LEPROSY. 247 son,1 the bacteriological diagnosis of nodular leprosy can be made by spreading the serum obtained by scraping a leprous nodule upon a cover-glass, drying, fixing, and staining with carbol-fuchsin and Gabbet's solution as for the tubercle bacillus. In such preparations the bacilli are present in enormous numbers, thus forming a marked contrast to the tubercular skin diseases, in which very few can be found. In that form known as anesthetic leprosy, nodules form upon the peripheral nerves, and by connective-tissue formation, as well as the entrance of the bacilli into the nerve-sheaths, cause irritation, then degeneration, of the nerves. The anesthesia which follows these peripheral nervous lesions is one of the conditions predisposing to the formation of ulcers, etc. by allowing injuries to occur without detection and to progress without observation. The ulcerations and occasional loss of phalanges that follow these lesions occur, probably, in the same manner as in syringomyelia. The disease advances, having first manifested itself upon the face, extensor surfaces, elbows, and knees, to the lymphatics and the internal viscera. Death ultimately occurs from exhaustion, if not from the frequent inter- current affections to which the conditions predispose. 1 Montreal Med. Journal, Jan., 1897.