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American Journal of Dermatology
and Genito-urinary Diseases
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VOL. VII. w|
JANUARY, 1903.
No. 1.
vustogen
bi the Treatm^it of Gonorrheat
both acute and chronic, the advantage of thorough disinfection of the
entire urinary tract is apparent.
Cystogen is eliminated through the urine and gives to that fluid
antiseptic properties. It makes the urine sweet and bland.
This bland and antiseptic urine bathing in its downward course the
tubules of the kidneys, the ureters, the bladder and the urethra, prevents
the extension of the disease and assists in its abatement.
The practice of continuing the use of Cystogen for some weeks after
all symptoms have disappeared, establishes the cure as no other treat-
ment will. Dose: 5 grains, dissolved in water 3 to 4 times daily.
Procurable of all wholesale druggists.
Powdered, per ounce $1.00, per 8 ounce package (Ho^ipital 5ize), $4.00.
5 ffcaln tablets, per ounce, $1.10. per 8 ounce package (Hospital Size), $5.00.
5 grain tablets In paper boxes of as tablets each, per dozen boxes $4.00.
Cystogen Aperient, (Granular Effervescent Salt of Cystogen with Sodium
Phosphate), per dozen bottles $8.00.
Samples
on request.
C-JJ.
Cif^toaen
Chemical Co.[
'^T. LOU/S, Mo. i/jSA.
Write for
Literature.
Kntcrcd at the Foit-Officc at St, Louis. Mo., as second-class mail matter.
eSPINAL DEFLECTIONS ARE CONQUERED@
perfected system and appliances of
The banning
O. & M.-T. CO.
ONLY AWARD AT CHICAGO, 1893.
ONLY AWARD AT PARIS, 1900.
FORTY-EIGHT HEDALH AND DIPLOMAS.
Pig. S8. Botary Ourvature
Flf. SI. Antero-Poaterlor
Ourvature, Inor«aiiiic.
Fiff. Sa. Ant«ro- Posterior
Ourvatur*. Decreasing.
Fig. 94. Botary Curvature
Deoreaslng.
F iff 8. 23 and 94. In Bilateral or Rotary Curvature, to reverse the force of the body's weight to the
opposite side at each point of curvature, i» tne true philosophy of cure.— Uanming.
Figs. 31, 22 and 27. In Simple Drooping, iJpinal Irritation and Antero-
posterior Curvature, to lift the weight of head and shoulders from the
tender spinal points, and by pushing forward the dorso-lumbar curve transfer
pressure to central portions of bodies of vertebrse, is the aheet- anchor of hope.
— Uannino.
Nothing in nature has the inherent physical power to correct iu own im-
proper relation to gravity. ''As the twig 18 bent the tree is inclined'* is as true
of the child as of the twig. Why, then, the absurd prognosis of "The child will
outgrow it?"- Banning.
Spinal curvatures are created and perpetuated by a deflected spinal center
not by an unequal muscular antngonisni. The latter is purely adaptive. Hence
the failure of^ exercise, massage, electricity and muscle-cutting to remedy.—
• Hanmno.
And whatever we may do in these spinal cases, nothing must compromise o
put in jeopardy the very largest liberty and power of the Spinal, Abdominal and
Pectoral Muscles.— Banning.
SPINAL IRRITATION.
(From Dr. E. P. Banning's essay, "The Uuman Spine." Mailed Free.)
* * * However obscure and unsatisfactory the various pa-
thologies of irritation of the spinal tissues are, and however un-
successful the counter-irritating treatments may be, one thing is
nearly infallibly certain, if you place your hands under each
axilla and gently lift for h\e minutes— or if you at the same time
support the abdomen and the small of the back— the greatest
sufferers universally speak of a sense of rest from uneasiuess
and pain. Now whilst this cannot prove the existence of any
particular condition of the spine, it must clearly show that weight
and friction on the vertebrae aggravate the local and radiated
sufferings, and most forcibly suggests that a par^ of the remedy,
at least, is to elevate the abdominal viscera from the irritable
uterus and ovaries, and at the same time a part of the weight
from the irritable cartilages, ligaments and nerves, and also to
preserve the privileges of air, exercise and the diversions of society.
Fig. S7. Spinal Prop for Spinal
Irritation without Curvature.
SappertinsT the abdomen, ex-
pandiDe the waist and che8t,and
supporting the weak spine; also
reflevine spinal irritation, by
taking the weight of the body
from tender spinal points, and
protecting tbe latter in the case
of jolting and twisting the body
Send for Deseriptlve Price List. Measuring Blank and Dr. Bannlng's Bssay, "The Human Spine." Address.
BANNING 0.&M.-T.C0.,81 Berry St., Ft. Wayne,lnd.
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.^■v
A BI*MONTHLY MAQAZINC DCVOTCD TO ▼HC «ON9IOCIIAT|ON OF CUTANEOUS MCDICINC
VCN4IICAL DISCASCB ANQ aCNITO-URINAIIY SUWaSIIY.
S. C. MARTIN. M. 0.
P W Or «— on or OffRMATOLOOV IN THC BAHNU MCOIOAL OOLUat
EDITORS
G. M. PHILLIPS. M. 0.
PNorusoii or acMrro>uiimAfiv diokams tr. LO«fis o mj ua m or
PNVIICIANO AND •UNQCONO.
MANAGING BDITOR
S. C. MARTIN. Jr.. M. 0.
SUBSCRIPTIONS AND ADVERTISING.
The subscription price of this Journal Is $x.oo per year, in advance, postage prepaid* for the United States, Canada and
' Mexico; $i jo per year for all foreign couairles Included in the postal union. Slnpc copies, as cents.
Advertising rates will be furnished upon application.
Address all communications, correspondence, books, matter refardlag advertising, and make all checks, drafts and post-
office orders payable to
AMERICAN JOURNAL OF DERMATOLOGY
PjdeHty Building St. Louis. Mo . U S. A
Vol,, vn.
JANUARY, 1908
No. 1.
iN THE PRESENT STATUS OF BACTERh
OLOQY CAN ITS RELATION TO CUTA^
NBOUS PATHOLOGY BE ACCU-
RATELY DEFINED?
The relation of micro-organisms to
both contagious and non-contagious
diseases of the skin is so indefinite and
confusing to the mind of the practical
physician, that, in order to promote
uniformity in methods of practice, the
American Journal of Dermatology has
instituted an inquiry among prominent
specialists and scientists, to determine
as far as possible the limitations of
this new factor in the etiology and pa-
thology of cutaneous disease.
Many thoroughly educated and ex-
perienced clinicians claim that in most
diseases of the skin micro-organisms
are incidental or secondary factors,
while others affirm, with Unna, that
they stand in close causal relation to
nearly all skin diseases. The follow-
ing statements will shed considerable
light on this interesting and trouble-
some subject:
J. Abbott Camtbxll, M. D., late Professor of Diseases
of the Skin, Philadelphia Polydinie, Pittabnii^,
Pennsylvania.
Answering your question in a per-
sonal manner, I desire to say that I
am not so confidently imbued with the
thoroughness with which my co-work-
ers in the field of dermatology have
ascribed the bacterial origin of disease.
I believe that after all good, conscien-
tious workers have labored with the
microscope in this branch, that they
will soon equalize matters and find that
many of the so-called bacteria have no
effect upon the production of certain
conditions. This time may be far dis-
tant or nearer than we can now fore-
see.
Thubston O. Lusk, M. D., Instructor of Dermatology in
tne New York Post-Oraduate Medical School and
Hospital, New York City.
To answer your question, defining
the limitations of bacteria in dermatol-
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Original Articles.
ogy, will require years of study and
research. We are only beginning to
make headway in that direction , and
the progress is necessarily slow. Any
of the recent text-books on the subject,
however, will give all we know at the
present time, and it will be found suf-
ficient for practical purpose?.
If you should publish all the answers
received to your question there would
undoubtedly be among them quite a
number of conflicting opinions, and in
this age of science it is not opinions
but facts that we want and expect.
Henry Gc. -Phtabd, M. D., Professor of Dermatologyt
QalTersitT and Bellevue Hospital Medical College*
WSw York aty.
The subject of bacteriology in con-
nection with dermatology is too large
a one to tackle at present. When the
bacteriologists ai*e all through I may
have something to say from a prac-
tical standpoint. Until then you must
excuse me.
William Allen Pusky, M. D., Professor of Dermatology
and Clinieal Dermatology, College of Physicians and
Surgeons of Chicago, Chicago, Illinois.
An expression of opinion as to the
extent of the role that bacteria play
in dermatology would require consid-
erable labor and time, and I am at
present so crowded with work that I am
not able to undertake it.
ISADOBB Dyer. M. D., Professor of Dermatology in the
New Orleans Polyclinic, New Orleans, Louisiana.
At the present time it seems rather
hard for me to be able to cover the
ground in the matter of bacterial etiol-
ogy in skin diseases, especially with
Unna leading the school of those argu-
ing the parasitic origin of eczema and
its cogeners.
I am so much a clinician in my work
and teaching that I have inclined rather
to an indifference to the point of shai'p
definition in this class of skin diseases.
I believe that we are far from classify-
ing skin affections, and that the field
is too young to make positive distinc-
tion of etiology based on micro-organ-
isms as the causal factor. This does
not mean that there are not some dis-
eases of distinct bacterial origin, but
the borderland is so elastic that to-day
\% depends muojli on the view-point of
the individuid observer as to whether
certain diseases are primarily or sec-
ondarily microbic. It would require
much time to be exhaustive on this
subject, and just now I am only able to
give you this cursory opinion.
Herman G. Klotz, New York City.
There can be little doubt that bac-
teria play an important part in the eti-
ology of cutaneous diseases. How-
ever, our exact knowledge of the
micro-organisms and of their biology
is by no means commensurate with the
enormous amount of what is said and
written about bacteria, their toxines or
products, etc. With dermatology itself
to a certain extent in a more or less
chaotic state of revolution, and bacte-
riology still in one of evolution, it
seems that the time has not yet ap-
peared for setting up definite limita-
tions of the new factor.
Granville MacGowan, M. D., Professor of Diseases of
the Skin, College of Medicine, University of Southern
California, Lios Angeles, California.
I am not one of those who believe
that the ultimate cause of all diseases
of the skin may be traced to the growth
of molds or to the poisonous materials
resulting from such growths.
This theory is certainly an attractive
one, and has caused much valuable re-
search by a few who possess a prac-
tical working knowledge of dermatol-
ogy, with the skill and experience nec-
essary for culture work and the apti-
tude to draw approximately correct
conclusions therefrom. At the same
time it has given rise to a mountain of
nearly worthlese bacteriological literary
lore, put forth by a multitude of in-
competent workers, to further confuse
the literature of dermatology, which
already needs much simplifying to be
understood by the ordinary man of
medicine.
Yet, out of all this useful and use-
less research some good comes some-
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Present Status of Bacteriology.
times — a million eggs so that one fish
may grow to maturity.
Diagnosis of diseases of the skin is
certainly not greatly helped, as a yule,
by the assistance rendered by the lab-
oratory. As a guide to practice we
need to have before us continually the
imprints upon the skin, the clinical im-
pressions or pictures of disease which
the etiology, bacterial or otherwise,
stamps there.
Once familiar with the pictui'e, in
crossing a bit of gfass land or chap-
paral, it is very easy to tell where
sheep have passed, by the close crop-
ping of the grass and the trampling of
the soil by the myriads of hoofs. A
sheepman will tell you the kind of
iifliaq|j in the band, how long it is since
they wiirt hf^ 11m character of the
shepherd, and hemay gonlo a Innwd
dissertation upon the sheep.
Sabourand will do the same thing in
relation to tinea. This but few of us
will ever learn, but it is well that some
should know it and explain it, for the
knowledge may some time prove useful.
For the many it is sufficient that hav-
ing found a sheep or tricophyton it
may be killed for the good of human-
ity. But we should have protection
from the individual who, not being fa-
miliar with the general characteristics
of sheep, finding one should kill him
and claim a reward for his body, on the
suspicion that he had robbed a bee-hive,
because his meat was sweet.
Let the bacillus introduced into der-
matology as an etiologist bring with
him from his sponsor such a descrip-
tion of birth, childhood, youth, ma-
turity and progeny that anyone sup-
plied with proper apparatus for cult-
ure work and of reasonable experience
may isolate it from a given case of dis-
ease. Without these qualifications no
recognition should be extended by
those who write books or orally in-
struct others, to the claims of observ-
ers who would seek to trace the origin
of any of the diseased conditions of
the skin that are not already fully dem-
onstrated in a new bacillus or coccus.
Hbnry W. Stelwaqon, M. D., CHnical Professor of Der-
matology in the Jeflfenon Medical College, Philadel-
phia, Pennsylvania.
*<'At the present day one need
scarcely enlarge upon the etiologic as-
pects of this cause ; nor is it necessary
to enumerate the large number of dis-
eases that, in a broad sense, might be
placed under this etiologic heading.
Pediculosis, scabies, the irritation pro-
duced by bedbugs, fleas and mosquitos,
may be mentioned among the animal
parasitic affections, and tinea versico-
lor, favus, ringworm, among the veg-
etable parasitic diseases, to which could
be added numerous others due to the
lower micro-organisms, such as im-
petigo, furuncle, tuberculosis cutis,^
IqiofMy, etc. Afaiifthitp sbA uuadl iisive
proof as to the alleged cause and effect
is still wanting in connection with the
by far larger number of the diseases
presumably due to micro-organisms,,
but no one can deny their growing im-
portance in the etiology of disease,
and the great value of original investi-
gation in this direction.
''With the advent of this etiologic
element the subject of contagion has
naturally been pushed into the fore-
ground, and an expression of opinion
on this point in a particular disease is
often hedged about with difficulties.
While admitting the probable parasitic
origin of many diseases, and the infer-
ential deduction of communicability
that naturally follows, still observation
shows that in many instances, more
especially in those in which the dis-
ease is presumably due to the lower
organisms, contagiousness does not
seem to be even suggestively demon-
strated in practice— at least not with
any degree of certainty. In many dis-
eases, therefore, for which we even
now accept a parasitic factor, we must
assume that favoring conditions of the-
* Taken from "Treatise on Diseases of the Skin." Bjr
H. W. Stelwagon, M. D . page 84, 1902. Published hy
W. B. Saunders & Ck>., Philadelphia, Pennsylvania.
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ORIGINAL Articles,
systemic state or the local tissues ex-
ist, and without which the successful
invasion or pathogenic multiplication
of the micro-organism fails or remains
harmless. In short, I am fully in accord
with Professor Duhring^s opinion that
Hhese parasites usually require a pe-
culiar condition of the skin or soil for
their growth and development.' Even
prolonged exposure, unless conditions
are favorable, is in many such dis-
eases without result; this is fre-
quently demonstrated with such ordi-
narily actively contagious maladies as
ringworm ; and the vegetable parasitic
affection, tinea versicolor, judged by
clinical experience, is only in the rarest
instances communicated from husband
to wife or the reverse, and yet the
fungus exists in abundance and is
readily demonstrable. Nor, appar-
ently, is every person to the same ex-
tent a pei^sona gi*ata to even the more
active animal parasites — bedbugs, fleas
and even the louse and itch-mite, al-
though the last two are the least fas-
tidious as to the character of their
prey. Apparently some inherent pe-
culiarity of the skin or the odor of its
secretions measureably protects some
individuals against successful parasitic
invasion."
JAMK8 Kkyins Htdc, M. D., PfofoMor of Skin. Genito-
urinary and Venereal Diseases, Rush Medical Col-
lege, Chleago. niinois.
* Parasitic Diseases. — * 'Under this
title were once included solely the
dermatoses induced by the presence of
the animal and vegetable parasites.
Among the former may be named
scabies and pediculosis; among the
latter, ringworm of the scalp and of
the beard. But the term parasite has
■acquired a much wider scope since the
recognition of the micro-organisms
which have been demonstrated to be
efficient in the production of a long list
of cutaneous affections. Among these
may be named the bacilli productive of
cutaneous tuberculosis and of lepra;
*From "A Praetieal Treatise on Diseases of the
Skin." Fifth edition. By James N.Hyde, M. D. 1900
Published by Lea Bros. & Co., Philadelphia.
the pus cocci, responsible for the sev-
eral forms of impetigo and pustular
eczema; and the streptpcocci. recog-
nized in several forms of dermatitis.
In most of the dermatoses which are
recorded to-day as parasitic, germs
have been recognizcNl, which either
singly or in co-operation with others,
have been proved to be effective in the
production of these disorders, or have
been demonstrated to play an active
part either in their extension or ex-
acerbation.*'
John V. Shoimakkb, M. D., Professor of Skin Mid Vene-
real Diseases in the Medieo^AiroxEieal OoUege and
Hospital, Philadelphia, PennsylvanU.
***The development of bacteriolog-
ical research has inevitably modifi^
and enlarged our conceptions of the
etiology and pathogenesis of diseases
of the skin. It has been already
clearly demonstrated that many are,
either directly or indirectly, the re-
sults of infectious processes. It is
reasonable to assume that the list of
infectious dermat- 'ses will be extended
considerably from the investigations
constantly being earned on by numer-
ous and independent observers. Clin-
ical facts had already assured us that
cutaneous manifestations were in many
instances excited by the presence in
the blood of products of tissue change.
Being retained within the organism,
these substances have the power of
exciting diseases in the integument as
well as in other tissues. The eruption,
consequently, is but a part of a general
disorder, such as gout, rheumatism,
diabetes, syphilis, scrofula, or tubercu-
losis. These diseases are enirendered
by chemical compounds elaborated
within the body, and not necessarily
or always of microphytic origin. In
another class of cases the cutaneous
malady seems to depend upon the di-
rect action of micro-organisms which
have lodged upon the skin, and there
found a fitting soil for development.
It is probable that here, as elsewhere,
*Froto "A Praetieal Treatise on Diseases of the
Skin." By John V. Shoemaker, M. D. Fourth edition.
Published by D. Appleton & Co., New York. 1901.
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Present Status of Bacteriology.
the two causes are often conjoined,
and that, as a rule, the skin onlj
proves a fitting soil when its vitality
has been previously impaired bj causes
acting from within the organism. Ex*
temal agencies, also, such as heat,
cold, clothing, etc., have their share of
influence in preparing a field upon
which parasitic organisms may flour-
ish."
NoBMAN WAiJCKft> M. D.» f>BUow of Ihe Boyal OoUece of
Phytieiant of Edinburgh; Assistant PhysicUa for
DiseMM of th« Skin to tiio Royal Edinburgh In-
firmary, Edinburgh, Scotland.
***Infar too many diseases we are yet
ignorant of the actual infectious cause.
In others the probable causal relation of
some germ to the disease is widely ad-
mitted, while there are others which it
f , is only by analogy that we can consider
I infectious at all. It is not necessary
I that the cause of a disease shall be
present at the actual place where signs
I at irritation are observed microscop-
ically. Pai^sites of all kinds have the
power of exerting their influence at a
distance, and be the parasite gross, as
in the case of scabies, or minute, as in
the case of impetigo, the effects pro-
duced by its presence may be found in
localities remote from where the actual
parasite can be detects. This is what
is called chemiotaxis, the poison pro-
duced attracting the mobile elements of
the tissues. Thus, in certain pustular
affections of the skin, which are clearly
inoculable, the cause of the disease
will be found in a small colony of
gtftms situated only at the apex of a
considerable pustule, while the vessels
for some distance around show evident
signs of disturbance."
WtLHAU S. QoTTHViL. M. D., Physidan to the City Hos-
^tal; Dermatologist to Lebanon and Beth-Israel
Hotpitals, etc.. New York City.
Among all the momentous changes
of modem medicine, none has been
more radical and farther reaching in
its effects than the alterations of our
ideas as regards the etiology of dis-
•Prom "An Intvodnction to Dermatology." By Nor-
man Walker, M. D. 1899. Published by William Wood
A Co., New York.
ease. Dermatology has not escaped
this influence, and comparatively little
is now heard of the action of diatheses,
changes in the tissue fluids, psychic
effects, and other general and indefi-
nite causes in the etiology of derma-
toses. To a certain extent the change
is justifiable; in a considerable number
of ca^es we are now in a position
to point out the definite causative factor
of the disease in question. But in the
majority, including some of the very
commonest affections with which we
have to deal, we are still as much in
the dark as ever. We now, however,
usually have the courage to proclaim
our ignorance and say o)>enly that we
do not know, leather than to ascribe
these maladies to agencies of indefinite
and unprovable nature.
Light, heat, cold, mechanical and
chemical influences are the acknowl-
edged causes of a variety of skin
affections, including erythema solare,
erythema photo-electricum, lentigo,
xeroderma, hydroa, chillblains, burns,
corns, callosities, occupation derma-
toses, drug eruptions and others. In
another series of diseases an organic
factor of a fungoid or bacterial nature
has been found, and it is to these that
the present brief inquiry is to be di-
rected.
A number of dermatoses have long
been known to be caused by the pres-
ence of living organisms on or within
the skin. Epizoa like the pulex irri-
tans, pediculus and leptus auctumnalis
cause pediculosis. Dermatozoa, as aca-
rus scabei demodex folliculorum and
filaria medinensis, cause scabies, acne
and Madura foot. Hematozoa like the
filaria sanguinis hominis cause elephan-
tiasis and lymph-scrotum. Epiphyta
like the achorion Schoenleinii, tricho-
phyton, microsporonminutissimum and
microsporon Audouinii cause favus,
ringworm, eczema marginatum and
ptyriasis versicolor. Endophyta are
the actinomyces that occasionally affect
the skin, and the blast omyces that have
been recently proved to be the cause
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Original Articles,
of various granulomatos and ulcerative
affections.
Turning now to the purely bacterial
affections of the skin, we are con-
fronted with conditions which are un-
doubtedly unsatisfactory, but which
are inevitably in a department of our-
science which is undergoing its first
development. In a certain few cases
a bacterial cause for the affection in
question has been found, and has been
definitely proven to be the causative
agent. In others, again, though the final
proofs obtainable from inoculation are
still wanting, the parasitic agent has
been found with a constancy that ren-
ders its relationship to the disease cer-
tain. In a large number, however, the
results are as yet conflicting; some
observers find an organism, and others
do not; and different structures are
described by different investigators.
And in some affections that are un-
doubtedly bacterial, as shown by every
fact of their history, we are still en-
tirely wanting in anything like reliable
data as regards the organic agent that
causes them.
Among the external microbic causes
of skin diseases the staphylococcus is
probably the most important. A whole
series of dermatoses, clearly differen-
tiable clinically by variations of site,
depth of tissue affected and course, is
caused by it. All the pus affections of
the skin and its appendages, as well as
many varieties of disease from other
cause, are due to its primary inocula-
tion upon the skin, or its secondary
implantation upon already existent le-
sions. Impetigo, echthyma, furuncle,
carbuncle and panaritium are examples
of the first, as are impetiginous eczema,
ulcerating syphiloderm, and ulcerating
lupus of the second method of inocula-
tion. The staphylococcus causes ery-
sipelas, the Ducrey-Unna bacillus soft
chancre. The tubercle bacillus is the
etiological agent in a number of derma-
toses, including lupus vulgaris, tuber-
culosis cutis verrucosa, tubercular ul-
ceration and post-mortem tubercle.
Hansen's bacillus is recognized as the
etiological agent in leprosy, and the
rhinoscleroma bacillus is the cause of
the disease from which it takes its
name. Malignant pustule is caused by
the bacillus anthracis, and glanders
and farcy are due to the organism that
is so well known in veterinary medi-
cine.
Turning now to the maladies that
are probably microbic, but in which
the active agent has not yet been abso-
lutely demonstrated, we recognize
syphilis as probably the most import-
ant of the class. No reasonable man
can doubt the existence of a microbic
cause for this disease; I taught its
probability twenty years ago, when
bacteriological science was still in
its infancy. Yet of all the various
discoveries of the syphilitic organism
that have been proclaimed, not one,
from that of Lustgarten years ago to
that of Niessen in 1900, has been defi-
nitely confirmed. Other examples are
the eruptive fevers, for which the evi-
dence of microbic origin is almost as
strong as for syphilis. Variola, scar-
latina and measles have skin eruptions
of undoubtedly microbic origin, though
the etiological agent has not so far
been found. Diphtheria and typhoid
are in a class by themselves, for the
etiological factors have been found;
but their exact relationship to the
exanthems that sometimes accompany
these diseases have not been deter-
mined.
The list of possibly microbic skin
diseases a long one, and it seems prob-
able that many of them will be trans-
ferred to the proven class before very
long. The impression is gaining ground
that the "symptom-complex" which we
call eczema is, at all events for certain
members of the group of diseases, of
bacterial origin. The pathogenicity of
Unna's morococcus is, however, still
unproven ; but there seems good reason
to place much reliance upon the experi-
ments of Becker, Boeckbardt and Ger-
lach last year, who investigated the
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relationship of the staphylococcus and
its cultures to the disease. They found
that cultures containing the organisms,
but none of the toxins, caused impet-
igo, furuncle or abscess when inocu-
lated upon the irritated skin, but not
eczema. Cultures containing cocci and
toxins, and filtered cultures containing
the toxins alone, invariably produced
typical acute papular or vesicular ec-
zema. As stated in my recently pub-
lished review of the year's work in
dermatology in Progressive Medicine^
these findings are of great importance,
and, if confirmed, will undoubtedly
have a marked effect upon both classi-
fication and treatment of these diseases.
Of other possibly microbic skin diseases
I shall mention only lupus erythemato-
sus. There is some evidence that it is
caused by the tubercle bacillus, or its
toxines, like lupus vulgaris ; but it is
still entirely inconclusive.
144 West Forty-eighth street.
A. Ravooli, M. Dm Professor of Dennatology and Syphil-
ographr, Medical Department Cincinnati Univer-
sity, Cincinnati, Ohio.
These eruptions belong to a large
<5lass of affections of inflammatory
nature, acute or subacute in character,
easily relapsing. .
The skin is affected by a large num-
ber of micro-organisms, of which some
are specific and some non-specific, and
they can be divided in two groups : one
of the micrococci and another of the
bacilli.
The micrococci of non-specific nat-
ure are the most important; they are
the staphylococci and the streptococci.
1. Staphylococcus (Rosenbach), the
most prevalent of all, is represented by
small rounded elements, sometimes
isolated, oftener united. It develop-
readily upon the various culture media.
From the different color the staphys
lococci have been divided in three
varieties: Staphylococcus aureus, S.
citreus and S. albus.
It is still unsettled whether these
three staphylococci represent distinct
species, or if they are varieties of the
same species. From the fact that they
are often found together in the same
foci, and that from some culture ex-
periments staphylococcus aureus has
lost its chromogenic power and has
been transformed in white, has pre-
vailed the opinion that the three
staphylococci are only varieties of the
same species.
The staphylococci are found as
saprophytes in soil, water, ice, air,
dust, cloths, etc. When they attain
the rank of pathogenic agents they
produce suppuration. The chromo-
genic varieties are in general more
virulent than the white. The skin
offers a large field to the staphylococci
for their development. According to
the seat and to the activity of the
germs, the morbid results are of dif-
ferent intensity.
The diseases of the skin caused by
staphylococci can be grouped in ec-
zema, impetigo, folliculitis (sycosis
coccogenica), acne, furuncles.
In some cases, on account of the
virulence of the staphylococci and of
the liability of the skin, they are capa-
able of producing bullaa of the skin,
which we usually call ''dermatitis bul-
losa."
2. Streptococci observed by Coze
and Felz were isolated from erysipelas
by Felheisen are much smaller micro-
cocci, and they have tendency to
group themselves in chain. They are
easily cultivated in serum, either pure
to mixed with boullion, and in this me-
dium attain a high degree of virulence*
The streptococcus, like the staphylo-
coccus, is widely spread in nature: it is
found in the air, in water and in the
soil. It invades putrescible matters,
and is easily found on the skin and
constantly in the buccal cavity.
This microbe is much more virulent,
and produces edema, suppuration,
pseudo-membranes and gangrene.
The diseases of the skin resulting
from the streptococcus can be grouped
as follows: Erysipelas, folliculitis ma-
ligna (decalvans), carbuncle.
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ORIGINAL ARTICLES.
It is possible that other acute malig-
oant diseases of the skin with tend-
ency to gangrene are also caused by
the streptococci, but it has not yet been
proved. The streptococci are also of
different varieties, and show modifica-
tions in their biological characteristics
sufficiently marked. To these varieties
has to be attributed the difference of
intensity of the named affections.
Diseases of the Skin Due to Bacilli.
— Some are produced by the tubercle
bacillus (Kob B., which appears as a
non-motile rod possessing a strong
tinctorial reaction. It seems that the
tubercle bacillus in certain conditions
undergoes morphological modifications,
showing projections and ramifications
terminating in club-shaped swellings.
But so far it has no practical conclu-
sions. The tubercle bacillus is very
resistant and only with difficulty is de-
stroyed. It is widely spread among
the human race and animals, which
are, like the man, affected by this
dreaded bacillus.
Like any other tissue the skin is
frequently affected, and according to
the different anatomical structures pf
the skin, where the bacillus finds its
place, the affection has a different ap-
pearance. In the same time the skin
may be affected by the bacilli, and be
also affected by the toxinee, which are
the production of the bacilli hidden in
more deeper parts of the organism.
To the presence of the tubercle bacillus
we can refer the following skin affec-
tions: Lupus erythematosus, lupus
vulgaris, tuberculosis lui>oides, lichen
scrofulosorum, some cases of folli-
culitis, acne cachecticorum, ulerythema
sycosif orme, tuberculosis miliaris cutis,
tuberculosis verrucosa, erythema in-
duratum, tubercular ulcers.
Another specific bacillus is the bacillus
leprae, discovered by Hansen, which
causes leprosy, with its cutaneous
manifestations, which we know as
leprides and leproma.
Bacillus anthracis and bacillus mallei
attack also the skin, producing their
deleterious effects. In severe cases of
diphtheria the diphtheritic bacillus
causes ulcerations of the skin sur-
rounding the mucous membranes of
the nose, mouth and of the genitals.
Septic vibrio (Pasteur) or bacillus of
gaseous gangrene, which is also fre-
quently found in the soil, dung and in
the mud. When it is introduced in a
wound, produces a gangrenous spot,
which widely spreads on account of
the evolution of gas, which infiltrates
the surrounding tissues. The microbe
remains limited, but its deleterious
toxines produce general infection with
fatal end.
Next to the bacilli there are other
parasites of a higher order capable of
producing infectious diseases which
find their entrance in the skin. These
forms belong already to the fungi, and
are so-called phycomyces. The most
important is the streptotrix bovis, or
actinomyces, which is the cause of
actinomycosis in man and animals.
This fungus produces two different
appearances of the disease, one in form
of sarcomatous growths and another
in form of suppurating foci. In both
cases the characteristic yellow granules
are easily found, representing sub-
limated sulphur. Under the microscope
the mycilial filaments irradiating like
the spokes of a wheel are soon to be
found.
It is a facultative anerobic vegetable,
which lives as saprophytes upon the
graminaceas. For this reason the cat-
ties are frequently affected with this
disease.
Streptotrix Maduree is another fun-
gus, which produces the Madura foot,
a disease frequently observed in India,
Algeria and South America.
Recently have been described some
kind of fungi, which have been referred
to the blastomyceta, and to them Gil-
christ and Busse have attributed a
peculiar malignant form of dermatitis,
which they have called blastomycetic
dermatitis.
Coccidia and sporozoa have also been
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described as the factors of cancerous
growths, but so far no positive ob-
servations give us any right to call them
the true producers of carcinomatosis.
Gio. G. Mblvin, M. Dm St. John, N. B., Canada.
Having been requested by the editor
of the American Journal of Derma-
tology for a statement regarding the
above subject, it seemed well in com-
plying with his request to make that
statement as practical and, therefore,
as short and concise as possible.
It will be observed that this article,
in many respects, is very elementary.
This is unavoidable. In treating any
subject in its entirety many facts must
be recited which are elementary in
character, and this will be no excep-
tion, especially to those versed in derma-
tology. But, indeed, the writer makes
no claim to originality, his aim being
simply to gather together in as plain
a manner as possible the well-known
and acknowledged truths respecting
the subject in question.
Nothing herein noted will have ref-
erence to the obscure, ill-defined and
not-yet-sufficiently-observed lesions pe-
culiar to tropical climates, nor to that
multitudinous class of parasites pres-
ent in all lesions, whether upon the
skin or elsewhere, which have not been
proven to have an etiological relation
to the diseases in which they are found.
There is, also, another limit which we
will set ourselves. It is not proposed
to say anything of those parasites of
an animal nature and beyond micro-
scopical size, such as are the prime
factors in scabies or pediculosis. These
do not, properly, come under the head
of bacteria; that is to say, while bac-
teria are parasites, all parasites are not
bacteria.
So bounded, it will be found that
our subject is not nearly so extensive
as might, at first sight, be imagined.
In these days germs occupy a large
amount of the doctor's time and
thought. One or two very important
diseases, such as pulmonary consump-
tion, having been found, indubitably,
to be caused by living organisms, it is
quite natural that the suspicion of bac-
terial origin should attach itself to
nearly everything with which we come
into contact. Concerning the impoi't-
ance of deciding the origin of a dis-
ease, whether it be produced by germs
or not, there can be no question. In
the first place, all diseases, as a matter
of course, parasitical in their origin,
are by reason of such causation conta-
gious. This is very apparent. If a
certain germ cause a disease in one
person, then it is very plain such germ,
transplanted, may cause a like disease
in another, and the possibility of the
transplantation is always compara-
tively easy. Thus it was that phthisis
pulmonalis was removed from the list
of non-contagious to that of conta-
gious affections. Again, bacterial ori-
gin or otherwise is highly important as
regards treatment and prognosis.
Nothing is easier than to destroy life,
especially such low life as we usually
find in germs, if we can come into
actual contact with the parasite, and,
therefore, for this very reason, other
things being equal, a parasitic disease
has a better prognosis than a non-
parasitic one. Every one knows the
improvement in prognosis of phthisis
pulmonalis since Koch's discovery be-
came known. If, then, the etiology
as regards bacteria be so important in
constitutional diseases, where the germ
is generally hidden away in the depths
of the organism, it is very evident that
it becomes almost all-important in dis-
eases of the skin, which are, in general,
local and easily accessible.
In order to be as concise as possible,
and also for the sake of plainness, we
will tabulate in alphabetical sequence
those bacteria which, with the forego-
ing limitations, may be called specif-
ically pathogenic, and opposite to
them the names of the diseases for
which they are held responsible:
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Original Articles.
Parasite. Disease.
Achorion Schonleinii Tinea favosa (favus).
Bacillus anthrocosis Malignant pustule, anthrax, etc.
** lepra (Hansen) Leprosy.
^' tuberculosis Lupus vul^is.
Microsporon furfur Tinea versicolor.
^^ minutissimum Erythrasma.
Staphylococcus aureus et al bus. .Impetigo contagiosas.
C Tinea capitis vel tonsurans.
Tricophytina < Tinea barbae vel sycosis.
( Tinea circinata vel corporis.
I am well aware that in formulating
the above table I am treading upon ex-
ceedingly debatable ground. A host of
authorities, more or less reliable, are
ready to question it, chiefly in the way
of addition, but scarcely any two of
them would agree as to the exact num-
ber to be added. The above repre-
sents, therefore, all those micro-organ-
isms universally acknowledged patho-
genic in a dermatological sense. Some
of them, such as the staphylococci, are
responsible, probably, for more dis-
eases than they are credited with in
the table, such as furunculosis, etc.,
but these exceptions are neither nu-
merous or important.
It will be observed that they are not
all local in their effect. Leprosy is es-
sentially a constitutional disease, the
importance and certainty of its terrible
skin manifestations alone being respon-
sible for its bein^ classed as a skin dis-
ease. It will also be noted that the
range of germ diseases is compara-
tively limited, not only in number, but
to a far greater degree in importance.
Of the ten or a dozen diseases men-
tioned, only a few of them are of re-
ally practical interest. Compared with
these not yet, at least, proved bacterial
in origin, they sink almost into insignifi-
cance. Leprosy, fortunately, is a dis-
ease almost never seen in Anglo-Saxon
communities. Its bacillus was discov-
ered by Hansen, towards the middle of
the last century, and under the micro-
scope is scarcely to be distinguished
from that of pulmonary consumption.
except in its slightly smaller size. It
may also be added that the manner of
staining is identical. Its most likely
habitat is, especially in the earlier
stages, the discharge from the nose.
The bacillus of tubercule is too well-
known to need any extended reference.
Its importance, however, in lupus, is
very much less, diagnostically, than
in the lung disease. It is a matter of
some difficulty to differentiate it in the
lupoid tissue, but, fortunately, the
clinical features of this disease are so
pronounced that no one, if versed at
all in dermatology, may be excused in
overlooking it. In another place* I
have discussed the remarkable immu-
nity from phthisis pulmonalis enjoyed
by those suffering from L. vulgaris,
even when the latter is situated at the
very entrance to the respiratory tract.
It would project this article beyond a
reasonable length to attempt to de-
scribe in full the mechanism of pre-
paring the bacillus for examination,
nor would it be profitable, seeing that
such work is so much better performed
in text-books for that purpose, than
the writer could do it. As its name
denotes, it is a rod-shaped germ, six
or eight times longer than wide, and
usually, though not invariably, found
in clumps of half-a-dozen or so. The
bacillus of anthrax^ or malignant pus-
tule, was almost, or quite, the first
pathogenic micro-organism discovered.
It is consequently more than half a cent-
* See my article on skin muiifestatioiis in general
disease, in September 1902 issue, AUBBIoak joubkai.
OF DXBMATOLOOY.
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Present Status of Bacteriology.
11
ury old. It is among the longest of path-
ogenic germs, being found in straight
or broken rodis many times longer than
wide. It can, nearly always, be dem-
onstrated in any collection of pus re-
moved from the lesion, and under quite
a low power. The fungus of tinea
favosa is still more easily found. A
scraping from the affected scalp, con-
taining any infected crusts, softened
by and immersed in liquor potassse,
will distinctly show it with a No. 6 ob-
jective. Once seen, it can never be
mistaken for anything else, even for
that of the tricophyton, which it most
resembles. By its distinctly larger
size than the latter it is quite easily
known. Beside that, the clinical dif-
ference between favus and tinea ton-
surans is so pronounced that a mistake
would be inexcusable. Between the
fungus of favus and that of tinea ton-
su7'ans^ the chief difference, in appear-
ance, as already noted, is the greater
size of the former both in the diameter
of the spores and in the breadth of the
mycelium . Indeed, between the fungus
of favus, ringworm and erythrasma
there is no radical distinction except
size, but this is so pronounced, the
microsporon minutissimum being so
very small, that there should be no
difficulty in differentiating, especially
with the clinical cases before us. The
remaining fungus, that of tinea veri-
cdlor^ is essentially different in its dis-
tribution upon the microscopical field
from either of the other three. The
spores hang in clusters almost exactly
as grapes do on the vine, and for this
reason are very distinguishable, indeed.
All four are plainly seen in liquor
polassee, without any staining what-
ever. The staphylococcus aureits and
albus are simply pus-producing germs,
and although I have included them in
my list of pathogenic organisms, yet
their standing, as such, is still doubt-
ful. They are easily stained, as found
in pus, by most of the aniline dyes,
and are quite easily seen by a No. 6
lens. Having passed, in rapid review.
those germs which alone, with fore-
going limitations, are of importance in
dermatology, it is periiaps proper that
a few reasons be given for being thus
dogmatic in our assertions.
The chief disease which the derma-
tologist has to treat is eczema. Now, if
eczema were proved to be a germ dis-
ease, it would, by reason of its enor-
mous frequency, be a very important
fact. Indeed, such a germ would
easily outweigh, in importance, all the
others put together. But eczema is
not a bacterial disease, notwithstand-
ing frequent assertions to that end.
There is, indeed, a form of disease
called **parasitic eczetoa," which, in
its clinical characteristics, is appar-
ently germ-produced, even though its
specific cause has not been demon-
strated. But such disease is not ec-
zema. To call it such is a misnomer.
It is, until a definite name, consequent
upon its cause, be given it, a parasitic
dermatitis. A germ-produced disease
is contagious, as has already been
shown. Eczema is not. The former
is of gradual onset. Eczema, as I
have repeatedly seen, often envelops
the whole body in a few hours. Ec-
zema almost always is symmetrical,
while there is no possible reason for a
bacterial disease to be so. Eczema,
again, is often limited in particular per-
sons to asmall localized space, and, after
being cured, will recur exactly upon
the same spot, a coincidence which there
are a million of chances to one against
its happening if produced by a germ.
Time and again, also, has eczema been
investigated for pathogenic germs;
innumerable have been found, but
none, that when introduced into the
system, ever even simulates the orig-
inal disease. There are a few proofs
of its non-bacterial origin. Yet this
disease constitutes thirty per cent, of
all dermatological lesions.
Again, one of the most important,
and, unfortunately, frequent diseases
met with by the skin expert is syphilis.
Now, while there is no question as to
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12
Original Articles.
the contagiousness of this disease, yet
this contagiousness is not due to a
germ. The exhibition of iodide of
potassium will often produce an erup-
tion of the skin. But no one will
pretend to believe that pot. iodid con-
tains **germs." Again, the contents
of the poison glands of the cobra de
capella of India, will, when injected
into the system, produce inflammation
and death within a very few minutes.
The suddenness of its onset effectually
precludes the supposition that its fatal
effect is due to any micro-organism.
Almost innumerable instances might
be adduced in this connection. In a
word, there are other disease-produc-
ing elements residing without the body
other than germs, to the chief of
which, for want of a better, the name
virtis has been affixed. Nothing can
be more important than to keep in the
mind a clear distinction between them.
Yet nothing is easier, or more com-
mon, than to get them confused. It
must be admitted, however, that, al-
though we possess considerable knowl-
edge of the life-history and mode of
toxic procedure in the matter of germs,
we are yet in almost complete igno-
rance of the nature and method of ac-
tion of virus. Yet, in all probability,
it is to this subtle and powerful ele-
ment we owe the origin of syphilis.
The strongest argument against the
bacterial origin of syphilis is the un-
doubted and peculiar hereditary nature
of this complaint. Volumes have been
written to disprove this trait of syph-
ilis, but without conclusive effect. If,
then, to syphilis we add psoriasis, all
the so-called ' 'childish exanthemata,"
as measles, scarlet fever, etc., etc.,
pemphigus, nearly all the various ab-
normal growths and tumors, in none
of which, a specific etiological germ
has been differentiated, we shall come
to see, after all, the limited scope the
path(^enic, germ has in dermatology.
StilU as .hinted at the outset, this is
hardly a subject for congratulation.
It must be confessed, taking psoriasis
as an example, that the greater num-
ber of these non-bacterial lesions are
still sealed books to us, so far as
their origin is concerned, and the
not knowing the true genesis of a dis-
ease is a decided handicap to its treat-
metit and progress. However, there
is an advantage, and a great one, in
recognizing that in all probability it is
futile to look for germs or the true
etiological factor in many of these
complaints. The germ business, to
speak in a slangy way, has been, and
is being, greatly overdone. The old,
plodding, patient, painstaking pursuit
of original causes, other than material-
istic, has almost faded from earth.
The influence of that subtle and ob-
scure entity, which, for want of a
better name, we call the mind over the
body, and its power to cause diseased
conditions, has been relegated to the
limits of exploded superstitions, very
unwarrantably, in the opinion of the
writer. While undoubtedly disease is
not an entity in itself, just as undoubt-
edly it is not always caused by an entity.
I am not going to quote the hackneyed
extract from Shakespeare about *'more
things in heaven and earth," but it is
true, nevertheless. Let us hope that
a few of our great original thinkers
will leave the everlasting and sordid
chase after "bugs," and again take
up the more elevated and almost di-
vine contemplation of the influence of
"mind over matter."
o:*?o
*'In the application of therapeutics
to eczema, more is to be accomplished
by a careful study of the patient in
every aspect, and the application of
remedies suitable to the condition
found, than by the employment of any
special prescription which is supposed
to be of value in the disease."
L. Duncan Bulkley,
New York.
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Diverticula of the Male Bladder— Schmidt,
18
NOTES ON DBVBRTICULA OP THE MALE
BLADDER.
By Louis E. Sohmidt, M. So., M. D.,
Associate Prof esBor of Gtonito-Urixkftry Diseases, Chicago
Policlinic; Clinical Professor of Genito-Urinair Sur-
gery, School of Medicine, Northwestern Univer-
sii^j Attending Genito-Urinary Surgeon and
Dermatologist, Alexian Brothers'^Hos-
pital, Chicago.
Since this condition occurs so fre-
quently, is so often not diagnosed, or
is misinterpreted, and as it gives rise
to so many symptoms, I have thought
it justifiable to discuss this condition
before a general meeting.
While there is no absolute uniform-
ity of opinion in respect to the exact
nomenclature, it seems to be right to
distinguish between a diverticulum
proper and the so-called false divertic-
ula.
A true diverticulum is a cavity com-
municating with the viscus whose wall
consists of all or of a part of the con-
stituent layers of the bladder wall. It
is true, however, that in large divertic-
ula the wall is formed by the mucosa
and submucosa only. If this condition
affects a part of the bladder covered
by the peritoneum, the latter may
make a third layer.
Shallow recesses of the bladder wall
which are not attached to the bladder
as distinct and separate cavities may,
according to English, be called bladder
cells.
A false diverticulum is a sac which
originally had nothing to do with the
bladder wall, but is a pathological cav-
ity which by some cause or other came
into communication with the viscus.
For instance, perforation of a neigh-
boring abscess into the bladder, or the
establishing of a communication be-
tween the bladder and a tumor cavity
by ulceration.
Although it is true that occasionally
congenital diverticula are to be found,
the overwhelming majority of cases
are acquired conditions, and the state-
ment seems to be borne out by expe-
rience that cells and true diverticula are
practically only different stages of the
same process whose beginning depends
upon the same pathologic changes.
The first step for the formation of a
diverticulum is always a partial hyper-
trophy of the bladder wall ; and then
a consecutive weakening of a part of
the wall which is enclosed by hyper-
trophied muscular bundles; in other
words, the first stage of formation of
a diverticulum is trabeculization of the
bladder. It becomes quite apparent
how the causes for trabeculization
produce in the long run the bulging
out of circumscribed areas pf the blad-
der wall. The trabeculization of the
bladder, a partial work hypertrophy of
the muscular coat is always the result
of the overtaxing of the functional
capacity of the bladder. That is,
some obstruction in the urethra forces
the bladder to permanent, extraor-
dinary exertion for expelliAg the urine.
The usually concomitant conditions
of such an obstruction give impulse to
frequent urinary calls, so that not
only the force of contraction but also
the number of these exertions of the
bladder are increased. It is easily un-
derstood how the bladder wall in those
areas which are encircled by the hyper-
trophied muscle bundles will give way
under the pressure, when the bladder
contracts around its contents. But
even if this should not have been the
case the progressive hypertrophy of
the bundles which protrude into the
viscus will give the impression that a
sac with an open communication is
attached to the bladder wall. The en-
trance to these recesses will, of course,
be wide open, and as long as the mus-
cular coat does not give way, the depth
of these recesses will never be great*
The muscular coats will very easily
give way under two conditions. First,
if by inflammatory infiltration the mus-
cular coats in certain locations are
teased apart. Or if by an old inter-
stitial cystitis the larger part of the
muscular fibres in a certain spot have
been lost. In such a case the mucosa
and submucosa will protrude in and
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through thifi defeotive spot and into
the abdominal cavity like a hernia. A
pre-existing pericystitis by involving
circumscribed areas of the bladder wall
may also lead to the same condition.
It is to be observed that in the
course of time the size of the sac gets
out of proportion with its entrance, so
that a very small opening may lead
into a large diverticidum and there is
no limit to the growing size of the sac
but the elasticity and resistance of the
tissues. The shape of the opening
changes with the progress in the devel-
opment of the diverticulum. While at
first the opening is rhomboidal, outlined
by the sharp edges of the muscular bun-
dles, in time it acquires a more rounded
shape. The history of a diverticulum
accounts at the same time for the fact
that diverticula are almost never found
in the trigonal part of the bladder.
Here the bladder wall is supported by
underlying organs and the pelvic floor,
and strengthened by accessory muscle
bundles from the pelvic musculature.
The intimate attachment between the
different layers of the bladder wall in
this region is another factor which
militates against the formation of di-
verticula in this region. Different ob-
. servations convinced me, furthermore,
of the fact that the trigonum, on ac-
count of its topographic relations, is
possessed of a very limited contracti-
bility only, so that trabeculization of
this part of the bladder is never to be
found.
The cystoscopic view of divertic-
ula will, of course, vary according to
the stages of development. But one
thing is always characteristic. While
it is^easy to illuminate the fundus of a
shallow recess, and while its opening is
always of the same size as its bottom,
a true diverticulum, on account of its
bottle-shaped form, will, in most cases,
appear as a dark hole, because only un-
der certain circuraatances will it be pos-
sible to throw the light of the cyst-
oscopic lamp into the sac.
The symptoms caused by diverthAflft
are in quite a number of cases covered
by the symptoms which are the conse-
quence of the pre- and co-existing dis-
turbances in the urethra and bladder.
But there area few points which always
lead to the suspicion of the existence
of diverticula, and consequently force
upon us the necessity of a cystoscopic
examination. If it occurs repeatedly
that in flushing out the bladder sud-
denly, after the fluid had returned
quite clear, a big drop of yellowish
mucus appears ; if the patient reports
that the last drops of uriBe always
smell rather offensively; if a patient is
the bearer of a dull pain in the hypo-
gastric region without showing any defi-
nite symptoms accounting for it, the
presence of one or more diverticula
may be suspected. In some cases of
old chronic cystitis, in which silver
nitrate was applied for some length of
time, a quite characteristic occurrence
is frequently observed . Either the pa-
tient reports that once in a while after
he has finished urinating a blackish
fluid was voided, or, if it occurs during
a treatment, that the returning fluid is
of a blackish tinge, we may safely as-
sume that this originates in the fact that
some of the silver nitrate solution re-
mained retained in a bottle-shaped
diverticulum . A chemical test for this
emptied fluid will reveal the presence of
silver. Similar phenomena may occur
after the use of iodoform emulsions.
A quite characteristic complex of
symptoms arises if the formation of a
diverticulum is combined with the ex-
istence of peri-cystitis, while uncom-
plicated peri-cystitis causes a permanent
dull pain outside of the usual region
of bladder pain. This pain becomes
very sharp in the last-mentioned com-
plication . The patients call it a piecing
one, and this excessive pain is confined
to a distinct spot. The location of this
pain tallies with the location of a diver-
ticulum. The pain is always started by
micturition — that is, a sharp pain arises
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Diverticula of the Male Bladder—Schmidt.
lo
every time when the contracting blad-
der makes the diverticulum pull with
its top at the peri-cystitis focus.
The dignity of diverticula becomes
yetj apparent if we consider the con-
ditions in chronic cystitis which, as a
rule, accompanies the presence of
diverticula, the cystitis being produced
by the same infection which gave rise
to the development of strictures in the
urethra, or developed later on in con-
sequence of chronic retention and sub-
sequent infection. The diverticulum
will be a receptacle in which the prod-
ucts of the cystitis will always be re-
tained for some length of time, so that
they will adhere to its wall, thus giving
rise to decomposition.
Larger diverticula become very im-
portant, if such a sacculation becomes
attached to an inguinal or femoral
hernia. The descending hernia, by
and by, drags the diverticulum into the
hernial canal, and then quite serious
phenomena of incarceration might
take place, even if the prolapsed intes-
tine proper does not become impacted.
In such a case a diverticulum is very
apt to become gangrenous, and urinary
infiltration and fatal infection quickly
take place.
The diagnosis in such cases may be
a very difficult one. While, if a part
of a bladder which carries no diverticu-
lum becomes entangled into a hernia,
we have decided and leading symptoms,
this is not necessarily the case if a
diverticulum descends with a hernia.
If symptoms of incarceration take
place, the attention misht be drawti
to the possibility of the impaction of a
diverticulum through the following
facts: The urinary calls become fre-
quent, the contraction of the bladder
eictremely painful, and blood may ap-
pear in the urine.
Quite important conditions might
arise if the formation of a calculus
should take place inside of the diver-
ticulum.
The chronic retention in a diverticu-
lum leads quite easily to precipitation
of the urinary solids, while the organic
skeleton for the formation of a calcu-
lus is furnished through the existing
cystitis. If once the nucleus of a cal-
culus is deposited in the diverticulum,
the further deposition of urinary salts
will be a rather rapid one on account
of the already mentioned chronic re-
tention. The same holds good if a
renal calculus, after its descent from
the kidney, gets caught in the diver-
ticulum. This is proven by the fact
that cuts through stones taken out of
diverticula show quite frequently that
the nucleus is formed from substan-
ces which are only precipitated in
the kidney. These diverticula stones
remain quite often permanently im-
bedded, at least with the bulk in
the diverticulum, and by and by,
through permanent deposition, grow
out of the sac into the bladder viscus.
The attachment of mucus and pus
covers the free surface of such a
stone quite often so completely that
this condition gives rise to all kinds of
fallacies in diagnosis. All these cir-
cumstances explain why a stone in the
diverticula may, for some time, not
furnish at all the characteristic symp-
toms of a vesical calculus. The classic
symptoms of stone appear only after
it surpasses the level of the diverticula
entrance, or in case it becomes dis-
lodged by some sudden force.
The diagnosis of a stone in a divertic-
ulum faces the peculiar difficulty due
to the above explained conditions. The
stone searcher may not reach the stone
at all, or gliding over the free surface,
which is covered with pus and mucus,
it does not communicate to the ex-
amining hand the sensation character-
istic of the contact with a calculus.
The greatest aid in diagnosing such
stones is furnished by the cystoscope.
If a certain spot in the field of view
should not be quite free from all doubt-
ful appearances, the operative cysto-
scope can be resorted to. With an
introduced sound the questionable
prominence may be touched. With a
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curette the covering may be removed.
With the forceps the prominence can
be grasped, and it is thus possible to
find out whether a part of it is sunk
down deep into the bladder wall and
whether it is possible to dislodge the
stone.
The therapy so far as diverticula and
the conditions of the mucosa inside of
them is concerned, faces very difficult
propositions. As has been mentioned,
it is extremely difficult, if not impossi-
ble, to clean out deep diverticula by
flushing out, so that it is very hard to
bring the disinfectant or astringent
fluid in contact with the diseased
mucosa. We can overcome this diffi-
culty if diverticula are not too nu-
merous by direct local applications
through the operative cystoscope. It
is a matter for further experience and
tests whether the pumping apparatus
devised by Eraus will prove itself ex-
pedient for cleaning out diverticula.
It has been repeatedly suggested, espe-
cially by French authors, that exten-
sive diverticula be resected by lap-
arotomy, following the resection by im-
mediate suturing of the excision wound.
I personally have no experience in
this direction. The combination of a
diverticulum and an inguinal or femoral
intestinal hernia points quite strongly
to the resection of the prolapsed
diverticulum. Its excision and com-
plete suture will recommend itself
in non-inflamed cases. Gangrenous
diverticula will call for drainage after
the necrotic parts have been removed.
I would like to mention, that we must
always think of the possibility that
part of the bladder may be involved in
a hernia if the conditions, after expos-
ing the sac, are not quite clear, if a
great amount of preperitoneal fat ap-
pears, and if large veins en masse ap-
pear at the median aspect of the hernia.
This possibility will become a certainty
if the characteristic muscle bundles of
the bladder come in sight. After a
stone in a diverticulum is diagnosed
the therapy will be indicated by the
possibility of dislodging the stone,
either by bimanual manipulations or
through the aid of the operative
cystoscope. It will be best to proceed
with litholapaxy provided that no other
contra-indication exists, if it can be dis-
lodged. In case it should be impossi-
ble to dislodge a stone the only indi-
cated operation will be a cystotomy.
CLINICAL REMARKS ON SOME ADVANCED
FORMS OP URETHRAL STRICTURE
TREATED BY A COMBINED
URETHROTOM YAND
PERINEALSEC'
TION.
Bt Reginald Habrison, F. R. C. S., England,
Surgeon to St. Peter's Hospit*], London, England.
In some clinical remarks I recently
offered* on the commoner forms of
urethral stricture, I reserved for sep-
arate consideration certain instances
where the methods of treatment then
referred to were unlikely to prove of
much benefit for the reasons that
either the obstmctions were too "burn-
soar"-like and contractile to dilate or
too tough or extensive to divide from
within the urethra. In addition to
such characteristics the strictures are
not unfrequently complicated with
fistulee or tortuous routes in the per-
ineum and scrotum through which both
urine and pus escape. Hence the dis-
comfort of the patient is often greaUy
added to. Cases answering to this de-
scription are generally regarded as
being best treated by some form of
perineal section or, as it is sometimes
called, external urethrotomy, and it isto
this point I desire nowtoconfinemyself .
As a contribution to this subject I
published a series of casesf where the
usual operation of perineal section as
undertaken for stricture in the deep
urethra had been greatly simplified
and its safety and efficiency increased
by combining with it internal urethrot-
•The Lancet, April 23, 1898.
t Brit. Med. Jour., July 18. 1885.
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Urethral Stricture—Harrison.
17
omy. Strictures of the class now
under notice are but rarely impassable
to some form of instrument, and as by
reason of the urinary fistulae which so
often complicate them they are seldom
urgent in their nature, time is allowed
not only for effecting an entrance into
the bladder by the natural way, but
also for ascertaining what may be the
outcome of some kind of dilatation.
Assuming that the former is accom-
plished, though dilatation proves fut-
ile, the combined operation probably
offers the best solution of the difficulty.
In describing it, together with such
modifications as I have adopted since
the publication of my first paper on
this subject, I will take in illustration
two typical instances in which it was
employed.
Case 1. — ^A man, aged fifty-one
years, whom I saw and operated upon
in 1890 had been the subject of a
stricture with a strong tendency to
contract for some years and had un-
dergone no less than six operations
for it, including a divulsion by Holt's
method and five internal urethrotomies
at various intervals and places. For
some months before I saw him the
stricture had been contracting and
closing in spite of the patient's well-
directed efforts with suitable bougies
to keep it open. Straining to urinate
was constant and prevented continuous
sleep, and there was some cystitis with
probably pyelitis. It was clear that a
free relief must be afforded as struct-
ural kidney complications appeared
imminent. I performed an internal
urethrotomy with Teevan's modifica-
tion of Maisonneuve's instrument, as
I thought that the latter might not
stand the strain put upon it by the
cartilaginous character of the tissues
which had to be divided. This being
done I passed a full-sized grooved staff
^No. 12 English) into the bladder.
As the latter was evidently gripped in
the deep urethra I had the patient
placed in the lithotomy position, and I
divided in the median line from with-
out inwards such contracted tissues as
remained. I thus opened the urethra,
and found by passing my finger first
into the bladder and then hooking it
forwards. along the urethra in the di-
rection of the penile orifice that the
walls of the canal had now been ren-
dered free and unresisting. A full-
sized gum-elastic drainage-tube (such
as I have elsewhere described and fig-
ured$ in connection with the larger
subject of bladder drainage) was passed
into the bladder through the wound
and retained. The parts were well
washed out with a solution of per-
chloride of mercury (1 in 6000). The
drainage-tube was finally withdrawn
on the sixth day and the wound soon
closed. Eight years have now elapsed
since this operation was practiced.
The patient remains in good health,
and suffers no further inconvenience
from his urinary organs than having
occasionally to pass a full-sized bougie
for himself. I frequently meet him.
Case 2. — This patient, aged forty-
. five years, had a tough contractile
stricture which had resisted dilatation,
and was complicated with several uri-
nary fistulse of two years' standing. I
operated upon him in 1892. He was
treated in the same way as the preced-
ing patient, and in addition the various
fistulae were opened up and scraped.
The result was equally satisfactory
and is so far permanent.
Perineal section carried out on these
lines has been found to present many
advantages. In the first place it is
easier to effect a division of the hard
and condensed tissues of the perienum,
such as generally surround strictures
of this kind, upon a fairly large staff
than upon a small one or even upon
the shouldered staff which Syme used
for marking the commencement of
the contracted portion of the canal.
The freedom or otherwise with which
the large-sized instruments move in
the canal is sufficient to determine
t Surgical Dlsorderi of the Urinary Organs, 4th edi-
tion.
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the necessity for proceeding at once
with the external section, as well as
the precise locality and d^ree of the
contraction which remains. It may
seem at first sight in combining these
two operations that the magnitude of
an ordinary perineal section is in-
creased. This, however, is not the
case, as the division of more or less of
the obstruction from within the canal
has not infrequently proved sufficient
to completely clear the urethra, whilst
it invariabfy tends to lmit:cansiderably
the extent of any extern^ seetion
which may still be required. Further,
it must be rmtmwbaeed that there is
no kind of wound involving the deep
urethra which heals so kindly or is so
free from those constitutional symp-
toms which occasionally follow opera-
tions on this canal than that where a
temporary drain is established for the
urine. Again, this point is import-
antly supported by the results follow-
ing rupture of the deep urethra from
external violence. Cases of this kind
where a perineal section is performed
and a temporary drain established
compare most favorably, both imme-
diately and remotely, with those where
the treatment consists in the retention
of a catheter, when this can be passed,
the points of distinction being in the
former class of cases the absence of
septic symptoms of a serious nature
and the more favorable character of
the scar which results. There is no
worse kind of stricture to manage than
that following an extensive rupture of
the deep urethra and its treatment by
what may be described as the closed
method. It is on grounds such as
these that I believe the combined op-
eration proves of much benefit in the
treatment of some of the most serious
and complicated forms of urethral
stricture.
Before concluding these remarks I
will briefly refer to a class of strictures
which I have only incidently noticed.
This is the structurally impassable
stricture— impassable alike to instru-
ments and urine, and associated invari-
ably with an extraneous route for the
urine, probably through the perineum.
The latter condition is the result either
of nature's effort to provide escape f pr
the urine by abscess and fistula or of
the surgeon's, more promptly and di-
rectly, by incision. In endeavoring to
restore a urethra Oi this kind and to
close a well-worn fistula tke surgeon
will fully recognize the mechanical and
physiological difiiculties before him
not only in reproducing a portion^of the
canal which to all intents and purpose^
is obliterated, hut in subsequently fit-
ting it to take up the functions coQ'-
nected wttii the process of . natural, or
even aided, mieturitioci. It requires
no great amount of surgical ingemrity
to establish the continuity of the
urethra so far as instrumentation is
concerned, but to secure a reasonable
degree of control or influence over th^
restored portion of the canal is by no
means certain. On the other hand,
experience and trial have not infre-
quently shown that a good urinary
fistula has proved an excellent substi-
stute for a bad urethra.
Lower Berkeley street, W.
BSDOVBSICAL SURQBRY WITH SPECIAL
REFERENCE TO CYSTOSCOPY AND
URETER CATHETERISM.*
Bt F. Kriissl, M. D., Chicago, DlinoiB,
Professor of Genito-Urinary Surgery, Chicago Clinical
School.
It is but natural that with the earlier
progi*es8 made in the surgery of the
kidney and bladder the necessity of
rendering the diagnostic means more
exact and therapeutic procedures less
complicated and risky became more ur-
gent. As the first step in this direc-
tion — notwithstanding previous at-
tempts — may be considered the explo-
ration of the female bladder and the
removal of foreign bodies, stones and
tumors from the viscus after rapid di-
* From a paper on the program of the meeting of the
niinois State Medical Society.
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Cystoscopy— KREIS3L.
19
latation of the urethra practiced by
^moD. But this forcible distensiouis
not a^^Hnld, insignificant procedure, as
it requires general anesthesia, fre-
ouently produces deep lacerations of
iveilafisues, and from there quite pro-
fuse hMMMi^ges and ocoasionaliy re-
sults in irrepMM^wpontinence. The
desire to explore the^tMlies and the
renal pelvis, and the necessity it^ym
tect the former in abdominal and vi^
inal sections, led to epicystotomy and
colpocystotomy as a preliminary step
for the subsequent catheterization of
the ureter.
Pawlik, in Vienna, accomplished the
same result per vias naturales, using
the outlines of the ligamentum inter-
uretericum in the vaginal wall as a
guide to the vesical opening of the
ureter and afterwards constructed his
cystoscope, which permitted the in-
spection of the illuminated bladder and
the catheterization of the ureter without
difSculty. He was soon followed by
Kelly in this country with a similar in-
strument, the publication of the. latter
causing a bitter fight for the priority
in the invention carried on in med-
ical journals here and abroad for a
time. However, Howard Kelly has
done so much for the development of
intravesical surgery in America since
then that any unintended trespassing
on Pawlik' s invention may be par-
doned.
Simultaneously with the remarkable
progress in renal surgery in the last
decade, the surgeons felt the import-
ance and necessity of much exacter
methods of diagnosing surgical dis-
orders of the kidney and of informa-
tion regarding the presence, situation,
condition and functional capacity of
the other mate. The result furnished
by palpation and urinalysis proved fre-
quently unsatisfactory or unreliable
and misleading, necessitating as here-
tofore explorative operations. To ob-
viate the latter various apparatus have
been constructed, aiming to collect the
urine of both kidneys separately as it
enters the bladder. Among many I
may only mention the segregators de-
vised by Neuman (Deutsche Medioin'
ische WochenschHft^ 1897), and by
Harris {Journal AmericanMedical A$-
sociation^ 1898), and A. J. Downes^
in Philadelphia. The underlying prin-
ciple is the establishing of two separate
sections in the lower bladder wall by
means of an artificial septum. Each
iSiMiMi is supposed to contain the vesi-
cal openta|^itf4li»^K)rresponding ureter,
and from each one tbe " wimu ifr taken
by suction and collected in septtr^te
receptacles for further tests. The ad^
vocates of this method claim in its
favor that it does not require any spe-
cial skill, nor illumination of tbe blad-
der or searching for the ureteral open-
ing, the absence of any danger of
ureteral lesions or infection, and t^at
it allows simultaneous observations and
comparisons of the quantity of the se-
cretion of both kidneys in a certain
period. Objections are also not lack-
ing, and it is a fact that misleading
conclusions arrived at by this method
have been followed by grave conse-
quences. It is difficult to establish
with absolute certainty the watershed
in the male bladder, impossible in hy-
pertrophy of the prostate and in a
bladder whose shape is rendered irreg--
ular by any pathologic condition out-
side, but close to its wall ; for instance,
tumors and pericystitis. Errors and
doubts in tracing symptoms to the
bladder, instead of to the kidney, and
vice vei'sa^ are also possible and have
occurred. Rose's procedure for the
same purpose (C,f. Gyn.^ 1897), in-
tends to eliminate such errors. The
patient, female, is placed in the knee-
chest posture, a speculum 6 ctr. long
and 1 ctr. wide, introduced into the
bladder, and having found the ureteral
opening by using reflected light, the
vesical end of the tube is pressed
against the surrounding bladder wall,
and the urine accumulating in the tube
removed by suction. There is no doubt
that all these procedures are accompa-
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90
Original Articles.
nied by more or less inconvenience and
pain to the patient, that the pressure
exerted on the urethra, bladder and
surrounding organs is not without eon-
sequence and their efficiency a rather
limited one. The claim that the inex-
perienced is able to perform them is a
rather weak excuse for practicing them
in a period in which cystoscopy has
become a well-developed branch of
urinary surgery. Catheterization of the
ureters through the cystoscope, appli-
cable alike in both sexes, is in the
hands of the experienced ones a com-
paratively mild, painless and harmless
act, it often permits not only an exact
diagnosis of the diseased kidney, but
furnishes valuable information con-
cerning the presence, condition and
functional capacity of the mate.
The condition of a kidney still hav-
ing secretory tissue might make its
removal urgent, and yet its mate not
being essentially diseased, might have
such a low functional capacity as to
render it incapable of assuming the
work for both, and the surgeon will
refrain from a radical operation.
In another case the findings may be
such as to indicate that both kidneys
are similarly afflicted; that one has
none, or hardly any, secretory tissue,
while the functional capacity of the
other is still intact. Here the surgeon
will perform the radical operation with
a good prognosis, and to the relief of
the patient. Instructive is a case re-
ported b}' Casper, in which a tumor of
the right kidney was present, but the
urine furnished by this kidney was
perfectly clear, containing traces of
albumin, while very bloody urine came
from the left kidney. Such conditions
are found in tumors and tuberculosis
of the kidney.
Among the instruments for ureter
catheterization I mention the cysto-
scopes of Nitze, Casper, Albarran,
Kelly, Brenner and B. Lewis.
Our knowledge along the line of
functional diagnosis was materially in-
creased of late by the methods known
as kryoscopy, the Phloridzin test and
the determination of the quantity of
secreted urea, aided by the ureter-
catheterism. Credit for these innova-
tions must be given to Koranyi, Kuemel
and Casper. The latter ascertained
that the values for the quantity of
sugar and N, and the freezing point of
the urine of a healthy person when
collected from both kidneys simulta-
neously and separately are invariably
equal, but that all values in unilateral
kidney disease fall below the values of
the healthy one. This difference is so
pronounced that errors are nearly pos-
itively excluded, so that the determi-
nation of these values, taken together
with all the other methods of investi-
gation, lend a formidable support to
the diagnosis, prognosis and surgical
intervention in various kidney diseases.
With the possibility of a much earlier
diagnosis, we may now hope that the
mortality after kidney operations,
which has been materially lowered by
the wonderful strides in surgery, will
be still considerably reduced by the
combination of uretercatheterism, ra-
diography and the new methods of
functional diagnosis.
But the catheterization of the ureters
was not only the stepping stone to a
more solid basis in diagnosing kidney
diseases, it has also contributed to en-
large our therapeutic possibilities in
pathologic conditions of the ureter and
the renal pelvis through the cystoscope,
opening still brighter prospects for the
future.
Few as the records in this respect
are, yet the results obtained are very
encoui*aging, and they demonstrate the
feasibility of successful, bloodless, in-
travesical intervention for the relief
from an obstruction in the ureter by
concrements, valves or structures, and
the treatment of an infectious process
in the renal pelvis. All this, of course,
under especially favorable conditions.
The bulk of these cases will, as here-
tofore, be subject to cutting operations,
although catheterization does in many
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Cystoscop y—Kreissl.
21
cases aid the surgeon by indiciiting
where an incision has to be made, and
in a few others facilitate and simplify
the subsequent operation. We succeed
in temporarily emptying a hydrone-
phrosis or pyonephrosis by uretercathe-
terization, but the direct cause of these
conditions are such as to require a cut-
ting operation for their permanent re-
moval. We may dilate a stricture of
the ureter, but the character of these
coarctations frequently demands a
bloody division for a radical cure.
Two cases are on record in which an
intractable fistula remaining after ne-
phrotomy was finally closed by leaving
the catheter in the ureter and renal
pelvis for weeks without injury to the
tissues.
With the ureteral bougie we can oc-
casionally loosen a stone of small size,
replace it into the renal pelvis, or
facilitate its passing into the bladder
cavum, and in this way simplify the
subsequent operation — nephrotomy,
lithotripsy, etc. — for its final removal.
Very promising is the combined em-
ployment of the uretercatheter and the
radiography devised by A, B. Johnson,
in New York, a year ago, and by Felix
Loewenhard, in May, 1901. A flexi-
ble lead stiletto, inclosed in the ureter-
catheter is passed into the upper urinary
ways, and its exact location brought
into plain view by a subsequent x-ray
exposure. The advantages of this
method are obvious 'at once. We are
enabled to see the anatomical route of
the normal ureter or any deviations,
deflections and inflections, we also can
graphically locate the point of an
eventual obstruction and decide upon
the choice for the subsequent opera-
tion. The diagnosis of the unilateral
double kidney and of the horseshoe
kidney is also facilitated.
This method, indorsed by Tilden
Brown at the meeting of the American
Associat. of Gen.-Urin. Surg., April
30, 1901, has also met with the sym-
pathy of the West, judging by a hasty
•♦preliminary" notice to the prof ession
l)y two Chicago physicians at the meet-
ing of the Am. Med. Assoc, June, A.
C, and in Casper's Monatsbeinchte
fuer Urology^ in August, A. C.
I call the ureter catheterization endo-
vesical surgery in a broader sense, be-
cause the starting point for its appli-
cation is the bladder, and the latter is
the only route through which bloodless
surgical manipulations pass in the up-
per urinary ways. The endovesical
surgery of the bladder proper is as
old as the lithotripsy and the removal
of foreign bodies from the bladder
cavum ; they are procedures represent-
ing the typical bloodless, or nearly
bloodless, operations whereby the in-
tegrity of the bladder wall and sur-
rounding tissues remain undisturbed.
The great advancements in this partic-
ular branch of surgery are of a more
recent date, inaugurated by the cysto-
scope, and in particular by the opera-
tion cystoscopy, notwithstanding the
older and inadequate straight endo-
scopic tubes. As an auxiliary diagnostic
means in surgical diseases of the blad-
der, the cystoscope is of incalculable
value, a fact so generally - recognized
to-day that it would be an insult to the
practitioner to more than mention it.
Less appreciated by many, yet, on the
other hand, overestimated by some, is
the efficiency of the operation cysto-
scope, whose best representatives are
the instruments of Nitze and Casper.
Another one is Latzkos' instrument, in
which the various appliances like cu-
rets, scissors, forceps, snare and cau-
terizer are entirely separated from the
cystoscope, are consequently of larger
dimensions at the vesical end and in-
troduced in the bladder before the
former. This arrangement allows more
freedom in handlingthemintheviscus.
It has the disadvantage of all similar de-
vices which, exclusively designed for
the female bladder, are a copy of Bren-
ner's uretercystoscope, andNitze's op-
erating instruments, it is, according to
my experience, too short for the male
urethra.
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The employment of Casper's instru-
ment permits the crushing of smaller
concrements, while with the snare of
Nitze's instrument pediculated tumors
can be removed, and the base cauter-
ized, sessile neoplasms can be burned
down, ligatures and other small foreign
material are easily removed without a
cutting operation. Ulcerations of the
bladder- walls of various origin stub-
bornly resisting local medicinal treat-
ment can be brought to rapid epithelia-
lization by curetting and cauterizing.
