfio favere] On Bils see In* troduction. Steno here refers to what he has written about Deusing's position toward Bils' doctrine in his Disputatio Anatomica De Glandulis Oris . . . Lugd. Batav. 1661, theses 25 and 42 (vol. I p. 32 and 42 of the present Edition). With regard to this matter as well as to the remainder of the Letter, see also Steno's reply to Deusing: Responsio ad Vindicias Hepatis Redivivi (vol. I p. 61 in the present Edition). P. 55. 1. 3 from bottom. occafionem Exfeqviarum Hepa- tis] Thorns Bartholini Vasa Lympha= tica, Nuper Hafniae in Animantibus in- venta, Et Hepatis exfeqviae. Hafhiael 653. P. 55. 1. 2 from bottom. Spicilegium tuum] Thomx Bartho= lini . . . Spicilegium Ex Vasis Lym= phaticis . . . Hafniae 1655. P. 56. 1. 1 from top. in Spicilegio Secundo] Th. Bar* tholini Spicilegium Secundum Ex Vajis Lymphaticis . . . Hafniae 1660. P. 56. 1. 2-3 from top. in hoc cardine . . . verfari ais] See Th. Bartholini Spicilegium Secun* dum, c. VII p. 37: In hoc cardine fa= lus obfervationum nojharum volvitur. P. 56. 1. 6-7 from top. in Epiftolica Differtatione] See note to vol. I p. 32 1. 8 from top. P. 56. 1. 12 from top. habebis] Steno sent his Observation nes Anatomies . . . Lugd. Batav. 1662 to Th. Bartholin with a letter dated Leyden January 9, 1662, new style. It is found in Thomx Bartholini Epist. Medicin. Cent. III. Hafniae 1667. p. 262 as Epist. LXV and appears as No. VII in the present Edition (vol. I p. 101). P. 56. 1. 19 from bottom. a Clariff. Borrichio . . . fignifi* catam exiftimem] See Letter from Ole Borch to Thomas Bartholin in Epist. Medicin. Cent. III. Epist. XCIII p. 401. P. 56. 1. 18 from bottom. cum Tractatu de Glandulis Ocu- lorum] Steno's De Glandulis Oculo= rum . . . dated Leyden December 6, 1661, is the third Treatise in his Observation nes Anatomica? . . . Lugd. Batav. 1662, and it appears as No.V in the present Edition (vol. I p. 79). P. 57. 1. 7-8 from top. illam...diverfitatem non inveni] NOTES 237 This refers to Bils' Epistolica Disserta= Ho, where Bils gives a description of his method. See, moreover, Steno's Re= sponsio Ad Vindicias Hepatis Redivivi (IV vol. I p. 64 in the present Edition). P. 57. 1. 18-19 from top. ductum . . . continuum effe] See Letter from Steno to Th. Bartholin in Epist. Medicin. Cent. III. Hafniae 1667. Epist. LXV p. 264 (VII vol. I p. 102). P. 57. 1. 5 from bottom. fit feriaturus] Bils never replied to Steno's criticism. P. 58. 1. 1 from top. Clariff. Golius] Jacobus Golius (1596—1667), who was born at the Hague, came of an ancient and renow* ned family. He studied at the Univer* sity of Leyden till his twentieth year, when he went to live in the country. After some time he left for France, living for a while at La Rochelle ; but he returned to the Netherlands on account of the Religious Wars. Golius was an eminent man of learning, with great knowledge of various branches of science, having applied himself to the study of the classical languages, philosophy, theo* logy, medicine and mathematics; besides he was a good Arabian and Persian scholar, having learned those two Ian* guages during a long stay in Morocco and in the Levant, where he likewise obtained many very valuable manuscripts. In 1629 he became Professor of Mathe* matics in Leyden. Golius was the author of several works of great importance, the best known of which are possibly his Arabian*Latin and his Persian*Latin Die* tionaries (Biogr. Woordenboek dev Ne= derlanden, vol. VII p. 270 and Biogra^ phie Universelle, vol. XVII p. 117.). P. 58. 1. 8 from top. Anno 1661] Epist. Medicin. Cent. III. has erroneously 1666. IV RESPONSIO AD VINDICIAS HE* PATIS REDIVIVI. This Treatise, dated November 28*18, 1661, appeared in the following year as the second of the four treatises in NU colai Stenonis Observations Anatomica? . . . Lugd. Batav. 1662. It is a reply to Deusing's Vindicise Hepatis Redivivi, directed against van Home, whom Deu= sing took to be the real author of Steno's Disputatio Anatomica De Glandulis Oris . . . Lugd. Batav. 1661. See the Intro* duction and the two previous Treatises (II and III, vol. I p. 17 and p. 55 of the present Edition). — The Editor has not been able to find any copy of Deu= sing's Vindicae Hepatis Redivivi. P. 62. 1. 18 from bottom. furtivis coloribus fplendere] Ho= ratius, Epistolse I 3, 19-20: moveat cornicula risum furtivis nudata coloribus. Edd. Lugd. Batav. 1662 and 1680 have both furtivus for furtivis. P. 62. 1. 14-15 from bottom. Chriftiani Rudnicii] Christian Rudnick from Biitow in Further Pome* rania is mentioned in Haller, Bibliotheca Anatomica vol. I p. 604, where he is called Practicus Gedanensis (i. e. from Dantzic), and is put down as the author of a treatise Coecum inteftinum vulpis &■ leporis, printed in^4cfa^4cac/.iVaf. Curios. P. 63. 1. 11-12 from top. Bilfianam . . . opinionem] See In* 238 NOTES troduction and the two previous Treati* ses (II and III of the present Edition) passim. P. 63. 1. 18 from top. nee u 11 a] Ed. Lugd. Batav. 1680 has nulla. P. 63. 1. 13 from bottom. poffis] Ed. Lugd. Batav. 1680 has poffit- P. 64. 1. 6 from top. Ex periment.l.] Ed. Lugd. Batav. 1662 has expiment. 2. — The experiment spo» ken of in Ioannis Pecqveti . . . Experi= menta Nova Anatomica . . . Parisiis 1651, p. 50 is as follows: A collapsed, tied" up bladder, being under great pressure, will expand and swell, as soon as the pressure is diminished. The experiment is referred to here only as an example of something surprising, something not to be expected beforehand. P. 64. 1. 8 from top. Praeception.] Hippocrates, Prazcep* tiones (napayyeXiai) 1 — 2. Ed. Littre. vol. IX p. 252. P. 64. 1. 11-12 from top. Bilfii. . . experimento] See Steno's Disputatio Anatomica De Glandulis Oris . . . passim, especially thesis 42 (vol. I p. 42 in the present Edition); further* more, Ole Borch's Letter to Th. Bar= tholin in Epist. Medicin. Cent. III. Haf* niae 1667. Epist. LXXXV p. 364 and Bils' Epistolica Dissertatio (see note to vol. I p. 32. 1. 8 from top). P. 64. 1. 18 from top. obfervavi praefcriptam a Bilfio methodumj See note to vol. I p. 32. 1. 8 from top and p. 57. 1. 7—8 from top. P. 65. 1. 9-10 from top. Barthol aggreffus eft?] See Ludovici De Bils . . . ad Th. Bartholin num Regium Hafriiaz ProfeJJbrem Epi= stola (dated Rotterdam April 10, 1661). This pamphlet forms pp. 33—39 ot Ludovici De Bils . . . Responsio Ad Admonitiones D> Johannis ab Home . . . Roterodami 1661. P. 67. 1. 1 from top. dicere] See life. Bartholini Spicilegi- um Secundum Ex Vajis Lymphaticis . . . Hafniae 1660, p. 40. P. 67. 1. 16 from top. occafionem Exfeqviarum Hepa= tis] See note to vol. I p. 55. 1. 3 from bottom. P. 68. 1. 3-4 from top. humorem pvaeparave] See Nicolai Stenonis Disputatio Anatomica De Glan= dulis Oris . . . Secunda. Lugd. Batav. 1661. thes. 22. (vol. I p. 31 in the pre* sent Edition). P. 68. 1. 6 from bottom. Zaffii fenfum] Zassius, a physician of Rotterdam, repeatedly came forward as the defender of Bils; see, for instance, Epistola Apologetica Ad Magnum Th. Bartholinum . . . Roterodami 1661, in which pp. 3—11 were written by Zassius (see note to vol. I p. 32. 1. 8 from top). P. 69. 1. 5 from top. ita loqvitur] De Bils . . . Epistolica Dissertatio ... p. 22. See note to vol. I p. 32. 1. 8 from top. NOTES 239 P. 69. 1. 7 from top. ubiqve influit] Bils has ibiqve. P. 69. 1. 11 from bottom. Clariff. Schneid. torn. 3] Conradi Victoris Schneideri . . . Liber De Ca= tarrhis Tertius . . . Wittebergae 1661. P. 554 Schneider enumerates all the places, in which he has found pituita to be secreted: 1) Membrana pituitaria an* terior, quae interiora narium &■ interJH= Hum earum diverjimode involvit, 2) Mem> brana pituitaria posterior, 3) Tonfillae, 4) Ductus Salivales, &. illi Sublingvales, 5) Lingua, ejus'q; vafa, 6) Larynx & Epiglottis. 7) Summa Gula ex Gurgulio. P. 70. 1. 11-12 from top. de Tabaci Fumo] Tabacologia : Hoc est, Tabaci, Seu Nicotianae defcriptio Medico=Cheirurgico=Pharmaceutica . . . Per Iohannem Neandrvm . . . Lvgdvni Batavorvm 1622. This book contains (pp. 228-240) a letter written by Adru anus Falcoburgius (van Valckenburg) (1581-1650), Professor of Leyden and an able teacher, especially interested in pathological anatomy (Biogr. Woorden= boek der Nederlanden, vol. VI p. 36). P. 70. 1. 9-10 from bottom. loqvitur] Edd. Lugd. Batav. 1662 and 1680 have here loqvi eum instead of loqvitur. P. 71. 1. 5-6 from top. de Experimentis Anatomicis BiU fianis] Th. Bartholini Responsio De Experimentis Anatomicis Bilfianis Et Difficili Hepatis refurrectione, Ad Cla- rifsimum Virum Nicolaum Zas. Hafniae 1661. P. 71. 1. 9 from top. Spicileg. 2.] Th. Bartholini Spicile= gium Secundum Ex Vajis Lymphaticis . . . Hafniae 1660. c. VII p. 33. Here and in the remainder of the treatise Steno quotes from the reprint of the fol* lowing year: Thomas Bartholini Spicile= gia Bina Ex Vajis Lymphaticis . . . Am* stelaedami 1661. P. 71. 1. 11 from top. in fine tractatus] ibid. p. 47 in Ed. Hafniae 1660, and pp. 116—117 in Ed. Amstel. 1661. P. 71. L 14 from top. repugnarim] Both editions of Spi= cilegium Secundum (Hafniae 1660 and Amstelaedami 1661) have repugnarim, but Steno has repugnarem. P. 71. L 18 from top. In Refponf. autem p. 10] Th. Bar= tholini Responsio De Experimentis Ana= tomicis Bilfianis . . . Hafniae 1661. Steno quotes from an edition, published the same year in Amsterdam; and p. 10 corresponds to p. 1 5 of Ed. Hafniae 1661. P. 71. 1. 9 from bottom. omnibus notum] Gasparo Aselli found vasa lactea in 1622. His discovery was published in the year after his death: De lactibus s. lacteis venis quarto vaso- rum mesaraicorum genere, novo invento dissertatio . . . Mediolan. 