TYPHUS MURIUM. 4*5 portance. Agar-agar cultures are best, as being most readily transportable. They are broken up in water and well stirred, and the liquid poured upon a large num- ber of small pieces of broken bread. These are next to be distributed with reasonable care. Instead of being carelessly scattered over the ground, they should be dropped into the fresh mouse-holes, and pushed suffici- ently far in to escape the effects of sunlight upon the bacilli. Attention should be paid to holes in walls, under railway tracks, etc. and other places where mice live in greater freedom from disturbance than in the fields. (3) The attempted eradication of the mice should be begun at a time of year when the natural food is not plenty. By observing these precautions the mice can be eradicated with certainty, usually in a period of time not exceeding eight to twelve days. For this purpose, in the course of two years, no less than 250,000 cultures were distributed from the Bacteriological Laboratory of the Tierarznei. Institut in Vienna. The bacilli are not pathogenic for the animals, such as the fox, weasel, ferret, etc. that feed upon the mice, do not affect man in any way, and so seem to occupy a useful place in agriculture by destroying the little but almost invincible enemies of the grain.