All these procedures are carried out
under local anesthesia in an illuminated
organ, controlled by the eye; in most
of them the loss of blood is nil or in-
significant, and rest in bed not required.
Larger tumors and extended ulcera-
tions will, as heretofore, be subjected
to cystotomy, notwithstanding the few
cases on record in which Nitze, for in-
stance, succeeded in removing a large
tumor piece wise in fifteen and more
**sitting8." Such procedures cannot
be practiced without damaging results,
especially in men, by biiiising the
prostate and vesical neck and the re-
flex action upon the kidney. Cystotomy
has to be considered as the more radi-
cal and milder intervention in these
cases.
Last, but not least, among the endo-
vesical surgical procedures, I wish to
place the galvanocaustic radical treat-
ment of prostatic hypertrophy, com-
monly known as Bottini's operation.
As it was originally and still is per-
formed quite frequently, it cannot
strictly be called an intravesical opera-
tion, the cauterizing blade being drawn
from the bladder cavura downwards
into the prostate. But the new cysto-
scopic prostate incisor designed by
Freudenberg and Bierhoff puts the
operation on the same level as the cyst-
oscopic manipulations in the ureters,
and means a progress in this method
of dealing with the hypertrophied
gland. While previously we had to
rely upon the sometimes deceiving
sense of touch alone, we are at present
in a position to place the cautery blade
exactly to the point desired, and the
objections raised against this method
as being unsafe and dangerous because
of working in the dark are now without
foundation. Those who^ like myself,
have performed a great many of these
operations with the old instrument, and
had occasion to use the new cystoscopic
incisor, will readily appreciate its supe-
riority in appropriate oases. Trouble-
some, to be sure, is the hemorrhage
following the introduction of the some-
what voluminous instrument, which
interferes with a good view of the pro-
trusions.
In enumerating the methods and ap-
pliances employed in intravesical sur-
gery, I have given consideration to
most of the best known. I am fully
aware I could have mentioned various
others, but did not do so partly because
this would have gone beyond the limits
of the subject of my article, partly be-
cause many of those not mentioned
have to be classified as more or less
ingenious imitations or as mere play-
things. Summing up what has been
accomplished in endovesical surgery,
we can readily see that cystoscopy had
a great influence upon increasing our
diagnostic and therapeutic faculties in
bladder and renal surgery, and that,
vice versa ^ the demands of the steadily
advancing surgery of the bladder and
kidney acted as a stimulus for the im-
provement in cystoscopic technic and
diagnosis. It cannot be expected that
the endovesical surgery will displace
all other surgical procedures, but it
certainly has somewhat narrowed the
limits of cystotomy already, it has
gained a broader field for itself in the
bladder by simplifying the therapy
therein, and it has to be wished that it
might show itself just as successful in
renal and ureter surgery.
92 State Street.
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Epicarin as an Antipruritic— Reichmann.
28
BPICARIS AS AN ANTiPRURtTIC.
Bt Max ReiohmaNN, M. D.» Chleago, 111.
'^The most striking feature of ep-
icarin is its property of causing su-
perficial exfoliation of the epidermis,
which is often, although not always,
accompanied by a slight exudation
from the cutaneous vessels. The use
of the drug is, therefore, indicated in all
cases in which such an effect is desirable.
This effect, in connection with its anti-
parasitic influence, renders the drug of
service in dermato-mycosis and in
scabies."^
With these words Professor Kaposi
recommended epicarin, a condensation
product of creatinic acid and beta-
naphthol, which, aside from its com-
plete odorlessness, has the advantage
of being absolutely nontoxic, and what
is of great practical importance, of be-
ing stainless in its application. Kaposi
employed the remedy especially in
cases of scabies and regarded it as
preferable to hetanaphthol (which he
also was the fir^t to introduce into the
therapeutics of this affection), more
particularly on account of its nontoxici ty
and cleanliness. Other observers have
tested the drug and have reported
satisfactory results. Thus, for in-
stance, Pfeiffenberger* has used ep-
icarin in scabies ; Kraus^ in cutaneous
affections in children attended with
itching ; Rille* ^nd Siebert* in scabies,
while Winkler^ extended his experi-
ments to prurigo and seborrhea capitis.
During the past two years I have
resorted to epicarin in all itching af-
fections of the skin which came under
my observation, and in the following
will briefly describe various cases in
which its antipruritic effect was dis-
tinctly manifested.
Case I, Scabies. — The family of H.
L., consisting of three adults and five
children. In the fall of 1901 the
father and his eldest son presented
themselves with a cutaneous affection
which had attacked the son about four
months previously and ^adually had
spread to the other members of the
family. The son showed marked
eczematous lesions on the hands, legs,
and gluteal region, besides distinct itch
burrows. The latter were particularly
well developed in the father, who had
been the last to acquire the disease.
In the other members of the family
the diagnosis of scabies €ould also be
readily made, and I prescribed three
applications of a 10 to 15 per cent,
epicarin ointment, to be followed by a
warm bath. Immediately after the
first inunction the itching subsided.
Only the youngest child, about five
years old, presented slight dermatitis,
which, however, disappeared after the
application of oxide of zinc ointment.
The eczema of the oldest son was cured
in a short time by means of Lassar's
paste, with the addition of salicylic
acid.
Case II, Lichen ruber plantis. — Mrs.
H. W. had suffered since three years
with a constantly recurring cutaneous
affection, which lately had been partic-
ularly disagreeable on account of the
marked itching. Over the right
shoulder blade there were present two
adjacent oval plaques which seemed to
be made up of waxy, shining nodules
of a bright red color, slightly depressed
in the center. Besides the adminis-
tration of arsenic, a 10 per cent, alco-
holic-epicarin solution was ordered to
be applied to the affected skin. Ac-
cording to the patient's statement the
itching subsided even after the first
application. The disease itself only
partially disappeared, three months
having elapsed since the beginning of
the arsenical treatment.
Case III, Urticaria. — W. S., twen-
ty-one years old, was attacked after
eating raw oysters for the first time,
with an extensive urticarial eruption.
The existing pruritus was promptly re-
lieved by the application of a 10 per
cent, alcoholic solution of epicarin.
Case IV, JUingworm. — P. O. M.,
eight years old, has suffered since a
week with a cutaneous eruption on the
backs^ofboth hands as well as the left
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24
Original Articles.
cheek. The ring-shaped lesions were
very characteristic, while the scraped
off scales, after staining according to
the method of Waelsch, showed the
distinct presence of the trichophyton
tonsurans. The treatment consisted
of a 10 per cent, alcoholic solution of
epicarin, applied morning and night to
the affected parts with a brush. A
cure resulted in five days without re-
action.
A sister of this patient who came
under observation in the early stages
of the disease presented slightly raised
red patches without any central heal-
ing. In this case two applications of
the solution were sufficient to produce
a cure.
Case V, Eczema IneMrtgo. — T. P.,
twenty-eight years old, pharmacist,
had suffered since a number of years
from an obstinate intertrigo. His last
attack appeared in July of this year
and was particularly characterized by
violent itching. The application of a
15 per cent, alcoholic solution of epi-
carin, however, rapidly removed this
distressing symptom.
This comprises my personal experi-
ence with epicarin, and I have no doubt
that further observations will show this
new drug to be an antipruritic par ex-
cellence.
LiTKRATURB.
1. M. Kaposi: Epicarin, a New Remedy (Wiener Med.
Woclienschrift, No. 6. 1900).
2. G. Pfeiffenberger: On the Use of Epicarin in Der-
matology (Klin. Tlierap. Wochenschrift, No. 19, 1900).
Idem: Farther Observations on Epicarin (Klin. Therap.
Wochenschrift. No. 29, 1901) .
3. E. Kraus: On the Use of Epicarin in Certain Cuta-
neous Affections in Children (Wiener Med. Zeitung, No.
24, 1900).
4. I. H. Bille: On the Application of Epicarin in Cuta-
neous Diseases (Die Heilkunde, September, 1900) .
5. F. Siebert: Experiments witn Epicarin in Scabies
(Munchner Med. Wochenschrift, No. 43, 1900).
6. F. Winkler: A Contribution to the Therapeutics of
Epicarin (Monatsh. f. Pract. Dermat., Bd. 33, No. 8).
In sycosis, Fox recommends the use
of the following ointment after epilat-
R
Zinc oxide
Zinc carbonate .
Rose ointment ....
....aa 3 j
....ad S j
KOILONYCHU AND ITS SUCCESSFUL
TREATMENT; WITH THE REPORT
OF SOME CASES.*
Bt A. H. Ohmann-Dumssnil, St. Loais.
The diseases of the nails are of more
than ordinary interest to him who can
interpret them properly. Each one con -
stitutes a symptom or a complex of
symptoms which point to a condition
at times limited to the onychial tissues,
and at others indicative of a general
condition of the organism of a more or
less pathologic nature. Every one
is acquainted with the appearance
of the clawed nails in tuberculo-
sis of the lungs, more especially
when associated with the charac-
teristic clubbed fingers. The distal
phalanx is thickened, ** clubbed," and
bears a nail with a certain amount of
curvature, and bluish, as well as ac-
companied by a generally unhealthy
appearance. Every constitutional dis-
ease is associated with a characteristic
appearance of or change in the nails,
each one of which is an index of suffi-
cient importance to lead to more thor-
ough examination if it is to be cor-
rectly interpreted by the examiner.
Whilst all this will be readily acknowl-
edged by any one who has devoted
some attention to the subject, it will
also be conceded that the literature of
diseases of the nails is apparently
sparse, and that not much has been
written upon them. In reality quite
an amount has found its way in peri-
odical literature, but scattered to such
a degree and in different languages
which have acted as a greater or less
deterrent to him who desires to acquire
a knowledge of the subject. With
such difficulties to overcome it is easily
understood that the general practi-
tioner is unable to acquire even a
superficial knowledge of that which
should certainly be to him a most im-
portant part of his post-graduate med-
ical education, were he but sufficiently
enlightened in regard to it. His re-
course to text-books on skin diseases
* Rea 1 before the Missouri State Medical Association.
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Koilonychia—Ohmann-Dumesnil,
26
only leads to failure and disappoint-
ment, as these appendages of the skin
receive but scant courtesy.
The greater portion of the ex-
ceedingly short notices written on
diseases of the nails are almost en-
tirely confined to onychogryphosis
and onychomyocosis described in such
a summary and perfunctory manner
that but little of real worth can be ex-
tracted from them. The atrophic
troubles of the nails are either omitted,
so far as a consideration of them is
concerned, or they are entirely omitted.
In fact, the whole subject is so en-
shrouded in darkness that the nails
would seem to have been relegated to
the limbo of those subjects which
constitute an opprobrmm medicince.
Whether this is due to a certain idea that
they are not deserving of more atten-
tion, or to a lack of study concerning
their defects and troubles, or a self-
acknowledged weakness to properly
combat the diseases of nails, the writer
will not undertake to determine. The
fact remains, however, that there is
not sufficient attention paid to these
diseases in text-books and, as a natural
consequence, a rather deplorable lack
of knowledge respecting them. That
this should exist can be easily under-
stood when some authors have but one
term for diseases of the nails, which
really means nothing. It is a general
one, whose meaning lacks in specificity^
and means nothing to him who may
even be conversant with the diseases
of the nails. What is referred to is
the name onychia. This simply im-
plies an affection of the nail or nails
and means nothing beyond what any
layman might say and does say when
he applies for treatment. The meaning
of the term is a very general one, and
on account of this lack of specificity it
is practically worthless. We will not
further discuss this phase of the sub-
. ject, but rather enter into a considera-
tion of that concerning wfiich we de-
sire to say a few words and give some
definite ideas concerning the recogni-
tion and successful treatment of a con-
dition which is by no means rare, but
which, up to this time, has not received
the recognition which it deserves.
The disease concerning which I de-
sire making a few remarks is an inter-
esting one in several respects. It is
known technically as koilonychia and
ordinarily as "spoon" nails. It is by
no means a rare condition, but one
which, unfortunately, has attracted
but little attention from those who
practice general medicine, from the fact
that very little importance has been
attached to it, and patients afflicted
with the trouble have paid but very
little attention to it. Outside of any
medical interest attaching to it, it is of
a sufficiently marked character in
many cases to attract attention to it,
and jt becomes, after a certain time, an
object of more or less solicitude to the
patient.
Koilonychia may be observed in one
or more of the nails of the fingers of one
or of both hands, although the latter
is not so frequently observed as iti^
presence in a few fingers. The appear-
ance presented by the nails w^hich are
involved differ in different stages of
the disease. It may be stated in gen-
eral terms that the beginning is char-
acterized by a flattening and thinning
of the nails. This is very slow but
progressive, and this very slowness
makes it unperceived by the subject of
the trouble until it is well marked, and
it suddenly dawns upon his mind that
the nails are not normal. In addition
to this there is a curving of the nail
from side to side, which gives the
characteristic shape that has given the
name of "spoon" nail. This condition
has been so marked, in certain cases^
as to give rise to alarm, although it
merely pointed to a deeper condition
which was really of a serious nature.
The thinning of the nails acts as a
drawback in the performance of certain
work, and not alone this, but there is
also considerable pain experienced in
the performance of many ordinary acts>
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Original Articles.
such as writing, sawing, and other
work requiring a certain amount of
pressure to be exerted upon the pulps
or sides of the distal phalanx. The
nails themselves are not normal in
color, and are very apt to be fissured
longitudinally through any slight
trauma. Another accident to which
they are liable is that of breaking trans-
versely and more generally at the line
of juncture of the nail and nail-bed, or
at that point where the nail becomes
free. These are some of the symp-
toms which patients will abserve and
to which they will call particular at-
tention. One point which requires
particular attention is the dryness of
the nail, which is so great in many as
to amount to positive brittleness;
whereas, in others the nails are elastic
and susceptible of being doubled up
without producing even a crack in the
surface.
A peculiarity in this disease, and it
is one which occurs quite often com-
paratively, is the involvement of only
the distal half of the nail, the proxi-
mal or attached half presenting a nor-
mal appearance. In these cases we
have the added peculiarity of the ex-
treme thinness of the free extremity
of the nail and its Assuring, with the
presence of V-shaped areas of small
portions of the nail, the small fissure
extending upwards from the apex of
the V. Unna has reported a case of
complete leukonychia, in which some
of the nails present the appearance of
koilonychia. Heller, in his monograph
on the '* Diseases of the Nails," pre-
sents the picture of one of his cases,
as well as that of one of Rille, in which
the characteristic appearance of the
disease is well represented. In fact,
it may be stated that koilonychia is a
disease which, from the paucity of the
literature devoted to it, can hardly be
regarded as being so rare. lie who
will but observe the nails on all the
hands which he has occasion to exam-
ine will find that it is a comparatively
common condition. With these few
preliminary remarks I will now proceed
to give the histories of a few cases
which are typical, after which I shall
proceed to a consideration of the eti-
ology, pathology and treatment of the
trouble. But a very few cases have
been chosen out of a large number ob-
served by me in the past few years.
Case I. — Miss X., eighteen years
old, applied for treatment for a condi-
tion which she considered most pe-
culiar and which she was fearful was
an indication of a very serious general
condition. An examination demon-
strated the fact that the nails of both
hands were affected and presented a
classic picture of **spoon" nails. They
were unusually thin, so much so that a
slight pressure upon any one caused a
sinking of the nail, which persisted for
about fifteen seconds and evoked a
rather sharp pain. In addition to the
concave condition there existed other
evidenced of an atrophic process. The
nails of the little fingers, of the right
ring-finger, of the index fingers and of
the thumbs showed small circular pits
or depressions a little larger than a
pin-point, and shallow, narrow, longi-
tudinal furrows which could be de-
termined more exactly by the touch
than by ordinary inspection without a
glass.
The patient stated that the thinning of
the nails had begun about three years
f>reviously , when she began to menstru-
ate. The establishment of this function
had acted upon the nervous system, and
probably with more effect, from the
fact that she was of that nervo-lym-
phatic temperament so often observed
in blondes, of which she was one.
Her nervous condition had been much
aggravated by worry over her nails
and the fact that all her attempts to
be treated had been discouraged
by those medical men to whom she
had applied and who merely gave
her the consolation that the matter
amounted to nothing. Careful ques-
tioning brought out the fact that she
wa^ suffering from nerve starvation,
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KoilonychA—Ohmann-Dumesnil.
27
and, in fact, was rapidly approaching
that deplorable state known as neuras-
thenia, led me to prescribe internally
sl phosphorus pill of one-fiftieth of a
grain, gradually increased to one-
twenty-tifth, to be taken three times
daily during meals. Locally she was
ordered to rub into each nail thor-
oughly and carefully, twice daily, the
following ointment:
R Stansi oleat „ 5j.
Lsnolioi poriss,
Uug. aqu8B rosae ^ „.a«Ss8.
M.
Sig. Bub into nails twi«e daily.
At the end of five weeks I had the
satisfaction of seeing the case practi-
cally cured. I had the patient call later
when the nails had been completely
renewed in growth, and they were nor-
mal in every respect. They were once
more well formed, showed no atrophic
-changes, were of normal thickness and
were once more what she called
strong.
Case II. — Mrs Y., aged thirty -two,
with one child, was sent to me with an
aggravated case of syphilis, which she
acquired from her husband after the
birtJi of her child. When I saw her
she was divorced and forced to earn a
living as a seamstress. Her syphilis
had had a very depressing effect upon
her for two reasons. In the first place,
she desired to keep her malady a
secret, no one outside of her family
physician being aware of the true nat-
ure of the case. In addition to this,
her being sent away from home for
treatment on account of the severity
of her case worried her. Her syphilis
presented the lesions of a disseminated
squamous syphilide attacking the en-
tire body with the exception of the
face. Both the dorsal and palmar
surfaces of the hands were affected in a
marked manner, and this eruption had
proven quite refractory to the treat-
n^nt administered. The nails of some
of the fingers presented the typical
appearance of koilonychia. The nail
of the right index, the ring and little
fingers offered the same changes. On
the left hand, the nail of the thumb,
of the middle and of the ring finger
also presented this appearance. Atro-
phic circular depressions could be
found in all of them, but no furrows
that were at all marked. No particu-
lar medication was ordered for the
nails beyond rubbing them with the
same ointment used on the eruption.
Internally, a rather radical mercurial
treatment was given. As the syphilis
improved the koilonychia did, and this
latter has disappeared, although the
luetic condition is far from being com-
pletely healed. The entire result has
been a most satisfactory one, the pa-
tient being particularly gratified at once
more having normal naUs which are
strong and free from all pain on pres-
sure. The color, which was cyanotic^
is now pink, and the improvement is
plainly discernible. In fact, the nails
are as nearly normal as they could be
found in a syphilitic who is progres-
sively improving.
Case Hi. — Z., a young man of
twenty-six, applied to me on account
of his nails, which troubled him chiefly
on account of their appearance. They
presented the typical appearance of
the disease, although not in a very
marked degree. It was sufficiently so,
however, to have aroused his solici-
tude, and made him apprehensive that
it possibly presaged some very serious
condition. He stated that he was in
charge of a rather important depart-
ment of a railroad, and had much work
of a mental nature to do and many
cares upon his mind. It could be eas-
ily seen that he was troubled in mind
and restless in spirit. He did not rest
easily on account of his many duties,
and the added trouble which he had
on account of his local condition did
anything but conduce to his physical
or mental well-being. He was in such
a state that he was rapidly bordering
on a general breakdown. All of his
nails were affected, more especially
the distal half of each one, and his
Digitized by
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28
Original
constant care in keeping bis nails pared
down had led to the small fissures so
often observed in cases of this sort.
His endeavor to prevent a further ex-
tension of the fissures by paring had
led to the production of a number of
triangular notches, producing a saw-
like condition of the nails. These were
thin, and their beds appeared anemic,
as evidenced by their pale bluish color.
The treatment in this case consisted in
both management and medicines.
Strict injunctions were given not to
pare or in any other way disturb the
nails mechanically. In the next place,
hygienic rules were given and such ex-
ercise advised as would tend to increase
vigor and muscular tone. Locally was
ordered the ointment to be applied to
the nails as given in the history of
Case I. Internally, the patient was
ordered to begin with a one-fiftieth
grain phosphorus pill during meals,
this being gradually increased to one-
twenty-fifth grain. In addition to this
the following Asiatic pill was ordered
to be taken after each meal :
R Acidi arseniosi gr. iij. ™
Pulv. piperis nigris 3"J-
Ext. gentian q s.
M. ft. caps. (No. 5) No. 60. , _^
Sig. One capsule after each meal.
Under this treatment the patient im-
proved steadily in all respects, but the
most marked change for the better
took place in his nails. During all this
period it was not necessary for the pa-
tient to quit his occupation or modify
it in the least degree, his improvement
progressing with the treatment.
Case IV. — W., a young unmarried
man of twenty-eight, came to me for
the treatment of erythematous skin
disease of the face. He stated that he
was an accountant, and was also en-
gaged in the occupation of soliciting
sales for the firm of which he was a
partner. As he detailed his history,
his nails attracted my attention and a
closer examination showed them to be
rather larger than normal so far as
their width was concerned. In addi-
Articles.
tion to this, they were quite thin and
inclined to be concave. The case was
one of koilonychia, although not a very
marked one. The nails did not show
any tendency to fissure, and yet their
thinness was quite marked. An oral
examination showed that the young
man was worried and his strength
overtaxed, he himself remarking that
his nervous system was run down.
Although he presented what would be
regarded as a good physical condition,
his nervous organization was evidently
below par. He was fidgety, restless,
. and presented the evidence of one who
was dissatisfied with matters. Whilst
he had never done any manual labor to
amount to anything, he bitterly com-
plained of the appearance of his nails.
He deplored the fact that his nails no
longer presented the normal appear-
ance which they formerly did, and he
acknowledged that he felt very sensi-
tive on the matter of the change in his
nails. As his cutaneous trouble de-
pended upon the same cause as the
original affection, a simple soothing
lotion was ordered for his face and the
same treatment as in Case III., for his
nails. Progressive improvement took
place, and his nails, whilst not yet re-
stored to the normal, bid fair to be so
at no very distant future.
Many more cases could be cited, but
those given are sufficient to give an
idea of the trouble, the conditions
present, and of the treatment which
has proven successful. The examples
which have been mentioned are not
selected cases, but rather a few taken
at random, to illustrate some different
forms of the disease. It may have
been noticed that in these cases no
mention has been made of the toe-
nails. This has been done advisedly
as in none has there been any involve-
ment of the latter. As a matter of
fact, I have found that there is no im-
plication of these, and but a very few
are mentioned by those authors who
have contributed anything on the sub-
ject. So that until more are seen in
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Koilonychia—Ohmann-Dumesnil.
29
this location, it would appear rather
premature to make any extended re-
marks upon this particular phase of
the subject.
An interesting question connected
with the disease under consideration
is its etiology. All those who have
written on koilonychia, dismiss the en-
tire matter in a very few words and
have very little or nothing to say on
its etiology. It will, perhaps, be bet-
ter to sum up their views, and then
draw those conclusions which seem to
be legitimate in view of the appear-
ance, treatment, and other facts con-
nected with cases which have been ob-
served, including the changes which
have been noted. As has already been
stated, the available literature on the
subject is sparse, and in no instance,
has any extended consideration of the
subject been made by any author.
H.Radcliffe Crocker says*: '*Spoon
nails, in which the nail is thinned and
€oncave from side to side with the
edges everted, and with hollowing to a
less degree, sometimes antero-posteri-
orly, have been observed id some
wasting diseases, but also there are a
few cases on record where the etiology
is obscure." This will certainly ap-
pear very short and unsatisfactory to
any one desirous of beinff informed on
the etiology of this disease, and it cer-
tainly shows a certain amount of want
of interest in the matter.
We are treated to more on the sub-
ject by Dr. Julius Heller ;t who states
that in a case observed by him in a
servant girl of twenty-five, nothing was
observable beyond the fact that she
was chlorotic. He quotes Professor
Rille, of Innsbrueck, who reported a
<5ase to him in a peasant's daughter of
thirty-five, who was anemic and in
whom the disease had existed since
childhood. At a meeting of the Berlin
Dermatological Society, Max Joseph
presented a case of koilonychia com-
plicated by total leuconychia. He re-
* Digeages of the Skin. Philadelphia, 1893, paee 834.
t Die Krankheiten der NaBgel. Berlin, 1900, page 134.
garded the leuconychia as being due to
the general anemia of the patient, al-
though others who were present, con-
tended that it could only be explained
through the action of the subungual
hyperkeratosis which was present.
Heller states that in Joseph's case it
existed only in the most slight degree
and was completely absent in his case.
Professor A. Jarisch,* after quoting
Heller and a few other authors in which
he rejects Unna's theory, because it
might appear plausible were the same
conditions always observed and in every
case, concludes that a definite and con-
clusive explanation cannot be given
until microscopic examinations of a
satisfactory nature are made, in which
opinion a number of authors share.
Joseph Zeislert in speaking of fur-
rows in nails and their causation by
systemic diseases says: "More rarely
observed, yet somewhat related to the
foregoing, is an anomaly consisting in
a sort of excavation or central depres-
sion of the nail plate, due in all proba-
bility to a process of shrinking in the
nail bed. This condition has been de-
scribed by Crocker as spoon nails, and
elsewhere as koilonychia."
From the opinions which have been
quoted above there can remain no doubt
that the subject of the etiology of
koilonychia is involved in a great deal
of obscurity. Any one who will exam-
ine into the histories of the cases ob-
served and of those detailed by writers
cannot fail to notice that one underly-
ing fact is apparent in all, and this
points to the inevitable conclusion that
the disease before us is a trophoneuro-
sis manifested by an atrophy of the
nail plate as well as of the nail bed.
The coincident presence of leuconychia
is merely confirmatory of the cause,
and the general state of the organism
in the patients is of such a form as
would encourage neuratrophic changes
in the different anatomical parts of the
skin as well as in its appendages. We
* Die Hautkrankheiten. Vienna, 1901, page 1032.
t Trophic Affections of the Nails.. Jour. Cut. and Genito
Urln. Diseases. 1901, page 511.
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80
Original Articles.
are here brought face to face with a
condition which has factors which
make the entire matter a most pozzling
one and correspondingly difficult of
solution. Whilst we may understand
thai all the nails of the hands are not
affected it is rather difficult to explain
the fact that the toe-nails are exempt
from the process. These questions are
still sub judice ; but there can be no
doubt that confirmatory proof of the
fact that koilonychia is a trophoneuro-
sis is furnished by the success which
attends a treatment directed to an
amelioration of the nutrition and gen-
eral toning up of the nerves, more
especially the sympathetic system,
which is generally understood as being
instrumental in bringing about trophic
changes. The whole subject is a most
interesting one, and worthy of serious
study at the hands of sound investi-
gators, If an interest is awakened in
the nail disease we have no doubt that
there will be many who will devote
time to its further elucidation.
Equally as unknown and of as much
interest is the pathology of this trouble.
Whilst post-mortem examinations will
show some changes, any thorough
pathologic examination will have to
depend upon the examination of biopsic
specimens. There is no doubt that
there exists a shrinkage ( schrumpf ung)
of the nail bed, and this, by diminish-
ing the nutrition of the nail, brings
about a consequent atrophy. The nail
itself becomes thin and its attachment
to its bed weaker and weaker, leading
gradually to a curving of the sides which
are not so tightly attached. Hence
the development of the concavity which
is observed This question of pathol-
ogy is one which requires a great deal
of research, and it is only a lack of ma-
terial which has prevented examination
of a satisfactory nature. No one will
consent to sacrifice a distal phalanx for
this purpose, and in no other way can
satisfaction be obtained.
What is perhaps of more interest to
the practitioner is the successful treat-
ment of the condition. It may be wel
to premise that the nails are very slow
to respond to any therapeutic meas*
ures, as they are endowed with no sen-
sation and derive all their nourishment
from the nail bed, there being no circu-
lation in the nail itself. It is by a
slow process of absorption that nutri-
tion is established, this determining the
reason for such marked changes fol-
lowing a slight disturbance of circula-
tion such as will follow a failure in the
trophic nerves in affording the normal
stimulation necessary to establish a
proper circulation. It will also serve
to explain the fact that quite some
amount of time is necessary to obtain
any result ; and the reason why females
are benefited more than males is that
the former are more patient as well as
persistent in carrying out a treatment.
In order to obtain permanent good re-
sults a long period of time is often
necessary, but such result can be at-
tained. It should always be impressed
upon patients that this is a conditio
sine qua non^ and those who are not
ready to stand a long siege might as
well not undertake the cure of koilo-
nychia. We have seen patients who
refused a long course of treatment
come back for dehiscence of the nails
and cheerfully submit for any length
of time. It is well to tell of the possi-
bility of this and warn them of it. In
those cases in which the cause is Ray-
naud's disease too much must not be
promised. It is pretty well established
that the cause of symmetrical asphyxia
of the extremities is trophoneurotic in
nature, and unless the course of the
process can be arrested little hope can
be offered for a complete cure of either
one or the other of the diseases. So
that much depends upon the proper
selection of a case. That is to say, a
patient who will not be willing to carry
out the treatment for a long time had
better not be encouraged to begin with
it, as he will be doomed to disappoint-
ment and his physician to failure.
This is not the only point to observe.
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KOILONYCHIA-OHMANN'DUMESNIL.
31
Much care should be exercised in the
proper choice of remedies, as well as
the methods to be used in their appli-
cation. As in all questions of thera-
peutics, DO haphazard or guesswork
can be indulged in or continual changes
Qiade. For the purpose of local med-
ication, I have found the diluted oleate
of tin to be the best. It is a true nail
tonic, and it is a consistent one. Some
German writers have used the oxide of
tin, but they have not repoi-ted particu-
larly brilliant results from its use. In
fact, the oleate of tin must be very
properly made or it will fail of its pur-
port and I desire to say that the make
of Parke, Davis & Co., of Detroit, is
that which has best served my purpose
in all cases. The method of applica-
tion should be with a nail polisher, as
this will insure its penetration into the
nail substance. But little of the oint-
ment need be placed upon the nail be-
foi*e it is rubbed in, but it must be very
thoroughly applied. So far as the
general treatment to be followed in
koilonychia, as much or even more
care must be exercised in the choice of
the remedies used. The remote cause
of the trophoneurosis must be de-
termined and the treatment directed to
that. Thus, in Case II, reported in
this paper, the cause was syphilis and
the treatment was directed exclusively
to that, although it would have com-
pletely failed in a non- luetic patient.
Of course, it is necessary that the phy-
sician possess a good knowledge of
general medicine and of the remedies
particularly adapted to the neurotic
conditions observed in the patient un-
der treatment. This it is which per-
haps makes the treatment of nail dis-
eases so difficult and demands so much
more at the hands of the medical prac-
titioner. Too many of the latter class
look upon affections of this nature as
of very secondary importance, when
really the whole fault lies in their un-
willingness to acknowledge their ina-
bility to successfully treat a case. The
very paucity of monographs and arti-
cles on diseases of the nails is
evidence of the fact that little attention
is paid to them, and a corresponding
lack of knowledge in regard to them
exists. Koilonychia in particular is
worthy of extended study at the hands
of medical men, as it is a trouble which
is rich in its indications of general
neurotic trouble in some cases. So
little has been written upon it and so
few cases have been thoroughly exam-
ined that a most fertile field is opened
to those who will devote time to its
further study. The pathology of the
disease is still unworked, and a thor-
ough study of this particular portion
is certainly destined to yield rich and
useful results.
It must not be forgotten that this
particular deformity of the nails, like
all others, forms a most useful indica-
tion to various systemic troubles, and
is worthy of ijiore consideration than
has been heretofore accorded to it.
Those books which speak of it, incom-
plete as the subject-matter devoted to
it may be, are deserving of serious
study on account of the suggestions
which are made and which would lead
to a further developmant of the mat-
ter. A closer study of the disease will
inevitably lead to suggestions of treat-
ment for many cases which are looked
upon as incurable, and some real prog-
ress, as well as useful information on
a large class of obscure diseases, will
be made. One need not specialize his
practice to do this, and a thorough con-
sideration of the various points in-
volved will, beyond all doubt, benefit
the medical profession by affording to
it something real and useful, as well as
tangible.
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Original Articles,
URTICARIA, ITS VAQARIBS AND
TREATMENT.
By S. C. Mabtin, M. D., St. Louis.
This cutaneous eruption in its dif-
ferent forms is so often an accompani-
ment of other diseases and morbid
conditions of the system, that it would
be more properly designated as a
symptom than as a separate disease.
We find it generally described as a
non-contagious inflammation of the
skin attended by the development of
ephemeral round or oval wheals, either
red or whitish in the center with a
surrounding red areola. These eleva-
tions range in size from a small papule
to nodules of an inch or more in diam-
eter, and even sometimes running into
edematous infiltrations of considerable
extent. The prominent subjective
symptoms are itching, burning and
tingling sensations. This eruption is
sometimes attended by a high febrile
movement and serious constitutional
disturbances; at other times the gen-
eral organism seems to be in a fairly
normal condition. During the course
of many contagious and visceral dis-
eases, urticaria is an incidental feature
which often embarrasses the diagnos-
tician.
The antitoxins, new drugs and nu-
merous pharmaceutical preparations
which are being constantly prescribed
by physicians, make these uticarial
eruptions much more common than
they formerly were. The extravagant
habits and luxurious indulgences of
modern life, with their resulting dys-
peptic and neurotic disorders, have
also contributed much to the increas-
ing prevalence of urticarial eruptions.
Imperfect transformation of tissues and
retention in the system of toxic mate-
rial which should be excreted, add
their influence to the Ipnglist of causes
w^hich provoke these cutaneous disor-
ders. But all these things alone would
not be sufficient to produce urticarial
eruptions without the existence of a
predisposition to the occurrence of se-
rious exudation of the cutaneous tis-
sues, from the fact innumerable in-
ternal and external causes which are
constantly operating upon a large class
of people do not in very many cases
provoke urticaria. A peculiar condi-
tion of the skin has been revealed in
certain susceptible persons by what is
called dermographism. With a pencil
names or figures may be written on
their backs ; these names or figures are
simply linear infiltrations produced by
the movement of the pencil on the
person's skin. Urticaria is undoubt-
edly the expression of a vaso-motor
disturbance of the skin tissues in per-
sons of irritable neurotic proclivities.
The poison of small-pox will some-
times produce a prodromal rash in the
form of an urticaria a day or two be-
fore the development of the- typical
small-pox eruption. This happens only
in that class who have urticarial sus-
ceptibilities. The toxic products of
undigested food absorbed and thrown
into the circulation, act as irritating
substances ^nd provoke urticaria in
those predisposed to such lesions of
• the skin. The mucous membranes, or
the internal skin, may also develop
these lesions ; and possibly in the seri-
ous febrile cases, where there are
gastric and intestinal complications,
these internal lesions are responsible.
When the urine shows a marked de-
crease in urea and uric acid, often the
most stubborn cases of urticaria result.
I have known these cases to be
promptly relieved by the adminifi*tra-
tion of colchicum or salicylate of soda
when all other remedies had failed. In
all chronic and apparently incurable
cases the urine should be tested, when
it will often be found that there is a
deficiency of organic salts, with their
probable retention in the system.
In some persons with peculiar idio-
syncrasies, urticaria results from in-
gestion of certain kinds of food. Cer-
tain kinds of fish, meat, vegetables and
fruit will provoke an attack. In many
of these cases it is very likely these
articles of food have undergone some
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Pathogenesis and Treatment of Diabetes Mellitus. ss
putrefactive changes before they were
-eaten, evolving toxic products which
■excited the trouble. Most people know
little and care less about the quality of
their food as long as it is palatable.
The same is true of the beverages they
iise, and for this very reason the phy-
sician should give such matters his
especial attention. The success in
treatment of all skin diseases is
achieved more signally along dietary
than medicinal lines. This is often
-demonstrated in patients who, after
having been, for months drugged with-
out any benefit by one physician, are
cured by another who prescribes hy-
giene and diet instead of drugs.
In most cases of urticaria, saline
■aperients, diuretics and intestinal anti-
septics with rational hygienic and die-
tary management will soon effect a
-cure. When these means fail, a
searching effort must be made to ascer-
tain and remove the cause. Let atten-
tion be directed to the correction of
those inherited or acquired nervous
susceptibilities which operate as pre-
•disposing causes. Build up crippled
organs and restore functional activi-
ties. Cleanse the stomach and intesti-
nal canal, and keep them free from
ptomaines and other toxins. See that
the stomach and intestines furnish the
proper secretions for the purposes of
digestion, and that the liver and pan-
■creas supply the proper digestive fer-
ments to prepare the food for absorp-
tion and utilization. See that the kid-
neys, liver, lungs,. skin arud bowels re-
move from the system all waste mate-
rial and noxious matter. Attention to
nil these details in some cases is abso-
lutely necessary to insure successful
' results.
During convalescence, if the vital
powers have been reduced, tonics with
•alkalies or acids, according to the re-
•quirements of the case, may be pre-
scribed. In some cases of an intermit-
tent form, quinine should be given,
and when rheumatism is associated
with urticaria, a combination of iodide
of potassium, bromide of potassium
and chloral hydrate, each in ten-grain
doses, may be prescribed three or four
times a day. Atropine in doses of one
one-hundred and twentieth of a grain
three times a day will sometimes be
serviceable. Salicylate of soda in fif-
teen grain doses in obstinate cases,
three times a day, will often give prompt
relief, but smaller doses will rarely be of
any service. Iron, arsenic and strych-
nine, in connection with saline aperi-
ents, in some chronic cases have a ben-
eficial effect. Warm and cold baths
^ alternated, may at times be used to
good effect. The excessive itching will
often yield best to the following lotion :
Bichloride of mercury grs. x, spirits of
rosemary and alcohol each Si, emul-
sion of bitter almond gvi. M. Sig. —
Sponge the parts two or three times
a day.
<fi^o
PATHOQENBSIS AND TREATMENT OF
DIABETES MELLITUS.
The clinical phenomena of this dis-
ease have been elaborately studied for
a century or more by the best
equipped minds of the medical profes-
sion without shedding much additional
light on its etiology, pathology or
treatment. The laboratory has also
been appealed to, with equally barren
results. While definite knowledge has
not increased its boundary to any con-
siderable extent, theoretical teachings
in multiplicity and variety have as-
sumed such proportions as to bewilder
and confuse the medical mind.
The most prominent clinical revela-
tion of this pathological condition is
pronounced glycosuria. This is not
the disease, but is simply a finding
which furnishes the starting point for
investigation of the disease. The pres-
ence * of sugar in the urine does not
cause the trouble, but its diversion
from the channels of nutrition is a
matter of deep concern. It is natural,
in the absence of any known organic
disease which we can assign as a cause
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34
Original Articles
of augar in the urine, that our atten-
tion should be directed to suapeoted
organic lesions, neuroses or disordered
functions of the digestive apparatus.
We have either excessive sugar pro-
duction in the organism or diminished
sugar destruction, and in some cases
probably both. In the milder types of
the disease the sugar is undoubtedly
derived from the carbohydrates of the
food, for by withdrawing this kind of
food, sugar in the urine disappears.
In the severer forms of the disease
sugar continues in the urine after the
withdrawal of the carbohydrates. In
these oases it must be produced from
the proteids of the body.
In our efforts to ascertain why sugar
is formed in excess or why, when thus
formed, it is not oxidized, certain facts
repeatedly confirmed by scientific in-
vestigation should be carefully con-
sidered. For example,a variety of nerve
lesions may induce glycosuria. Irrita-
tion or puncture of a circumscribed
area in the floor oi the fourth ventricle
in the medulla is followed by the ap-
pearance of sugar in the urine., If the
vagus nerve is divided in the neck, or
if the spinal cord be divided above the
origin of the great sympathetic nerve,
diabetes may result. This shows that
nerves exert a powerful influence on
the functions of organs.
Nutritional changes are also depend-
ent upon digestive ferments, especially
those of the liver and pancreas. Any
organic or functional disorder of these
glands will alter or diminish their
secretions and to that extent impair
the processes of nutrition. There is
probably something supplied by the
normal pancreas besides amylopsin
which promotes certain changes in the
carbohydrates and prepares them for
the uses of nutrition. When sugar is
properly prepared for absorption and
appropriation by the blood it passes to
the liver for further changes, under-
goes combustion in the lungs, gen-
erates heat, and thus aids in saving de-
struction of the albuminoid constitu-
ents of the body. In certain d^bili*
tated conditions of the system tJbie^
inhalation of oxygen is restricted^-
oxidation of si^r is lessened, and
much of it passes through the kidaeyja-
to the bladder, producing jglycosuria..
Dr. George Alexander uibaon re-
ports twenty-four cases of diabetes-
mellitus in which sixteen showed
changes of the pancreas^ possibly in
some of the other eight cases there
may have been functional disturbancea
of this gland which escaped attention..*
Many observers during the past cent-
ury have recognized a close relation
between diseases of the pancreas and
diabetes mellitus. A. W. Mayo Rob-
son and B. G. A. Moynihan in their
work on ''Diseases of the Pancreas,"
in speaking of the relations of the-
pancreas to diabetes, state: 1. Extir-
pation of the whole pancreas produces
diabetes. Extirpation of nearly the
whole pancreas gradually induces dia-
betes. Extirpation of a limited part
of the pancreas does not produce dia-
betes. 2. Diabetes in a large number
of cases is associated with or accom-
panied by diseases of the pancreas^
the most f reqent of which is a chronie
interstitial inflammation and sclerosis..
There are, however, eases of diabetes
in which tjiere is no demonstrable af-
fection of the pancreas and cases of
chronic interstitial inflammation with-
out diabetes. The authors however do-
not deny that in the cases of diabetes-
disconnected with discovered pan-
creatic disease there may have b^n
some obscure undiscovered organic or
f unctional disease of the gland.
Hansemann quotes from the post>-
mortem records of the Berlin hospitals
in the period of ten years, forty oases
of diabetes with disease of the pan-
creas, eight cases of diabetes without
disease of the pancreas, six cases of
diabetes without any note of the con-
dition of the pancreas, and nineteen
cases of disease of the pancreas with-
out diabetes. The forty cases men-
tioned include thirty-six oases of
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Pathogenesis and Treatment of Diabetes Mellitus 85
simple atrophy, three of sclerosis and
atrophy, and one of complex change.
R. T. Williamson famishes a table
which shows the condition of the pan-
creas in twenty-three consecutive cases
of diabetes, viz.: 1. (Extensive
changes) two cases of marked cirrho-
sis, one case of cancer. 2. (Fairly
well-marked changes) two cases of
cirrhosis, one case of lipomatosis, one
case of atrophy, fatty degeneration
and inflammation, one case of very ad-
vanced atrophy. 3. (Slight changes)
one case of atrophy with slight fatty
degeneration, two of atrophy without
other changes. 4. Four cases of
atrophy, but only in proportion to
other wasting. 5. Eight cases of pan-
creas normal macroscopically and mi-
croscopically. In twelve of the above
eases the pancreas was either normal
or only atrophied in proportion to the
general wasting.
According to available statistics at
least one-half of all cases of diabetes
are associated with recognized disease
of the pancreas, but how many are
accompanied by functional derange-
ments of this gland, we have no means
of knowing. Certain groups of cells
lying in the interalveolartissue of the
pancreas are made up of small, irregu-
larly polygonal cells with a round nu-
cleus and homogeneous refractive cell
body. These structures are known
as the ''islands of Langerhaus," and
are supposed to be the main source of
the glandular secretion. It is now
supposed that in partial extirpation of
the pancreas from which glycosuria
did not result, these islands were not
destroyed, and where glycosuria did
result, they were destroyed.
In forming an opinion of the etiol-
ogy and pathogenesis of this disease,
we must recognize certain facts:
1. That nutritional changes character-
ize all cases of diabetes. 2. That the
nervous system is deeply implicated in
a large number of cases. 3. That dis-
ease of the pancreas is more constantly
associated with diabetes than that of
all other organs combined. This con-
stancy of association must possess
^ome etiological significance, especially
in the almost invariable absence of
other organic lesions. We realize the
importance of the pancreatic ferments
in intestinal digestion. They take the
lead in preparing the carbohydrates,
the hydrocarbons and proteids for util-
ization in nutrition. When the nutri-
tive processes are disordered it is nat-
ural that we look in this direction for
the cause of such disturbances. There
is very just ground for the presump-
tion that in the pancreas and the cen-
tral nervous system, glycosuria often
finds its starting point.
The difficulty, from a therapeutic
standpoint, lies in recognizing patho-
logical conditions of the pancreas. Its
pathology has not been sufficiently
studied. We do not even thoroughly
understand all the functions of thi&
gland. We know it secretes nmy lop-
sin, tripsin and steapsin, and that these
ferments act on the starches, the pro-
teids and the fats, but we do not know
the full scope of their action. We
have every reason to believe that the
pancreas does other work outside of
its action on these three classes of
food, but what that is we can only con-
jecture. When we shall have mastered
these secrets we will probably know
much more about diabetes mellitus.
In the present status of our knowl-
edge the treatment is more hygienic
and dietetic than medicinal, although
the three methods must be intelli-
gently combined. Where the patient
is not too much reduced in strength,
judicious exercise in the open air is
beneficial, for the reason that it pro-
motes the inhalation of oxygen and
thereby increases the combustion of
sugar in the lungs. Great care must
be taken in the withdrawal of the car-
bohydrates from the food. Very often
a too sudden withdrawal of this class
of food, and an oversupply of proteids
without fats, will result in diabetic
coma from poisoning by oxybutyric
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New Publications.
acid. The urine should be tested
•every two or three days, and if it is
found to contain acetone and diacetic
acid, the proteids should be reduced
and the starches moderately increased
in the diet. Whenever a complete
withdrawal of the starches frees the
urine from sugar without increasing
the waste of tissues and loss of
strength, it is safe policy. The pro-
teids should not be used for any con-
siderable period of time without the
accompaniment of the fats. For me-
dicinal agents arsenic, iron and strych-
nine, with the alkaline salts, are among
the most useful aids.
NENA/^ PUBLICATIONS.
A Pbaotical TRKATI6E ON Small-Pox. niustrated by
Colored Photoffraphs From Ldfe. By Geoboe Hrnrf
Fox. A. M., M. £>.. Consulting Dermatologist to the
Health Department of New York City, with the
Collaboration of S. D. Hubbard. M. D., S. Pollitzbb,
M. D., and J. H. Hdddleston, M. D. Parts I and II.
Published by J. B. Lippincott Company, Philadelphia,
The above treatise on small-pox,
with the beautiful and life-like colored
photographs representing the different
stages and types of the disease, will
prove a boon to the medical profession.
With this treatise in the hands of every
physician, a mistake in diagnosis would
seldom occur. Part I takes up the
symptoms, cause of the disease and
<liagnosis, with eight colored plates
illustrating the stages of the disease
up to the ninth day. Part II discusses
treatment and vaccination, and con-
tains seven colored photographs illus-
trating the different stages of the
disease from the ninth- day to the
twentieth, and also one plate represent-^
ing the different phases of vaccination.
Anatomical Researches on the So-Called "Pros-
tatic Hypertrophy" and Allied Processes in
the Bladder and Kidneys. By Stanislaus Cie-
CHANOWSKi. Edited by R. H. Greene, A. M., M. D,
Published by E. R. Pelton, New York City. 1903.
The interesting feature of the above
anatomical researches is the elaborate
pi-esentation of current theories on the
etiology of prostatic hypertrophy, and
the author's careful analysis of the
same, with the conclusions he has
reached clearly stated. The author
asserts that the functional disturbances
of the bladder in old people are gen-
erally due to bladder insufficiency and
not to enlargement of the prostate, as
generally believed. He thinks that
atheromatous changes play an insig-
nificant role in this disease, and that
the prostatic hypertrophy, as a rule,
results from inflammatory processes
which are latent for years, unobserved
by the patient in consequence of the
insignificant symptoms. To what ex-
tent this inflammation is due to gonor-
rhceal processes and their sequences, he
is unable to decide. He says this is a
question for the future to determine.
A Guide to the Practical Examination or Urine. By
James Tyson, M. D. Tenth edition. Revised and
Corrected, with a colored plate and wood engravings.
Price, $1.50, net Published by P. Biakiston's Son
& Co.. 1012 Walnut street, Philadelphia, Pa. 1902.
The necessity for accurate diagnosis
in the practice of medicine is so appar-
ent to every intelligent physician that
no channel from which knowledge can
be gleaned is now overlooked. The
examination of the urine as a means of
el ucidating pathological phenomena
is now recognized as one of the phy-
sician's most useful aidb. The object
of the above book is to popularize this
line of investigation by simplifying the
methods of examination. As a practi-
cal guide to the student and physician
in this branch of science this little
book stands without a rival.
The Plague op Lust, Being a History of Venereal
Disease in Classical Antiquity. By Dr. Julius
ROSENBAUM. In two volumes. Published by Charles
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87
CaningtoD, Esq., 13 Faubourg Montanartre, Paxis,
France.
To lawyers, physicians, students and
specialists in sexual diseases this book
wfll prove of the highest value and is
worthy of a special place in their
library. Whilst the discussion of this
subject should only be permitted under
the most rigid restrictions, the study
of anthropology is an indispensable
part of a professional education. The
value of such knowledge must be meas-
ured by the use made of it. If the
lawyer or judge can more intelligently
and justly interpret and administer the
law* by possessing a thorough knowl-
edgeof sexual perversions and vagaries,
society is benefited. If physicians are
rendered more capable of treating dis-
ease by a thorough knowledge of the
unspeakable sexual abominations prac-
ticed by the different races of people,
suffering humanity is the beneficiary.
The author, in faithfully and truth-
fully portraying the foulness and sin-
fulness of lust, has performed a cred-
itable task. It remains for those who
read this book to make a proper use of
the information thus acquired.
Cakckb ot the Utkrcs, a Clinical Monograph on
ITS Diagnosis and Treatment. By Arthur H. N.
Lbwers, M. D., Lond., F. E. C. P., <Liond. Price,
$3.00. net. Published by P. Blakiston's Son & Co.,
1012 Walnut street, Philadelphia, Pa. 1902.
The above clinical monograph will be
read with morethan usual interestby the
general practitioner as well as specialist
in female diseases. The author deals
with this diflScult subject from a prac-
tical and conservative standpoint. He
makes no extravagant claims for sur-
gical methods of treatment, but main-
tains that encouraging results can be
attained in no other way. He urges
early diagnosis and prompt removal of
diseased tissues. He insists upon the
necessity of radical operative pro-
cedure as soon as the nature of the
disease is recognized, and cites cases
in which operation produced both tem-
porary and permanent relief. Formerly
cancer was so uniformly fatal in its re-
sults that an accurate diagnosis was not
considered important, and its an-
nouncement to the patient amounted
to a death sentence which was not ad-
visable, but now with this known re-
sults of early operative measures, con-
ditions have changed.
Hand-Book of Medical and Orthopedic Gymnastics.
By Anders Wide, M. D. Second revised edition.
Published by Fonk & Wagnalls Co., New York City.
1902.
This most excellent volume will
prove helpful to the medical practi-
tioner in many of the trying diseases
which confront him. Many of the
diseases of the circulative and nervous
system yield reluctantly to medicine
alone. In such cases gymnastics and
massage are valuable supplements to
medicinal treatment. It seems strange
in this era of research and discovery
that this branch of science has been so
generally slighted by the medical pro-
fession. The circulation of this book
among progressive members of the
medical profession will not only facili-
tate their work, but will result in a
benefit to suffering humanity. Price,
$3.00.
The Pocket Reference Book and VisiriNa List, Per-
petual. Published by J. H. Chambers & Co., St.
Louis. 1903.
Two Hundred and Fifty Thousand Miles of Travel*
IN Many Lands.
You cannot afford to miss this op-
portunity to accompany Mr. Burton
Holmes on his personally conducted
Easy Chair journeys in ten volumes,
magnificently illustrated from four
thousand original negatives by Mr.
Holmes. These journeys may be taken
at small expense by addressing the
Knega Co., Fine Arts BIdg., Chicago.
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38 Therapeutic Suggestions.
THERAPEUTIC SUGGESTIONS.
TREATMENT OP ECZEMA.
With proper attention to diet, a total
abstinence from the use of water on
the affected parts of the skin, by bath-
ing or otherwise, a proper combination
of arsenic with other reconstructives,
in anemia or debilitated states of the
system, and suitable topical applica-
tions, we may look for speedy and sat-
isfactory results. A very excellent
local treatment consists of the free use
of Glycobenphene (Heil). It allays
pruritus, relieves inflammation and
gradually removes the infiltrated prod-
ucts of inflammatory action.
Glycobenphene possesses qualities
which render it efficient as a topical
application in all forms and stages of
cutaneous irritation or inflammation.
ANASARCIN IN THE TREATMENT OF
MERCURIAL DROPSY.
As dropsy results from many causes,
but is seldom attributed to mercurial
poisoning, the following clinical case
may be of some interest to the profes-
sion:
H. M., age twenty-five, before con-
sulting the writer had undergone a
mercurial course of two months for a
syphilitic infection. Towards the close
of the mercurial treatment he became
suddenly anasarcous. He was weak
and anemic, but free from any symp-
toms of venereal disease. The urine
was scanty and high colored, deposit-
ing a lateritious sediment. It was also
charge<l with serum. He complained
of a cough and pain in the side. He
was placed under the following treat-
ment: Anasarcin tablets — one three
times a day; fifteen drops of tincture
of iron three times a day, alternately
with the tablets. He was also given a
small dose of Rochelle salts every sec-
ond day. Treatment continued thirty
days, with complete recovery and dis-
charge.
TREATMENT OP ULCERS.
IrriUiting applications should not be
applied as a dressing under any circum-
stances, nor should undue . pressure of
a bandage be exerted on the iiTitable
surface when it is used as a support to
the weakened tissues. Offensive dis-
charges should never be imprisoned by
improperly devised dressings, as their
septic influence would materially re-
tard the healing process. Before cura-
tive treatment is instituted thorough
disinfection of the ulcer and surround-
ing parts is indispensable. To accom-
plish this a considerable area of skin
surrounding the ulcer should first be
disinfected by shaving the part and
thoroughly scrubbing it with soap mini
warm water, previously sterilized by
boiling. If the granulations are ex-
uberant, soft and oedematous, they
shotild be scraped with a sharp spoon.
Now pack the ulcer with lint dipped in
a solution of Tyree's antiseptic pow-
der (two teaspoonfuls of the powder
to sixteen ounces of distilled water).
This dressing should be changed twice
or three times a day for two cr three
days, or until satisfactory results are
obtained.
OBSERVATIONS ON AN/BSTffBSK OP
THE DRUM MEMBRANE.*
By Geo. B. McAuliffe. A. B., M. D.
The majority of clinicians do not be-
lieve in trying to obtain local an«s-
thesia of the membrana tympana.
Their deductions have been drawn io
the main from the futility of using co-
caine for this purpose in the external
auditory meatus. It is but rational to
believe that nature protects the tym-
panic cavity from the effects of fluids
dropped by chance or design into the-
external canal. This protection is
given by the dermal layer of the drum
* Abstract of a paper read before American Otological
Society at New London, Conn., July 7, 1902.
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To Prevent Bursting of H, O, Solution Bottles
Atitomatic Safety Valve Stopper
Refer to National Druggist, of St. Louis, Mo., April, IWl
NO WlRjE NO BUKISTING NO LOUD POPPING
HYDROZONE
(Yields 30 times its own
Volume of active oxygen-
near to tte condition of
••OZONE")
HARHLBSS, POWERFUL BACTBRiaOE AND PU5 DESTROYER
GLYCOZONE
(C. P. Glycerine combined witli ozone)
HARriLESS AND nOST POWERFUL
HEALIMQ AOENT
SiK ce aaJ B lly need in the treatment ef Diseases of the Nose, Throat
Chest and noutli.^lnfiamaiatory and Contagious Diseases ef the
Alimentary Canal«— Diseases of the Qenito-Urinary Organs,
Women's Diseases. O p e n Sores.— Pundent Diseases
of the Ear.— Skin Diseases, Etc.
MARCHAND'S EYB RALSAM
CORES QUICKLY ALL IIIFLMilATDftY AND COflTACIOIfS DISEASES OF THE EYES
Send for free J 10-page book, 16th edition— •• Rational Treatment of
Diseases Characterized by the Presence of Pathogenic
Germs "—containing 160 clinical reports by leading
contributors to medical literature.
Physicians remitting 50 cents wHI receive, express charges prepaid, one
complimentary sample of each, •• Hydrozone" and ••Glycozone."
HYDROZONE is put up only in extra small, small, medium and large size bottles
bearing a red label, white letters, gold and blue border, with my signature.
GLYCOZONE is put up only in 4-oz., prepaked only by
8-oz. and i6-oz. bottles bearing a yellow ^^ |. , ^ -
label, red and blue border, vith my Jkr^DCSLAtAJ^y^W^Ul^^^
signature.
Cbemlst and dradtiate of the "Ecole Ontrale
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Mention this Publication 57-59 PRINCE STREET, NEW YORK
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40
Therapeutic Suggestions.
membrane — a skin without glandular
action or hair, acting only as a shield
fdr the layers beneath,
Jacques, by utilizing the selective
action of methylene blue, mapped out
the nerve plexus in the middle layer of
the drum membrane. The nerves
spread out in radical meshes from the
periphery — mostly from above. In the
deeper portion of the dermal layer de-
tached bundles run in different direc-
tions and end in apparently sensory
end tips.
The mucous membrane of the Eu-
stachian tube and of the tympanic cav,-
ity get their main nervous supply from
the same source — the glosso-pharyn-
geal.
From a consideration of these facts
we see that the external dermal layer
has very little to do with the sensitivity
of the drum membrane, and that most
of the medicines dropped into the ear
or applied to the drum, membrane have
little effect until they nullify the shield-
like action of the skin covering.
The fact that refrigeration does not
extend deeply enough to desensitize
the membrane demonstrates the truth
of the former of the above mentioned
conclusions. Furthermore, it cannot
be localized to the track of the in-
tended incision. The refrigerating
sprays need a space of a few inches to
secure evaporation. This would bring
under its action the whole membrane
and canal. I tried to get a tip devised
for spraying ethyl chloride on the re-
gion of the membrane selected for
operation, but was not successful. The
application of the spray to the sensi-
tive canal and the subsequent thawing
are very painful. I have thought that
if liquid air could be applied, as it is
claimed, by a cotton applicator, it
would be the ideal refrigerant knife
for the membrana tympani. Unfor-
tunately, too, refrigerants interfere
with healing and may cause slough.-
ing.
Various preparations like Bonain's —
menthol, carbolic acid and cocain —
depending for their action principally
on the carbolic acid, have been used.
More or less success has been re-
ported. I do not believe that the an-
aesthesia obtained by this class of
cauterants is ever complete, for rea-
sons given above.
Fluids which disturb the osmotic
equilibrium of the drum membrane and
produce minute solutions of continuity
in the dermal layer, thereby allowing
cocain or its succedanea to reach the
nerve filaments, are the best we have
at present for use in the external
canal.
The conditions favoring this applica-
tion of cocain are : ( 1 ) The removal of
foreign substances and loose scales-
from the drum membrane and canaL
(2) Dehydration of the outer layers of
the membrane — a desiccation which
causes molecular contraction and inter-
stices through which the ansesthetic
can reach the deeper parts and nerve
terminations. (3) The induction of
endosmosis. The first condition is met
by the use of hydrozone, which is
stronger and better than any other
kind of H202 preparation'in softening
and boiling oi^t the debris of the canal
and in lessening the resistance of the
dermal layer. The hydrozone is sub-
sequently mopped out by cotton appli-
cators or syringed from the canal.
The second and third conditions are
met by the use of alcohol and aniline
oil. The latter is absorbed more slowly
and its effects last longer than the
former. The solutions used are five
to twenty per cent of cocain in equal
parts of absolute alcohol and aniline
oil. Anaesthesia is gained in ten to
fifteen minutes. The disadvantage of
the solution is that the aniline oil is
toxic and obscures the field. The ex-
ternal canal is generally filled to en-
sure osmotic instability and certainty
of penetration. The toxicity can in a
great measure be prevented by not
filling the canal, but by applying to
the drum membrane a small wad sat-
urated with the solution and by mak-
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Two EXAMPLES
OF THERAPEUTICAL MERIT :
OF INTEREST TO PHYSICIANS
Pil.
Pil.
Antiseptic Comp.
Chalybeate Comp.
WARNER
WARNER
FORMULA
FORMULA
Sodium Sulphite, 1 gr.
SalicyHc Acid, 1 gr.
Pv. Capsicum, 1-10 gr.
Pepsin Conc't, 1 gr.
Ext. Nuc. Vom. 1-8 gr.
Mass Cha'vbeafe, 2>^ grs.
Ext. Nuc. Vol. 1-8 gr.
m Ft. Pl\. No. j.
SUGAR-COATED ONLY PINK TINT
Very efficacious in Dyspepsia
The best method for the adminis-
and Intestinal Indigrestion, and
tration of iron in an assimilable
especially valuable in caaes of
form to which is added the tonic
mal-aesimilation of food.
effect of the Nux Vomica."
Specify "Warner & Co." when prescribing
Specify '•Warner & Co." when prescribing
WB MAKE THE MOST SOLUBLE HYPODERMIC TABLETS OFFERED ;
SEND FOR A SPECIMEN.
WM. R. WARNER & CO.
PHILADELPHIA
NEW YORK
CHICAGO
NEW ORLEANS
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42
Therapeutic Suggestions.
ing only one application. The obscur-
ation of the field by the dark oil will
then be less, and the solution can be
more easily raopped away.
ACTION OF lODIPIN ON THE VASCULAR
SYSTEM.
The influence of iodine on absorption
and its specific action on the vascular
system have been frequently discussed.
Iodine causes a dilatation of the pe-
ripheral vessels. The utility of the driig
is unfortunately hampered by nuraer-
rous injurious collateral effects. This
drawback often compels us to avoid
iodine even in the face of urgent in-
dications. Recently, iodipin (iodized
sesame oil) has been shown to be a
most efficient substitute for iodine,
equally potent and free from toxicity.
Dr. Richard Thaussig* has inaugurated
clinical experiments with iodipin, se-
lecting affections which make a vascular
dirug-action desirable, such as asthma,
arterio-sclerosis, syphilitic endarteritis
and chronic lead-poisoning.
The remedy was administered in-
ternally and hypodermically. The oily
taste often interferes with inhibition by
the mouth, and, when large doses are
taken some manifestations of iodism
are apt to occur, probably as a result
of rapid absorption. This absorption
takes place in the small intestines,
where iodipin is split into its compo-
nents, iodine and sesame oil. Iodipin
may be given per rectum, but the ab-
sorption is very slow and the thera-
peutic action often inadequate.
By far the best route is the hypo-
dermic. For this purpose the 25-per-
cent preparation is employed. Injected
with aseptic precautions, the drug pro-
duces no local reaction of any signifi-
cance. The usual single dose in the
author's cases was five drams on the
average, one injection being made
every fourth day. The therapeutic
results were similar to those obtained
• Wiener Med. Woch., 1902, No. 29.
by giving the alkaline iodides. Toxic
manifestations were occasionally no-
ticed, but they were mild and followed
very large doses.
A most agreeable feature of the new
drug is its influence on the nutrition.
Many patients gain in weight while
taking iodipin. This may be due to its
fatty component, and contrasts favor-
ably with the usual cachectic conse-
quences of prolonged iodide medica-
tion.
The author finally emphasizes the
beneficial action of iodipin In lead-in-
toxication. Probably this effect is due
to the influence on the abdominal vas-
cular system.
Iodipin, concludes the author, pos-
sesses considerable value, since it ena-
bles us to supply iodine to the diseased
tissues for a long time, without pro-
voking a specific intoxication.
CLINICAL LECTURES ON DISEASES OF
THE SKIN.
The Governors of theNew York Skin
and Cancer Hospital announce that Dr.
L. Duncan Bulkley will give a fifth se-
ries of clinical lectures on diseases of
the skin in the out-patient hall of the
hospital on Wednesday afternoons,
commencing January 7, 1903, at 4:15
o'clock. The course will be free to the
medical profession.
FOR SEBORRHOBA OF THE SCALP.
B^ Sulphuris „ ..... 5 iss
Vaseline g j
M. ft. ungt. Rub on scalp at night.
Every morning sponge the scalp with
the following lotion :
gt Tr. canth gss
Spts. ammon. arom g ss
Lig. pot. arsen.* g as
Glycerine 3 ij
Alcohol 5 ij
Aqua rose q. s, to make gviij
M. Big. — Sponge the scalp well every morning.
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JUST NOW
when the debilitated and
poorly nourished are subject
to coughs and colds, the
remedy of most value is
GRAY'S" —TONIC
COMP.
Its Specific action on the
respiratory organs is second
only to its unique value in
malnutrition and general debility
THE PURDUE FREDERICK CO.
No. 15 Murray Street, New York
Sander & Sons' Eucalyptol
The MOST POWERFUL and RELIABLE ANTISEPTIC KNOWN
Is Antiphlogistic, Analgesic, Antispasmodic, Non-Poisonous, Non-Irri-
tating, and possesses all the healing qualities of Balsamics.
Different Forms of Tinex and Other Parasitoses:
Paint with 10 to 20 per cent alcoholic solution of Sander^ s Eucalyptol,
Eczema^ Acne, Dermatitis, Pruritus, etc.:
20 mtn. {in acute) to 60 min. {in chronic) of Sander^ s Eucalyptol to the ounce of
Ung, Zinci,
Ctiancroids, Ulcerating Ctiancres, Ulcers and Septic Wounds:
Add 10 drops of Sander's Eucalyptol to a pint of warm water and wash parts:
then paint the ulcer with Sander's Eucalyptol, full strength, and apply occlusive
dressing.
To avoid the irritation so frequently following the application of the common products of
Eucalyptus found in the market, and to assure certain therapeutic results, we respectfully re-
quest to always specify ** Sander's Eucalyptol** when prescribing, or to obtain it in the originate
package from meyer Bros, Drug Co., St, Louis, Mo.
Sample and literature of Sander and Sons' Eucalyptol, gratis, through Dr. San-
der, 88 Lincoln Aventie, Chicago, 111. Meyer Bros. Drug Co. , St. Louis, Mo. , Agents.
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44
Selections.
SELECTIONS.
URiNB PROM BACH KIDNEY.
Valentine {Medical Record ^ October
25, 1902). — Ureteral catheterism, in-
disputably the best, has its limitations,
and also a goodly number of oppo-
nents. For it the bladder must have a
capacity of at least 50 c. c, must not
be a bleeding bladder into which one
or the other kidney is pouring blood
too rapidly for the irrigating cysto-
scope to wash away, the bladder walls
must not be desquamating large shreds,
and the ureters must be large enough
to admit the smallest catheter, besides
other conditions evident upon a mo-
ment's thought.
Ureteral catheterization demands
continual practice, greatest possible
skill, acute vision and most delicate
manipulative tact. For this reason
segregation occupies a distinct place in
urology. Harris' and Downes' instru-
ments for segregation are founded on
the principle of the water-shed, and
present distinct inconveniences when
used upon the male. Cathelin's method
which is here fully described by Val-
entine is considered by him to possess
decided merits. [Cathelin printed a
description of his instrument in the
Presse Medicale (No. 48, June 14,
1902), and has given the details of his
technique and his principal results in
the Ann. des MaL des Org. Genito-
Urin. (July, 1902)].
The principle of the instrument is
based upon pushing into the bladder a
soft rubber membrane which adapts
itself to the wall, and which is grasped
by the bladder, thus dividing the vis-
cus into two halves.
useful remedy to render the urine
9LC\A.^ Exchange.
ORCHITIS.
Lutaud (JkTedecine) combats the p^in
of orchitis by the administration of
cachets containing seven and one-half
grains of sulphate of quinine. In the'
majority of cases pain is arrested after
the first dose, and it is unnecessary to
give an injection of morphine. At the
same time the following is applied lo-
cally :
It Methyl salicylatis.. ^ Jyj
Guaiacol 3J
Vaselini Jj
M. Sig. — Apply locally once or twice a
day. — Ex.
Dr. William P. Loth reports three
cases of tinea circinata in adults,
treated at the Dermatological Clinic of
Professor Hardaway, St. Louis Poly-
clinic. One patient, presenting on the
right arm small, nodular masses and a
number of follicular pustules, was
cured by the application of a five per
cent, xeroform ointment; the second,
in which the extensor surfaces of both
hands were covered with vesicles and
vesico-pustules, yielded to an ointment
containing four per cent, each of sul-
phur and balsam of peru, and the third
having on the outer and extensor as-
pect of the left wrist a thick group of
acuminate pustules, was treated with
equal parts of trikresol and alcohol
three times weekly, a three per cent
xeroform salve being applied in the
interim, and only a slight scarring re-
mained to mark the site of the lesion.
In chronic catarrh of the bladder,
when the urine is loaded whith phos-
phates, benzoate of ammonium, in
doses of ten to thirty grains, is a
THE TREATMENT OF NEVUS, OR
BIRTHMARKS.
A simple and safe method of treat-
ing nevi and port-wine marks consists in
exerting pressure around the nevus by
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ANASARCIN
i
i
(Oxydendron-Sanibucu5-5cilla Compound.)
A SPECIFIC FOR DROPSIES
Doctor:—
If you know a thing to be a fact, it is not wrong or
unethical to say so. Neither does it smack of quackery or
Charlatanism and should not shock the sensibilities of any,
however refined, cultured or zealous of medical ethics for us
to claim that ANASARCIN is a specific in dropsies, when
clinical experience has demonstrated such to be a fact. If
quinine is a specific in malaria, much more is ANASARCIN
in dropsies resulting from disease of the heart, liver or
kidneys, because that a trial of it in hundreds, yea, thousands
of cases has not resulted in a failure known to us where
directions have been followed.
Besides being a specific for dropsies, it is a permanent
cure in the conditions mentioned when begun early and
continued a sufficient length of time, i, e., until the diseased
organs regain normal function. ANASARCIN is composed of
the active principles of Oxydendron Arboreum, Sambucus and
Urginea Scilla, and is sold exclusively to physicians or
druggists for physicians. Trial box free with literature and
testimonials furnished physicians on application.
I
I
ADDRESS
The Anasarcin Chemical Company
WINCHESTER, TENN,, U, S. A.
=^-^LONDON AQBNTS-
1%%^
Tbos. Christy A Co., 4-10 '12 Old Swan Lane, Upper Thames St., B. C.
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46
Selections.
an encircling ring in order to arrest the
circulation to and from the part and
then slowly inject five to seven minims
of rectified spirits of wine with an ordi-
nary hypodermic syringe. The result
is to harden the tissue and to cause the
nevus to shrink and disappear. In
treating nevi of large dimensions more
than one injection could be given at
the same sitting, or at short intervals
of time in different parts of it ; the ab-
sorption in one part could be taking
place while another part was being
prepared, bearing in mind the effect of
alcohol upon the system. This method
has the advantage of being easy of ap-
plication, and there are few practi-
tioners who are not possessed of all
the material needed ; if not it is read-
ily procurable, and with ordinary care
it will not, I think, prove dangerous.
Care must be used that the syringe is
perfectly void of air before injecting
the agent. — Dr. T. M. Holgate in
Pediatrics.
ECZEMA iN iNPA^TS.
In certain cases of eczema in infants
the effect produced by a thorough
and continuous use of a zinc ointment
containing twenty grains of ichthyol
and fifteen or twenty of salicylic acid
is certainly remarkable and undoubt-
edly much greater than from either
the zinc or ointment alone, or when
combined only with the salicylic acid.
— Dr, Bulkley.
TREATMENT OP PRURiTUS VULV^,
Siebourg (quoted in the American
Journal of Obstetrics y October, 1901)
has had good results in the treatment
of some cases of pruritus vulvae by sub-
cutaneous local injections of weak solu-
tions of cocaine and carbolic acid. He
then attempted to accomplish the same
purpose by simple injections of salt so-
lution. He believes that local anes-
thesia is caused by the pressure of the
injected fluid. — Therapeutic Gazette.
INDEX
Original Articles. page.
In the Present Status of Bacteriology Can
its Relation to Cutaneous Pathology be
Accurately Defined? 1
Notes on Diverticula of the Male Bladder.
By Louis E. Schmidt, M. Sc, M. D 13
Clinical Remarks on Some Advanced Forms
of Urethral Stricture Treated by a Com-
bined Urethrotomy and Perineal Section.
By Reginald Harrison, F. R. C. S., Eng-
land „ 16
Endovesical Surgery with Special Refer-
ence to Cystoscopy and Ureter Catheter-
ism. By F. Kreissl, M. D , Chicago,
Illinois 18
Original Articles. page.
Epicarin as an Antipruritic. By Max
Reichmann, M. D., Chicago, Illinois 23
Koilonychia and its Successful Treatment;
with the Report of Some Cases. By A. H.
Ohmann-Dumesnil, St. Louis 24
Urticaria, its Vagaries and Treatment. By
S. C. Martin, M. D., St. Louis 32
Pathogenesis and Treatment of Diabetes
Mellitus 33
New Pubucations 36
Therapeutic Suggestions 38
Selections 42
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A BI-MONTHLY MAGAZINE DEVOTED TO THE CONSIDERATION OF CUTANEOUS MEDICINE
VENEREAL DISEASES AND QENITO-URINARY SURGERY.
EDITORS
S. C. MARTIN, M. D. G. M. PHILLIPS, M. 0.
P*tOrinOR or OrRMATOLOOV in THC BARNCS MIOIOAI. OOLLIOI PROriMOR OP OCNITO'URmARY DISIAMS ST. LOUIS OOtUOl OP
rr. LOUIS. PHYSICIANS AND SURQIONS.
MANAGING EDITOR
S. C. MARTIN. Jr., M. D.
SUBSCRIPTIONS AND ADVERTISING.
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Address all communications, correspondence, books, matter regarding advertising, and make all checks, drafts and post-
office orders payable to
AMERICAN JOURNAL OF DERMATOLOGY
fidelity Buiidtng. St Louis. Mo . U. S. A
Vol,. VII.
MARCH, 1903.
No. 2.
ACTINOMYCOSIS AND X-RAY THERAPY.*
By M. L. Hkidingsfbld, Ph. D., M. D.,
Prof. Dermatology, Laura Memorial College; Clinical
Lecturer Dermatology, Miami Medical College;
Dermatologist to Presbyterian Hospital.