1627. (quoted from Haller, Bibliotheca Anatomica, vol.1 p. 362). The tract on Aselli's discovery exists in several editions, and is also reprinted in Le Clerc &■ Mangetus, Bibliotheca Anatomica, Genevae 1685 and 1699. P. 72. 1. 2 from top. in Epiftolica Differtatione] See note to vol. I p. 69. 1. 5 from top. 240 NOTES P. 72. 1. 4 from top. fe vias] Biljius has vias fe. P. 72. 1. 19 from top. c. 8. Vaf Lymph at] Thomx Bar* tholini Vasa Lymphatica, Nuper Hafhiae in Animantibus inventa, Et Hepatis ex= feqvix. Hafhiae 1653. c. 8. p. 55—56. Steno has, erroneously, c. 7. P. 72. 1. 14 from bottom. in animalibus] Bartholin has in anU mantibus. P. 72. 1. 11-12 from bottom. Vidimus . . . effe fui generis] The word ilia is not found in Steno. Bartholin has fui effe instead of effe fui. P. 72. 1. 10-11 from bottom. Lymphatica nobis dicta] The de* signation vasa lymphatica is due to Bartholin (Vasa Lymphatica, Nuper Hafnix in Animantibus inventa . . . Hafniae 1653). See, also, note to vol. I p. 21. 1. 1 from top. P. 73. 1. 8 from top. Spicileg. p. 104] See note to vol. I p. 71. 1. 9 from top. Page 104. of Ed. Amstelaedami 1661 corresponds to p. 37. of Ed. Hafniae 1660. V DE GLANDULIS OCULORUM NOVISQVE EARUNDEM VASIS OBSERVATIONES ANATOMIC^. This Treatise, which is dated Leyden December 6, 1661, appeared in the fol* lowing year, as the third of the four treatises in Nicolai Stenonis Observa= tiones Anatomicx . . . Lugd. Batav. 1662. See, moreover, Treatise III of the pre* sent Edition. P. 77. 1. 2 from top. D. SIMONI PAULLI] Simon Paulli (1603—1680), who was born at Rostock in Mecklenburg, came to Denmark when only one year of age, his father being appointed Physician in Ordinary to the Queen Dowager Sophie. After having studied at Rostock and Leyden, as well as in Belgium and England Paulli re* turned to Denmark in 1626, where he worked at botany and mathematics, the latter under Thomas Fincke of Copen* hagen. Then he went abroad for a second time, among other places visiting Paris, where he obtained favour with Riolan. In 1630 he was made a Doctor at Wittenberg, and two years later he became Professor of Medicine at Ro* stock. In 1639 he was called to Den* mark, where he was appointed Professor Extraordinarius of Anatomy, Surgery and Botany at the University of Copen* hagen. In 1645 he inaugurated the first Danish Theatrum Anatomicum, being the first Professor of Anatomy in his adopted country. However, he was not much interested in this branch of science, and in 1648 he resigned his professor* ship to Thomas Bartholin, in order to devote himself to the study of botany which he cultivated in several ways, for instance by making botanical excur* sions with his students. In 1650 Paulli became Physician to the Royal House* hold; in 1656 he was appointed Physi* cian in Ordinary to the King; besides he obtained a Canonicate and later on a Prelature in Aarhus in Jutland (Den* mark). His most important contribution to literature is his work Flora Danica (1648). See Dansk biografisk Lexikon, NOTES 241 vol. XII p. 567. (Jul. Petersen, E. Ro= strup). P. 77. 1. 5 from top. D. GEORGIO HILARIO]/0r= gen Eilersen, Georgius Hilarius (1616— 1686) was born at Vordingborg in Den* mark and from 1635 to 1638 studied at the University of Copenhagen, where he graduated in theology. After that he went abroad for some time, returned and lived as a vicar in the country till 1641, when he was appointed assistant master at Vor Fvue Skole (Our Lady's School) in Copenhagen, graduating in the same year as Master of Arts. In 1654 he was appointed Titular Professor at the University, and in 1672 he became Professor Ordinarius of Mathematics. He had been Steno's teacher, when the latter went to school at Our Lady's. See Dansk biografisk Lexikon, vol. IV p. 464 (S. M. Gjellevup). P. 79. 1. 10 from top. Stevinus] SzmonSfeWn (1548-1620) an eminent mathematician and mecha* nician, who contributed largely to the foundation of the science of statics. (Biogr. Woordenboek der Nederlanden, vol. XVII 2. p. 1003 and Biographie UnU verselle, vol. LI p. 237.) In Les CEuvres Mathematiques De Simon Stevin de Bruges . . . Par Albert Girard. A Leyde 1634. J Livre de la Geographie. p. 110 Stevinus, in continuance of and relative to a long Letter written by Hugo Grotius, discourses on the praise of previous scientific contributions, contained in the works of certain classical authors. P. 79. 1. 23 from top. Crifpini famam] See Horatius, Sermones, I 1, 120. ne me Crispini sainia lippi compilasse putes. Porphyrius says in his commentary: Plotius Crispinus philosophise studiosus fuit. Idem et carmina scripsit, sed tarn garrula, ut aretalogus diceretur. P. 79. 1. 24 from top. hunc foe turn] Ed. Lugd. Batav. 1662 has hunc factum. P. 82. 1. 11-12 from top. Whartono innominata dicta] See Adenographia . . . Authore Thoma Whartono. Londini 1656. c.XXVI pp. 176—187. Wharton, as was common in those days, described a glanduia lacry= malis and a glanduia innominata. The former is situated in the inner canthus of the orbit and in many mammals is actually a lachrymal gland, correspond ding to the caruncula lacrymalis in man. The latter, glanduia innominata, is situa* ted in the lateral part of the orbit and is the one now called the lachrymal gland. — Wharton, having discussed the various theories concerning the secretion of tears (p. 178) gives his own view (pp. 181-182). P. 182: Certumeft, cerebrum in maerore contrahi; &- contractum, alu quid exprimere; cumqve materia tenuior, facta comprejjione, faciliiis exiliat quam craffior; fit, ut ea fie exprejfa valde tenuis fit, apteq; lachrymarum formam fufcipiat. According to Wharton, the tears pass along the nerves into the eye, out of which they pass through minute pores. He does not believe tears to be secreted from his glanduia lacrymalis (carunculus lacrymalis), but still he adds (p. 182): non tamen plane nego, quin aliquae cerebri humiditates per banc par- tem evacuentur. About the function of his glanduia innominata (glanduia lacry- 242 NOTES malis) he says (p. 183): Ufus hujus glandula? propemodum coincidit ciim priore . . . , et ha?c quoque humiditates quafdam, quanquam non totam lachry= marum materiam, ocu/o/Iippec/ifaf. While Steno maintains that glandula innomh nata secretes the tears, he does not ob* ject to glandula lacrymalis being a gland, and perhaps he tacitly takes it for granted that its function is, also, that of secreting lachrymal fluid. Observe that the exa* minations of Wharton and Steno were made on animals, not on man. Besides, Steno was the first to prove that the upper and lower lachrymal ducts are the channels, along which the tears are conveyed to the cavity of the nose. P. 82. 1. 12-13 from top. conglomeratarum . . . munus] On Sylvius's classification of the glands, see note to vol. I p. 20. 1. 17-18 from bot* torn. P. 82. 1. 1 1 from bottom. Platerus meminit] See Felicis Pla= teri . . . Praxeos Seu de cognofcendis, prsedicendis, prsecauendis, curandisq ; af= fectibus homini incommodantibus Trac= tatvs I-III. Basilese 1608-1609. vol. Ill sect. 2. c. VII p. 734. P. 85. 1. 18-19 from top. Platerus ftatuit] Ibid. p. 737 and following pages. P. 85. 1. 14 from bottom. Veflingius putat] See Ioannis Ves= lingii . . . Syntagma Anatomicvm, Loci's plurimis auctum, emendatum, nouifque iconibus diligenter exornatum. Patavii 1647. c. XV p. 198: Vnde igitur liquor ille, inquies, in dolore tarn foscundus, tarn paralus? Non ab ipjis fane oculis, fed a cerebro, per fecundum cuneiform mis ofjfis foramen, turn a vertice capitis ac lateribus ad punctorum propqfitorum ductus confluit. This passage is not found in Ed. Francofurti 1641 nor, as is most likely, in the original edition (Patavium 1641). — Secundum cuneiformis ossis foramen is the fissura sphenoidalis os= sis sphenoidei. — See Syntagm. Anat. Ta« bvlae Cap. XIII Declaratio.p. 167 and fig. V on p. 169. P. 85. 1. 11 from bottom. Clariff. Schneiderus] A very ela= borate account of the various theories concerning the process of secretion of tears is to be found in Conradi Vic= toris Schneideri . . . Liber De Catarrhis Tertius . . . Wittebergae 1661. See p. 329. Schneider's own view is spoken of on p. 501 and the following pages. See note to vol. I p. 28. 1. 4 from top. P. 85. 1. 10-11 from bottom. Ingeniofiffimus Cartefius] See Les Passions De L'Ame. Par Rene Des Cartes. A Paris 1649. Article CXXVIII p. 169: Et pour bien entendre leur ori= gine, il faut remarquer que bien qu'il forte continuellement quantite de vapeurs de toutes les parties de noftre corps, il n'y en a toutefois aucune dont il en forte tant que des yeux, a caufe de la gran= deur des nerfs optiques, &■ de la multi- tude des petites arteres par oit elles y vien[n]ent; Et que comme la fueur n'ejl compofee que des vapeurs, qui fortant des autres parties fe convertijfent en eau fur leur fuperficie, ainji les larmes fe font des vapeurs quifortent des yeux. P. 86. 1. 3 from top. Wharton. Adenogr. c. 26] pp. 178-179. NOTES 243 P. 89. 1. 8 from top. oculos erudiere] Ovidius, Remedia Amoris, 689-690: Neve puellarum lacrymis moveare caveto: Ut flerent, oculos erudiere suos. P. 89. 1. 16 from bottom. juxta illud Ovidii] Ars amandi I 661-662. P. 90. 1. 12 from top. Clariff. Bartholinus] See Thom.de Bartholini Historiarum Anatomicarum Rariorum Centuria let II. Hafniae 1654. Cent. II Hist. XCVII p. 345. P. 90. 1. 1-2 from bottom. glandulae . . . fudorem produ* cant] See Letter from Steno to Th. Bartholin in Epist. Medicin. Cent. III. Hafnise 1667. Epist. LXV p. 263. It is found as No. VII in the present Edi« tion, vol. I p. 101. VI DE NARIUM VASIS. This Treatise must have been com* posed in December 1661, being written as an appendix to the preceding one, De Glandulis Oculorum, which bears the date of December 6, 1661, and to* gether with which it appeared in print about New*Year 1662, as the last of the four Treatises in Nicolai Stenonis Observationes Anatomical . . . Lugd. Batav. 