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45                 PA THOGENIC BA CTERIA.

A. Catanni, Jr.1 trephined rabbits and injected influ-
enza toxin into their brains, at the same time trephining
control-animals, into some of whose brains he injected
water. The results were that animals thus receiving
0.5-1 ingr. of the living culture constantly died in
twenty-four hours with all the nervous symptoms of the
disease, dyspnea, paralysis beginning in the posterior
extremities and extending over the whole body, clonic
convulsions, stiffness of the neck, etc. Control-animals
injected with a variety of pathogenic bacteria in the
same manner never manifested similar symptoms. The
virulence of the bacillus was also observed to increase
rapidly when transplanted from brain to brain.

1 Zeitschrift fur Hygiene, etc., Bd. xxiii., 1896.