The following case of actinomycosis
is of particular interest, not only be-
cause of its well-defined type and char-
acteristic appearance and history, but
also because it demonstrates the ineffi-
cacy of x-ray therapy in this class of
affection and the excesses to which, on
occasion, it can improperly be carried.
Mr. J. H., aged sixty-two years, a
farmer by occupation, but for the past
six years a dairyman, and the present
owner of twenty-three cows. In De-
cember, 1900, he consulted a dentist
relative to a small, painful nodule sit-
uated on the buccal mucous membrane,
in proximity to the right lower molars,
and whose surgical removal was fol-
lowed by brief temporary improve-
ment. The nodule retained its pain-
*ReT>orted Cincinnati Academy Medicine, January
26, 190d.
ful and inflamed character, and soon
assumed such proportions and charac-
ter that the dentist advised a consulta-
tion with one of our most pro.minent
homeopathic surgeons, in June, 1901.
The surgeon advised the extraction of
all the lower teeth in proximity to the
affected area, and which were at that
time the seat of considerable neuralgic
pain. The extraction was not fol-
lowed by any marked improvement,
and the patient sought his family phy-
sician, who, in January, 1902, advised
a consultation with one of Cincinnati's
most prominent regular surgeons ; thi&
surgeon promptly pronounced the con-
dition malignant disease of the jaw,
and urged the removal of the right
half of the lower jaw, stating that thiif
would be the only means of prolong-
ing his life longer than a year, and
possibly not longer than six months,
even with an operation. Patient was
greatly depressed by the unfavorable
character of the prognosis, and su-
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Original Articles
preme resignation to his fate deterred
him from undergoing the operation.
In March, 1902, patient came under
the care of an x-ray specialist, who,
■during a period of almost three
months, made twenty-five prolonged
And rather intense exposures. This pro-
longed treatment, other than inducing
XI rather severe and annoying derma-
titis, did not seem to exert any marked
influence, either towards checking its
progress, inducing retrogres s i v e
changes or alleviating the subjective
pain and distress. After an interval
of three months, during which time
the patient did not receive special at-
tention, patient consulted a second
x-ray specialist, who proceeded to give
him another course of x-ray therapy,
of twenty exposures, covering a period
of eight or nine weeks, and which was
followed by the same negative results,
AS far as two additional months of ob-
servation (during which time the pa-
tient was again without special atten-
tion) permit us to judge.
The now thoroughly disheartened
And discouraged patient once more
sought the care and attention of his
family physician. Dr. J. G. Walton, of
Home City, with whom I saw the case
in consultation for the first time, De-
<5ember 17, 1902; at this time the skin
covering the lower maxilla on the right
side for a distance of several inches
upward on the cheek, and downward
on the neck from the chin to the an-
terior border of the ear, was diffusely
infiltrated, semi-fluctuating, somewhat
doughy in character and deep brownish
red in color. Above the right lower
maxilla, at about the junction of the
anterior two-thirds with the posterior
two-thirds, was a large ulcerating fun-
gating ulcer, size of a silver one-half
dollar, with thick indurated borders
and base, and filled with masses of dense
granulations. Beneath the jaw were
four or five long, slender sinuses, from
which there constantly oozed, in in-
creased amount on pressure or on mo-
tion of the jaws, a considerable quan-
tity of thin, sero-purulent discharge,
which contained a number of sulphur-
yellow colored flakes, which, when
macerated, stained and placed under
the microscope, revealed characteristic
central body and radically disturbed
mycelia of the ray fungus. In addi-
tion to the diffused character of the in-
filtration, foci of softening and sinus
formation, characteristic discharge, in-
sidious onset, mucous membrane ori-
gin, maxillary involvement, predis-
posed occupation, readily detected fun-
gus, remained the fact that the patient
two years previously was the possessor
of a lumpy jawed cow, all of which
evidence, overwhelming and conclusive
in character, rendered the diagnosis
such a simple and easy matter that it
scarcely seems probable that it could
be overlooked. A portion of the bor-
der of the ulcer, which was removed
for histological examination, revealed
itself to be almost a pure type of epi-
dermal tissue, extensively hypeitro-
phied and proliferating, from pro-
longed character of the irritation and
inflammation.
Patient was placed on potassium
iodide, internally, on date of his first
visit, December 17, 1902, and iodipin
injections were instituted December
22d. On the date of the last consul-
tation, January 8, 1903, although his
general condition has been very se-
riously impaired by the excessive
drain, prolonged and painful char-
acter of his affection, the local im-
provement has been very marked, to
such an extent that the diagnosis is
not only confirmed, but sincere hope is
now also entertained that his recovery
will be both complete and permanent
in character.
The overlooking of the diagnosis in
such an apparent case is attributable
solely, I believe, to the excess to
which x-rav therapy is at present car-
ried. Man^ of the men who interest
themselves in this work believe it to
be such an unfailing remedy for almost
any form of inflammatory change.
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Ureter to the Bladder— Robinson.
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that a careful consideration of the nat-
ure and causes of the affection, and
therapy in its older, though possibly
antiquated garb, is of little or of sec-
ondary importance. So supreme is
their faith in the x-ray that at the
shrine of therapy, at which they wor-
ship, it is fast becoming the only god
which they invoke to their aid. Fort-
unately for medicine, though unfort-
unate for man and the ills to which
he is heir to, it is not the cure-all that
some imagine, and as the foregoing
case demonstrates. My experience
may be somewhat unique, but I am
strongly impressed that, though it is a
valuable agent, and though it occupies
an important, almost indispensable,
place in dermatologic therapy, it does
not possess the unfailing reliability
and efficacious power, even in the
treatment of lupus and epithelioma,
which it is commonly reputed to pos-
sess. I believe its aid is often invoked
when it is not required, and that its
action is at times decidedly delete-
rious.
Instances like the preceding case
will serve not only to bring x-ray
therapy into moderate disrepute, but,
oft repeated, will effect a harmful re-
action, from which, no doubt, it will
be a long time recovering. No one
can question, even at the present time,
but that it holds and is destined to
hold a very important, permanent and
indispensable place in dermatological
therapy, but at the same time it does
not possess the unfailing reliability
and efficacy which many of its most
ardent admirers claim for it. Itn
proper employment entails the careful
consideration of definite principles
which are being slowly elaborated, and
are not, as yet, fully established;
fundamental, and by no means the
least important of which, is the estab-
lishment of a correct diagnosis and
full consideration of, and not reckless
disregard for, the older and equally
efficacious and reliable methods of
treatment. It is fortunate for med-
ical science that definite principles are
involved, otherwise its employment
would be so simple and mechanical
Dr. Heidingsf eld's case of actinomyoosis.
that skill, knowledge, experience,
judgment and learning, and all the
gifted attributes and attainments
which contribute so much worth to-
wards making the study and practice
of medicine the most enlightened and
inspiring of all professions, could mean
little or nothing, and its practice could
be relegated to the merest tyro, quack
or mechanician, who, irrespective of
cause and nature of disease, could cure
ailment and restore health by the
mere turning of a switch.
22 West Seventh street.
RELATION OF TUB URETER TO THE
BLADDER.
Bt Btron Robinson, B. S., M. D., Chicago.
The relation of the ureter to the
bladder should be considered in two
segments — (a) extramuralis, and
(6) intramuralis. Both extra- and
intramural segments are of extreme
importance in obstetrics and gynecol-
ogy, especially in the large field of
vaginal hysterectomy.
(a) Extramural Segment, — This
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Original Articles.
It is located nearly one inch
distal to the external os. It
courses obliquely distalward one-
fa a 1 f to three-quarter inch
through the vesical wall, whence
it ends at the distal ureteral ori-
fice, forming one of the angles
of the vesical trigone. The
course of the ureters through
the vesical muscularis and fibrosa
is not far from parallel, but on
arriving at the vesical mucosa
they rapidly converge medially
between vesical muscularis and
mucosa — i. e., there is a slight
angle of the intramural ureter*
at the junction of vesical, mu-
cosa and muscularis. Accord-
ing to my dissections, the vesi-
FiQ. 1.— Illustration of the relation of the ureter to bladder, vaffina ^,,i fihrrkno anr\ miifi/^nlaritt fnnir>Q
and cervix uteri. 1, Arteria uterina arisinR from the internal iliac. Cai UOrOUS aUQ mUSCUiariS lUUlCS
2, Distid arteriouretera][^croB8ing. 3, Cervical loop. 11 is placed on and UrctCr do UOt blcud Or COal-
esce. The ureter is separated
the trigonum vesiciP. The
tween bladder and vagina.
extramural segment of ureter lies be-
corresponds in general to the vaginal
ureteral segments.
The extramural segment is the one
which is the more liable to trauma^
account of its intimate relation
cervical arterial loop or the
portion of the pelvic floor se;
the utero-ovarian artery. T&
mural portion is also the seg]
the ureter which is so intimate
lated to the vagina. The extramura
segment possesses a strong fibro-muri-
cular ureteral sheath which accompa-
nies the ureter through the bladder
wall. It bends medial ward before it
ends in the bladder.
The extramural portion is applied
practically to the dorsal, lateral and
distal surface of the bladder (base).
One inch distal to the os uteri externum
the ureter penetrates the bladder wall.
It lies in an extensive bed of areolar
tissue and veins.
(b) The Vesical Intramural Por-
tion.
The intramural, intravesical or intra-
parietal portion is so named by reason
of its location in the bladder wall. It
is the terminal portion of the ureter.
from the bladder wall by a visible
zone of connective tissue, which insures
independent function of bladder and
ureter — i. e., the bladder can contract
^whilethe ureter continues to
tents in the bladder. In
worCThrNjc ureter can pour itscon-
padder, but the function
sralve in the bladder wall
10 urine to regurgitate
'ureter in any state of the
/systole or diastole. The lo-
cation of the intramural portion of the
ureter corresponds to the junction of
the proximal one-third with the dis-
tal two-thirds of the ventral, vaginal
wall. In some cases the junction is
practically in the middle of the vaginal
wall. Indication of folds on the vag-
inal wall, as noted by Powlick, pre-
sent a triangular outline correspond-
ing to the vesical trigone. The ure-
ters project the folds vaginalward.
The summit of the vesical trigone,
which is situated at the level of the
orificium urethrse internum, will be
separated from the distal ureteral ori-
fice by about one inch (resting), or
one and one-half inches (distended)
bladder. At the entrance of the ure-
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Ureter to the Bladder— Robinson.
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ter8 into the external bladder wall
they are separated about one and one-
half inches (resting), and at their en-
trance into the internal bladder wall
they are separated about one inch
(resting). The ureter courses for con-
siderable distance beneath the vesical
mucosa.
The pars intramuralis is the one-half
inch of the fixed distal end of the ure-
ter. It lies within the vesical wall.
The ureteral sheath lessens as the ure-
ter passes with it obliquely through
the bladder wall, almost disappearing
at the mucosa. The distal ends of
the two ureters and the proximal end
of the urethra together form the tri-
gonum vesicae ( Lieut audii) an isos-
celes triangle, one inch in area of fold-
less mucosa, containing the chief ves-
ical sensory nerves and rich vascular
supply.
The intramural portion opens into
the bladder one-half inch ventral to
the portio vaginalis., It is short,
oblique, narrow (the second most con-
stricted part of the ureter), having a
length of one-third to one-half inch.
The portio intramuralis ureteric
passes for nearly three^fourths of an,
inch through the vesical wall, and in-
dependent of it, insuring- separate i^nd
independent action of both ureter and
bladder wall. The vesical segment of
the ureter, consisting of the intra-
mural and extramural portions, must
always be of the highest importance
with regard to the surgical interven-
tions on the pelvic viscera. In hys-
terectomy, especially per vaginam, the
cervix uteri being drawn distal ward by
traction forceps, alters the normal
ureteral and cervical relations. Draw-
ing the uterus distalward applies the
ureter more closely to its lateral cer-
vical borders as well as to the sides of
the bladder.
The ureteral fistula in the intramu-
ral segments is difficult to heal. I
have observed one in practice that
lasted three years, in spite of numer-
ous operations. The extramural seg-
ments in the resting bladder are sepa-
rated about one and one-half inches,
but in a well-filled bladder may be sep-
arated over two inches. Under favor-
able circumstances the vesical segment
of the ureter can be palpated per va-
ginam. The intramural segment is
important, as it is the second narrow-
est sphincter of the ureter, and calculi
are liable to lodge in it. It is also the
point to effect ureteral catheterization.
The Distal Ureteral Orifice.
The distal ureteral orifice is visible to
the naked eye, generally located on a
mammilliform process at the proximal
lateral angle of the trigonum vesicse.
Sometimes it does not present any
elevation, but, on the contrary, a de-
pression in the vesical mucosa.
Its form is generally an obliquely lat-
Fig. 2. — A, B, D, E, F, represents the distal end of the
ureter as it appears in the bladder with various shapes
and distance from each other. 1 and 2 are the distal ure-
teral orifices, and 3 is the oriflcium ure three internum. C
is an illustration to show how the ureter penetrates the
vesical tunics. 1, Tunica fibrosa vesicie. 2, Tunica mus*
cularis vesicoB 3, Tunica mucosa vesicie. 4 to 5 repre-
sents the ureter piercing the coats of the bladder. The
end of the ureter at 5 is made to bend too sharply, as it
should course for considerable distance under the vesical
mucosa. From 4 to 5 is about three-fourths of ^n inch.
eralward-directed oval slit cne-eighth of
an inch in diameter, with the sharpest
point of the oval pointing distalward.
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Original Articles,
The thickened linear mucous
ridge connecting the ureteral
orifices at the base of the tri-
gone is slightly convex distal-
ward, which again facilitates the
use of the catheter.
The trigone is a mobile or-
gan, and the distance of separa-
tion between the distal ureteral
orifices so vary in the distend-
ing (diastole) and contracting
(systole) bladder that the figures
given by different authors, to fix
the relation of the distal ureteral
orifices to the trigone, vary so
much as to lose their value.
If one takes a half dozen
authors, the distance given be-
tween the distal ureteral orifices
by one author will be one-half
or double that of the other.
Thus, one author will give the
distance between the ureteral
orifices as two-thirds of an inch,
Fio. 3. --Six illustrations of the various appearances of the distal _-^j M>rx^4-U^w» av«^ r.«^ ^r%t% fki«.^
end of the ureter in the bladder. 1 and 2, i3istal ureteral orifices. ^^^ anOtUCr, OUQ aUQ One-inira
3, Oriflciumurethne internum. The various appearances of the vesi- Jn/thAQ T found that the di*^-
tance between the distal ureteral
orifices varied remarkably in several
hundred autopsies, owing to the thinned
or thickened vesical wall, to the quan-
tity of the vessel contents, the ex-
tremes being two-thirds to two inches.
In general, the trigonum vesicae was
an isosceles triangle of one inch (rest-
ing) or nearly two inches (distended).
The distal ureteral orifices are reached
with facility by the finger in woman
subsequent to dilatation of the urethra.
To catheterize the ureter it may facili-
tate by following the oblique dorso-
lateral ridge of the trigone, when the
point of the catheter may fall in the
orifice.
The pars extramural! s vesicae is the
portion of the ureter that lies between
vaginal and bladder walls, in contact
with both, but can be freed from each.
The vaginal portion of the ureter is of
supreme importance, as it can be at-
tacked per vaginam for surgical inter-
vention, as the removal of ureteral
cal is here illustrated.
The orifice may, howevcF, be rounded,
punctiform or like the beak of a flute.
In this last condition the ureteral ori-
fice is limited proximally and distally
by a curvilinear mucous fold in the
form of a valve, constituted by the con-
tact of the borders of the mucous folds.
An extreme illustration of this valve
in the form of a bridle rein is noted in
the upper left-hand figure (illustra-
tion No. 3) surrounding an oblique
ureteral orifice. One can easily see
the advantages offered by this mechan-
ical arrangement to facilitate catheter-
ization. The elevated ridge produced
by the muscle of Jurie, the interure-
teral muscle connecting the ureteral
orifices, aids catheterization.
The ureteral orifices occupy the
proximal lateral extremities of the
base of the trigonum vesicae, and a
slight lateral mucous ridge exists which
facilitates the introduction of the
catheter.
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Ureter to the Bladder— Robinson.
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calculi, removal of stricture or repair
of ureteral fistula.
With the distention of the bladder
the extramural portion lies more in
contact with the bladder and is forced
lateral ward.
The proximal ends of the intramural
segments are separated about one and
three-quarter inches, the distal ends a
little over one inch. In empty blad-
der the distal ureteral orifices are
about one inch sepai*ated by filled blad-
der, they are from one and one-half
to two inches separated.
In empty bladder the portio extra-
muralis lies more dorso-ventrally ex-
tended, which makes the distal arterio-
ureteral crossing more distant from
the ureteral penetration of the blad-
der. If the bladder be filled the ar-
terio-ureteral crossing approaches the
bladder.
I found by injecting numerous ure-
ters from the bladder with canula that
most ureters entered the bladder in
^ sagital or dorso-ventral direction,
and that the transverse traversing of
the bladder by the ureter is an excep-
tion. Practically the transverse direc-
tion of the portio intramuralis ureteris
begins in the submucosa vesicalis, or,
perhaps, in the vesical muscularis.
To avoid trauma to the ureters in
vaginal hysterectomy, the bladder
should be forced proximalward and
the ureter proximalward and lateral-
ward. When the ureters leave the
lateral pelvic wall to pass to the blad-
der, they course adjacent to the pelvic
floor between the peritoneum and the
reflected parietal layer of the pelvic
fascia, which glides into the visceral
pelvic fascia. The ureters enter the
base of the bladder dorso-ventralward
surrounded by plexus venous.
Conclusions as Regards the Vesi-
cal Segment of the Ureter.
1. It penetrates the vesical wall
obliquely, especially the mucosa, for a
half inch. 2. It forms a perfect non-
regurgitating parietal valve. Urine can
enter a distended bladder, but not &
di'op can re-escape through the ureter.
3. The distal orifice is located at the
proximal external angle of the vesical
trigone. 4. The orifice is an obliquely-
directed, oval, mucous slit one-eighth
inch in diameter. 6. The oval mucous
slit is generally situated in a depres-
sion or in a mammillated elevation, oc-
casionally surrounded by a mucal fold
constructed in such an an-angement
that it facilitates uretheral catheteri-
zation. 6. The ureteral orifices make
their exit on a foldless mucosa contain-
ing the chief vesical sensory nerves —
the trigone. 7. The intramural vesi-
cal ureter penetrates the tunica fibrosa
and tunica muscularis of the bladder
wall independently, surrounded by its
fibrous muscular ureteral sheath. The
tunica fibrosa and tunica muscularis of
the vesical parietas are separated from
the intramural ureteral segment by
the ureteral sheath, a fibro-muscular
structure constituting a distinct macro-
scopic tissue zone between ureter and
bladder wall. Perhaps the space be-
tween the ureter and fibro-muscular
ureteral sheath is a lymph space facili-
tating mobility. 8. The fibro-muscu-
lar ureteral sheath accompanying the
intramural segment of the ureter, es-
pecially that penetrating the tunica
fibrosa and tunica muscularis vesicae, in-
sures separate and independent action,
function of ureter and bladder — e. g.<,
while the vesica urinaria executes its
diastole and systole the intramural ure-
teral segment independently acts or
functionates as usual. In other words,
the rhythm of bladder and ureters are
separate and independent in function,
even in the vesical segments. 9. The
distal ureteral orifices and the proxi-
mal end of the orificium urethra-inter-
num practically make an isosceles tri-
angle of one inch on a side. 10. The
distal end of the ureter, like the prox-
imal end, is mobile ; however, the dis-
tal end moves with the vesical trigone,
while the proximal end (calyces)
moves with the kidney. 11. Though
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the oblique valve arrangement of the
ureter in the bladder wall would not
absolutely prevent ascending bacterial
<iisease, yet when the ureter be trans-
planted in the tractus intestinalis,
when possible, the distal orifice of the
ureter should accompany it.
PRVRiaO AND PRURITUS,
By S. C. Martin. M. D., St. Louis, Mo.
The above diseases are still often
-confounded, although essentially dif-
ferent in every feature except that of
itching. Prurigo is a papular disease,
beginning usually in infancy and con-
tinuing indefinitely in its typical form,
while pruritus is a neurosis usually of
middle and advanced age, in which
there is no structural change of the
skin except such lesions as are sec-
ondarily developed from scratching to
relieve the excessive itching. Prurigo
is met with on the extensor surfaces
<5hiefly, while pruritus is mostly local-
ized or limited to some special part of
the body.
It seems strange that prurigo should
be so generally associated with pruri-
tus, which it does not resemble, and
never confounded with papular ec-
zema, which it so frequently imitates
in nearly every particular, especially
those forms which persistently defy
all plans of treatment. This is prob-
ably due to the fact that nearly all
text-books speak of it as an Austrian
disease and attribute its discovery to
Hebra. Hebra deserves the credit of
elaborating its clinical history, more
especially the worst form, known as
prurigo ferox, but I think it is going
too far to claim that Austria or siuy
other country enjoys a monopoly in
this type of skin disease. Any spe-
cialist of large experience in skin dis-
eases must know that it is not rare,
especially in large cities, to meet with
a persistently itching papular eruption
which in its clinical and anatomical
history furnishes an almost exact
picture of the disease described by
Hebra as prurigo.
The treatment of this disease is
more or less empirical. Attention to
hygiene, diet and improved nutrition
is paramount. The daily use of the
hot bath and free applications of tar
soap will give great relief. Wilkin-
son's ointment should be applied at
night for a week or ten days, the pa-
tient sleeping between blankets, and
at the end of this time a warm bath
should be taken. Antipyrin in doses
of two to three grains at short inter-
vals will diminish the itching. Crocker
advises full doses of cannabis indica
(tincture) for this purpose. Kaposi
recommends a 5 per cent, ointment of
napthol combined with oxide of zinc.
This is spread upon pieces of muslin
and applied to the limbs under a roller
bandage. Constipation should be
guarded against by the free use of
saline laxatives. Arsenic, iron and
strychnine in some cases may be em-
ployed with benefit. Cod-liver oil,
malt extract and bitter tonics, in con-
nection with the betterment of hygi-
enic environment, will enhance the
effect of local remedies.
Itching is a prominent symptom of
many cutaneous diseases, but it is sub-
stantially the whole of the disease
known as pruritus. It may occur at
any age, but is most common and
troublesome late in life. The nostrils,
anus, scrotum and vulva are the re-
gions most liable to be affected. It
may occur at any season of the year,
but the winter months are the favorite
time for its appearance.
The causes of pruritus are not always
easily ascertained. Gout, diabetes,
neurasthenia, jaundice, malaria and
dyspepsia frequently are the funda-
mental factors claimmg our therapeutic
recognition. The indulgence in alco-
hol, coffee, tobacco and improper food
is often injected into the current his-
tory of this disease as a contributing
agency. In old age the skin degener-
ates, wears out, and its innervation be-
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Third Act in the Drama of Syphilis— Robbins. 65
comes correspondingly impaired and
perverted. These changed conditions
provoke neuroses, and in most of such
cases radical cure is out of the ques-
tion. Palliation is all that can be
hoped for. The treatment must be
along rational lines. Narcotics' should
be seldom employed, and when neces-
sary, they should be used with great
care. Where a patient is prevented
from sleeping by the itching of this
disease, do not give opium. The
bromides will do better without pro-
ducing the injurious effects of opium.
Bulkely recommends cannabis indica
and gelsemium. A hot bath at night
with a free addition of salt will induce
rest. External applications are very
important helps. Fox recommends
chloroform liniment to allay the itch-
ing. He also advises the employ-
ment of carbolic acid for local anes-
thesia. One of his favorite prescrip-
tions is:
Ul Acid carbolic 20 parts
Glycerine 20 parts
Aquae ...^....ad 100 parts
This he cautiously applies as a lo-
tion, sometimes diluted to suit the
case.
My only objection to carbolic acid
is, it must be used in great strength to
secure anesthetic effects, and in this
form it is liable to be absorbed with
poisonous results. Chloral and cam-
phor mixed in equal parts will in some
cases give prompt relief. We also
have menthol, cocaine, salicylic acid,
corrosive sublimate and cyanide of po-
tassium, all valuable remedies to select
from, as occasion may require. Elec-
tricity is also an effective remedy well
worthy of trial. At best this disease
is equally troublesome to the patient
and the physician. It often exhausts
the patience of the former and baffles
the skill of the latter, and in some
cases takes its leave without the help
of either.
THIRD ACT IN THE DRAMA OF SYPHILIS.
By Hxnby Alfbxd Robbims, M. D.,
Professor of Dermatology and STphiloloiry In the Medical
Department of Howard University; Dermatologist
to the Washington Hospital for Foundlings.
Alfred Fournier, in his ''Lesons eur
la Syphilis,'* Paris, 1873, gives the
following striking analysis of the
''drama" of the apparition and de-
velopment of syphilis:
I^irst Act, — Contamination. — The
virus peneti*ates the organism by one
mode or another.
Second Act. — Production at the
point where the virus has penetrated,
and only here, of a lesion, known as
initial, which, for the time, constitutes
the only expression of the disease.
Second Interval. — Another period of
repose of the organism ; the initial le-
sion continues to be the only symptom
by which the disease is expressed.
Third Act. — Explosion of multiple
and disseminated lesions beyond and
outside of the seat of contamination.^^
This is the period of visible gen-
eralization of the disease.
The Apostle James says: * 'Behold
how great a matter, a little fire kin-
dleth." This text occurs to me when-
ever I look at the innocent-looking
chancre. When you first see it, it has
passed through the hatching stage —
the stage pf incubation. It has suc-
cessfully performed that role in the
first act of the drama of syphilis.
Experimentation proves to us that
the chancre — the initial lesion of
syphilis — is only dangerous when it is
allowed to play its part alone. Para-
doxical as it may appear, when it is
irritated and aggravated, and, as it
were, weep's tears of pus, then its
venom is gone, and it gives rise only
to a little sore, which soon passes
away.
Really, the evolution of syphilis be-
gins at the moment the germ (or what-
ever it may be) is imbibed, whether
it be through an abrasion, or through
the soft and moist and delicate tissues
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where they are generally located.
There you see it, and you can count
upon twenty-one days or more since it
was conceived. It has played its role ;
it has matured and given birth to the
tragedians, who exclaim: '*All the
world is a stage" for us.
As we approach the third act of the
drama of syphilis, memory takes me
back to the scene at Hell Gate some
years ago. For years General Newton
had, silently and almost unbeknown,
an army of laborers below the bed of
the river, working like beavers, drill-
ing through solid rock in every direc-
tion, making innumerable passage-
ways, which were filled with dynamite,
and through them all, wires were laid.
When all was ready, a child pressed a
knob connecting the electric wires, and
that mighty explosion took place, rais-
ing mountains high, acres of water,
and the terrible roar shook the earth
for miles. Then the work was over,
and Hell Gate was shorn of its hor-
rors. The explosion which takes place
in the third act of the drama of syphi-
lis is far different. Demons that have
been maturing are then let loose, and
verily! hell itself cannot be more
horrible than is this vindictive disease
to many who are in its grasp.
The first demon set free in the third
act of the drama, is one called Hypo-
chondria — a melancholy actor, who
throws the victim into a state of great
mental and physical depression.
Then the second actor, known as the
demon Anemia, puts in an appearance,
and attacks the vital fluid — feeding on
the red, disdaining the white cor-
puscles. Thus, the heart's action is
involved, the pump works less vigor-
ously and intermits and palpitates.
The oxygenation of the fluid is inter-
fered with, and consequently the vic-
tim gasps for breath, and respiration
becomes laborious.
Then appears another misanthropic
actor with sallow visage, known as the
demon Indigestion. It would be safe
to place before the victim the choicest
viands, for, like Tantalus, he cannot
tQUch them.
In women the demon Amenorrhea
appears and adds to her woes ; some-
times it gives way to one called Menor-
rhagia, but too often, during this act
of the drama, she conceives, and the
poor offspring, cursed by the sins of
its progenitors, will have all the char-
acteristics of the third act of the drama
of syphilis.
The demon Fever plays a varied role,
being often mistaken for the quotidian
type of malarial fever, with nocturnal
exacerbations.
Cephalalgia is the name of a vindict-
ive demon, who places the victim on
the rack, and, as it were, bores holes
into his brain, and makes him yell with
anguish. It will sometimes vanish
during the day, but it is sure to return
at night.
The little demon, Sternalgia, grasps
the victim by the throat and calls to its
aid — the actor. Asthma.
Vertigo makes the victim reel to and
fro like a drunken man, and makes it
appear to him as if he were a pivot,
with all sorts of fantastic objects
circling his head. This demon is gen-
erally accompanied by one called
Nausea.
Strabismus cocks the eye and gives
the victim a comical or sinister aspect.
Arthralgia loves to toy with the
larger joints, such as the shoulder, el-
bow and knee joints.
Rheumatism is booked for a long
role, but, like all actors, loves to play
at night.
Alopecia now puts in an appearance,
and if the victim has any personal
beauty, it deprives him of it. Very
often it gives him a pie-bald appear-
ance. The hair emcircling the bald spots
standing up in every direction. It also
takes away his eyebrows, giving him a
ludicrous appearance, and also a sure
sign to all the world of the nature of
the disease. Sometimes it removes
every hair from his body — from the
crown of his head to the sole of his foot.
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Third Act in the Drama of Syphilis—Robbins, 57
Demons come and go over the prom-
inent parts of the skeleton, called
Osteocopii, forming nodes sometimes
and giving rise to pains terrific.
Sometimes, and not infrequently,
the drama is tame and uninteresting,
and the third act is only ushered in by
the appearance of Erythema, whose
presence on the stage is a sure indica-
tion of constitutional syphilis.
I will now call your attention to pa-
tient's illustrative of the third act of
the drama of syphilis.
Not long ago I presented to you two
patients, which gave you a better idea
of the evolution of syphilis than you
could have attained by years of read-
ing and studying of venereal atlases.
One patient was a young pure-blooded
African. The jnitial lesion was located
on a long prepuce, just at the mucous
fold. It was of the papular variety of
Fournier, being on a sort of **raised
plateau." There were cord-like lym-
phatics extending to the bubo, and he
was covered with a papular syphiloderm
with a serpaiginous circle on his fore-
head and mucous patches in his mouth.
The other patient was a young white
man of light hair and blonde complex-
ion. The initial lesion was supposed
to be on the mucous surface of the
prepuce, which was long and edematous.
A V-shaped-piece had been cut out,
but no chancre or chancroid could be
found, but the bloody serous discharge
from the meatus .was indicative and
diagnostic of urethral chancre. As
with our other patient, there was the
**ribbon" of lymphatic vessels leading
to a bubo. This patient had a bubo
in each groin, which as in the preced-
ing case did not suppurate. From
head to foot he was covered with
roseola. With the white patient the
demons Cephalalgia and Rheumatism
were most persistent. He also had
double iritis.
Several years ago I was summoned
in the greatest haste to a man who
had suddenly fallen. A physician,
who had also been called, had pro-
nounced the case to be one of apo-
plexy. I had attended the man, how-
ever, who had chancroids that were
phagedenic, and there was a suspicious
discharge, similar to that found in
urethral chancroids. I was awaiting
the development of roseola before
placing the patient on constitutional
treatment. The man's habits were
those of a **bon-vivant," and he was
constantly under the effects of alco-
holic stimulant. Here, then, was the
stage of ''general explosion" of the
third act of the drama of syphilis that
I had to deal with. The patient be-
came maniacal, and delusions, at times
ludicrous, and pathetic at others, fol-
lowed each other. It became neces-
sary to send him to friends who re-
sided two days distant by rail. He was
placed in charge of a gentleman who,
fortunately, was a man of great phys-
ical strength, and who had been for-
merly a sailor by occupation. At night
when the train was speeding along at
forty miles an hour, the patient darted
out of the car, followed instantly by
his attendant. The patient attempted
to jump off the car, and had partially
succeeded, when he was grabbed by
the collar and dragged back, and then
began the struggle on the platform of
the rapidly moving and swaying car.
The description given by the gentle-
man who succeeded in conquering the
maniac and dragging him back into the
car was the most blood-curdling one
that I ever listened to. After this
episode, several knockdown arguments
had to bo used before they arrived at
the end of their journey. This pa-
tient gradually improved, but it was
fully three months before he was re-
stored to his customary mental equi-
librium. The history of his paramour
was very similar. She was sent to the
Hot Springs of Arkansas, the Mecca of
those who *'live not wisely, but too
well." Then she became an inmate of
a mad house, and finally death put an
end to a checkered career.
In these cases, the demons that were
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set free were aggravated by the arch
demon Drink, which, sooner or later,
brings most of its victims to the grave
or asylum.
You will remember that in a large
per cent, of cases the disease is ac-
quired in an innocent way.
ELEPHANTIASIS IN JAPAN.
By Albsbt S. ASHif bad, M. D., New York.
Note. — I recently published a com-
munication in the New York Herald^
February 8, 1903, relative to the in-
creasing occurrence of cases of ele-
phantiasis in different parts of the
United States. I pointed out the con-
nection between culex fatigans and
elephantiasis. I suggested the advis-
ability of our health authorities com-
pelling elephantiac patients to be kept
isolated under mosquito nets during
the night to prevent contamination of
our own breeds of mosquitoes, or
propagation by the imported West In-
dian breed. I sent a copy of this pub-
lication to Prof. L. O. Howard, of
Washington, and received a letter in
reply as follows :
..I
*'U. S. Dept. of Agriculture,
DIVISION OF entomology.
Washington, D. C,
February 10, 1903.
My Dear Dr. Ashmead: — I have
your letter of the 9th inst. Culex fat-
igans is known in the U. S. and has
been recorded from Massachusetts,
Maryland, District of Columbia, New
York, Illinois, Minnesota, Nebraska,
Kentucky, Texas, Virginia, New Jer-
sey, Connecticut, and is well known
in the West Indies as well as in India,
Australia, South America, East and
West Africa. I am much interested
in your newspaper article. The dis-
tribution of culex fatigans is so gen-
eral that I should think that elephan-
tiasis might spread almost anywhere
in the United States.
Yours very truly,
L. O. Howard.''
Culex fatigans is the mosquito which
is infected with the filariasic and ele-
phantiasic germ in Barbadoes, West
Indies. And from the peculiarity of
distribution of the species in the
United States, it would appear that it
has been imported to our Atlantic
coasts, and to the Mississippi and Mis-
souri rivers by way of New Orleans.
If such is the case it is reasonable to
assume that some of these importa-
tions contained the germs of filariasis
and elephantiasis of infected Barba-
does. Hence it is of utmost impor-
tance that in those states where culex
fatigans is recorded, elephantiac pa-
tients when found should be protect* d
at night from mosquitoes to prevent
continued spread of this disease.
Besides this, there is another danger
from these mosquitoes, which evidently
have been imported from Barbadoes,
as will be seen from the following let-
ter published in the Hoboken, New
Jersey, Observer^ February 16, 1903:
Danger of Leprosy From
Mosquitoes.
Sir: — In your allusion in the Ob-
server^ February 9th, to my communi-
cation on the question of elephantiasis
and mosquitoes, in the New York
Herald^ you congratulate the people
of your state on the fact that culex
fatigans, the host of the germ of this
disease, is not a native of New Jersey.
I beg to inform you that you are mis-
taken. Professor Howard, of Wash-
ington, writes me that the insect is re-
corded from New Jersey.
Allow me the further observation
that this germ, in my opinion, is the
cogener, so to speak, of the germ of
leprosy. And it is also the belief of
a good many eminent leprologists that
leprosy, too, is transmitted by some
mosquitoes of leper countries.
My own opinion for a number of
years has been that leprosy has two
intermediary hosts, which operate to-
gether: fish and mosquitoes. The mos-
quito having sucked the blood of a
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Elephantiasis in Japan— Ash mead.
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leper carries the spore ( not the bacil-
lus) to the water, where he finally
dies. His dead body, or the larvae,
are eaten by the fish, which in turn is
eaten by human beings, who in this
way may become inoculated with the
spores of leprosy. Of the spore life
of the leper bacillus, outside the hu-
man body, there is hardly anything
known. But many leprological schol-
ars are at present at work on the prob-
lem. That there is a period of spore
life to the bacillus after inoculation in
the human being is suspected because
of the long, latent period of incubation
of the disease, and because the leper
bacillus is not found in human blood.
We have no means of recognizing the
spore, which might occupy the blood
current, but our microscope and stain-
ing process tell us that the bacillus is
not there. At all events there is great
probability of leprosy also being trans-
mitted by the * 'Jersey'* mosquito if
once he should become inoculated with
the spore of the lepra bacillus.
Very sincerely yours,
Albert S. Ashmead, M. D.
New York, February 14, 1903.
1 . Some General Considerations. —
Man, indeed, being omnivorous, can of-
fer a place of habitation to the para-
sites, both of herbivorous and of car-
nivorous animals. It must be observed
that an immense majority of these
parasites is furnished to man by the
domestic animals, which is accounted
for by the frequency of our relations
with these animals, and their impor-
tance in our alimentation. Concern-
ing the manner of attack and of evolu-
tion of the parasites, the following
classification may be made: First of
all, they are naturally divided into two
large sections: internal parasites, or
endoparasites, and external parasites,
or ectoparasites. The latter are again
grouped according to the degree of
their pai'asitism. Some are free or
temporary parasites, that is,living upon
their host only when they come to
feed at his expense, and leaving him
again, or at least being susceptible of
leaving him, in order to live freely : such
are the tabanidse (gadflies), the mus-
cides (flies), the hyppoboscides, the
simuliides (biting gnats), etc., among
the insects; the dermanysses (derma-
tozoa) and the argas (ticks) among the
acarians. They attack men under the
same conditions as animals do, and,
consequently, do not deserve to be
classified as parasites. There is no
other means of avoiding them, but
keeping clear of the localities which
they prefer, or of the animals to whom
they are partial, even of the places
where these latter dwell.
The other external parasites, called
stationary, remain permanently on the
host, as soon as they have established
themselves. There are those among
them who live in freedom during a cer-
tain period of their existence, whose
parasitism is a periodical one — oestridee
(bot flies), chiques, inodes, strambidi-
ons, etc. To these the same indications
apply as the preceding; for if they
show themselves always in greater
abundance in the places frequented or
inhabited by their habitual hosts, it
happens seldom that they pass from
the animals to man.
There are also external stationary
parasites, which are subjected to the
parasitic condition from their hatching
to their death, and thus present a
permanent parasite. This is the case
with the sarcoptes scabiei, sarcoptes
minor and the demonden. With these
parasites, direct, immediate transmis-
sion predominates by far.
Regarding too the internal parasites,
the habitual mode of transmission
is mediately through aliments and
beverages. Among these are the coc-
cidae, the balantidium, divers tenias,
the distomata, the ascarides, the
stronggles, thefilaria^ thelinguatules,
etc. In most cases it is evidently
water that serves as vehicle, so that,
for the common parasites, as well as
for the microbes, the question of pot-
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able waters is of essential importance.
The distomata, however, may be in-
troduced into the human system with
vegetable aliments, when the latter are
ingested raw. Some internal para-
sites, too, are directly transmitted by
the animals themselves, with whom
man lives too intimately; the echin-
ococci transmitted by the dog, for in-
stance.
Immediate transmission also takes
place between the animal and man, in
the case of taenia solium, tasnia sagi-
nata, bothriocephalus latus, trichina
spiralis, ete. In elephantiasic or fil-
arial diseases of man the connection of
the mosquito as an intermediary host,
in the full life development of the
hematozoon, filaria sanguinis hominis
has been fully and conclusively made
out by Dr. Patrick Manson, of Amoy,
China, in the Customs Medical Re-
ports, published in Shanghai by order
of the Inspector-General of Customs.
Dr. Manson discovered the parent
filaria in the mosquito in 1878, and
has since published several admirable
articles, giving the results of his ex-
periments, which in the main were in-
dependently confirmed by Dr. Mac-
Kenzie, of the London Pathological
Society ; Lewis, of India ; Myers, Cob-
bold, Wucherer, Bancroft, Araujo
and others. These facts having an
entomological bearing and being of
great scientific interest and practical
importance, were classified by Dr.
C. V. Riley, entomologist of the U. S.
Agricultural Department, Washington.
As they were given to me in 1886 by
Prof. Riley, and as I take them briefly
from my notes which I made at that
time, they are as follows: In 18^^
Lewis announced the discovery of im-
mature or larval hematozoon in the
blood and urine of persons afflicted
with chyluria, and he named it filaria
sanguinis hominis. The mature form
was first described by Cobbold as
filaria Bancrofti in 1877. As found
in the lymph, the parent filaria emits
its young in the lymph stream. The
young makes its way from the lympb
to the blood, where it undergoes no
growth or development. In this its
newborn state it is enclosed in a deli-
cate, transparent, rather loose tunic or
cyst, and is found in the blood of pa-
tients affected with elephantiasis, but
only during the night. This disease is
manifested in a thick, tuberculated and
insensible condition of the skin akin to
leprosy. It is endemic over the more
thickly populated and tropical portions
of the globe, and in its various forms
is very painful, resulting in deformity
and not infrequently in death. The
best authorities now believe that vari-
ous diseases of the lymphatic vessels
and glands, as varicose groin glands,
lymph scrotum, elephantiasis and
chyluria are pathologically one and
the same disease, and are due to the
presence of this filaria, which has,
in fact, been recorded from South
Europe, Asia, Australia and Brazil.
Dr. Araujo has verified at Bahia its oc-
currence in the mosquito and otherwise
confirmed the observations of Manson
and others in different parts of the
world. Before the young filaria can
undergo their full development, they
must first enter the body of the female
mosquito (culex fatigans), which sucks
them up in her nocturnal attacks;
within the mosquito they develop in
from five to six days, and upon the
death of their host or before passing
into water frequented by the mosquito
for purposes of oviposition and are
thus returned by drinking to the hu-
man stomach, from which they make
their way into some lymphatic vessel,
where the sexes meeting, the female
remains perhaps for years, giving birth
to active young. Dr. Manson, in the
Customs Medical Reports, March 31,
1882, gives the results of some later
observations which are full of interest.
It seems that the periodicity in the
filarial disease has no connection, either
with temperatures, atmospheric press-
ure, or light, but must be looked upon
as an adaptation of the habits of the
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Elephantiasis in Japan—Ash mead.
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parasite to those of the mosquito.
The conditions for the ingress of the
filarise into the circulation appear to
be developed ordinarily during the last
few hours of the waking state, and
the parasites are eliminated during the
last few hours of sleep. Under ordi-
nary conditions of sleeping or waking,
the embryoes enter the circulation every
evening, increase until midnight and
diminish as morning approaches, until
they entirely disappear, and are not
found from 9 a. m. to 6 p. m. This
periodicity of the parasite is independ-
ent of parturition in the parent, as re-
production is continued during the
twenty-four hours. The importance
of thus tracing to their true source
diseases whose origin has long been
involved in mystery cannot be over-
estimated ; and these facts would seem
to give additional reasons for the
filtering of drinking water, and the
use of mosquito-nets in all tropical
climates. Dr. Manson suggested that
the facts ascertained in this connection
may lead to a possible future explana-
tion of the diurnal intermission and
remission of fevers of the ague class.
The most interesting conclusions that
have been forced upon Dr. Manson
are that the presence of the parasite
in the human body does not always or
necessarily produce disease, and that
when disease is produced, it is by ex-
ceptional oviparous reproduction, in-
stead of the ordinary viviparous mode.
His conclusions were as follows:
In the instance in which the parent
worm has been discovered, she was
found in lymphatic vessels on the dis-
tal side of the glands. This has been
shown to be in many,if not in all, cases
her normal habitat. Her progeny,
therefore, must travel along the af-
ferent vessels, through the glands,
and so on to the thoracic duct, and
thence into the blood. The lang, sin-
uous and powerful body of the em-
bryo is well adapted to perform this
journey. But suppose instead of this
mature embryo an ovum is launched
into the lymph stream prematurely,
and before the contained embryo has
sufficiently extended its chorion, then
this passive ovum must certainly be
arrested at the first lymphatic of the
lymph current. It measures 1-750"
and 1-500", whereas the outstretched
embryo is only about 1-3000" in di-
ameter. It is much too large to pass
the glands, and the embryo rolled up
in its chorional envelope cannot aid
itself. It becomes in fact an embolus.
Now, filarisB are prodigiously prolific;
myriads of young are expelled in a
very short time. Professor Riley has
watched the process of parturition in
the minute corvi torquati. Every few
seconds a peristaltic contraction, be-
ginning low down in the interior horns
and extending to the vagina, expels
some twenty or thirty embryoes. If
this process of parturition occurs pre-
maturely, or peristalsis is too vigorous
and extends to a point high up in the
uterine horns where the embryo has
not yet completely stretched its
chorional envelope, then ova are ex-
pelled. These, as they reach the
glands, where the afferent lymphatic
breaks up into fine capillary vessels,
act as emboli, and plug up the lymph
channels, one after another. In this
way the gland or glands directly con-
nected with the lymphatic in which
the aborting female is lodged are thor-
oughly obstructed. Anastomosis for
a time will aid the passage of lymph,
but the anastomosing vessels will carry
the embolic ova as well as the lymph.
The corresponding glands will then in
their turn be invaded, and so on until
the entire lymphatic system, directly
or indirectly with the vessel in which
the parent worm is lodged, becomes ob-
structed. This is the true pathology
of the elephantoid diseases: First,
parent filarise in a distal lymphatic;
second, premature expulsion of ova;
third, embolism of lymphatic glands
by ova; fourth, stasis of lymph; fifth,
regurgitation of lymph and partial
compensation by anastomosis; sixth,
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renewed or continued premature ex-
pulsion of ova; further embolism of
glands. This process, according to
the part of the lymphatic system it
occurs in, the frequency of its recur-
rence and its completeness, explains
every variety of elephantoid disease.
2. Elephantiasis in Japan, — Ele-
phantiasis in Japan is characterized as
a local disease of tropical or semi-
tropical regions. It is known to be
caused by filariasis, either chyluric or
hematic, and by obstruction of the
lymph passages. The Japanese phy-
sicians know that it existed in Egypt
since very remote times, and that it is
found to-day in the West Indies, South
America, East Indies, West Africa,
Arabia, Samoa and the Fiji Islands,
as well as in Japan and China. *'Bar-
badoes foot" it is sometimes called,
because Barbadoes, West Indies, was
the original seat of the disease. The
disease is most prevalent in Japan in
the localities where are found the most
lepers. This is in keeping with what
is known of its occurrence in other
situations. For instance, according to
Rev. Mr. Turner, a missionary in the
West Indies, fully fifty per cent, of
Ihe inhabitants of those islands suffer
from elephantiasis. There are, be-
sides, many other places where about
ten per cent, of the population are at-
tacked by it. In Japan it is leprous
Kiushiu, and especially Sai-Nan dis-
trict of Kumamoto prefecture, the
most leprous province of Japan, that
has the most elephantiasis. There
lire, according to Kitasoto's statistics,
2473 known lepers in Kumamoto.
Elephantiasis prevails in leprous Abe,
Kaseda region, Kumake district; on
Yaneko island, of Kagoshtma prov-
ince, where there are recorded 691
lepers; and in Minami, Matsubara
district of Nagasaki province, where
there are registered 769 lepers. Wher-
ever lepers are congregated there are
the most elephantiacs to be found.
Outside of Kiushiu it is also met with,
but in less numbers. For instance, in
Banta district of Doshu; in Oki island,
of Shimane prefecture, where there
are known to be 313 lepers ; in Shu-
sami village of Kishu ; in Oshiraa, of
Zushu; in Misaki, city of Soshu,
where there are 900 lepers; in Eiu-
kiu and Formosa islands — all situa-
tions scourged by leprdsy. There are
also seen more or less cases of ele-
phantiasis in other localities of Japan,
but the causes are thought to be dif-
ferent in these than, in those above
mentioned.
Elephantiasis in Japan is commonly
called '*oashi" (large foot), or **koe-
ashi'* (fat foot). In Kumamoto
province the appearance of the '*tan-
doku" (copper-colored poisoning) is
called **kusa-furu" (literally: shak-
ing of grass).
In Kagoshima prefecture, elephan-
tiasis of the lower limb is called '*shune-
buto" (leg fat), and that of the
scrotum '*ogintama" (large testicle);
and the appearance of the copper-col-
ored poisoning is called, from its sim-
ilarity, '*buku-kusa-furu" or simply
**kusa-furu" (shaking of grass).
The disease attacks more readily
peasants and fishermen who live near
the sea-shore, than the inhabitants
living further inland. Persons who
live in the interior are very liable,
while traveling through the regions
where the disease mostly prevails, to
be attacked by it. There are no
statistics ascertainable as to the exact
ratio of inhabitants attacked. But
the best authorities do not agree with
Dr. Larrey's statement, that ten per
cent, of Japanese are afllicted with
elephantiasis. Where investigations
have been made, persons suffering
with the disease were found to be
almost exclusively peasants and fisher-
men, or of poor people who were
forced to live near the sea-coast.
From information obtained from local
physicians and from other reliable
sources, more males are liable to be
attacked than females and children.
The part of the body most generally
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4ittacked is the lower limb, one or
both. Next to this in frequency is the
scrotum or penis. It rarely develops
on the upper limbs or breast, and most
rarely on face, head, fingers, or shoul-
der and arm. Sometimes it attacks
only a limited part of the skin, which
becomes pendulous, like a sack. Local
developments may appear simultane-
ously on a lower limb and the scrotum^
or on a lower limb and the breast.
When it develops on a lower limb,
scrotum or penis, considerable lym-
phatic glandular engorgement is seen.
This is usually of a hard consistency,
but sometimes a softened one presents
itself. Development of elephantiasis
on upper limbs or breast is invariably
accompanied by axillary engorge-
ment; on the face and head, by cer-
vical engorgement. The proportion
of elephantiasis development on the
lower limb, according to Japanese
statistics, is ninety-five per cent.
The symptoms of elephantiasis in
-Japan are similar to those of the trop-
ics. It begins with chilliness or shiv-
ering, followed by fever. The parts
affected are markedly red and swollen,
and the neighboring lymphatics show
inflammatory dilatation. The fever
subsides in two or three days, leaving
on the skin an inflammation which,
during the subsidence of the fever,
vanishes more or less, but not entirely.
The fever repeats itself three or four
times a month, but usually the returns
occur three or four times a year. As
the fever is repeated the affected parts
increase in inflammation, and the
lower limbs gradually **get fat,'* as
the Japanese call it, thus showing a
hard, «*elephant-foot-like" tumor.
The scrotum increases in bulk, reach-
ing to several <'tens of pounds'* in
weight, and not infrequently to such
an extent that its lower portion touches
the ground. Violent exercise or in-
jury of the affected parts brings back
the fever. The skin of the affected
parts sometimes appear smooth, at
other times rough, or milky looking
inflammation. In general, it is of hard
consistence. But on the scrotum it is
usually soft, which is due, perhaps, to
the fact that here the elephantiasic
process occurs by lines and roots in a
portion already pendulous. The scro-
tum development is frequently accom-
panied by hydrocele. This was noted
by one doctor three times out of forty-
three cases. The secretion of water
did not differ from ordinary hydrocele,
and microscopic examination of the
contents revealed no filarial germ. The
elephantiasic portions in these cases
did not present the tense sensation, or
feeling of pressure, nor the character-
istic ''fattening." In one patient, an
old woman, who had already ''fatten-
ing" apparent of the labia and lower
limb, on closer examination showed that
the growth had not developed on one
side of the leg as much as on the other.
The cause of this was found to be that
she had habitually sat in the Japanese
fashion, squarely and closely, so that
the inner sides of the limbs had pre-
vented the growth, while the outside
alone showed characteristic "fatten-
ing."
Elephantiasis in Japan is not caused,
in the opinion of Japanese physicians,
by an obstacle to the lymph pass-
age. But it is thought that it is proba-
ble that the copper poisoning-like in-
flammation of elephantiasis is due to
the development of elephantiasis in the
obstructed passage of the gland, where
the lymph accumulates.
The cases of chyluric disease in con-
nection with elephantiasis in Japan are
very rare. Only one such case was
met with in forty-three elephanti-
acs, and in not one case was the filarial
germ found in the blood of patients
suffering with pure elephantiasis. The
duration of the disease in acute cases
consumes several decades, but death
directly from the disease hardly ever
occurs.
3. The Connection Between Filaria-
sis and Elephantiasis. — The cause of
chyluria, the usual effect of filariasis.
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Original Articles,
was discovered by Deraarquay in 186&,
by a scrotum inflamed and filled with
water of chyluric character. It was
the filarial germ. This germ was first
seen by Wuchurer, in Bahia, Brazil,
in 186G, in the urine excreted by a
chyluric patient. Subsequently, in
1870, it was found by Lewis, of Cal-
cutta, India, in the lymphatic glandd
of an elephantiasic patient afilicted in
the foot and scrotum, and also in the
blood of a hemato-chyluric patient. In
1872 Lewis thought that the usual
abode of this germ was in the blood,
and gave it the name of fiiaria san-
guinis hominis. Subsequently Patrick
Mansonmadean investigation on fiiaria
Bancrofti, the mother germ, and con-
cluded that its abode was in the lym-
phatic vessels. Further, he explained
that the medial host of this germ was
the male mosquito, which sucks the
blood infected with the germ, and then,
in six or seven days, causes metamor-
phosis, resulting in a body one-six-
teenth inch long. If we suppose that
the human blood filariasic germ, like
other parasitic organisms, requires a
medial abode, it is to be inferred that
the disease was contracted by man
through drinking or bathing in water
which conveys the germ developed in
the body of the mosquito or louse; or
it might be that the germ escapes with
the excretions of the patient, soaks in
the ground, and then, in the presence
of moisture or water, effected a cer-
tain metamorphosis and finally entered
the human body through some medium.
In Japan the urine of every place is
saved, collected in barrels and allowed
to stagnate, decompose, for the pur-
pose of manuring rice fields. Nothing
in Japan is thought to be so valuable
as a manure as rotten urine. It could
very well become the source of con-
tagion or intermediary transmitter of
a host of diseases. And in the case of
chyluria is probably a frequent means
of infecting other insects than the
mosquito with the germ of elephan-
tiasis.
Later Patrick Manson reported that
the blood germ of filariasis, whick
took up its abode in human blood, wfis-
not the only kind to which Lewis had
given a name, but that there were sev-
eral kinds, four or five, and probably
more. Thereupon, he gave the new
name fiiaria nocturna to what had been
known before as the filariasic germ»
To the other five kinds of germs he
gave the names fiiaria diurna, fiiaria.
perstans, fiiaria Demarquaii, fiiaria Oz-
zardi and fiiaria Magalhaes.
Fiiaria nocturna, as is well known,
appears, according to the condition of
the host's body, in the arterial blood
vessels only during the night. Fiiaria
diurna exists in Western Africa, and
appears in the blood vessels during^
the day and vanishes in the night.
These two germs are almost of the^
same size, and are similar to each
other,
Fiiaria perstans exists to a large ex-^
tent in Western Africa, and has no
covering membrane. Its size is about
one-half of that of the former two,
and appears in the blood current dur-
ing both night and day.
Fiiaria Demarquaii is found in the
West Indies and New Guinea, and is
almost the same size as that of fiiaria
perstans. Its posterior part, however,
ends in a sharp point, giving a tail-like
appendage, and appears to be destitute
of covering membrane. This germ
appears also in the blood during both
day and night.
Fiiaria Ozzardi was discovered in the
blood of natives of British Guiana,
South America, and is nearly the same
size as that of the last two. It has
no covering membrane, and exists^
in the blood vessels during both day
and night. This germ is of two kinds,
the one sharp-tailed, the other blunt-
tailed. Whether these two kinds may
be considered as belonging to the same
species or not, is a question.
Again, the opinion that the sharp-
tailed one is the Demarquaii germ, and
that the blunt-tailed one, f . perstans^
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is not yet ascertained. The other
opinions, that filaria Magalhaesi is
the germ having sexual distinction,
discovered by the Rio Janeirian Ma-
galhaes in the left ventricle of the heart
of a dead child, and that it is wholly
distinct from Bancroft's filaria; and
that, since its discovery in human blood
of the western hemisphere, filaria De-
marquaii is the grown germ of filaria
Ozzardi, have not been proved.
Of all the germs above mentioned
filaria nocturna is the one most ex-
tensively found. Its probable mother
germ, or Bancroft's filaria, was dis-
covered for the first time in the sub-
dermic layer of the armpit. After-
wards it was found by Lewis in
coagulated blood of an elephantiac
patient who had the characteristic
dilatation of the lyniphatic vessels.
Its length is about 38 mm. and thick-
ness that of a hair. C. W. Daniels
ascribes the diflSculty of distinguishing
the grown germ to the uncertainty of
its abode, the minuteness of its size
and similarity of its appearance to that
of the oth,er germ. Mansop holds the
opinion that although the grown germ
may exist in the blood, it does not
invariably produce the disease. This
seems to be true from the fact that
when he examined the blood of eighty-
eight healthy natives of Cochin China,
for Surgeon Elcum, he found twenty
specimens out of seventy-four of
healthy blood to be infected with filaria
nocturna. The other fourteen speci-
mens of blood were found to be those
of elephantiacs, and in these there was
only one that was free of the germ,
from which he inferred that the pres-
ence of filaria in the blood was not
always proof of filariasis, nor absence of
it freedom from the disease. However,
it may be explained by supposing that
the filariasis is caused by obstruction
to the lymphatic passage and grown
germs often die without leaving off-
spring.
In Japan the diseases which are
classed as filariasis are, inflammation of
lymphatic glands, tumor of glands,
tumor of armpit, lymph scrotum, dila-
tation of dermic and subdermic lymph-
atic vessels, hydrocele, chyluria, dis-
charge of chyle by the bowels, and
hemato-chyluria.
Local elephantiasis, in accordance
with the views of Magalhaes,Wucherer
and Manson, is also called filariasis.
Turner's view, that elephantiasis is
caused by the malarial germ, is not be-
lieved in. The reason that Manson
classed elephantiasis as filariasis is not
only that the grown germ is found in
the blood of elephantiacs, but because:
1. Filarial infected localities are also
infected by elephantiasis; wherever
there are most filariacs, there are found
also the most elephantiacs. 2. The
dilatation of lymphatic vessels, char-
acterizing filariasis, is also seen in
elephantiasis, and frequently appear
simultaneously . 3 . Lymph-scrotum ,
undoubtedly filariasic, is often accom-
panied by scrotal elephantiasis. 4. Bar-
badoes leg sometimes follows an oper-
ation on lymph-scrotum. 5. Elephan-
tiasis and dilatation of lymph-vessels
both belong to disease of the same
system, the lymphatics. 6. Character-
istic filariasis, dilatation of lymphatic
vessels and true elephantiasis both
show symptoms that accompany the
repeated occurrence of inflammation of
lymphatic vessels. 7. The cause of
the characteristic dilatation of lymph-
atic vessels of filariasis has been traced
to the filarial germ, and elephantiasis
often simultaneously appears with it
and must have a close connection with
that germ. Hence it is fit to ascribe
the same cause for both diseases.
Manson gave as reason for not find-
ing filaria in the blood of a majority of
elephantiacs, that the lymphatic vessels
which convey lymph from the affected
part of the' body were obstructed.
Thus further infection was prevented.
It has since been shown that the imma-
ture germ produced the obstruction.
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Original Articles
Dr. Honda, of Japan, believes that both
the mature mother germ and the ova
play a part in the obstruction.
The cause of elephantiasis in Japan,
as in other tropical countries, is be-
lieved to be filariasis. But some phy-
sicians doubt that the local elephan-
tiasis is characteristic of that disease.
There are several opinions held in
Japan as to the cause of this type of
elephantiasis, such as heredity, syph-
ilis, the independent germ theory and
filaria. But none was proved nor was
it ascertained by examination of the
affected skin, or by the discovery of
filaria in the lymphatic vessels. Thus
far, discoveries worthy to be referred
to have been made by Doctor Otani,
of the Nagasaki Hospital, who found
filaria in the biood of two patients,
one of whom was affected simulta-
neously by elephantiasis and filariasis
of the scrotum, the other by elephan-
tiasis alone. Another case of reference
relates to investigations made by Doc-
tor Wayuchi on three patients who had
both diseases simultaneously on Oki
Island.
The hereditary theory as the cause
of the disease is based on the fact that
members of the same family are par-
ticularly liable to contract the disease,
which indicated to the Japanese that
the primary cause might be trans-
mitted and received by blood relation.
They did not take into account the
probability of local mosquitoes becom-
ing affected by the sick member of the
family and the community afterwards
through drinking water.
Moncorvo, of Rio Janeiro, has re-
ported three cases of congenital ele-
phantiasis. Scheube expressed doubt
as to the possibility of congenital
transmission of filaria characterizing
elephantiasis. Doctor Honda exam-
ined some cases but saw nothing that
would indicate the possibility of hered-
itary transmission of the disease. Nor
did he meet with an instance of one
member of the family affected after
the other. In Japan, however, there
are on record two cases where mar-
riage of daughters of elephantiac
parents had been followed by develop-
ment of the disease. But this is not
thought to be due, necessarily, to he-
redity, for it is well known that trav-
elers who pass through infected local-
ities are contaminated with the dis-
ease. The theory of syphilis as a
cause of elephantiasis is dismissed
from the medical mind of Japan,
without argument. Its support is of
the weakest kind. The germ theory
as a cause is said to have been held by
the late Doctor Yashuo.
In an article, * 'Investigation of Fila-
riasis,'* by Doctor Jamura, of Japan,
who studied elephantiasis in Kiushiu,
he describes its cause as filariasis.
But, generally, the opinion is held that
the exact nature of elephantiasis there
is yet unknown.
Dr. Honda, of the Japanese navy,
has investigated elephantiasis along
the sea-coasts of his country in many
localities. He studied first filariasis,
to fiod out the relationship between
it and elephantiasis. In Amakusa
island, he had twenty doubtful cases,
of which sixteen proved subsequently
to be elephantiasis. In Kagoshima
prefecture, he had twenty-seven cases,
in all forty-three cases. Among them
about four-fifths were over forty years
of age. He explained this fact by the
plea, that the young men and women,
from fear of exposure of their infirm-
ity, would not come to his dispensary
where they might meet strangers.
Hence age could not be taken into ac-
count in his investigation. Of these
forty-three patients, there were thirty
men and thirteen women. Their oc-
cupation was peasants, next in frequen-
cy fisherman, and only one merchant.
Three of them had scrotal elephantia-
sis. The character of the fluid of the
scrotum did not differ from that of
ordinary hydrocele. Microscopic ex-
amination showed no filaria in the
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Elephantiasis in Japan—Ash mead;
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water. Twelve cases were without
pain from the engorgement. The con-
sistency was very hard.
For the pm'pose of determining a
relationship between elephantiasis and
filar iasis, he "studied especially the
disease which most surely is manifested
in filariasis, that is chyluria. In the
warm region of Kmshiu coasts, both
elephantiasis and chyluria show them-
selves predominant, which he thought
confirmed Manson's opinion, that the
two diseases are locally connected.
But later observations dispelled this
notion. For according to the physi-
cians of Amakusa island (Kiushiu)
one disease is almost exclusively con-
fined to the upper part of the island,
while the other one is found most
abundantly in the lower part. Dr.
Honda found several cases of filariasis
in the lower part of the island, but
scarcely any elephantiacs in that same
spot. In other places there were many
elephantiacs but not one of filariasis.
He found out also that chyluria af-
fected both wealthy and poor people,
while elephantiasis, mostly the latter.
He could not understand this, if both
diseases had the same cause. In
Kagoshima there were several towns
where twenty or thirty elephantiacs
were produced, but the local physicians
said there was no case of filariasis.
This he thought was due to the fact
that poor people who are mostly af-
fected by filariasis could not afford to
employ physicians, and because it did
not appear to their minds as serious an
affection as elephantiasis ; thus it was
hidden from the doctors. He does
not deny, therefore, the simultaneous
manifestation of the two diseases, un-
til he has observed it by permanent
residence there. He spent four days
there and saw the filarial germ in only
one case out of sixteen. This was a
patient with both diseases. In an-
other case he could obtain no lymph,
because the affected parts were so hard
that no knife or pin could be inserted.
In Kaseda, Kagoshima, he found no
filaria in the blood of twenty-seven
cases examined. If, therefore, he
says the cause of elephantiasis in Japan
is due to the filaria, it is strange that
no one has found the gerpi in a pa-
tient's blood. He thought that he
might detect the germ by examining
the blood and other contents of the
affected parts during the period of
* 'copper poisoning" rash, so he made
a microscopical preparation of the
blood from the foot of a woman twen-
ty-two years old, who was in the last
period of kusa-f uru (sha^Ling of grass) .
The result was negative. But he did
not take the blood, after repose, or
while she was sleeping.
Case 1, — A native of Fukami vil-
lage ; age, sixty-eight ; occupation, fish-
erman. Diagnosis, elephantiasis of both
lower limbs and simultaneous chyluria.
Healthy since birth, no remarkable dis-
ease. At the age of thirty-five at-
tacked by '«kusa-furu." At the be-
ginning the appearance recurred five
or six times a year, but at present
only once or twice a year. For sev-
eral years he suffered from '*gonor-
rhoea," excreting whitish, or reddish
white, turbid urine, and not infre-
quently he felt pain from obstruction
to the passage of urine. This gradu-
ally subsided, but not entirely. Ex-
amination of the blood showed filaria.
Case 2. — A native of Otari village;
occupation, peasant; age forty-five.
Diagnosis, lower limb elephantiasis.
He was healthy from birth, but waer
attacked by "kusa-furu" when thirty-
four years old. At every appearance
of this fever and rash the **fattening"
of the lower limbs was increased ; the
lymphatic vessels may be seen to be
inflamed and much dilated. From one
of the affected parts, where the skin
was soft and undulating, a drop of
fluid was withdrawn and examined. A
worm very similar in shape and struct-
ure to filaria nocturna was found.
The movement of this worm was slow,
due, perhaps, to the low temperature,.
40 degrees F.
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Original Articles.
--v5^J
JR a E B'
^
»^ A
•fe 5Ji * ^^
^
^ Jfe -'^
/" «: ^ T
4
9 * m
^>«J*M
*R ^ T
«t 3 Bm
msLm
A ;' «^
^m%
^ Si 1^
^ U Si
A. Germ taken from a dilated lymphatic vessel of lower
limb elephantiasis. B. Germ taken from soft part
of inflamed lymphatic gland.
H Case 3, — A native of Otari village;
occupation, peasant; age, forty-three.
Diagnosis, lower limb elephantiasis.
Since five years of age has been af-
flicted with elephantiasis. As the ap-
pearances of fever repeated themselves
the lower limb increased in bulk; the
lymphatic vessels were also seen to di-
late and inflame. In the beginning
the outbreaks of fever were frequent,
but now only twice or thrice a year.
When it now occurs it lasts only three
to six days. The upper part of lower
limb is generally hardened and stiff.
Its front part has two soft, elastic de-
velopments on it of the size of the tip
of the small finger. The skin of these
two portions appears as a very thin
layer, showing the contents beneath
it. A pin prick is not followed by a
flow of blood. Instead, a transparent,
thick liquid oozes out of the hole.
Microscopic examination revealed a kind
of thread worms, whose movements
were slow. Their size was larger than
filaria nocturna's, and apparently
measured 1.25 mm., with covering
membrane very rare. Both extremi-
ties were of the same size. One ex-
tremity, which appeared to be the
head, if it had been slightly broader,
had two or three elevated rings, which
might be due to its death.
Case 4. --A native of Akangi vil-
lage ; occupation, peasant ; age, twenty-
two. Diagnosis, lower limb elephan-
tiasis. There was no inflammation of
lymphatic vessels in this case. She
had been healthy since birth, but had
not yet menstruated. At the age of
sixteen was affected with '*ku8a-furu."
They recurred four or five times a
year, each time continuing three days.
Her last attack of it was ten days ago.
The right lower limb, upper part, is
''fattened" more than usual. Near the
ankle joint there are several slits at the
side, from which oozes a transparent
liquid. Examination of this gave neg-
ative results. There was no worm. A
sofl line ran obliquely over the inner
side of limb. An aspiration needle
was inserted deeply here and a small
quantity of fluid drawn out. Examina-
tion of this showed worms identical
with those of case 3.
Case 5. — A native of Otari village ;
a peasant woman ; age, fifty-five. Diag-
nosis, lower limb elephantiasis. Healthy
from birth ; since eight years ago is
affected with **kusa-furu," which re-
peats itself once or twice a year. Grad-
ually both limbs increased in bulk. In
late years the appearance of "kusa-
furu" is accompanied by red inflam-
matory development on the affected
parts. Before the subsidence of the
rash, violent exercise always prolongs
its period, The aspirating needle drew
from a soft part a sanguineous fluid,
which on examination revealed thread
worms, like in cases 3 and 4. They
were very small, and net so plentiful;
a microscopic slide showed only one or
two.
In these five cases there was only
one of simultaneous occurrence of ele-
phantiasis and filariasis. Yet this one
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•case is sufficient to confirm the belief
that they are the same diseases in Ja-
pan as well as elsewhere. The filaria
obtained in the second case proves
this, and it is probable that the worms
of the third, fourth and fifth cases
were metamorphoses of filaria noc-
turna, occurring m the lymphatics.
Dr.Iyijima thought these thread worms
differed anatomically from Lewis' fila-
ria, as it occurs in the blood, and that
the difference might be due to their
lymphatic habitat. Dr. Honda classi-
fied his worm as a distinct kind. Ac-
cording to Mueller, there are two hun-
dred and twelve different kinds of
filaria.
Here are Manson's germs:
Pig. 3ft.— («) Filaria nocturna X 300;
(h) t dinnia, Africa X 300 ; ,(c) f.
Deuiarquaii, St. Vincent X 300; (d)
f. Ozzardi. British Guiana X 3X)-, (<r)
f. perstans. Airic:i X 3j{).
Dr. Honda's conclusions on his in-
vestigation of the subject in Japan,
which he made to his government, are
that Manson's view that elephantiasis
and filariasis are locally connected is
not proved by Japanese facts. Yet he
admits that his view has been geograph-
ically too narrow, and that it is pos-
sible in a broader locality; regions
where elephantiasis prevails ma^ also
be always the regions where filariasis
prevails. He thinks that when eJapa-
nese physicians have said that they have
not seen filariasic cases, but only ele-
phantiasis, it is because they were not
able to distinguish between them.
Conclusions may be drawn as follows:
1. Elephantiasis is endemic in Kiu-
shiu and other parts of Japan and is
identical in its symptoms with that of
other tropical regions of the world.
2. Simultaneous manifestations of
elephantiasis and filariasis are identified
with Amakusa and Kagoshima.
3. Elephantiasis affects principally
poor people, especially peasants and
fishermen living near coasts.
4. Elephantiasis and chyluria occur
together, biit rarely.
5. The existence of the Lewis filaria
in the blood of pure elephantiacs is
very rare. Elephantiasis, when accom-
panied with chyluria, shows filaria in
the blood. Hence, in Japan, too,
elephantiasis is traceable to filariasis,
and the disease therefore belongs to
the filarial diseases.
6. Thread worms, although differing
from the filaria of Lewis, must be rec-
ognized as connections with the cause
of elephantiasis. The thread worms of
Japan, even if they are distinct worms
from those of Lewis, are filariasic
worms; therefore Japan's elephan-
tiasis must be regarded as filariasis.
Filariasis is not caused by one and the
same worm in different parts of the
world, any more than they are carried
everywhere by the same breed of mos-
quito.
7. The difficulty of finding filaria in
the blood of elephantiacs in Japan may
be attributed to the fact that the
lymphatics are obstructed and to the
Japanese system of hot baths. The
habitat in the human body may be dif-
ferent there. It may be also due to
the fault of the Japanese physician's
technique.
8. The germ of elephantiasis and
filariasis gets into the Japanese human
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J
Health of Women— Elsner.
73
proper clothing. From the age of
live to thirteen you find our little girls
attending public schools, where their
little minds are crowded beyond their
capacity and at the expense of phys-
ical development. If physical culture
is practiced, it is too meager and
almost entirely misdirected. It is in
these schools where we allow children
to needlessly contract disease, and
often carry with them through life
some effect of its ravages. The poorer
classes must, after going to their
homes, look after a younger member
of the family or do housework, so
that the entire waking hours are given
up to toil. Among the well-to-do no
better conditions exist. It is French,
German, music teacher or dressmaker
that requires their time.
At the age of puberty we find our
girls divided; the one class continue
with their mental work at high school,
the others are sent into the world to
make their own way. During this
stage of development we meet with
the most prolific causes for future
trouble. No attention is paid to the
change in the girl's nature — her nerv-
ous tension as she approaches her first
menstruation. Instead of being kept
quiet in mind and body, she is hustled
with recitations and study periods on
the one hand, with hard work in
poorly ventilated shops or stores on
the other. With acutely congested
pelvic orgfans she starts her period,
and for lack of advice she continues
and soon builds the nidus for an ever-
lasting defect of some sort. Chloro-
sis, gastric disturbances, constipation,
hysteria as well as organic nervous
troubles appear. Menorrhagia, metror-
rhagia, dysmenorrhoea and amenor-
rhoea, together with altered position of
the pelvic organs, now abound. She
is making a most excellent start to
ripen into ''womanhood of the age."
After school days are over the
young woman is face to face with the
social problem. The one class does
society, and the other is done by so-
ciety after a hard day's work in shop
or store. Why is it that todaj' a good
house servant is a treasure? Simply
because the girl refuses to put up with
a healthful home, good food and moral
restraint, and prefers short hours with
cold meals and bad ventilation, in
order that at six at night, and every
night, she is free to dance, to skate,
and indulge (if she chooses) in all
forms of improper social relations. It
is often said ''appendicitis was not
heard of years ago." True. It ex-
isted, but was not diagnosed. How-
ever, pus tubes, ovarian and uterine
diseases were not common in our
grandmothers. It is not physical de-
generation that underlies all these
troubles, but immorality, and mostly
among the men, that should be looked
to for the causes of these unhealthy
states in women. I tell you, gentle-
men, small-pox is not in it when, in
one week's experience of a general
practitioner, he sees a child of five, a
mother of fifty, seven males with
gonoiThcea and two fresh cases of
syphilis, one of them with the initial
lesion on the tonsil. What hope is
there for the future generation ?