1662. P. 93 1. 6-7 from bottom. Libr. de Cam. 7 Hippocrates, De Carnibus (Hep! dpxcov f\ odpxcov) 16. Ed. Littre. vol. VIII p. 604. P. 94. 1. 12-13 from top. aqvae ductum] Aqvae ductus is now called Tuba Eustachii. P. 94. 1. 13-14 from top. tunica* Schneidero pituitarise ap= pellatae] See note to vol. I p. 28. 1. 4 from top and p. 69. 1. 1 1 from bottom. P. 94. 1. 13 from bottom. Veflingius exiftimat] See Ioannis Veslingii . . . Syntagma Anatomicvm . . . Patavii 1647. c. XV p. 197: Recumbit in eo [sc. cantho interno] Caruncula fpongiofa, &■ mollis, meatum fubiecti ojjis, qui ad nares pertingit, operiens, utfluxum per eas lacrymarum impediai; unde lacrymalis dicta ejl. The last four words are not found in Ed. Francofurti 1641. P. 94. 1. 9-10 from bottom. hujufmodi] Schneider has ejusmodi instead of hujufmodi and in the next line ea foramina instead of hxc fora= mina. P. 94. 1. 2 from bottom. de ocul. part. 1. c. 13] See Hiero= nymi Fabricii Ab Aqvapendente De Visione Voce Avditv. Venetiis 1600. Pars I c. 13. p. 25. P. 95. 1. 2—3 from top. in utroqve angulo] Ed. Venet. has vnoquoq; instead of utroqve. P. 95. 1. 11-12 from top. nervofum] Nervosus was still at that time used in a sense closely correspond ding to what was afterwards called f- brosus. P. 95. 1. 10 from bottom. non raro notavi] The following 244 NOTES description applies to the conglomerate nasal gland, glandula nasalis Stenonis, about which Steno expressly states that it is not found in man. P. 96. 1. 18-19 from bottom. in utravis parte una] The folio* wing description refers to ductus incisivi s. nasopalatini , also called the canales Stenonis after the name of their disco* verer. These ducts are the remainder of the wide aperture between the mouth and the nasal cavity which exists in early fetal life, an aperture which in man closes before birth, whereas it remains in many animals. The Organ of Jacobson, discovered by a country* man of Sfeno, opens into these ducts. P. 96. 1. 9 from bottom. tertii maxillae offis fupercilium] Os tertium maxilla? is what is now cal* led processus nasalis maxillae superioris. P. 97. 1. 6-7 from bottom. KparEEi . . . xovq ttovouc;] Steno possibly has in mind the following pas* sage in Hippocrates, De Epidemiis (TTepi ' Embriuiuv) VI 5, 5 riovoc, roictv dp^poioi xcti dapxi Oiroq, u^voc; cw,\dYXv0l0lv. See Ed. Littre, vol. V p. 316 and note on p. 317. VII SUDORUM ORIGO EX GLAN* DULIS. DE INSERTIONE 5, VAL* VULA LACTEI THORACICI & LYMPHATICORUM. This Letter from Steno to Th. Bar= tholin, dated January 9, 1662 (new style), accompanied the copy of the then just published Observationes Ana= tomicae . . . Lugd. Batav. 1662, sent by Steno to Bartholin. The Letter is found in Th. Bartholini Epist. Medicin. Cent. HI. Hafniae 1667. pp. 262—266, num* bered Epist. LXV. P. 101. 1. 5 from top. a Difputatione] Steno's Disputatio Anatomica De Glandulis Oris . . . Lugd. Batav. 1661, appeared early in July. It was reprinted as the first of the four Treatises in Observationes Anatomicae, published immediately after New*Year 1662. It is found as II in the present Edition, vol. I. p. 9. P. 101. 1. 8 from top. excurfione avocatus] See vol. I p. 55. P. 101. 1. 11 from bottom. Sylvius conglomeratas nominat] See note to vol. I. p. 20. 1. 17—18 from bottom. P. 102. 1. 19-20 from top. a Clariff. Borrichio tibi ilia fig* nificari] The letter from Ole Borch to Th. Bartholin to which .Sfeno refers in this place, bears the same date as Steno's, viz. January 9, 1662. It is found in Th. Bartholini Epist. Medicin. Cent. III. Hafniae 1667. pp. 416—425, numbered Epist. XCVII. P. 102. 1. 17 from bottom. fui occupatus] See vol. I p. 57. 1. 18 from top. P. 102. 1. 1-2 from bottom. D. Blafium . . . fraterqve ejus] See the Introduction and the previous Treatises passim. Concerning Blaes' brother see notes to vol. I p. 4. 1. 15 from top and p. 19. 1. 15 from bottom. NOTES 245 P. 103. 1. 7-8 from top. Magnifico Domino Cancellario] The Danish nobleman Peder Reedtz (1614—1674) was appointed Chancellor of Denmark in 1660. The following year he became Patron of the University of Copenhagen (see Dansk biografisk Lexi= kon, vol. XIII p. 564). — Bartholin en* deavoured to pave the way for the ap* pointment of Steno to a professorship at the University. However, he later on gave up this for the benefit of Matthias Jacobssus. See note on p. 226. VIII CUR NICOTIANS PULVIS OCU* LOS CLARIORES REDDAT. DE LACTEA GELATINA OBSERVA* TIO. This Letter from Steno to Th. Bar= tholin is dated Leyden May 21, 1662. It is found in Thomae Bartholini Epist. Medicin. Cent IV. Hafniae 1667. pp. 1—10, numbered Epist. I. Bartholin's reply of February 14, 1662 (Epist. Medicin. Cent. III. Hafniae 1667. Epist. LXVI) to Steno's Letter of Janu* ary 9 (ibid. p. 262. Vol. I p. 99 in the present Edition) contains, on p. 267, the following request, which occasioned the appearance of this Letter. Tu videris, an ex ductus tui l) cum oculis commer= do copiofus humor ex oculis per nares educatur pulvere nicotianae. Tejlabatur mihi olim illufhris Wormius Confulem Chrijliano Hafnienfem 2) imbecilli vifu laborantem ope talis pulveris optime re= ') i. e. canalis naso=lacrymalis. 2) In 1618 Christian W had founded the town of Christianshavn on the north-west point of the isle of Amager, opposite to Copenhagen. In 1674 it was incorporated with Copenhagen. Jhtutum. Idem in ipfo me expertus fum. Acutius enim multb video objecta remo= tiora pojl ufum pulveris tabaci. P. 107.1. 10-11 from top. placuiffe tibi . . . oftendifti] Con* cerning this, see Bartholin's Letters to Steno of February 14, 1662, in Epist. Medicin. Cent. III. Hafniae 1667. Epist. LXVI p. 266-267, and to Ole Borch, of the same date, ibidem. Epist. XCVIII p. 426. See note to vol. I p. 103. 1. 7-8 from top in the present Edition. P. 108. 1. 9 from top. Qvod D. Blafium fpectat] See note to vol. I p. 102. 1. 1—2 from bot* torn. P. 108. 1. 16 from bottom. Nee Deufingii opprobria mo* ror] See the Introduction and the Trea* tises II, III and especially IV in the present Edition. P. 108. 1. 14 from bottom. Bilfii fautorem] See the Introduc* tion, the note to vol. I p. 6. 1. 1 1 from bottom, and previous Treatises passim. P. 109. 1. 18 from top. in Lilii Gyraldi Dialogis] Lilio Gregorio Giraldi (1479-1552), born in Ferrara, a Protonotary Apostolic, was a good poet and an expert archaeologist. The first complete edition of his works appeared in Basle, 1580; but in this the editor has not been able to find the treatise referred to by Steno; on the other hand, see Lili Gregori Gyraldi. . . Opera Omnia . . . Lvgdvni Batavorvm 1696. vol. II DialogismusVII. Ad Vincentium Madium Philofophum de fafcino &■ fafcinatione. p. 873: Fafcinatio autem 246 NOTES morbus eji, qui ex fpiritu fafcinantis per oculos fafcinati ad cor ipjius ingrejjb pervenit: fpiritus enim cordis a calore ex puriori J anguine generatur. Tales au= tern funt in nobis fpiritus, qualis eji fanguinis humor. Spiritus autem Jimiles Jibi radios per oculos quaji per vitreas fenejhas emittit. Cor enim fuo perpetuo quodam motu proximum Jibi fanguinem agitans ex eo fpiritu, in totum corpus, perque illos luminum fcintillas per mem= bra diffundit quidem Jingula, per oculos autem maxime. Ad altifjimas partes, cum fit leviffimus, maxime evolat fpiritus, ejufque lumen per oculos cum perfpicui maxime &■ nitidi fint, maxime emicat. Nam quod aliquod lumen in oculis fit, patet ex eo, quod quorundam brutorum oculi in tenebris micant. P. 109. I. 18-19 from bottom. Cartefius ... in fuo De Homine Tractatu] In the work in question Descartes has nothing to that effect about the tears. Steno no doubt had in mind what he says in Les Passions De L'Ame, Article CXXVIII. See note to vol. I p. 85. 1. 10 from bottom. P. 109. 1. 10-11 from bottom. detectis novis lacrymarum . . . rivulis] See the Treatise V in the pre* sent Edition, especially vol. I p. 85. 1. 10 from bottom. P. 110. 1. 14 from bottom. in Peireskii Vita Gaffendus] See Viri Illvstris Nicolai Clavdii Fabri* cii De Peiresc . . . Vita, Per Petrvm Gassendvm . . . Parisiis 1641. lib. V p. 280: Animaduertit fi quidem ocu= los fuos Jic excipere imagines rerum, vt afferuarent Mas diutiiis, 6- maxime quidem cum a fomno humefcerent. Sic expertus eji millies, cum refpexiffet in feneflram clathris igneis, quadratulifque papyraceis interJHnctam, cir cumf err efefe deinceps illius for mam in oculis; fed cum eo difcrimine, vt fi claufos quidem contineret, turn clathros obfcuros, &■ quadratula Candida, cuiufmodi confpecta fuerant, videre adhuc videretur. P. 110. 1. 10-11 from bottom. cum Nobil. Gerftorphiis meis] Ole Borch was for five years the tutor of the sons of Joachim Gersdorf, the Lord High Steward of Denmark. When in 1660 he was appointed professor at the University of Copenhagen and went abroad, this connection ceased. In 1661, however, Joachim Gersdorf died, and his sons were sent abroad to be once more in the care of Borch. Steno made their acquaintance in Holland. See Dansk biografisk Lexikon, vol. II p. 501. P. 111. 1. 6 from bottom. cum Rolandi Sturmii . . . tracta* tu] Febrifugi Peruviani Vindiciarum Pars Prior (et Altera) . . . Auctore Ro= lando Sturmio. Delphis 1659. — In this book the author strongly advocates Pe* ruvian bark as a remedy against fevers. The poem in honour of the author, placed at the beginning of the book, cannot be said to exaggerate when it opens with the following eulogy: lam fugiunt Rolande febres, jam pallida cedit Mors tibi, jam vitam fama benigna refert. Quern laudas veteri cortex ex arbore vita; Hie fupereft — IX OBSERVATIONES ANATOMIC/E IN AVIBUS & CUNICULIS. This Letter from Steno to Th. J3ar= NOTES 247 tholin is dated Leyden August 26, 1662. It is found in Thomx Bartholini Epist. Medicin. Cent. IV. Hafniae 1667. pp. 103-113, numbered Epist. XXVI. P. 115. 