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68                  PA THOGENIC BA CTERIA.

with a temperature equally high, readily falls a victim
to anthrax without a cold bath.

(b)  By altering the chemistry of the blood by changing
the diet or by hypodermic injection.    Leo  found that
when white rats were injected with or fed upon phlorid-
zin an artificial o-lvcosuria resulted which destroyed their

o   -

natural resistance to anthrax. Hankin found that rats,
which possess considerable immunity to anthrax, could
be made susceptible by a diet of bread. Platania suc-
ceeded in producing anthrax in dogs, frogs, and pigeons,
naturally immune, by subjecting them to the influence
of curare, chloral, and alcohol.

(c)  By diminishing the strength of the animal.    Roger
by compelling white rats to turn a revolving wheel until
exhausted destroyed their immunity to anthrax.

(d)  By removing the spleen (?).     A large number of
experiments have been  performed   by  various   investi-
gators to show that the removal of the spleen does or
does not affect immunity.    From  their work  it seems,
proper to conclude that the spleen has little, if any, in-
fluence upon the vital resistance to disease.

I.  Bardach,1 Righi,2and Montuori3 seem to have shown
that the removal of the spleen lessens the ability of the
organism to combat the infections.

II.   Blunienreich and Jacoby,4 on  the contrary, found
that the removal of the spleen was followed by a hyper-
leucocytosis, an increase in the bactericidal power of the
blood, and consequent increase of immunity.

III.  Milkinow-Raswedenow5 found that the removal of
the spleen was a weakening factor in the immunization
of animals.    The spleen itself,  however,  was of little
importance in combating the micro-organismal infections.

Kurlow6 concluded from his experiments that the in-

1 Ann. de r Inst. Pasteur, 1889, No. 2, p. 577, and 1891, No. I, p. 40.

* La R if or ma Medic-a, 1893, PP- 170, 171.

3 Ibid., Feb., 1893, 17, 18.   - * Berlin, klin. Wochemchrift, May 24, 1897.

5 Zeitschrift fur Hygiene, 1896, xxi., 3.

 Archivfur Hyg., 1889, Bd. ix., p. 450.