As for the married woman of today.
Well, her aim is to lead society, avoid
conception and, if unsuccessful, at-
tempts to relieve herself or gets the
abortionist to assist her. If she bears
children she most often refuses to
nurse them, and only when it is too late
does she see her mistakes.
Diseases and conditions due directly
to occupation, such as lead, mercury
and arsenical poisoning, writers' cramp,
house-maids' knee and many others do
not interest us just here. We are only
concerned in the work that produces
pelvic and genital congestions, as we
get in the tailoress, seamstress, clerk,
cook, etc., when their physical and
moral education has failed to prepare
the body to endure these hardships
with immunity. How different is the
picture of the girl you meet with
bright, sparkling eyes, full, ruddy
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74
Original Articles
cheeks and a graceful, elastic gait.
Such have profited by good physical
and moral training; you can send her
behind a desk or counter with plenty
of endurance to meet all demands of
her work; even then she is not too
fatigued to enjoy a dancing or a theater
party. She has a clear, cheerful spirit
because she enjoys perfect health. She
is the woman who fills the house with
contentment and happiness. She is
never wearisome or fretful and makes
the ideal mother.
It is self-evident from some of the
foregoing statements what should be
done to remedy this great evil. I prefer,
however, to incorporate anything fur-
ther that may suggest itself to eliviate
the distress to my summing up.
In the first place we, as physicians,
must make a bold stand to inculcate in
the young as well as the old, the rich or
poor, such habits of life that will form
the basis for physical and moral
strength. We should discourage mar-
riage for those that are unfit physically,
mentally or morally.
We must insist on fresh air in and
out of the homes; protect against any-
thing that breathes the air of nervous-
ness to the child, see to it that the
ignorant mother be instructed how to
bathe, dress and care for her infant.
Mothers should be shown the advantage
of making companions and comrades
of their young daughters so that at the
time of their growing into womanhood
all matters therewith connected can be
freely discussed.
Plead with our educational boards
not to crowd our children ; and create
in school life a demand for a competent
physical trainer. Encourage public
games and parks where children should
be compeljed to attend after school
hours. Start public school inspection
even if we must volunteer our services.
Seek legislation to control by medical
inspection shopworks and so reject such
as are unfit for certain work and desig-
nate such labor as may suit their work*
ing capacity. Such inspectors should
have the power to make suggestions
for better light and ventilation of shops
and stores. It should be made a mis-
demeanor for a girl under eighteen
years of age to attend a dance and like
places of amusement at night unless
accompanied by a guardian or parent.
Preach and preach to the young mar-
ried woman about her duty to the world
and her offspring. Show her the beauty
of a good home with children that will
be an everlasting monument of health,
happiness and prosperity.
SPINAL ANESTHESIA WITH TROPA-CO-
CAISE IN QENITO'URINARV
SURQERV.''
Bt M. Kbotoszyneb, M. D., San Francisco.
As early as 1885 in the first publi-
cation upon spinal anesthesia that ap-
peared in medical literature. Corning
(1) says: "Whether the method will
ever fijad an application as a substitute
for etherization in genito-urinary or
other branches of surgery, further ex-
perience alone can show." Since
August Bier's first experiment with
spinal anesthesia he emphasized the fact
that operations in the pelvis, perineum,
and the anus are fitted for this mode
of anesthetizing, as complete analgesia
may be obtained for these regions
through small and comparatively un-
dangerous doses of the anesthetizing
drugs.
My own experience with spinal an-
esthesia dates back about two years.
At that time I witnessed several oper-
ations under spinal anesthesia by Dr.
Tait, who, with Dr. Caglieri, wrote a
remarkable treatise (2) upon the sub-
ject. I soon afterwards proceeded to
experiment with spinal cocainization
in some of my old prostatic patients,
where a general anesthetic appeared to
be dangerous on account of heart and
kidney complications. My experience
with the method was not very satis-
factory on account of the very dis-
•Read before the Medical Society of the State of CaU-
fomia.
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GenitO' Urinary Surcery—Krotoszyner
76
tressing and often dangerous symp-
toms which most of my patients ex-
hibited daring and after spinal cocaini-
zation, and at the last meeting of the
California State Medical Society, held
in Sacramento, I said, discussing Dr.
A. W. Morton's (3) paper on spinal
cocainization: "I have used this
method . . . and have noticed such
violent and distressing symptoms . . .
that I would not wish to repeat this
method of anesthetizing unless I am
compelled to."
Such and similar objections to spinal
cocainization are voiced by various au-
thors. Mikulicz (4) for instance, re-
ports among thirty-five cases of spinal
cocainization, ten times distressing
symptoms during and eight times after
the operation. The horrible picture
of intoxication so often observed after
spinal cocainization is best described
by Kam merer:
''Suddenly the patient becomes pale,
the pulse becomes rapid and small ; the
patient yawns and makes deep and
difficult inspirations until dyspnea sets
in, pulse thready, not palpable; profuse
perspiration, nausea and vomiting,
spastic contractures of lower extremi-
ties; pulse-rate, that had increased to
140-160, sinks to 55-70; collapse at
different periods. These symptoms
may last a very few or even fifteen or
twenty minutes."
I had, therefore, almost decided to
abandon spinal anesthesia entirely
when my attention was shortly after-
wards called to an article of Willy
Meyer of New York (6) who had op-
erated on three cases under spinal an-
esthesia with tropa-cocaine, and at the
same time Schwartz's (7) publication
upon the use of tropa-cocaine in place
of cocaine fell into my hands. Schwartz
arrived, through carefully conducted
experiments, at the result that 0.05
tropa-cocaine injected into the sub-
arachnoid space produced as perfect an
analgesia as the ordinary cocaine,
while none of the disagreeable and
dangerous symptoms experienced with
the ordinary cocaine w«re noticeable.
Tait (e. c), who had experimented
with several other drugs in order to
avoid the toxic influence of cocaine,
began at the same time to use the
tropa-cocaine and called my attention
to its advantages over the cocaine, es-
pecially in its not being accompanied
and followed by the above-mentioned
distressing and dangerous symptoms.
I had at that time under my care an
extremely sensitive patient of seventy-
five years, with a supra-pubic fistula of
four years' standing as a result of su-
pra-pubic lithotomy, from which the
urine continually flowed down along-
side the supra-pubic tube over the pa-
tient's thighs, causing a very annoying
eczema. Rectal examination revealed
a very large prostate, the middle lobe
of which obstructed the entrance of
the bladder. On account of the pa-
tient's advanced age and his faulty
kidneys, an operation under local an-
esthesia in the hypersensitive patient
seemed to be impracticable. I there-
fore decided to perform a Bottini op-
eration under spinal anesthesia with
tropa-cocaine. I injected 0.05 or 5-«»
of a grain of tropa-cocaine and start-
ed five minutes after injecting to
operate. In rapid succession I intro-
duced steel sounds of increasing size
in order to dilate the urethra, that had
not been used for several years as a
urinary channel; then I introduced the
Bottini instrument and made three very
extensive incisions to the three lobes
respectively, leaving a catheter in the
bladder afterwards. During the opera-
tion the patient was occupied in conver-
sation with a friend, his pulse did not
increase in rate nor deteriorate in vol-
ume, no nausea, no vomiting, respira-
tion normal, not the least sign of pain
during cauterization of the gland.
The patient did not show any disa-
greeable after-effects from the anes-
thesia (no rise in temperature, no
headache). I repeated in this patient
twice the same same method of anes-
thesia, the first time about six weeks
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76
Original Articles,
after the first Bottini operation, in or-
der to close the supra-pubic fistula, the
second time, two months after the
second operation, in order to perform
a second Bottini operation for the re-
establishraent of the spontaneous
micturition through the natural pas-
sages after closure of the supra-pubic
fistula.
Such a result could never have been
obtained without the aid of this method
of anesthetizing, because I don't think
the patient could have survived three
general narcoses, neither would a care-
ful surgeon have attempted these op-
erative procedures on account of the
dangers connected with general anes-..
thesia in old and decrepit individuals.
Since this experience I have done
almost all my genito-urinary surgery
under spinal anesthesia with tropa-
cocaine and can recommend it highly.
I have operated so far in over one
hundred and twenty cases. Most of
my work was done on the bladder,
scrotum, penis, etc.
Tropa-cocaine is chemically benzol-
pseudotropin hydrochlorate, and has
the formula C« H,, No (C« H,-CO)
HCL. This alkaloid occurs with co-
caine and other bases in the small Java
Coca leaves, prepared synthetically by
Liebermann. It forms white needles,
melting at 271 degrees C, or 519.8
degrees F., and is readily soluble in
HjO. In solutions of 2 per cent, to 5
per cent, it produces a rapid anes-
thesia, is less toxic and more reliable
than cocaine (Ferdinando and Chad-
bourne).
I have always used for my work the
glass tubes as prepared by Dr. Tait.
Each tube contains 1 cc. of a 4 per
cent, solution of tropa-cocaine, both
ends of the tube are sealed, then
placed in a bath of water and glycer-
ine for one an<l one-quarter hours at
a temperature of 120 degrees F. and
cooled off. The glass is filed off at a
convenient place so that it may be
broken when the contents are needed
for injection. I shall not describe here
the instrumentarium and technique of
lumbar puncture, as those points are
repeatedly dwelt upon by various au-
thors in former publications. I gen-
erally obtained complete analgesia for
my field of operation by the above-
mentioned dose of tropa-cocaine, and
generally started the operation ten
minutes after the injection. In some
cases where I injected less than 1 cc.
of the 4 per cent, solution, or even
only half the dose, I had to wait fif-
teen, twenty or twenty-five minutes
until analgesia was obtained. In two
cases of my whole material no anal-
gesia occurred, and the operation had
to be done under general anesthesia.
In both instances the escaping of sev-
eral drops of cerebro-spinal fluid made
it sure that the point of the needle had
punctured the subarachnoid space, and
in the case of a very nervous woman
with vesical spasms certain symptoms
(slight icterus with rise of tempera-
ture until eight days after spinal
puncture) were observed that I was
inclined to ascribe to the lumbar
puncture.
In nervous and excitable patients,
occasionally, the operation was some-
what impeded by great restlessness of
the patient, which sometimes could be
arrested by placing a mask over the
patient's face, simulating chloroform
anesthesia. Whenever those patients,
after the operation, were asked if they
had felt any pain they invariably de-
nied it. We never used of late a
stimulant hypodermatically or per
OS before or during the operation,
as generally no shock or other dis-
tressing symptom caused by the punc-
ture or the injected drug were notice-
able. One assistant is placed at the
head of the patient to carefully watch
respiration, pulse, pupils, etc. A
nurse is detailed in some instances to
engage a nervous patient in pleasant
conversation and to distract notes upon
one interesting observation.
An important point that so far has
not been brought out is that this
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Genito- Urinary Surgery—Krotoszyner.
77
method of anesthesia permits us to ob-
tain the patient's consent for removal
of an organ daring the operation,
where in general anesthesia a second
operation would be necessary because
the patient's consent for a more radi-
cal procedure could not be obtained.
To illustrate this point I may be per-
mitted to give brief notes upon one in-
teresting observation.
A man of thirty-three consulted me
for a subacute anterior urethritis ( with
gonococci) and epididymitis on the
right side. Upon taking the history
of the case I ascertained that the right
testicle had been swollen for several
months previous to the present attack
of gonorrhea, which at that time lasted
for about three weeks. As no benefit
could be effected by ambulatory treat-
ment, the patient was persuaded to
enter the hospital, where, in spite of
rest and careful treatment, the swell-
ing of the right epididymis increased ;
a few. days later an effusion into the
tunica was noticeable, which rapidly
increased ; puncture was made for di-
agnostic purposes and 1 cc. of a sero-
purulent fluid obtained, that contained
pus cells, tubercle bacilli, streptococci,
but no gonococci. The operation un-
der spinal anesthesia revealed an epi-
didymis and testicle that were entirely
riddled by tubercular abscesses, miliary
tubercles covered the cord and sur-
rounding tissues up to 4 or 5 cm. from
the epididymis. I informed the pa-
tient of the condition of the organs
mentioned, and obtained permission
for castration, which I did, following
up the vas deferens to the internal in-
guinal ring.
I am certain from my experience
that spinal anesthesia with tropa-co-
caine will prove to be a useful and re-
liable method in our field of surgery,
though I will admit that disagreeable
symptoms will occasionally be notice-
able from its use. Repeatedly in my
cases a slight dyspnea was observed ;
the pulse-rate increased to 100, in two
cases to 120; involuntary defecation
occurred in three cases, and in the
case of the above-mentioned woman,
where no analgesia was effected, pro^
fuse vomiting followed the injection of
the drug. But all those disagreeable
sequels were the exception ; as a rule
the analgesia was complete, and the
operation could be finished without
any interruption caused by the intra-
spinal injection. The same favorable
results were obtained as regards after-
effects. I have never observed the ex-
cruciating headache so often noticeable
after spinal cocainization, and I am in-
clined to believe with Bier (8) that
neither the difference in pressure of
the cerebro-spinal fluid nor circulatory
disturbances, but the toxic effect of
the cocaine is the real cause of this
distressing symptom. In regard to
increase of temperature as a sequel of
spinal anesthesia with tropa-cocaine,
I cannot express a decided opinion. In
the few of my cases where it occurred
I was not certain whether the condi-
tion of the wound was not the cause
of this symptom.
The majority of my operations lasted
less than an hour. Only in one case
(an external urethrotomy with total
obliteration of the urethral canal) we
worked one hour and forty minutes
with complete analgesia after injection
of 0.05 tropa-cocaine.
The only real danger, to my mind,
connected with this method of anes-
thesia lies in the possibility of sepsis
to the spinal canal. Therefore, I
would not attempt spinal anesthesia in
a private dwelling. In the hospital I
have the patients in whom spinal anes-
thesia is to be made prepared as for a
laparotomy. The day before the oper-
ation the patient gets a full bath, his
back is shaved and a sublimate-pad ap-
plied upon it. On the operating table
the field of the puncture is sterilized
as carefully as the site of an abdominal
section.
I hope you will test this method un-
biasedly in your genito-urinary sur-
gical work, so that well-established indi-
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Abstracts.
cations for this method of anesthetiz-
ing may be drawn from for future
experience. My work teaches me that
the method seems to be impracticable
in very nervous and excitable patients.
I can highly recommend it, though,
for old and decrepit individuals, where
a weak heart or unreliable kidneys
would contra-indicate a general anes-
thesia. I have not had a mishap in
my spinal anesthesia with tropa-co-
caine so far, and I consider this method
not to be more dangerous than any
other form of anesthetizing, while its
advantages over general anesthesia for
the patient are unquestionable.
REFERENCES.
1.— J. L. Coming: New York Medical Jour-
nal, October 31, 1886.
2.— Dudley Tait and Guido Caglieri: Trans-
actions of the Medical Society of the State of
California, 1901, p. 266.
3.— A. W. Morton: Transactions of the Med-
ical Society of the State of California, 1901, p.
228.
4.— I. V. Mikulicz: Arch. f. Klin. Chir.„
Vol. LXIV, p. 767.
6.— F. Kammerer: N. Y. Med. Monatsschr.,.
1901, p 1.
6.— W. Meyer: Med. News, Vol. LXXVIII,
p. 669.
7.— Karl Schwartz: Centralbl. f. Chir.,1901,.
No. 1.
8.— Aug. Bier: Arch. f. Klin. Chir., Vol.
XLIV, p. 236.
ABSTRACTS.
THE IMPORTANCE OF DtAONOSIS !N
SKIN DISEASE.
Dyer, in The Medical News^ gives
the following important points in the
diagnosis of skin diseases: (1) The
location of the disease; (2) the dis-
tribution on the particular region on
which it occurs; (3) the arrangement
of the component parts or lesions.
The lesions themselves must be studied
in detail so as to classify the disease.
Eruptions which are bilaterally sym-
metrical are either constitutional in
origin or are exposed to the identical
local cause on both sides of the body.
Parasitic diseases are found on the
flexors preferably, or on the exposed
parts of the body. The more chronic
diseases of the skin become, the deeper
the color; on the other hand, the
brighter and more vivid the color, the
more acute the disease. Scales, ulcers
and scars are the evidences of chron-
icity. Fluid lesions seldom itch.
Papular eruptions almost always itch.
Single ulcers are almost always syph-
ilitic, trophic, traumatic or malignant.
On the face ulcers are seldom due to
other causes than cancer, syphilis or
tuberculosis. The color of eruption
on the Caucasian is always important
in diagnosis. Syphilis is pigmented
brown or buff as its eruptions fade.
Leprosy is shaded brown or purple.
Lichen rubor is violaceous or white.
Psoriasis is always pale red, covered
with white scales. Seborrheic eczema
is always yellow red, with greasy
scales. Syphilis, when ulcerating,
smells rancid; favus has a mousy
odor; varicose ulcers smell sweet;
neurotic ulcers or those of leprosy
are nauseous and foul, while rodent
ulcer has the smell of rotting meat.
SUPRAPUBIC PROSTATECTOMY.
Taylor, in the Dublin Journal of
Medical Science^ makes the following
statements: (1) It is an operation
from which good results may be ex-
pected in suitable cases; (2) it is
doubtful if the operation should, as a
rule, be attempted in very old men if
their vital powers have reached a low
ebb, and in whom it is probable that
there is grave organic renal disease
associated with chronic cystitis of long
standing; (3) in absence of severe
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i&
cystitis, provided the patient's general
health is fairly good, the suprapubic
operation which the author describes
raay be employed without obvious
risk; (4) in prostatectomy, as in
other operations of an extensive char-
acter, it is desirable that the various
steps of the procedure be carried out
in as expeditious a manner as possible,
consistent, of course, with safety and
efficiency ; ( 5 ) suprapubic prostatect-
omy, as practiced at the present day,
aims at enucleation of encapsulated
growths, and meets all the require-
ments of the case.
INPANTILB SYPHILIS.
Martin reports (Munch. Med. Woch-
enschrift) the statistics of the medical
clinic of Jena, from the years 1860 to
1890, regarding infantile syphilis. Al-
together there were fifty-six cases, of
which thirteen were acquired and for-
ty-three heriditary. Of the thirteen
acquired cases, the source of infection
could be determined in six. Of these
thirteen, two died in the clinic, one of
pneumonia and the other of diphtheria.
Seven patients lived to adult life ; four
passed from observation. In one case
the patient had tertiary symptoms at
the age of eleven. The others, with
the exception of an occasional infec-
tious disease, remained well. Of these
seven cases two were men, both mar-
ried, had large families, and all the
children were healthy. Of the five
women three are married and have no
children. One had one child that died
at the age of two years. A fourth
has had eight children, of whom six
are still alive. All the children were
fairly intelligent, and showed no moral
or physical defect. Of the forty-two
eases with hereditary syphilis, twenty
males and twenty-two females, thir-
teen showed symptoms of the disease
very early and thirty not until the fifth
year. Of the thirteen cases of pre-
cocious hereditary syphilis three passed
from observation. Of the remaining
ten, seven died in early childhood, and
one at the age of eighteen, of pulmon-
ary tuberculosis. The patient was ap-
parently quite intelligent. Of the re-
maining two cases one is probably
still alive. One of them was morally
defective, and his parents were the
same. The other was fairly intelligent,,
married, and has two living children.
Of the thirty cases of late hereditary
syphilis, three males died at the age&
of nine, eleven and fifteen years. One
of these was remarkably intelligent;
another was morally defective. Two
patients died at the ages of seventeen
and nineteen years. The causes of
death in all cases may have been
syphilis. As for the other patients,
it appears that, as far as was known,
they are all married, and have children
that are fairly healthy. Among the
women there can be no doubt that
there wa? some delay in the appear-
ance of puberty. Of the thirty-three
children born up to 1900, five had
died. There were also numerous mis-
carriages. — Philadelphia Med. Jour^
nal.
VITILIGO OP SYPHILITIC ORIGIN.
At a meeting of the Society of Der-
matology and Syphilography MM.
Pierre Marie and Crouzon exhibited a
patient whohadavery extensive vitiligo
which had been progressively develop-
ing for about twenty years. He had
also a very pronounced buccal leuco-
plakia. The patient denied having had
syphilis, and presented no sign of that
disease, except a double papillary
atrophy and a modification of the pu-
pillary reflexes. The authors never-
theless believed that the vitiligo and the
leucoplakia had a common origin, and
insisted upon the relationship between
vitiligo and syphilis. They referred to
cases of the kind reported by du Castel
and Tenneson, among others, and to
the occurrence of vitiligo in certain
nervous diseases, the relations of which
to syphilis are without doubt.
M. Darier said that the syphilitic
origin of vitiligo, impossible to admit
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in certain cases, in others appears very
probable. He had observed a case in
a lady, thirty-five years of age, who,
indeed, herself showed no signs of
syphilis, but who had been married for
seventeen years to an undoubted syph-
ilitic. She exhibited at the same time
not only the purely epithelial lesions
of leucoplakia, but also superficial
sclerosis of the tongue. She had like-
wise had vitiligo for two years.
Therefore, in establishing a funda-
mental difference between congenital
and acquired progressive vitiligo it is
necessary, in the latter cases, to look
for syphilis.
M. Brocq said that in such cases we
should mistrust coincidences and adopt
the view of an etiological relationship.
He had at the time under his care a
patient who had an old vitiligo, acquired
and progressive, of the genital organs,
and who also had syphilis. — La Tribune
Medicale.
BULLOUS (EDEMA OF THE BLADDER.
Of this very rare affection Dr. Lin-
•denthal has observed one case in con-
sequence of the application of apessary.
A woman, fifty-two years of age, was
attacked by cystocele, with uterine pro-
lapse, and it was judged well that she
should wear an annular pessary. It had
been in position but a few days when
she was assailed by symptoms of cys-
titis with tenesmus. A cystoscopic
examination showed the existence of a
bullous ofidema in the region of the
trigone. The pessary having been
withdrawn, the vesical symptoms, ob-
jective and functional, subsided almost
at once. Upon the mucous membrane
of the bladder nothing was to be seen
but a small, hsemorrhagic spot. The
pessary was replaced, but immediately
the vesical tenesmus and osdema reap-
peared. The pessary being removed
a second time, the oedema was absorbed,
but at its site were seen small spots of
haemorrhage and partial necrosis of the
mucous membrane. The last accidents,
except the oedema, being reproduced
each time that the pessary was reap-
plied, the patient consented to an opera-
tion for the relief of the uterine pro-
lapse. Care was taken in performing
vaginofixation to make attachment at
some distance from the bladder, for
fear of favoring increased necrosis of
the mucous membrane and perforation
of the bladder.
It is to be supposed that in this par-
ticular case the bullous oedema and
necrosis consecutive to compression by
the pessary found some adjuvant con-
dition in a rather special distribution
of the vessels. — La Tribune Medicale,
RADIOTHERAPY AND PHOTOTHERAPY IN
CARCINOMA, TUBERCULOSIS AND
OTHER DISEASES OF THE SKIN.
Hyde, Montgomery and Ormsby
(Journal of the American Medical
Association, January 3, 1903) present
an interesting paper on the use of the
X-rays and the actinic solar rays in the
treatment of carcinoma, tuberculosis,
psoriasis and various other skin dis-
eases. They report twenty-one cases,
and from these and from a considera-
tion of the literature believe that they
are justified in drawing the following
conclusions :
While it is too early to form definite
and sweeping conclusions regarding the
value of radiotherapy and phototherapy
in all the affections in which they have
been employed, our experience leads
us to believe that in tuberculosis of the
skin these methods of treatment are
superior to any others now known to
us. In lupus erythematosus, photo-
therapy has in our hands given very
satisfactory results, far better than
those we have obtained by any other
method.
In superficial carcinoma involving
considerable areas, radiotherapy is
undoubtedly preferable to all other
known methods of treatment. Super-
ficial lesions more circumscribed are
equally amenable to treatment with
the X-rays, though in many instances
small tumors can be removed more
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Abstracts.
81
promptly by complete erasion or ex-
cision. For many of these circum-
scribed growths we are now inclined to
advocate removal either with the knife
or curette, followed by a series of
treatments with the X-rays. In oper-
able carcinoma of the skin which in-
cludes deeper tissues we advocate com-
plete extirpation, followed by X-ray
treatments. Where the growths are
inoperable radiotherapy offers a possi-
ble chance of recovery, or of lessening
the discomfort of the patient. As a
result, however, of our observation of
our own and other cases, we believe
that in exciting an inflammation in car-
cinoma one is, to some extent at least,
encouraging an extension of the growth
through a dissemination of the cancer-
cells to normal (or inflamed) tissue.
We believe this possibility constitutes
s, danger in the treatment of carcinoma
by the X-rays that has not been suffi-
<;iently recognized.
The value of radiotherapy in exten-
sive cases of hypertrichosis has been
fairly well established by other ob-
servers. It has given us excellent re-
sults in the majorty of cases of psori-
asis treated. It has unquestionably
been used successfully in many of the
chronic inflammatory diseases of the
skin, especially in acne, rosacea, fol-
liculitis, and suppurating wounds, but
until this agent can be employed with
greater accuracy we believe it should
be reserved chiefly for those cases in
which better known and better con-
trolled methods are not successful.
It is not yet possible to draw definite
conclusions with reference to the com-
parative values of radiotherapy and
phototherapy. The former is, for the
most part, readier of application, and
apparently has a wider field of useful-
ness than the latter. In lupus ery-
thematosus, however, phototherapy
has repeatedly given us excellent re-
sults where the X-rays have failed al-
together or aggravated the condition.
Judging from our experience and from
the larger experience of Finsen and
others in the treatment of tuberculosis
of the skin, we believe that in this dis-
ease phototherapy gives in the end re-
sults as rapid as those obtained with
the X-rays, with better cosmetic ef-
fects, and without danger of deep burns
There is no doubt that phototherapy
and radiotherapy are valuable addi-
tions to our methods of treating cer-
tain diseases. There is also no doubt
that their field of usefulness eventually
will be proven much more restricted
than that in which they are employed
at present. Unfortunately, there can
be no doubt also that harm is doing
and will be done by the action of
X-rays in the hands of the unskilled or
the unscrupulous. No one should at-
tempt to employ radiotherapy who has
not first carefully studied the subject
and followed the work of some expert.
Even with such preparation great cau-
tion is needed in acquiring experience
with this new therapeutic agent, its
accurate control and the character of
results obtained being still subjects of
discussion.
ACIDS INTERNALLY tN PRURITUS.
Prof. H. Leo, of Bonn (Semaine
Medicale, xxii. No. 51), recommends a
trial of hydrochloric or sulphuric acid
in all cases of generalized pruritus of
obscure origin, whether there bealka-
linuria or not. Sometime ago he was
called to a man suffering for more than
a year from very intense generalized
pruritus. Nothing abnormal could be
discovered save an alkalinity of the
urine due to an increased elimination
of phosphates ; so the doctor ascribed
the pruritus to hyperalkalinity of the
blood. Accordingly he prescribed a
50 per cent, solution of hydrochloric
acid in doses of ten drops every two
hours. As a result, the pruritus di-
minished in intensity, and the urine
became clearer. After several days a
li per cent, solution of sulphuric acid
was given, a tablespoonful every two
hours, and still later the strength was
increased to 2^ per cent. The pruritus
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82
Abstracts.
soon disappeared completely. Dr. Leo
has applied the same treatment with
success in another case of generalized
pruritus and in a case of vulvar pruritus.
In these three cases the urine was
alkaline; but in three other cases it
was of normal reaction before institut-
ing the treatment, and yet the results
were very satisfactory. Of course,
there were some instances in which no
success was had. — Phila. Med. Jour.
TREATMENT OF SYPHILIS WITH INTRA-
VENOUS INJECTIONS OP MERCURY
CYANIDE.
Renault {Oaz. Hehdom., 1902, No.
55 ; abstract from Derm. Centralblatt^
September, 1902) has obtained good
results with injections of mercury cy-
anide into the veins of the arm. He
uses a 1 per cent, solution and gives 1
c. c. every day or every other day.
The injections are painless, and the
action is rapid and sure, particularly
in affections of the nervous system.
The author treated fourteen cases of
syphilis ; three of these patients had
secondary syphilis with severe head-
aches, three hadgummata of the tongue
arid gums, two had medullary disease,
four had severe tertiary headaches, and
one had Jacksonian epilepsy. In all
of these the improvement was rapid,
the headaches disappeared, as a rule,
after the first injection, as likewise did
the epileptiform seizures. In the dis-
cussion the following objections to the
treatment were made: The injections
are difficult to carry out in fat persons ;
it has been shown that even weak so-
lutions of mercury bichloride are capa-
ble of producing phlebitis and throm-
bosis ; it has not been proved that this
method is superior to the treatment
with the unctions and potassium iodide.
— Phila. Med. Jour.
CUTANEOUS ANQIOMATA.
Symmers {Med. News^ Dec. 27,
1902) found that in comparatively
young persons, who exhibit the above
mentioned skin changes, there was
present high arterial tension. Evei>
further signs of precocious arterial
sclerosis were commonly observed. In
individuals between forty and fifty
years of age, actual arterial hardening
went hand in hand with cutaneous an-
giomata. He considered that the skin
affections bore no relation to malignant
disease, and that their existence, even
in large numbers, is not to be viewed
with any degree of alarm as far as
cancer is concerned.
RECURRENT BULLOUS ERUPTION.
Gottheil (Jour. Amer. Med. Assoc. y,
Dec. 27, 1902) observed a recurrent
bullous eruption, in a child five and
one-half years old, coming on in the
fall of four successive years, which ran
a definite course and was unaccom-
panied by the other symptoms usually
met with in lesions of this nature. It
was not related to an injury, and there
was no hereditary history. It was not
a bullous urticaria, for there was no
itching, nor were there any other urti-
carial lesions ; and the same argument
holds for bullous erythema. Dermatitis
herpetiformis is grouped and inflam-
matory; this eruption had neither of
these characteristics. A cantharidal
eruption could be excluded. He con-
sidered the disease probably benign
pemphigus on account of its periodicity
and the absence of an inflammatory
areola around the bullae.
HERNIA OF THE BLADDER.
Lossen {Beitrage zur hlin. Chirur^
gie, Band 35, p. 140) reports three-
cases of hernia of the bladder and an-
alyzes the literature. The condition
has been estimated by different observ-
ers as occurring in from 1 to 6 per cent^
of all herniee. In 3,000 hernia opera-
tions, in 1.6 per cent, a portion of the
bladder was found. Hernia of the-
bladder occurs more frequently through
the inguinal canal than through the-
femoral canal. The protruding por-
tion of the bladder may or may not be-
covered by peritoneum. In the ma-
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88
jority of cases there is an accorapany-
ing enterocele. As a rule, there are no
special symptoms in this variety of
hernia, the diagnosis being made only
after the incision has been made. Of
twenty-nine cases in which strangula-
tion occurred the diagnosis was made
before operation in five only. Even
during operation a hernia of the bladder
js apt to be unrecognized, and in a
number of cases it has been opened be-
fore the condition has been diagnosti-
<5ated. A large amount of subperi-
toneal fat or a distinct lipoma should
put one on guard for a bladder pro-
trusion. If the bladder wall itself be
seen or its lateral ligament be made
out, a mistake would be less likely to
happen. Treatment consists in reduc-
ing the herniated bladder and closing
the canal in the usual way. In some
<3ases, in which there is a pouch-like
formation of the bladder, resection is
the proper procedure. — Phila. Med.
Jour.
A CENTURY OF ARM-TO-ARM VACCINA-
TION.
Eduardo Liceaga {Indiana Medi-
<;(7Ze7owrn</7) describes the method of
arm-to-arm vaccination which has been
practiced for one hundred years in
Mexico, the greatest care having been
exercised as to the choice of candidates
for propagating the virus. As to the
results, it has been observed, in the
first place, that persons vaccinated in
this way remain immune during their
whole lives. When there is a wide-
spread epidemic it is stopped in no
time by at once vaccinating all persons
who have not been previously so
treated. The immunity which vacci-
nation confers on infants is preserved
during the whole of their lives. No
Mexican physician has ever died of
smallpox, even if has been in practice
for forty years. The same immunity
has been observed in male and female
nurses who attended smallpox patients.
Experiments undertaken by order of
the supreme board of health of the
City of Mexico, show that vaccinations
succeeded exceptionally well. Of
1,307 revaccinations only twenty-three
were successful. — Exchange.
THE TREATMENT OF SCARLET FEVER.
Adolf Baginsky (Berl. klin. Woch.,
December 8, 1902) believes that scarlet
fever is caused by streptococci. He
used first the old Aronson antistrepto-
coccus serum, with a mortality of 11
per cent. At the same time the mor-
tality in cases treated without this
serum was 14 per cent. The new
Aronson serum, on the other hand, re-
sulted in marked diminution of all
symptoms almost at once. This serum
together with the new Moser serum
seems to Baginsky to give a brighter
outlook for the treatment of scarlet
fever. — Phila. Med. Jour.
VULVITIS IMPETIOINOSA IN YOUNQ
CHILDREN.
In the Bulletin Medical (December
27, 1902), Carriere reports the detailed
case-histories of three little girls with
impetiginous vulvitis. These children
were disposed to attacks of impetigo
of the skin, which, like the vulvitis,
also began with slight fever. The vul-
vitis in its course resembled impetigo,
even containing the same staphylococci
in the fluid of the vesicles. Impetigo
of the skin complicated one case, and
in another it followed inoculation of the
arm with fluid from the vulva. The
inguinal glands were swollen in all
cases. In the treatment he used hydro-
gen peroxide locally and iron protiodide
and cod-liver oil internally. [M. O.]
—Ex.
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New Publications
NEW PUBLICATIONS,
D18EA8SS 07 THE Skin. Their Description, Pathology,
Diagnosis and Treatment, with special reference to
the skin eruptions of children, and an analysis of fif-
teen thousand cases of skin disease. By H. Rad-
cliitb-Crocker, M. D., P. R. C P., Physician for
Diseases of the Skin in University College Hospital;
Honorary Member of the American Dermatological
Society, etc. Third edition, revised and enlarged,
vfith four plates and one hundred and twelve illus-
trations. Philadelphia: P. Blakiston's Son & Co.,
1012 Walnut street. 1903.
This standard work has been very
much improved in many respects. It
has been enlarged by the addition of
new matter to the extent of covering
over 1400 pages, and much of the text
has been rewritten in order to bring it
up to date. The classification is the
best that could be devised for the use
of students. Each disease in the clas-
sification is also accompanied by a de-
scription of the most prominent pri-
mary lesion, as well as presumed etiol-
ogy and pathogeny. The greatest
trouble with the young practitioner is
encountered in dealing with skin erup-
tions of children, and the author rec-
ognizing that fact has given special
attention to this class of cases. For a
thorough mastery of skin diseases the
student or physician can find no better
guide than the above elaborate treatise.
BiooRAPHio Clinics. The Origin of the Ill-Health of
De Quincey, Carlyle, Darwin, Huxley and Browning.
By Georoe M. Gould, M. D., Editor of American
Medicine, author of "An Illustrated Dictionary of
Medicine, Biology," etc., "Borderland Studies," '^The
Meaning and Method of Life/' etc. Philadelphia: P.
Blakiston's Son & Co., 1012 Walnut street. 1903.
The above little volume will be read
with more than usual interest by mem-
bers of the medical profession, not
alone on account of its bearing on pro-
fessional subjects, hut from a histor-
ical standpoint. In studying the his-
tory of great men we seldom know
anything of the physical infirmities
under which they performed their
wonderful tasks. We see the revela-
tion of genius in the lines of the poet,
and in the eloquence of the orator, but
we know nothing of the bodily ail-
ments which hampered their intellect-
ual efforts. The author selects five
great historical characters, and holds
up the mirror to their inner lives, and
in this mirror we see images of their
daily lives, which have escaped biog-
rapher and historian.
The American Yeab-Book of Medicine and Surqebt
FOR 1903. A Yearly Digest of Scientific Pro^ss and
Authoritative Opinions in all Branches of Medicine
and Surgery, drawn from Journals, monographs and
text-books of the leading American and foreign au-
thors and investigators. Arranged, with critical edi-
torial comments, by eminent American specialists^
under the editorial charge of Gkobqe M Gould, A.
M., M. D. In two volumes— Volume II, General Sur-
Sery. Octavo. 670 pages, fully illustrated. Phila-
elphia. New York, London: W. B. Saunders ft Co.
1903. Per volume: Cloth; ^.00 net; Half Morocco,
^75 net.
We do not know of any similar pub-
lication, either American or foreign,
that can compete in any way with thi&
excellent Year-Book, published by
W. B. Saunders & Company. It is not
an indiscriminate collection of extracts
clipped from any and every journal ;
the matter is carefully selected, edited,
and in numerous cases commented upon
by the eminent authorities whom Dr.
Gould has enlisted as his assistants.
Every new theory and scientific discov-
ery worthy of the consideration of the
professoin has found a place in this
unusually complete Year-Book; and
the names of the several editors are
suflScient guarantee of a proper dis-
crimination. As usual, the illustrative
feature is well taken care of, there
being eleven full-page inserts, besides
many excellent text-cuts. We strongly
recommend Saunders' American Year-
Book as the best work of its kind on
the market.
Clinical Tbbatisks on the Patholoot and Therapy
OP D1SORDEE8 OP Metabolism and Nutrition. By
Prof. Dr. Carl von Noorden, of Frankfort, Germany.
Authorized American edition translated under the
direction of Boardman Reed, M. D., Philadelphia. Part
I, Obesity. Part II, Nephritis. E. B. Treat & Co.,
New York, Publishers. 1903.
The above are two very interesting
and instructive little volumes. The
author takes very broad and comprehen-
sive views of the diseases discussed. He
elaborates their pathology along the
lines of metabolism and nutrition. He
shows that the reduction method in
obesity must be properly selected and
directed in accordance with the age and
general physical condition of the pa-
tient. His dietetic, hygienic of ther-
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HYDROZONE is put up only in extra small, small, medium and large size bottles
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Therapeutic Suggestions.
apeutic procedures are not so rigid or
restrictive as to prescribe the same
rules for the management of all cases,
but are broad and elastic enough to
meet the requirements of individual
conditions. In obesity he is opposed
to prolonged and excessive efforts to
reduce corpulence, and advises inter-
mittent reduction with intervals of
muscular and physical training. In ne-
phritis, his aim is to increase the func-
tions of the skin and relieve the kid-
neys as much as possible of the
burdens of excretion.
THERAPEUTIC SUGGESTIONS.
Tinea circinata — especially in
that very troublesome form of the dis-
ease which affects the scrotum and
inner side of the thigh— yields promptly
to the application of borobenphene
(Heil) used three or four times a day.
In calculous affections lithiated
hydrangea is of unquestionable utility.
Its administration promotes the re-
moval of gravel from the bladder and
relieves pain during the passage of
renal concretions through the ureters.
Anasarcin has been employed with
marked benefit in renal dropsy, and in
various diseases of the kidneys accom-
panied by edema. Skim milk diet with
the above treatment is advised.
The condition of debility and faulty
assimilation which results from the
prolonged treatment of syphilis with
mercury and iodine is remarkably im-
proved by Gray's glycerine tonic
compound. The syphilodermata, when
occurring in cachectic subjects, are
benefited by a persistent use of the
same remedy.
In cases in which there exists a con-
dition of faulty assimilation of fats,
cod-liver oil, by reason of the fact that
it contains in intimate association the
bile elements, is especially adapted to
form the molecular basis of the chyle.
In scrofula, and other disorders of the
nutritive functions belonging to this
group, cordial cod-liver oil compound
(Hagee)is the best agent foi\ promot-
ing constructive metamorphosis.
EcTHOL is very serviceable in chil-
dren with soft and red tubercular
eruptions on the skin which ulcerate
and furnish a large quantity of un-
healthy pus. The steady use of ecthol,
combined with suitable hygienic means,
will accomplish important relief in such
cases.
Resinol is an excellent remedy for
allaying irritation in pruritus and urti-
caria. In eczema with pruritus, resi-
nol is one of the most effective appli-
cations for that very troublesome dis-
order.
Absolute accuracy of dosage is not
obtainable in capsules containing
merely a mechanical mixture of oils
and solids.
Tabsules and tabsoids overcome this
defect. They are attractive, neat and
clean, and appeal at once to the careful
physician.
Order your methylene blue formulas
in tabsules (Merz). No more expen-
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and complete list write Merz Capsule
Company, Detroit, Michigan.
Various Uses of Iodipin. — Dr. E.
J. Feibes, in charge of a sanatorium
at Aachen, Prussia, reports on his
extensive experience with iodipin
(iodized sesame oil) during the past
few years. He used the 25 per cent,
strength exclusively; usually hypo-
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Therapeutic Suggestions.
dermically, sometimes per os in cap-
sules or with beer. The iodipin was
readily assimilated, as shown by the
prompt presence of iodipin in the sa-
liva and urine. In sixteen cases of
malignant early syphilis iodipin ren-
dered most excellent service ; in every
instance the symptoms disappeared
within a relatively short time. In one
patient in whom mercury was not tol-
erated and potassium had no effect,
daily injections of 50 gm. (12 dr.)
iodipin, 25 per cent., were well borne,
and in four days brought about a com-
Elete change m the symptoms which
ad for eight months previously re-
sisted subcutaneous mercurial injec-
tions. Of three cases of rectal syph-
ilis, in two cure followed the daily
inunction with 6 gm. (1^ dr.) of mer-
curial ointment and the injection of
25^ gm. (6 dr.) of iodipin, 25 per
cent. ; while in the third case, in which
mercurial inunctions and potassium
iodide were ill borne, the hypodermic
use of iodipin alone promptly resulted
in recovery. In sixty-three further
cases of general syphilis speedy recov-
ery was effected by the combined use
of mercurial inunctions and iodipin
injection ; and there were no relapses,
as had previously occurred in a num-
ber of the cases after the customary
treatment with mercury and potas-
sium iodide. In nasal syphilis iodipin
rendered good service, and is preferred
by the author to potassium iodide ex-
cept in acute cases. He has treated a
large number of necrosed nasal bones,
and always achieved excellent results.
The putrid masses adhering to the
ulcerated surfaces are very quickly de-
tached, and no coryza is produced.
Dr. F. has used iodipin, 25 per cent.,
in quite a series of cases of syphilis of
the nervous system — hemiplegia, cere-
bral syphilis, spastic spinal paralysis,
and locomotor ataxia. ^ ThermaJ baths,
inunctions and iodipin injections con-
stituted the treatment which proved of
more than usual efficacy. In cases of
obstinate specific adenitis and perios-
titis, the author injected 1 gm. (15
min.) of iodipin, 25 per cent., in the
region of the diseased part. A com-
pressive dressing of cotton was applied
in the periostitis cases, so as to pre-
vent diffusion of the iodipin. The in-
jection was repeated as a rule but
once, general treatment usually suf-
ficing to complete the cure. The ben-
eficial results manifested themselves
very promptly in a few days.
Finally, Dr. F. has treated psoriasis
and sciatica with iodipin. In five cases
of the latter he injected 5 gm. (75
min.) along the course of the nerve.
In three the result was striking ; the
pains rapidly subsided, and the free
use of the limb was speedily restored.
Sometimes four injections were given
at one seance. In the three psoriasis
cases, some of years' standing, warm
baths containing some creolin, inunc-
tions with green soap, and injections
of iodipin 25 per cent., soon brought
about a marked improvement, so that
the cure could be readily completed by
an ointment of white precipitate, green
soap and vaselin.
Where the patient I'efuses injec-
tions, Dr. F. gives the iodipin per os,
up to 30 gm. (1 oz.) per day. Rectal
administration is considered superflu-
ous. — Dermal. Ztschr.y 1902, No. 9.
Prevention of Cystitis. — In cases
where frequent catheterization of the
bladder is necessary there is always
danger of producing a cystitis even
with the most constant attention to pre-
ventive measures. With such patients
it is not wise to wait until the bladder
has become distended, but to catheter-
ize at short intervals (from three to
four hours), of course giving proper
care to the instruments.
As an auxiliary prophylactic measure
cystogen, grs. v twice daily, should be
given. This inhibits the growth of
bacteria in the urine and prevents irrita-
tion of the neck of the bladder, so fre-
quent and annoying in these cases.
This precaution is also advisable before
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20 min. (in acute) to 60 min. {in chronic) of Sander's Eucalyptol to the ounce of
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then paint the ulcer with Sander's Eucalyptol, full strengths and apply occlusive
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To avoid the irritation so frequently following the application of the common products of
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Therapeutic Sucgestiqhs.
and after prostatectomy, cystotomy,
the passing of sounds, and in all surgical
interference of the urinary tract, also
during the course and following re-
covery from typhoid fever.
When a cystitis has become estab-
lished, cystogen will be found effective
in rendering the urine clear and non-
irritating and an importi^nt adjunct in
restoring the organ to a normal condi-
tion. The dose in these cases should
be increased to grs. v, four times daily.
The Vegetable Kingdom has yield-
ed another valuable drug to our arma-
mentarium which has proven itself of
value to dermatologists in the treatment
of the various forms of eczema, tinea
and kindred obstinate skin affections.
It is best adapted for office practice,
lending itself to various modifications
and admixtures with diluents such as
alcohol, glycerine and the like. Prompt
results are obtained in the minor skin
affections of the genitals and scalp.
Chaparrin, the active principle of the
shrub known as chaparro amargosa, is
the preparation referred to and is of-
fered the profession by the Matthewson
Laboratory of Marshall, Texas.
Typhoid Fever — In the treatment
of this disease it is necessary to con-
trol the patient's temperature and to
keep the alimentary canal in as nearly
aseptic condition as possible. The ef-
fort of the physician must, however,
be directed toward preventing intesti-
nal perforation. No other remedy will
accomplish this end more readily or
more satisfactorily than Daniel's cone,
tine, passiflora incarnata. ThQ ex-
perience of the medical profession
justifies the confidence which it has so
often expressed. In the whole intes-
tinal tract this remedy acts as a seda-
tive and hypnotic. It does not lessen
the supply of blood to any organ of
the body, but gives natural and con-
sistent nerve rest. Daniel's passiflora
does not impair the heart action or
produce constipation, but as a mild
laxative and diuretic acts pleasantly as
an eliminant and nervine.
Daniel's cone. tine, passiflora in-
carnata not only relieves * 'after
pains" speedily, but it acts as a mild
laxative and diuretic and it is therefore
an ideal remedy in this condition.
When once a physician has given this
remedy a thorough trial he will never
revert again to morphine, camphor, or
any of the old-time injurious drugs. —
William A. Donovan, M. D.
A Report of Two Cases of Septi-
c-s:mia Successfully Treated with
Hg Oj Medicinal. (By E. J. Melville,
M. D., Bakersfield, Vt.)— (7a«e 1.—
February 6, 1894, was called to see
Homer B., aged fourteen, who had
been ill with a swelling in right groin
for three weeks. Had been treated
with hot applications, etc., but during
that time abscess continued to grow,
and at the time that I first saw him
fluctuation could easily be made out.
Temperature 102.5° F. Pulse 120.
.Great emaciation. Constant vomit-
ing. Daily chills followed by copious
sweating, denoting pus absorption.
Diagnosed appendicular abscess and
advised operation. This was done same
day under local anesthesia.
Much pus escaped, and several small
portions of fecal matter, denoting an
opening into the gut.
Temperature remained high, and
sweats continued for three days fol-
lowing operation, indicating the pres-
ence of pus. I then began the use of
Marchand's H^ Oj medicinal (15 vol.),
so as to destroy the pus and morbid
element which were still there. I in-
jected four ounces of Hj Oj with a glass
syringe slowly, while patient was in
the Trendelenberg position, and al-
lowed it to remain about fifteen min-
utei. The boy was then lowered and
laid upon his right side, when large
quantities of pus, broken down tissue
and gas flowed from wound. By gentle
compression and massage of abdomen,
much more was obtained. Large quan-
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If you know a thing to be a fact, it is not wrong or
unethical to say so. Neither does it smack of quackery or
Charlatanism and should not shock the sensibilities of any,
however refined, cultured or zealous of medical ethics for us
to claim that ANASARCIN is a specific in dropsies, when
clinical experience has demonstrated such to be a fact. If
quinine is a specific in malaria, much more is ANASARCIN
in dropsies resulting from disease of the heart, liver or
kidneys, because that a trial of it in hundreds, yea, thousands
of cases has not resulted in a failure known to us where
directions have been followed.
Besides being a specific for dropsies, it is a permanent
cure in the conditions mentioned when begun early and
continued a sufficient length of time, i, e.^ until the diseased
organs regain normal function. ANASARCIN is composed of
the active principles of Ozydendron Arboreum, Sambucus and
Urginea Scilla, and is sold exclusively to physicians or
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Therapeutic Suggestions.
titles of sterilized gauze were packed
over the opening in right side.
The flushing out with Hj O^, etc.,
was repeated every twelve hours.
Theimprovement was prompt. Tem-
perature reached normal, and remained
so after forty-eight hours.
Wound was now washed out with the
Hj O2 daily for four weeks, after which
time the abdominal wound and faecal
flstula were entirely healed. Patient
has since developed into a full-grown
laboring man, and has had no hernia
nor any outward symptoms of his
severe illness.
Case 2. — March 2, 1897, was called
to see George T., a farmer, aged
thirty-eight years, who had been in the
care of a Christian scientist for four
weeks for a large swelling in right
side. The treatment consisted in en-
deavoring to persuade the man that he
was not ill, and insisting that he take
active exercise. Found patient in re-
cumbent position with knees flexed
upon abdomen, and suffering intense
pain over right side of abdomen, which
was filled with a soft fluctuating mass.
Temperature 103.8° F. Pulse 130.
Opened abdomen under local anes-
thesia and evacuated three quarts of
foul-smelling pus.
Used four ounces H^ O^ full strength,
slightly warmed, after pus had ceased
to flow, and repeated procedure every
twelve hours.
This caused cessation of all untoward
symptoms for eight days, when chills
and fever returned.
Another swelling was then noticed
in right lumbar region, which, upon
opening, gave one quart of pus.
Flushed this second abscess in same
way. The temperature soon reached
normal, and patient made an unevent-
ful recovery with exception of swell-
ing of inguinal glands in left groin,
which yielded in three days to hot
fomentations.
For conclusion I might say that in
the above cases I used no medicines
internally, and nothing externally but
clean linen, plain gauze and H, O,
(Marchand's).
The operations performed were sim-
ply opening abscesses, no drainage
tubes, no flushing with salt solution or
water, and no packing of abscesses.
Though I used the Hj Oj in large
quantities, and made no especial effort
to see that all the solution returned,
and though it was used over a period
of several weeks, no untoward symp-
toms developed from its use.
The above gratifying results induced
me to use hydrozone (which yields
thirty times its own volume of nascent
oxygen, instead of fifteen volumes) in
other cases where a large amount of
pus was present, with such good re-
sults thafe^I am now giving the prefer-
ence to this very strong solution.
INDEX
Original Articles. Paok.
Actinomycosis and Xray Therapy. By M. L. Heid-
ingsfeld, Ph. D., M. D. 47
Relation of the Ureter to the Bladder. By Byron
Robinson, B. S., M. D 49
Prurigo and Pruritus. By S. C. Martin, M . D. 54
Third Act in the Drama of Syphilis. By Henry Al-
fred Robbins, M. D.. 55
Elephantiasis in Japan. By Albert S. Ashmead,
M. D 58
Original Articles. Paox
A Sexual Pervert. By W. B. Parson, M. D 71
Social Position and Occupation as Etelated to the
Health of Women. By S. L.Eisner, M.D 72
Spinal Anesthesia With Tropa-Cooaine in Oenito-
Urinary Surgery. By M. Krotoszyner, M, D 74
Abstracts 78
New Publications _ 84
Therapeutic Suggestions 86
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A BI-MONTHLY MAQAZINK DKVOTEO TO THK CONSIDKRATION OF CUTANEOUS
VKNERKAL DISEASES AND QENITO-UfllNAflY SURQBflY.
MEDICINE
S. C. MARtiN, M. D.
or DERMATOLOOY IN THI BAflNCS MIOIOAI. OOLLtM
ST. LOUtS.
EDITORS
G. M. PHILLIPS. M. 0.
PWOriSSOR or aENITO-UmNARY OltCAMt ST. I.OU« <
PNVaiCIANS AND MIHaCONt.
MANAGING EDITOR
C. MARTIN. Jr.. M. 0.
SUBSCRIPTIONS AND ADVERTISING. .
The subscription price of this Toumal is |1.00 per ^ear, in advance, postage prepaid, for the United States, Canada
and Mexico; |1 SO per year for all foreign countries included in the postal union. Single copies, 25 cents.
Advertising rates will be furnished upon application.
Address all communications, correstMndehce, books, matter regarding advertising, and make all checks, drafts
and post-office orders payable to
AMERICAN JOURNAL OF DERMATOLOGY,
Fidelity Building. St. Louis, Mo., U. S. A.
Vol,, vn.
MAY, 1903.
No. 3.
PROSTATIC HYPERTROPHY PROM EVERY
SURGICAL STANDPOINT.
Arranged by Osobob M. PHiiiUPS, M. D.,
Editor*in-Chief Gtonito-Urinary Department American
Journal cf BemuUology and Genito-XTrinary Diteases,
and Professor of uenito-Urinary Surgery, St.
Louis College of Physicians and Surgeons.
The subject of hypertrophy of the
prostate is not new, but, on the con-
trary, is one that has engaged the at-
tention of medical men from the ear-
liest record. It is not a condition con-
fined to a given locality, nor is it one
appearing at particular seasons, but
one that selects for its victims men
who have passed the meridian of life
without regard to habit, former health
or activity. It is a condition not un-
usually considered a disease, yet, as
we will soon see, is a condition the
complications of which very often
strips the declining years of man of
the usefulness and pleasure for which
he has so long labored, and commits
to the grave yearly many who were
otherwise entitled to live. One is often
impressed with the idea that discov-
eries, inventions, improvements and
truly great advances travel in cycles
or waves, and this seems to hold true
with reference to the above subject.
Prostatic manipulation and considera-
tion within the past few years has been
very general. From every quarter
evidence has come of scientific work.
Men who for years have been silent
upon this subject have become awak-
ened. Surgeons in general have con-
sented, specialists in this department
have forged forward and blazed the
way, which has been taken up by all
who are interested in the betterment
of mankind. This issue of this jour-
nal is here devoted and, I might say,
dedicated to this class of workers.
The time devoted to the collection
and compilation of the views and ex-
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94
Original Contributions.
periencee of this talent and the space
given is our best acknowledgment of
appreciation.
Every one solicited to participate in
this matter has been asked for an an-
swer to the fourteen questions here
enumerated :
Question No. 1.
To what extent does occupation tend
to prostatic h^pei'tropbyf Answer
with especial rejbnsmx to w^ive indoor j
active outdoor and sedentary pursuits.
Question No. 2.
Which suffer oftenest^ the phlegmatic
or nervous? The lean or obese?
Question No. 3.
In brief J what is the etiology of
prostatic hypertrophy?
Question No. 4.
To what extent has the cystoscope
been of service in diagnosis^ and
what instrument is prefen'ed?
Question No. 5.
To lahat extent is habit responsible
for prostatic hypertrophy? Answer
tvith especial reference to the use of
alcohol and constipation.
Question No. 6.
Wfiai cases do you advise palliation ^
and of what does this consist?
Question No. 7.
Have you practiced ligation of the
vasa deferentia? How many cases j
and with what results?
Question No. 8.
Have you castrated for prostatic
hypertrophy? How often^ and with
what success?
Question No. 9.
Have yoic made the Bottini^ or some
modification of this operation? How
often and loith what success? Answer
with reference to complications^ perma-
nency of reliefs etc.
Question No. 10.
How often have you practiced supra-
pubic drainage^ and what is your esti-
mate of results?
Question No. 11.
How often have you made supra-
pubic pi'ostatectomy^ and what have
been the results obtained?
Question No. 12.
Bow often have you made a perineal
prostatectomy^ and with what success?
What incision in the perineum affords
you greatest room?
Question No. 13.
Which is the operation of your
choice J and why?
Question No. 14.
What unexpected complications have
arisen during the operation for pros-
tatic hypertrophy^ and what during
the post-operative conduct of the case?
A.
Give binef i*esume of your prostatic
work.
And their several responses collected
are here submitted.
Before entering upon the analysis of
these answers, however, it might be
well to briefly consider in a general
way some features of the prostate.
The author in so doing will be par-
doned for omissions, and any theory
or view that may be at variance
with those of others ; as far as possi-
ble he will offer such as he personally
believes, and which, for the most, are
those that are generally accepted. He
will be pardoned also for reference to
the anatomy and physioloffy of this
organ, for it might appear that the in-
telligence of the reader would in this
way be insulted. That this issue is to
be broadly circulated, and will fall
into the hands of many less versed
upon this subject than those contrib-
uting, it has been considered well to
have it convenient.
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PROSTATIC Hypertrophy.
96
Anatomy of Prostate. — The pros-
tele is a muscalo-glandular body, quite
three^foortJis being muscular of the
unstriped wmtiety and one^fourth
glandular tissue (fmeoam). In size
and shape it is likened 'io n iiorse
chestnut. More scientific, it is in shape
a truncated cone measuring in length
30 to 45 mm. ; width of base 35 to 50
mm.; thickness 15 to 25 mm., and
weighing about 15 to 20 grammes.
Its position is 5 to 15 mm. below the
symphysis pubis, 25 to 40 mm. from
the anus; it surrounds the posterior
urethra and bladder neck.
It is held in place by the pubo-
prostatic ligaments and anterior fibers
of the levator ani muscles. Be-
tween the prostate and rectunii is a
quantity of loose fascia and the pros-
tatic plexus of veins. Normally the
prostate is in two lateral lobes, sepa-
rated by a depression or fissure which
is readily detected with the examining
finger; additional lobes, bars or irregu-
larities are the result of changes com-
ing through age, disease or injury.
The prostate is enveloped in a dense
fibrous capsule, reflections of which are
diverted into the substance of the organ
The vacuum glands found here
present columnar epithelium. They
are surrounded by muscular tissue and
empty into the prostatic urethra
through a prostatic duct.
About the office of the prostate
there has been much conjecture,
though today it is generally conceded
to be purely a sexual organ, and that
any other function it may possess is
secondary. Many claim that the pros-
tate by encircling the bladder neck acts
as a sphincter muscle, but later re-
search does not bear out such a view.
The prostatic urethra extends the en-
tire length of the organ ; it is roomy,
and within it is much that is interest-
ing; here we find the ducts of the
glands that enter into its make-up,
here the opening of the ejaculatory
ducts, the verumontanum and sinus
pecularis.
Physiology of the Prostate. —
Through its muscular endowment the
prostate controls the ejaculatory ducts,
and in this way the seminal fluid is
taken from the vesicles into the pros-
tatic urethra, where it is mixed with
the prostatic secretion. Through its
muscuko^ natm^ this fluid is com-
pressed sufficiently to Bend it with tell-
ing effect into the vagina and i^imst
the cervix to develop at the critical
moment in the female sexual satis-
faction.
Within the mucous membrane of
the prostate are found a systens of
nerves, the behavior of which is an
unsolved problem; disturbances here
often give rise to that mysterious and
puzzling condition recognized as
sexual neurasthenia, the remedy of
which is making peace with this part.
The glandular feature of the prostate
performs a distinct and important
function. The secretion is a thin
opaque, alkaline material, with strong
spermatic odor. The recognized use
of which, is a diluent and antiseptic
for the sp^matic fluid that offers food
and protection to the spermatoza.
Thus it will be seen that the prostate
is not only a sexual organ, but one
that is absolutely indispensable, that
without it the race would end and
without it the pleasure of sexual con-
tact would be wanting.
Pathology of Prostatic Hypertrophy.
— There is so little known of the
pathogenesis of this condition that this
part of the subject might well be
passed, and we are by no means of one
accord upon what little that is known.
That it is a chronic non-inflammatory
hyperplasia, affecting both its glandu-
lar and muscular composition, most of
us are ready to admit. Arterio-
sclerosis has been advanced and de-
fended by Guyon and Lannois, and as
ably denied and disputed by Casper,
Motz and others. The analogy be-
tween the uterus and the prostate and
the fibromyoma theory of Thompson
and Velpeau has faded under the light
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Original Contributions.
irch, for pathologists
deno-fibroma.
congestion theory is
ot be supported by
White and Martin has
sorters, and the author
impressed with it, but
that neither this nor
lus far taken adds
imited knowledge or
on the subject gen-
prostatic hypertrophy
riations in size, shape
this body. All parts
take on this hyper-
ime time and in the ,
imining macroscopic-
lien it is removed, we
al conclusions. Many
inequal size and shape
;he gland is incised.
Ft and hard. In fact,
such an arrangement,
ere a trace of normal-.
Very often the re-
pears even more com-
microscopic examina-
iderable that is patho-
lust bear in mind that
n subject to long and
r to its removal ; that
static hypertrophy be-
y conditions in neigh-
ich often are reflected
concretions are fre-
ind ulcerations follow,
ell the necessity for
md how reckless and
ions usually are that
ion.
w of all the facts at-
ondition, we may be
present at least, with
ing, and that our lim-
upon certain features
ertrophy should only
iterest in the more
practical directions.
Prostatic hypertrophy is at all times
easy of diagnosis. The means and
instruments for this alone are ever at
hand. To accurately measure the^
overgrowth or to determine its precise
configuration, while interesting from a.
scientific standpoint, requires special
instruments and skill, but not always
at the command of the general phy-
sician.
The damage being done by an en-
larged prostate is by no means deter-
mined by its size. The author has-
very often seen enormous glands that
were producing but little disturbance,
and the other extreme as well. This-
condition is often best estimated by
its consequence rather than by its size-
or shape.
The advice that we are called upon
to render in this situation carries with
it weighty responsibility. We must
call to our rescue here our character
and professional strength, and remem-
ber all the conditions, under which we
are to proceed.
The answers to the questions that I
now invite your attention fully cover
the subject in its entirety, and I am
safe in here promising you satisfactory
returns for your pains.
JOHN A. WTETH; M. D..
or NEW YORK.
( 1 ) Sedentary pursuits tend to pros-
tatic hypertrophy. Active out-of-door
life promotes normal secretion and ex-
cretion and assures nourishment of the-
tissues in general.
(2) The phlegmatic and nervous-
suffer about equally if they follow
sedentary pursuits and are troubled
from indigestion and uric and oxalic
acid diathesis.
( 3 ) Prolonged irritation of the blad*
der from any cause, together with irri-
tation of the vascular system which is
produced by a chronic uric acid and ox-
alic acid diatheses, and excessive use of
the prostatic muscle are the chief
causes of prostatic hypertrophy.
(4) Have never needed the cysto-
scope in diagnosis, nor is any instru-
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Prostatic Hypertrophy,
Q7
ment necessary. The symptoms, to-
gether with a digital examination,
make the diagnosis easy.
(5) Alcohol in any form is a factor
in arterial irritation, and is also a fac-
tor in prostatic hypertrophy. Consti-
pation is also a factor.
(6) In cases where operation for
^ny reason is more than ordinarily
•dangerous the catheter life may be ad-
vised. Especially true in the very aged,
seventy and over.
(7) Have not practiced ligation of
the vasa deferentia, and do not see any
indication for this operation.
(8) Have practiced this operation
{castration) once with regret. Pa-
tient recovered but was not improved.
(9) Do not believe in Bottini's op-
eration and have never practiced it.
(10) No answer.
(11, 12 and 13) Have practiced su-
pra-pubic prostatectomy and perineal
prostatectomy, but was not satisfied
with either procedure as compared to
a combination of both of these opera-
tions, which, in my opinion, is far pref-
erable to the one or the other for
these reasons : Supra-pubic • incision
into the bladder is a simple operation
and does not add materially to the
risk of a perineal incision. With the
two incisions a dissection can be made
rapidly and intelligently between the
index finger of each hand. The drain-
age through the perineal wound secures
a quick closure of the upper wound.
The supra-pubic wound gives a better
exploration and command of the blad-
der than the lower incision. No com-
plications have arisen during or after
any of my cases. I have had no
deaths following prostatectomy, but
have operated only in comparatively
few cases. My opinion is that the op-
eration is a valuable one. It should
be performed early in the history of a
case of prostatic hypertrophy. If the
bladder becomes greatly overdistended
or loses the power of emptying itself,
and if it is nursed into helplessness by
the use of the catheter, it is difficult to
overcome this even after the obstruc-
tion has been removed.
(14) None.
(A) No answer.
♦ ♦
*
AUaUBTUS 0HARLB8 BEBNAT8. X. D..
OF «T. LOUIS.
(1) The statistics I have seen do
not decide this question. I have an
idea that these factors play but a very
insignificant part. See next answer.
(2) Do not think these are pertinent
questions ; do not go much on home-
opathic or temperamental pathology.
(3) Etiology. — This is a short sum-
mary of what is known at present about
etiology. The question of how much
clap and stricture contribute to the
cause of prostatic hypertrophy is not
yet solved.
Up to the present time the etiology
of prostatic hypertrophy has not been
cleared up. A completely satisfactory
explanation of the process has not been
found. Sir Henry Thompson defined
it as an ^'idioplastic tumor" in his
lectures, which I had the great pleas-
ure of hearing. Enlargements of or-
gans during the early and middle life
partake largely of an inflammatory
nature or are found to be small cell in-
filtrations. Knowing that old age
somewhat inclines toward or favors the
development of tumors, we are not
surprised to find that a part of the sex-
ual system may show a non-inflamma-
tory enlargement at a time when this
system, in all its other organs and in
its functions, is undergoing a retro-
grade metamorphosis and is being more
or less put to rest. However, let us
remember that Sir Henry's definition
is not explanatory in any sense and
leaves the etiology of our subject in
the dark.
Reginald Harrison seems to think
that the hypertrophy is caused by
overexertion or overwork of the organ
the function of which he conceives to
be that of aiding the bladder in the
evacuation of its contents. He thinks
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08 Original Contributions.
that the main purpose of the prostate (7) No. I consider it a practice
is to furnish a muscular support ^*pri- based on false premises. I do not
marily to th« bladder and its contents know of a case that was cured. Have
and secondarily to the adjacent parts," treated a dozen or more which were
and thus seems to regard enlarged Castrated by others and were not per-
prostate as a form of compensatory manently benefited,
similar in its etiology to (8^ No.
erstood hypertrophies of (9)1 was called to make a perineal
walls of the heart. Guy- section in one case where infiltration
3 opposed to this view, he of urine and sloughing of the scrotum
e hypertrophy as due to followed a Bottini operation. Have
lis of the urogenital tract, never done Bottini myself.
568 with Velpeau that in (10) The following table gives the
re have an analogue of the results of my supra-pubic drainage
)us uterus. Sir Henry work and the fate of the patients so
30 favors this view, and I far as known to me:
at the myoma of the pros- Cm-ed 1
:ou8 to myoma uteri, and Leading a catheter life, as "before
It may be referred to de- drainage ........ 8
or congenital cell-nests Operated on after Bottini and im-
mant in early life and are proved 2
to late enlargement by Operated on* after *Bo'ttini and "not
accompanying the func- benefited 1
gemto-urinary. organs m Operated on after Bottini and died
disease. ^^ ^l^e third day after the cau-
lust admit that the etiol- ^ ^f ^^ ^j^ pyelonephritis . 1
;atic enlargement is not Operated on by perineal prostatec-
id that the speculations tomy ... . . . 2
ve before mentioned are of thes"e one died of 'pyelonephril
more respectable than tis on the fourth day after op-
itions which bring diet, eration, the other seems to be
lodes of living, abstinence cured.
ce, sexual habits, gout, One patient is now being drained
)r gonorrhea into direct supra-pubically for the second
lological relation with the ^j^^ ... 1
. V. , , Died of pyelonephritis, senile gan-
the diseases in which the g^ene or pneumonia .... 6
)t cleared up the patho - Disappeared and condition unknown 4
3omplete.
few cases where I have Total 26
an expert use the cysto-
lot add materially to our All of those whom I drained supra-
' the intravesical condi- pubically were eloquent in their praises
of the relief afforded to them. The
swer to question 1. The patient who died of embolus was en-
)od here. tirely relieved of his usual trouble and
vast majority of cases suffering before he died, and I am not
*' will have to answer for sure that this death ought to count for
easure until a radical op- much against the supra-pubic opera-
perfected that its dangers tion. I regard the supra-pubic drain-
to a figure much lower age as the best method of giving tern-
t. porary relief to those patients who are
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not willing or not in condition to
undergo prostatectomy* The cystitis
can be cnred by drainage and will not
always return after the drain-hole is
closed.
(11) Once, in an old man (eighty-
one years) at St. Mary's Hospital, died
the next day — think he bled to death.
(12) Twice. Both cases were bene-
fited ; one seems almost cured of his
troubles, if I mfty use this expression.
(13) Ferguson's or Bryson's opera-
tion, which are really very similar to
each other in actual practice.
(14) If you mean prostatectomy, I
can say that I had no trouble in my
two cases.
(A) See above.
BUaBNB FUUjBR. X. D.,
OF NEW YORK CITY.
( 1 ) I do not feel convinced that any
occupation in particular predisposes to
prostatic senile hypertrophy. Those
who have led very active lives, as far
as I can clinically observe, suffer about
equally with those of sedentary habits.
Neither do I think that an antecedent
history of gonorrhoea can be reckoned
as an etiological factor. We do not as
yet know the etiology of this disease.
(2) I do not think that any of the
above enumerated conditions exercise
any causative effect. I have observed
many clinical cases under each of
these subdivisions.
(3) I do not know further than that
certain races seem to be exempt, as for
instance Chinese and Japanese. I have
seen one case, and only one, in a full-
blooded negro.
(4) The cystoscope in this connec-
tion is only of secondary importance.
If there are projecting intravesical
h3rpertrophies they can be seen through
its employment. Digital feel per
rectum and instrumental examinations
per urethra of the prostatic portion of
the canal by searcher and by silk-
woven catheter, constitute the usual
instrument means of diagnosis.
(5) I do not know that habit is re-
sponsible. Prostatic hypertrophy in
many instances is of itself a sufficient
cause for constipation. If one has
prostatic obstruction, that obstruction
may be increased by the taking of al-
coholics.
(6) I advise palliative treatment as
a poor substitute for radical treatment,
chiefly in cases where the individuals
are so frightened at the suggestion of
operative relief that I feel that there
is no use discussing the matter until,
perhaps, the suffering due to the ad-
vancement of the disease has made the
patient amenable to argument. Palli-
ative treatment practically consists of
resort to the catheter.
(7) No, but have watched results in
the cases of others. Saw one case
wherein some relief in symptoms re-
sulted.
(8) Yes, once. Patient died five
weeks after of acute mania, the pros-
tatic obstructive symptoms persisting
up to death.
(9) No, I consider the operation
unsurgical. It is more dangerous
than prostatectomy at my hands ; it is
uncertain in its results; many of the
cases wherein cures have been claimed
for it have relapsed after a year or so
from the date of operation. In any
event it is only applicable to a few se-
lected cases out of many.
(10) Supra-pubic drainage, the pros-
tatic condition being left in ^^statu
quoj^' I consider very inefficient and
half-way surgery. When I open the
bladder supra-pubically I always re-
move the prostatic obstruction except
in case of cancer.
(11) Considerably over 100 times
my results are radical, permanent and
excellent. My mortality, formerly
larger, has for the last year been be-
low five per cent.
(12) Somewhat under 100 times my
results are radical, permanent and ex-
cellent. My mortality has for the last
year by this operation been under five
per cent. I use the median incision.
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(13)1 study each individual case and
make' my choice of operation depend
on the condition of the vesical walls
and on the size and extent and con-
sistency of the prostatic hypertrophy.
I choose perineal prostatectomy instead
of supra-pubic, where nothing special
exists to contraindicate that form of
operation.
(14) There are numerous complica-
tions to guard against in these old sub-
jects. The more accustomed the sur-
geon is to this form of surgery, and
the more alert he is, the fewer com-
plications he will have in his practice.
(A) In my book on ''Diseases of
the Genito-Urinary System," and in
the numerous articles I have written
on the subject, one will be able, if xle-
sirous, of getting familiar with my
ideas in the subject.
* »
*
BDWABD KABTIN. M. D..
OF PUILADKLPHIA, PA.
( 1 ) To no extent.
(2) Obese, but it often makes them
lean.
(3) Probably chronic tubercular
prostatitis. But I don't know.
(4) 'Very little. Leiter Nitze.
(5) None.
(6) Frequency with residuum, with
or without infection. Symptoms non-
crippling, non-progressive; purely lo-
cal. Forced dilatation of internal ves-
ical sphincter under nitrous oxide ; in-
termittent catheterization.
(7) Yes. Four. Cure, one; bet-
terment, one; negative, two.
(8) Yes, once. Cure.
(i») Four. Negative in all; no com-
plications.
(10) About half a dozen cures; ex-
cellent palliative at times.
(11) N'o answer.
(12) Six times; good results in all.
Inverted U with base in perineum.
(13) Perineal, as a rule. After-
treatment simpler and safer.
(14) Severe bleeding, tearing of
rectum; great difficulty in removing
prostate ; friable and adherent capsule^
anuria and uraemia.
(A) Palliative, except when ob-
structive. Symptoms are progressive.
Continuous catheterization for acute
vesical infection; overstretching for
obstruction associated with small pros-
tate; galvano-cautery for the same
condition should overstretching fail.
X-ray and cystoscope for stone in all
cases characterized by great pain and
obstinate cystitis. Prostatectomy by
perineal route as a rule.
* *
»
B&AN8FO&D LBWI8. X. D..
OF ST. I4OUI8.
(1) Sedentary life favors it.
(2) The obese.
(3) Subacute chronic congestion or
inflammation.
(4) Is of considerable service in de-
termining the conformation of pros-
tatic outgrowth. The Bransford Lewis
cystoscope, with prism-telescope, en-
abling the observer to look slightly
backward as well as at right-angle.