1. 10 from bottom. De Clariffimo Blafio] On Steno's controversy with Blaes concerning the priority of the discovery of the duct of the parotid gland, see the Introduction, the previous Treatises passim as well as the notes belonging to the latter, and Apologise Prodromus (XIII, vol. I p. 143 in the present Edition). The following part of the Treatise refers to a statement of Bartholin's in a letter to Steno, dated Copenhagen February 14, 1662, which is found in Epist. Medicin. Cent. III. Hafniae 1667. Epist. LXVI pp. 267-268: D. Blafius fufpectum me habet, nullo meo merito, iccircb nuper me purgavi, qvia nollem inter vosjimultates.fperemq; me inter vos reducturum tandem amici- tiam. P. 116. 1. 1 from top. van Home aggreffus fit] As to this, see the Introduction, but especially Steno's Responsio ad Vindicias Hepatis Redivivi (IV vol. I p. 59 in the present Edition); see, moreover, most of the previous Treatises passim. P. 116. 1. 6 from top. apud Lucianum Timon] See Lu= cianus, Ti'ucov 2. P. 116. 1. 12 from top. acceffit etiam Antonius Ever- hard i] See Steno's Disputatio Anato- mica De Glandulis Oris . . . Secunda. Lugd. Batav. 1661 (II vol. I theses 49 —52, pp. 46—49 in the present Edition). To this Everaerts replied in his Lux e Tenebris Affulfa, Ex Vifcerum Monftrqfi Partus Enucleatione Propositaq. Ab An= thonio Everardi . . . Medioburgi 1662. P. 116. 1. 14 from bottom. qvod Hollandicis denegavit] Middelburg is in the province of Zee* land, Leyden in the province of Holland. P. 117. 1. 2 from top. nulla ratione poffem evitare] Th. Bartholin was the discoverer of the lymphatic vessels. See note to vol. I p. 3. 1. 1 from top. P. 117. 1. 7-8 from top. in corvo aqvatico] i. e. Phalacroco= rax carbo (L.). P. 117. 1. 11-12 from bottom. Parens ... in Anatomicis Infti= tutionibus] Casp. Bartholini . . . In= stitvtiones Anatomicae . . . ab Auctoris Filio Thoma Bartholino. Lvg. Batavorvm 1641, lib. I c.XVp. 90 has about duc- tus communis: &■ oblique inferitur inter utramque intejlini tunicam, [digiti longi= tudine] &■ quidem aliquando bifidus . . . The edition of 1641 is the first edition, which was revised by Th. Bartholin. The editor of the present work has not seen the original edition (Wittenberg 161 1). In the oldest reprint from it, that of Rostock 1622, the two words within brackets are not found. P. 118. 1. 10 from top. ex Harveei fententia] See Exerci= tationes De Generatione Animalium . . . Autore Gvilielmo Harveo . . . Londini 1651. Exercit. 6. p. 21: infra jecur ven= triculus pqfitus eft; cui fubjacent inte= ftinorum volumina, cum plurimis tenui= bus membranis interjectis, aere repletis; 248 NOTES quippe in has, ut diximus, afperae puU monum arteriae foraminibus hiulcis ape= riuntur. P. 118. 1. 17 from top. cum Celeberrimo Pifone] Willem Piso (1611—1678), who was born in Leyden, took his doctor's degree in Caen in 1630, and in 1637 he became Physi* cian in Ordinary to Count Joan Mau= rits of Nassau. He took part in a long journey to Brazil, and, from 1648 until his death, he lived as a physician in Am* sterdam. Among other works he is the author of De Medicina Brasiliensi Libri Qvatvor . . . Lvgdvn. Batavorvm et Am= stelodami 1648 and De India? Utriusque Re Naturali Et Medica Libri Qvatvor* decim . . . Amstelaedami 1658. See Biogr. Woordenboek der Nederlanden, vol. XV p. 332 and Biographiscb.es Lexikon der hervorrag. Aerzte von E. Gurlt, vol. IV p. 577. P. 118. 1. 18 from top. Dn. Gottwaldo] Cristoph Gottwaldt (1636—1700) was a learned physician and scientist from Dantzic (Gedanum). He was made a doctor in Leyden 1662. See Biographisches Lexikon der her= vorrag. Aerzte von E. Gurlt, vol. II p. 609. P. 120. 1. 13 from top. Cartefii Tractatus de Homine] Renatus Des Cartes De Homine Figvris Et Latinitate Donatus AFlorentio Schuyl, Inclytae Urbis Sylvae Ducis Senatore, &■ ibidem Philofophiae Profejfore. Lvgdvni Batavorum 1662. The French original appeared two years later. — Sylva Ducis is the Dutch s'Hertogenbosch. X ex variorum animalium sectionibus hinc inde fao tis excerpts observation nes circa motum cordis auricularumqve & vena: cava:. The observations mentioned in this Treatise are either identical with those mentioned in the previous Letter to Th. Bartholin (IX, vol. I p. 113 in the pre* sent Edition) or they are closely con* nected with the latter, being in all pro* bability made almost at the same time, i. e. in Leyden in 1662. The text itself practically only consists of brief notes on each observation, and Steno has made no attempt to work them up into a whole; no doubt they were meant to form part of an exhaustive study on animal motion or more especially on the motion of the heart, which work, however, he never accomplished. The very last part of the Treatise, from Pof= fent inde alia (p. 127. 1. 9 from top) to the end, in language as well as in contents, differs from the other part, and has certainly been added by Steno at a far later period, viz. when from 1672 till 1674 he was Anatomicus Regius in Copenhagen and left the Treatise in the hands of Bartholin to be published by him in Acta Medica Et Philosophica Hafniensia, where it is found in vol. II, 1675, as No. XXXXVI p. 141. P. 124. 1. 9 from top. repetitis] Acta Hafn. has repetitus. P. 124. 1. 11 from top. & arteriae ductus] Acta Hafn. has ex arteriae ductus. NOTES 249 P. 126. 1. 1 from top. In corvo aqvatico] See note to vol. I p. 117. 1. 7-8 from top. P. 127. 1. 1 from bottom. Stultitia caruiffe] Horatius, Eph stolee, I 1, 41-42. XI DE VESICULIS IN PULMONE. ANATOME CUNICULI PRAv GNANTIS. IN PULMONIBUS EX, PERIMENTA. DE LACTEIS MAM, MARUM. IN CYGNO OBSERVA, TIONES &C. This Letter from Steno to Th. Bar= tholin, dated Leyden March 5, 1663, is found in Thorns Bartholini Epist. Me= dicin. Cent. IV Hafniae 1667. pp. 348 —359, numbered Epist. LV. P. 131. 1. 4 from top. binis . . . beatus litteris] Only one of these letters is known, viz. the one found in Epist. Medicin. Cent. IV. p. 1 1 3, numbered Epist. XXVII, dated Copen, hagen September 7, 1662. P. 131. 1. 9 from top. De . . . Malpighii obfervationi* bus] The results of Malpighi's exami* nations of the structure of the lung, together with his demonstration of the existence of small vesiculx in the latter, were published for the first time in De Pulmonibus Epistolae II ad Borellium, Bononiae 1661. In his above-mentioned Letter to Steno, Bartholin had spoken of these observations of Malpighi's and called upon him to further examine the question. Bartholin had also written to Ole Borch and van Home about it, and in 1663 he reprinted Malpighi's Letters in Copenhagen: Thomse Bartholini De Pulmonum Subjlantia 6- Motu Diatribe. Accedunt CI. V. Marcelli Malpighij de Pulmonibus Obfervationes Anatomicx. Hafniae 1663. P. 132. 1. 4-5 from bottom. Dominus Swammerdamius] Jo= annes Swammerdam (1637— 1680), born in Amsterdam, was the son of a chemist of that town, who was intensely interest- ed in curiosities of art and nature. In Amsterdam young Swammerdam began to study medicine, especially anatomy, under Blaes and Tulp. At this early period he made the acquaintance of Steno, which acquaintance soon ripened into friendship. Afterwards they both studied in Leyden, under Sylvius and van Home, and here the two students made many joint investigations, which co-operation, as mentioned in the Intro, duction, was later on continued at The= venot's in Paris and Issy. In 1665 Swam= merdam was once more in Amsterdam, and in 1666 he was in Leyden, where in the following year he was made a doctor. In spite of splendid offers from abroad Swammerdam preferred to stay in Holland. He went to live in Amster, dam, where he lead a retired life in the house of his father, but religious scrup, les gradually got the upper hand of his otherwise clear intellect; he gave up his scientific studies, and especially after he had came under the influence of Antoin= ette Bourignon his mind gave way al, together. — Swammerdam made many valuable anatomical and physiological discoveries; but his name is chiefly asso* ciated with the study of insects and their biology, a branch of science which he was not only the first to cultivate, but 250 NOTES which he also enriched with numerous excellent observations. The manuscript of his chief work, which was for a long time looked upon as lost, was found many years after his death and was edited in Dutch and Latin by Boerhave: Jo- annis Swammerdammii . . . Biblia Na= turae; Sive Historia Insectorum . . . Ley* dae 1737—1738. See, besides, Biogr. Woordenboek dev Nederlanden , vol. XVII 2 p. 1095. The experiment mentioned in the text, is spoken of in Johannis SwammerdamI . . . Tractatus PhyJico=Anatomico=Me= dicus De Respiratione Ufuque Pulmo= num. Lugduni Batavorum 1667. c. Ill p. 19 ff., but it had already been men* tioned before by Sylvius in the Addi* tamentum to his dissertation De Respi= vatione, Usuque Pulmonum, which ap* pears as No. VIII in Disputationum Medicarum Pars Prima . . . Amstelodami 1663. See § 79 p. 126 and § 86 p. 131. P. 133. 1. 2 from top. apud Dn. Padbrugium] Epist. Me= dicin. Cent. IV. has Padburgium. — Rob. Padbrugge, a physician, published De Apoplexia. Lugd. Batav. 