SYPHILIS. 359 gives place to the formation of septate, V-shaped, and "branched forms. It seems to be normally a strepto-ba- cillus in its early stages, but eventually becomes very pleomorphous, varying in appearance from a chain of oval cocci to the hypha of the moulds. There seems to be nothing peculiar about the staining-capacity of the bacillus. It stains with the ordinary solutions of the anilin dyes, retains the stain of Gram's method, and is decolorized by mineral acids. Dohle* succeeded in staining certain protoplasmic bodies in the tissues in syphilis, which resembled the actively motile protoplasmic bodies which he had pre- viously encountered in the discharges. They were for the most part round or oval, sometimes with irregular outlines, and were provided with flagella. The staining took place in a mixture of hematoxylon and carbol-fuch- sin, subsequently treated with iodin or chromatin, and washed in alcohol. Convinced that these bodies were the cause of syphilis, he excised small fragments from gummata and other syphilitic tissues, and placed them beneath the skin of guinea-pigs, which subsequently fell ill with a chronic marasums which ultimately caused death. In the inoculation experiments of van Niessen there were observed as evidences of the specificity of the organism discovered by him: (i) abortion in pregnant female rabbits; (2) extra-genital primary lesions on the ears of inoculated rabbits in the form of nodes; (3) sec- ondary ulcer and tumor formations, and irregular lesions, such as occasional thrombosis and pneumonia. 1 Munch, med. Wochenschrift, 1897, No. 43.