514 MEDICAL JURISPRTTDENCE hours after swallowing the poison he passed per rectum two lumps, one weighing eighty grains and the other weighing twenty-five grains.25 Arsenious oxide is converted into yellow sulphide of arsenic in the stomach and intestines, but sulphide of arsenic is not converted into white arsenic. 5. Elimination. — Arsenic, when taken for some time in medicinal doses, does not accumulate in the system, so that it may give rise to sudden poisonous symptoms. It is, therefore, not regarded as a c , Arsenic is eliminated through the urine, faeces, skin, hair and nails, and | to some extent through the sweat, saliva, bile, bronchial secretion and milk. After its administration arsenic appears in the urine and fseces usually from two to eight hours, but it may be detected within half an hour after a single dose of five drops of liquor arsenicalis (Fowler's solution) . The elimination by these channels continues for a period of two to three weeks, after which arsenic is not found in the urine and faeces, although it may be found in the hair and nails. A case is, however, recorded in which arsenic was detected in the urine ninety-three days after the administration of a single large dose, which produced the symptoms of acute poisoning followed by paralysis.20 In his annual report for the year 1935, the Chemical Analyser of Bombay describes a case in which a man sustained severe injuries including a pene- trating wound of the abdomen and laceration of the left hand from the explosion of a powder consisting of potassium chlorate and arsenic sulphide contained in a porcelain jar. Six days after the explosion the man's urine was found on analysis to contain 1/250 grain of arsenic. Twenty days after this the man developed dermatitis, and his hair and nail parings were found to contain 1/25 grain of arsenic. In this explosion arsenic seems to have entered the system through the wound and also by inhalation of arseniu- retted hydrogen which is evolved in the explosion. Willcox ^7 reports a case in which a Government official of a tropical country was administered arsenic on October 6, 1922, and the chemical analysis of his hair revealed the presence of arsenic on December 19, 1922, when he was suffering from the symptoms of chronic poisoning. Arsenic was also detected in the proximal portions of the hair 'in a case where a woman, 74 years old, died 30 hours after the toxic symptoms had commenced and where the body was not exhumed until 9 years and 4J months.28 By dividing hair in small successive lengths from the root upwards and analysing them separately one m'ay obtain important information regarding the time that has elapsed since the administration of arsenic. For instance, if arsenic is administered to a patient daily for a few days and then dis- continued, the portion of the hair growing during this period yields a much larger amount of arsenic than the portion growing during the non-arsenic period. The time depends upon the rate of the growth of hair which is generally about half an inch per month. Bagchi describes a case in which he was able to show on analysing the distal and proximal ends of the hair that a patient suffering from suspected arsenic paralysis had been given arsenic two to three months before his admission into hospital in Patna.20 In the fatal cases of acute arsenical poisoning where the patient has survived for ten to fourteen days, it is hardly possible to find the poison in the viscera usually preserved for chemical analysis, although arsenic was detected in the viscera of a woman who survived fifty-two days after taking 25. Ind. Med. Gaz., 1872, p. 183. 26. Wood, Boston Med. and Swrg. Jour., .1893, C. XXVIH, p 414. 27. Lancet, Jan. 27, 1923, p. 168. P" 28. E. G. Young and R. P. Smith, Brit. Med. Jour., Feb. 21, 1942, p 251 29. Patna Jour, of Med., Jan. 1936, p. 7.