(6) All influences contributing to
prostatic congestion or inflammation
favor development of prostatic hyper-
trophy ; hence alcohol and constipation
contribute their quota.
(6) Cases in which not much resid-
ual urine, and infection absent; in
which an operative treatment would be
dangerous on account of accompanying
conditions or diseases. Regular cath-
eterism and vesical irrigation ; internal
antiseptics.
( 7 ) Yes, three cases ; no permanent
benefit.
(8) Yes, twice; no benefit.
(9) Yes, about eighteen times ; suc-
cess in some cases, failure in others,
intermediate results in others; the re-
sults dependent mainly on the confor-
mation of prostatic obstruction pres-
ent.
To illustrate my position, I wish to
call attention to a few points in the
histories of several cases with which I
have been personally acquainted.
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Prostatic Hypertrophy.
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V. S., eet. sixty-five years, came to
my clinic in October, 1901, suffering
from various effects of prostatic ob-
struction, chief among which was com-
plete and absolute inability to urinate
voluntarily, and this, notwithstanding
the fact that perineal prostatectomy
had been done on him six months be-
fore (on June G, 1901) by an acknowl-
edged authority in this mode of oper-
ating. The complete retention, re-
lieved only by the regular passage of
the catheter, had existed, the patient
said, from the time of the withdrawal
of the perineal drainage tube, seven
days after the operation. A perineal
fistula still existed, from the same pro-
cedure.
Here was a case of complete failure
of relief after removal of the prostate
by an opei'ator whose ability and ex-
perience cannot be put into question.
My cystoscopic examination seemed
to reveal a projection from the poste-
rior commissure, hanging somewhat
into the bladder. With a doubt in my
mind as to its probable efficacy in the
case, which doubt I expressed to the
class before whom I operated, on No-
vember 20, 1901, 1 made one posterior
incision, three centimeters in length,
with the Freudenberg incisor. Be-
cause of the absence of prostatic tis-
sue, on account of the previous oper-
ation, it was evident that care must be
observed not to bum into perineal
structures. No hemorrhage resulted ;
cocaine anesthesia, secured with my
urethral tablet-depositor, was so com-
plete that the patient declared that
there was no more pain than there was
from an ordinary catheterism. He re-
mained in the hospital three or four
days, and was then about, as usual.
Besult, possibility of voluntary urina-
tion, and reduction of the complete re-
tention to seven ounces of residual
urine* One month later, the same op-
eration was repeated, with no more
trouble to the patient ; and the net re-
salt was a further reduction of the re-
sidual urine to about four ounces, to-
2
gether with increased freedom in vol-
untary urination. This not being sat-
isfactory to me — although a marked
improvement over his condition for the
previous five or six years— it seemed
advisable to open supra-pubically,
which I did before the class on Janu-
ary 8, 1902. A collarette of fibro-
mucoid tissue completely surrounded
the urethral orifice, and in just the po-
sition to fall together in a valvular
manner and shut off the egress of urine
when attempts at voluntary urination
were made. The more marked the
contraction, the tighter would the valve
be closed. My posterior cautery incis-
ion was there, as shown in the model,
but it had only bisected the posterior
segment of the collar, the flaps of
which could still fall together and in-
terfere markedly with the outflow of
urine — although the groove thus made
would probably allow of the leakage
through it of a part of the urine. This
accounted for the improvement noted
after each of the electro-incisions (re-
duction in the residual urine at first to
seven, then to four ounces); and also
for the failure of the incision to give
complete relief to the case.
Through the supra-pubic opening,
with a Paquelin cautery I burned off
the whole of the projecting mass, ac-
centuating the cauterization on the
posterior aspect, to secure as low a
level as possible; nevertheless a con-
siderable depression was still left in
the bas fond, as I did not wish to open
the prostatic urethra to secure an abso-
lutely '*low level," flush with the bot-
tom of the bas fond. My chief object
was to remove (he obstruction^ which
was done in the manner described.
Nothing was done bearing directly on
the perineal fistula. It was considered
that, with clearing up of the outlet,
this would take care of itself. The
bladder was drained supra-pubically
for eight days. After the removal of
the tube, and even before the supra-
pubic wound was closed, the bladder
was able to expel in a good stream
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102
Original Contributions.
through the urethra a part of the urine
or the irrigation fluid. Since the clos-
ure of the wound, he has urinated
properly and regularly, in what he es-
teems a very delightful stream. He
can irrigate his bladder without the aid
of the catheter; in fact, the catheter
is now never used except for the pur-
pose of testing the amount of residual
urine, which has been reduced to one-
half or three-fourths of an ounce. The
frequency of urination is about normal
(six or seven times in twenty-four
hours). The patient has been able to
resume his occupation of carpentering
after an interruption of one year. He
relates that previous to the prostatect-
omy, he had been forced to use the
catheter regularly for nearly eight
years, carrying it in his pocket for that
purpose (from March, 1894, to Novem-
ber, 1901).
Case 2. — W. D. set. sixty-five years,
was turned over to my care at the City
Hospital, by my friend, Dr. Nietert,
who, with his internes at that time, is
familiar with the subsequent develop-
ments.
The patient had suffered from trou-
bles connected with urination for four
or five years previously. His general
health and strength were markedly re-
duced, so that he was very feeble,
looking much older than he really was.
He was passing urine about thirty-five
times in twenty-four hours, as often at
night as in the day time, harassing
him with loss of sleep as well as much
actual suffering. His urine was of
light straw color, low specific gravity
(1.010), and contained albumin and
casts, indicative of involvement of the
kidneys. Cystitis was present. Re-
sidual urine was about twenty-eight
ounces. A metal catheter of ordinary
curve was obstructed, while one of
long prostatic curve went in easily.
Because of the enfeebled condition of
the patient, and the renal complication
mentioned, a more radical operation
than the Bottini was deemed danger-
ous; and it was considered necessary
to undertake even that with the utmost
caution. The Bottini was done on
January 27, 1898, under cocaine anes-
thesia, onlv one (posterior) incision
being made in order to avoid severity
as much as possible. It was ten days
afterwards before noticeable improve-
ment began, but it was progressive
thereafter, so that in a month he was
urinating freely and in a good stream ;
and instead of thirty-five times in the
twenty-four hours, it was only seven
or eight times. The residuum had
been reduced to about two ounces.
The patient's general and renal condi-
tions had both improved materially.
I was desirous of showing him at the
medical society, to which he consented,
with the request, however, that we wait
until he could be operated on for a
large inguinal hernia, of which he was
the bearer. We waited. He was
turned over to another consulting sur-
geon who operated for the hernia.
The wound became infected, resulting
in gangrene there and also in the intes-
tines and lungs. His death soon after
enabled me to get a good specimen.
As is usual after maceration in alco-
hol, the tissues have shrunk some-
what, so that they do not appear ex-
actly as they did when fresh ; but the
moderate enlargement of the prostate
is evident, likewise the groove posteri-
orly and tq the right, made by tho in-
cisor.
The depth of this groove is only ev-
ident when we oppose the parts as they
were seen before the incision was
made, when the narrowing of the out-
let is seen to be marked.
Dr. Willard Bartlett, who made the
post-mortem examination, made the
following annotation regarding it:
"The prostate shows both lateral lobes
hypertrophied. The wound left by
what the clinical history terms 'Bot-
tini's operation,' is completely healed,
leaving an orifice to the right of the
median line which will easily admit an
ordinary lead pencil into the prostatic
urethra, and evidently furnished a free
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Prostatic Hypertrophy.
108
outlet for the urine." The obstruct-
ive condition in this case was a bar
formation at the posterior commissure ;
the incision had severed it and opened
a groove through which the urine
could pass with only slight impediment.
(10) Practiced it only for the tem-
porary benefit it affords, which is often
very valuable, permitting recuperation
for a raore.effective operation.
(11) Three times; good result in
each case.
(12) Eight times; excellent success.
The inverted Y incision is preferable.
(13) Each operation, in selected
cases; but with other things favora-
ble, the perineal prostatectomy gives
most secure results.
(14) In one case, in which linear
perineal incision did not give sufficient
space, a small tear was made through
the anal margin, and a constipated
movement of the bowels two days later
enlarged it for an inch into the anterior
rectal wall. The perineal wound heal-
ing, left a urethro-rectal fistula, which
I healed by an extensive plastic opera-
tion.
(A) Summing up the points favor-
able to the three operative procedures
especially considerea in this discussion,
we have ;
Favorable for the Supra-Pubic
Route. — (a) General enlargement of
the prostate, with extreme intra-vesi-
cal projection of the median or lateral
lobes, diminishing their accessibility
from the perineum. (6) Marked ped-
unculation of the intra-vesical tumors,
with absence of obstruction from other
sources.
Favorable for the Perineal Route. —
(a) General hypertrophy, involving
the median and lateral lobes, without
■extreme intra-vesical projection. (6)
Large or very thick bar formation;
marked compression of the urethra be-
tween the enlarged lateral lobes, (c)
Excessive development of the prostate
in the direction of the rectum, (rf)
In most cases, where the patient is in
good general condition and there is not
a special indication favoring one of the
other procedures.
Favorable for the Bottini. — (a)
Cases of extreme debility, unable to
stand one of the severer operations.
(6) Cases of bar or medium sessile ob-
struction, of not too great dimensions.
(c) Incomplete collar formation, (d)
Horwitz says it should be employed as
a prophylatic against further obstruct-
ive hypertrophy, at the beginning of
catheter-life.
J. B. MUBPHT. M. D.
or CHIOAQO.
(I) I have not been able to discern
that occupation plays any part what-
ever in the production of prostatic hy-
pertrophy.
(2^ About equal.
(3) I am unable to determine, from
my experience, any etiologic factor in
the production of prostatic hypertro-
phy. I believe those given in the text-
books are erroneous and the result of
imagination rather than the close ob-
servance of facts.
(4) The cystoscope has been of no
service.
(b) None.
(6) I advise palliation in cases of
temporary obstruction for urinary re-
tention. Consists of use of hot baths,
large quantities of distilled water,
opium and belladonna suppositories,
avoidance of catheter or bladder irri-
gation.
(7) No.
(8) Yes. With pronounced effect
in two cases and no effect in the re-
maining.
(9) No. I have not performed the
Bottini.
(10) I practiced supra-pubic drain-
age for ten years, in a large number of
cases, at the Alexian Brothers' Hos-
pital. The results were very unsatis-
factory, for two reasons: first, they
were not resorted to until the cases
were extreme; second, I believe it is
not an efficient treatment.
(II) Probably fifteen or twenty
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104
Original Contributions.
times, with very unsatisfactory re-
sults. My Alexian Brothers* Hospital
records are not at my disposal at the
present time, and, therefore, I cannot
give the exact number.
(12) Twenty-nine times, with per-
fect success. The crescent or "A"
shaped incision gives the best space.
(13) The perineal operation, as de-
scribed in the Jouimal of the Ameri-
can Medical Association about one
year ago.
(14) None during operation. I
have been impressed by the care that
must be exercised to avoid the rectum,
with very large prostates.
Post-operative complications. — One
case, apoplexy two weeks after opera-
tion ; patient was sitting up reading
newspaper. In another there occurred
a peri- and endo-carditis, rheumatic,
five weeks after operation, when the
patient was practically well and about
to go home.
(A^ I believe that the operation of
the future will be prostatectomy by
the perineal route, **A" shaped incis-
ion, removal of prostate from the
bladder wall from above downward,
with remov^al of the floor of prostatic
urethra ; that it should be resorted to
early, before the manifestations of
sepsis ; that prostates of any size may
be removed through the perineum;
that drainage of the bladder is not
necessary for longer than two weeks ;
that with experience and care the
operation can be performed safely
within thirty minutes ; that the ''A"
shaped incision allows as much space
for the removal of the prostate as the
vagina for the removal of the uterus ;
that the result is a practical restora-
tion of the normal conditions of the
bladder; that there is permanent disa-
bility for intercourse.
*
OBVILLB HOBWITZ. M. D..
OF PHILAOSLPHIA, FINN.
(1) So far as I have been enabled
to ascertain — none.
(2) There seems to be little or no
difference. The condition is rarely
found in the negro.
(3) Not ascertained.
(4) The cystoscope is of much value
in portraying the condition of the
bladder and greatly aids the surgeon
in determining the expediency of per-
forming a Bottini operation, or a pros-
tatectomy.
The condition of the bladder enables
the operator to decide whether or not
a radical operation will be followed by
relief of the annoying vesical symp-
toms.
The most satisfactory instruments
that have been employed by the writer
for diagnostic purposes is the posterior
urethroscope of Swinburn and the
Bransford Lewis cystoscope.
(5) The habits of individuals do not
appear in any way to tend to the
formation of hypertrophy of the pros-
tate gland. Constipation is frequently
an annoying accompaniment associated
with it; it seems to be caused by the
enlargement of the gland, as the radi-
cal operation is often followed by its
disappearance. This has been espe-
cially noticed to take place after the
Bottini operation.
(6) Palliative treatment is reserved
for those cases who are advanced in
years in whom the obstruction has ex-
isted for a long period of time and ex-
hausted from pain, suffering and
loss of sleep. In old men whose re-
sisting power is at a low ebb, where
the bladder is hopelessly damaged, and
in those who show marked signs of
general sclerosis; as rigid . vessels,
arcus senilis, polyuria, hyaline casts or
pyelitis.
The treatment advocated in this class
of cases depends on the physical con-
dition of the patient, the character of
the prostatic overgrowth, the state of
the bladder and kidneys. It may be
summarized as medical; hygienic;
systematic catheterism; rest in bed
for several weeks, the bladder drained
by means of continuous catheterism ;
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Prostatic Hypertrophy.
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irrigation of the bladder with appro-
priate sulutions, or instillations of
various remedies; rectal injections;
permanent drainage by means of a
supra-pubic cystotomy; in some in-
stances a Bottini operation in con-
junction with periodical catheterism.
In patients who suffer from recurring
attacks of orchitis from the passage of
a catheter, vasectomy is performed.
(7) Twenty-eight individuals were
submitted to this operation, all of
whom, with the exception of six, were
over sixty-three years of age, and the
sexual functions of all but six were in
abeyance. Vasectomy was performed
whether the enlargement of the pros-
tate was glandular or fibrous in char-
acter. No deaths resulted from the
operation. . The results obtained lead
me to the following conclusions:
(a) As a curative measure vasectomy
is of little value, and is not to be
recommended.
( b ) The operation appears to be most
effective when performed on patients
between fifty and sixty years of age,
in whom the prostatic enlargement is
of the soft glandular variety. The
genitnl organs of patients of this age
are usually in a healthy condition, and
the individuals usually object to any
operation that is liable to interfere
with their sexual functions.
(c) The operation is serviceable in
those cases where the physical condi-
tion of the individual renders him unfit
to undergo surgical procedure, who
will not submit to a more serious pro-
ceeding, who has to depend upon the
frequent use of the catheter or who
suffers from periodical attacks of
orchitis.
(d) Sexual vigor is not diminished
by the division of the vasa deferentia.
(e) Atrophy of the testicle does not
result from the operation.
(8) In forty-four cases bilateral
orchidectomy was performed, irre-
spective of the character of the en-
largement of the prostate gland. All
the patients were men in advanced
years, whose sexual powers had dis-
appeared; in the majority the heart
was feeble, the arteries atheromatous,
and they all suffered from general de-
bility, the result of the wear and tear
of prblonged misery. In a few, a far-
advanced diseased condition of the
bladder and kidney existed. Several
had suffered from frequent attacks of
retention of urine; catheterism was
necessary in all ; the insertion of the
instrument was difficult and painful.
In this class of patients prolonged
anesthesia, with any seribus operation
in addition, would in all probability
prove immediately fatal.
(a) In selected cases, bilateral cas-
tration will always hold a place in
genito-urinary surgery as a means of
removing the obstruction caused by
prostatic hypertrophy.
(6) The operation is indicated in men
of advanced years, whose sexual pow-
ers are lost, the overgrowth of the
prostate being purely glandular in
character; or who have reached that
period of life where the passage of a
catheter becomes difficult and reten-
tion of urine not an uncommon occur-
rence; or an advanced diseased condi-
tion of the bladder and kidneys does
not preclude a serious operation.
(c) When the prostatic enlargement
is fibrous in character no benefit is de-
rived from the operation, and its em-
ployment under these circumstances is
not to be recommended.
(d) The primary effect of castration
on the glandular prostatic hypertrophy
is first to relieve congestion, and
secondarily to cause atrophy.
(e) When the prostatic enlargement
is fibrous in character no benefit is de-
rived from the operation and its em-
ployment under these circumstances is
not to be recommended.
( /) Orchidectomy in very old sub-
jects with extensive disease of the
bladder and kidney is attended by a
large mortality, and is a very serious
operation.
(9) Seventy-nine patients, between
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106
Original Contributions.
the ages of forty-nine and eighty-one
years, were operated on by me by the
**Bottini method." One death re-
sulted. According to Dr. Fredenberg
(Berlin), the most recent statistics
show that good results can be looked
for in 86.63 per cent, of cases; failure
in 7.6 per cent.; mortality in 4.5 per
cent.
For convenience of description the
cases that I have treated may be di-
vided into three groups :
First. — Comprising individuals who
were commencing to suffer from the
effects of prostatic obstruction, and
who required the daily use of the
catheter. These were between the
ages of forty-nine and sixty-one.
Heretofore this class of patients would
have been placed upon what is known
as the ''Palliative Method of Treat-
ment." Of sixteen who submitted to
the operation before the secondary
pathological changes that follow pros-
tatic hypertrophy had taken place, all
made prompt recovery ; the period of
convalescence varied from four to
eighteen days. When operating on
patients at the beginning of prostatic
hypertrophy, the gland as a general
rule being but slightly enlarged, a pros-
tatic incision with a smaller blade
should be employed than that which is
used in more advanced cases. The
Bottini operation performed early may
be regarded as a radical method of
treatment resulting most favorably.
It would seem as though the time had
passed when the physician is satisfied
to advise his patient to use the catheter
daily and patiently wait until the ob-
struction becomes so great and the
complications so grave that some rad-
ical surgical procedure is necessary to
give relief.
Second. — The second group of cases
comprises those where the obstructive
symptoms have existed for a length-
ened time, where the bladder is begin-
ning to be involved, and is in the proc-
essof undergoing pathological changes.
Catheterism is daily requisite, the
physique of the individual being still
in good condition. This group is
portrayed by eight operations, the in-
dividuals being between fifty-nine and
sixty-three years of age ; the period of
convalescence, including necessary
after-treatment, was from two weeks
to four months. Of the number op-
erated upon five were cured, two were
improved, and one was benefited, so
far as residual urine was concerned,
which was owing to the bladder being
atonied and paralyzed; the catheter
was readily inserted, the prostatic
spasm having been entirely relieved by
the operation. A slight amount of
cystitis continued with a persistence of
residual urine, rendering the use of
the catheter necessary.
To the third group belonged men
more advanced in years, their ages
ranging between sixty-five and eighty-
one years, in whom prostatic hyper-
trophy had existed for a lengthened
period, who had reached what is known
as the *'Break-diOwn of Catheter Life,"
whose general health was below par,
with atheromatous degeneration of the
blood vessels, and polyuria, together
with damaged bladder and kidneys,
and who had suffered from repeated
attacl^s of retention of urine. A large
amount of residual urine existed in
each instance. All were in too poor a
condition to withstand a capital opera-
tion, and before the introduction of
Bottini 's method would have had to rest
satisfied with some. palliative procedure.
Out of the number of patients op-
erated upon, in three there was a slight
tendency to the recurrence of the ob-
structive symptoms at the end of six
months, making a second operation
necessary. Two had occasional attacks
of congestion of the prostate gland,
associated with temporary retention of
urine, following prolonged dissipation
and exposure. From the results ob-
tained by the experience that I have
here recorded, I feel that I am war-
ranted in forming the conclusions here
set forth :
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Prostatic Hypertrophy.
107
(a) Success following the Bottini op-
eration depends on having perfect in-
struments, a good battery, the neces-
sary skill, and the employment of a
proper technique.
(6) In suitable cases the Bottini is
the safest and best radical operation
thus far advised for the relief of pros-
tatic hypertrophy.
(c) It is often very efficacious in ad-
vanced cases of obstruction as a palli-
ative measure, rendering catheterism
easy and painless, relieving spasm,
lessening the tendency to constipation,
and improving the general health.
(d) It is of especial service in the be-
ginning of obstructive symptoms due
to hypertrophy of the prostate gland,
and may be regarded as a means of
preventing catheter life.
(e) It is indicated in all forms of
hypertrophy except where there is a
valvular formation, or where there is
an enormous overgrowth of the three
lobes associated with tumor formation
giving rise to a pouch, both above and
below the prostate gland, in cases of
a massive enlargement of the lateral
lobes or when intra-urethral growths
exist.
(/) Where the bladder is hopelessly
damaged, together wilh a general
atheromatous condition of the blood
vessels, associated with polyuria, re-
sults are negative.
{g) Pyelitis is not a contra-indication
to a resort to the operation.
(10) Have practiced suprapubic
drainage in seventy-six cases. It is
doubtless the most satisfactory pallia-
tive operation that can be resorted to.
Mortality about 2 per cent.
(11) Have practiced suprapubic
prostatectomy in fifteen cases; three
deaths. Results excellent.
(12) Have performed perineal pros-
tatectomy in thirty-one cases. Results :
Fourteen cured ; seven much improved ;
four slight benefit; one unimproved ;
five deaths. Used median incision.
Bryson's technique ; perineal prostatec-
tomy gives lower mortality, less hem-
orrhage, with better drainage; no in-
jury to the neck of the bladder. A
shorter time is required to perform the
operation. Ninety-five per cent, of
hypertrophy of the prostate gland can
be removed by means of a perineal in-
cision. The writer recently removed a
gland weighing an half a pound by
means of the median cut.
(13) A suprapubic prostatectomy
is a chosen operation in cases of ob-
struction, due to valve formation, with
along-standing cystitis; as it is like-
wise where obstruction is due to a col-
larette, when a partial resection of the
gland may be performed.
Prostatectomy should be performed
only in cases that have been carefully
selected. Many are fit only for pallia-
tive operations. In many instances it
is wise to perform a preliminary supra-
pubic cystotomy, drain the bladder
for some time until the patient's con-
dition will warrant a pro8tatectom3\
(14) No unexpected coniplications
have ever arisen in the practice of the
writer during, or following, the oper-
ation for prostatic hypertrophy. In
two instances recto-urethral fistula
formed on or about the twelfth day ;
owing probably to the employment of
metal drainage ; drainage is now main-
tained by means of a soft rubber rectal
tube, caliber 40 m., after perineal pros-
tatectomy. In one instance secondary
hemorrhage supervened on the second
day. One patient died of secondary
shock twenty-four hours after opera-
tion. A perineal operation fistula re-
sulted in one case, requiring a second
operation.
In several cases dribbling of urine
has followed a perineal prostatectomy,
which condition has lasted from six
months to a year. In one case a tend-
ency to the formation of a urinary
stricture was developed at the neck of
the bladder necessitating the use of
bougies.
(A) xVo ansvjer.
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108
Original Contributions.
WILLIAM K. OTIS. M. D..
OF NBW YORK CITY.
(1) As far as I am aware occupa-
tion has no effect in the production of
prostatic hypertrophy.
(2) It occurs without reference to
these conditions.
(3) I do not know.
(4) The cystoscope is of considera-
ble value in the diagnosis, in showing
the amount of internal overgrowth
present. The * 'retrospective" cysto-
scope, made for me by Wappler & Co.,
gives a good view of the internal ure-
thral orifice which is of great service
when prostatic hypertrophy is present.
The same is accomplished by Prof.
Young's cystoscope for this purpose.
The ordinary cystoscope is of much
less value.
(5) Not responsible at all.
(6) Prevention of urinary infection,
use of catheter, avoidance of exposure
to cold and wet, care of general health
— avoidance of constipation — uro-
tropin.
(7) Three cases without result.
(8) One case; patient died two
months after operation without im-
provement.
( 9 ) I do not approve of the Bottini
operation. Consider it dangerous in
comparison with results obtained, and
have never performed it.
(10) Four cases; this being only a
palliative operation the annoyance of
the supra-pubic wound, irritation of
the skin and odor are always present
though the patient may be compara-
tively comfortable otherwise.
(11) iV^o answer,
(12) iVb answer.
(13) The perineal operation with
supra-pubic opening down to but not
opening the bladder. The enuclea-
tion taking place through the perineal
opening, the prostate being pushed
down with the hand in the supra-pubic
wound. Gives better drainage and
quicker recovery than any other
method. Most serviceable on thin
subjects.
(14) No answer.
(A) No answer.
ALEXANDBB HUGH FSBaUSON.
OF CHICAGO, ILL.
D..
( 1 ) Nearly all my cases were robust
and led active outdoor life, riding, etc.,
but soon lost flesh and became nervous.
More were physicians than any other
class.
(2) Temperament plays no part.
(3) Infection engrafted on hyper-
emia or traumatism. In all my cases
the tissue changes were inflammatory
in character.
(4) Can make diagnosis without
cystoscope. It punishes a patient to
use it, and the majority of cases cannot
stand it. The clinical history alone is
sufficient on which to base a diagnosis
in the vast majority. The sound and
finger are the instruments most used
by me.
(5) Constipation in 75 per cent.
Alcoholism caused congestion and re-
tention; exposure to cold was often
followed by retention.
(6) (a) Catheterization for reten-
tion.
(6) Aspiration for retention if
catheter cannot be passed.
(c) Perineal section and drainage in
desperate cases too bad for a radical
operation.
(cZ) I have used bougieing to advan-
tage, but it is dangerous.
(e) All these means are only pallia-
tive to prostatectomy. I do not prac-
tice palliation very much.
(7) Yes. About twelve cases. All
but two temporarily benefited. None
cured. I have discarded the procedure.
(8) Yes. Three times. No benefit
permanently ; no result at all in two.
(9) Yes. Three times; one death
(septic). No permanent relief. I
know now that they were not suitable
for Bottini.
(10) Never practiced it. Have re-
moved the pro.state via perineum to
cure supra-pubic fistulse.
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Prostatic Hypertrophy,
lOO
(11) About twenty-four with six
deaths. I have abandoned this opera-
tion.
N. B.— Thought I had about fifty
cases until I began to count them up.
(12) Twenty-nine times ; one death,
the rest cured. The j^ shape gives
most rooip , but greatest traumatism . I
find so much room unnecessary.
(13) Median perineal, (a) It af-
fords ample room', (b) The traumatism
is minimized, (c) Drainage is perfect.
{d) Never applied a ligature on a
vessel.
(14) Opened the peritoneal cavity in
one case between the rectum and blad-
der, with no ill result. Post-operative
i^omplications: (a) Epididymitis in
five cases, mild in character, (b)
Rectal fistulae in two cases, both caused
by careless dressing over a week after
the operation by the man in charge.
One of these cured since by operation.
The other has vesical control.
(A) Supra-pubic prostatectomy, 25
per cent mortality.
Perineal prostatectomy, 3.4 per cent,
mortality.
Bottini prostatectomy, 33J per cent,
mortality. . •
(One out of three).
♦ ♦ ^•
BOBBBT TUTTLB MOBBIS. M. D..
OP NEW YORK CITY.
( 1 ) No definite testimony.
(2) In my particular set of cases
the men have belonged to the lean
and nervous type chiefly.
(3) Presumably a simple degenera-
tive change, similar to that which
occurs in the uterus.
(4) Of service in determining the
nature of some of. the complications
that involve the bladder. I use the
Rochester S. A. cystoscope at present.
(5)1 rather doubt if they have any
bearing.
(6) Palliative treatment for cases
without serious complications, and for
cases with such serious complications
that the comparative danger between
operation and no operation is too great.
Standard methods.
(7) Yes, one case. No result of
consequence.
(8) No.
(9) No.
(10) Several cases in former years.
Now prefer prostatectomy when feas-
ible.
(11) Three cases. Combined op-
eration; satisfactory result.
(12) Three cases; semilunar. All
the patients benefited.
(13) Must depend upon the case.
In cases requiring special draini^e,
combined operation. In others, the
simple perineal operation.
(14) None.
(A) It has been chiefly palliative
until recently.
*
B. XBBBILL BIOXBTTS. M. D..
OP CINCINNATI, OHIO.
(1) Cause unknown. More fre-
quent among civilized races. Occupa-
tion and sedentary habits are probably
the greatest factors in its production.
(2) Have not noticed any differ-
ence.
(3) Don't know.
(4) A great aid where neoplasm is
intravesical.
(5) Have no evidence that they are
a cause, but believe them to be of
more or less influence in its produc-
tion.
(6) Inoperable cases; those who
could not withstand prostatectomy.
(7) Once. No benefit. .
(8) Twelve times. Double orchi-
dectomy. Excellent results in major-
ity of cases. Cure in one seventy-
three years old at end of five years.
See ''Cincinnati Lancet-Clinic," pages
396-688, 1902.
(9) Never approved of the cautery ;
never did it.
(10) Never did it.
(11) Never made one.
(12) Five times. Perfect drainage ;
later median incision.
(13) Perineal prostatectomy.
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Original Contributions.
(14) None.
(A) Have made three prostatec-
tomies, two complete, one. partial.
The two were emergencies in which
vesico-rectal fistula was accomplished.
Patients utilize rectum for urinary
receptacle. See Lancet'CUnic, Octo-
ber 1, 1902, to February 14, 1903.
HOWABD LUiIENTHAL. m. d..
or NEW YORK CITY.
(1) Most of my cases active in-
door, but do not believe that any occu-
pation can be shown to have caused
the trouble, judging from my cases
alone.
(2) The lean and nervous, though
some of my cases were obese and a
number were phlegmatic.
(3) Fibroma and fibromyoma within
the capsule.
(4) In my cases of very little ser-
vice. The observation cystoscope,
with the prism within the angle so as
to look around a corner, has been
used.
(5) But one of my patients used
alcohol to excess; nearly all drank
very moderately. Constipation not a
marked factor.
(6) In diabetics, careful catheteri-
zation with the administration of
urinary antiseptics is advised, unless
there is active and alarming hemor-
rhage, when suprapubic cystotomy is
advised. No prostatic operation.
(7) In only one case, the patient
being very weak. Death from urinary
sepsis, which was already present be-
fore result could be observed. Op-
eration apparently did not hasten fatal
outcome.
(8) Three cases; all with temporary
relief only. One remained well, but
with some ounces of residual urine,
for about six months, when catheter
cystitis supervened. He was not in
New York at the time, and I lost sight
of him. One case developed ptyalism.
(Note connection between parotids
and testes.)
(9) Never.
(10) Temporary im pro vem en t.
Have practiced it many times before
the days of prostatectomy.
*(11) Thirteen times. One death,
from uremia, within twenty-four
hours, patient having been uremic at
time of operation, which was an im-
perative one. All others were cured
so that there was no residual urine.
(12) Never, except partial in one
case in which it became necessary to-
abandon perineal route and attack
from above, because, of large size of
prostate.
(13) Suprapubic without perineal
drainage; better exploration of blad-
der; obliteration of the trigonal pouch
on healing. Traumatism to im-
portant structures less than by peri-
neal. Quicker. My own very satis-
factory results will probably induce
me, in most cases, to continue as I
have done in the past.
(14) None during the operation.
Suppurative epididymitis in one case
after operation; non-suppurative epi-
didymitis in one case after operation.
(A) Operation takes frorii twelve
to thirty minutes. Shock is very
moderate; often absent. Severe post«
operative hemorrhage in two cases,
both recovering. Sexual power — i. e.,
potentia cceundi — retained in all of
the younger and some of the older
patients.
*
HOWABD CBUTOHBB. M. D..
OF CHICAQO, ILL.
(1) The sedentary are, so far as I
am able to see, more disposed to this-
condition than the active.
(2) Fleshy men almost invariably.
(3) I know of no satisfactory ex-
planation.
(4) Of decided value in certain
cases, but not indispensable.
(5) So far as I have been able to-
judge, it occurs as often in the ab-
stainers as in the alcoholics.
(6) I advise palliation in casea
* Another successful case since last communication.
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Prostatic Hypertrophy.
where operdiion does not seem advis-
able. By palliation I mean internal
treatment addressed to the urine, rec-
tal suppositories, and occasionally
local flushings with mild antiseptics.
( 7 ) In no case have I tried the vasa
deferentia for this condition. I doubt
whether this procedure has secured an
abiding place in modern surgery.
(8) In one case, complicated with
tuberculosis of both testicles, for which
latter condition the operation was per-
formed. The result was excellent on
the prostate.
(9) Never performed this opera-
tion.
(10) Many times and with fair re-
sults. Often it is the only procedure
that we can practice with hope of sav-
ing the life of the patient. I have
just operated with success upon a man
of eighty-six years with entire success,
who would have died under a tedious
operation of any sort.
(11) Ten times, with fair results;
no death from operative causes. The
results have been all I had any reason
to expect.
(12) Three times. I like a modified
Kocher incision. While my success
by this route has not been so good as
with the other, I believe it to be the
rational route to the prostate, and
blame my lack of skill with my poorer
results.
(13) The perineal route, for the
reason stated.
(14) My most serious trouble has
been bleeding, which has often been
troublesome and sometimes dangerous,
never fatal.
(A) To give a brief resume of my
prostatic work, I may say that the re-
sults have been all that one has reason
to expect from surgical work in per-
sons of advanced age. Pain being ab-
sent, patients do not present themselves
for treatment until life itself is threat-
ened, when it is frequently too late
for operative treatment to be of any
avail.
HILARY M. CHBISTIi!
OF PHILADBLPHIA,
(1) I have never beei
that occupation had an
producing hypertrophy c
(2) I cannot say.
(3) I am inclined at f
lieve that the overgrow
glandular and muscular
the prostate gland, coi
hypertrophy is first of a
secondarily, inflammator
(4) The cystoscope is
in making a diagnosis,
determining the extent c
into the bladder and the
volved. Nitze or Albarri
(5) I do not think tha
sponsible directly for ph
trophy, but each has a vi
upon the growth after it 1
(6) In nearly all cas
life, irrigation of bladdei
ministration of genito-
septic drugs. Dilatatior
urethra with Kollman.
lator.
(7) Yes; three time
relief only.
(8) Yes; six times; j
two cases ; fair result in
improvement in three csa
(9) Yes; four times;
lief up to present time
complications.
(10) Six cases of bi
bladders with urinary fe\
afford patients considers
of course did not cure.
(11) Twice; one appa
(12) Have not perf on
ation.
(13) TheBottlni in a
with infected bladder
kidneys, because it is saf
subjects supra-pubic p
because it is more thoroi
(14) None.
(A) I am a firm be
palliative treatment of
phied prostate. In casei
cystitis I am in the habit
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112
Original Contributions.
tinuous catheterization. (See ad Thera-
peutic Gazette, February 15, 1901.)
I believe that 80 per cent, or even 90
per cent, of cases can live comfortable
lives with the use of aseptic catheteriz-
ation.
*
OHABLBS CHASSAIGNAO. M. D..
or NEW ORLEANS, LA.
(1) All else equal, sedentary purr
suits seem to predispose, but it may
be because those following them are
apt to be more in the class of those
who apply for relief.
(2) The nervous, I believe. I have
had more patients among the lean.
May it not be in part because it is a
disease of old age, and that the obese
are less likely to live old? In other
words, a coincidence rather than a rela-
tion of cause and effect?
(3) I am an agnostic on this point.
(4) Comparatively small. It assists,
but I rely more on rectal touch, meas-
urement of prostatic urethra, resist-
ance to metallic sound and manner of
entrance of same, etc., as well as pa-
tient's history and symptoms.
I have become accustomed to the
Nitze cystoscope and generally use that.
(5)1 have had patients among total
abstainers as often as among those
who use a good deal of alcohol, per-
haps more.
Constipation, in my opinion, is a re-
sult rather than a cause.
(()) Briefly, in cases that have only
intervals of trouble or ''attacks;" in
oases accustomed to catheter life, who
have learned aseptic precautions, and
are very old ; in those whose general
condition, especially as regards kidney
troubles, would preclude safety in
operation.
(7) No.
(8) Yes. Three. One death;* one
improvement; one unimproved.
(9) Yes. Seventeen recorded cases ;
two recently operated upon and not
yet discharged.
* Death was not immediate, and was preceded by
•cerebral derangement.
One death, apparently from septi-
cemia and uremia. Kidneys were bad,
bladder was infected ; would now pre-
fer supra-pubic drainage or even pros-
tatectomy in such a case, though not
promising for any procedure. One
unimproved except as to easy entrance
of catheter. All others improved. Nine
apparently perfectly well, of whom
five yet under observation ; one of the
cases was in a man, eighty-five years
old, who had had to use catheter with
increasing frequency for many months,
and had not voided urine without it for
several weeks. He remained well for
four years, up to time of his death, at
eighty-nine years of age, from senility
and chronic diarrhea.
In one case had a urinary scrotal
fistula from excessive cauterization
posteriorly; it healed in two weeks
and patient made a good recovery.
(10) Many times. Previously as a
selected treatment, cases not recorded
properly. Within last five years, only
as an emergency operation in cases of
retention with impossibility of cathe-
terization. One last year, with num-
erous false passages caused by awk-
ward attempts at catheterization and
weak from loss of blood. Recovered,
and after closure of fistula was able to
fairly empty bladder; like result in
several .
(11) Twice. One recovery with
good results. One death.
(12) Never yet, but am waiting for
an opportunity. Believe it is perhaps
the best in comparatively young and
strong subjects, as not only they can
stand it better, but, having longer to
live, thoroughness of removal is im-
portant.
(13) Bottini is yet my preference,
chiefly owing to smaller mortality, and
as I have had good results in the ma-
jority of cases.
(14) Can recall only one; in a Bot-
tini case, some extravasation of irri-
gating fluid, boracic solution, subse-
quent to operation, due no doubt to
excessive length of posterior section ;
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Prostatic Hypertrophy.
lis
scrotum was slightly incised for drain-
age and no harm resulted, as catheter
was kept en demeure during healing.
( A ) Data not just at hand to arrai^ge
systematically.
* «>
*
OHA&LBS H. KAYO. M. D..
OP B0CHE8TSB, MINN.
(1) We have noticed but little dif-
ference.
(2) The nervous and lean.
(3) No answer.
(4) It has been useful in differen-
tial diagnosis of prostatic bar and me-
dian lobe hypertrophy ; also in finding
a small stone, once, and an ulcer of
the base of the bladder the real cause
of the discomfort.
(5) While probably not responsible
for the hypertrophy, they act later as
a cause of acute obstruction.
(6) In patients with other physical
infirmities which are more severe than
the prostatic trouble. In extreme de-
bility. In severe cystitis with debility.
Rest, tonics, bladder irrigation or tem-
porary supra-pubic drainage to cleanse
the bladder and induce tolerance for
interference.
(7) Once. Partial relief.
(8) Six times, some with pai'tial,
others complete, relief. Most of these
cases relapsed within two years.
(9) No.
(10) Forty-three times. Improved
condition in all. Many relapsed, some
remained improved, not well.
(11) Thirteen supra-pubic prosta-
tectomies. Good result in twelve. Two
combined supra-pubic and perineal,
with success in one.
(12) Ten perineal prostatectomies.
Good success in nine. Inverted incis-
ion gives most room. Straight me-
dian is usually sufficient.
ri3) At present supra-pubic for
peaunculated middle lobe. Perineal
for most cases.
(14) Found enlarged prostate to be
sarcoma, very bloody. General and
kidney failure.
(A) iVb answer.
HEKB7 H. MOBTON. M. D..
OF BBOOKLYN. N. Y.
(1) iVb an8wei\
(2) iVb anstvet'.
(3) No answer,
(4) The cystosi^ope I find very val-
uable in outlining the size and shape
of the intravesical growths. In several
cases it was only possible to make a
diagnosis of prostatic hypertrophy by
its use, as rectal examination showed
no enlargement at all. In each case,
however, there was an enlarged middle
lobe which acted as an obstruction and
was plainly visible by the cystoscope.
It is always desirable to exclude the
presence of calculus, and this can be
best accomplished by the cystoscope.
The instrument which I use entirely
for this purpose is the Nitze observa-
tion cystoscope.
(5) No answer.
(6) The present high rate of mor-
tality in prostatic operations induces
mQ to advise patients to use palliative
measures so long as they can be made
reasonably comfortable in that way.
Palliative measures consist of regu-
lar catheterization and bladder wash-
ing, and if there is much spasm of the
cut-off muscle and irritability of the
post urethra, the passage of large
sized sounds has seemed at times to be
of use.
^7) No ansiver.
(8) No answer.
(9)1 can give only my general im-
pressions of the Bottini operation,
which I have done in perhaps a dozen
cases.
Its applicability seems to be limited
to the small, hard, fibrous prostates,
which form a distinct bar across the
vesical outlet. Bottini' s operation
seems to me distinctly contra-indicated
in the large adenomatous growths.
With regard to the permanency of
the relief I cannot state, as my cases
all drifted out of sight (they were,
with one exception, all hospital cases),
with two exceptions.
One of these, I understand, relapsed
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114
Original Contributions.
after the operation, and the other
would have temporary attacks of re-
tention from a swelling and closing up
of the incisions made by the Bottini
knife.
The incisions were clearly visible,
however, with the cystoscope a year
after the operation.
His prostate was subsequently re-
moved by Dr. Alexander in Bellevue
Hospital, and six months afterwards he
reported to me that he had been free
from trouble since the prostatectomy.
(10) iVb answer.
(11) iVb answer. *
(12) I have done prostatectomy five
times.
In three cases I made a supra-pubic
incision for the purpose of depressing
the prostate, and enucleated the pros-
tate through a perineal incision.
In the other two cases I simply made
the perineal incision and enucleated
through that.
The incision which I made in the
perineum was the ordinary one for ex-
ternal urethrotomy, and I found that
form of incision gave ample room for
enucleating with the finger. The re-
sults were as follows :
One death from shock forty-eight
hours after the operation.
One death from infection of the
supra-pubic wound one week after op-
eration.
Three recoveries.
(13) I have no operation of choice.
The operations which I consider at
present are: Prostatectomy perineal,
supra-pubic, or a combination of both,
and Bottini' s operation.
The choice of operation, I believe,
depends entirely upon the
a. Form of the enlargement, /. e.,
whether of the adenomatous or fibroid
type.
6. The direction of growth, i. e.,
whether it is chiefly intra-vesical or
towards the rectum, and,
c. The age and general condition of
the patient.
I think that for men who are in fair
health, even though they may be old,
with large adenomatous prostates, per-
ineal prostatectomy, without a supra-
pubic incision, is a suitable operation.
If the prostatic growth is chiefly
intravesical, the supra-pubic operation
may be required.
If the growth is of the mixed type,
I. 6., adenomatous and fibroid, and if
the fibroid elements largely predom-
inate, it may be necessary to make a
supra-pubic opening in order to hold
the prostate steadily while it is being
enucleated from below.
If a large vesical calculus is pres-
ent, a supra-pubic incision may be de-
manded for its removal.
A supra-pubic incision does not seem
to be required merely because the
growth is of large size and extends
high up towards the bladder, since it
is not difficult to enucleate these pros-
tates from below.
With the above exceptions, my
strong preference, based, to be sure,
upon a limited number of cases, is for
the perineal route Without supra-pubic
incision and making only a longitud-
inal incision into the urethra, as in ex-
ternal urethrotomy.
(14) iVb aiiswer.
B(A) iVb answer.
*
STUABT MoGUIBB. M. D..
OF BICHMOND, VA.
(1) I have observed no difference
with regard to occupation of patients
with prostatic hypertrophy. Cases
come to me as frequently from the farm
as from the counting house.
(2) I have observed no difference
with regard to recurrence of the dis-
ease in the phlegmatic or the nervous,
the lean or the obese.
(3) I have no theory or explanation
of the etiology of the disease. Lyds-
ton's theory of sexual overstrain is
controverted by the fact that the dis-
ease is rarely if ever seen in the negro.
Guyon's explanation of the changed
relation of the base of the bladder to
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Prostatic Hypertrophy.
116
the vesical neck is more logical. Ail
that can be said at this time is that
prostatic enlargement is an attendant
of old age.
(4) The cystoscope has been of lit-
tle service to me in diagnosis. I rely
almost entirely upon information de-
rived from the finger inserted in the
rectum and a sound inserted in the
bladder.
(5)1 have never seen the use of al-
cohol or a constipated habit act as a
causative factor in prostatic enlarge-
ment, although they aggravate the
condition when it exists.
(6) I advise palliation in all cases
until symptoms are unbearable, treat-
ment consisting in regulation of the
habits of life, the use of the catheter,
irrigation of the bladder and the ad-
ministration of urinary antiseptics.
(7) No.
(8) No.
(9) No.
(10) Yes, in over ninety cases. Re-
sults are indefinite prolongation of life,
cure of cystitis, relief of pain, but dis-
comfort from unavoidable leakage
from the supra-pubic artificial urethra.
(11) No.
(12) No.
(13) I have not yet decided which
of the •several operations proposed is
best. I believe that prostatic surgery
is in a stage of evolution and propose
to wait and let other men make exper-
iments and then profit by their results.
(14) None.
(A) iVb answer.
W. FBANK GLENK. M. D..
OF NASHVILLE. TENN.
(1)1 have never observed closely,
but upon reflection I find all of my pa-
tients have led active lives.
(2) I have noticed no difference as
to temperament or flesh.
(3) It is unknown to me, but I be-
lieve masturbation in youth, and ex-
cessive sexual indulgence in later years,
to be the chief cause.
(4) I do not get much aid from
cystoscope. I like the Bransford Lewis
instrument.
(5) I believe habitual use of alcohol
and constipation have an influence, but
sexual excess to be the chief cause.
(6) The cases that are well, except
for inability to completely empty the
bladder, I usually advise regular use of
catheter and washing out bladder.
(7) Never did it.
(8) Once, in a man eighty-two years
old. He died.
(9) Never made it. Always per-
form prostatectomy.
(10) Never used it. Prefer perineal.
(11) Never.
(12) Seven times; two deaths, one
from a heart complication ten days
after operation, the other septic peri-
tonitis four days afterwards; oth-
ers recovered.
(13) Perineal prostatectomy. Drain-
age better,
(14) None. Septic peritonize peri-
tonitis once. Stenosis mitral valve.
(A) In the large majority of cases
the result has been all that could be
desired, the patients afterward com-
pletely emptying bladder normally.
N. PENDLETON DAKDBIDGE. M. D..
OF CINCINNATI, OHIO.
(1) The etiology of hypertrophy is,
I consider, entirely unknown. I can-
not trace any connection to any habits
of life.
(2) The condition of body or ele-
ments of character have no influence.
(3) Quien sabe — who knows.
(4) Personally it has been of no
use. The harm it has done probably
fully balances the occasional good.
(5) Have not been able to trace any
connection.
(6) The rule should be proper hy-
giene with the use of the catheter when
it becomes needed under the strictest
aseptic conditions.
(7) No.
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(8) Have castrated two cases with
no benefit.
(9) No.
(10) Supra-pubic drainage is infe-
rior to perineal drainage.
(11) Never.
(12) Once complete with complete
success ; incision, inverted Y.
(13) Perineal — for drainage and
prostatectomy.
(14) N'o answer.
(A) N^o answer.
*
JOSEPH BILUS EASTMAN. M. D..
OF INDIANAPOLIS, IND.
(1) I have observed prostatic hy-
pertrophy with about equal frequency
in men of laborious, active, outdoor
pursuits and those whose occupations
are sedentary. I have, therefore, not
formulated any opinion as to whether
occupation should be regarded as an
etiologic factor.
(2) So far as my limited experience
is concerned, the phlegmatic and obese.
(3) In the course of microscopical
studies of the prostate prosecuted
for the purpose of determining the
origin of * 'corpora amylacea,'' I
have repeatedly noted in glands only
very slightly hypertrophied the clas-
sical tissue changes of inflammation as
described by Green and Cienchan-
owski. I am of the opinion that in-
flammation bears an important causa-
tive relation to prostatic hypertrophy.
(4) The cyetoscope is of slight
value in the diagnosis of this particular
condition. Complications like cal-
culus and cystitis may be more clearly
defined, and with a lens instrument like
the modified Casper, a third lobe may
under favorable conditions be imper-
fectly seen.
(5)1 have not been able to assure
myself that habitual indulgence in al-
coholics predisposes to prostatic hy-
pertrophy. No one of my cases con-
cerned a hard drinker. Whether con-
stipation bears a purely causative rela-
tion I do not know.
(6) Palliation in no case unless op-
eration cannot be borne because of ex-
treme debility. Continuous or inter-
mittent catheterization, bladder irriga-
tion,, neutralization of the urine, stim-
ulation and sedation, emptying of blad-
der in knee-chest position, application
of silver nitrate to prostate per rectum,
sounding, dieting, catharsis, diuresis,
etc., pro re nata.
(7) One case; negative result.
(8)1 have made five castrations for
prostatic hypertrophy with slight tem-
porary relief in two cases. One death
from acute mania.
(^) I have cauterized the prostatic
collar through a perineal incision with
the instruments and after the precepts
of Dr. W. N. Wishard, with satisfac-
tory results. Have secured excellent
bladder drainage by this method.
(10) In one case; I am opposed to
the practice of attempting to coax
water to run up hill, unless for definite
reasons perineal drainage or continuous
catheterization cannot be employed.
(11) One case; pedunculated me-
dian lobe hypertrophy ; good result.
(12) Twice, with favorable results;
the inverted Y incision.
( 13 ) Perineal prostatectomy ; easier
of execution, better control of hem-
orrhage, better drainage.
(14) Acute mania after castration.
(A) My observation and work have
impressed me with the importance of
early operating in prostatic hypertro-
phy. Prostatic hypertrophy is a purely
surgical disease, and all or part of the
prostate, according to the nature of
the enlargement, should be removed
before serious changes in bladder
and kidneys appear as complications.
If we may take the history of other
surgical procedures as our guide, we
may with fairness assume that with
education of the laity and the profes-
sion regarding the importance of early
and thorough operating, the mortality
from this disease may be steadily low-
ered. The operation selected must be
one which will meet the exigencies of
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Prostatic Hypertrophy,
117
the peculiarities of the prostatic de-
formity and stage of the disease in the
individual case.
* ♦
FEBD C. VALENTINE. M. D..
OP NEW YORK CITY.
(1) Most of the patients with pros-
tatic hypertrophy whom I have treated
were and are in sedentary occupations.
I would not, however, conclude here-
from, except in general way, that
sedentary pursuits are essential factors
in this condition.
(2) In my experience the lean old
men and the obese young men.
(3) I have not formed an opinion
on thjs question.
(4) The cystoscope has been and is
of invaluable service to me, especially
in the diagnosis of prostatism, where
the enlargement bladderward is more
marked than rectumward.
I use the Nitze, Casper, Albarran and
Kollmann cystoscopes; often succeed-
ing with one when I fail with another.
(5) a. I do not know, except as
answered to question No. 1.
b. Alcohol and constipation, or either
alone, certainly aggravate the sufferings
from prostatism .
(6) a. When the residual urine is
aseptic and does not exceed 120 c. c.
(f. Siv).
b. Methodical, careful aseptic cathe-
terism, as detailed in ** Surgical Asepsis
of the Urethra and Bladder" (Journal
of the Am. Med. Assn., January 12,
1901).
(7) Yes. Eight. None.
(8^ No.
?9) I have not performed the Bottini
incision for fear of operating in the
dark.
(10) I turn over all capital opera-
tions to operators.
(11) 2^0 answer.
(12) No answer.
(13) No answer.
(14) No answer.
(A) Deeming with Guyon that pros-
tatism is **an infirmity, not a disease"
while the patient can be kept comfort-
8
able and free from danger, ray pros-
tatic work has been and is palliative.
I have no reason to regret this or to
change from the conservative methods.
PAOLA. DE VECOHI. M. D..
OF SAN FRANCISCO, GAL.
(1)1 could not find in my cases any
special reference to the methods of
living;
(2) All my cases were dark in com-
plexion, rather nervous and lean, but I
think this condition was consequence
of the disease.
(3) All my cases were connected
with previous inflammation of the
urethra and bladder due to some in-
fectious diseases and to abuse of coi-
tion.
(4) Cystoscopy has been of a very
little, and unsatisfactory use, in the
diagnosis ; first, on account of the dif-
ficulty of using the instrument on ac-
count of the enlarged prostate^ sec-
ond, on. account of the difficulty of
keeping the water in the bladder clean,
long enough for a good inspection.
(5) The abuse of alcoholics and
constipation were only an aggravating
contribution in two of the cases which
came under my care.
(6) In advanced tuberculosis, in
nephritis, in diseases of the heart
which could not stand anesthetics, in
diseases of the liver with dropsy. Such
cases came under my observation, and
I thought it best not to operate. In
fact, two were operated with fatal re-
sult. In these cat*es palliative treat-
ment must be according to the compli-
cation, and in most cases rest has been
beneficial combined with the treatment
suggested by the special disease.
(7)1 have never practiced it, and I
do not think it rational.
(8) Only once and without success.
(9) The Bottini operation requires a
perfect knowledge of the technic of
the operation, a special skill in han.
dling the instrument which is only f^c.
quired by assisting some skillful oper.
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118
Original Contributions.
ator and by trying it on the cadaver.
I have used the Bottini twice with good
results and permanent relief, and h^ve
used the Bottini modified three times ;
once with good and permanent result,
and twice with only temporary re-
lief.
These same patients were operated
after with other methods without re-
lief.
(10) I have never had an oppor-
tunity.
(11) Only once and with good re-
sults, but found the operation very
bloody and diflScult.
(12) Seven, five with good success;
two are recent and cannot report the
success, although apparently good.
I always made the central linear in-
cision, as described by Dr. Good-
fellow.
(13) The operation described by
Dr. Goodfellow, because it affords a
clear idea of what a surgeon is doing,
and with ordinary skill and patience the
enucleation can be completed even In
the most difiicult cases, and the trauma
is certainly not so severe as in the other
methods.
(14) The only complication during
the operation has been the hemor-
rhage, which was quite formidable in
the supra-pubic. And the complica-
tion which at times gives some trouble
in the perineal operation of Dr. Good-
fellow, is the fistula. However, it
always closed without trouble in my
cases.
(A) (a) Prostatic hypertrophy is a
frequent disease, especially in men
over fifty years of age,
(6) In my cases the causes were al-
ways remote abuse of coition, pro-
tracted urethritis and cystitis.
(c) Ninety per cent, of my cases
could be controlled by palliatives,
gradual dilatation of the urethra, some
times combined with rectal massage.
(d) My choice of operation is the one
described by Dr. Goodfellow, .which
can be called prostatic digital enuclea-
tion through central perineal cut.
WALTBB a. 8PEK0EB. F. B. O. 8.. M. 8.»
M. B.,
OF LONDON, ENGLAND.
(1) mi.
(2) mi.
(3) mi.
(4) Useful as an aid or in confirma-
tion.
(5) N'o answer. •
(6) N^o answer.
(7) iVb answer.
(8) N'o ansioer.
(9) iVb answer.
(10) Many times. Poor, on account
of nervous troubles.
(11) Often. Very good.
(12) Many times with very satisfac-
tory results.
(13) (a) Supra-pubic for large,
soft, mobile, with dilated bladder.
(6) Perineal for hard, fixed with
small bladder, also **collar-like" ob-
struction.
(14) Complications, because case
too late. General and kidney troubles.
(A) I have never done vasectomy
or castration.
Prostatectomy has the advantage of
being a radical method when the pa-
tient is relatively young and strong
enough. If successful the patient may
return to his occupation, and espe-
cially among the poor there are great
difliculties in carrying out treatment
depending upon catheterism or involv-
ing continuous medical attendance, and
many patients, therefore, become pau-
pers.
Supra-pubic prostatectomy is best
done when there is a large bladder
and a pedunculated middle lobe. A
contracted bladder anii a post-pros-
tatic pouch with enlargement of the
lateral lobes are not so favorable con-
ditions. I have operated by the supra-
pubic method when the bladder wa^
contracted with the prostatic obstruc-
tion mainly like a collar, and although
the patient did well, yet the operation
was diflicult, no good view could be
obtained, and, therefore,^ recurrent
hemorrhage might well have taken
place. As regards other ways of per-
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Prostatic Hypertrophy.
119
forming perineal prostatectomy, there
is not such good eicposure of the pros-
tate, and the cauterization by Bottini's
and other methods is done in the dark,
which, if the cautery is too hot, may
lead to hemorrhage and sloughing. If
performed as described there is no
danger of a perineal fistula, although
this would be a trivial matter as com-
pared with a supra-pubic one. Castra-
tion and vasectomy appear to be very
uncertain in their results, and leave a
post-prostatic pouch undrained, with
possibly a calculus in it, so that renal
complications progress.
Conclusion. — The cases quoted in-
dicate that this operation is especially
applicable to certain instances of com-
plicated strictur.e, bladder calculi, and
prostatic obstruction. The unsuccess-
ful cases have shown too advanced
disease of the kidneys. When this
complication had not set in the results
were good.
*
EDKTJND ANDBEWS. M. D.,
OP CHICAGO, ILL.
(1)1 have not observed any effect
of occupation. .
(2)1 have not been able to observe
any difference except that long and
severe suffering seems to promote
leanness.
(3) It is only conjectural. It seems
to me that vigorous men are the most
frequent victims, but I have no scien-
tific proof that sexual excess is an
actual cause.
(4) The cystoscope is of some val-
ue, but not absolutely necessary. I
am not certain which instrument is
best.
(5) The relations of alcoholism as a
cause are not established. Total ab-
stainers are not exempt, and I have
not observed that constipated men are
specially liable.
(6) When the patient can preserve
his health and comfort by the velvet
eye catheter and boric acid injections,
I advise not to operate.
(7) Have ligated the vasa deferen-
tia in a few cases only. Some are
greatly benefited, but not all.
(8) I have castrated a few cases.
Most of them were be — ^^^-^ — ^ ~^
lieved of pain, but som<
had to continue the cal
examined years later sh
prostate had become cc
phied, and yet some of
quired the catheter.
(9)1 have observed t
not practiced it. Some ai
cured or benefited; som
lieved; some few had
continence after it.
(10) Only for tempo
For permanent purposes
operations.
(11) Have not tried i
(12) Have not perse
(13) This question h
settled . At present my ]
cline in the following or
(a) Bottini's operatic
(6)Prof.E.WyllysA
pubic operation, whicl
highly.
(c) Perineal operatio
(d) Supra-pubic opei
cases only. Bottini's o
est (except vasectomy
Andrews' operation tal
the front of the prostate
next to Bottini's in poin
more eflScient. Total p
tectomy is the most dai
three. Total supra-pu
to my is dangerous.
(14) Cannot sufficie
my cases.
(A) iVb answer.
ALBBBT. J. OOH8N]
OP CHICAOO, ILl
(1) I have not been a
cause in the occupation
(2) In my experience
(3) Age, recurrent i
stipation, habitual negh
ing the bladder, habitua
for a long period, seem
corresponding points in
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120
Original Contributions.
(4) I have not used it in these cases.
(5) I could not determine any rela-
tion between the use of alcohol and
hypertrophy of the prostate, but al-
most all of these patients have been
habitually constipated. .
(6) In cases suffering from acute
infections, and in those suffering from
advanced nephritis. Rest, a great
abundance of pure, preferably dis-
tilled, water, and taken at regular in-
tervals, not at meal time. Lavage of
bladder night and morning, with mild
antiseptic. Uriseptin, 5j, in 08s hot
water four times a day.
(7) Yes, eight cases; three cured,
three improved, two not improved.
(8) Yes, seven cases; four cured,
one improved, two died.
(9) No.
(10) I have made this operation
many times in cases in which both
stone of the bladder and hypertrophy
of the prostate were present, but eight
times in cases of hypertrophy alone.
Results: Cured, three; improved,
four; died, one.
(11) Cannot determine number, but
results were so unsatisfactory that I
abandoned the method some years
ago.
(12) Twice the combined supra-
pubic and perineal with one death;
nineteen times the perineal with one
death and eighteen recoveries.
I prefer the Zucker-Kandl incision —
horseshoe— with convexity upwards
from OS pubis to os pubis.
(13) The perineal prostatectomy
through the Zucker-Kandl incision,
because the gland is perfectly exposed
to view, the hemorrhage can be com-
pletely controlled so that almost no
blood is lost. The operation has a
very small mortality.
(14) Laceration of the anterior wall
of rectum one case during operation.
Slight hemorrhage after operation.
Urinary fistula persisting for several
months in two cases.
(A) Surgery of the prostate was
extremely unsatisfactory until the sim-
ple perineal operation was introduced,
I adopted this method fifteen months
ago after seeing it demonstrated by
Dr. J. B. Murphy and Dr. N. H. Fer-
guson, and have used it in nineteen
cases since then with very great satis-
faction and benefit.
JACOB GEIGBB, M. D..
OF ST. JOSEPH, MO.
(1) Occupation and pursuits no in-
fluence.
(2) Nervous and lean.
(3) Gonorrhea and sexual excesses.
(4) Have not used it.
(5) Alcoholic and constipation pre-
dispose.
(6) In the very old and feeble and
those with septic bladder.
( 7 ) Two cases with much benefit.
(8) Three cases; two greatly bene-
fited, one no result.
(9) Have not used.
(10) Four cases; good results.
(11) Three cases; good result ia
two cases, third case no improvement.
(12) Have not performed this op-
eration.
(l^) No answer.
(14) No answer,
(A) No answer.
*
OBANVIIiliE MAO GK>WAK. M. D..
OF LOS ANQSLKS, CAL.
(1) None whatever. The people I
have treated for prostatic hypertrophy
came from all walks of life. They have
been farmers, artisans, merchants,
bankers, stockraisers, mechanics, sol-
diers, miners, tailors, sailors, day la-
borers, preachers, physicians and rail-
road men.
(2) To the best of my recollection,
there have been more individuals who
might be classed as nervous and fewer
classed as obese.
(3) All prostates that I have re-
moved, upon examination present mac-
roscopical and microscopical evidences
of inflammation. But whether inflam-
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Prostatic Hypertrophy.
121
mation has been the cause of the hy-
pertrophy or an accident arising out
of the strains and injuries to the dis-
tended and dilated blood vessels by
foecal accumulations, catheters, or sex-
ual excitement, it is impossible to say.
I confess that I have not been able
to evolve an explanation, satisfactory
to myself, as to why certain men who
are in, or have passed, the sixth decade
of life, develop prostatic hypertrophy
while others escape entirely. If this
were the fate of all old men, it might
be easy to understand it. Or if it fol-
lowed the transgression of certain hy-
gienic laws, one might comprehend it.
But careful inquiry into every case that
has presented itself, numbering now
many hundreds, has failed to give any
definite reason for the occurrence of
the trouble either in the habits or the
occupation of the individuals.
(4) The cystoscope has frequently
been of great service to me in deter-
mining the advisability of doing a supra-
pubic or combined prostatectomy in
place of the less dangerous and more
simple perineal operation, which I
prefer. If there are obstructive tumors
within the bladder, outgrowths from
the prostate projecting into the lateral
or superior quadrants of the bladder
neck, their presence can only be de-
termined by the cystoscope. In such
cases the perineal operation is only a
waste of time. But if there are no
such tumors present, it is foolish and
unnecessary to do a suprapubic or com-
bined operation.
Cystoscopic evidence is also sought
by me to determine the probable value
of theBottini operation in a given case.
If the obstruction is posterior and cen-
tral, a so-called middle lobe growth,
in most instances a prostatotomy by
this method is much less dangerous
and quite as satisfactory in its results,
at least for a long time, as a prostatec-
tomy would be. If the growth is
fibroid or myomatous, or these elements
predominate in the hypertrophy to an
extent that precludes a successful enu-
cleation, the Bottini is the method of
choice. I use a Nitze-Albarran, or
Nitze, or Casper cystoscope for these
examinations.
. (5) I do not believe that the use of
alcohol, or its abuse, is responsible for
prostatic hypertrophy. Many of my
clients have been mildly moderate
drinkers or total abstainers, if any one
can be considered a total abstainer in
America, where the majority of people
who do not drink at their homes, in
saloons or clubs, get their alcohol in
patent medicines without their being
aware that they are drinking. My ex-
perience is that constipation is more to
be considered a result of the hyper-
trophy of the prostate and the conse-
quent rectal obstruction, than it is to
be the cause of it, though, unquestion-
ably, in many instances the presence
of constipation induces attacks of acute
inflammatory edema of the prostate
with retention.
(6) (a) In all cases at the com-
mencement of the trouble and up to
the advent of catheter life. My rea-
sons for this are: 1. That all sur-
gical operations about the neck of the
bladder are serious ones, the outcome
of which cannot be positively predi-
cated. 2. Thereis always a possibility
that the man may lose his life from the
operation. 3. The object may not be
attained, or a fistula may form after it.
4. It is not right to submit a man,
who still has sexual potency, to one of
the mutilating oj>erations simply be-
cause he is certain at some indefinite
time in the future to be no longer able
to pass water.
(6) In the case of individuals who
are well advanced in the disease, but
who are easily catheterized, intelligent
and tractable, the use of the catheter
may be pursued so long as such indi-
viduals are comfortable.
(c) In people who suffer from hem-
ophilia.
(d^ In those who have serious valv-
ular lesions of the heart, accompanied
by great muscular weakness.
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Original Contributions.
. (e) And, most important, in those
who are unable to secrete a reasonable
quantity of urea in each twenty-four
hours — and what I consider a reasona-
ble daily quantity of urea is from 15
to 25 grams.
(/) When the hypertrophy is can-
cerous or complicated by tuberculosis.
In the years of commencing prostat-
ism, the palliative measures I resort to
are those in common use, consisting
principally of massage and the careful
use of the Benique or Guyon sounds or
the Kollman curved dilator, with hy-
gienic measures, and the interdiction
of horseback riding or prolonged sex-
ual excitement. After the advent of
catheter life, prolonged drainage, ac-
cording to the principles taught by
Sir Everard Home and Felix Guyon, I
have very frequently found sufficient,
giving better results than vasectomy,
and quite as good, as a rule, as castra-
tion.
In classes c, d and e, regular cath-
eterization, following the excellent
rules laid down by Edward Martin, is
the best method of procedure.
If the condition becomes intolera-
ble, it is better to resort to the Bot-
tini operation than attempt a prosta-
tectomy. In classy^ a Bottini prosta-
tectomy or suprapubic drainage by the
Senn or Depezzer tubes I have found
very satisfactory.
(7) Yes. I cannot say how many,
but certainly more than twelve, with
no permanent results of any kind at
any time, and with no more temporary
benefit than I have derived many
times from prolonged urethral drain-
age accompanied by instillations or
vesical lavage by solutions of silver
nitrate.
(8^ Yes. Twenty times. In three
instances with apparently perfect suc-
cess. In nine cases with varying de-
grees of benefit. Eight times without
relief of any kind. Upon one of these
cases I did a prostatectomy three years
afterwards. I did not notice any
diminution in the prostate in the in-
terval. I had one of the original cases
operated by Dr. Haynes, under my
care and observation for several years*
For a year following the castration he
seemed to be greatly benefited, then
the prostate increased in size, vesical
catarrh became marked and calculi
formed, requiring lithotrypsis twice
in two years. The obstruction in-
creased to^a point where it was neces-
sary to use the catheter every fifteen
or twenty minutes, and the individual
finally died from his disease. Out of
the twenty there were four deaths di-
rectly attributable to the operation. I
regard castration as more dangerous,
and not to be compared as in beneficial
results with perineal prostatectomy.
(9) Yes. Twenty-nine times. Very
good. Many practical cures. I mean
by that, the ability to empty the blad-
der either entirely or with a resid-
ual not to exceed 30 c.c. Four of
my earlier cases died, but one of these
was due to carelessness upon the part
of an assistant in controlling the cur-
rent, and another directly to my own
ignorance and inexperience at that
period.
One was a paralytic and leaked con-
tinuously, and wore a urinal from the
time of the operation until his deaths
three years afterwards ; but, as he said,
he was much better off in this condi-
tion than he had been with his reten-
tion, when he had been obliged to be
painfully catheterized every half hour.
The others were all greatly benefited
or permanently cured. Three subse-
quently, when their general health had
improved through the palliation of the
Bottini drainage, submitted to pros-
tatectomy. One of these was cancer-
ous and died from secondary hemor-
rhage incident to the prostatectomy.
I did not find the Bottini scars inter-
fered in any marked way with these
enucleations.
One, a man of seventy-four years
who was so weak and ursemic that I did
not dare to do a prostatectomy on him,
had an apparently perfect result for
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Prostatic Hypertrophy.
128
eighteen months subsequent to the
Bottini. Then, the obstruction re-
turning, I did a perineal prostatectomy
upon him without relief, and three
months afterwards was compelled to
cut him suprapubically, and removed
a fibrous outgrowth, which hung down
from the left upper segment of the
prostate into the bladder neck, with
difficulty by the Fuller rongeur. He
is now perfectly well, has control over
his bladder and has restored sexual
power.
The complications I have noticed
have been epididymo orchitis in five
cases, perineal abscess in two cases,
peri vesiculitis in another from a per-
foration of the bladder wall by an an-
terior burn, and once fatal primary
hemorrhage, due to an overheated
cautery in a hemophile.
(10) Eight times. Twice for cancer-
ous hypertrophy, using the Senn drain-
age tube with very good results, the
individuals obtaining perfect relief from
pain and living comfortably for nearly
two years. Three times by the Hunter
McGuire method with some relief and
comfort. But these persons did not
remain long under my observation.
Three times by the Depezzer supra-
pubic retention catheters. These lat-
ter were cases in which catheterization
was impossible or not feasible, and
drainage was required to avoid suffer-
ing, and to prepare, if possible, for
subsequent prostatic operations. They
were all feeble old men, who could not
stand the shock of any radical opera-
tive measures. They all subsequently
died within less than six months after
such drainage was instituted, but were
quite comfortable while they were alive.
(11) Twenty-onetimes. Deaths 5,
cures 14, relief 2.
(12) Twenty-eight times. Deaths 4,
cures 21, relief 3, including two which
may later be classed as cured.
The Chicago incision or inverted j^^.
(13) Median perineal prostatectomy,
the incision is made directly into the
membranous and prostatic urethra, the
capsule of the prostate opened by a
blunt capsule knife from the urethra,
first on one side and then on the
other, the tumors enucleated usually
by the fingers alone. The patient is
placed in the position of eirtreme flex-
ion of the lower limbs upon the pelvis,
the table being slightly in the Trendel-
enberg position. This position was first
suggested and practiced by Dr. George
Goodfellow, of Tucson, and San Fran-
cisco, and adds greatly to the ease of
the operative procedure.
In the greater number of instances
prostatic obstructions can be removed
by this method more speedily, with
less damage to the structures of the
bladder neck, with less hemorrhage
and consequent shock, and with less
space for subsequent infection than by
any other operation. Further, there
is less prolonged confinement to the
bed and the house, and less wetting of
the patient. If all of the obstructions
cannot be removed satisfactorily, espe-
cially in intravesical ones situated in the
floor of the bladder, more room can be
obtained by a section of the floor of the
prostatic urethra and the neck of the
bladder and the bar, if there be one
beyond it, by careful work with a Bliz-
zard in the median line. This will give
all the room one desires, and through
it one can feel almost the entire floor
of the bladder and dig out the isolated,
tumors in the intravesical walls. It
will not retard the recovery of the case,
and does away with the necessity of
the tube drainage.
(14) (a) Irregular rupture or tear
of the bulbous urethra by the careless
handling of the staff on the part of as-
sistants. This was followed in one
case by a fistula, which is not yet en-
tirely closed after seven months.
(b) Excessive primary hemorrhage.
1. Secondary hemorrhage, requiring
in one case suprapubic cystotomy and
followed by sloughing of the rectal
wall from the very tight packing re-
quired of the perineal wound with
gauze soaked in adrenaline chloride
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124
Original Contributions.
solution. 2. Rapid formation of cal-
culous deposits upon the eschars where
the urine was alkaline, requiring intra-
vesical or intraurethral curettage for
their removal.
(c) Sloughing of cellular tissues of
abdominal wall and, once, separation
of pubic symphyses.
(A) In my hospital, dispensary
and private practice during the past
seventeen years I have treated more
than five hundred cases of men for
chronic prostatic hypertrophy, and
had watched most of them go help-
lessly to ground under the old palliative
methods. Faulty as these old meth-
ods are, I am not yet ready to uncon-
ditionally abandon them. I have
given what I regard as a fair trial to
the sexual operations for the relief of
this condition in at least thirty-two
cases, and have followed the experience
of my colleagues in fully as many
more. I see no reason for continuing
to do them. I have used the Freuden-
berg-Bottini or the instrument of
Hugh Young in twenty -^nine cases. It
has its limits of usefulness, but any
general surgeon or urologist who seeks
to give to his prostatic patients the best
care and best advice under all circum-
stances cannot afford to ignore it or
entertain foolish prejudice against it.
His time will be well spent in learning
how to use it. I have employed per-
manent suprapubic drainage eight
times for prostatic obstructions ; when
other measures would be useless or
inadvisable, it is a valuable resource.
As a radical procedure, I have done
twenty-one suprapubic or combined
prostatectomies, and will probably,
unless ray experience rises into hun-
dreds of cases, never do so many
again. I am, however, glad of my
experience, for there are cases that
cannot be dealt with successfully by
any other method. Out of the twen-
ty-eight perineal prostatectomies I
have done, I have met very few that I
would call easy, and but one that did
not give me many uneasy moments.
The general outcome of the prosta-
totomies and the prostatectomies has
been good ; best of all has been that
of perineal prostatectomy. But deaths
occur, and the results are not always
faultless, even in the most skillful
hands.
BOBEBT HOLMES OBEENE. M. D..
OF NEW YORK CITY.
(1) Sedentary pursuits cause con-
gestion and increased discomfort from
an hypertrophied prostate.
(2) The extent, character and nat-
ure of the disease modify the suffering
more than the temperament. Other
things being equal, the nervous.