1663. (See Jo= ckers Gelehrten=Lexikon, Fortsetz. v. Ro= fermund. vol. V. Bremen 1816.col. 1370). — Swammerdam's Tractatus . . . De Re= spiratione Ufuque Pulmonum has feet. II c. II p. 77: Conjiderandum itaque Primo. Quod Sanguis in Infpiratione (a Dia= phragmatefe contrahente, atque abdomU nis vifcera deorfum, introrfum, ac extror* fum cogente; ut & a Thorace furfum mo= to, Aeremquejimul cum Diaphragmate in corporis circumjectas partes atque PuU mones propellente & impellente) e Venis Corporis tarn Superioribus quam Inferio* ribus diverfus ac copiojiorfolito, in Pectus atque Cor verjus moveatur: ut oblervatum ab Amico noftro D. Padtbrugge in Corol* lariis Thefium Inauguralium Lugd. Bat. habitarum anno 1662. P. 133. 1. 3-4 from top. ab ingeniofiffimo Dn. La br] Epist. Medicin. Cent. IV. has Dn. Laer. — HaU ler, Bibliotheca Anatomica I p. 717 men* tions P. v. der Lahr as the author of De fermentatione, effervefcentiis &■ infiam= matione. Leid. 1685. See also Epist. Me= dicin. Cent. IV. Epist. LXX pp. 418- 419 (XIV vol. I p. 159. 1. 11 from bot* torn in the present Edition). P. 133. 1. 7 from bottom. Sane Schenckium nil vidiffe] See Ioh. Theod. Schenckii . . . Exercitationes Anatomica? Ad Vsvm Medicvm Accom= modatse. Ienae 1662. — When Steno here speaks of Schenck, and when a little further on he mentions the diffe* rent ways in which the chyle, by various anatomists, was supposed to be con* veyed direct to the mammae, he does so referring to the following passage in Th. Bartholin's Letter of September 7, 1662, Epist. Medicin. Cent. IV. Epist. XXVII p. 114: Lacteas qvasdam ad mamillas recta furfum tendere vidit Jo. Theod. Schenckius /. /. Exerc. Anat. 7. Sect. 2. c. 32. Sed talem furculum feu canaliculum lacteum ex thoracico ad mufculos thoracis, &■ exinde ad ipfa ube= ra furtim ferpere obfervavit Pecqvetus Exper. IV. contra Riolanum. De ramu= lis qvibusdam ad uterum qvoq; Deufin* gius in In/l. Anat. monet. P. 134. 1. 15 from top. fupra abdominis mufculos eo» dem] See Novus Et Genuinus Hominis Brutique Animalis Exortus. AuthoreAn? thonio Everardi. Mediobvrgi 1 66 1 . p. 1 3 3. NOTES 251 P. 134. 1. 16-17 from bottom. in refponfione ad Everhardum] This reply never appeared. See, besides, the previous Treatises passim. P. 134. 1. 13 from bottom. lymphaticorum tuorum . . . veri* tas] Refers to Bartholin's discovery of the lymphatic vessels. See notes to vol. I p. 3. 1. 1 from top, p. 6. 1. 16 from bottom and p. 21. 1. 1 from top. P. 134. 1. 10-11 from bottom. hepati jungi dixi] Se IX, vol. I p. 117. — Bartholin dwelt on the obscurity of this passage in his reply, which is found in Epist. Median. Cent. IV. as Epist. XXVII. See p. 115. P. 134. 1. 4 from bottom. M. A. Severini obfervatio] In his Letter to Steno, Epist. Medicin. Cent. IV Epist. XXVII p. 115, Bartholin re, ferred to Zootomia Democritaea : Id eft Anatome Generalis totius animantium Opificii . . . Marci Aurelii Severini. No< ribergae 1645. pars IV p. 340, which has: Jecur pauco, aut fere nullo inter= vallo diftans a corde, quod quidem parte pofteriore quaji per cifternae os vafa excipit. P. 135. 1. 4-5 from top. tractatulum curabo edendum] Steno 's De Musculis &■ Glandulis oh= fervationum fpecimen (XV vol. I p. 161 in the present Edition) appeared in Co* penhagen in 1664. It contains several remarks referring to the controversies just mentioned; but a proper reply to Everaerts and Deusing never ap« peared. Steno replied to Blaes in Apo= logiae Prodromus . . . Lugd. Batav. 1663 (XIII vol. I p. 143 in the present Edition), caused by Hoboken's Novus Ductus Salivalis Blasianus . . . Ultra* jecti 1662. — See, moreover, Steno's next Letter to Bartholin, found in Epist. Medicin. Cent. IV as Epist. LXX pp. 414-421. (XIV vol. I p. 155 in the present Edition.) P. 135. 1. 18-19 from top. numerum lemper obfervavi eun* dem] See IX vol. I p. 117. P. 135. I. 9 from bottom. diaphragmatis...abfentiam fup» plentes] Harvey states that birds have no diaphragm. See Exercitationes De Generatione Animalium . . . Autore Gvi= lielmo Harveo . . . Londini 1651. Exer* cit. 6. p. 21 and note to IX vol. I p. 118. 1. 10 from top. P. 135. 1. 2-3 from bottom. de glandula vero lacrymali dic» ta] See note to vol. I p. 82. 1. 11-12 from top. P. 136. 1. 1 from top. in ventriculo nobili] Ventriculus nobilis is what is now called the Fourth Ventricle. P. 136. 1. 4 from top. colorem . . . interius cineritiumj Epist. Medicin. Cent. IV. has cineritiam instead of cineritium. — The pineal gland, as is mentioned above, in certain animals exhibits this very distribution of colour; in the horse, for instance, the cells contain yellow and black pigment. As to Bartholin's opinion of Steno's observation, see his reply to the latter, in Epist. Medicin. Cent. IV. Epist. LVI p. 360. 252 NOTES P. 136. 1. 11-12 from top. a Nobiliff. Cartefio excogitata fa brie a] See note to vol. I p. 120. 1. 13 from top and Steno's Discovrs Svr L' Anatomie Dv Cerveav, which was de= livered in Paris in 1665 (XVIII vol. II p. 1 in the present Edition). XII LYMPHATICORUM VARIETAS. The investigations, on which this Trea« rise is based, were most likely made by Steno in collaboration with Swammer* dam, some time in the years of 1662 and 1663; one of the drawings is likewise due to Swammevdam (see the Treatise). Steno had planned an exhaustive work on the lymphatic system, but never rea» lized his plan. The text of this Treatise is, at any rate as far as the latter part is concerned, no doubt composed long after the time when the investigations were made, probably during Steno's stay in Copenhagen in 1672—1674. TheTrea* tise appeared in Thomse Bartholini Acta Medica Et Philosophica Hafniensia. vol. II Hafniae 1675 as No. XCVII pp. 240 -241. XIII APOLOGIAS PRODROMUS, QVO DEMONSTRATOR, JUDICEM BLASIANUM G, REI ANATOMICAL IMPERITUM ESSE, & AFFECTU* UM SUORUM SERVUM. This Tract is the last of Steno's writings relative to his controversy with Blaes about the priority of the discovery of the parotid duct; concerning this con* troversy see the Introduction and the previous Treatises passim. This pam= phlet was caused by a little book, with the title of Novus Ductus Salivalis Bla= sianus, In lucem protractus A M. Nico= lao Hoboken, Ultrajectino, Philofophiae & Medicines Doctore ac Practice Ul« trajecti 1662, which Nicolaas Hoboken (1632—1678), a young friend of Blaes, published in his defence. In his pamphlet Hoboken stood forth as a judge in the quarrel between the two men. The judg* ment he pronounced was entirely in favour of Blaes; a decision at which he arrived all the more easily, as he did not enter into any investigations of his own in the matter in question. Hobo= ken's pamphlet consists of a preface, written by himself; an anagram on Ste= no's name (see below); a letter from Hoboken to Blaes; a letter from Blaes to Hoboken; three testimonials from former pupils of Blaes; a letter from Blaes to Th. Bartholin, dated Amster* dam July 16, 1661 (reprinted in Thomse Bartholini Epist. Medicin. Cent. HI. Hafnia; 1667. Epist. XLIII pp. 158- 184); and last a letter from Hoboken to Blaes. About Hoboken, see Biogr. Woordenboekder Nederlanden, vol. VIII 2 p. 841. P. 145. 1. 6-7 from top. Ductus Salivalis] Hoboken has Ductus illius Salivalis. P. 145. 1. 12 from bottom. in ipfa Apologia] The Apology iU self never appeared, as a reconcilement between Steno and Blaes took place before that time. P. 145. 1. 1 1 from bottom. me infelici puero comparando] Hoboken has (p. 38): Infelix puer atqve impar congreffus Achillil NOTES 253 P. 145. 1. 5 from bottom. Verba in qvibus] The following passage is a somewhat condensed quo* tation from Hoboken's last letter to Blaes. See Hoboken's pamphlet p. 55 ff. P. 146. 1. 3-4 from top. Anagrammate publice procla* mat] The anagram runs as follows: Super inventione ductus Salivalis. STENONIS. Per Anagrammatifmum, IS NON EST. SI NON EST, SINON EST. ANne Salivalem, ductufque invenerit ufum BLASIUS; anne prior tale Stenonis opus? Infpice STENONIS nomen, converte; videbis, llle quod IS NON EST, qui effe Stenonis amat. Ex re nomen habet. Quod si turn, candide Lector, Stenonis NON EST jure repertor: age, BLASIUS, ut fas est, DUCTUM inveniffe SA° Dicatur PRIMUS; nee prior ullus eo. [LIVAi BLASIUS inventor pxoflet, non ille Stenonis; Fallax rite SINON1) nomine quippefuo EST. 2) Proditor Trojanus. P. 146. 1. 7 from top. in Obfervationibus Anatomicis] Nicolai Stenonis Observations Anato= micae. . . Lugd.Batav. 1662. It is the first of the four Treatises in the book in question and had already been published in the previous year under the title of Disputatio Anatomica De Glandulis Oris . . . Prima (&■ Secunda). Lugd. Batav. 1661 (6—9 July). The parotid duct, however, had been mentioned still earlier by Steno in a Letter to Th. Bartholin, dated April 22, 1661. See I and II in the present Edition. P. 146. 1. 14 from top. th. 13.] The original Paper has th. V. P. 146. 1. 16 from top. Praeceptores meos] van Home and Sylvius. See notes to vol. I p. 4. 1. 4—5 from top. P. 146. 1. 14 from bottom. a fe inventum proclamat] See note to vol. I p. 4. 1. 12-13 from top. P. 146. 1. 8 from bottom. Muidae] Muiden, a town in the pro* vince of North Holland. P. 146. 1. 1 from bottom. Qyod fi Blafius ... in libro] See Gerardi Blafii . . . Medicina Generalis. Amstelaedami 1661. P. 147. 1. 6 from top. ufui alii ignobili deftinat] See II vol. I § 17. p. 25 and Medicina Gene= ralis, c. XIII p. 24. P. 147. 1. 12 from bottom. a Blafio petierit Bartholinus] Steno, when he went to Holland, had a letter of introduction from Th. Bar= tholin to his relative, Blaes, who re* ceived Steno in his house. See the In* troduction. P. 147. 1. 7 from bottom. Dn. Backmeiftero] Joh. Bacmei- ster, M. D. and Professor of Medicine at Rostock, son of Matthaeus Bacmeister, edited in Amsterdam, 1663, Franz Joel's Opera Medica, in the first edition of which his father had already been en* gaged. See Johannis Molleri Cimbria Literata. Havniae 1744. vol. II p. 50. P. 148. 1. 