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SUPPURA T10N.                          303

periments, finds that the gonococcus grows best in a mix-
ture of I part of pleuritic fluid and 2 parts of 2 per cent,
agar. Wright1 prefers a mixture of urine, blood-serum,
peptone, and agar-agar.

It is ordinarily presumed that gonorrhea cannot be
communicated to animals, but Turro asserts that the
gonocoeci when grown upon acid gelatin readily com-
municate nretlirilis to dogs, and that no Icesio contimd is
necessary, the simple introduction of the organisms into
the meatus sufficing to produce the disease.

The injection of gouococci into the subcutaneous tissue
does not produce abscess.

There is no doubt that the gonococcus causes gonor-
rhea, as it has on several occasions been intentionally
inoculated into the human urethra with resulting typical
gonorrhea. It is constantly present in the disease, and
very frequently also in the sequelae—eiiclonietritis, salpin-
gitis, oophoritis, cystitis, peritonitis, arthritis, conjuncti-
vitis, endocarditis, etc.—and, so far as can at present be
determined, is never found under normal conditions.

In the beginning of their activities the cocci grow in
the superficial epithelial cells, but soon penetrate between
the cells to the deeper layers, where they continue their
irritation as the superficial cells desquamate. Authorities
differ as to whether the gonococci can penetrate squamous
and columnar epithelium with equal facility.

The periurethral abscesses that occur in the course of
gonorrhea are generally due to the Staphylococci aureus
and albus, not directly to the gonococcus.

In certain of the remote secondary inflammations the
gonococci disappear after a time, and either the inflam-
mation subsides or is maintained by other bacteria. In
synovitis this does not seem to be true, and the inflam-
mation excited may last for months.

As long as the gonococci persist the patient may spread
contagion. It must be pointed out that after apparent
recovery from the disease the cocci sometimes remain

iy«w. *>f ///<? Amer. AfeJ. Assoc., Feb., 1895.