( 3 ) It is the result of chronic inflam-
mation, causing the formation of con-
nective tissue which plugs up the
mouths of the acini, causing them to
dilate (pseudo adenoma) ; or the in-
crease in the connective tissue takes
place between the acini, causing atro-
phy of the prostate by compressing
them, or if considerable in quantity
causing a fibrous prostate. It gener-
ally commences as a chronic posterior
urethritis from whatever [cause. (See
**Nature of Prostatic Hypertrophy,"
Greene and Brooke.-— Journal Amer-
ican Med. Assso.y April 26, 1902.)
(4) Great service, not necessarily for
diagnosis but for prognosis as well,
showing condition of bladder walls.
Prostatectomy of any kind cannot be
expected to completely cure when
bladder walls much changed in chai'-
acter.
( 5 ) Alcohol and constipation in-
crease urgency of symptoms by caus-
ing congestion.
(6) Stimulate reaction by tonics.
Irrigation of weak solutions of silver
nitrate, etc., when it causes little
trouble. Take on catheter life if nec-
essary.
(7) No.
(8) No.
(9) No.
(10) Danger of infection of supra-
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Prostatic Hypertrophy.
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pubic wound and diflSculty of proper
drainage.
(11) No.
(12) Whenever I have had the op-
portunity, if I could conscientiously
advise it.
(13) Operation as reported by Dr.
J. P. Bryson of St. Louis, Annals of
Surgery, 1902.
(14) Possibility of urethro-rectal
fistula. Of losing a piece of the prostate
in bladder, and of causing impotence.
(A) Given above.
♦ »
*
WILLIAM K. WISHABD. M. D..
OF INDIANAPOLIS, IND.
(1) I have observed no influence
tending to produce hypertrophy from
this cause.
(2) I have noticed no difference.
(3) 1 do not know.
(4) Yes. Occasionally an instru-
ment with a lens system aids in defin-
ing intra-vesical growths, but a direct
view obtained with an air dilation cyst-
oscope in inspecting small growths
about the visical orifice is sometimes
better.
(5) I do not think alcohol has any-
thing to do with it, but constipation
may.
(6) I advise palliative trfeatment
when the symptoms are mild, and when
for any reason an operation is inadvis-
able or declined by the patient.
(7) No.
(i) No.
(9) Yes, I have through an instru-
ment especially devised for the pur-
pose and which I used through a peri-
neal opening (see Journal Uutaneous
and Geni to- Urinary Diseases, June,
1902). Have also used a cautery
through an air-dilated cystoscope. I
use an extra long cautery introduced
directly through the cystoscope. In
one case now under observation the
patient was almost wholly dependent
on the catheter and had some growth
near the vesical orifice on the posterior
wall of the urethra and had been cau-
terized three times at intervals of about
two weeks. The patient is now able to
empty all but one ounce of urine, and
sometimes less has been found with the
catheter, after voluntary efforts at uri-
nation. Five cases where the cautery
has been used through a perineal open-
ing with my instrunient within the
past two years still rei ' ^
well. The cautery wai i
perineal tube in some I
by the writer in the J
neous and Genito- Urinary Diseases in
March, 1892. A small tube was em-
ployed and reflected light from a head
mirror used. The results were appar-
ently permanent and satisfactory, but
no attempt was made to incise large
growths.
(10) Perhaps one-half dozen times,
but I do not regard simple drainage by
this method as of very great value.
(11) Perhaps twenty-five or thirty
times. The results have been more
satisfactory when this method has
been accompanied by a perineal incis-
ion.
(12) Probably sixty-five or seventy
times. I have used a median perineal
incision.
(13) I have no operation of special
choice but try as far as possible to de-
termine what method best suits the
individual case.
(14) I have no especial complica-
tions excepting occasional hemorrhage.
(A) N'o answer,
*
A. E. HALSTEAD. M. D..
OF CHIOAQO, ILL.
(1) My experience tends to show
that indoor pursuits seem to favor
prostatic hypertrophy.
(2) My cases have been nearly
equally divided between fat and thin
individuals. I have no data as to in-
fluence of temperament.
(3) I can formulate no rule regard-
ing the etiology. In a few compara-
tively young men in whom I have seen
hypertrophy, I have reason to believe
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126
Original Contributions.
that chronic prostatitis was of etiologic
moment. I do not believe that vene-
real excess nor venereal disease as a
rule have much influence in producing
this condition. The etiology, I con-
sider, is that of new growths, the
cause of which is yet unknown.
(4) None.
(5)1 believe constipation and rectal
diseases, particularly hemorrhoids,
may have some etiologic significance.
Alcohol ciinnot be considered.
(6) Only when patient is progress-
ing favorably; that is, when catheter-
ization is successful and there is no
great distress nor cystitis resulting
from the catheter life.
(7)1 have divided the vas (vasec-
tomy) in Uoo cases without any appre-
ciable results.
(8) I have performed orchidectomy
in four cases. One recovered; was
well for six months, lost sight of after
that. One died from ether nephritis.
Two were improved — one considerably,
and one slightly.
(9) No answer,
(10) I have operated a number of
times, when I made a supra-pubic fis-
tula. The exact number of cases I do
not know; probably ten (10) at least.
1 believe the operation has a distinct
place in surgery, particularly in cases
where prostatectomy is regarded as
being contraindicated because of the
low condition of the patient.
(11) I have operated by the supra-
pubic route alone but once. I do not
consider it a good operation. In my
case it simply resulted in a supra-pubic
fistula, which relieved the patient for
about one and one-half years, when
he died.
( 12 ) I have done four perineal pros-
tatectomies. In one I did a combined
supra-pubic and perineal because of the
size and position of the tumor. A
curved transverse incision has been
my choice.
(13) The perineal, with a curved
incision above the anus. Where the
prostate is high, and if the tumor was
very large and projected well into the
l^ladder, I would make a supra-pubic
opening to facilitate its removal
through the perineal incision.
(14) The only complrcation that I
have encountered in the operation was
having a large prostate slip into the
bladder, and with difficulty removed
after it had been freed from its at-
tachments.
(A) (a) Vasectomy two cases; na
improvement.
(b) Orchidectomy four cases; one
well for six months ; one death from
operation ; two improved, one consider-
ably, one slightly.
(c) Bottini operations two; evacua-
tion free after operation ; in one im-
provement in cystitis ; in one cystitis
probably increased, no improvement,^
at least; first operated one year, sec-
ond about nine months; in both gen-
eral health improved.
(d) Five prostatectomies, three per-
ineal, one combined, one supra-pubic
Three perineals ^ all living, one six
months, one four months and one
three months after operation; all
greatly improved in general health;
bladder condition in all greatly im-
proved. One combined, two years after
operation, has no supra-pubic fistula,
and can be considered cured. The one
supra-pubic operation lived one and
one-half years, and with supra-pubie
fistula; died of infection of the kid-
neys.
*
BOS WELL PARK, M. D..
OF BUFFALO, N. Y.
(1) No answer.
(2) No answer.
(3) No answer.
(4) Very little.
(5) In my opinion constipation fig-^
ures largely, alcohol but slightly.
(6) So long as patient has no-
troublesome residual urine and no de-
composition attending, nor great diffi-
culty in voiding.
(7) Three cases. Not followed for
final results; temporary improvement...
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Prostatic Hypertrophy.
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(8) Ten or a dozen cases, five with
excellent results^.
(9) Several times. Hospital cases
can't be followed.
(10) Several times, bad results.
Abandoned the method in all save can-
cer cases.
(11) N'o answer.
(12) Eight times, one death. Peri-
neal semilunar flap.
(13) Perineal prostatectomy. Ease
of performance, advantage of perineal
drainage.
(14) N'o answer,
(A) N'o answer.
ANDREW O. SMITH. M. D.,
OF PORTLAND , OBE.
( 1 ) No answer.
(2) No answer.
(3) No answer.
(4) No answer.
(5) I do not believe that alcohol
tends to prostatic hypertrophy.
(6) No answer.
(7) Two. Indifferent results.
(8) Once. Partial relief .
(9) No.
(10) Twice.
(11) Twice. Good results but more
shock and much longer convalescence.
(12) Five times. Best of success,
minimum amount of shock, rapid con-
valescence. Median perineorraphy, as in
urethrotomy, has afforded ^suflBcient
room.
(13) Perineal. Less shock, better
drainage, more rapid convalescence,
simpler, easier, better.
(14) Some sepsis in supra-pubic
cases.
(A) No answer.
OABIi BEOK. M. D..
OF NEW TOEK CITY.
(1) Sedentary tends to it mostly.
(2) The nervous and lean suffer
most.
(3) This is too hard a question for
the busy practitioner. It is probably
a general tendency to sclerosis induced
by rich and sedentary habits.
(4) The cystoscope is of much less
service than thorough palpation. I use
Albarran's lately and Casper's.
(5) The two latter items increase
the tendency considerably.
(6) If the extent be small and the
disturbance accordingly so.
(7) Yes. Twice, and with fairly
good results.
(8) Yes. See Separat-Abdruck aus :
**Monatsberichte ueber die Gesamt-
leistungen auf dem Gebiete der Krank-
heiten derHarn-u. Sexual-Apparate,"
Bd. II, No. 6 u. 7, 1897.
(9) I am opposed to the Bottini,
although I know that in a few instances
relief has been obtained.
(10) Five times. The result was
temporarily good.
ai) Twice. With bad results.
(12) Nine times. Only one fatal case.
(13) Perineal prostatectomy.
(14) Urosepsis after supra-pubic
prostatectomy.
(A) See Separat-Abdruck aus:
**Monatsberichte ueber die Gesarat-
leistungen auf dem Gebiete der Krank-
heiten der Harn-u. Sexual-Apparate,'^
Bd. II, No. (> u. 7, 1897.
♦
BBNEST 0. MABK. M. D..
OF KANSAS CITY, MO.
(1) My cases have been among men
who have, as a rule, led active lives,
though theoretically considered I am
inclined to the belief that a sedentary
life would predispose to hypertrophy
through favoring congestion.
(2) Do not think that these charac-
teristics have any special predisposing
tendencies.
(3) My study in this field has led me
to the belief that prostatic hypertrophy
is the result of a chronic inflammatory
process producing new connective tis-
sue formation. The etiologic agent is
usually the gonococcus.
(4) Cystoscopy has been of great
benefit in determining the character of
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128
Original Contributions.
the hypertrophy, i. e., as to the direc-
tion and extent of the encroachment.
I use Bransford Lewis' instrument
preferably.
(5) Constipation may play a part
in producing congestion.
(6) I advise palliation only in those
cases where a radical procedure is not
to be considered on account of the
physical condition of the patient. Pal-
liation consists of regular aseptic cathe-
terization and irrigations.
(7) Have not done this procedure.
(8) Have not done this procedure.
(9) Have done Bottini's operation
once, in December, 1902, in a patient
seventy-seven years of age. Perfect
success. It is too" early in this case to
make any statement as to permanency.
I am inclined to the belief that the
Bottini does not afford a permanent
cure except in exceptional cases.
(10) Have never practiced supra-pu-
bic drainage for this condition, nor do
I consider it a procedure to be thought
of except as an emergency procedure.
(11) Have never done this proced-
ure, having never found a case suitable
for it.
(12) Have done two perineal pros-
tatectomies with perfect results. The
curvilinear incision between the tuber-
osities of the ischium affords ample
room.
( 13 ) Have no choice and believe that
the operation should be made to apply
to the individual case, the character of
the enlargement being taken into con-
sideration.
(14) Have had no unexpected com-
plications.
(A) Have done two perineal enu-
cleations and one Bottini, all three
cases being successful.
*
0BOBOB O. MAO DONAIiD. M. D..
OF SAN FBANCI8C0. OAL.
( 1 ) My experience leads me to be-
lieve that sedentary occupations favor
prostatic hypertrophy.
(2) Phlegmatic and lean.
N. B.--Probably their leanness is in-
duced by the toxaemia.
(3) Alcohol, gonorrhoeal cystitis
and inflammation of prostate in mid-
dle life, the prostate never having
properly recovered; or, any condition
which causes congestion of the vesico-
prostatic plexus of veins, as excessive
masturbation, toying with females
without proper emission, and liver
conditions which cause the hcemor-
rhoidal veins to become varicosed.
N. B. — All this depends on how the
haemorrhoid plexus is formed; if the
connection via the middle and inferior
haemorrhoidal veins with the internal
iliac is free, or if the blood is carried
back from the plexus mainly by the
superior heemorrhoidal and thus the
portal system; the arrangement
varies in different individuals.
(4) I do not consider the cystoscope
to be of any material service. Any
cystoscope that carries the light at the
distal extremity (bladder) and the
bladder inflated with air.
(5) Alcohol, overfeeding, constipa-
tion and hepatic congestion are factors
in hypertrophy.
(6) This is a hard question to an-
swer. The condition of the patient,
his arteries, heart, lungs, kidnej's, age,
and the size and consistency of the
prostate are all factors which must be
left to the judgment and experience
of the surgeon.
It consists in simply keeping the
bladder clean, regular habits, diet and
catheterization by soft rubber instru-
ment surgically clean. When drawing
off urine have patient on knees and
hands, being most particular that the
end of the catheter is pushed close so
no air enters. bladder.
( 7 ) Have never done this operation,
considering it useless.
(8) Same as answer No, 7.
( 9 ) Have never used this procedure.
Consider it unsurgical.
(10) Do not do this.
(11) Ten times. Four deaths; ex-
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Prostatic Hypertrophy.
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haustion due to shock and hemorrhage.
Six living cases eminently satisfactory.
(12) Once; fatal. Favor the semi-
circular.
(13) Decidedly supra-pubic, be-
cause it is less dangerous, quick, sure,
and all the gland is removed in one or
two pieces.
(14) Supra-pubic: contracted and
hypertrophied bladder, considerable
hemorrhage from the prostatic plexus
of veins, shock, anuria and continuous
hemorrhage of a passive character.
(A) Palliative treatment is generally
unsatisfactory, insomuch as sooner or
later infection appears, with the usual
kidney complications; it is very hard
lo make a patient understand the im-
portance of keeping to the instructions
and living in surgical righteousness.
The kind of instrument, which should
always be soft rubber, and the
difficulty sometimes experienced in
getting even this in when the gland
becomes congested, as it often does
from many and various causes, is ex-
treme. The position on the hands
and knees, so as to draw the paunch
behind the prostate. Uncertainty that
the lubricant used is aseptic, soft and
non-irritating, so that the treatment as
a rule ends up disastrously, and should
not be followed if there be any
chance of a successful surgical intei^-
ference.
The supra-pubic, in my opinion, is
the only one to be followed, that is in
the majority of cases. The chief feat-
ure in the operation is to suture the
bladder to the fascia and skin by an
interrupted catgut stitch, so that the
viscus is well held tip to the abdominal
wall, there is very little trouble in
shelling out the gland, and we are not
working in the dark (notwithstanding
Mayo Robson to the contrary). I
have never had any trouble in getting
the abdominal wound to close within
twenty-one days. Very often in the
perineal method the whole of the
gland is not removed, or only in
pieces, at other times it is loose in its
capsule; in such conditions the peri-
neal makes the better operation so far
as the length of the convalescence is*
concerned, but if the gland is not very
large (and it need not be to cause a
great deal of trouble), hard and very
adherent to its capsule, then there is
danger to slipping into the rectum
with the finger Just in front of the
prostatic urethra, especially if the rec-
tum be thin and atrophic, as it often
is in thin old men. Hemorrhage in
the supra-pubic operation can usually
be controlled by packing, and, in ob-
stinate cases, using gauze wetted with
a saturated solution of alum in the
woundy the balance being sterilized
gauze.
Although I have done a great many
perineal sections for various bladder
and urethral conditions, the only one I
attempted for the removal of the pros-
tate proved fatal, for the reason I
punctured the rectum by my finger.
It was a prostate that would not
readily shell. I had to use my cut-
ting forceps (which I had made on my
own pattern, and found out afterwards
another man had been ahead of me),
while trying to free some of the ad-
herent gland the tip of my forefinger
slipped. Then, of course, I had to
lay the whole business open, sphincter
and all. The patient lived about ten
days, but gradually sank. My four
deaths following the supra-pubic oper-
ation were from exhaustion, caused
by loss of blood due to degenerated
vessels, and because I did not give
them' sufficient individual care. A
surgeon who removes a prostate must
rely on no one until all danger is
passed.
In perineal incisions there is danger
of injuring the rectum while shelling
out the prostate, especially if the rec-
tum be atrophic and the anal sphinc-
ters well marked. If the rectum is rupt-
ured, it is, of course, fatal in old and
debilitated men.
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180
Original Contributions.
J. HBNBT DOWD, M. D..
OF BUFFALO, N. Y.
(1) Excepting those sedentary in-
clined, pursuits (indoor or outdoor)
have but very little bearing upon
hypertrophy of the prostate. In my
experience, men living under either
condition have been equal sufferers.
(2) The large majority of cases oc-
cur in the obese, especially where
there has always been mental activity.
(3) The first seed of prostatic hy-
pertrophy is sown in youth, develop-
ing insidiously as different causes
arise, until a true pathologic condition
is reached:
Youth — Ungratified sexual desire,
masturbation, onanism.
Adult— Abuse of the sexual appe-
tite, follicular prostatitis, gonorrheal
in nature, stricture, unnatural sexual
life and trying to accomplish impossi-
bilities.
(4) Regarding the lateral lobes, the
finger is far superior to any cystoscope
as a diagnostic agent. This instru-
ment may be of value where there is
involvement of the middle lobe.
(5) A sedentary life tends towards
hypertrophy. Alcohol is important
as a predisposing cause. Constipa-
tion must be considered a very impor-
tant factor; it tends to continue, if
not aggravate, the already congested
or inflammatory condition.
(6) Palliation should be practiced
in all cases where no relief, even of a
temporary character, can be obtained
from radical measures. Excepting
in cases where the bladder may be
looked upon almost as a suppurating
cavity, this viscus plays but little part
as a contraindicating agent against rad-
ical measures. On the other hand,
damaged kidneys, even trivial in nat-
ure, but which have existed for a long
time, offer a serious barrier to even a
temporary alleviation of the symp-
toms. Palliative procedures depend
entirely upon the existing condition ;
in some supra-pubic, in others peri-
neal drainage should be the operation
of choice.
(7.) I have tied and taken sections
from thevas several times, but in only
one was there much relief, and this
temporary. It is my opinion that
ligature or section of the vas deferens
for hypertrophy of the prostate gland
is of value, and should be used in cases
where there still remains sexual activ-
ity. Such was the case where tempo-
rary improvement resulted.
(8) In a few cases of castration the
result was practically nil. When any
improvement has resulted, the condi-
tion was similar to that described in
No. 7.
(9) Never performed Bottini's op-
eration.
(10) Supra-pubic drainage should
be considered a procedure of last re-
sort and only palliative. There is no
doubt it gives relief from the urgent
urinary symptoms, but it is always
followed by aggravated bladder com-
plications which make life almost as
miserable as when the urine was com-
ing from below. One patient lived
two years, and for awhile was in fair
shape, but soon the bladder became con-
tracted, stone formed and morphine
as a regular diet had to be resorted
to. In my cases I am not proud of the
results that followed this operation.
(11) I have removed the prostate
supra-pubically but once,, the patient
dying in four days.
(12) Have never removed the gland
from below. From repeated opera-
tions for stone, abscess, etc., I am
convinced that the inverted **Y" in-
cision affords the greatest amount of
room. In using this incision the rec-
tum can be dissected backwards for an
inch or so, thus bringing the gland
clearly into the field,
(13) There is no doubt but that the
prostate attacked in the way described
above can be removed much easier than
by any other method. Using the in-
verted *'Y" incision, with slight turn-
ing backwards of the rectum, transfers
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Prostatic Hypertrophy,
181
the cutting and dissecting process from
darkness to light.
(14) Hemorrhage is occasionally a
distressing complication. Even in the
hands of the most experienced, tearing
or almost complete destruction of the
posterior urethra may complicate mat-
ters. The rectum has been lacerated,
thus handicapping the reparative pro-
cess. Uremia is the most serious
drawback during post-operative con-
duct of these cases.
Second. — Hypostatic congestion of
the different important organs, as the
kidneys or lungs, due to the recumbent
position at an age when the blood ves-
sels have more or less lost their tone.
(A) Prostatectomy is still in its in-
fancy. High mortality can only be
lowered by attacking the gland early
and before the upper urinary struct-
ures have taken on pathological
changes.
»
WILLIAM JONES. M. D..
OF PORTLAND, OREGON.
(1) I have met with it most fre-
quently among farmers.
(2) Have noted no difference in
these different classes.
(3) Any conditions favoring chronic
congestion.
(4) Have not used it.
(5) Not influenced by habit, accord-
ing to my observation.
(6) Cases where there is but little
residual urine and only moderate cys-
titis. Then irrigations, and urinary
antiseptics internally. In very old and
infirm, regular catheterization and irri-
gation in presence of considerable re-
sidual urine and where operation would
not be well borne.
(7) No.
(8) Once. Disappearance of hyper-
trophy, but amount of residual urine
(oz.x) not diminished.
(9) No.
10) Only a few times. Not more
than six. Results unsatisfactory.
( 11 ) Once* After supra-pubic drain-
age for several weeks and in presence
of suppurative orchitis, induced by vio-
lent and unsuccessful efforts at cath-
eterism. Death on second day.
(12) Four times. All lived. All
were made comfortable by the opera-
tion and still are so. Transverse
semi-elliptical.
(13) Perineal. It is done under di-
rect vision. Bleeding vessels can be
secured, shock is less, drainage is more
perfect and the after-treatment is
simpler, neater and shorter. It seems
to me a more accurate and surgical
procedure, less dangerous primarily
and there is less danger from sepsis.
(14) iVo atiswer.
(A) Five cases. One supra-pubic,
septic at time of operation. Old man
died on second day.
Four perineal. One with severe cys-
titis. All recovered and are leading
comfortable lives.
OEOBOE M. PHILLIPS. M. D..
OF ST. LOUIS, MO.
(1) I have not been able to decide
that occupation influences the develop-
ment of strict prostatic hypertrophy.
(2) The greater number of my cases
have been lean and of a nervous tem-
perament.
(3) Undecided.
(4) Rarely have I been able to use
the cystoscope in this situation with
much satisfaction. Usually hemor-
rhage attends the application of the
instrument and renders the parts unfit
for inspection. I think Di^ Brans-
ford Lewis' the best instrument.
(5) The twenty-eight cases that I
have followed and preserved my rec-
ords of, eleven only were addicted to
the use of alcohol in any form.
(6) (a) Extreme age and the debili-
tated.
(6) Hygiene in all that the term im-
plies, rest to the bladder and urinary
tract as far as it is possible to obtain,
all done with a view of developing a
favorable condition for operation.
(7) Yes; in twenty to twenty-five
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182
New Publications,
instances; a small percentage were
really benefited. All for a time ad-
mitted improvement. All in all am of
the opinion that but little real good
was accomplished.
(8) Yes, nine times. I believed at
the time the conditions were improved
in all. Subsequently it developed that
in only three instances were the pa-
tients satisfied. It became necessary to
operate on four, doing a perineal pros-
tatectomy.
(9) Yes, twenty times. I have been
able to follow only eight cases longer
than a month or two ; four of these
were greatly benefited, four improved.
I have had many complications follow-
ing this operation. Excessive and pro-
longed hemorrhage, orchitis and epi-
didymitis in several instances.
(10) Five times. It is a trouble-
some means of palliation, to be resorted
to only when other means fail.
(11) Ten times. The cases that I
have been able to observe as a rule
have fared well. Twice have I had in-
filtration of urine and abscess of the
abdominal wall to contend with ; both
cases recovered.
(12) Sixteen times; the median in-
cision nine times, the curved incision
from tuberosity to tuberosity three
times and the left lateral four times.
The transverse.
(13) Perineal prostatectomy.
(14) (a) Suppression of urine. (6)
Abscesses. Incontinence of urine and
feces.
(A) Not having as correct record of
my work as some, in a general way I
wijl say that all work done here aside
from the removal of the organ is un-
certain. It is my custom to-day to ad-
vise a prostatectomy, either supra-
pubic, perineal, or the two, in all cases
where surgery is positively indicated
and the condition of the patient will
permit.
NEW PUBLICATIONS.
Does the Practice of Medicine Pay? By George R.
Patton, a. M., M. D. Price 10 cento. For sale by
P. Blakiston's Sod & Co., Phlladelphift, Pa.
**Superior to forgetfulness." The
physician who constantly uses Merck's
Manual is never at a loss for the name
of the right drug, the right combina-
tion and at the right time. This little
pocket reference book recalls forgot-
ten therapeutic facts, and thereby
renders the user superior to forgetful-
ness. The Manual is an alphabetical
materia medica and therapeutics, a
complete prescription formulary, a
guide to the latest treatment of poison
cases, and contains much other infor-
matioq of constant interest to the phy-
sician.
International Medical Annual. A Year-Book of
Treatment and Practitioner's Index. E. B. Treat &
Co., New York. 1903. Price, $3.00.
This annual has been a welcome ad-
dition to the physician's library for
twenty-one years, and has increased
in value with each succeeding year. It
places in the hands of the practitioner
a general summary of the year's work,
and enables him in a few of his leisure
hours to estimate the progress of med-
ical science every year. He keeps in-
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new 'methods of treating disease. He
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and sections. General review of ther-
apeutics. Dictionary of remedies.
X-rays, , etc., in medicine and surgery.
Electro-therapeutics. General review
of medicine and surgery. Dictionary
of treatment. Surgical treatment of
cirrhosis of the liver. Diseases of
Egypt. Diagnosis of hip-joint affec-
tions. Sanatorium treatment of
phthisis. Radiography of urinary
stone, and Sanitary science.
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Which yields thirty times ttsvol-
iime of •• nascent oxygen " near
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Full method of treat,
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•• The Thempeutical
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drozone and Glyco-
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Sent free to physicians
on fequest.
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^ J^ka^
Chemist and Graduate of the ** Ecole C^ntrale des
Arts et ManuCscturea de Paris '' (France)
87-59 Prino« Street, New Toi%
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184
Therapeutic Suggestions.
The Amxhioan Yxab-Book of Medicine and Subgebt
TOB 1903. Arranged, with oritieal editorial com-
mentB. by eminent American speeialiatt, under the
editorial charge of Gbobqe M. Oould, A. M.. M. D.
In two ▼olnmes. Philadelphia, New Yorlc, London:
W. B. Saunders & Co. 1»03. Per volume: Cloth,
fS.OO net; Half Morocco, $3.75 net.
We do not know of any similar pub-
lication, either American or foreign,
that can compete in any way with this
excellent Year-Book, published by W.
B. Saunders & Company^ It is not
an indiscriminate collection of extracts
clipped from any and every journal ; the
matter is carefully selected, edited, and
in numerous cases commented upon
by the eminent authorities whom Dr.
Gould has enlisted as his assistants.
Every new theory and scientific discov-
ery worthy of the consideration of the
profession has found a place in this un-
usually complete Year-Book 5 and the
names of the several editors are su&-
cient guarantee of a proper discrimina-
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Saunders' American Year-Bopk as the
best work of its kind on the market.
THERAPEUTIC SUGGESTIONS.
BNLARQBD PROSTATE COMPLICATED
WITH CHRONIC CYSTITIS.
By R. Pabbies, M. D., New York City,
Member of Medical Association of •Greater City of New
York; Physician Mutual Aid Association and Society
for Relief of Widows and Orphans of Medical
Men; Late Visiting Physician .to New
York Magdalene Asylum.
It would be difficult to conceive of a
non-treated enlarged prostate of long
standing withput chronic cystitis as a
conlplicatioii, the latter being an al-
most invariable companion of prostatic
enlargement of the senile type. This
is especially so since it is usually the
symptoms of cystitis which finally call
the attention of the patient to the
changed conditipn of affairs. The
proBtate may have been undergoing
enlargement for a long time, possibly
years^ but the patient continues on his
way in .entire ignorance. Could the
physiciau have been called in during
this period, cystitis would possibly be
unknown as the almost infallible comr
plication. Nor would surgery have an
excuse for playing the prominent part
it does in the treatment of prostatic
enlargement, for, without cystitis, I
question whether the enlargement
would very frequently reach the stage
of a urinary obstruction. The aseptic
catheterization of the patient and
withdrawal of the residual urine before
it has time to becbme ammbniacal
would 80 postpone the day of urinary
interference that the patient would
probably die of old age before this day
would arrive without suffering any
greater inconvenience than an occa-
sional visit to the physician. But,
under no circumstances shpuld the pa-
tient be allowed to catheterize himself,
because, sooner or later, familiarity
will breed contempt, and he will neglect
the. necessary precaution of asepsis,,
with the result of bringing about the
very condition he is attempting to
avoid — cystitis.
The seriousness of this complication
is at once apparent to the physician.
The ammoniacal urine not only in-
flames the walls of the bladder, but the
prostate as well. The enlargement of
the prostate is increased out of propor-
tion to its growth under ordinary con-
ditions. This in turn results in in-
creasing the amount of ammoniacal
residual urine, which, in turn, has
greater powers of damage to the blad-
der wall and prostate. The residual
urine increased, the bladder capacity
is lessened, and the patient voids his
urine more frequently fmd his frequent
straining efforts to empty the diseased
bladder brings a greater flow of blood
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A WISE PRECAUTION
ON THE PART OF THE
\ • /
I
PRESCRIBING PHYSICIAN
When writing a prescription for
Elix. Salicylic Comp.
Would be to carefully specify
i
Warner & Co.
The original and wonderfully effective remedy, indicated in
RHEUMATISM
and analogous disorders.
The fmitations and substitutes are the cause of failures and
injure the reputation of the prescriber and the genuine product-
There is no failure when the ''Warner" product is used.
Literature on request.
>VM. R. WARNER & CO. Philadelphia
nUNCHES: NEW YORK, CHICAQO, NEW ORLEANS, LONDON.
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180
Therapeutic Suggestions.
to the affected parts, resulting in in-
creased congestion, etc. Deplorable
as the condition of the patient now is,
it is generally at this stage that the
doctor first sees his patient. Prognosis,
from a medical standpoint, is naturally
not optimistic, and one at first is led
to accept Sir Henry Thompson's view,
that medicine has practically no place
in the treatment of prostatic hyper-
trophy. Yet, if one were inclined to
be skeptical as to the value of surgery,
the host of operations, from the Fried-
enburg-Bottini and supra-pubic pros-
tatectomy, to castration and ligation
of the cord, would probably suggest
the unsatisfactory field which surgery
has found the enlarged prostate. One
then again turns to medicine with the
hope, at least, of making the patient
**comfortably sick."
A great many remedies are used for
ameliorating the distressing and an-
noying conditions, the most prominent
of which are a dull pain behind the
pubis and frequent urination, especially
during the night, in some cases every
hour or oftener. The two symptoms
alone are sufficient to bring the patient
to a deplorable condition mentally and
physically. The pain can be relieved
by belladonna and opium suppositories,
and the vesical irritability by the in-
ternal administration of sanmetto in
teaspoonful doses before meals and at
bed-time. Tr. of nux vomica in five
to ten minim doses is also of great
value for its general tonic effect.
Locally, when the urine is distinctly
ammoniacal in character, two or three
ounces of an aqueous solution of nitric
acid, one minim to the ounce, should
be injected into the bladder daily, fol-
lowed by sterilized water. At times
several ounces of a solution of nitrate
of silver, one to one thousand ( 1-1000)
once or twice a week will prove of
greater value. Finally a solution of
borax, a teaspoonful to the pint, should
be substituted for the more drastic
nitric acjd and nitrate of silver. The
sanmetto internally, and the washing
out of the bladder with borax solution ,
should be continued after the patient
is well on the way to recovery. While
I am not prepared to state that absorp-
tion of hypertrophied tissue takes
place under this treatment, yet there
is a decided reduction in the size of
the prostate, owing to the fact that
all irritating influences are removed,
and a better condition of nutrition is
established. Hot sitz baths and rectal
enemata are of great assistance in the
treatment, and, I would suppose, mas-
sage of the prostate, although I have
never had to resort to the latter pro-
cedure.
As A SCALP WASH in the treatment of
dandruff, etc., use chaparrin, 1 oz.;
glycerine, i oz. ; good bay rum q. s.,
6 oz. Apply to scalp daily.
One application of chaparrin, when
applied in sufficient strength, will allay
itching for twelve hours.
Acute Catarrhal Cystitis. — In
this condition, with thick, ropy, tena-
cious mucus secreted in immense quan-
tities by the bladder cells, it usually
becomes purulent and the Urine is
loaded with great masses of muco-
pus. Prompt relief follows the use of
uriseptin, given in dessertspoonful
doses four times a day, in hot water.
For the relief of dropsical condi-
tions, especially in renal dropsy from
acute desquamative nephritis, anasar-
cin tablets, one four times a day> will
give astonishing results.
Ecthyma. — The first thing to be
done in these cases is to obtain clean-
liness, proper hygienic surroundings,
and complete abstinence from alcohol-
ics. If there is a general debility,
tonics must be given and the dietary
improved. Locally, all crusts should
be removed with soap and water, the
lesione dressed two or three times a
day with glycobenphene (Heil), and
the parts properly bandag^.
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FIRST OF ALL
insist on rest and freedom
from care; then always prescribe
GRAY'S- -TONIC
COMP.
This, authorities state, will,
if persistently followed, overcome
any case of general debility, nervous
exhaustion or neurasthenia.
THE PURDUE FREDERICK CO.
No. 15 Murray Street, New York
LEUCOKRnE/1, QONOKKHM
If these conditions are accessible to the application of a remedial agent,
n\ J can be resorted to with the fullest degree of confidence,
I ^|*A A Q \ as its component parts have been selected for their es-
JL y 1 V W ^••••^ \ pecial fitness for some form of diseased condition of the
\^ \ mucous membrane of the genital organs, while its col-
A g^^g ^ rk g\^g r\ lective composition effected under conditions of ex-
A |1T1Xr^|1l1^ \ treme high trituration eminently fits it for the entire
^^^***'*^^f^ •'Aw % ggj^ Qf obstetrical and gynecological work,
vv J \ Expressions from clinics of more than one hun-
i r^n^l/rl Al* \ ^^^^ obstetricians and gynecologists, both in Amer-
\ JL 1/ TT U Vl \ ic^ ^^i Europe, indicate its peculiar fitness to these
\^^^^^i^i^^^^ijj^^^^^^^^^J^ sensitive cases. It is wonderful how quickly they
improve in every way on its treatment, whether
of a simple catarrhal, non-infectious, or a gonorrheal, syphilitic infectious nature, It is a
powder very inexpensive, which is readily soluble in water, making a permanent, pleasant,
non-staining lotion.
Enough to make two gallons of standard antiseptic solution will be sent with clinical
reports for 10c. This would make about seven dollars' worth of the usual bottled anti-
septic solution. From THE IOUR»IAL OF THE AHERICAN MEDICAL ASSOCIATION:
"At the Forty-fourth Annual Meeting of the American Medical Association. Llewellyn Eliot. A.M., M.D., Surgeon
to Providence Hospital and Eastern Dispensary, and President of the Medical Association of the District of Colum-
bia, etc.. Washington. D. C. in an article read before the Section of Obstetrics, said:
'In irrigating the cases, we may use the solution of bichloride of mercury, carbolic acid, or any other medica-
tion which individual preference may suggest; for my part, I employ a solution of Tyree's Anti.'ieptlc Powder, which
consists of: parts sod. bor. 50. alumen 50. ac. carbol. 5, glycerin 5. the cryst. prin. of thyme 5, eucalyptus 5. gaultheria
.5 and mentha 5.' "
J. 5. TTREE, CHEniST. WflSniNQTON, D. C.
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Ir88
Therapeutic Suggestions.
fHB RATIONAL TREATMENT OF DROP"
SICAL CONDITIONS.
By a. B. Welbuen, M. D.
In order to elucidate the principles
jind details of treatment in the above
disease, it would be better first to
mention some of its peculiar etiolog-
ical and pathological characteristics.
Dropsy signifies the presence of a
Serous fluid (which has escaped from
the blood vessels) in the subcutaneous
5r submucous celjular tissue, in serous
cavities, or in the cellular tissue of
certain organs. When the subcu-
taneous cellular tissue is extensively
involved it is called anasarca; when
restricted to a limited area it is called
oedema. When this serous fluid ac-
cumulates in the peritoneum it is
ascites. If we have both the sub-
cutaneous cellular tissue and serous
cavities implicated we have what is
called general dropsy. Dropsy results
from a loss of balance between ex-
halation and absorption. It may be
•due to an obstruction in the circula-
tion, to a debilitated state of the ves-
sels and tissues, or an abnormal con-
dition of the blood. A variety of or-
' ganic and functional disturbances will
create all of these conditions.
Success in treatment will be meas-
ured by the ability of the physician to
locate and remove the predisposing
and existing causes. The starting
point of this disease, in the great
majority of cases, is in the heart, liver
or kidneys. Heart dropsy begins in
the feet and ankles, and extends up-
wards. Ascites, in the peritoneum,
from obstruction in the portal circula-
tion. Renal dropsy starts with a
puflSness in the eyelids, face .and
hands. It may finally involve the
whole body as well as serous cavities.
By bearing the above facts in mind,
search for the cause of the disease is
facilitated. After ascertaining the
source of this trouble and addressing
attention to its removal, the next step
is to promote absorption of the fluid.
This is done by the use of diaphoret-
ics, diuretics, purgative^ and general
restoratives. Our aim should be to
deplete overfilled vessels, relieve local
stasis, and promote an uninterrupted
blood current through all the organs
and tissues of the body. How can we
best accomplish this object? Shall we
ply our patient with innumerable drugs
to meet the different indications, or
shall we endeavor to find some agree-
able tnedicinal combination possessing
the specific therapeutic properties to
fulfill these indications, without dis-
comfort or detriment to the patient?
If successful results from the use of
a remedy in disease furnish a guide to
practice, the writer has the strongest
grounds for recommending anasarcin
to the profession, as a most valuable
and reliable remedial agent in dropsy.
The ingredients, as published by the
manufacturer, indicate that it stimu-
lates the heart, equalizes the circula-
tion, is a safe diuretic, ef&cient di-
aphoretic, and promotes the absorp-
tion of accumulated serous fluids. The
writer has carefully tested anasarcin
in a large number of dropsical patients
with the most complete confirmation of
the above claims. A few of the clinical
cases in which anasarcin was chiefly
employed are herewith reported :
Case I. — Anna M., age forty-two;
symptoms as follows: A weak and in-
termittent pulse, palpitations, face
bloated and purple, anxious counte-
nance, dyspnoea, legs oedematous and
painful, urine scanty, foul and charged
with lateritious sediment, serous ac-
cumulations in thorax and peritoneum,
bowels constipated, with some dis-
tention and flatulency. Diagnosis:
Dropsy, from valvular incompetency
and portal obstruction. Treatment:
Mercurial purgation, followed with
two small doses of Epsom salts and
cream of tartar. The patient was then
given anasarcin tablets, one three times
a day, with a small dose of Epsom
salts every second or third day. This
treatment was continued three weeks,
in connection with an upbuilding diet,
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ANASARCIN
(Oxydendron-Sambucus-Scilla Compound.)
A SPECIFIC FOR DROPSIES
Doctor:—
If you know a thing to be a fact, it is not wrong or
unethical to say so. Neither does it smack of quackery or
Charlatanism and should not shock the sensibilities of any,
however refined, cultured or zealous of medical ethics for us
to claim that ANASARCIN is a specific in dropsies, when
clinical experience has demonstrated such to be a fact. If
quinine is a specific in malaria, much more is ANASARCIN
in dropsies resulting from disease of the heart, liver or
kidneys, because that a trial of it in hundreds, yea, thousands
of cases has not resulted in a failure known to us where
directions have been followed.
Besides being a specific for dropsies, it is a permanent
core in the conditions mentioned when begun early and
continued a sufficient length of time, i. e., until the diseased
organs regain normal function. ANASARCIN is composed of
the active principles of Oxydendron Arboreum, Sambucus and
Urginea Scilla» and is sold exclusively to physicians or
druggists for physicians. Trial box free with literature and
testimonials furnished physicians on application.
A DORESS =
The Anasarcin Chemical Company
1 1 WINCHESTER, TENN., U. S. A.
LONDON AQBNTSr^
Thos. Christy A Co., 4'10-12 Old Swan Lane, Upper Thames St, B. C.
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140
Therapeutic Suggestions.
when the patient, being entir,ely re*
lieved, was discharged.
Case II. — ^Mary B,, ag© sixteen;
Symptoms: Pain in right side, feces
clay-colored, urine high-colored,scanty,
depositing lateritious sediment, not
coagulable, tongue coated, bowels con-
stipated, abdomen distended by serous
accumulations, legs cedematous. Diag-
nosis : Ascites and anasarca, from ob-
struction of liver and portal system.
Treatment: Small dose of calomel,
followed by saline purgation, and then
anasarcin tablets, one three times a
day ; small doses of Epsom salts and
cream of tartar were given on alter-
nate days. Under this treatment pa-
tient was relieved and discharged at
the end of eighteen days.
Case III. — Female, age thirty-five,
of intemperate habits; symptoms:
Was confined to her bed with a tense,
swollen and enlarged abdomen, legs
(edematous, pitting on pressure; op-
pressed with suffocation, the urine
scanty, dark-colored and lateritious,
hot coagulable by heat ; violent bilious
vomiting; bowels constipated. Diag-
nosis: Anasarca and ascites, caused by
liver and portal obstruction from in-
temperance and exposure. Prescribed
five grains each of calomel and bicarb,
soda, followed by Epsom salts and
cream of tartar; then gave anasarcin
tablets, one three times a day, a saline
aperient on alternate days, diet nutri-
tious. Treatment continued sixteen
days, with recovery and discharge of
patient.
Case IV. — John W., aged thirty;
symptoms: Pale and anemic, spleen
enlarged, abdomen tense and hard,
with evidence of serous accumula-
tions, extremities oedematous, urine
scanty, high-colored and containing
lateritious sediment; no coagulatioa
on application of heat. Diagnosis:
Ascites and anasarca, from prolonged
attack of malarial fever. Treatment:
Small dose of calomel, followed by
Epsom salts and cream of tartar;
anasarcin tablets, one three times a-
day; tine, of iron, ten drops three
times a day ; Epsom salts and cream of
tartar, small dose every other day;
nutritious diet. Treatment continued
thirty days; recovery and discharge.
Case V. — James M., aged sixteen $
symptoms: Slightly anasarcous in the
extremities, urine scanty and pale,,
slight coagulum by testing with nitrous
acid, shortness of breathing. Diag-
nosis: Anasarca, from mild attack of
scarlatina. Treatment: Hot sponge
bath daily, fifteen drops spts. of nitre
three times a day, small dose of
Kochelle salts every second day, an-
asarcin tablets, one three times daily,
nutritious diet. Treatment continued
twenty-one days, with complete recov-
ery and discharge of patient.
St. Louis, Mo.
INDEX.
Original Conteibutions. paos.
Prostatic Hypertrophy from Every Sargiciil Stand-
Joint by Numerous Authorities—
ohn A. Wyeth, M. D 96
Aufirnstus Charles Bemays, M. D 97
Eugene Fuller, M. D , :... 99
Edward Martin, M. D 100
Branaford Lewis, M. D 100
J. B. Murphy, M. D 103
Orville Horwlt2,.M. D 104
WUliam K Otis, M. D 108
Alexander Hugh Ferguson. M. D 108
Robert Tuttle Morris. M. D 109
B. Mertill Ricketts. M. D 109
Howard Lilienthal. M. D 110
Howard Crutcher, M. D 110
HUary M. Christian. M. D Ill
Charles Chassaignac, M. D 112
Charles H. Mayo, M. D 113
Henry H. Morton, M . D 113
Stuart McGuire, M. D 114
W. Frank Glenn, M. D 115
N. Pendleton Dandridge, M. D 115
Original Contributions. page.
Joseph Rilus Eastman. M. D — 116
Ferd C.Valentine, M.D 117
PaolaDeVecchi, M. D 117
Walter G. Spencer, F. R. C. S.. M. S.. M. B 118
Edmund Andrews, M. D 11^
Albert J. Ochsner.M. D 119
JacobGeiger, M. D ... 120
Granville Mac Gowan. M. D 120
Robert Holmes Greene, M.D 124
William N.Wishard. M.D 125-
A. E. Halstead. M. D 125
Roswell Park, M.D 126
Andrew C. Smith, M. D. 127
Carl Beck. M.D 127
Ernest G.Mark. M.D 12T
George C. MacDonald, M. D 128
J. Henry Dowd, M. D 130
William Jones. M. D 131
George M. Phillips, M.D.... 131
New Publicvtions 132
Therapeutic Suggestions 134
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Is the true nuclein derived from the lymphoid glands of
healthy animals without the use of chemicals, and con-
tains the unaltered vital principles which cannot be made
artificially from plants nor extracted from chemicals.
Indicated in all infectious and toxic conditions, debil-
ity and tissue waste, and locally in the treatment of Ulcers
and Surface Lesions. In fact, in any case where a true
physiological leucocytosis is required.
SAMPLES AND LITERATURE ON REQUEST.
Send for Illustrated Booklet and Fee-Table of our
PATHOLOGICAL, CHEMICAL AND BACTERIOLOGICAL LABORATORIES.
REED St CMRNRICK
42-46 OERMANIA AVE. JERSEY CITY, N. J.
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149
Therapeutic Suggestions,
INDOLENT ULCBRS.
Cases of indolent ulceration that are
so annoying to the general practitioner
may be much benefited by the use of
protonuclein (special).
The form of treatment may be
classed as strictly routine, because a
certain procedure in all cases gives
parallel results. The ulcer surface
should be thoroughly cleansed by the
curette or continuous poulticing. The
use of the curette is more or less pain-
ful and at the same time much tissue
may be destroyed. By poulticing the
necrotic masses will separate and a
general stimulation follow the applica-
tion of moist heat. In old indolent
ulcerous surface it is recommended
that the first four dressings be made
by covering the ulcer with protonu-
clein (special) and then bandaging m
ptace a thick covering of hot wet
absorbent cotton, changing twice
daily. These dressings should finally
be followed by dry dressings of pro-
tonuclein (special). This form of.
treatment will give the best results.
THE TREATMENT OP CARBUNCLE.
The treatment of carbuncle must be
-constitutional and local. At first active
saline purgation is our sheet-anchor,
followed by light stimulation and a
highly nourishing diet. Opiates should
be freely administered when necessary
to reUeve pain and procure rest.
Protonuclein tablets, three at a dose,
frequently repeated, will be of great
service. Sulphate of magnesia, in full
doses with ten drops of dilute sulphuric
acid added to each dissolved dose, will
produce excellent results. Trophonine
later on will prove beneficial. The
local treatment should begin with the
constitutional, and be equally as
thorough. All of the suppurating
outlets should be syringed out with
pure zymocide and a 5 to 10 per cent.
solution of. carbolic acid injected in
various parts of the tumor. Ice bags
should be kept applied from the be-
ginning and continued until the periph-
eral extension is arrested; necrosed
tissue should be removed, but incisions
are of doubtful utility, and are seldom
advisable. Complications may modify
this treatment in some of its details,
but in the main the measures suggested
will arrest the progress of the disease
and prevent septic poisoning.
IMPAIRMENT OP THE DIGESTIVE ORGANS
FOLLOWING THE ADMINISTRATION
OP IODIDES.
During the extensive exhibition of
potassii iodidi, where there is a gen-
eral impairment of the digestive or-
gans, trophonine will be found to be
of the greatest possible benefit— being
a highly palatable and nutritious food,
and at the same time containing the
nuclei-albumen which gives it a most
forcible place during the prolonged
necessary anti-syphilitic treatment.-
Observation has demonstrated that the
lymphoidal structures are greatly stim-
ulated by judicious feeding, so where
we administer a food readily assim-
ilated and at the same time containing
a substance as one of its component
parts which bring about a result pre-
cisely to be desired, such a food im-
mediately becomes a therapeutic agent
and powerful adjunct to other lines
of treatment.
LOCAL TREATMENT OP ACNE.
The skin is first subjected to the
disinfected needle and comedo ex-
tractor until all pustules and sub-epi-
dermic foci are evacuated and the
conspicuous comedones removed. The
surface is then rendered aseptic with
zymocide (pure), which should be ap-
plied several times a day.
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A BI-MONTHLY MAQAZINC DCVOTCD TO THC CONSIDKRATION OF CUTANEOUS
VKNKflKAL OI8KA8K8 AND QKNITO-UfllNARY SUROKRY.
HKDICINC
EDITORS
S. C. MARTIN. M. D. G. M. PHILLIPS. M. D.
^norctsoR op oiiimatolo«v in tm« barncs mcomal oollkoc Miopcnoii or •cnito-urinanv oikams rr, louis ooluoc op=
■T. LOUIS. PMVSIOIANS AND SURaCONS.
MANAGING EDITOR
S. C. MARTIN. Jr., M. 0.
SUBSCRIPTIONS AND ADVERTISING.
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Advertising rates will he furnished upon application.
Address all communications, correspondence, books, matter regarding advertising, and make all checks, drafts
and post-office orders payable to
AMERICAN JOURNAL OF DERMATOLOGY,
Fidelity Building. St Louis, Mo., U. S. A.
Vol.. VII.
JULY, 1903.
No. 4.
MEDIAN PERINEAL URETHROTOMY AND
CYSTOTOMY THROUGH A SUPER-
PICIAL TRANSVERSE INCISION,
APTBR CELSUS.
By Waltbb G. Spencer, P. R. C. 8., M. 8., M. B.,
Surgeon to the Westminster Hospital, London, England.
In some special cases I have found
it advantageous to reach the neck of
the bladder by first making a superficial
semilunar incision across the perineum,
and then a second deep one exactly
along the middle line, so as to lay open
the hinder part of the urethra and the
neck of the bladder.
* Celsus, baying described the holding of the
patient in the lithotomy position by assistants,
and the bringing down of the stone to the neck
of the bladder by the index and middle finger
of the left hand in the rectum, whilst the fin-
gers of the right hand made pressure on the
ypogastrium, says: "Over the neck of the
bladder near tiie anus a lunate incision, the
horns of which point a little towards the hips,
is cut throogh-the skin as far as the cervix of
the bladder; then, below the skin, a second
incimflris to be made, crossing the first where
I do not regard the method as sup-
planting the well-known suprapubic
and perineal operations, except lateral
lithotomy, which has rightly lapsed
into disuse, but as applicable to certain
special cases, such as are detailed be-
low.
There is nothing novel in the pro-
cedure ; on the contrary, it is the ear-
liest of all systematically described
lithotomy operation8,viz. , that given by
Celsus,* book vii, chap. xxvi. It has
been used for perineal prostatectomy,
and is described and figured by Kocher
it is convex, which lays open the cervix until
the urethra is exposed; and so that the wound
is a little larger than the calculus.'' The cal-
culus then comes into view, and may be pushed
out or extracted bjr the fingers or by a special
scoop, against which, if too large, the stone
may be broken by a chisel. Celsus continues:
**Por those who, for fear of a fistula, which in
this position the Greeks call koruada, make
too small an opening, are afterwards brought
tothis very result with still greater danger;
for the calculus makes a way for itself, when
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142
Original Articles,
*(*«Text-book of Operative Surgery/'
by Dr. Theodor Kocher, translated
from the second German edition by
Mr. H. J. gtiles, pp. 163 — IbS, figs.
74 and 75), where it is said to have
been practiced by Dittel and Zucker-
kandl. I am fully aware that this
operation described by Celsus has not
been largely followed, and that by
suggested emendations of the text and
strained commentaries it has been
sought to explain the passage as an
-obscure description of left lateral
lithotomy. I am only concerned to
show that, taking the description of
•Celsus as it stands, his operation agrees
essentially with that which I have car-
ried out. The anus was held out of the
way by the fingers of the left hand,
which drew the stone towards the
perineum; a free superficial incision
was made, and then by a deep median
incision the neck of the bladder was
^divided, not ruptured, sufficiently to
allow of the removal of the stone
without the production of complications
^lUd of a urinary fistula.
The operation, as I have performed
it, is as follows: — ^The patient, pre-
pared by shaving and cleaning, is placed
in the lithotomy position with the
pelvis raised by a sandbag. The cen-
tral point of the perineum is then made
the middle of a horseshoe-shaped in-
cision of the skin, the ends of which
terminate on either side of the anus
Just internal to the ischial tuberosities.
By deepening the lateral portions of
this incision the ischio-rectal fossae are
exposed, and in the middle the ex-
ternal sphincter ani is detached from
its connection with the central point of
forced out, unless it find one. It is even more
dangerous still when the shape of the stone or
its rough surface contributes to this effect,
from which both haemorrhage and over-stretch-
ing of nerves may be produced, which if any
one escapes, yet he will have a larger fistula
by the cervix being torn than he will if it be
"Cum jam eo venit, incidi super vesicae cer-
vicem juxta anum cutis plaga Innata usque ad
cervicem vesicae debet, comibus ad coxas spec-
tantibus paulum: deinde ea parte, qua resima
-plaga est, etiamnnm subcute altera transversa
the perineum, care being taken not to
cut into the bulb or the urethra at this
stage. The anus and the lower, portion
of the rectum are now pushed back-
wards with the fingers and held there
by a flat retractor, the knife not being
used lest the gut be injured. By re-
tracting the anus and drawing the bulb
forwards there is exposed the prostate,
the prostatic and membranous urethra
surrounded by the constrictor urethr®
muscle, the bulb covered by the bulbo-
cavernosus muscle, and the transverse
perineal muscles inserted into the cen-
tral point. Whilst thus retracting the
wound the transverse perineal and the
bulbar arteries or their branches, if
cut, are clamped or tied. The urethra
is next opened by an exactly median
incision, commencing along the median
raphe of the bulbo-cavernosus muscle,
and extending backwards through the
membranous urethra to the prostate.
It is of the greatest importance^ in
order to insure rapid healing, to keep
exactly in the middle line, and there is
no difficulty in doing this without the
aid of a staff, although a median staff »
accurately held, is of assistance where
the urethra is permeable. But there is
no difficulty in making this median in-
cision without any guide when the
urethra and prostate have been first of
all exposed, as described. The urethral
incision must be of sufficient length
from the prostate forwards to allow of
subsequent manipulation without any
tearing.
Having opened the urethra along the
middle line a probe-pointed gorget can
be passed into the bladder, followed by
the finger, which can now fully examine
plaga facienda est, c^ua cervix aperiatur, donee
urinae iter pateat sic, ut plaga paulo major,
qnam calculus sit. — Nam, qui metu fistulse
(quam illo loco Ropvada Graeci vocant) parum
patefaciunt, cum majore periculo eodem revol-
vuntur: quia calculus iter, cum vi promitur
facit, nisi accipit: idque etiam perniciosus est,
si figura quoque calculi, vel aspritudo aliquid
eo sontulit. Ex quo et sanguinis profusio, et
distentio nervorum fieri potest: quae si qnis
evasit, multo tamen patentiomm fistulam
habiturns est mpta cervice, quam habuisset,
incisa.*'
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Median perineal Urethrotomy— Spencer,
143
the bladder, aided by the counter-
pressure of the left hand on the hypo-
gastrium. Owing to the larger super-
ficial wound and the free opening of
the urethra, there is not required that
thrusting to get the tip of the finger
beyond the neck of the bladder char-
acterizing the ordinary median cyst-
otomy, whilst lateral lithotomy opens
the bladder partly by cutting, partly
by tearing the left of the neck. A small
speculum can be passed into the blad-
der and the wall viewed directly by the
aid of a small electric lamp. A rectal
speculum with a slit is of service in ex-
amining an enlarged middle lobe of the
prostate, which will partly project into
the slit. Such an enlargement can be
pinched off or burnt down by the cau-
tery in full view, whilst the speculum
protects the sphincter vesicae from in-
jury. A firm enlargement of the pros-
tate can be drawn downwards into fuller
view by a volsella, and burnt or cut
away whilst the bleeding is completely
controlled. A groove can be burnt in
the middle of the enlarged prostate un-
til the level of the floor of the post-
prostatic pouch is reached, which is
thereby effectually drained, whilst all
injury to the rectum is avoided by the
preliminary retraction. Portions of an
enlarged lateral lobe may be shelled
out or punctured with the cautery point
to promote absorption, and beyond lie
the vesiculse seminales, which are easily
reached by a little further retraction
of the rectum. There is ample room
to U80 lithotomy forceps or a scoop,
and to extract small or medium-sized
stones from bladder pouches, or indeed
to use one of the large perineal litho-
trites. In cases of complicated stricture
with fistulae traveling back towards the
rectum, the urethra is reached by a
median incision behind the stricture,
which can then be traced forwards,
and fistulous tracks outside the urethra
are either excised or slit up.
After the necessary manipulations
are completed the bladder can be
washed out; all bleeding points are in
view and may be tied, or if in the
prostate touched with the cautery.
It is hardly necessary to insert any
plug or tube ; in any case it should be
removed the next day.
When the legs of the patient are
brought down from the lithotomy po-
sition not only do the edges of the
urethra come well into apposition along
the middle line, but the transverse
skin incision does so also in the folds
between the anus, scrotum and but-
tock. This can be clearly demon-
strated by turning the patient on his
side after extending the legs; the
edges of the curved skin incision will
be found to have come naturally into
place. There is therefore no need for
any sutures.
The after history of the cases will
show that the leakage of urine through
the perineum is surprisingly small,
urine being quickly passed through the
penis, whilst the flow through the
perineum ceases in a week or ten days,
owing , to the union of the urethra
along the median line. Following
upon this the skin wound completely
unites, leaving a scar which forms a
slight ridge across the perineum in
front of the anus.
The classical complications, recur-
rent hemorrhage and septic absorp-
tion, are absent owing to the methods
of operating, the free skin incision,
the deliberation of the manipulations,
the exactly median incision avoiding
all rupture and lateral deviations and
pockets, the complete arrest of hemor-
rhage, the free escape of urine after-
wards.
The following cases illustrate the
advantages of this operation.
(a) Urethral Stricture.
Case 1. — ^A tailor, aged forty-nine,
was seen with cystitis and incontinence.
His stricture had followed on several
attacks of gonorrhea, the first twenty
years before. It commenced in the
penile urethra, and was completely
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^^rv«:-j f^m'
1^4
Original Articles.
impermeable even under an anesthetic.
The membranous urethra was opened
behind the stricture, which was di-
vided forwards to one inch in front of
the posterior fold of the scrotum ; an-
terior to this it was simply dilated. A
false passage leading backwards to-
wards the rectum was slit up com-
pletely. The patient was soundly
healed two months after the opera-
tion, the urethra readily admitting a
No. 16 bougie, which he was ordered
to pass regularly at intervals.
Case 2. — A ropemaker, aged thir-
ty-seven, developed a stricture follow-
ing gonorrhea twelve years before.
Dilatation by bougies was attempted,
but this caused great pain, with rigors,
fever and collapse, also epididymitis,
and these symptoms recurred when
dilatation was again attempted. Fol-
lowing the operatian with the complete
division of the stricture exactly along
the middle line, a No. 16 bougie passed
without any pain or other symptoms.
The perineal wound soon healed, and
the patient was dismissed with a No.
16 bougie.
Case 3. — A draper, aged thirty-
eight, suffered from a stricture which
had followed several attacks of
gonorrhea, the last more than ten
years before. Four years previously
internal urethrotomy was done, and he
learnt to pass a No. 9 to 12 metal
bougie. This he could do easily at
first, then with increasing difficulty,
although he tried regularly, until he
could no longer pass the bougie at all.
Increasing frequency of micturition
and straining set in until he had to
pass one ounce or so every hour, night
and day, after much straining. Inter-
nal urethrotomy was again attempted,
and as this failed external urethrotomy
by the Wheelhouse method was per-
formed, and a perineal tube tied into
the bladder to give the front part of
the urethra rest. After draining for
some time nothing could be satisfac-
torily passed. When I first saw the
man, whilst urine was escaping from
the perineum, no bougie could be
passed unless under an anesthetic,
when, after considerable difficulty in
avoiding false passages, I passed a
full-sized bougie. Still no improve-
ment followed, nothing could be
passed except under an anesthetic on
account of the false passages. I
therefore operated as I have de-
scribed, and after dividing the strict-
ure throughout its whole length, ex-
actly along the median line, I found
the tracks of three very indurated
sinuses leading backwards towards the
rectum. Having partly excised and
partly slit them up completely, I tied
a catheter in the bladder through the
penis, and conducted the urine off to
a vessel under the bed. Continuous
drainage and daily irrigation of the
bladder was kept up for five weeks,
when his No. 12 silver catheter could
be easily passed and he was dismissed,
passing this catheter for himself, with
the perineal wound quite healed.
With regard to alternative measures
Cock's operation is valuable when
there is retention with the urethra
dilated behind the stricture or when
there is threatened or actual extravasa-
tion of urine, but it leaves the stricture
in front and any false passages un-
treated. Wheelhouse's operation is
sometimes very difficult, takes a long
time, and unless the stricture is com-
pletely divided is apt to be unsatis-
factory. Moreover, false passages are
left untreated, and hence there is often
a difficulty, especially when the pa-
tient tries to pass his own instrument.
It will be noted that the three patients
were comparatively young, two under
forty and one under fifty, and that the
strictures were complicated. The
method provided a satisfactory cure,
the perineal wound healing soundly,
and the patients being able to pass for
themselves the largest sized bougies..
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Median Perineal Urethrotomy— Spencer.
146
(6) Removal of Calculi.
Case 4. — A cabdriver, aged fifty-
seven, presented the following surgical
history : Six years before he had been
operated upon for stricture; three
jears before a stone had been crushed,
but the removal .was incomplete, and
shortly afterwards supra-pubic lith-
otomy was done. It was a very diffi-
cult operation owing to the very con-
tracted and sacculated bladder. One
year before he underwent lateral lith-
otomy, after which there was severe
recurrent hemorrhage for a week,
which had to be controlled by firmly
plugging the wound. Four months
before being seen by me his stricture
had again been dilated and his bladder
sounded without a stone being found.
I thus had to deal with a patient in
whom a stone had formed for the
fourth time in a very contracted and
sacculated bladder with a partially
strictured urethra. The cicatrix of
the supra-pubic lithotomy wound was
very depressed, and. I learnt that the
operation had been difficult enough at
first; to have attempted a repetition
would inevitably have led to the open-
ing of the peritoneal cavity, and its in-
fection by alkaline urine. Lithotrity
had previously failed, and lateral lith-
otomy had been attended by dangerous
hemorrhage.
The operation therefore was carried
out as has been described ; a large bul-
bar artery was tied on each side, the
neck of the bladder reached, and a
stone the size of a pullet's egg easily
removed from a pouch on the left side
of the trigone. Some phosphatic con-
cretions were also scooped and washed
out. At the same time the opportunity
of fully dividing the imperfectly
cured stricture was taken. No tube
was inserted. There was no further
bleeding, he began to pass urine
through the penis on the third day, by
the end of the week hardly any urine
escaped by the perineum, and in three
weeks the wound had completely
healed. After the previous lateral
lithotomy there had been firm plug-
ging of the wound for a week, no
urine passed through the penis for
three weeks, and the perineal wound
leaked for a long time.
The man continued to wash out his
bladder for two years, and so remained
free from any re-formation of stone.
Then he began to neglect the washing
out, and gradually symptoms of stone
came on agam, with pain in the pros-
tate and orchitis, which went on to
suppuration. I therefore repeated the
operation about two and a half years
later; there was not only a stone in
the same pouch, as before, but also a
number of small calculi in the sub-
stance of the prostate, all of which
were easily retooved from the fully
exposed organ. He likewise recovered
rapidly from this repetition of the
operation. Most of the urine passed
through the penis within the first week,
and the external wound healed in about
a month ; the testis also healed. When
last seen the patient was in good
health, and may continue so if he at-
tends to the daily irrigation of the
bladder.
Oase 5. — A greengrocer, aged forty,
gave the history that about a year ago
burning pain had commenced in the
urethra before and after micturition.
Gradually the pain increased with fre-
quent micturition and occasionally
hsematuria, so that he had to give up
work. During the last two months
the frequent micturition had changed
to complete incontinence, with great
and constant pain in the perineum and
tip of the penis. When seen the pa-
tient was very pale, thin, haggard.
From the urethra was escaping thick
pus, as in acute gonorrhoea, but the
pus was mixed with alkaline urine, for
there was complete incontinence.
Faeces were also being passed involun-
tarily, and he had superficial sores on
his back and buttocks. At first sight
I thought the patient had an abscess
of the prostate, but on examining per
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rectam a large stone could be felt oc-
cupying the neck of the bladder and the
prostatic urethra. A sound easily struck
this stone, but could not be passed
beyond it. By passing the finger fur-
ther into the rectum and examining
bimanually, with the other hand on
the hypogastrium, another stone could
be felt above the first, but held firmly
by a contracted bladder. During these
manipulations thick pus spurted out
from the meatus urinarius.
As the patient was in such pain, and
pus seemed to be retained, I operated
at once by the method described. The
first stone reached, oval in shape and
two ounces in weight, was fixed in the
dilated prostatic urethra and the neck
of the bladder, having its long axis
corresponding to that of the urethra.
It was easily extracted. The second
stone, also oval in shape ^nd weighing
two and one-fourth ounces, was lying
transversely, with the bladder most
firmly contracted over it, and articu-
lating with the first where there is a
facet, so as to form a T. This stone
was manipulated bimanually so as to
turn its long axis into the vertical, and
was then extracted by forceps, aided
by a hand on the hypogastrium.
Both stones are exhibited ; one has
been cut and analyzed; it Is mainly
composed of urates, and shows two
nuclei fused together. After the oper-
ation the patient did not present any
special symptoms; the temperature
gradually became subnormal. Diar-
rhoea set in, and he died on the fifth
day after the operation.
Post'Tnortem. — Both kidneys were
found equally distended with non-
odorous pus, the remaining cortex was
riddled with small abscesses, and sev-
eral abscesses existed between the cor-
tex and the capsule. The bladder was
very contracted and thickened, but not
sacculated ; there was a superficial ul-
ceration of the mucous membrane,
with a few submucous hemorrhages.
The prostate was small and thin, but
not excavated by an abscess. The pus.
therefore, which flowed from the
meatus mostly, came, apparently, from
the kidney. The operation wound was
limited to the cut edges of the prostatic
and membranous urethra. There was
no bruising nor sloughitig nor inflam-
matory infiltration of any kind around
the neck of the bladder.
Case 6. — A tailor, aged forty-one,
had served in the Zulu war of 1879,
where he was attacked with acute in-
flammation of the kidneys, and con-
tinued to pass blood for three month»
(? endemic hsematuria). This left a
"weakness in the loins" until eight
moixths previously, when he began to
suffer from nocturnal incontinence and
passed pieces of stone. Shivering
fits used to come on at night,
and a week before he became rapidly
worse wjth great pain and frequency
of micturition, straining and inconti-
nence. The patient looked very ill, his
urine was alkaline and contained pus
but not blood. On examination per
rectum the prostate was found enlarged
and very tender, and a stone was
struck immediately behind it. His.
bladder could not be washed out owing
to the pain, but it seemed very con-
tracted. Two days before operation
the patient had severe rigors, tempera-
ture rising to 104.6** F., a pulse of
108, with abdominal tenderness and
rigidity. He was in such pain that he
used to sit up in bed and hold his penis.
Some fragments of small calculi were
passed. At the operation a norma)
prostate was reached, but behind it was
a pouch containing many small stones,,
some faceted, some fractured, alto-
gether a handful, 244 grains in weight,,
and composed mainly of urate of
ammonia. The bladder was hyper-
trophied and contracted. The patient
lost his pain and the abdominal rigidity
disappeared, but on the second day he
collapsed and died.
Post-mortem both pleural eavitiea
contained fluid; the lungs ^were
cedematous and bronchitic. There was
a single horseshoe kidney which
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showed marked septic changes ; there
were several small faceted calculi in
the single pelvis and passing down the
two dilated ureters, and two or three
had reached the bladder subsequent to
the operation ; at least the bladder was
fully explored with the finger before
terminating the operation. The blad-
der was intensely congested, with some
hemorrhages. The operation wound
was of the strictly limited character
described in the former case; it had
been a very satisfactory means of
reaching the pouch behind the pros-
tate and in affording free drainage.
It is unnecessary to say much on
such a well-worn topic, yet I think
that these three rather exceptional
cases indicate that occasionally the
operation on the lines described by
Celsus is definitely of advantage. The
two latter cases came under treatment
too late, yet the opportunity of making
a post-mortem examination showed
that the operative interference was
strictly limited to the middle line of
the prostatic and membranous urethra.
At the discussion of the removal of
large stones at the Ipswich meeting of
the British Medical Association much
stress was laid upon perineal lithotrity
for large calculi. The wound I have
made would readily admit the large
lithotrites shown at that meeting.
(c) Prostatic Obstruction.
Oase 7. — A healthy-looking man
aged seventy-two, employed as a mes-
senger, had had increasing pain and
frequency of micturition for two years,
until finally he passed one to two
ounces of urine every hour, day and
night. A sound entered a contracted
bladder and so pushed back a middle
lobe of the prostate that it could be
felt per rectum. All instrumentation
caused much pain, and the bladder
would not allow of more than one and
one-half ounce of water being injected.
A fortnight of treatment in bed with
drugs in no way improved the patient,
and micturition occurred every half-
hour to one hour, day and night. The
prostate was easily reached at the op-
eration, and tt soft pedunculated mid-
dle lobe was found, with a collar sur-
rounding the orifice of the contracted
bladder. Pieces were plucked away
by punch forceps and the rest burnt
down with the cautery, guarded by a
rectal speculum with a longitudinal
slit. A phosphatic concretion the size
of a field pea was removed. The
patient passed three ounces of fluid
through the penis on the third day.
As he was quite relieved he slept well
and rapidly recovered. Fourteen days
after the operation the perineal wound
had quite healed. He returned to his
work as a messenger, and when seen
subsequently had no further trouble.
Cases 8 and 9, — I have had two
other successful cases in patients about
sixty, the obstruction being mainly a
collar-like projection with a small
bladder. They returned to work with-
out need of further instrumental or
other treatment.
The fourth case was unsuccessful.
Case 10. — An Italian wire-worker,,
aged 58, had had difficult micturition
for two years, and had lately very
much pain, pa^^sing a few drops of
urine only at a time. He had an earthy,
wasted look,. and was very weak. The
urine was of low specific gravity, and
contained some albumen. No catheter
could be passed except a silver one,
and that with difficulty. On reaching
the prostate two very vascular lateral
lobes were found joined by a high
ridge which projected into the blad-
der, having behind it a deep bladder
pouch. Through the slit of a rectal
speculum the ridge was burnt away
until a deep channel was made between
the lateral lobes, affording a complete
drain for the pouch. The patient at
first improved, and a fortnight after
the operation got up. He passed
water through the penis ; the bladder
was emptied, and the urine lost its
albumen. However, his pulse never
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^ank below 100, nocturnal deliriam
■and then a typhoid condition super-
vened, and he died a month after the
operation. The perineal wound, al-
though healthy, had not completely
healed. Unfortunately a post-mortem
examination was not allowed, but he
apparently died from chronic
nephritis.
Prostatectomy has the advantage of
being a radical method when the pa-
tient is relatively young and strong
enough. If successful the patient
may return to his occupation, and es-
pecially among the poor there are
great difficulties in carrying out treat-
ment depending upon catheterism or
involving continuous medical attend-
ance, and many patients therefore be-
come paupers.
Supra-pubic prostatectomy is best
done when there is a large bladder and
a pedunculated middle lobe. A con-
tracted bladder and a post-prostatic
pouch with enlargement of the lateral
lobes are not so favorable conditions.
1 have operated by the supra-pubic
method when the bladder was con-
tracted with the prostatic obstruction
mainly like a collar, and, although the
patient did well, yet the operation was
difficult, no good view could be ob-
tained, and therefore recurrent hemor-
rhage might well have taken place.
As regards other ways of performing
perineal prostatectomy, there is not
such good exposure of the prostate,
and the cauterization by Bottini's and
other methods is done in the dark,
which, if the cautery is too hot, may
lead to hemon*hage and sloughing.
If performed as described there is no
danger of a perineal fistula, although
this would be a trivial matter as com-
pared with a supra-pubic one. Castra-
tion and vasectomy appear to be very
uncertain in their results, and leave a
post-prostatic pouch undrained, with
possibly a calculus in it, so that renal
complications progress.
Conclusion. — The cases quoted in-
dicate that this operation is especially
applicable to certain instances of com-
plicated stricture, bladder calculi
and prostatic obstruction. The un-
successful cases have shown too ad-
vanced disease of the kidneys. When
this complication had not set in the re-
sults were good.
PBMPHiaUS VBQBTANS.
Bt L. p. Hambubokb, M. D.,
Instnictor in Medicine, Johns Hopking Unirenitj, and
Maubiob Bubsl, M. D.,
Resident Medical Officer, Johns Hopkins Hospital, Balti-
more. Md.
The conception of pemphigus has
undergone a marked change since the
beginning of the century just past. At
that time any condition of the skin
characterized by a bullous eruption was
included in the class of pemphigus.
There was a leprotic pemphigus, a
syphilitic pemphigus, a pemphigus the
result of burns, a neurotic form, a
form following the use of drugs, and
so on. To such an extent did physi-
cians "torture one poor word*' that
Martins (1) could enumerate, in 1829,
ninety-six varieties of the * 'disease."
Gradually, however, the use of the
word was discontinued in referring to
cutaneous conditions where the etiology
of the bullous eruption was known or
seemed probable. Instead of describ-
ing leprotic and syphilitic pemphigus,
it seemed more approprite to speak of
these eruptions as the bullous exan-
thems of leprosy and syphilis. The
neurotic form came to find its place
under the nervous maladies of the skin
and in a similar manner a number of
other varieties was classified. A con-
tribution to this process of exclusion
was added when Hebra defined ery-
thema multiforme, and thus eliminated
a great group of cases from this cha-
otic collection. It is to this master,
too, that we are indebted for the cri-
teria which determine, even at the
present time, the classification of a
bullous eruption under the caption of
''pemphigus." (2)
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Pemphigus Vegetans— Hamburger— Rubel.
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Essentially a chronic disease of the
skin and mucous membranes of un-
known etiology^ pemphigus is charac-
terized by successive eruptions of bullae
with subjective symptoms, either ab-
sent or present, in varying degree, and
offering a prognosis dependent upon
the particular variety of the disease
under consideration.
