TETANUS. 283 until there is sufficient toxemia to produce spasms, and that therefore it is impossible to attack the disease in its inception; we are obliged to meet it upon the same grounds as diphtheria in the later days of the disease— a time when it is well known that the chances of im- provement are greatly lessened. Of course, as there is no other remedy that combats the disease at all, the antitoxin is one which, when ob- tainable, should always be employed. An interesting observation has been recently made by Wasserman,1 who, assuming that the destruction of nerve-cells in the cerebrum and cord during tetanus tox- emia might have something to do with immunity, be- lieved it possible to obtain from these cells an immuniz- ing substance. Investigating the subject, he found that when fresh brain or spinal cord was rubbed up in a mor- tar with physiological salt solution, and injected into ani- mals, the mixture had the power not only to confer upon. them an immunity lasting for twenty-four hours, but also was potent enough to neutralize the effects of an injec- tion of tetanus toxin ten times as large as that necessary to kill the animal in doses of i c.cm. These observations may offer a possible solution of the difficult problem laid before us by Montesano and Mon- tesson,2 who unexpectedly found the tetanus bacillus in pure culture in the cerebro-spinal fluid of a case of para- lytic dementia that died without a tetanic symptom. 1 Berlin, klin. Wochenschrift, 1898, No. I. 2 Centralbl.f. Bakt^ u. Parasitenk., Bd. xxii., Nos. 22, 23, p. 663. Dec., 1897.