12-13 from top. dicat Whartonus] See Adenogra- phia . . . Author e Thoma Whartono. Londini 1656. c. XXI p. 128 and c. XX p. 124. 254 NOTES P. 148. 1. 14-15 from top. diftinctio Sylviana] See note to vol. I p. 20. 1. 17-18 from bottom. P. 149. 1. 17 from top. In difputatione] Disputatio de TtU plici Coctione Prima, thes. X : . . qvo= rum [o: ductuum] unus ad maxillae fu= periods latus excurrit, alter ad inferioris extremitatem , circa menti interiora, ad latus fraenuli lingvae . . . (quoted from Blaes' quotation in his Letter to Th. Bartholin, Epist. Medicin. Cent. HI. Hafniae 1667. Epist. XLIII p. 171.). P. 149. 1. 16 from bottom. mentionem facit egreffus ad buc* cas] The Letter mentioned in the note to p. 149. 1. 17 from top contains, on p. 177, the following passage: Nee ta= men volumus falivam non niji per fora* mina ea qvorum unum in qvovis ductu datur, amplumfatis, papillari excrefcen* tia munitum, in oris cavitatem, exire, . . . P. 149. 1. 12 from bottom. nempe 8. Jul.] Steno's first and se* cond Dissertations are dated July 6 and 9. The Letter from Blaes to Bartholin bears the date of July 16, 1661. P. 149. 1. 3 from bottom. p. 35.] The original Paper has p. 45. P. 150. 1. 8-9 from top. rem effe facilis indaginis] Blaes has rem facilis effe indaginis. P. 151. 1. 9 from bottom. Prudentior . . . Vefpa erat] See Phaedrus ed. L. Miiller. Lipsiae 1877. Ill 13. P. 152. 1. 10 from bottom. conglomeratas parotides] Steno calls the parotid gland parotis conglo- merata, and a lymphatic gland imbed* ded in the parotid gland parotis con* globata. See vol. I § 10. p. 22. P. 154. 1. 6 from top. oculis exponeret] The original Pa* per has oculis exneret and po has been added with ink in the only copy of the Paper, which the editor of the present Edition has seen (in The Library of the British Museum). P. 154. 1. 6-7 from top. affectuum fu or um] The original Paper has affectum fuorum. XIV NOVA MUSCULORUM 6, COR* DIS FABRICA. This Letter from Steno to Th. Bar- tholin is dated Leyden ult. April, 1663. It is found in Thomae Bartholini Epist. Medicin. Cent. IV. Hafhiae 1667. pp. 414-421, numbered Epist. LXX. P. 157. 1. 2 from top. APOLOGIAS Prodromum] XIII vol. I p. 143 in the present Edition. P. 157. 1. 2 from top. Nicolao Kragio] Niels Krag is chiefly known on account of his con* troversy with the University of Copen* hagen, which controversy was about payment for services rendered during the time of the siege. In 1667 he was made rector at Ouro, where he died in 1680. He was closely connected with the family of Sfeno's, and the sister of the latter, Anna Kitzerow, stood god* mother to one of his children. See NOTES 255 Kirkehistoriske Samlinger, series III vol.V. Kjobenhavn 1884-86. p. 315. (Holger F. Rerdam.) P. 157. 1. 5 from top. exemplaria qvaedam accepi] Syl= vii . . . Disputationum Medicarum Pars Prima . . . Amstelodami 1663. This edi* tion contains eight dissertations. The two dissertations of Sylvius' De Febribus are found as Nos. IX and X in the next edition. P. 157. 1. 10-11 from top. me . . . abfoluturum] Steno's De Musculis & Glandulis obfervationum Jpecimen appeared in 1664, his Elemen- torvm Myologiae Specimen in 1667, followed by Hiftoria Mufculorum Aqui- Ix in 1675. See XV vol. I p. 161, XXII vol. II p. 61 and XXXII vol. II p. 257 in the present Edition. P. 157. 1. 7 from bottom. nervofam] See note to vol. I p. 95 1. 11—12 from top. P. 158. 1. 1 from bottom. ut Vefalius defcribit] SeeAndreae Vesalii . . . de Humani corporis fabrica Libri feptem. Basileae 1543. lib. VI c. X p. 587. P. 159. 1. 8-9 from top. in Anat tua Reformat.] Thomae Bartholini Casp. F. Anatomia, Ex Cas= pari Bartholini Parentis Institutionibus, Omniumque Recentiorum &■ propriis Ob= servationibiis Tertiiim ad sanguinis Cir- culationem Reformata Cum Iconibus novis accuratissimis. Lugd. Batav. 1651. P. 159. 1. 13 from bottom. a te litteras] See Epist. Medicin. Cent IV Hafniae 1667. Epist. LVI pp. 359-363, dated April 7, 1663. P. 159. 1. 9 from bottom. & Beckero] Perhaps identical with the Becker who in Haller's Bibliotheca Anatomica vol. I p. 707 is called Daniel. Chrijlophori Becker, where he is men* tioned as the author of De Refpiratione. Utrecht 1684. See, besides, the notes to vol. I p. 133. 1. 2 and 1. 4 from top. P. 159. 1. 7-8 from bottom. compreffionem vicinarum parti* um] See Th. Bartholin's letter £pi'sf. Medicin. Cent. IV Epist. LVI p. 359. P. 160. 1. 17-18 from bottom. D. Hobokium . . . mififfe litte* ras, miror] See the introduction to the notes to Apologia? Prodromus (XIII in the present Edition). P. 160. 1. 8 from bottom. aperire licuit uteros] See Th.Bar= tholin's Letter Epist. Medicin. Cent. IV Epist. LXI pp. 360-361. P. 160. 1. 7 from bottom. promiffa Diatribe] Thomas Bar= tholini De Pulmonum Subjlantia &■ Motu Diatribe. Accedunt CI. V. Marcelli MaU pighij dePulmonibus Obfervationes Ana= tomicae. Hafniae 1663. XV DE MUSCULIS £, GLANDULIS OBSERVATIONUM SPECIMEN. Nicolai Stenonis De Musculis S- Glan= dulis obfervationum fpecimen Cum Epi= Jlolis duabus Anatomicis, Hafniae 1664, appeared in the same year in Amsterdam and was reprinted in Ley den in 1683. The investigations, on which the first Treatise is based, were made in Holland 256 NOTES in the immediately preceding years (1661—1663). Compare previous Trea* tises. P. 167. 1. 6-7 from top. publicae luci . . . expofiturum] See Steno's Letter to Th.Bartholin, dated Leyden ult. April, 1663 (XIV vol. I p. 155 in the present Edition). P. 168. 1. 15-16 from bottom. ad aliqvod tempus revertendi] About the time of the death of Steno's stepfather, Johan Stichman (November 1663), his mother was taken ill, for which reason he left Holland in the spring of 1664. His mother died shortly after his return to Copenhagen. P. 169. 1. 3 from top. Adminiftrat. Anatom. 1. 7. § 8] Galeni De Anatomicis Administration^ bus Libri Novem. Sfeno has, erroneously, /. 7. § 9. P. 169. 1. 6 from top. de thorace 1. 1. cap. 8] See Casp. Hofmanni De Thorace, Ejusque Parti= bus Commentarius Tripartitus. Franco* fvrti 1627. lib. I c. 8. p. 13. He adds: Nervi enim dant motum animalem, qualis heic non eft. P. 169. 1. 15-16 from top. cor mufculum pronuntiant] See Hippocrates, De Corde (Hepi Kapbiqc:) 4. Ed. Littre. vol. IX p. 82 . . . n, xapbfn. (jOq £cm xdpra icxupoq, ou rep veupep, dXAd niXfiuari Gapxoq. P. 169. 1. 19 from bottom. D. Harvazus] See Exercitatio Ana= tomica De Motv Cordis Et Sangvinis In Animalibvs, Gvilielmi Harvei . . . Fran* cofvrti 1628. c. II p. 22: Ex his mini videbatur manifeftum; Motum cordis ejje tentionem quandam ex omni parte, &■ fecundum ductum omnium fibrarum, 6- conjhictionem vndique, quoniam erigi, vigorari, minorari, &■ durefcere in omni motu videtur, ipfiufque motum ejffe, qua- lem mufculoru, dum contractio fit fe= cundum ductum partium neruofarum, &■ fibrarum, mufculi enim cum mouentur, &■ in actu funt vigorantur, tenduntur, ex mollibus durifiunt, attolluntur, incraf= fantur, &fimiliter Cor. See, also, ibidem p. 23. 1. 13 from bottom : . . &■ dum tenduntur fibrx . . . P. 169. 1. 19 from bottom. D. Sylvius] On Sylvius' conception of the function of the heart, see e. g. his dissertation De Chyli Mutatione in Sanguinem, Circulari Sanguinis Motu, &■ Cordis, Arteriarumque Pulfu [1659], which, as Disputatio III, constitutes pp. 23—38 of . . . Sylvii . . . Disputationum Medicarum Pars Prima . . . Amstelodami 1663. For instance § 9. p. 26: In cordis ventriculo Jinijho accenditur iteratb &■ rarefit Sanguis ab eodem Igne Cordis inferno, accipitque tunc ultimam fui ab Ipfo perfectionem. And § 16. p. 29: Na* turalem proinde putamus vocandam Cor= dis Ventriculorum Dilatationem, a San= guine rarefcente factam, uti Animalem eorundem Contractionem per mufculos abfolutam, &■ Voluntati quodammodo parentem. And § 33. p. 34: Contrahi verb a Spiritibus animalibus parenchyma ip- fius mufculofum animali motu cientibus. P. 170. 1. 6 from top. Spigelius] See . . . ^4cfn'ani Spigelii . . . De Hvmani Corporis Fabrica Libri Decern . . . Francofvrti 1632. lib. IV p. 134: Initium autem habent [sc. musculi NOTES 257 intercostales externi] primum a tranfuer* /is vertebrarum procejjibus, quibus cq/las fuo capitulo adnecti diximus. The ori« ginal edition is from Venice, 1627. P. 172. 1. 9 from bottom. Arantio impofuerit] See Ivlii Cae= saris Arantii . . . De Hvmano Foetv Liber Tertio editus, ac recognitus. Eivs= dem Anatomic arvm Observationvm Liber . . . Venetiis 1587. Anatomicae Obser= vationes. c. XXXIV p. 98. P. 172. 1. 6 from bottom. carnofas ferri fibras] See note to vol. I p. 135. 1. 9 from bottom. P. 173. 1. 16 from bottom. hinc] The original edition, Hafhiae 1664, has hie. Edd. Amstel. 1664 and Lugd. Batav. 1683 have hinc. P. 173. 1. 9 from bottom. per operationes cognofcendam] See Nicolai Massa . . . Liber Introduce torius Anatomise, Jiue dijfectionis cor= poris humani, nunc primum ab ipfo auc= tore in luce editus . . . Venetiis 1536. c. XXXII p. 67: . . &■ ideo rectius dicu tur caro mufculofa, non diftinguibilis, ficuti etiam funt labiorum mufculi, qui perfectionem minime dijiingui pojjunt . . . P. 175. 1. 11-12 from bottom. qvam fyringae veterum affimila* veris] See Francisci Glissonii . . . Anato- mia Hepatis . . . Londini 1654. c. XXI p. 211. P. 178. 1. 9-10 from top. in gallo Africano] The name of Gallina Africana is used by Gesner, Marcgraf 'and others for the guinea-fowl, Numida meleagris (L.). P. 179. 1. 5-6 from top. Plexus nervorum a Falloppio defcriptus] Falloppius was the first to describe the plexus of the pneumo« gastric nerve with its many branches to the heart. See Gabrielis Falloppii . . . Observations Anatomicae, In quinque libros digejtae . . . Opera & Jludio M. Iohannis Sigfridi Margfulenjis . . . Helm* stadii 1588. lib. IV c. XVpp.l84b-186. The original edition appeared in Ve» nice in 1561. P. 181. 