At present four varieties of the dis-
ease are distinguished. The common
form, pemphigus vulgaris, has been
long recognized. Its firm bullae, its
tendency to recurrence and its doubt-
ful prognosis are well known. The
differentiation of the other three has
been accomplished by the publication
of a series of three papers which will
be briefly mentioned.
In 1844, Cazenave (3) separated the
variety which has since been repeat-
edly recognized and described under
the title of pemphigus foliaceous. The
flaccid blebs soon rupturing, the sur-
rounding epithelium becomes detached.
The epithelial exfoliation continuing,
great areas of skin are denuded until,
it may be, the whole body is flayed.
The mucous membranes, hair and nails
are in the meanwhile involved, and the
patient, exhausted by sleejplessness,
pain, fever and digestive disturbances,
succumbs.
In the years following Cazenave' s
publication, many obscure examples of
bullous eruptions were described. Each
observer did not hesitate to suggest a
name for the affection he reported,
and so there accumulated a confusing
mass of material. In this group cer-
tain differences were apparent. One
set was characterized by a bullous erup-
tion, frequent involvement of the mu-
cous membranes and slight disturb-
ance of the cutaneous sensibility.
These disorders ran a malignant course,
and were in some instances regarded
as anomalous forms of syphilis.
A second group declared itself by
the multiformity of its manifestations,
for, in addition to the characteristic
bullous and vesicular efllorescences.
other elementary lesions were repre-
sented. These cases showed remis-
sions and recurrences, and did not, as
a rule, attack the mucous membranes.
They were benign and accompanied by
pruritus and parsesthesia. Recognizing
these differences, Duhring (4), in
1884, separated this second group and
created the dermatosis which bears his
name.
No cutaneous disease has given rise
to more lively debate than has Duhr-
ing's dermatitis herpetiformis. Its
very right to a separate existence has
been assailed by no less an authority
than Kaposi (5), and its nosologic po-
sition has not yet been thoroughly set-
tled. It may, however be assumed
that it is entitled to be regarded for
the present as a clinical entity. The
question is bound up in a consideration
of the relation of the disease to other
inflammatory conditions of the skin.
Kaposi would have us regard derma-
titis herpetiformis as a refuge in classi-
fying atypical cases of erythema mul-
tiforme and pemphigus. So long as
etiological, pathological and bacterio-
logical criteria are wanting, the differ-
ential diagnosis must depend upon the
clinical picture and the evolution of
the disease. These are sufficient to
differentiate 'dermatitis herpetiformis
from erythema multiforme in a major-
ity of instances. In the one the irreg-
ular distribution of the lesions and the
striking subjective symptoms contrast
strongly with the preference of ery-
thema multiforme to attack the dor-
sum of the hands and feet and with
the usual absence or mildness of itch-
ing and burning.
The relation of Duhring' s dermato-
sis to pemphigus, however, is much
more intimate. Indeed, Duhring him-
self states that '*The semblance in
some, but by no means all, cases to
pemphigus naturally suggests a close
relationship of the two diseases, and
that such exists in these cases there
can be no doubt." (6) He reports a
case in which the condition at one
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time would have been diagnosed pem-
phigus, and which he subsequently
classified as dermatitis herpetiformis
because of the presence of peculiar
vesicles, blebs and pustules in combi-
nation. Though it is unquestionable
that the polymorphism, the herpeti-
form arrangement of the lesions and
the subjective symptoms create a spe-
cial place for Duhring's dermatosis, the
grouped and subjective symptoms are
at times prominent, so that there are
well recognized and generally accepted
examples of chronic pemphigus, which
form connecting links between the
commdn varieties and dermatitis her-
petiformis. The modifying terms ser-
piginous, pruriginous and gyrate illus-
trate this transition. The future may
provide an etiological basis for a more
Pig. 1. — The prominent vegetations in the groin are here depicted.
crusts are seen on the abdomen.
Two of the impetigo-like
intimate relation to pemphigus should,
for the time being, be emphasized by
considering it as a variety of this dis-
ease. The commoner types of pem-
phigus itself do not always present
uniform pictures, and, though the
characteristic lesion is a bulla, the bleb
may rise from an erythematous base,
and wheals and pustules may be pres-
ent. The eruption is occasionally
satisfactory classification, but until
then it seems advisable to group with
pemphigus vulgaris and pemphigus
foliaceous, Duhring's dermatitis her-
petiformis.
The fourth variety of chronic pem-
phigus was defined by Neumann in
1886. It is from this form of the dis-
ease, pemphigus vegetans, that the
patient, whose history and condition
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Pemphigus Vegetans-Hamburger—Rubel.
161
will subsequently be recounted, suf-
fered. The early history of this disease
was referred to in sketching the ori-
gin of dermatitis herpetiformis. There
a certain class of bullous eruptions
pursuing a malignant course was con-
trasted with a ffroup of benign affec-
tions which Dunring embraced in the
description of his dermatosis. It was
also stated that they were sometimes
regarded as varieties of syphilis, and
it may be added that this view contin-
ued to be held until Neumann recog-
nized their connection with chronic
pemphigus, and published his opinion
in the Vierteljahschrift fuer Derma"
tologie und Syphilis in 1886. (7)
Pteviously, under the title of herpes
vegetans, Auspitz (8) described what
Neumann viewed as the affection under
consideration. Moreover, a syphilis
cutanea papillomaformis (vegetans) or
framboesia syphilitica, Kaposi (9) re-
ported a case likewise supposed to be
of a similar nature. In none of these
instances is the condition of the mu-
cous membranes indicated. Besides,
in the patients of Auspitz the occur-
rence of pregnancy and the presence
of syphilis in one of them complicated
the diagnosis. At the present moment
the inclusion of both Auspitz and
Kaposi's cases with pemphigus veg-
etans might be questioned. But there
can be no doubt that Neumann had
seen this form of pemphigus and had
fallen into error. The patient whose
condition he, as well as Hebra, re-
garded as luetic, and whose case was
published as such in 1876, was, he
subsequently determined, a victim of
pemphigus vegetans.
This patient was a lady thirty-one
years old whom Politzer asked Neu-
mann to see in January, 1875. She '
was then complaining of great discom-
fort on swallowing. Her illness dated
from the previous November, when
blebs appeared in the right axilla.
Bursting, they left a raw, moist sur-
face on which granulations appeared.
The mucous membrane of the lower
lip, mouth and fauces became affected
so that the patient could take only
liquid nourishment. The condyloma-
like axiUary vegetations led to a diag-
nosis of syphilis. Subsequently the
vegetations appeared on the abdomen,
in the groins, and over the labia ma-
jora. The various orificial mucosae
became affected.
The disease progressed steadily,
other blebs, isolated and confluent,
developing in the axillary region, on
the chest, abdomen and back. The
exfoliation of the epidermis left raw
surfaces like a burn of the second de-
gree. There was considerable pain
and the eruption exhaled a foul, al-
most unbearable odor. Uninfluenced
by the remedies administered, the pa-
tient died, emaciated and exhausted,
after an illness of four months' dura-
tion. The only comfort afforded the
sufferer was the use of the full con-
tinued bath.
Before the patient died it became
evident that the condition was an in-
dependent affection, uninfluenced by
antisyphilitic treatment, and, in truth,
bore relation to the group of chronic
pemphigus. Then Neumann recalled
two previous instances in which the
erroneous diagnosis of lues had been
made, and, together with six other ex-
amples subsequently recognized and
correctly interpreted, published his
paper on the basis of these nine cases.
Almost simultaneously and inde-
pendently Mr. Jonathan Hutchinson
called attention to "A Form of Chronic
Inflammation of the Lips and Mouth
which Sometimes Ends Fatally, and
is Usually Attended by Disease of the
Skin and Nails." (10) With his char-
acteristic accuracy of observation and
recording he gives an account of sev-
eral cases of ulcerative stomatitis, with
and without cutaneous eruptions, to
which his attention had been directed
during the previous ten years. He
points out that a question might arise
as to whether all of them are of the
same nature, and from our present
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152
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knowledge it seems more probable that
they are not similar. Yet, in the first
group he recites the histories of two
cases of pemphigus vegetans without
assigning, however, a name to the
affection. But in a few words he
shows clearly its distinguishing feat-
ures and makes a surmise as to its re-
lation to pemphigus. *'The cases are
important," he writes, *'on account of
their severity and from their close re-
semblance in some instances to syph-
ilis;'* and again, in portraying the
eruption, he describes '^bullee like
those of pemphigus." He adds:
**When the buUse broke, papillary ex-
crescences sprouted up from .their
base." Though Mr. Hutchinson gives
such a clear representation of the dis-
ease, nevertheless it is Neumann's pa-
per that has led to a general recogni-
tion of pemphigus vegetans. The
French give him due credit by^ calling
the affection "Maladie de Neumann."
The subsequent history of the disease
is contained in the publication and dis-
cussion of about fifty cases, from
which a survey of its features may be
made.
Pemphigus vegetans is not a com-
mon disorder. In this country, J.
Nevins Hyde is the only observer to
report a case. (11) It is a disease of
adult life, and spares neither sex. The
patient is in good health until attacked,
and neither the family history nor the
occurrence of a previous illness throws
light on the etiology. Mr. Hutchin-
son comments on the fact that his
patients were residents of the country.
Statistics drawn from the recorded
cases regarding the occupations and
residences of sufferers from pemphi-
gus vegetans cannot be compiled, for
the published details are too meager,
but it is rather interesting to note that
our patient, as well as Danlos and
Hudelo's, (12) were both farmers.
In the discussion of the latter case,
Brocq mentioned that he had seen the
disease in a peasant, and that there
were "aphthous cows" on the farm.
The interpretation of these facts must,
for the present, be left undecided.
The disease usually commences with
soreness in the throat and mouth. In
the present instance tiny pinhead-
stzed vesicles could be detected on the
dorsum of the tongue, but owing to
local conditions of beat and moisture
the blebs here do not long retain their
form. Therefore, an examination usu-
ally reveals the mucous membranes of
the mouth and fauces more or less
eroded and partially covered with a
yellowish pellicle of macerated epi-
thelium. Hoarseness^ pointing to an
involvement of the laryngeal mucosae,
was the earliest symptom in our pa-
tient. In Ludwig's patient the pre-
putial sac and urethra were first af-
fected. (13) The conjunctiva may
suffer, and it is said that even the
vaginal portion of the uterus and the
rectum have been attacked. The af-
fection of the mouth and throat is
usually misinterpreted, and it is only
when the characteristic bullous erup-
tion makes its appearance that the true
nature of the condition becomes mani-
fest. Occasionally this eruption marks
the inception of the disease, followed
later by involvement of the mucous
membranes.
The interval between the onset of
the stomatitis and the appearance of
the bullae is usually one of days or
weeks, but exceptionally (as in one of
Koebner's oases) two years passed be-
tween the oral affection and the ap-
pearance of condyloma-like growths
in the groins. (14)
The evolution of the eruption could
be readily traced in the present case.
Here the earliest lesion was a vesicle,
the smallest being about 2 mm. in di-
ameter. Enlarging, a bulla somewhat
lax and pendulous, and attaining a
diameter of 1.5 to 2 cm., was formed.
On opening the bleb a clear, transpar-
ent, straw-colored serum exuded. In
from two to three days the bulla be-
gan to exhibit yellowish points at its
most dependent portion. The area of
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Pemphigus Vegetans— Hamburger— Rubel.
168
opacity having increased, the serous
contents of the bleb finally became
purulent. At this .stage there devel-
oped a red areola about the lesion.
Soon the thin layer of epidermis en-
closing the pus ruptured and there was
thus disclosed a red, raw, weeping sur-
face, partially covered by the col-
lapsed epidermal wall. The adjacent
patches now became confluent, and the
epidermis of the surrounding skin was
lifted up so that the process spread in
all directions, forming large areas
many centimeters in diameter, at the
last vestige of the dead epidermis dis-
appeared, and from the denuded sur-
face there sprang a gray papillary out-
growth to a height varying with the
location. On the arms and abdomen,
where there was little mechanical irri-
tation, it was not prominent; but in
the axillse and groins and over the
back, regions exposed to friction, the
papillary vegetating, condyloma-like
character of the lesion was strikingly
illustrated.
The cutaneous lesions may attack
any portion of the body surface, but
Fig. 2.— The illustration shows lesions on the back. Most of them are excoriations, about the
borders of many the remains of the vesicle can be seen. One of the large crusts
can be seen in the infrascapular region on the left side.
periphery of which a ledge of epi-
dermis, 2 to 5 mms. in width, re-
mained adherent. In other places the
true skin was not exposed, but came
to be protected by the formation of a
thick, yellowish brown crust, which,
too, was fringed by the attached edge
of the remains of the original bulla.
Here, as in the previous condition, an
inflammatory halo encircled the lesion,
giving the whole an ecthymatous ap-
pearance. Whether this crust formed
or the tender surface became exposed,
the end process proved the same. The
the perigenital, axillary, umbilical
areas and the regions bordering on the
orificial mucosae are seats of predilec-
tion. Except in the groins, pemphi-
gus vegetans does not tend to show a
symmetrical distribution.
In three of Neumann's cases the
nails were affected, blebs appeared at
their roots, the nails were discolored
and lifted from their base by granula-
tion tissue and pus. In a fourth case,
recently reported, all the nails were
the seat of such changes. (15)
In the present instance a small bulla
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as well as the vegetations was exam-
ined microscopically. The early le-
sions exhibited the signs of inflamma-
tion without any specific characters.
With the exception of the layer of
columnar epithelium, the entire epi-
dermis took part in the formation of
the bleb's wall. The corium was the
seat of around-celled infiltration. The
vegetations consisted of hypertrophied
papillae with their covers of stratified
epithelium and their dilated blood ves-
sels. Leredde and likewise Gastou
have found eosinophiles in great
abundance in the cellular infiltration of
the epidermis. Such was not the con-
dition in the present case.
Our bacteriological studies have
been of interest. Cultures from the
bullae showed only the staphylococcus
pyogenes aureus ; but from the mouth
and, it may be added, from the blood
after death, a bacillus belonging to the
pseudo-diphtheria group was grown in
pure culture. This organism pre-
sented a similarity to the pseudo-diph-
theria bacillus which Waelsch has
twice isolated from recent blebs and
from the blood of two patients suffer-
ing from pemphigus vegetans. (16)
Both our organism and Waelsch 's ex-
hibited irregular staining properties
and polymorphism, and both were
pathogenic for guinea-pigs. There are
these differences, however: our bacil-
lus did not stain by Gram's method,
while Waelsch's did retain its coloring.
We could rediscover the organism in
the blood of the dead guinea-pigs, but
in Waelsch's animals the blood was
sterile. In neither series of observa-
tions were changes resembling those
of pemphigus vegetans found.
Aside from the condition of the mu-
cous membranes and skin, pemphigus
vegetans has no characteristic symp-
toms or signs. Itching is not a prom-
inent feature, but the excoriation
causes much pain and burning.
Irregular attacks of fever may usher
in fresh eruptions or may occur inde-
pendently.
Albuminuria and gastro-intestinal
disturbances are not infrequent.
Leredde (17) lays great stress on
the occurrence of an eosinophilia. In
his own cases, as well as in one of
Neumann's and Danlos and Hudelo's,
the eosinophilic cells were augmented ;
in the latter to six per cent. We
noted particularly that in our own
cases no such increase in eosinophiles
occurred. The absence of eosinophilia
in the present instance is significant in
view of Coe's obervations on its prog-
nostic import in pemphigus, (18) his
suggestion being that the presence of
eosinophilia may betoken a more fa-
vorable outlook.
Symptoms referable to the nervous
system have been occasionally de-
scribed. In three of Neumann's pa-
tients the tendon reflexes were exag-
gerated, and two of them suffer^
from muscular contractures in the ex-
tremities. In the third there was, in
addition, ptosis of the right eyelid. A
muscular tremor has also been noted
by Herxheimer. (19) The patient in
our care exhibited a certain mental
sluggishness. While under observa-
tion he was somewhat stuporous, re-
sponding to questions slowly and only
after the lapse of a noticeable interval
of time.
The course of pemphigus vegetans
is marked by a steadily progressing
cachexia in spite of periods of marked
amelioration in, the condition of the
mucous membranes and skin. Indeed,
the integument may assume an almost
normal appearance and yet the sufferer
may be separated from death by only
a few days. Pneumonia, nephritis
and intractable diarrhoea are the usual
terminal events. The duration of the
disease varies from a few weeks to
fourteen months, usually less than a
year. There are two reported excep-
tions to this statement. In both the pa-
tients lived ten years after the inception
of the infection. The first is the one
seen by Neumann in Hebra's clinic,
and whose condition is- briefly de-
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Pemphigus Vegetans— Hamburger—Rubel.
105
scribed and illustrated in Kaposi's
(20) Atlas. The other was reported
by Koebner. (21)
It is the case of a man thirty-two
years of age, who suffered in 1886
from blebs and ulcers over the mu-
cous membranes of the cheeks and
tongue. In 1888, condyloma-like
gro?rths uninfluenced by mercurial
treatment were present in the gluteal
region. For the next several years
the lesions in the mouth recurred.
In 1890, the bullous eruptions with pap-
illary excrescences appeared in the
groins. Treatment by curetting
brought relief and he was said to
be in good health in 18i^3. Two years
later the malady returned and death
ensued after an illness of a year.
Thus it will be seen that the appar-
ent recovery is only a respite, death
is the ultimate result.
Post-mortem, no changes in the in-
ternal organs have thrown light on the
nature of pemphigus vegetans. In
one of Mr. Hutchinson's cases a lai^e
lympho-sarcomatous tumor was found
in front of the spine, imbedding the
pancreas and large vessels. In our
patient a similar neoplasm was situated
in the anterior mediastinum, presum-
ably having its origin in the thymus.
In none of the other published autop-
sies were such tumors disclosed. The
causal relation is, therefore, not evi-
dent, but it is proper that this coinci-
dence between Mr. Hutchinson's case
and the present one should be indi-
cated.
The nervous structures have been
repeatedly studied in the hope of throw-
ing light on the origin and nature of
the disease. Unfortunately, examina-
tion of the brain and cord of our pa-
tient was not permitted. The first,
second and third dorsal spinal ganglia
were excised, however. They exhib-
ited no gross alterations. Microscop-
ically, the ganglion cells showed inter-
esting changes, the chief of which
consisted in a marked increase of pig-
ment. Some cells were three-fourths
occupied by the pigmented granules
while many showed one-half the cyto-
plasm thus replaced. Others pre-
sented signs of degeneration in that
the outline of the nucleus was wanting
and the nucleolus had l^ecome indis-
tinct. Marianelli ^22) has also ob-
served this hyperpigmentation in the
cells of the upper cervical ganglia of
the sympathetic, and degenerative
changes similar to those just described
but having their seat in the cells of the
anterior comua and Clarke's columns
have been noted in a case of pemphi-
gus vulgaris by Brochieri.(23) These
alterations have probably no bearing
on the causation of pemphigus vege-
tans; indeed, they are, doubtless, as
Koebner points out, secondarily de-
pendent on the toxaemia of the disease.
It follows then that neither bacte-
riological nor pathological studies (24)
have furnished means of identification
and the diagnosis of the disease must
rest on its clinical aspect and course.
Fully developed, the affection has
been most frequently mistaken for
syphilis. *'Though the patient's mor-
als," writes Neumann, Vwere thus in-
dicted, on the other hand, the hope
of recovery was held out to him." (25)
To be saved from such an error the
diagnosis becomes a matter of impor-
tance.
The elementary bullous eruption
should, when present, lead to a recog-
nition of the pemphigoid nature of
both the vegetations and the lesions of
the mouth. If the blebs have been
effaced, subsequent efiiorescences alone
or together with the stomatitis, should
make the diagnosis clear. Aside from
the bullae, the superficial nature of the
excoriations and certain characteris-
tics of the vegetations serve to differ-
entitate pemphigus vegetans from
syphilis. The former grow rapidly
and the remains of the bleb may be
detected at the periphery of the vege-
tations ; the border of a condyloma is
firm and indurated. Neumann also
calls attention to the stippled appear-
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156
Original Articles.
ance of the vegetations as opposed to
the uniform deposit which may cover
a condyloma. Finally, the absence of
a history of lues, the ' fact that other
evidences of syphilis are wanting, and
the injurious effect of antisyphilitic
treatment, which was noted in our pa-
tient as well as in other of the recorded
cases, these data contribute to estab-
lish the correct diagnosis of pemphi-
gus.
Little need be added to what has
already been said regarding the differ-
disorders from Neumann's disease.
Here they do not present the asym-
metry of pemphigus vegetans. Neither
does a single bulla, as in the latter
disorder, by its eccentric extension,
come to involve a considerable area of
skin. Lastly, they point out the fa-
vorable influence of local treatment on
the cutaneous manifestations of pem-
phigus vegetans as contrasted with its
usual failure in dermatitis herpeti-
formis and pemphigus vulgaris.
There are a number of other der-
FiG. 3. — Represents the earliest lesion described, the vesicle. It will be seen that serum
hks accumnlated in the stratum mncosum and has lifted np the greater part of that layer,
leaving the columnar cell layer still attached to the corium. Here and there groups of poly-
gonal cells have also remained adherent to the true skin.
The portion of the epidermis forming the walls of the vesicle is thinnest at the summit of
the bleb, where it is made up of but two layers of flattened cells; from this point toward the
margin the layers become more numerous until the entire normal thickness is reached.
Great numbers of leucocytes, especially the polymorphonuclear, are seen both within the
vesicle and upon its surface. The contents of the bleb consist mostly of serum, leucocytes and
epithelial cells in various stages of degeneration.
In the framework of the corium, especially about the blood vessels, there is marked round-
cell infiltration, but here and there are groups of neutrophiles. In almost every papilla two
or three dilated capillaries are found distended with blood.
entiation of the other members of the
pemphigus group from pemphigus
vegetans itself. It is well known that
they may exhibit, at rare intervals,
vegetating lesions. Indeed, in Grou-
ven's case of pemphigus vegetans the
lesions at the onset were those of the
common and exfoliating types and only
the subsequent course led to the diag-
nosis of pemphigus vegetans. (26)
Hallopeau and Leredde (27) believe
that the mode of development of
pemphigusvulgari6,aswell as of derma-
titis herpetiformis, differentiates these
matoses complicated by disease of the
mucous membranes and vegetating le-
sions which have led to confusion with
pemphigus vegetans. .The disorder
which Hallopeau regards as the pustular
variety of Neumann's diseaae should,
in all probability, be set aside as a dis-
tinct condition. Its pustular character,
the grouping of the lesions and its
more benign nature (only two of the
five patients died) contrast with the
essentially bullous character and the
hopeless outlook of Neumann's dis-
ease. Tommasolli (28) has persist-
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Pemphigus vegetans— Ham burger— Rubel.
167
ently iDsisted that the term ^'peniphi-
gU8 vegetans" has been used to cover
a multitude of conditions some of
which have no evident relation to
pemphigus. He has proposed to des-
ignate them all as condylomatosis
pemphigoides maligna^ thus abandon-
ing the title of pemphigus vegetans.
This procedure is not justifiable. On
the other hand, there can be no doubt
that as pemphigus vegetans at least two
conditions have been on several occa-
sions described and confused ; the dis-
ease which Neumann distinguished
and another to which Hallopeau's der-
matosis belongs^ a condition character-
ized by vegetations but where the bul-
lous or vesicular lesion is absent or
plays such an insignificant role that
for the present it may be excluded
from the pemphigus group.
The pustular character of impetigo
herpetiformis, too, should differenti-
ate it from pemphigus vegetans. The
frequent association with pregnancy is
an assistance in the diagnosis of im-
petigo herpetiformis as well as in the
recognition of other cutaneous dis-
orders pccurring in this state.
Finally, the rare examples of drug
eruptions, such as Hallopeau (29) de-
scribes as following the use of iodide
of potassium, though combining dis-
ease of the mucous membranes with
cutaneous vegetations, may be distin-
guished by the attendant circumstan-
ces and the subsequent course.
We hate now discussed the diagno-
sis of pemphigus vegetans when the
disease is presented in its entirety.
The superficial resemblance to syphilis
has been emphasized. At the onset,
with the lesions localized in the mouth
and throat, a confusion with lues is
likewise possible and the failure of
antisyphilitic treatment or the appear-
ance of the cutaneous efilorescence
may first indicate the error in diagno-
sis. Seldom, however, does one see
mucous patches so extensive as the in-
itial stomatitis of this variety of
pemphigus, while occasionally, as in
our patient, the occuiTence of intact
vesicles on the mucous membranes,
raises a suspicion of the true nature of
the disorder.
The usual "epidemic stomatitis*' or
'*foot and mouth disease," communi-
cated by cattle, is also accompanied by
a vesicular eruption in the mouth and
fauces, but the demonstration of the
source of infection, the hemorrhagic
tendency of the disease and its usually
favorable course are guides to its recog-
nition.
At rare intervals there are encoun-
tered in adults examples of severe
stomatitis of unknown origin, such as
Mr. Hutchinson has described in the
paper to which we have referred.
These bear, in all probability, no rela-
tion to pemphigus. The possibility of
Neumann's disease should ever be held
in mind and a careful and repeated
search for the ill-omened bulla be
made. Mr. Hutchinson's patients re-
covered under a treatment to be pres-
ently mentioned.
It may be gathered from the fore-
going statements as to the grave nat-
ure of the disease that treatment is
limited to assuaging the suffering of
the patient. General medication is
without effect. Arsenic is valueless,
mercury and iodide of potassium are
harmful. The efforts of Waelsch to
develop a treatment based on a pos-
sible etiological factor are worthy of
note. After isolating the pseudodiph-
theria bacillus from his two cases
and finding that diphtheria antitoxin
apparently immunized animals, he
was led to use the antitoxin on
his second patient as a therapeutic
measure. While the patient was re-
ceiving this treatment, the animals
having survived forty to forty-four
days died, and it became clear that the
protection was temporary or apparent.
The attempt to obtain an antitoxin for
the particular organism under consid-
eration was now made, but the patient
succumbed before the necessary mate-
rial could be gathered.
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Another therapeutic saggestion has
come from Mr. Hutchinson. In those
cases of severe stomatitis which bore
a resemblance to the buccal disorder of
Neumann's disease opium was admin-
istered , and under its use the lesions
healed. But, in no case of undoubted
pemphigus vegetans has opium been
fairly tried at the beginning of the
malady. One is therefore justified in
exhibiting opium in any unusual case
of stomatitis, even before a definite
diagnosis is established.
Although nothing alters the fatal
tendency of the disease, the cutaneous
lesions are favorably influenced and
the discomfort of the sufferer is greatly
diminished by the continuous use of
the full bath. Under this treatment,
the excoriations over the back, neck
and arms of our patient healed and
there was obtained a degree of comfort
which the previous applications of lo-
tions, ointments and powders failed to
give.
The state of the mouth necessitated
the use of liquid and soft food while
rinsing with a hydrogen peroxide wash
was continued.
After all has been said, the nature
of this malady remains obscure. The
prevalent view is that the immediate
cause is some infection or intoxication.
Perhaps subsequent investigation may
prove a causal relation between the
pseudodiphtheria bacilli which Waelsch
and we have isolated and place pemphi-
gus vegetans in the category of infec-
tious diseases. But the disease is not
contagious and in addition to a specific
organism some predisposing factor
must be assumed. With the presence
of an eosinophilia in some cases as a
basis, Leredde. has suggested that a
latent alteration in the hsemopoietic
apparatus predisposes certain individ-
uals to the immediate cause, whatever
it may be. Such an hypothesis is ex-
travagant. Analogy like that offered by
the eosinophilia of trichinosis teaches
that an increase in these cells is the re-
sult of an intoxication or infection and
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offers no evidence as to the previous
state of the blood-forming organs.
History. .
Mr. E. M., farmer, married, age
fifty- two years, was admitted to the
Johns Hopkins Hospital, rn the service
of Dr. Osier, February 6, 1901. He
complained of a skin eruption and sore
mouth.
Family History. — Mother died of
'^consumption." Father died of ''stom-
ach trouble." A sister died of "con-
sumption." A sister is living and
suffers from asthma. Four maternal
aunts have died of "consumption."
There is no history of new growths,
nor is there an account of a trouble
similar to the present in the family.
Past History. — Measles and whoop-
ing-cough as a child. At the age of
twenty to twenty-five, he had a skin
eruption which was said to be due to
"poison oak." Subsequently he had
several attacks.
At twenty-seven years he was over-
come by the heat; since then he has
been susceptible to the sun's rays, hav-
ing on several occasions suffered from
vertigo after exposure.
Ten or twelve years ago he had an
eruption on the wrist ; it itched and was
pronounced eczema.
About five years ago he became
nervous and weak and since then has
not been able to do hard work.
He suffered from shaking chills two
years ago.
Until four years ago he chewed
tobacco a great deal. He has never
smoked to excess. He seldom drinks
beer or whiskey.
He denies all venereal diseases.
Present illness began in January,
1900, with hoarseness. At about this
time he suffered from a sore mouth.
Little ulcers appeared on the lips,
tongue and on the inner surface of the
cheeks. They originated, he asserts,
in little "blisters." Just before the
onset of the sore mouth he had a scabby
eruption on the legs which he attrib-
uted to "red bug bites."
In less than a nionth after the be-
ginning of his illness an eruption com-
menced in the left groin. It was diag-
nosed eczema and under treatn;ient ap-
parently disappeared. Then a similar
eruption appeared in the right groin ;
it itched a little. The same treatment
was used, but it was of no avail and
the disorder reappeared in the left
groin. It gradually grew worse and
spread. It became so bad that the
patient could not move about. The
mouth and throat continued sore at
intervals. In June, he commenced to
expectorate a clear saliva which ran
from the mouth night and day. In
September the disease was called syphi-
lis, and he was given the appropriate
treatment by mouth and by inunctions.
After this treatment the condition of
the mouth gi-ew worse, that of the
groins seemed better. Two weeks ago*
yellow blisters appeared on the arms,
and the condition of the skin over the
back grew worse. This eruption, the
patient states, is entirely different from
the "red bug bites" which were origi-
nally on the legs.
His general condition has become
gradually worse. He has difficulty in
chewing and swallowing. Bowels are
regular. He has lost seventy-five to
eighty pounds in the past twelve
months.
Physical Examination. — The pa-
tient is a sparely nourished man. Mu-
cous membranes are of fairly good
color.
The patient is constantly expectorat-
ing a turbid, foul-smelling, tenacious
sputum. The mouth presents a re-
markable appearance. The vermilion
of the lips is excoriated and irregularly
covered by a whitish pellicle of
macerated epithelium suggesting the
mucous patches of syphilis. The
tongue is covered with a yellowish
white coating. Its dorsum is cracked
and excoriated. Here and there on
careful inspection tiny pin-head sized
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Pemphigus Vegetans— Hamburger-Rubel.
101
vesiclea can be discovered. The mu-
cous membranes of the lips, cheeks
and fauces present the same white
macerated and excoriated appearance
just described.
With the exception of the palms,
soles and scalp, no part of the body
surface is entirely free from lesions.
At the outer canthus of the right eye
there is an excoriation about one cm.
in diameter, the edges of which are
formed by overhanging epidermis
suggesting the remains of a bulla. The
surface is bathed with a purulent fluid.
A dirty brown crust is situated over
the lobule of the right ear and a foul-
smelling purulent discharge exudes
from this external auditory meatus.
The lips are covered with yellow
honeycomb-like crusts. The right
nostril is partly plugged by hard brown
crusts and a discharge of pus comes
from it.
Scattered over the neck, arms,
axillro, flexures of the elbows, fore-
arms, back, abdomen, legs, and groins
the lesions are distributed in various
stages of evolution. The earliest
change is evidently the formation of a
vesicle or bulla. These lesions are
present in the lumbar region, in the
right axilla and flexure of the elbow
and in the right groin. There are
about one-half dozen of them. They
vary in size from that of a lentil to
that of a thumb-nail, are flaccid, dis-
crete and the skin about them is un-
changed. Here and there are bullae of
about the same size which have in
their dependent portions a turbid
yellow fluid.
The greater number of lesions are
excoriations varying in size from about
i to 8 cm. in diameter. They are dis-
crete and confluent. Over the lumbar
region they have come to form a large
irregular patch about 20 by 10 cm. in
size.. The base of these excoriations
is bright red and weeping ; the border
is formed by a ledge of epidermis.
These characteristics are particularly
well marked over the back. Some of
the excoriations, as over the abdomen,
are covered with large yellowish brown
impetigo-like crusts and are surrounded
by a red halo. Scattered among these
lesions are tiny papulo-pustules evi-
dently due to secondary infection.
The inguinal and perigenital regions
are the seat of unusual changes. The
Fig. 6. — This represents one of the papillae
magnified. Here the loose structure of the
stroma is clearly seen. Here and there scat-
tered in the connective tissue are white blood
corpuscles, for the most part polymorpho-
nuclears.
An enlarged capillary filled with blood ex-
tends the whole length of the papilla, and oc-
cupies about one-fourth of its entire width.
One or two layers of columnar cells nre seen
on the surface.
groins are occupied by elevated green-
ish brown, foul-smellmg excrescences
about 10 by 20 cm. in diameter. The
surface is crusted and cracked ; closer
inspection reveals its papillary char-
acter. The same lesion extends along
the lateral aspect of the scrotum and
posteriorly as far as the anus. Iri^eg-
ular patches of pigment are seen on
the shins.
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The nails of the left hand show deep
transverse ridges about their centers.
The lungs exhibit the physical signs
of emphysema; examination of the
heart is negative. The abdominal 'ex-
amination is negative. The sputum
does not contain the tubercle bacillus.
The urine varies in specific gravity
from 1010 to 1020, is acid, contains
neither albumen nor sugar and does
not give the diazo reaction. Micro-
scopically, the sediment shows large
sheets of epithelium.
Examination of the faeces yielded
no noteworthy results.
The blood: hcemoglobin, 85 per
cent. Red blood corpuscles, 4,212,000.
White blood corpuscles, 13,500.
Treatment and Progress of the
Condition.
The patient was given soft and
liquid food and Fowler's solution
m. vi, was administered three times a
day. About two weeks after admis-
sion to the hospital, he was placed in a
tub bath. While under this treatment
the condition of the skin showed an
improvement although fresh lesions
appeared from time to time. Thus,
the left eyelid became involved, there
was a profuse purulent conjunctivitis
but eventually these signs disappeared.
From practically all the excoriations
pigmented papillary excrescences de-
veloped as the healing process took
place. About the neck and over the
upper half of the sternal region, parts
not covered by the water, the excoria-
tions failed to heal. The papillary
growths in the groins were not so
prominent.
The condition of the mouth and
throat varied from time to time, but on
the whole became more and more in-
volved so that even the swallowing of
liquids caused great pain.
The temperature was elevated and
irregular, ranging, as a rule, from 99°
to 97.7°, only on two occasions going
above 102°.
The patient lost weight continually,
became very much emaciated, his mind
wandered, the signs of a broncho-
pneumonia developed on March 10,
1901, and he passed away the follow-
ing day after an illness of about f oi|r-
teen months.
Autopsy.
The privilege of investigating the
brain and spinal cord was withheld.
The autopsy confirmed the diagnosis of
broncho-pneumonia and emphysema.
The condition of the spinal ganglia has
already been noted.
In the anterior mediastinum there
was a firm nodular yellowish white
mass firmly adherent to the peri-
cardium. It measured 18.5 by 7 cm^
On section, the tumor was firm and
gritty. It was found to be lobulated
and composed of a translucent pale
pink tissue striated with fine white
lines. Microscopically, it consisted of
irregular masses of tissue containing-
nuclei closely packed together and
separated by compact strands, often
rounded columns of dense fibrous
tissue relatively poor in fibroblasts..
The former tissue cells possessed nuclei
either of the lymphoid or fibrous tissue
type.
With the exception of the skin and
lungs all other organs were normal.
There was no ulceration in the gastro-
intestinal tract or in the bladder.
Bacteriology.
Cultures taken from the blebs are
either negative or show the presence of
the staphylococcus aureus. Cultures
from the mouth reveal the presence of
a small bacillus in almost pure culture.
In bouillon media it occurs in chains
and groups of two. It is not motile,
stains irregularly, particularly with
Neisser's reagent. There are a num-
ber of irregular forms. It does not
stain by Gram's method.
On agar it forms a moist, greyish
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PEMPHIGUS Vegbtans— Hamburger— RuBEL.
108
white film with abrupt finely serrated
edges.
Gelatine is not liquefied.
No gas is formed in glucose agar.
On potato the growth has a faint
yellowish hue and is moist.
In bouillon there is a heavy floccu-
lent sediment with white particles in
suspension.
Litmus milk shows iio change at the
end of twenty-four hours but in forty-
eight hours it is paler but not coagu-
lated.
The indol reaction is not given.
On October 8, 1901, both a guinea-
pig and a rabbit were inoculated sub-
cutaneously with a sixteen-hour bouil-
lon culture of the organism. The
former received fifteen minims, the
latter twenty-five minims.
The rabbit at the time of inoculation
weighed 850 grms. It steadily lost
flesh after the injection ; on October
26, eighteen days after its inoculation,
it died, weighing 620 grms. At autopsy
nothing abnormal was found except
slight congestion ofthe kidneys, spleen
and liver. Cultures were taken from
the heart's blood and a pure culture of
the organism injected previously was
obtained.
The guinea-pig weighed 230 grms.
on October 8 ; it too, lost flesh steadily
and succumbed on November 1, twen-
ty-four days after inoculation, having
lost eighty grms. On section nothing
abnormal was found. Cultures were
taken from all the organs. From the
heart's blood the original organism
was isolated in pure culture.
The organs of these animals were
carefully examined microscopically
but no lesions were demonstrable.
The organism we were dealing with,
no doubt belongs to the pseudodiphthe-
ria group.
After the death of our patient, the
micrococcus lanceolatus was isolated
from the lungs; a pseudodiphtheria
bacillus from the blood.
REFERENCES.
1. Ueber d. Blasenausschlag oder Pemph ,
Berlin. '^
2. Virchow, Handb. d. Spec. Path, u
Therap., 1S74, 2te Auflage, Bd. III.
8. Ann. des Maladies de la Pean et de la
Syphilis, tome 1, p. 208.
4. N. Y. Med. Jour., 1884, Vol. 39, p. 562.
5. Path, et Trait, d. Malad. d. la Peau (Tra-
duction par Besnier et Doyon), 1891, tome 1,
p. OOlF.
6. Cutaneous Medicine, 1898, Part II, p.
447.
7. Bd. xiii, S 167.
8. Arch. f. Derm. u. Syph., 1869, Bd. 1,
S. 246.
9. Ibid., S. 403.
10. Med. Chir. Trans., 1887, Vol. Ixx, p. 421.
11. Jour, of Cutan. and Genito-Urin. Dis.,
1891. p. 412.
12. Ann. de Derm, et de Syph., 1900, tome
1, p. 1166.
13. Dent. Med. Wochenschr., 1897, S. 267,
14. Deut. Arch. f. Kl. Med., 1894, Bd. 53,
S. 61.
16. Ann. de Derm, et de Syph., 1901, tome
2. p. 869.
16. Arch. f. Derm. u. Syph., 1889, Bd. 1,
S. 71 and 78-100.
17. Ann. de Derm, et de Syph., 1900, tome
1, p. 1161.
18. American Medicine, June 28, 1902, p.
1092. ' » F
19. Arch. f. Derm. u. Syph., 1896, Bd. 36,
S. 141.
20. Die Syphilis d. Haut u. der angren-
zenden Schleimhaeute, 1875, III Lieferung,
Tafel Ixiii u. Ixiv.
21. Loc. cit.
22. Giorn. ital. delle Malat. vener. e della
Pella, 1889.
83. Giorn. ital. delle Malat. vener. e della
Pella, 1898, anno 33, p. 371.
24. For studies on the metabolism see
Stueve, Arch. f. Derm. u. Syph., 1896, Bd. 36,
S. 191, and Giovanni, Gior. ital. delle Malat.
vener. e della Pella, anno 33, 1898, p. 364.
26. Loc. cit.
26. Arch. f. Derm. u. Syph., 1901, Bd. 66,
S. 423.
27. Traite pratique de Dermatologie, 1900,
p. 734.
28. Arch. £. Derm. u. Syph., 1898, Bd. 44,
S. 323.
29. Op. cit., p. 636.
For the treatment of obstinate
cases of ringworm of the general sur-
face, Stelwagon recommends the plan
of painting with a saturated solution
of chrysarobin in chloroform, and cov-
ering with a coating of collodion.
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164
Original Articles.
SPBRMATORRH(EA AS A DISEASE SUI
QBNBRtS.
By J. A. De Ab^ond, M. D., Davenport, Iowa.
When Josh Billings said that he
would rather see a man who did not
know so much than to see one who
knew so many things that were not so,
he voiced a great truth, and its breadth
is such as to include whole sections
and whole societies. The truth of
Josh's philosophy is brough to mind
again by the perusal of an address by
Dr. Sturgis, of New York, delivered
before the Mississippi Valley Medical
Association last year. The doctor
took for his text ''Diagnostic Points
of Difference Between Spermatorrhoea
and Seminal Pollutions." The ad-
dress entire was published in the Amer-
ican Journal of Dermatology for No-
vember. The reader will find the argu-
ment good reading, but for present
consideration the points made em-
phatic by the speaker will do for us.
They were these :
1. Spermatorrhoea is a disease sui
generis.
2. Spermatorrhoea has nothing in
common with pollutions.
3. Spermatorrhoea does not usually
lead to impotence.
4. Pollutions may or may not be
associated with spermatorrhoea.
5. Pollutions are liable to lead to
impotence.
Proposition number one being the
weakest and hardest to swallow, may
as well be considered first. Sper-
matorrhoea has long been a large bear
because nobody would go into the cane-
brake and drive the little runt out.
Irregulars and colicky writers gen-
erally have held the boards, and a bit
of deviation from the normal, unsup-
ported by one single suspicious germ
of bad habits or canying with it a bit
of morbid anatomy worthy of the
name, has gotten the reputation of
being a very bad, dangerous disease.
When you assume that spermatorrhoea
is a disease sui generis^ you give it
a rank and a station which the facts do
not warrant, and by so doing you give
to an airy nothing a local habitation
and a name, and this at the expense of
the truth and in defiance of good judg-
ment. Primarily and as a basic fact
spermaton*hoea is not a disease at all,
and to so class it is to lend aid to a
very disreputable enemy. That it is a
disease sui generis is absurd. Any
disease is a disease sui generis simply
because it has some peculiar character-
istics. The newer and safer nosology
will eliminate a large section of so-
called diseases that hold a place be-
cause they are a little on the sui gen-
eHs order. The sooner we get away
from the idea that spermatorrhoea is a
disease at all, the sooner will we be
prepared to treat and benefit that
large class of the young of both sexes
who have inherited sexual propensities
out of proportion to the ability to con-
trol them. Children born during the
observation and continuance of the
sexual abandon, which legal authority
gives but which wisdom does not en-
dorse, are powerless to control the
sexual fire which is early lighted and
which time alone seems able to quench.
These are the multitudes who furnish
the great army who have the doubtful
distinction of having a disease sui
generis.
Let us for a moment go back to
first principles and see what spermator-
rhoea is, anyway. Gould says it is
** involuntary discharge of semen."
That looks like a very mild sort of sui
generis business to start with, "invol-
untary discharge of semen." Semen
is a complex material, primarily fabri-
cated by the testicles, added to by
glands along the way, and kept in store
in the seminal vesicles. Nature mani-
festly intended to supply a reasonable
demand, and to keep the supply- al-
ways ready. Between the storing
power and the emitting mechanism
there is a very delicate adjustment of
nervous energy. When reasonable
demands for semen are made and at
reasonable intervals, that magnificent
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Spermatorrhoea as a Disease— De Armond.
106
nervous control and adjustment are
beautifully exhibited. When, how-
ever, inordinate demands are made —
inordinate as to time, amount or occa-
sion — ^this fine nervous control is inter-
fered with and the victim of his own
passion secures irregular and unsolic-
ited emissions, and these are sperma-
torrhoea. That does not look like a
very severe form of malady, does it?
In truth, does it look like a malady at
all? If a schoolboy persists in looking
cross-eyed to secure applause, he in
time comes to look cross-eyed when
he has no idea of playing clown ; but
he is miles off from a disease sui gen-
eris.
The victim of his own abuse is
greatly alarmed at the unsolicited
escape during sleep of seminal fluid
and he at once gets busy with the
book which tells him that he has some-
thing sui generis. Sometimes the
alarm is sufficient to cause a cessation
of the abuse, and in that case the pa-
tient at once starts out to find some-
thing which will stop those emissions.
Sometimes the patient is unable to dis-
continue the habit and to his grief is
added the guilty knowledge that if he
does not kill himself nature will make
him impotent, and between the con-
templation of the two possibilities, he
is not in what you would call a satisfied
mind. Here then you have all that
there is to a disease which we are asked
. to consider to be one that is sui generis.
True fear of consequences has driven
countless thousands to drink, to crime,
to suicide, but nowhere do you find
spermatorrhoea recorded as one of the
diseases which is crowding the great
white plague as a destroyer of human
life. It, as a matter of fact, is a fear
and not a disease at all. True, it is
not well to let such conditions go un-
remedied, but life is not threatened by
letting it go. Happiness is sacrificed
by ignoring these patients, but like
that attendant phantom, varicocele,
nature will eventually cure it well
enough to let the victim die of old age
if not of piety. In time these losses
become few and far between, so that
the warning that patients will become'
impotent will rarely materialize if the
patient will let up on his abuse and
take care of himself. Nature may for
a long time continue a habit once thor-
oughly established, but rarely to the
extent of destroying a secreting func-
tion.
So much for spermatorrhoea. Now
comes that bug-bear seminal pollu-
tions. The very name is disgusting as
it means "defilement,** but it really
should be restricted to that condition
wherein masturbation is persisted in
beyond the ability of nature to supply
material for waste. At best it is a rare
state, and many students of sexual
pathology never see a case. It abounds
in asylums, and is found among the
non compos mentis citizenship. It rep-
resents almost complete destruction of
the nervous mechanism controlling the
storing and emitting powers of the
body. Even then it is a mental dis-
ease rather than a physical one in the
sense of a disease. It leads to impo-
tence because it leads to the incapacity
to secure or maintain an erection.
Furthermore such abuse is inimical to
the fabrication of spermatozoa of vital
parts.
Spermatorrhoea has nothing about it
that calls for a sign of impo.tence, ex-
cept in so far as it relates to fear and
the failure, to allow nature time to
fabricate perfect sperm. Spermator-
rhoeics often become impotent because
they let the fear become the fact.
Spermatorrhoea is very far from be-
ing a trivial affair. Its consideration
means much just as its successful treat-
ment means everything to the patients,
but the matter will never be cleared up
any by making a bear out of a bush.
Writers and authors never fail to urge
great effort on the part of the patient,
when, in fact, in thousands of cases
the patient might as well be advised to
stand on his head for a steady job as
to quit a habit which was stamped into
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166
Original Articles
his being as surely and as cruelly as
ever the drink habit was fastened onto
the boy to show .him paradise, and
then lure him to the bottomless pit.
I would not assume that because
spermatorrhoea lacks the essentials of
a disease that therefore it is not a fit
subject for our best study and most
careful attention. But let us put some
of the blame where it all belongs, and
instead of looking for the doubtful
ending of abuse let us raise our pro-
tests against that sanctified abuse
which flourishes so well under the sanc-
tion of law, but which produces a
progeny of helplessness just the same.
It is not only a mistake, but it places
these patients in a wrong light to re-
gard their weakness as depravity,
when as a matter of fact it is depravity
removed a generation or two. This
view of the matter brings to the fore
that other question, which relates to
the treatment of self-abusers before
they have reached the stage of im-
pending or feared impotence. Bight
here is where the treatment means
something, since it gives hope, and
hope is what is ever on the wavering
line with the victims of their own pas-
sion.
Treatment of spermatorrhoea is
always difficult because few patients
can be made to understand that after
abuse it is the rare exception for all
losses to cease. So persistent are the
nocturnal losses, especially, that many
students of sexual pathology have
come to believe that seminal losses
during the adolescent period are nor-
mal. Be this as it may, he who as-
sumes to stop seminal emissions lacks
only the broom to attack the Atlantic
ocean. I am of the opinion that it
were far better to tell a patient that
losses are normal and can no more be
stopped than can the growth of the
hair, and that any treatment looking
toward that end must be useless and
disappointing. Nor is it essential. A
careful scrutiny of the drugs ordinarily
used to control a loss which should be
viewed as a safety valve, will satisfy
most any one that the elements are
offered for greater harm than the
omission of any treatment at all could
possibly do.
At best spermatorrhoea, if honored
by a position in the nosology, is a dis-
ease that does its greatest damage to
the mind. Few bodies are invalided
by it. True, it makes weak men and
unfits them for begetting a race of
athletes, but worse than all it acts as
a barrier to best mental effort, and in
that it robs many a man of the stamp
of genius.
A quarter of a century hence the
literature of sexual matters of our age
will be read as a curiosity, so great
will be the advance in the treatment of
what now is treated by a ready-made
method wholly devoid of reason, sys-
tem or satisfactory results. This,
however, cannot be otherwise until the
haze and glamour and mystery that
have been supposed to envelop the
subject is removed and rational
methods are given a show. When the
reader contemplates that when men
high in the authority on such subjects
present as the result of their labors
the ultimatum scheduled at the begin-
ning of this paper, there is left only
the plain statement that the sperma-
torrhoeic is up against a proposition
which is most unpromising. All these
years the regular profession has been
denouncing the vampires for their
scare methods. Can it be that we
have failed to recognize the actual
facts, or worse still, have we been at
sea without compass or pole star? Or
are we lost and back-tracking it?
We may differ as to some details
and the order of their importance, but
upon one ground we can meet, and that
relates to the place to locate the blame
for a large preponderance of sexual
weakness. Instead of viewing the
hapless victim of an uncontrollable
passion as depraved, let us pity him
as the luckless victim of a load con^^
signed to him by those who kepi
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Prostitution in Japan—Ash mead.
107
within the legal lines, bat gave promi-
nence to a dangerous passion just the
49ame.
PROSTITUTION IN JAPAN.
Bt Albsbt S. Asbmkad, M. D., New York City,
Formerly Physician to the Yoshiwara of Toklo.
The word Yoshiwara means literally
**The Plain of Reeds.'' In the reign
of the Shogun lyemetzu, about 1659,
it was the favorite seat of residence of
the prostitutes. The word Yeddo, the
old name of Tokio (east gate), is
Aino, and means *'Plain." In 1867,
the beginning of the present Meiji era,
the government suppressed the gen-
eral houses, and confined the women
of this class to one quarter of the city.
•** Yoshiwara*' to-day is applied to the
prostitutes' quarter of Tokio. The
gateway of the quarter is shaded by
a high willow tree, the willow of wel-
oome. The licensed houses, Eashiz-
ashiki, are all under regular medical
attendance. The examinations are en-
forced once a week, and are controlled
by a special policeman.
A girl applying for license) as a pros-
titute is severely questioned by a chief
of the Yoshiwara police. ' She is
usually accompanied by a parent or
other guardian. When a girl is
forced by her parents, or of her own
free will desires to become a **lady of
pleasure," a sum of money usually
passes in the way of contract, say
<10 to $50^ sometimes even more.
No Yoshiwara woman is allowed to go
out of the district without a special
pass, and accompanied by her maid or
a relative. Physical examination of
the girl takes place once in ^^itchi-
roku" (a Japanese week), usually the
•day following the holiday, or, as we
would say, Sunday. Those who are
found to be diseased are sent to the
special city hospital, which was mine
while I lived in Tokio. The inmates
of the prrtstitute bouses are doubly
taxed, by the government and by the
bawdy house keeper. The govern-
ment taxes the owner of the property
$5 a month and each prostitute $2
a month. The restaurant keeper is
charged $3. The terms applied
to the girls engaged in this oc-
cupation are: Orian, politest term;
shogi, common; joro, opprobrious and
severe; and yujo, **fille de joie," the
tenderest or prettiest. Some of the
rooms (each one has her own) are
charmingly decorated and adorned
with screens, carvings, chinaware and
lacquer. Sometimes the wall exhibits
some Kakemono, with appropriate
poetry, as Matsu kiku, nao, sonsu,
literally, **pine chrysanthenjums still
are," that is the pine and chrysanthe-
mums always preserve their charm,
even in winter, when other flowers
die, and by implication, *'My charms
are everlasting, like the pine and the
chrysanthemum ."
Prostitution in Japan is considered
to be an ineffaceable stain on the indi-
vidual and an irremediable lowering of
dignity; and yet they believe that
there are some cases in which it leaves
the moral character untouched. For
were not the noble women of the Taira
family once captured and forced to be
prostitutes, and did not men who
were not noble seek wives from the
Yoshiwara, on this account, ever
afterward, to put noble blopd in their
offspring's veins ? Of the famous and
beaiitiful harlot, Murasaki it was
said, **She defiled her body, but not
her heart." And she was described
as **a lotus in the mud." Hence
many prostitutes look forward to re-
spectable marriage as a possibility of
escape from their shame. But these
cases are rare. The female footprints
in the Yoshiwara nearly all point one
way. When once one becomes an in-
mate she remains till disability or death.
Poverty and natural inclination are the
determining causes that recruit the
ranks of the joro. A Japanese
proverb says: **Once get into dirty
water and you will never be washed
clean again as long as you live."
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168
Original Articles,
(Ichido doro midsu nihai&ra, issho
mi wo arayenai.) This applies to
these women of the Yoshiwara. Some
few get married. Occasionally one
will commit suicide. Others desoend^
through becoming ugly or old, to the
position of servants in the house where
formerly they were ornaments.
Among the '♦lotuses of the mud**
there is a great deal of romance.
Novels by the hundreds tell the
stories of the denizens of the Yoshi-
wara, of their beauty, their misfor-
tunes, goodness, triumphs, happiness,
or despair and suicide. As was said
in Palestine long ago, there are often
more virtues to be found in the harlot
class than among the ♦ 'highly respect-
able." This is as true of Japan as
it was of Jerusalem.
^*
PROSTATIC SURQERY^HiSTORiCAL
AND EXPERIMENTAL*
Bt BXNJAMlK Merbill Rickbtts, Ph. B., M. D.,
Cincinnati. Ohio.
Anatomy. — Two lateral and a mid-
dle lobe constitute the prostate, which
was first described by Hume, 1806.
The gland is not constant and is of
many variations.
Normally it is about one and one-
half to two inches in its transverse di-
ameter; one inch antero-posterior di-
ameter, and one inch in depth.
It is composed of Cowper's glands
(each the size of a pea); numerous
follicles and muscular tissue arranged
to form about twenty channels lined
with columnar epithelium (excretory
ducts) through which a milky, slightly
acid fluid passes to dilute the semen.
All vertebrates fecundate in the same
way.
Blood supply is from the internal
pudic artery.
The venous blood enters the internal
iliac vein through the dorsal vein.
Nerve supply is from the hypogas-
tric plexus and the filaments of the
sympathetic.
* Abstract. Bead before Ohio State Med. Socy., Jane
5, 1903, Dayton, Ohio.
Etiology. — Man is the only animal
that has hypertrophy of prostate. No
definite cause yet assigned; habits,,
disease and evolutionary changes from
quadrupedal to bipedal state, probably
the most important factor.
"Prostatic hypertrophy not found in
Japan, India or China." (Otis.)
Surgery of Prostate. — Ammonium
Lithotomus, B. C, 460-357; John-
nesde Romanes, 1555 ; Ran of Leydon
and Frere Jean, 1700, in operating for
stone no doubt contributed much ta
advance the various subsequent opera-
tions for prostatic hypertrophy.
Cystotomy may be said to have been
inaugurated when the bladder was first
opened for any purpose. Both peri-
neal and suprapubic drainage have been
successfully accomplished with more
or less benefit in hypertrophy of the
prostate.
Massage was first employed by Est-
lander, 1878; Hogge claimed priority
in the use of electrical massage.
Lewis, 1899, employed the finger
and condemned instruments for this
purpose.
Neiswanger, 1900, employed cata-
phoric applications of iodine in hyper-
trophy of prostate.
Injection of various solutions, argentt
nitras, iodine and cocaine, into the
prostate was done by Hall, 1887; no
special effect.
Heurate, 1896, injected testicular
extracts into the prostate.
' Ligation of cord was done by Mears,
1894, without effect.
Ligation of iliac arteries was done
by Bier, 1893, and Meyer, 1894, while
Loze, 1898, removed the venus plexus
(veico).
Vasectomy was employed by Lou-
mean, 1895, since which time there
have been several hundred such op-
erations.
Sleinach, 1896, showed by experi-
ments on rats that the removal of the
seminal vesicles and prostate gland
does not lessen the sexual passion or
ability to perform the sexual act, with
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Prostatic Surcery—Ricketts.
lOO
« discharge of spermatozoon, but that
fertilization is prevented.
The ability of the semen to fertilize
is lessened by the removal of their vesi-
•cles.
The operation of vasectomy has be-
come obsolete.
Castration was first performed for
prostatic hypertrophy by Mercier,
1857, but was pot again performed
until White, Ramm and Cobat, 1893,
did it.
Removal of one testicle is supposed
to cause its corresponding prostatic
lobe to undergo atrophic changes,
while the removal of both testicles
will cause atrophy of all the lobes.
The operation was based upon the
fact that eunuchs do not have prostatic
hypertrophy.
Several hundred cases of prostatic
hypertrophy have been subjected to
emasculation with more or less benefit.
It should be done in but a few se-
lected cases, such as extreme age or
lessening of vitality, or before more
radical measures.
The operation is seldom considered
since the inauguration of prostatect-
omy.
Prostatotomy coni^\st8 in incising the
prostate by knife, cautery or other-
wise, for abscess, cysts, foreign bod-
ies, injuries or pathologic conditions.
Tenotomj/ of Levator prostate was
first done by Wyman, I880, and again
by Andrews, 1902, with much benefi-
cial result.
Urethral Prostatotomy. — Incising
the prostate through the urethra by
knife, catheter and various other de-
vices dates from Home, 1817, since
which time many such operations have
been done by as many different de-
vices. Much benefit has been obtained
from this method, but it is no longer
considered rational.
GffJvanO' Cautery has been employed
since 1875, when Rabitsch and Bottini
reported the result of their work.
The cautery was very seductive and
attended by much mortality and un-;-
certainty in its results.
It is applicable (if at all) in but a
few cases of a selected type.
It cannot be considered a rational
procedure, as the cautery cannot be
seen.
Perineal Prostatectomy is the re-
moval of a part or all of the prostate
gland through a median, transverse or
lateral perineal incision.
Gibb's question, 1857, was, ''Can-
not enlargement of the middle lobe of
the prostate gland be removed by the
lateral operation* for lithotomy?"
This is one of the earliest suggestions
for the removal of the prostate gland
through a perineal incision.
Since this time many such opera-
tions have been made for this purpose,
and there can now be no question as
to this route and method being the
most acceptable and beneficial opera-
tion for hypertrophied prostate.
Rectum for Urinary Receptacle. —
Ricketts, 1902, in removing the pros-
tate gland in two cases of emergency
succeeded in diverting the urine into
the rectum.
During the last century there have
been several cases reported in which
the vagina was closed by an operation,
that the urine might escape into the
rectum for the relief of vesico-vaginal
fistula.
Prostatectomy ( Suprapubic) . — Only
a part of one or more prostatic lobes
can be removed by this method.
Usually complete removal of the lobe
is confined to the ^ middle lobe, for
which it was first intended.
Roonhysen, in cutting on the gripe
or with grooved sound and gorget,
found it impracticable, and the supra-
pubic operation for stone, which was
probably one of the first suprapubic
operations, was resorted to.
Lisrink, 1882, was one of the first to
remove the prostate gland suprapubic-
ally, since which time many such
operations have been made for pros-
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170
Original Articles.
tatic hypertrophy with great success.
Of all operations for hypertrophied
prostate the perineal and suprapubic
operations remain supreme in their re-
spective order.
Prostatectomy (Perineal and Su-
prapubic Combined). — The combined
operation has many advantages in a
certain class of cases of prostatic hy-
pertrophy. However, since the many
prostatic retractors have been de-
vised there is not the necessity for
entering the bladder suprapubically.
Fuller, 1895, removed the prostate
gland and drained through the perineum
and suprapubically.
Abscess of prostate is common and
more frequently due to cysts, gonor-
rhea and trauma, usually gonorrhea.
Most frequent way of escape is into
the rectum.
Tuberculosis seldom originates in the
glandular tissue, primary disease be-
ing rare in the prostate.
It is usually secondary and may in-
volve a part or all of one or more
lobes. It was first described by
Louis.
Complete removal of the disease can
be made and should be done.
Echinococci, most common parasite
found in the prostate gland, usually of
primary origin.
The cyst usually ruptures into the
bladder or rectum, in which case spon-
taneous recovery will ensue. If into
the peritoneal cavity death may result
or the parasites may become encysted
and remain harmless indefinitely.
Calculi form in the prostatic ducts,
and may be discharged into the urethra
or remain in the prostate to become
encysted.
Fuller, 1900, reports such a stone
weighing three ounces.
Carcinoma of the prostate is more
frequent in childhood, and beyond the
age of 50, primary or secondary,
usually the latter. Often in the civ-
ilized races, and originates, as a rule,
in the mucosa of the prostatic urethra.
No treatment, surgical or otherwise^
is at present of any avail.
Beling, 1822, records an interesting
case of prostatic carcinoma.
Sarcoma of the prostate is usually
hard and of slow growth, originating^
in the cortical substance.
More frequently found in the young.
No hemorrhage except in advanced
growths. May be primary or secondary,,
usually primary.
London Lancet ^ 1853, i, 473, men-
tions a case of sarcoma of the prostate.
Early removal should be done, as it
is the only hope.
if
SYPHILIS OP THE NERVOUS SYSTEM.
Bt Fbank £. Coulter. M. D., Omaha. Nebraska.
No portion of the nervous system
can be considered entirely exempt
from the ravages of syphilis. Hen-
schen quotes figures from which we
are safe in concluding that one at
least in every seven infected by syph-
ilis, develops some lesion of his nerv-
ous organization. The preceding
statements afford all the apology we
have to offer for the present paper*
Syphilis too often remains unrecog-
nized until the period for relief is
passed. In this disease especially^
even more than in many others, if we
would be successful in the treatment^
an early recognition of the condition
is absolutely essential. On this point
we think all will unite.
Upon careful reflection the conclu-
sion is reached that syphilis, as an
etiological factor of disease in this
country, is not recognized as fre-
quently as it should be; we in this
western portion especially have too
exalted a conception of our own virtue.
This false modesty frequently ham-
pers us in obtaining a true history of
infection from this disease. As a re-
sult of investigations, both remote and
recent, it seems most probable that
this disease is due to a micro-organ-
ism ; if definitely isolated at the pres-
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Syphilis of the Nervous System— Coulter.
171
ent time or not, there still seems to
be some question.
Let us, then, consider the earliest
etiological factor of the trouble — the
question of, or subjection to, or liabil-
ity of infection. All will agree that
outside of a few rare cases, that are
mostly conGned to the medical pro-
fession, there is but one method by
which the disease is propagated. Sir
Wm. Gowers has most aptly stated
that no patient should be considered
absolutely free from syphilis unless he
has never been exposed. This, how-
ever, does not apply to the members
of the medical profession. Some may
consider his statement entirely too
broad, but when you come to ponder
it carefully you will conclude, we
think, that it is true. The point of
infection is readily concealed or over-
looked, so that many of these patients
do state the truth so far as they know
it when they tell us that, to the best
of their knowledge, they never were
infected.
Let us ever remember there is no
word in the English language descrip-
tive of the virtuous man, the counter-
part, of "virgin" as applied to the
female. Many cases of an undoubted
syphilitic nature have developed in the
nervous system, as well as in other
locations, when the patient has posi-
tively and honestly, as he believes,
never suffered from the initial lesion
of syphilis. If such cases are prop-
erly questioned many will admit gon-
orrhoea, many others will say they had
a *'8oft chancre'* or some other so-
called unimportant lesion, a few will
say they had the ''classical Hunteriati
sore," while but very few will tell you
they never were exposed.
A very few men and some women
run the gauntlet for a time when vis-
iting the shrine of Venus and are never
entrapped; others, and it is no small
per cent., make the journey and are
entrapped, but do not truly recognize
this fact; still another class, and they
are not the majority, have been
"unfortunate" and realize as well as
acknowledge their condition.
While we believe our patients do
not as often try to deceive us in these
matters as we sometimes think, yet it
is our duty to drive these questions
home when soliciting the history, for
the benefit of all concerned. There
are recognized a number of contrib-
uting factors that serve to bring to the
surface, as it were, syphilitic manifes-
tations. A few may be mentioned — as
trauma, mental or physical overexer-
tion, sexual excess, ^strong emotions,
alcoholism and exposure; these only
serve, however, to bring out the re-
sults of the infection already so well
inaugurated. Alcoholism seems to be
one of the most, if not the most potent
of these factors. Because of another
paper prepared for this society, in-
herited syphilis and its relations to the
nervous system will not be considered.
Morbid Anatomy and Pathology. —
For the sake of convenience the old
familiar terms, primary, secondary
and tertiary, will not be adhered to,
but instead the entire manifestations
of this disease as found involving the
nervous system will be divided into
the early and late changes, and some-
times are designated as specific and
parasyphilitic.
The terms early and late, of course,
are only relative at best; so are pri-
mary, secondary and tertiary, for that
matter, as are many terms used in
medicine. It would seem that after a
period of ten or twelve years in the
majority of cases the results of the
specific infection of syphilis undergo
an alteration. Why this is the case
we are at a loss to understand, unless
the active force of the disease is ex-
pended by that time; anyhow, it does
not yet seem to have been satisfacto-
rily explained, but the clinical picture
observed after the period just men-
tioned is much changed from what is
seen before that time; this is not an
infallible rule, but a frequent fact.
In this connection it may be of inter-
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est to know that about forty-four per
cent, of all syphilitic intracranial le-
sions develop within the first three
years of infection, that about fifty-nine
per cent, develop within the first five
years, and in rare* instances a definite
syphilitic cerebral lesion has developed
while the initial hard chancre was still
in existence. Many of the cord lesions
of an acute nature also become mani-
fest during this early period. This is
food for thought for those who do not
believe that results follow the infec-
tion swift and definite.
Under the head of the early or spe-
cific manifestations may be mentioned
the vascular lesions, endarteritis,
thrombosis, gummatous formations,
meningo-encephalic inflammations,
etc., then we have a rare form of waxy
degeneration of the middle coat of the
arteries occurring in syphilis. Athe-
roma may be of a syphilitic nature, but
more frequently is simply degenera-
tive. The later changes are those
which usually become manifest after
ten or twelve years from the date of
infection and are the degenerations
and sclerosis, the principal representa-
tive in the encephalon being general
paralysis of the insane, the so-called
softening or paresis, and while paresis
occurs in other than syphilitic patients,
yet there is no doubt that syphilis is
one of the most prominent etiological
factors of this disease; in the cord,
posterior sclerosis is the representative.
To return to the lesions enumerated as
occurring in the earlier stage of the
disease, they may be classed according
to structures involved: 1st, those of
the blood vessels; 2d, those of the
brain cord and its membranes; 3d,
the formation of new growths known
as gummata.
The chief vascular alteration is oblit-
erating endarteritis, yet this is not now
considered as strictly pathognomonic
of syphilis, as it once was; it results in
thrombosis and softening, or if only a
partial obliteration obtains, sclerosis or
hardening may be found in either the
encephalon or cord. Any of the cord
or intra-cram'al arteries may be the
seat of these alterations, but the verte-
brals, the basilar and mid-cerebrals are
most likely to suffer, hence symptoms
must vary according to the particular
artery involved. The cerebral corte"i
and membranes, one or both, are not
infrequently the seat cff inflammatory
action, and if the vertex be involved
the symptoms will differ from those
present when the base is the seat of
operations. Gummata may be found
either on the vertex or the base, or
both, these bein^ the most usual loca-
tions, very seldom in the interior.
Sometimes these may be very diffuse in
character, in others they are circum-
scribed. They vary in size from a
millet seed to a walnut, and often are
multiple. Some writers believe that
acute simple inflammation of the cord
seldom if ever exists, but that the con-
ditions described as such are those of
multiple thrombosis of the capillaries,
and certainly t;he anatomical arrange-
ment of these vessels would support
the theory.
Symptoms. — The symptoms pro-
duced by a specific vascular lesion in
the encephalon, or cord, are not essen-
tially different from those produced by
any other like lesion ; that is, a throm-
bosis due to syphilis is not essentially
different from a thrombosis due to
some other cause, granted that in both
instances it is complete; and the same
may be said of hemorrhage or em-
bolism; this refers to the early clin-
ical phenomena only, remember. The
same statement may be made and holds
good regarding inflammations and
gummata, but not to quite the same
extent. You naturally ask the ques-
tion, if the statements just made be
true, how are we to make a diagnosis
of syphilis, how may we be positive we
are dealing with a syphilitic manifesta-
tion at all? The following rules, if
observed, will direct you in the diag-
nosis. You will observe in these cases:
1st, a peculiar association or succession
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Syphilis of the Nervous System— Coulter.
178
of symptoms that indicate a double or
multiple lesion; 2d, a most unusual
tendency to remissions and relapses;
^d, the onset of the case is usually
sudden rather than acute, and the
•course is sub-acute or sub-chronic
rather than chronic; 4th, symptoms
as a rule resolve rapidly under appro-
priate treatment, but not always. You
will thus observe that there is a pecu-
liar grouping of symptoms that is not
found in any other disease and is char-
-acteristic only of syphilis.
The most frequent vascular lesion
found in syphilis of the nervous sys-
tem is thrombosis, and you will at
-once understand, as has been stated,
the symptoms vary depending upon
the particular vessel affected, and it
would be interesting in this connection
to follow these out in the case of each
•of the vessels named had we sufficient
time. As has already been indicated,
i:he pathological changes are often
incomplete, hence the symptoms are
in such cases more or less transient
and indefinite in character. This ex-
plains a hemiplegia that often makes
apparently a good recovery, also an
^aphasia that is transient, verbal am-
nesia, parasthesia, lapses of conscious-
ness that are fleeting, temporary men-
tal confusions, etc., which accompany
the condition. Usually the patient ex-
periences a warning, such as headache,
vertigo, transient numbness, or loss of
power before the full force of the at-
tack is experienced. Just here if you
zare able to diagnose the condition your'
skill will be of the utmost value.
Within a few months a lady was
•brought to my office having rapidly
and within a few hours experienced a
loss of power in the left forearm, hand
^nd fingers, the member being limp
-and flaccid to such an extent that she
-could not use it only to a limited de-
-gree. There was also experienced a
sensation of fullness and burning in
the member, as if it would burst. This
•condition had been preceded several
liours by headache ; but no nausea, no
unconsciousness, no convulsions, local
or general. She was twenty-five years
of age, and having positive evidence of
syphilitic infection four years before,
we were able to at once diagnose the
situation as a commencing thrombosis
of the second branch of the right mid-
cerebral. Nitroglycerine and strych-
nine were prescribed every three
hours, and potassium iodide three times
a day, and the results were that within
three days all symptoms of the im-
pending paralysis had disappeared, the
strength also returning. This case is
only one out of many of a like charac-
ter that could be related.
Hemorrhage and embolism do not
frequently occur as the result of syphi-
lis; hence, we will not take the time
to consider them here; but if they
should occur,the same diagnostic points
should be observed as would differ-
entiate these conditions were the cause
other than syphilis, remembering that
hemorrhage and thrombosis are very
different conditions, and require en-
tirely different management. As to
gummata, these productions are often
multiple, they may be circumscribed
or diffuse, and as stated are found
most frequently on convex (external
surface) or on the base. Headache is
a common symptom, worse at night
usually; then again convulsive attacks,
general or localized, often appear.
Vertigo and vomiting may be present.
Weakness manifest in some group of
muscles is often found. Optic neuritis
is present in a large number of cases.
If the gumma is located at the base,
some of the twelve pairs of cranial
nerves are most likely to suffer in com-
plication from the third down; the
sixth because of its length and location
is found most frequently involved, but
it is of poor diagnostic value as a
localizing sign (Russell). Memory is
often bad and mental confusions usu-
ally exist. Aphasia in some of its
various forms often is present. Under
certain conditions the gumma is more
or less diffuse, then the localizing signs
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are less definite. The membranes may
become involved as well as the cortex,
when more or less of an inflammatory
condition will be found present. In
such a case much depends upon loca-
tion and the general evidence of men-
ingitis in combination with an enceph-
alitis, the symptoms may be more or
less acute, hence the picture you will
study may vary. Polyuria and poly-
dipsia may be present. Ptosis, di-
plopiaor someform of external ophthal-
moplegia or bilateral heminopia or an
internal ophthalmoplegia may be en-
countered. These eye symptoms are
peculiarly charact^stic in that they
are often fugitive, present today and
absent tomorrow, or at most lasting
but a few weeks. The ophthalmoscope
shows changes in the fundus in about
40 per cent, of the cases. It may be
an optic atrophy, chocked disc, or a
retinitis. Hereditary syphilis may
often be demonstrated by some of the
above signs, and in these congenital
cases a partial inhibition of mental de-
velopment is prominent.
Diagnosis. — It would seem almost
useless to say anything more on the
question of diagnosis, other than what
has just been mentioned in the symp-
toms, but that particular part of the
subject is so important that perhaps a
few more words may not be entirely
useless. One of the most important
questions is, first, the history of ex-
posure, but this is not absolutely es-
sential, as we have seen, for the dis-
ease will tell its own story generally ;
second, if your patient is suffering
from intra-cranial syphilis, he will
most likely show some other evidence
of the disease, yet this is not absolutely
certain. Always look for the sore
throat, mucous patches, glandular
enlargement, patches of characteristic
discoloration of the integument, etc.
If the patient be married, note care-
fully the history of any miscarriages.
See if the pupils are equal in size and
regular in contour; this is a most im-
portant point. Also note the Argyle-
Robertson reaction, if present .
