45° PA THOGENIC BA CTERIA. A. Catanni, Jr.1 trephined rabbits and injected influ- enza toxin into their brains, at the same time trephining control-animals, into some of whose brains he injected water. The results were that animals thus receiving 0.5-1 ingr. of the living culture constantly died in twenty-four hours with all the nervous symptoms of the disease, dyspnea, paralysis beginning in the posterior extremities and extending over the whole body, clonic convulsions, stiffness of the neck, etc. Control-animals injected with a variety of pathogenic bacteria in the same manner never manifested similar symptoms. The virulence of the bacillus was also observed to increase rapidly when transplanted from brain to brain. 1 Zeitschrift fur Hygiene, etc., Bd. xxiii., 1896.