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Full text of "Medical Jurisprudence And Toxicology"

THALLIUM:

545

5.    Lead is eliminated largely in the faeces, and to a small extent in the
urine.   It is also slowly excreted in the bile, saliva, milk, and hair.   How-
ever, being a cumulative poison, lead tends to accumulate in the system,
Chuni Lai Bose15 reports that lead was detected in the urine of a man
about six weeks after he was poisoned by white, lead taken in mistake for
betel-lime.

6.    Idiosyncrasy plays a great part in the effects of the poison.   Some
people, even though exposed to the action of lead salts, may not be affected.
Persons addicted to alcohol are more prone to the attack of chronic poison-
ing.   Gouty persons are soon affected; it should, however, be remembered
that chronic poisoning develops gout and granular kidneys.

7.    Not only does abortion occur is a pregnant woman suffering from
chronic lead poisoning usually between the 3rd and 6th months, but a healthy
woman, if impregnated by a man suffering from chronic lead poisoning, is
likely to abort.

Children are more susceptible to lead poisoning than adults, the central
nervous system is particularly susceptible in them. Children suffering from
chronic lead poisoning are generally backward in their studies even after
recovery, as their mental development is often affected.

Infants may suffer from slow and progressive lead poisoning by imbibing
lead secreted in the milk of their mothers who are poisoned by face powders,
skin cosmetics and hair dyes containing lead. The other sources of poison-
ing in infants are feeding bottles made of glass containing lead and lead
nipple-shields.

8.    Blair Bell, Williams and Cunningham16 have carried out investiga-
tions   on  the  toxic   effects  in  the  human  subject   of  lead   administered
intravenously.   The lead used was metallic lead in colloidal form for the
treatment of malignant neoplasms.   They have shown that there is great
difference in individual tolerance to lead, and that the male is more tolerant
than the female to the toxic effects of lead, as the following figures tend to
demonstrate:

Maximum and Minimum amount of Lead required to produce
Toxic Symptoms: Average for all ages

Maximum
		Minimum
	
Males
	Females
	Males
	Females

0.34 g.
	0.29 g.
	0.1 g.
	0.04 g.

THALLIUM

Thallium is a soft, heavy metal, having a tin-white, lustrous colour, but,
on exposure to the air, tarnishes upon its surface, owing to the formation of
black thallous oxide. It is chiefly used in the dye and glass industries.

The chief salts of thallium which are of value from a toxicological point
of view are thallium acetate and thallium sulphate.

Thallium acetate was used as a remedy for the night-sweats of phthisis,
but is now used only as a depilatory in the treatment of ringworm .of the
scalp. It is administered to children under ten years of age in the dose of
8 to 8,5 mg. per kilogramme of body weight. The hair of the head begins

15.
16.

35

Calcutta Med. Jour., Feb. 1916.
Lancet, Oct. 17, 1925, p. 793.