1. 16 from top. Hippocrati . . . qvi dicit] See note to vol. I p. 169. 1. 15-16 from top. P. 182. 1. 8 from top. ego fumpfi] Edd. Amstel. 1664 and Lugd. Batav. 1683 have ego fum. P. 182. 1. 4 from bottom. Glandularum . . . natura] From here and onwards to the end the Trea» tise is chiefly taken up by a summary of Steno's discoveries as regards the anatomy and physiology of the glands. The greater part of it has consequently been mentioned before, in various places of the previous Treatises. In the notes to the following reference is made to the earlier Treatises, but only as far as the more important passages are con* cerned. P. 183. 1. 6 from top. mundas reddiderunt] Th. Bartholin published his discovery of the lympha* tic vessels in his book Vasa Lympha- tica, Nuper Hafniae in Animantibus inventa, Et Hepatis exfeqvix. Hafnia? 1653. See, moreover, note to vol. I p. 6. 1. 16 from bottom. Chap. VI p. 39 Bartholin writes: Sunt aquas in Oceano 258 NOTES falfae, funt & in fluvijs fontibusq; purse &faporis expertes odorisq; , fplendidio= res vitro, quibus Najades & Ephydvides, Nymphae puriffimae praefidebant. Nolu= mus has extra nos follicitare. Nymphas corporibus nqftris claudimus, & Najades invenis lymphaticis, fi fuperjiitiojis ejje liceret, veneraremur. — As regards the conglobate and conglomerate glands, see note to vol. I p. 20. 1. 17—18 from bottom. P. 183. 1. 7 from top. Wirtzungio debent conglomera* tae] Wirsung was the first to find the pancreatic duct in the human body (1642), Maur. Hoffman having dis* covered it the year before in a turkey. Shortly after his discovery U^i'rsung was killed by another physician. P. 183. 1. 9-10 from top. Whartoni. .. Deufingius] Whar- ton published his discovery of the duct of the submaxillary gland in his Ade= nographia . . . Londini 1656. The editor of the present Edition has not been able to find anything about Deusing's rela* tion to Wharton in those of Deusing's writings, which he has seen. P. 183. 1. 11 from top. Blafius] Concerning Steno's dis« covery of the parotid gland and Blaes' attempt to appropriate the honour of this discovery, see the Introduction and the previous Treatises passim, especially XIII. P. 183. 1. 14 from top. in Obfervationibus] Nicolai Ste- nonis Observationes Anatomicae . . . Lugd. Batav. 1662. It comprises II, IV, V and VI in the present Edition. P. 183. 1. 14-15 from top. reliqva . . . exponam] Steno never published any extensive work on the glands; but he returned to these organs in his descriptions of the dissections of some rays and sharks. See the Treatises XVI vol.1 p. 193, XXIII vol.11 p. 113 and XXIV vol. II p. 147. See, also, the Appendix, vol. II p. 308. P. 183. 1. 19 from bottom. Salivare exterius] See especially the Treatises I and II. P. 183. 1. 12 from bottom. Epicuri intermundia] Epicurus maintained that there was an infinite number of worlds, between which were large and empty spaces, and that the atoms, flying through these spaces, uni* ted and thus made one world upon the other. P. 183. 1. 10-11 from bottom. Apologise Prodromus] XIII vol. I p. 143 in the present Edition. P. 183. 1. 8 from bottom. de teftimoniis ejus] See the intro* duction to the notes to XIII, vol. I p. 252. P. 184. 1. 3-4 from top. Anagrammafticam Hobokianum] See note to XIII vol. I p. 146. 1. 3-4 from top. P. 184. 1. 9 from top. non erubuit] Concerning Steno's controversy with Deusing see especially the Introduction and Treatise IV in the present Edition. P. 184. 1. 14 from top. Buccarum vafcula] See II vol. I p. 26. NOTES 259 P. 184. 1. 12-13 from bottom. fublingvalia dicta] See II vol. I p. 27. P. 184. I. 5 from bottom. ad alia non attendi] Cf. XI vol. I p. 135. P. 185. 1. 6 from top. recipit vafa] See II vol. I p. 27. P. 185. 1. 16 from top. defcendens meatus] See VI vol. I p. 96 and the note to p. 96. 1. 18-19 from bottom. P. 185. 1. 14-15 from bottom. in . . . oefophago . . . vafa] See XI vol. I p. 135. P. 185. 1. 7 from bottom. Qva? narium tunicam irrigant vafcula] See VI vol. I p. 95. P. 185. 1. 2-3 from bottom. in ovibus.. .notatum] See VI vol. I p. 95. P. 186. 1. 2 from top. in narium cava devivantes] See III vol. I p. 56 ff. and V p. 83 ff. P. 186. 1. 13. from top. Vafa palpebrarum] See V vol. I p. 81 ff. P. 186. 1. 17 from bottom. in raja mihi confpecta] See XVI vol. I p. 196 ff. P. 186. 1. 10-11 from bottom. De Ufu Par Hum 1. 2.] Galeni De Usu Partium Corporis Humani Libri XVII. lib II c. 3. P. 187. i. 7 from top. qvibusfola evehentia contigere] Steno here, as always, describes the con* glomerate glands as belonging to the lymphatic system and looks upon the excretory ducts of these glands as lym* phatic vessels. P. 187. 1. 11 from bottom. ad abfurdas . . . opiniones] See notes to vol. I p. 32. 1. 8 from top and p. 68. 1. 6 from bottom. P. 187. 1. 8-9 from bottom. infertionis varietas . . . patebit] See XII vol. I p. 139 ff. and note. P. 187. 1. 2-3 from bottom. qvod . . . recipit] Ed. Hafniae 1664 has qva instead of qvod. P. 188. 1. 2-3 from top. per unicum . . . oftium] See note to vol. I p. 187. 1. 11 from bottom. P. 188. 1. 17 from top. ductui bilario . . . gemino] See IX vol. I p. 117. P. 188. 1. 8-9 from bottom. a . . . Highmoro . . . defcriptam video] See Corporis Hvmani Disqvisitio Anatomica; In Qva Sangvinis Circvla= tionem in quavis Corporis particula plu= rimis typis novis, ac AZnygmatum Me-- dicorum fuccincta dilucidatione omatam profequutus eft Nathanael Highmorvs . . . Hag3e*Comitis 1651. c. VIII p. 42 and plate IV p. 44. P. 188. 1. 3-4 from bottom. Whartoni fidens obfervationi] See Adenograpbia . . . Authore Thoma 260 NOTES Whartono. Londini 1656. c. XXI pp. 130-131. See, also, II vol. I p. 41. P. 189. 1. 3-4 from bottom. fubftantiam glandulofam] See VII vol. I pp. 101-102, XVI vol. I p. 196 and XXIII vol.11 p. 116 ff. P. 190. 1. 5-6 from top. In ventriculis cerebri] See XXVIII vol. II p. 234 ff. P. 190. 1. 9 from top. Humoris, unde &■ fit . . .foetus] See XXIV vol. II p. 153. Steno looked upon villi as being of glandular nature. P. 191. 1. 5 from top. mentis imperio fubjecta] As re* gards Steno's earlier view, which differs somewhat from the one expressed in this place, see the latter part of Treatise II in the present Edition, vol. I from § 30. p. 34, especially § 39. p. 38. P. 191. 1. 8 from bottom. Antonius Everhardi] See Novus Et Genuinus Hominis Brutique Anima= lis Exortus. Authore Anthonio Everardi. Mediobvrgi 1661. p. 280 ff. P. 191. 1. 1 from bottom. nullum videre potui tranfitum] See XI vol. I, especially p. 134 and note to p. 134. 1. 15 from top. P. 192. 1. 9-10 from top. nulla glandularum facta men< tione] See note to vol. I p. 28. 1. 4 from top. P. 192. 1. 11 from top. glandularum uti operculo] This possibly refers to a remark of Schnei= der's. See Conradi Victoris Schneideri Liber Qvintus Et Ultimus De Catarrho= sorum Diaeta. Wittebergae 1662. c. I pp. 84-85. XVI DE ANATOME RATA: EPISTOLA. The dissections of the two rays, on which this Treatise is based, must have taken place in Copenhagen shortly after Steno's return, in the spring of 1664. The Treatise is dated April 24 (old style) 1664, and was published the same year, the second of three Treatises in Nicolai Stenonis De Mtisculis S- Glandulis ob= fervationum fpecimen Cum Epijlolis du= abus Anatomicis. Hafhiae 1664. It is dedicated to Willem Piso (see note to vol. I p. 118. 1. 17 from top). P. 195. 1. 12-13 from top. primus viam monftrares] See IX vol. I p. 118. P. 195. 1. 14 from top. corvi aqvatici fectio] See IX vol. I p. 117 and note to p. 117. I. 7-8 from top. P. 196. 1. 1 from top. oblatam] All editions have ablatam. P. 196. 1. 10 from top. Binae nobis erant rajae] Probably Raja batis. See C. C. A. Gosch, Ud= sigt over Danmarks zoologiske Literatur. vol. II 1. Kjebenhavn 1872. p. 190. P. 196. 1. 1 from bottom. non tincta punctula] Steno's dis* covery of the mucous canals, and his other observations on the rays were carried on by his pupil Lorenzini in OsservazionilntornoAlleTorpediniFatte Da Stefano Lorenzini . . . InFirenze 1678. NOTES 261 P. 197. 1. 5-6 from top. id vidiffem faepiusj See VI vol. I p. 96. P. 197. 1. 15 from bottom. defectum fupplentes] SeeXIVvol. I p. 155, XV vol. I p. 172 ff., and espe* daily XXII vol. II p. 67. P. 198. 1. 14 from bottom. fuerint contextae] See XV vol. I p. 174. P. 198. 1. 9 from bottom. pafferem marinum praeter] As to what, at the time of Steno, was meant by asellus minor, solea and passer ma* rinus, see Historia? Naturalis De Pisci* bus Et Cetis Libri V. Cum arneis figu= ris Iohannes Ionstonvs . . . concinauit. Francofvrti Ad Moenum [1649]. pp. 7-8 plate I 2, pp. 87-90 plate XX and p. 99. P. 199. 1. 12 from top. xyftico]Ed.Hafniael664has/ ystico. P. 199. 1. 16 from bottom. nervea] See note to vol. I p. 95. 1. 11—12 from top. P. 199. 1. 3-5 from bottom. Simon Paulli . . . inferuit] See Si'= moms Paulli . . . Quadripartitum Bota= nicum De Simplicivm Medicamentorvm Facultatibus . . . Argentorati 1667. p. 84. In the first edition, Rostock 1639, this is not mentioned. P. 200. 1. 2 from top. eleganter] All editions have elegan= tes. P. 200. 1. 13 from top. ipfe pronuntiat] Exercitationes De Generatione Animalium . . . Autore Gvi= lielmo Harveo . . . Londini 1651. Exercit. 4. p. 1 1 : Infunt omnibus avibus, ferpen= tibus, quadrupedibus oviparis, atque eti= am pifcibus (ut facile in Cyprino videre ejl) renes, &. ureteres, per quos urina prqfluat .gvod Ariftotelem, aliofqve hac- tenus Philofophos latuit. — See also Aristoteles, De Animalibus Historia ('Ai Ttepi t& Zqia 'Iaropiai) lib. II c. 16. P. 200. 1. 12-13 from bottom. repletam] All editions have repletum. P. 201. 1. 9 from bottom. qvod . . . Simoni Paulli contigitj Simon Paulli may have communicated this to Steno by word of mouth; at any rate it is not mentioned in Paulli's writings. P. 202. 1. 2 from top. Rondeletium] See Gvlielmi Ronde= letii . . . Libri de Pifcibus Marinis, in quibiis verae Pifcium effigies exprejfae funt . . . Lvgdvni 1554. lib. XII c. 4. pp. 342—344. In this place we find the picture of a ray's egg, which is described simply as an egg, not as the uterus or thefish. Referencesto^lnsfofe/es, DeAnU malibus Historia ('Ai nepi xa Zata'laxopi- ai) lib. I c. 5, lib. II c. 13 and especially lib. VI c. 10. P. 202. 1. 2 from top. Gefnerum] See Conradi Gesneri... Hifloriae Animalium Liber HII. qui ejl de Pifcium 6- Aquatilium animantium natura . . . Tigvri 1558. p. 930, where Rondelet's description is reprinted ver- batim together with the picture of the egg- P. 202. 1. 2 from top. Jonftonum] I. c. p. 34 and plate XII 262 NOTES fig. 4, facing p. 37. — See note to vol. I p. 198. 1. 9 from bottom. P. 202. 1. 12 from top. uterum expofitum] See Harvey, Exercit.De Generat. Animal. Exercit. 22. p. 70: EJi Ovum (ut diximus) quaji ute* rus expofitus, et locus in qvo foetus formatur: matricis enim munus obit . . . P. 202. 1. 12 from bottom. Harvaeus Exerc. 68] Ibid. pp. 234— 235. P. 202. 1. 3 from bottom. exfpectant ovipara] As mentioned in the Introduction, Steno later on ar* rived at a far more correct view of this question, being the first to state that the testes of the females of the vivipa» rous animals were the same organs as those called the ovaria in oviparous ani« mals, and that also their function was exactly the same. See XXIV vol. II pp. 152-153. P. 203. 1. 5 from bottom. pictura Authorum] This refers to the figure mentioned in the notes to vol. I p. 202. 1. 2 from top. P. 203. 1. 3 from bottom, extracta] All editions have extracts?. P. 203. 1. 1 from bottom. propriae] This word is not found in the Edd. Amstel. 1664 and Lugd. Batav. 1683. P. 204. 1. 5 from bottom. afperae arteriae] Arteria aspera is the trachea. P. 205. 1. 9 from top. res . . . nulli controverfiae ob< noxia eft] Cf. Antiperipatias. Hoc Est Adversvs Aristoteleos De Respiratione Piscivm Diatriba . . . Marci Avrelii Se= verini . . . Neapoli 1659. p. 1, and Nova Experimenta Pneumatica Respirationem Spectantia. Authore Roberto Boyle. Genevae 1686. V. p. 12: Quaeritur etiam, Quoufque mereatur a nobis con= Jiderari, Nilmne in Aqua communi tan= turn Aeris lateat, qui ufui frigidorum ejufmodi Animalium, ut funt Pifces, fufficiat; atque num feparabilis ille Jit ab aqua, quae per branchias ipforum percolatur? P. 205. 1. 17-18 from top. non omnem. . . tranfmitti fangvi* nem] The foramen ovale in the auri* cular septum of the fetus as a rule is being completely obliterated at birth; but oc* casionally a small oblique passage is left between the two auricles. P. 205. 1. 8-9 from bottom. ut in ranis] See Malpighius' De Pul= monibus Epistolee II ad Borellium. Bo* noniae 1661. — Malpighius was the first to discover, by means of the microscope, that the ramifications of the trachea termi* nate in small vesiculae (alveoli) sur» rounded by a fine network af arteries and veins. But it was not until he had begun to investigate lower animals, like frogs, that he succeeded in proving the ana» stomosis of the arteries with the veins through the capillaries. As to Steno's earlier view of this discovery see XI p. 131. 1. 9 from top and note. P. 206. 1. 3 from top. Apelles] See note to vol. I p. 14. 1. 19 from top. P. 206. 1. 8-9 from bottom. ex . . . tuis de itinere Brafilienfi NOTES 263 fermonibus] The work Historia Na= tvralis Brasiliae . . . Lvgdvn. Batavorvm et Amstelodami 1 648 contains Guilielmi Pisonis . . . De Medicina Brasiliensi Li* bri Qvatvor and GeorgI Margravl . . . Historic Rervm Natvvalivm Brasiliae, Libri Octo. — See note to vol. I p. 118. 1. 17 from top. P. 207. 1. 9 from top. Bartholinus] Th. Bartholin while a professor at the University of Copen* hagen often left town for long periods at a time and went to live at his estate Hagestedgaard. XVII DE VITELLI IN INTESTINA PULLI TRANSITU EPISTOLA. The observation, on which this Trea* tise is based, must have been made after Steno's return to Copenhagen in the spring of 1664, and before the 12th of June (old style), the date of the Treatise. It was published together with the two previous Treatises (XV and XVI) in Nicolai Stenonis De Musculis &■ Glan= dulis obfervationum fpecimen . . . Haf* niae 1664. It is dedicated to PaulusBar* bette, a celebrated Amsterdam surgeon and author of medical books. See JBiogr. U^oorc/enboeA: der Nederlanden. vol. II 1. p. 107. In this Treatise Steno mentions his discovery of the vitelline duct in the newly hatched chicken. Observe, how* ever, that this formation in the fetus of the hen was known and described as early as by Aristotle l), who also knew that the function of the vitelline duct was that of conducting the yolk into ') De Animalibus Historia. VI 3. De Generatione Animalium. Ill 2. the intestines of the fetus, with the view of nourishing the latter. But Aristotle entirely misunderstood the manner in which the vitelline duct originates; he thought that is was a transformation of one of the two Jiopoi cp\e|3ixoi that pro* ceed from the heart at an early stage of the fetal life. The knowledge of the vitel* line duct was preserved throughout the antiquity, until as late as the 16th century, its formation and function being very clearly described in 1573 by Volcherus Coiterus1). But after that, strange to say, the knowledge of the vitelline duct was lost, and though of course prominent investigators like Fabricius ab Aqvapen= dente,-) Spigelius*) and Harvey*) tho» roughly knew the works of their pre* decessors, from Aristotle to Coiter, they did not understand that Aristotle and all his successors described a pas* sage from the yolk*sac to the intestines, through which passage the yolk was conducted to the intestines with the view of nourishing the fetus. In their own investigations they never themselves came across the vitelline duct, and ac* cording to Harvey the nourishment of the fetus took place in a twofold man* ner, partly by the fetus swallowing the amniotic fluid, partly by its receiving the purior et sincerior pars of the latter direct into the vascular system through the umbilical veins. ') Extemawm Et Internarvm Principalivm Hv- mani Corporis Partivm Tabvbe . . . Avtore Vol' chew Coiter . . . Noribergae 1573. pp. 35-36. 2) Hieronymi Fabricii Ab Aqvapendente De Formato Foetv. Venetiis 1600. Hieronymi Fabricii Ab Aqvapendente . . . De Formatione Ovi. Et Pvlli Tractatvs Accvratis. simvs . . . Patavii 1621. ") Adriani Spigelii . . . De Formato Fotv Liber Singvlaris . . . Patauij 1626. *) Exercitationes De Generatione Animalium . . . Autore Gvilielmo Harveo. Londini 1651. 264 NOTES Thus, when Steno found the vitelline duct and correctly described its function, it was to him and his contemporaries a new and highly important discovery, though it may seem strange that this discovery had to be made afresh. In a letter to Thevenot, written after 1665 and printed two years later as part of Elementorum Myologix Specimen, Flo* rentiae 1667, p. 49 (XXII vol. II pp. 95—96 in the present Edition), Steno tells that it had been brought against him as a charge that the same discovery had been made at an earlier period by Coiter, Huibertus and Meibomius. As is mentioned above, it is quite true that Coiter had described the vitelline duct, but Steno was right in maintaining that when Harvey, who had spent several years of his life in studying these mat* ters, did not understand Coiter's descrip* tion, it was perfectly pardonable that he himself, who had never until then had anything to do with this subject, did not understand it either, while on the other hand he cannot be said to be right, when he maintains that Coiter expressed himself indistinctly. As regards Huibertus the editor of the present Edition can give no infor* mation, not even as to his identity, and as to Meibomius' connection with this discovery of Steno's he has likewise been unable to find anything. However Steno was not the first to find the vitelline duct, after the know* ledge of it had been lost. Three years after the appearance of his above*men* tioned book Needham relates that he had found the vitelline duct as early as 1654, however without having pub* lished his discovery.1) As to the demonstration of the vitel* line duct in placental animals see the introduction to the notes to Treatise XXVI vol. II p. 167. See, moreover, Vilhelm Maar, Om Opdagelsen af duc= tus vitello=intestinalis. Det Kgl. Danske Videnskabernes Selskabs Forhandlinger. 1908. V p. 233 ff. The figure belonging to this Treatise is to be found on p. 163 of this volume (right corner at the bottom). P. 212. 1. 19 from bottom. vac a bit] Ed. Hafniae 1664 has vo= cabit. P. 213. 1. 18-19 from bottom. juxta obfervationes Harvxi] See Exercit. De Generat. Animal. Exercit. 52 p. 164: Ariftoteles quidem decimo poft nativitatem die, aliquid vitelli fuper= ejje reperit: nos autem, etiam poft fex feptimanas, nonnihil ejus, in ventre pulli, intejiino affixum vidimus. P. 215. 1. 17 from bottom. authoritas Ariftotelis HarvxU qve] See Aristoteles, DeAnimalibus Hu storia ('Ai nepl xd Zqkx 'Ioropi'ai) lib. VI c. 3 and Exercit. De Generat. Animal. Exercit. 52 p. 164: qua? [sc. venae] om= nes in unum truncum collects, in venam Ports perforantur ; pleniorifque injecore coctionis gratia, partem vitelli, quam ab= forbent, eb deferunt. ') Disquisitio Anatomica De Formato Foetu. Authore Gualtero Needham. M. D. Londini 1667. c. IV p. 97 ff. QL Steno, Nicolaus 805 Opera philosophies S7 1910 v.l Biological Be M- PLEASE DO NOT REMOVE CARDS OR SLIPS FROM THIS POCKET UNIVERSITY OF TORONTO LIBRARY