Of the early syphilitic manifesta-
tions in the cord, a so-called trans-
verse myelitis is most frequently en-
countered, or the myelitis may be dis-
semitiated ; another most frequent cord
condition is a meningitis that may be
localized or general, and subacute or
chronic in character. Tabes is con-
sidered by most authors one of the
parasyphilitic manifestations usually,,
the per cent, varying according to the
experience of each observer.
Patrick has given the following
points between general paresis and
cerebral syphilis. He says: "When
the symptoms appear at a remote
period, say ten years after infection,
the disease is probably paresis, cere-
bral syphilis usually appearing before
ten years, In paresis usually the higher
mental faculties and operations are
first attacked ; those of a purely routine
nature are last to suffer. In cerebral
syphilis these symptoms are usually
somatic, as paralysis in various situa-
tions, usually focal, sensory disturb--
ances, etc. ; therefore in cerebral
syphilis there are apt to be symptoms
added to the clinical picture that are
not usual in paresis. "
Severe headache is generally pres-
ent in syphilis, but absent in paresis.
Pains in other parts of the body, worse
at night, stand for syphilis rather than
paresis. Marked anesthesia or pares-
thesia would indicate syphilis. Paraly-
sis of any of the cranial nerves below
the third will indicate syphilis instead
of paresis, hence external ophthalmo-
plegia would mean syphilis, while
internal may or may not. TheArgyle
Robertson pupil may mean either
syphilis or paresis. Physical weak-
ness and tremor, if general, would in-
dicate paresis, while if local would be
more in favor of syphilis. Primary
optic atrophy would indicate paresis,.,
while optic neuritis or secondary
atrophy would indicate syphilis." Now,.
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SyPH!LIS OF THE MERVOUS SYSTEM—COULTER.
X76.
these differential points are interesting
when one remembers that some au-
thorities place syphilis as the etiological
factor in paresis as high as 75 to 85
per cent., but from a practical stand-
point, however, if the statement just
made be true, it is not of much impor-
tance in the treatment.
Prognosis. — There is probably no
condition where a prognosis is more
valuable than in the one we have under
consideration, but at the same time it
may be most faulty. Two points
should not be omitted in this con-
nection : first, it is a mistake to sup-
pose that all syphilitic lesions of the
cord or brain will recover under ap-
propriate treatment. This fallacy has
permeated the profession pretty thor-
oughly and should at once be removed.
An artery that has once been perma-
nently closed by a syphilitic throm-
bosis will remain so in spite of all the
mercury or iodides in the world, just
the same as if the condition was caused
by some other disease. The same
holds true of the other vascular lesions.
A gumma may be absorbed or become
stationary, but a cicatrix of a more or
less irritative character remains. The
second point well to remember is that
it is the very nature of this disease to
have remissions and relapses; patients
are ''up and down," and these hopes
are often an ig?iis fatus following
which a reputation may perish and a
valuable life be lost.
Turner makes the statement that 30
to 35 per cent, of cerebral syphilis re-
cover, that about 12 per cent, are fatal
and soon die, while the remainder, 53
to 58 per cent., over half, you will
note, are more or less permanently
maimed. No doubt these cases em-
brace the most unfavorable of all cases
and have most probably been taken
from hospital practice, where those
who are most likely to be past help
will appear, for a hospital is not
usually sought unless something serious
has transpired. In the early mani-
festation of the condition, and we
mean by this when the patient com-
mences to manifest some of the pre-
monitory signs, already referred to.^
then if recognized a more hopeful
prognosis may be ventured, other
things being satisfactory. As to the
cord troubles, it would seem that the
figures mentioned are to optimistic.
In summing up the prognosis one can
say, if recognized early and appropri-
ate treatment instituted, much benefit
may be expected and often an apparent
cure result ; hence the very great im-
portance of an early, careful and ac-
curate diagnosis. If later manifesta-
tions are encountered, less improve-
ment is probable, but considerable
benefit may be derived. If the very
late manifestations are found the im- .
provement will be but little, and if the
progress of \ he disease is stayed it is
perhaps about all that can be expected in
many cases. Above all, remember that
each case demands individual and care-
ful study and that a prognosis must
depend upon the mtelligent interpreta-
tion of the facts thus obtained, based
upon the conditions present.
Treatment. — Just a few words on
the very important question of treat-
ment. When the evidence is all col-
lected it will be found that many cases
of syphilis, of the nervous system, and
of other organs as well, have been
allowed to perish and have been taking
mercury or the iodides much of the
time. The fault does not reside in the
remedies, but in the method of admin-
istration. Many patients are drugged
to death by these remedies who would
have been saved by an intelligent ex-
hibition of the very same remedies.
As to the remedies themselves, the two
just mentioned are the only ones
worthy of consideration in the treat-
ment of syphilis. How should they
be given, and when ? are most pertinent
questions.
Unfortunately the leaders in neuro-
logical work of today differ as to the
size of the dose and the length of the
time treatment should be continued;
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176
Original Articles.
however, personally, the method of
<jrowers would seem most satisfactory.
Perhaps that is because we are the
more familiar with it. So far as in-
flammations are concerned, he rather
believes that they are best controlled
by mercury, while gummata are pos-
sibly better controlled by iodides, or
at least as readily controlled by them
as by any remedy. In the Lettsomian
lectures, he makes this statement: ^^I
am inclined to think that when a lesion
is distinctly influenced by either drug
(referring to mercury and the iodides),
if this is given freely the effect, of one
is as great as the other." In his hos-
pital practice, in many instances, it is
his custom to first give mercury until
the physiological effects are estab-
lished; then follow with the iodides.
He does not sanction, but discourages,
the large dose and long-continued use
of the latter drug as given in this
-country, and fortifies his position by
pathological findings that would seem
<3onclusive and incontrovertible. The
theory advocated is that the tissues be-
come accustomed eventually to the
remedy in large doses and that in cer-
tain eases syphilitic lesions are not
-controlled as they are when the remedy
is first administered; hence a moderate
dose, ten to fifteen grains of the
iodides, three or four times daily, and
continued for from six to ten weeks
only, then an interval is allowed and
the treatment is resumed later. The
two remedies are not usually given at
the same time, unless a very rapid
action is desired, the reason given be-
ing that the iodide eliminates the
mercury before its full effects are ob-
tained. Many methods of adminis-
tering mercury have been used, but
inunctions, and by the mouth have
proven the best for all-around work.
In certain cases other methods may be
tried perhaps with advantage; such as
the hypodermic, fumigations, etc.
Baths are not to be forgotten in th e treat-
ment of this condition, and waters of
a sulphurous nature are especially ad-
vantageous in assisting in the elimina-
tion.
We purposely because of time limi-
tation have not discussed the questions,
**Can syphilis be cured, and is it a
self-limited disease?" Much can be
said pro and con upon this subject, and
it is suflSciently broad of itself to
furnish material for a paper more
voluminous than the present one,
hence we crave your indulgence be-
cause of our inability to call your at-
tention to but a very few of the
important points in connection with
this most interesting subject.
REFERENCES.
Oppenheim.
Brain. Aatamn number, 1902.
Allchin, Manual of Medicine, yol. iii.
J. Rissian Russell, Clinical Lectures, 1901.
Gowers* Manual of Nervous Diseases.
Lettsomian Lectures, Gowers.
Diseases of Nervous System, 3rd Edition,
Gowers and Taylof .
A SIMPLE REMEDY FOR THE CURE OF
VARICOCELE.
By Frank A. Bbkwer, Sb., M. D., King City, California.
In my late article relating to this
subject, written for the Pacific Medical
Journal^ in which I endeavored to show
that a more rapid cure of varicocele
was possible through an improvement
of the '* Morgan Method," the motive
sought was to increase an interest upon
the part of the medical profession at
large, if possible, in the great crying
needs of humanity for the relief of
genito-urinary lesions, which in real-
ity have assumed an epidemic form!
There is no mistaking this fact, as
the late records of the army and navy
indicate in their examinations of ap-
plicants for service in the Cuban and
Philippine wars, where over 68 per
cent.' of cases were rejected owing to
the presence of varicocele.
A specialist in these diseases has
lately published a statement to the
effect that he has found that fully 95
per cent, of the male sex are afflicted
with this maladv.
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Cure of Varicocele— Brewer.
177
Why? My reader, at that rate it
will not be loDg before the American
Nation must call upon some more nor-
mal foreign human elements to come
to its rescue, if not sooner relieved.
Hence, the duty of proffered assist-
ance in the reduction of this increas-
ing affliction becomes an imperative
one upon the part of the medicos in
general, instead of leaving it to the
specialist, as is now the case, many of
which are mere frauds, and others
charging most exorbitant rates !
No doubt many of our medicos dis-
dulged by spec
tried, but were
lieving.
Becoming lat
** Morgan Meth<
with more satisi
Finding that
ble of improven
cure might foil
vent an outfit tt
both testes, bi
unaffected orga
mal nourishmen
Morgan Metho<
/^ (r/
•▼r^r-flc^^"
^»» • x'S^
like to add this specialty to their prac-
tice, owing to an imaginary idea of a
redundancy of ''gonorrheal taint," but
several specialists have informed me
that not over one per cent, are thus
affected.
Certainly there can be no objection
in a remunerative point of view, as
this disease is no respecter of person,
affecting both the rich as well as the
poor alike, and up to date the spe-
cialist is having it all his own way and
doing a lucrative business.
In my late article in the Pacific Med-
ical Journal I referred to an accident
happening to myself, that of receiving
a kick from a brother-in-law at my
back, while poised in a squatting posi-
tion upon the floor of my office, the
blow striking my left testis, ruptur-
ing some of its vessels and disorganiz-
ing its entirety, resulting in a true
varicocele.
The usual forms of remedies in-
versible poise, t
and confinemen
sacular investm
A single susp
Irish linen waf
with same kinc
inches in lengtl
were attached
with a oorrespo
lets along its op
Upon one enc
were fastened ;
(Irish linen) v
ficiently long c
suspensory at it
of the penis, >
pension.
A body bell
structed having
end, and as well
of about four
tached to it, th<
the left of the j
the body, so as
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178
Original Articles.
the testis within the groin and prevent
its roUingt towards the median line and
becoming injured.
Upon the ends of each tape were
fastened an eyelet for the support of
the testis.
The form of the suspensory and the
belt are here exhibited, the suspensory
being flattened out in order to give a
•better idea of its form.
This suspensory was sized to em-
braced the testis and scrotal integu-
ment more or less tightly, but not suf-
ficient to inflame the tissue, but enough
to prevent an escape from the mouth
of the suspensory orifice ; at the same
time care was fully observed to avoid
irritation in the tying process until
nature became accustomed to the in-
terference.
The scrotal tissue was at first en-
•couraged to a laxity by an ablution of
quite warm water, then dried with a
soft towel.
The left portion of the scrotum,
including the left testis, was then
seized with the fingers and thumb of
the right hand and elevated to a per-
pendicular poise.
With the fingers and thumb of the
left hand embracing both «ides of the
scrotum and testis a gentle pressure
was applied, and a sliding motion to-
wards the body followed, by which the
overcharged .vessels of the testis were
relieved of their stagnant fluids, the
same were forced into the greater cir-
culation, and a fresh supply of blood
encouraged in substitution.
This motion was similar to that of a
milker when stripping the teat of his
oow.
Still holding the tissue at its per-
pendicular the single suspensory was
applied, and hooks fastened to the
eyes, then carried on upward and at-
tached to the tape eyelets of the body
belt, previously placed in position,
und the opposite end was fastened to
the base of the penis (not too tight at
the beginning).
The clamp was then attached to the
outer third of the scrotal tissue and
also lip of suspensory, the purpose
of the latter being to regulate the
flow of blood into the testis vessels
(a sufficiency only being allowed to
nourish them) and to better sustain
in position the suspensory.
However, the clamp may be dis-
pensed with, other lesions being absent
besides varicocele.
A sponging of cold water was then
applied to the imprisoned organ»
which not only relieved greatly the
painful bearing-down sensation, but as
well prevented undue irritation of the
parts through interference of adjust-
ments.
A wrap of a soft linen napkin
(wrung out of cold water) around
the penis and testicles at night upon
retiring, and left till morning, will be
found not only cool and relieving of
any and all inflammatory conditions,
but as well assist in shrinkage of the
testicle vessels, so necessary in re-
formation. Keep all instruments
washed and clean.
The milking method and sponging
in cold ablutions were indulged daily
for three or four days, the adjust-
ments being detached for that pur-
pose, lighter pressure being applied in
each application.
A cessation of disturbance then fol-
lowed, and the labor of restoration
was left entirely to nature; but the
reversement and attachment of the
testis to the belt was fully observed
and continued until reorganization was
fully accomplished, which required
but a few days.
This is absolutely requisite for suc-
cess, otherwise a failure will surely
follow or the adjustment must be worn
for a longer period.
Upon discarding the single suspen-
sory a regular suspensory, somewhat
smaller than the diameter of the
scrotum, was substituted, in order
to strengthen the reorganization of the
testis and prevent its return to its
defection, and also to disallow an
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m
WWch yields thirty limes iU vol-
lime of •• nascent oxygen " near
to tlie condition of •*ozone»'*
is daily proving: to physicians, in
some new way, its wonderful efficary
in stubborn cases of Bczema^ Paoriaaia, Sal^ RJEttfum, Iteh.
Barbaras Itob, Bryaipelaa, Ivy Roiaoning, Riagworm,
Herpea Zoater or Zotta^ etc Acne, Pimplea on Faoe
are cleared up and the pores healed by HYOROZONE and 6LYC0Z0NC
in a way that is
magical. Try this
treatment ; results
will please you.
Pall method of treat,
ment In my book.
•♦ The Thenpeuticml
Applications of Hy-
drocone and Glyco-
aone * ' ; Serenteenth
Edition, 339 pagvs.
Sent free to physlc^ns
00 tequesc.
Prepared only by
danist and r.radnate of the ** Ecole Ccntrale det
Arts et Manu&ctures de Paris " (France)
07-50 Prince Street, New York
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180
Original Articles.
undue scrotal elongation, so habitu-
ally inclined by a like condition of the
vessels of the testis ; hence the substi-
tution must be observed.
Upon adoption of the regular sus-
pensory the administration of the
Poison extracts was found most excel-
lent and beneficial to the genito-
urinary organs and the entire system
as well.
Suffice it to say that in a very short
time indeed nature kindly restored the
testis to its former condition, and
furnished an organ as solid as any
man coxxld possibly desire.
But right here allow me to warn ad-
visedly to the effect that in the treat-
ment throughout of these organs
great care and gentleness must be ob-
served at the preliminary, especially
so in the milking method and tying
process, or nature will ^^cry out and
kickj)ack,^^ To discourage an inflam-
matory condition becomes the first
requisite, ever remembering that these
organs are the most sensitory of the
entire human anatomy.
In a correspondence with a majority
of specialists of large experience in
treating genito-urinary disease, it was
learned that compression of the scro-
tum and testis and electrical appli-
ances were indulged ; also* astringent
lotions and ointments applied ; but no
reversion and elevation of the organs
were resorted to, nor milking method
followed, hence the failure.
Now let us return to the duty of the
physician.
The family medico is held in as
much reverence as the family minis-
ter; in fact, more so, because the very
life of its members depend wholly
upon him, in a sanitary point of view;
hence when that physician observes
any facial indication of **genital-
urinary abuse^' upon the part of their
sons, it becomes his most sacred duty
not only to so inform the parents
(particularly the mother), and advise
medical treatment at once, knowing
well, as he does, the total ignorance
of the parents of the abuse; and, as-
well, warn those sons of the serious-
consequences as a result.
With this most damnable deteriora-
tion of the human race, can we wonder
that infantile mortality assumes such
alarming proportions?
To say the least, the reformation of
this most serious malady lies within
the physician's power. Will he do itf
The adoption of this criminal prac-
tice upon the part of the younger ele-
ment is not so much due to voluntary
option, but is, as a general rule, ini-
tiated through the teachings of older
confederates, many being gi'own to
maturity — a fact indisputable.
Happy the day for the restoration
of the mass of the male sex of the
human family if a two-thirds number
of medicos now in general practice
would throw off the yoke of prejudice
and pursue a special course in genital-
urinary lesions.
svblaminb in the treatment of
syphilis.
By M. Fkiedlandbb, Berlin, Germany.
Though the general results of the
mercurial treatment in syphilis are
satisfactory enough, the forms in
which -the drug could hitherto be in-
troduced into the syst^ii left much to
be desired. The inunction of the oint-
ment is unscientific ; we have no means
of telling how much of the drug is
absorbed and how much is taken up
by the underclothing. Indeed, it is
now a matter of debate whether the
effects of this method are not ascrib-
able to the inhalation of volatilized
mercury during the process. There is
almost the same uncertainty when the
mercury is administered internally or
by baths.
Subcutaneous or intramuscular in-
jection is the only scientifically unim-
peachable method of administration,
but, unfortunately, all mercurial prep-
arations hitherto employed in this way-
have serious drawbacks. Corrosive
sublimate energetically coagulates the
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A WISE PRECAUTION
ON THE PART OF THE
FRESCRIBINa PHYSICIAN
When writing a prescription for
Eux. Salicylic Comp.
Would be to carefully specify
Warner & Co.
The original and wonderfully effective remedy, indicated in
RHEUMATISM
and analogous disorders.
The imitations and substitutes are the cause of failures and
injure the reputation of the prescriber and the genuine product.
There is no failure when the ''Warner" product is used.
Literature on request.
WM. R. WARNER & CO. Philadelphia
BRANCHES: NEW YORK, CHICAGO, NEW ORLEANS, LONOON.
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182
Therapeutic Suggestions.
tissue albumin, causing hard infiltra-
tion and severe pain. The other sol-
uble mercurial salts either contain too
small an amount of the metal or are
not sufficiently soluble. The insoluble
salts have the advantage of requiring
less frequent administration, but they
cause severe pain, and it is not pos-
sible to remove any portion of the
drug should the patient unexpectedly
show signs of mercurial intoxication.
The occasional deaths due to their
employment hardly incite to their
more general use.
Sublamine, mercurys ulphate ethyl-
enediamine, however, I found to be
extremely soluble and not to coagu-
late albuminous solutions. The suc-
cess of laboratory experiments made
in this direction induced me to try it
clinically.
Fifteen syphilitica were treated with
3.4 per cent, sublamine solutions, some
'280 injections being given altogether.
Some of the patients had fresh chan-
cres; others had papular, tubercular
and ulcerative * secondary syphilo-
derms, and the rest had syphilitic af-
fections of the mouth, tongue and
larynx. The action of sublamine was
exactly the same as that of sublimate.
Primary indurations softened and
healed, papular and tubercular syph-
ilides retrogressed, and the mucous
patches and ulcers of the mouth dis-
appeared.
But the reaction at the site of in-
jection was in every case far less
marked. All the injections were made
into the gluteal muscles. Indurations
did indeed occur, but they were smaller
and softer than those caused by sub-
limate, and disappeared more quickly*
It was also evident that the pain was
very much less. To eliminate the pos-
sibility of bias on the part of the ex-
perimenter, two patients were given
(without their knowledge) sublimate
injections in the midst of their subla-
mine treatment, and they both com-
plained at the next consultation of the
especial pain of their last injection.
Unpleasant by-effects were never ob-
served.
We therefore possess in sublamine
an anti-syphilitic that is readily sol-
uble, does not destroy the injection-
needle so rapidly, and, while as suf-
ficient as sublimate, causes less indu-
ration and pain.
THERAPEUTIC SUGGESTIONS.
In the treatment of catarrhal pyeli-
tis and the almost inevitably conse-
quent cystitis, Lithiated Hydrangea
(Lambert) in teaspoonful doses gives
the most satisfactory results.
_— —- -^ \
In dropsical conditions the first in-
dication is for the removal of the fluid ;
the second, removal of the cause. It
is not always easy to fulfill either of
these indications. Anasarcin possesses
the therapeutic properties to fulfill
both in a greater degree than any other
combination of drugs. It stimulates
absorption of the effused fluid, equalizes
the circulation and restores the phys-
iological action of the organs.
Obstinate cases of urticaria, lichen
and psoriasis associated with the uric
acid diatheses respond promptly to
teaspoonful doses of Uriseptin four
times a day.
Its good effect in these cases is due
to its action as a solvent of uric acid,
as a diuretic, gentle diaphoretic and
metabolic stimulant.
TiiYRADEN AND Thyroidin . — Thyra-
den is a lactose trituration of the dried
extract of thyroid gland, 1 part of
which represents 2 parts of the fresh
gland. The preparation has an agree-
able odor and taste, is reported to be
non-poisonous, free from ptomaines, of
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DO NOT FORGET
the importance of a remedy
that pacifies the irritable stomach
and intestines. This attribute of
GRAY'S—TONIC
COMP.
makes It the most valuable
Summer Tonic and reconstructive
in malnutrition, nervous exhaustion
and general debility.
THE PURDUE FREDERICK CO.
No. IS Murray Street, New York
k ,
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X84
Therapeutic Suggestions.
uniform action, without untoward by-
effects ih proper doses, and to repre-
sent active constituents of the thyroid
in the least changed, yet permanent
form. 1 gm. of thyraden represents
0.7 milligram of iodine. Thyraden
has been employed with good results
in myxedema, cachexy, cretinism, thy-
reopriva, struma, rachitis, adiposity,
psoriasis, lupus, leprosy, diabetes, etc.
The dose for adults is 2 to 4 grn. three
times a day, gradually increased in ex-
ceptional cases up to 8 grn., best taken
in tablets ; children receive one-quarter
to one-half of these quantities. Ex-
cessive doses produce weakness of the
limbs, heaviness of the head, palpita-
. tion and insomnia.
Thyroidin is the simple dried thyroid
gland of sheep, 1 part of which repre-
sents 6 parts of fresh gland ; it is thus
three times as powerful as thyraden,
and is accordingly given in one-third
the doses of the latter. Its indica-
tions and uses are identical with those
of thyraden.
Pain and Its Eemedy. — (By J. D.
Albright, M. D., Philadelphia, Pa.)—
. . . Believing that the bar in the way
of the profession, in the use of opium,
is its tendency to evil after-effects, and
the harum-scarum idea that a little opi-
um will induce the habit, and these
terrible concomitants (?) I wish to call
their attention to a preparation that I
have long been using, and have not yet
seen one case in which the habit was
formed, nor ever had any complaint as
to evil after-effects. This remedy is
papine, a preparation of opium from
which the narcotic and convulsive ele-
ments have been removed, rendering it
a safe remedy for children, as well as
for those of mature age. . . Up to a
year ago I always gave chlorodyne tab-
lets and viburnum for after-pains.
Then I came across a case that refused
to yield to them in the time I was ac-
customed to have them do so, and I
concluded to try papine. Its results,
to make the story short, were such
that I now never giveanytlung else for
after-pains, and they yield in aboi^t
half the time that was required with
the above named remedies. — Medical
Summary.
Weak tissues are a prey to infective
micro-organisms. By proper nutrition
the system is enabled to defend itself
against disease. In incipient tubercu-
losis three things are necessary : Out-
of-door life, nutritious diet and Hagee's
cordial of cod-liver oil comp. The
latter alone is tonic, nutritive, recon-
structive, pleasant to take and readily
assimilated by the weakest stomach.
Colorado Springs, Col., )
July 13, 1900. 5
MoR. Merz Capsule Co.:
Dear Sir: — I am glad to say that
the santal compound furnished me by
request from your house has proved
itself excellent in two severe cases of
gonorrhoea and one of cystitis. I don't
know of any other preparation so near
being a specific in prostatic troubles-
as the Merz santal co«
Yours truly. Dr. C. B. C.
Disease and dirt are the demoniac
twins of ignorance. Cleanliness is in-
deed godliness. Mucous membranes
inflamed and throwing forth unclean
discharges should be flushed with pure
warm water containing an alkaline,
soothing, healing germicide. We have
such in Tyree's antiseptic powder, and
this can safely be commended to the
public by physicians. Catarrhal dis-
turbances, no matter whether located
in the throat, nose, genito-urinary
equipment or rectum, can be promptly
relieved by using the Tyree's anti-
septic powder as directed on the box.
Neurilla in Epilepsy. — A case of
a boy twelve years old, nervous tem-
perament, who appeared inclined ta
epileptic attacks. I employed neurilla.
There was a great improvement from
the use of this valuable prescription^
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%%'%/%^%%%%1
il AN AS ARC IN
(Oxydendron-Sambucus-Scilla Compound.)
ii A SPECIFIC FOR DROPSIES
Doctor:—
If you know a thing to be a fact, it is not wrong or
unethical to say so. Neither does it smack of quackery or
Charlatanism and should not shock the sensibilities of any,
however refined, cultured or zealous of medical ethics for us
to claim that ANASARCIN is a specific in dropsies, when
clinical experience has demonstrated such to be a fact. If
quinine is a specific in malaria, much more is ANASARCIN
in dropsies resulting from disease of the heart, liver or
kidneys, because that a trial of it in hundreds, yea, thousands
of cases has not resulted in a failure known to us where
directions have been followed.
Besides being a specific for dropsies, it is a permanent
cure in the conditions mentioned when begun early and
continued a sufficient length of time, i, e,^ until the diseased
organs regain normal function. ANASARCIN is composed of
the active principles of Oxydendron Arboreum, Sambucns and
Urginea Scilla, and is sold exclusively to physicians or
druggists for physicians. Trial box free with literature and
testimonials furnished physicians on application.
A D DRESS
The Anasarcin Chemical Company
WINCHESTER, TENN.. U. S. A.
LONDON AQBNTS-
Tbos. Christy A Co., 4*10 '12 Old Swan Lane, Upper Thames St, B. C.
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186
New Publications.
and X ani now using same in my prac-
tice regularly.
William Richardson, M. D.
North Londonderry, N. H.
Pneumonia is prevalent throughout
the United States, especially during
the summer months. It attacks old
and young alike, and occurs more fre-
quently in cities than in the country.
Confine patients in a dry, sunny, well-
qtired room, temperature 70°; food
should be liquid, viz., milk, broth
and meat juices, and given at stated
intervals in small quantities. When
nervous symptoms first appear begin
the use of Daniel's cone. tr. passiflora
incarnata, in small doses. It is safer
and more effective than morphine or
the bromides.
Colorado in Summer. — Colorado ia
summer is the most delightful place in
the country. The health and pleasure
resorts of this wonderful state are best
reached by the Colorado & Soutlverp
Railway, which issues an elegant book
"Picturesque Colorado," a copy of
which may be had by enclosing three
cents in postage to T. E. Fisher, G. P*
A., Denver Colo.
NEW PUBLICATION'S.
A 8T8TEM OF Phtsioloqic Thibapeutics. By Solo-
mon SoLis Cohen, A. M., M. D., Senior AsslstaQt
Professor of ClinicAl Medidne in Jefferson Medical
College. Volume V. Prophylaxis, Personal Hygiene,
Civic Hygiene, Care of the Sick. By Joseph McFar-
land, M.D.; HenryLeffman, M. D.; Albert Ahrams,
A. M., M. D., and W. Wavne Babcock, M. D. Illus-
trated. Published by P. Blakiston's Son & Co., 1012
Walnut street, Philadelphia, Pa. 1903.
This important volume of the above
System of Physiologic Therapeutics is
a valuable contribution to medical
science. The necessity of a more ex-
haustive study of prophylaxis and hy-
giene, and a more general application
of these auxiliary forces in the subju-
gation of disease, is recognized by
every progressive physician. The mere
recognition of disease and familiarity
with the therapeutic properties of
drugs in its treatment are inadequate
equipments for a successful practi-
tioner of medicine. He should be
thoroughly acquainted with the intrin-
sic and extrinsic causes of disease as
well as all its channels of transmission.
He should be prepared to defend the
human organism against its first ap-
proaches. The prevention of disease
is paramount. It simplifies the work
of the physician and saves him many a
hard battle. This book in a bi^oad-
gauged spirit outlines the course he
should pursue. Part 1st discusses the
origin and prevention of disease* Part
2d takes up civic hygiene. Part 3d
treats of domestic and personal hy-
giene, nursing and care of the sick
room.
INDEX.
Original Abticucs. • page.
Median Perineal Urethrotomy and Cystotomy
Through a Superficial Transverse Incision, After
Celsus. By Walter G. Spencer, F. R. C. S., M. S.,
M.B 14:1
Pemphigus Vegetans. By L. P. Hamburger, M. D.148
Spermatorrhoea as a Disease Sui Generis. By J. A.
I)eArmond, M. D 164
Prostitution in Japan. By Albert S. Ashmead,
M.D 167
Original Articles. page.
Prostatic Surgery— Historical and Experimental.
By Benjamin Merrill Ricketts, Ph. B.. M. D 168^
Syphilis of the Nervous System. By Frank E.
Coulter, M. D 170-
A Simple Remedy for the Cure of Varicocele. By
Frank A. Brewer, Sr., M. D... 17ft
Sublamine in the Treatment of Syphilis. By M.
Friedlander ISO
Therapeutic Suggestions 182
New Publications 18ft
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J
A •l-MONTHLV MAQAZINK DCVOTKD TO THK OONSIDKflATION OF CUTANEOUS MKDICINK
VKMKIIffAL MSffASffS AND OCNITO-URINAIIY •UftOKIIY.
S. C. MARTIN, M. 0.
I or OtWM A I OM it r in THC OMINtt MtOMM. <
EDITORS
6. M. PHILLIPS. M. 0.
•w or oiNrroHifiiMAiiv oraiMto or. louio oo t t— r or
MANAGING EDITOR
S. C. MARTIN. Jr.. M. 0.
SUBSCRIPTIOMS AND ADVERTISING.
advance, postage prepaid, for the United Statet, Canada
' the postal union. Single copies, 2S cents.
^ . , matter regarding advertising, and make all checks, drafts
and post-office orders pa3rable to
AMERICAN JOURNAL OF DERMATOLOGY.
Fidelity Boildingr. St. Louis, Mo., U. S. A.
Vol. VII.
SEPTEMBER, 1903.
No. 6.
DBRMATOLOQiCAL TBACMNQ IN
MADRID.
Bt a. Rato«li, M. D., Olneinaati, Ohio.
The International Congress of Med-
icine in Madrid has showti to the med-
ical world some interesting work on
dermatology, with which we English-
speaking people were not well ac-
qaainted. It has, furthermore, brought
us together with colleagues of the
greatest learning, who are constantly
working for the advance of our sci-
ence.
The city of Madrid has a large hos-
pital called St. John de Dios, which is
solely for diseases of the skin. It is
situated somewhat on the outskirts of
the city on a magnificent spot, with
open air and plenty of light. It is the
pavilion system, and is built in the
middle of magnificent gardens. I
must thank Dr. Juan Azua, professor of
dermatology and syphilology of the
Facultad de Medicina of Madrid, who
took Dr. von Duering and myself
through his wards for a special visit
to the hospital. The wards are not
very large ; they contain an average of
from twenty to twenty-four cots, and
are clean and well kept. The Sisters
of Charity take care of the patients, as
they lack an institution for training
nurses. The hospital is built in pa-
vilions, making twenty-five in number,
surrounded by elegant gardens.
In every ward were interesting
cases, but the purpose of Dr. Azua
was to call our attention to a case of
multiple cutaneous necrobiosis, re-
sulting from capillary stasis, which
had been the subject of his communi-
cation to the congress.
His patient was a man twenty-seven
years of age, the whole surface of
whose skin was of a bluish brown
color, giving it a marbled ap-
pearance, and which was uniformly
extended from the elbows to the
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188
Original Articles.
hands and from the knees to the feet,
giving an intense cyanotic discolora-
tion. The veins of both extremities
were greatly turgid and distended.
The ears and lips of the patient were
also bluish and somewhat cyanotic.
The interesting point was that when
the patient was lying down in a hori-
zontal position his feet and arms re-
turned / to a normal color, being
relieved from the higher pressure of
the blood. Azua called attentiop to
the condition of inertness of the veins,
which loob;ed like tubes, without any
resistance.
In the. parts of the skin mostly sub-
ject to pressure the patient showed a
great number of necrotic spots. The
necrosis begins ordinarily on the
places where the capillary stasis is
most marked, in the form of a brown-
ish spot, without any subjective dis-
turbance, only marked by diminished
sensibility. The color becomes black
and the necrotic skin gets dry, and
the surrounding skin, cyanotic and blu-
ish from the venous stasis, becomes
swollen and edematous. The necrotic
skin in a period of time, varying from
three to four months, is detached in
the form of dry eschara, surrounded
by thick, dry scales, leaving a cicatrix
the size of the eschara. On the legs,
however, the stasis being more intense
and the caudation more abundant, it
causes the gangrenous spot to be of
the humid type, and sloughs off sooner,
leaving an open sore.
Between the superficial necrotic
points others are formed of a much
deeper and severer nature. In this
case the gangrenous process affects
the skin and the subcutaneous tissues.
The spot is dark brown, hard to the
touch, the epidermis is detached by
blisters containing brownish serum,
and soon the whole place is changed
into a deep ulcer.
The resulting ulcerations after the
sloughing of the necrotic tissues are
of a healthy, red color, the granula-
tions are readily formed and heal up,
leaving a superficial scar.
Azua called our attention to the
normal temperature of the patient,
which is between 36.2° and 37° C,
showing a diminution of nearly one
degree. Hands and feet are con-
stantly cold, and the palms and soles,
are always moist with abundant per-
spiration.
The mucous membranes were per-
fectly normal.
The examination of the blood showed
it to be at the normal standard, and
the urine was in perfect condition.
The pulse of the patient was some-
what weak and rapid; when lying
down in bed it reached from 78 to 90,
and after a little exercise went to 120
and 130. The heart seemed somewhat
dilated in the left auricle. The con-
dition of the stasis of the skin is
claimed to have been of congenital or-
igin, and there has been no acquired
specific infection in the patient.
Azua explained the symptoms of
palpitation and some dyspnea as the
result of difficult capillary circulation
rather than the effect of a central cir-
culatory trouble.
His conclusion was that the disease
consists in ^^ primary muitiple necrobi-
QsiSy from capillary stasis.^ ^ The dis-
ease is congenital and its cause seems
to be an embryogenic malformation of
the tissues forming the walls of the
blood vessels, especially of the capil-
laries*
The accurate description of the dis-
ease illustrated with numerous plates,
the exact study of all its symptoms,
of its etiological factors, etc., made
such an impression on the members of
the congress that they decided to call
this disease by the name of disease
Azua.
One of the pavilions of the hospital
is occupied by the dermatological mu-
seum. The institution has been in ex-
istence for nearly thirty years and is
in connection with the dermatological
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Dermatological Teaching— Ravogli.
189
laboratory. It was beffun by the ef-
forts of the distinguished dermatolo*
gists, Jose Eagenio Olavide, Eus^bio
Castelo y Serra, professors in the
same hospital.
Both enriched the museum with a
large number of moulages, represent-
ing exactly the most important cases
during their service. Thi^s work was
enlarged with the collection of Drs.
Perez Gallego, Pedro Martinez,
Mossas San Juan and Manuel Ramos,
who had been professors in the same
hospital.
At present the pathological labora-
tory and the museum department is in
the hands of the professors of the hos-
pital, Manuel Sans Bombin, Francisco
Cerezo, Fernando Castelo, Matias
Martin Romero and Juan Azua.
The hospital is under the direction
and supervision of the Diputacion
Provincial^ together with the general
hospital. They are now building a
new pavilion for the museum, leaving
it independent of the laboratory.
Every pathological piece in the mu-
seum is accompanied by its clinical
history, and the doctors of the hos-
pital give a course of lectures to the
students, taking advantage of so mag-
nificent a collection.
The rooms of the museum have large
shelves, of which thirty-three are oc-
cupied by dermatological models.
There is an interesting collection of
models representing chancroids of the
different regions with resulting .bubos.
Vegetations in the different forms of
mucous membranes of the genitals. A
complete collection of models repre-
sent the syphilitic initial lesion in all
its varieties in the genitals, and another
represents cases of extragenital chan-
cres ; among them is worthy of note a
hard chancre of the tragus of the
auricula.
A very good collection of models
represents the mucous patches in all
their varieties, and, in the same way,
the different eruptions of the second-
ary and tertiary period of syphilis.
Case No. 15 is occupied by models
representing leprosy in all its periods
and varieties, beginning with cases
showing simple discoloration, lepra
alba, to all its varieties of lepra tuber-
osa and ulcerosa.
Case No. 16 contains a large collec-
tion of cases of lupus and other scrof-
ulous eruptions, mostly from the
service of Azua and Olavide. This
collection is continued with many mod-
els of rhinoscleroma and of tubercu-
losis verrucosa and of ulcerated jscrof-
ulodermata.
There also deserves mention a collec-
tion of magnificent models represent-
ing eczema in all its varieties and
stages, and also a collection of cases of
ichthyosis..
Very interesting and faithful repro-
ductions of erythema caused by pella-
gra attracted my attention, as' they
showed the different stages of this
disease. One entire case is filled with
models representing forming of tri-
cophities and cases of favus of the
scalp and of the body. Neoplasmata
of benign and of malignant nature
have interesting specimens.
Medical students and physicians are
allowed to enter and study in the mu-
seum at certain hours. The work of
the moulages is done by the artist,
Henry Zofio, who teaches others the
way to prepare the composition and
give the colors to the models.
The expenses are all charged to the
Diputacion Provincial^ which encour-
ages the officers of the hospital in this
interesting and useful work.
I must say, not without regret, that
the teaching of dermatology in Madrid
is farther advanced, has better oppor-
tunities and receives much more en-
couragement than among us.
W
In alopecia seborrhoica, where there
are signs of con(imencing inflammation
of the scalp, a lotion of glycerini plumbi
subacetat ji, liq. carb. detergens,
gss, aqua rosse ad, Jviii, is often one
of the best applications.
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Original Articles.
HVOROCBLB^ITS CURB BY A SIMPLB
OPBRATION.
Bt B. F. liicoBiSH, M. D., Barbados. West Indies.
The following metbod of operative
treatment for hydrocele is so easy of
performance, so simple in explanation
and so trifling as regards its immedi-
ate aftei'-effects when done aseptically,
entaihng no confinement to bed, that
I place it before the profession, confi-
dent that the above points in its favor
will render it worthy of general recog-
nation and adoption.
It is thus done : Pass a very narrow-
bladed knife through both outer and
inner sacs of the hydrocele and slit the
inner one — tunica vaginales - for about
half inch, withdraw the knife, and if
the hydrocele is a large one, allow about
half of the fluid to pass out; if the
hydrocele is small, allow none; then
close the outer wound. The result is
that the remaining fluid gradually finds
itself in the loose connective tissue be-
tween the sacs, and is gradually ab-
sorbed. A cure is thus effected. The
fluid passing slowly over the edges of
the inner wound prevents its closure ;
hence, a permanent passage from the
inner sac to the loose connective tissue
is left by which all subsequent secre-
tion is removed. This is also the ex-
planation of cure where a portion of
the sac is excised. As this latter is,
however, a far more formidable opera-
tion, the points in favor of mine, as
given above, must turn the scale
strongly in its favor. This modus
operandi of cure also explains that of
iridectomy for glaucoma ; and just as
my operation is to be preferred to ex-
cision of the sac in hydrocele, so, I
believe, a simple incision at the angle
of the anterior chamber, enlarged in-
ternally, will take the place of iridec-
tomy ; for as both diseases are sequels
of inflammation — Prof. Bossa's recent
experiments going to prove this as
regards glaucoma — we must see that
a like result will follow similar opera-
tions. Glaucoma then is simply hydro-
cele of the eye. The idea is to secure
a permanent exit for the accumulated
fluid and for subsequent secretions,
so that there may be a gradual absorp-
tion of the effusion, the sequence of
the inflammation.
PRQSmVTIOS IN JAPAN.
BT SoLOicoN CulibOSmk MABtiN, Jb., H. D., St. Louis.
CHAPTER I.
In order to better understand the
peculiar features of Japanese prosti-
tution, it is necessary to get a glimpse
of the social, religious and gov^n-
mental influences which have been such
potent faotors in molding Japanese
character. All of the vices of a na-
tion bear more or less the impress of
national custom, or the label of popu-
lar fashion. If a certain people are
noted for cleanliness and gentle be-
havior, their worst vices will more or
less partake of these characteristics.
Society in Japan differs widely from
that of all western nations. The peo-
ple are not divided into a large variety
of classes on the lines of culture,
wealth, lineage, commercial status or
religion, as in Europe and America^
There is no aristocracy outside of ofli-
cial circles, and even this somewhat
exclusive class, apart from the high
officials of the government, does not re-
ceive any special recognition from the
common people.
The Japanese are essentially demo-
cratic in all their affiliations, with the
single exception of their implicit and
loyal submission to their government
however arbitrary it may be. To-
wards foreigners they are courteous,
frank and obli|ring in their behavior,
but never confidential in matters that
pertain to their private affairs.
Males treat females with a certain
degree of consideration and kindness,
but never regard them as equals. The
women, accustomed to being regarded
as inferiors, are rarely self-asserting or
willful, and are not inclined to take
the initiative in anything outside of
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Prostitution in Japan—Martin.
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their domestic duties. They do not
receive any special homage from the
men, and while they seem to be satisfied
with their condition^ it is not natural
that they should be inclined to hero*
worship ; besides, the women are bet-
ter looking than the men, and this
may also . have something to do with
their apparent lack of enthusiasm for
the opposite sex.
, The marriage relation is also not
calculated to make life what it should
be for the women. Marriage in Japan
is not a matter which exclusively con-
cerns the parties to the cgntract. It
is usually arranged by the two families,
regardless of the wishes of eith^
party most deeply concerned. This
is especiaUy true with regard to the
girl, who is regarded as a non-entity.
While marriage is a legal contract in
Japan, as long as the man and woman
live under it, according to Japanese
law, it can be annulled at any time by
the will of the married couple. Under
the existing laws marriage in Japan
cannot be considered a sacred or stable
institution, and consequently one of
the great barriers to immorality is
greatly weakened. The Japanese are
not any more immoral than other more
cultured nations, and perhaps not so
much so as some of them. This is
very much to their credit, as their
religion, if they have any (which
is doubtful, according to European
ideals), their laws and social usages
are not calculated to put a premium
on virtue. They are naturally a clean,
temperate and orderly people, and we
can readily understand as a race they
would not tolerate any departure from
these characteristics in the sexual rela-
tions of any class of their people.
Whilst the Japanese cannot be called
a religious or devotional people, they
are not irreligious. They are so free
from bigotry that they tolerate in
their peculiar belief an admixture of
Shintoism, Buddhism, Confucianism
and Christianity, Shinto, in a certain
sense, is their national religion, but
this does not teach or enforce any
system of morals; it i? simply a blend-
iqg of mythology, nature and ancestor-
worship. It has no moral code, and
reveals nothing of a future life. Ac-
cording to this doctrine, there is no
heaven or hell, but occasional mtima-
tiuns of a dim, misty hades. Bud-
dhism is a kind of religious ceremonial
with altars, candles, incense, rosaries,
images and processions, with gods and
goddesses, but no supreme God or Crea-
tor of the Universe. It stands for
knowledge and seff-perfectionmept aa
the means of transference into Nirv-
ana, which is supposed to be a state of
S4q)reme beatitude or annihilation.
Confucianism is a system of philoso-
phy which teaches ethics, morals and
unconditional submission to govern-
ment. There certainly is nothing in
this doctrine repugnant to the adminis-
trators of the law, and, therefore, it
enjoys the official recognition of the
Mikado and his court.
In addition to the above doctrines
which have been so harmoniously ac-
cepted and blended in Japan, the
modern spirit of progressiveness has
adopted some of the more assimilable
features of Christianity. It is, how-
ever, a curious fact that while Japan
has, by the absorption of modern
ideas, in the last thirty years, trans-
formed itself from an isolated, insig-
nificant nation, into a world-power, it
still clings to many of the absurd
traditions of prehistoric times.
CHAPTER II.
YOSHIWARA.
Up to 1596 prostitution in Yedo
(now Tokyo) was an unlicensed and
unregulated institution. It had no
fixed place of abode, and as a result as-
signation houses and brothels were
distributed in groups or singly to suit
the convenience of inmates and pa-
trons. There were, however, three
quarters in close proximity to eaeh
other, where about fifty of these
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Original Articles,
houses were established — Eoji-macbi,
Eamakura-gashi and Yangi-machi. At
this time Yedo was a small, insignifi-
cant place, but having been selected
for the seat of the Takugawa govern-
ment, it was rapidly increased in popu-
lation by the influx of adventurers,
speculators and parasites of the gov-
ernment from every part of the coun-
try. Among the immense hordes of
newcomers, as might be expected,
were many of that disreputable class
who either enter the ranks of prosti-
tution or hover around its outskirts
for the purpose of appropriating the
proceeds of the infamous trade.
The brothel house business was not
in a languishing state while other lines
of trade flourished. The number of
disreputable dens rapidlj^ increased
until, with the growth of legitimate
business, there was little room left for
the shameful industry, and the gov-
ernment began to adopt restrictive
measures which finally culminated in
the segregation of this class and their
subjection to the dominion of law and
order.
The construction of the Castle of
Yedo, and the extension of municipal
improvements, soon encroached upon
the territory occupied by houses of
ill-fame and their removal to other lo-
calities followed. The brothel-keep-
ers, in their trouble, requested the
government to allow them to establish
a courtesan quarter. Their petition
did not receive any attention until
in 1612 a persevering reformer by the
name of Shoji Jinyemon, who was an
interested member of the "profes-
sion," made such a powerful plea to
the government for the assignment of
prostitution to a special quarter of the
city, that after five years' deliberation
the petition, with certain qualifica-
tions, was granted. His plea to the
government was couched in the follow-
ing language:
In Kyota and in Suruga, and also in all
other thickly populated and busy places (to
the number of more than twenty) there have
been established, in accordance with ancient
custom and precedent, regular licensed K^eisei-
machi, whereas, in Yedo, which is growing
busier and more popnlous day by day, there is
no fixed Yujo-machi. In consequence of this
state of affairs housea of ill-fame abound in
every part of the city, being scattered hither
and thither in all directions. This, for nu-
merous reasons, is detrimental to public mo-
rality and ^welfare, etc., etc.
(1) As matters stand at present, when a
person visits a brothel he may hire and dis-
port himself with Yujo (filles de joie) to his
heart's content, give himself up to pleasure
and licentiousness to the extent of being un-
able to discriminate as to his position and
means and the neglect of his occupation or
business. He may frequent a brothel for days
on end, giving himself up to lust and revel, but
so long as his money holds but the keeper of
the house will continue to entertain him as a
guest. As a natural consequence, this leads
to the neglect of duty towards masters, defal-
cations, theft, etc., and even then the keepers
of the brothels will allow the guilty ^ests to
remain in their<houses as long as their money
lasts. If brothels were all collected into one
place a check would be put to these evils, as,
by means of investigation and inquiry, a
longer stay than twenty-four hours could be
prohibited and such prohibition enforced.
(2) Although it is forbidden by law to kid-
nap children, yet, even in this city, the prac-
tice of kidnapping female children and entic-
ing girls away from their homes under false pre-
tenses is being resorted to by certain vicious and
unprincipled rascals. It is a positive fact that
some evil-minded persons niake it a regular
profession to take in the daughters of poor
people under the pretext of adopting them aa
their own children, but when the girls grow up
they are sent out to service as concubines or
prostitutes, and it is in this manner the indi-
viduals who have adopted them reap a golden
harvest. Perhaps it is this class of abandoned
rascals that even dare to kidnap other peo-
ple's children. It is said to be a fact that there
are brothel-keepers who engage women, know-
ing perfectly well that they are the adopted
chil<£ren of the parties who wish to sell the
girls into prostitution. If the prostitute
houses be all collected into one place, strict
enquiries will be made as to the matter of kid-
napping, and as to the engagement of adopted
children, and should any cases occur in which
such reprehensible acts are attempted, in-
formation will be immediately given to the
authorities.
(3) Although the condition of the country
is peaceful, yet it is not long since the subju-
gation of Mino province was accomplished,
and consequently it may be that there are
many ronin prowling about seeking for an op- >
portunity to work mischief. These ruffians
have, of course, no fixed place of abode and
simply drift hither and thither, so it is impos-
sible to ascertain their whereabouts in the ab-
sence of properly instituted enquiries even
although they may be staying in houses of ill-
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Prostitution in Japan— Martin.
108
fame for a considerable nnmber of days. If
the authorities p^rant this petition and permit
the concentration of the existing brothels in
one regular place, the brothel-keepers will
paj special attention to this matter and will
canse searching enquiries to be made about
persons who maj be found loafing in the pros-
titute quarters, should they discover any sus-
picious characters the^ will not fail to report
the same to the authorities forthwith.
It will be deemed a great favor if the ausust
authorities will grant this petition in the full-
ness of their magnanimous mercy.
Shogi Jinyemon^ who, it seems, was
not only a reformer, but ^ood politi-
cian, succeeded in having himself ap-
pointed director of the prostitute quar-
ter, under the pledge of enforcing the
following regulations :
(1) The profession of brothel-keeping shall
not be carried on in any place other than the
regular prostitute quarter, and in future no
request for the attendance of a courtesan at a
place outside the limits of the enclosure shall
be complied with.
(2) No guest shall remain in a brothel for
more than twenty-four hours.
(Z) Prostitutes are forbidden to wear clothes
wiui gold and silver embroidery on them; they
are to wear ordinary dyed stuffs.
(4) Brothels are not to be built of imposing
appearance, and the inhabitants of prostitute
Quarters shall discharge the same duties (as
remen, etc.) as ordinary residents in other
parts of Yedo city.
(0) Proper enquiries shall be instituted into
the person of any visitor to a brothel, no mat-
ter whether he be gentleman or commoner,
and in case any suspicious individual appears
information shall be given to the Bugyo-sho
(office of the city governor).
The above instructions are to be strictly ob-
served. (Date. ) Thb Bugyo.
The site at Fukiya-Machi selected
by the authorities for the founding of
quarters for prostitutes was a low,
level plot of ground embracing an area
of about twelve acres (two square
cho), which at this time was covered
with weeds and reeds. The name,
Yoshiwara, which literally means Plain
of Reeds, was therefore adopted as a
designation of the prostitute quarters,
and afterwards came into general use
in all the large cities of the empire as
an appropriate name for this abomina-
ble institution. The work of prepar-
ing the ground and building houses
commenced in 1617, and in less than a
year ''business" was in full blast,
although the quarters were not fully
finished before the year of lt526. Aftei:
all improvements had been completed
for the comfort and convenience of
this sporting community and the
''business" had gone on smoothly for
nearly forty years, the denizens re-
garded this place as their permanent
home; but in the year 1656 all of
their calculations were rudely upset
by an edict from the governor
(Bugyo), directing the removal of all
houses to another place, as this quar-
ter was needed to meet the demands
of more legitimate industries. Many
efforts were made by the elders of the
Yoshiwara to induce the governor to
rescind his order, but their petitions
were rejected, and they were com-
pelled to accept from the authorities
the grant of a plot of land in the
neighborhood of the Nihon-dsutsumi,
which was accompanied with the fol-
lowing liberal terms ;
(1) Hitherto the ground to be occupied has
been limited to two square cho; in the new
place these limits will be increased by 50 per
cent., and extended to three cho by two cho
(8x2).
(2) Whereas, hitherto, the profession has
been allowed to be carried on in the day-
time only, in consideration of the quarter tie-
ing moved to such a distant place it is, in
future, permitted both day and night alike.
(3) More than 200 Furo-ya (bath-houses),
now existing in the city, shall be abolished.
(4) In consideration of the Yoshiwara being
removed to a distant place, its people shall
hereafter be exempted from the duties of act-
ing as guards against fire on the occasion of
the festivals at Sannoand at Kanda, or as fircr
men in time of conflagration, etc.
(6 ) The sum of 10,500 ryo will be granted to
assist the expenses of removal, at the rate of
14 ryo per small room.
In accordance with the conditions
provided by the authorities for the
new Yoshiwara (Shin- Yoshiwara) it
will be seen the area of ground is in-
creased from two square cho (nearly
twelve acres) to three cho (nearly
eighteen acres), and the ^'business'* is
allowed to be carried on day and night,
instead of the day-time only, as was
formerly the rule. The bath-houses
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Original Articles.
(Furo-ya) were abolished, as they
seriously interfered with the regular
''business." Those bath-houses, like
nearly all others from time immemo-
rial, the world over, were merely se-
cret or unlicensed brothels, conductr
ing, under the guise of bathing, the
abominable trade of prostitution.
The munificent sum of 10,500 ryo
($5,250) was allowed to assist in d^
fraying the expenses of removal. The
managers of the Yoshiwara obtained
this sum with also the indulgence of
four months' time to effect the removal,
but the great fire, called the ''Furi-sode
Kwaji,*' on March 2, 1657, swept ov^r
the city of Yedo before the specified
time expired, destroying a large part
of the city, and almost entirely wiping
out of existence the Yoshiwara. This
great disaster hastened the work of re-
moval, and in a few weeks temporary
shanties were prepared for the use of
the prostitute class, on the site of the
New Yoshiwara, until sufficient time
was allowed for the erection of perma-
nent buildings. The ••trade" was not
seriously interrupted by the sudden
change of locality. On the other hand,
the circumstances attending the trans-
ition were such as, in a great measuie,
to cause a partial suspension of the
rigid rules governing prostitution,
which enabled brothel-keepers to mul-
tiply their methods of robbing their
patrons. The new Yoshiwara was
beautifully laid out in a quadrilateral
figure, or in the form of a parallelo-
gram, with four streets — one passing
through the center from the great
gateway (0-mon), called Naka-nocho,
and three, intersecting this at right
angles, called Kyo-machi, Sumi-cho
and Yedo-cho. The continuation of
Sumi-cho to the right, on account of its
large number of assignation houses
(Ageya), was called Ageya-machi, or
assignation house street. In 1668 the
class of Jigoku( unlicensed prostitutes)
became so numerous in the city of
Yedo, and were plying their vocation
so openly, that the authorities found
it necessary to gather them into the
Yoshiwara. As there was not room for
over five hundred newcomers in the
houses already built, and very little
room for additional buildings in the
Yoshiwara, additional ground in the
rear of the existing brothels was se-
cured and new quarters prepared for
their accommodation. In the course
of time the fashions of this • 'earthly
paradise" required changes in the name
and character of some of its establish-
ments. Ageya, or assignation houses,
were abolished, and Cha-ya (tea-
houses) took their places. The name
of assignation house became distaste-
ful to both inmates apd patrons, and
tea-house was substituted, because,
probably, it was less suggestive of the
real occupation of its inmates.
The Japanese are a fastidious and
orderly people, and this characteristic
is witnessed in the conduct of the pros-
titute class. There is a certain amount
of order and decency even among pros-
titutes in plying ^heir villainous trade.
While these unxortimate females may
really be divided into three classes, the
Jijoku, or unlicenseavclass ; the Shogi,
or licensed class, andvthe Geisha, or
professional singers aM dancers, for
the sake of an outwarcV. show of de-
decency, these classes aiV artistically
subdivided and **christeLVd" with a
great variety of eupbonious^nd ethical
titles expressive of the different forms
in which they exercise their calling.
As the members of these yifferent
classes break away from thv\ usages
which they are supposed to c^serve,
their names are changed, and tl^y are
re-classified, or relegated to the lowest
rounds of the ladder. ProstitutW at
best is an abominable evil, whicL can-
not be defended from any stand^loint,
but leaving out the moral aspect cf the
question and placing it on grounjia to
be viewed solely from an ethical, so-
cial and sanitary standpoint, Japan, in
dealing with it, in many respects, /is far
in advance of some of her morel pre-
tentious neighbors of western ci riliza-
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Prostitution in Japan—Martin.
106
tion. Prostitution in Japan has always
been under rigid police surveillance.
While the Japanese are the easiest
people in the world to govern, the au-
thorities do not neglect to devise stern
laws for their government, and they
are not lax in enforcing them. As a
sample of the government's vigilance,
I quote the following proclamation is-
sued by the governor of Tokyo in
1722:
Whereas secret prostitution has been pro-
hibited in the wards of this city, aiid whereas
it appears that the practice has been car-
ried on in an audacious manner, it is hereby
ordered that henceforth secret prostitutes shall
be treated as follows:
(1) The person harboring secret prostitutes
will be ordered to yield up to the government
his ground lot, furniture, house and godown,
and the woman offending shall herself have
her furniture seized, and for the space of 100
days shall be manacled with irons and com-
mitted into the custody of the responsible par-
ties of her ward, an officer being detailed oU
to visit the house every other day to inspect
the seal on her manacles.
^2) The owner of pounds and houses in
which secret prostitution takes place shall be
held in the same penalties, even although he
is not living on the premises, but only repre-
sented by a care-taker. The care-taker snail
have all his furniture seized, and shall be
manacled for a period of 100 days, during
which period he will be committed into the
custody of the responsible parties in his ward,
and every other day the bonds shall be exam-
ined and the seals inspected.
Three days after this date the appointed of-
ficials and Yoshiwara authorities will proceed
to search for persons carrying on illicit pros-
titution, and if those persons are apprehended
they will be dealt with as stnted above.
Persons harboring: offenders may be pun-
ished with banishment or death, and, more-
over, the members of the ward who are re-
sponsible for the parties may be likewise pun-
ished, in accordance with the foregoing. Now,
therefore, take notice, and let this be pub-
lished throughout the city.
Again, in 1876, the following order
was promulgated, dated the 27th of
January, and numbered 23, as fol-
lows:
Persons practicing secret prostitution and
the keepers of secret houses used for that pur-
pose, shall be punished as follows:
Principul or Accessory:
First offense — Fine not exceeding 10 yen or
two and one-half months' imprisonment.
Second offense — Fine not exceeding 20 yen
or five months' imprisonment.
Keeper of the house:
First offense — Fine not exceeding 15 yen or
three months' imprisonment.
Second offense— Fine not exceeding 80 yen
or six months' imprisonment.
CHAPTER III.
When ''business" in the Yoshiwara
begins to fall away the brothel-keepers
devise new methods of increasing their
revenue. They invent new procedures
and change the names of special call-
ings according to the requirements of
the situation. If they find that new *
customers are timid about entering the
various brothels, they appoint ushers
to conduct them to such houses as they
think will suit their tastes. To certain
houses the duty of introducing guests
is assigned. These establishments are
called "Introducing Tea-houses'* (Hi-
kiti-Jaya). The better class of these
houses is located within the enclosure
and is under the direct supervision of
th^ authorities, but many houses of
this character, less select and less ac-
curately disciplined, are situated out-
side the great Gate. There are in
each of the better class of "Introduc-
ing Tea-houses" (Hikiti-Jaya) within
the Yoshiwara, three or four attract-
ive girls, who arrange the introduction
of guests to the inmates, to the satis-
faction of their employers. One of
these girls will take charge of the
guest, ascertain his choice of brothel
and courtesan, and will then conduct
him to the desired place, arrange for
suitable favors, and will wait upon
him until the sake bottles have been
several times emptied and replenished.
When the refreshments are served and
disposed of, to the satisfaction of the
guest, the guide shows him his room,
waits until his female friend arrives
and then takes her departure. This
waiting maid sees that all the wants of
the guest are fully supplied until he is
ready to leave, when an itemized bill,
including her services, is presented
and settled by the guest, who is pain-
fully surprised to find that the bill al-
most exactly tallied with the contents
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of his pocket-book. The correct esti-
mate of the guest's finances may be
readily understood when it is known
that the authorities of the Yoshiwara
distribute registration books to the va-
rious tea-houses in which are recorded
the personal description and all visable
belongings of visitors.
At the same time all the brothels
keep a similar set of books for compar-
ison with those of the tea-houses. The
introducing houses assume the grave
responsibility also of accounting to the
authorities for the character and con-
duct of the guests whom they intro-
duce. Credit is not often extended to
the guests unless they are known to be
trustworthy and financially responsible
for their debts, and the introducing
houses must know this, for the guests
pay them for all accommodations and
they settle at stated times with the
brothels. Between the introducing-
houses, their servant maids and the
brothels, all business is conducted on
the basis of mutual confidence.
The Hikiti-Jaya, or introducing-
houses, derive their income principally
from commissions on fees paid to
courtesans, dancing girls, and percent-
ages on food and sake furnished to
the guest, as well as tips received from
visitors who are disposed to be lavish
with the use of their money. Besides,
these introducing-houses will have
nothing to do with visitors who do not
patronize first or second-class es-
tablishments. Such visitors gener-
ally fall into the hands of the emis-
saries of a low class of tea-
houses, either inside or outside of the
enclosure, who fleece them in a less
artistic style, but in an equally thor-
ough way. They very often fill them
up with sake, and when they settle
their bills their mental condition is
such that they readily pay for many
things they never got, as well as ex-
orbitant sums for what they did get.
This class of bunco-steerers know
how to size up their victims as well as
their more refined co-workers. There
is now and always was a fastidious
class of higher-ranked people who were
ashamed to be seen entering the Yoshi-
wara. Such people resort to various
disguises to hide their identity. It
was formerly the custom of certain
tea-houses outside of the great Gate,
called Amigasa-Jaya to furnish them
with a basket-shaped hat, made of
rush, which, when placed on the head,
concealed the face of the wearer.
These braided hats were supplied for
the small sum of 10 sen (5 cents),
part of which was returned when the
hat was brought back. This device,
however,has been abandoned and other
less conspicuous methods adopted.
With all of the different phases of
vice witnessed in the Yoshiwara there
is an outward appearance of decency
required by visitors, and cheerfully
complied with by the denizens of this
quarter.
Formerly there were very many
artists, male and female, known as
Geinin. These artists became too
familiar with the Geisha or dancing
girls, and their liasons with this class
became so open and indecent that an
office for the management of the
Geisha and artists was established,
called Kembansho. The director of
this office was authorized to exercise a
rigid control over these classes in the
performance of all their various pro-
fessional duties.
The different classes of prostitutes
in the Yoshiwara from its earliest days
seemed to multiply according to the
demands of the great variety of its
patrons. Most any kind of taste or
financial footing of visitors could be
satisfactorily served within the en-
closure of this great den of prostitu-
tion. The guest with 10 sen (5 cents)
from the lowest strata of the popula-
tion could get what he wanted, as well
as the man with 10 yen ($5.00) from
the upper crust of society. Competi-
tion and scarcity of money occasioned
frequent fluctuations in the value of
the commodity for s^le in this public
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mart of vice, but strange as it may
appear, the fees received by prostitutes
during the first century of the Yoshi-
wara averaged more than double those
of the present time. Some of the
inmates were classed according to the
size and location of the brothel they
occupied. Certain brothels with lat-
tice work in front and located in more
aristocratic quarters, were much higher
priced than others less favorably situ-
ated and equipped.
Inmates of the middle part of a
brothel were a grade-higher than those
of the side apartments. Those oc-
cupying large and medium-sized houses
were, of course, better paid than the
courtesans of the shops and barracks.
Some of the prostitutes could only be
exhibited in their cages, while others
like the «*Yobi-da8hi" and ''Chusan*'
were permitted to parade the main
street (Naka-no-cho) at will. In ad-
dition to favorable environment, per-
sonal charms and the glamour of costly
attire were attractions which enhanced
the price of the courtesan's favors.
The "Tayu'' for nearly a century
stood at the head of the prostitute
class, both in beauty and elegance of
attire. In 1642 there were 18 Tayu
in the Yoshiwara, but this class gradu-
ally died out, and in 1751 was extinct.
The fee of the Tayu was at first 6 yen
or about three dollars, but about forty
years later in was ' increased to 16
yen or eight dollars. The **Koshi-
Joro" were next in rank to the
*'Tayu," and their fee at first was 4
yen, but later increased to about ten
yen. A reaction of public opinion
against these extravagant charges
brought to the front another class
called *«3ancha-Joro," who reduced
the fee to about 2 J yen.
The superior tact of the class known
as «*Sancha-Joro," and moderate
fees required for their favors, rendered
them popular with guests snd gave
them a monopoly of the fieM/^^^ a
long time after the disappearwi^ of
the ««Tayu'^ and "Koshi-Joro;" but
the craze for change, something new,
and the not uncommon belief that
nothing is good that comes cheaply,
gave rise to a more pretentious class
of courtesans who were called "Yobi-
dashi." The most superior attraction
of this class consisted in the gorgeous-
ness of their wearing apparel. Long
robes of costly silk, with the hair ar-
tistically arranged and fastened with
hair-pins made of glittering tortoise-
shell, added to the dazzling beauty of
face and form, constituted charms that
rarely failed to captivate the multi-
tude. This class had the right of way
in all the fashionable quarters of the
famous abode of prostitution. But
those who dance must pay for the
music. Splendor of apparel costs
money, and this class knew how to
indemnify themselves for their outlay.
From twelve to sevetiteen yen, or from
$6.00 to $8.50, was agreed upon as
about the proper fee for a day and a
night's entertainment. When it is
understood that the '«Yobi-dashi"
maintained apartments elegantly ar-
ranged in all their appointments, and
were attended by two female pages,
two grown-up female servants, a man
carrying a lantern-box, a footman, and
an old woman who acts as chaperone,
the fee does not appear to be unrea-
sonable.
CHAPTER IV.
The higher class of courtesans, in
pursuance of a long-established custom
of the Yoshiwara, was entitled to from
one to three young female attendants,
called "Kamuro," according to the
grade they occupied. This honor was
a distinguishing feature of their rank.
The «'Tayu" and '*Koshi-Joro" were
entitled to two and three, while the
' *Sancha-Joro' ' were alloweJone. The
keeper of the brothel selected these
little girls and had them*:trained accord-
ing to their aptitude for the business.
If they displayed unusual talent or
other accomplishments which might be
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useful to the '* profession,'* they were
given special training in these lines.
The Eamuro served the courte-
sans to whom they were assigned in
various capacities besides accompany-
ing them in their promenades. The
prostitute who commanded the ser-
vices of the Kamuro was called Ane-
Joro. She supplied the Kamuro with
an outfit of clothing and paid all the
necessary expenses. In all the plans
of educational training provided for
the Eamuro, her future usefulness to
the profession was kept in view. If
the girl was dull and gave no promise
of future usefulness, she was neglected
and became a drudge in the brothel
service; but if she was bright and
attractive, with an ambition to advance
in this disreputable calling, she was
promoted a step higher, and after the
age of about fourteen became a
*'Shinzo" novitiate, who soon learned
to assume all the functions of the
prostitute class to which she was ad-
mitted.
The introduction of the Shinzo to
the profession was usually attended
by considerable ceremony and with the
exchange of suitable presents and
mutual congratulations among the
members of the circle she proposed to
join. As a general rule the "Ane-
Joro" whom she had previously served
gave her a helping hand preparatory to
her debut as a full-fledged member of
the profession. When the term of ap-
prenticeship as Kamuro expired and
the girl was ready to enter upon the
vocation of a prostitute, the master or
brothel-ke.eper who had trained her. as
a Kamuro and watched over her from,
perhaps, the age of seven to fourteen
years, would try to hold her in his
service by offering her parents or
guardians a certain sum of money for
a bill of sale, which was sometimes ac-
cepted, but at other times refused, in
consequence of better offers from other
brothel-keepers.
To circumvent this sharp practice on
the part of parents or guardians, the
brothel-keeper often secured a certifi-
cate of sale instead of apprenticeship ,
when he engaged the ^irl as a Kamuro.
This kind of traffic is, however, not
now tolerated by the government. In
all first-class brothels of the Yoshiwara,
and even the smaller houses, it has al-
ways been the custom to employ super-
vising matrons who have full charge of
all the details of their management.
These women are usually recruits from
the ranks of old and experienced in-
mates who themselves were beyond the
age of properly entertaining guests,
but know all the outs and ins of the
business. They were formerly called
*'Yarite," but now are known as
^'Obasan," a name answering to
*< Auntie" in the English language.
In the higher classed houses these old
veterans lead luxurious lives. They
are provided with nicely furnished
quarters with female lieutenants, al-
ways ready to execute their orders.
Of course, in the smaller establish-
ments the profits of the trade do not
justify this convenient method of
supervision, and the female manager is
not only compelled to give her per-
sonal attention to the numerous affairs
of the house, but often finds it neces-
sary to do a little private entertaining
in order to bring her revenue up to a
level with her personal expense ac-
count. The amount of remuneration
depended largely upon the orderly and
satisfactory treatment of guests and
the volume of business transacted, as
the income of the "Yarite" was
largely derived from commissions on
the money spent by guests and such
gratuitous offerings as their liberality
prompted. The management of the
brothels was not conducted without the
aid of men servants. In large estab-
lishments there were inside men and
outside men, night watchers, bath-
room men and general utility men. In
the smaller brothels there was no spe-
cial division of labor for the male
employes, nor were as many needed
to meet the requirements of the broth-
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Prostitution in Japan- Martin,
100
els. Besides, these men were not the
recipients of tips or gifts from guests
to any g^eat extent, as such marks of
favor were reserved mostly for the
courtesans or female attendants of the
brothel.
In the more pretentious establish-
ments, which command a large trade,
the services of a head clerk are needed
to successfully conduct the finances of
the house. This man, who is called a
*'banto," is an important perl^onage,
and commands the same respect ac-
corded the master of the brothel. He
has his regular office hours, and during
this time usually appropriates a large
share of the perquisites which in his
absence fall to his subordinates. His
income from all the different sources
within his reach amounts to a snug
little sum, which gives him considera-
ble prestige among the habitues of the
establishment in which he is employed.
Among the more conspicuous at-
taches of the Yoshiwara are the
clowns, or buffoons, known as *«Ho-
kan," and the dancing girls, or
"Geisha." No party or banquet would
be fully enjoyed without the presence
of these professional entertainers.
The more ridiculous their antics, and
the more all rules of decency are out-
raged, the more vociferously are their
performances applauded.
The **Hokan," or buffoon, was
formerly a more important person than
now. He lived mostly outside of the
Yoshiwara, and was more of an ama-
teur clown than a professional per-
former. He had other means of mak-:
ing a livelihood, but being gifted with
wit, musical talent and comical genius,
he was in demand at all places of
amusement. The better class of Ho-
kan, known as <<Zamochi,*' were highly
cultured, and mingled in the best cir-
cles. They enjoyed the confidence of
the nobility, and were often invited to
entertain their guests on social occa-
sions. The other class, called «*Taiko-
Mochi,*' like the present *'Hokan" of
the Yoshiwara, were less talented and
accomplished in the usages of polite
society. They were more vulgar than
witty, and were welcome only among
classes of similar tastes. When they
performed at public places of amuse-
ment their antics were suggestive and
revolting, often discarding every arti-
cle of clothing, they demonstrated
their contempt for decency.
The better class of **Hokan'* in
former times received a fee of 10 yen
($5.00) for a four hours' engagement,
but to show how this class of profes-
sionals has degenerated, the present
day *»Hokan'* does not receive for his
services more than 50 sen (25 cents)
to 1 yen (50 cents). The profession,
since the restoration, has dropped in
public esteem, even below the level of
the '* Geisha," or dancing girl. Both
classes of these professionals have de-
generated to the point where they
have to be kept under official surveil-
lance by the **Kembansho," or office
for regulating the affairs of the
"Geisha" and other professionals.
They cannot exercise their calling
without a license, and a small commis-
sion is levied on their fees by the
"Kembansho" for this privilege. If
the services of a "Geisha" are needed,
she is summoned by an official of the
Eembansho, who keeps a record of
the hours she is engaged, and calcu-
lates the amount of commission ac-
cordingly, on the basis of a fee of
12i sen per hour.
The ^'Geish's" functions are of a
somewhat variable and multiple char-
acter. She is expected to dance, play
on the guitar, or sing, as the occasion
requires, and when she is not profes-
sionally employed, she is required to
make herself generally useful in the
household of the brothel where she
temporarily resides. They have no
permanent quarters, as their occupa-
tion takes them from house to house.
It is difficult to understand how any
woman of the least self-respect can
entangle herself in the mashes of
brothel-house procurers. But these
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infamous pimps do a thriving business
not only in Tokyo, but in all the great
metropolitan centers of the world.
Wherever poverty and the promiscu*
ous mingling of the sexes co-exist,
there is an inviting field for the vil-
lainous emissaries of prostitution.
In former times in Tokyo girls were
bought and sold for prostitution al-
most as openly as the buying and sell-
ing of cattle, but now, this vile busi-
ness is conducted on a different plan,
along lines that conceal the violation
of law.
The **Zegen** (procurers) late in
the eighteenth century became so bra-
zen in their operations that the Toku-
gaV^a government in 1792 was com-
pelled to issue the following edict :
Among those people living in this city who
make it their business to find positions for
men and women desiring to obtain employ-
ment are parties known as ze^en or naka*
tsugi. The plan of action adopted by these
individuals is to engage women tor a specified
number of years at certain fixed wages,
although at the time, there is in fact no open-
ing offering. In the written memorandums
of agreement entered into, it is provided thar
even should the women thus hired be em-
ployed in such disgraceful or low positions as
meshintori (lower class prostitutes kept in
inns under the guise of servants) menial serv-
ants,or in anyothercapacities whatsoever, they
shall have no grounds for raising objections
or complaints of any kind on that account.
Under these circumstances it is not usual for
zegeft to keep women on their hands for long,
and if no suitable situation be found within a
short time, they sell and transfer the girls to
other zegen for a certain sam of money. The
zegen also prolong the period of service con-
tracted for with the result that the parents do
not know when to expect their daughters
back. In this manner the whereabouts of
many women are lost, and their parents or
relatives are compelled to apply to the au-
thorities to search for and discover them and
cause their restitution. It is also reported
that sometimes zegen extort money from
parties seeking relatives, and from the pro-
prietors of brothels, and thus matters are
arranged and compromised privately without
referring them to the authorities. These prac-
tices are tantamount to traffic in human be-
ings and are hiejhly reprehensible, therefore
the profession of zegen or naka-tsugi i« hereby
prohibited. This law is to be strictly ob-
served.
Four years later the following noti-
fication was issued :
(1) When a brothel engages a new courte-
san through the medium of a professional
Kuchi'ire no mono (a person who finds situa-
tions for would-be employers), full inquiries
shall be privately instituted as to whether the
woman has been kidnapped or otherwise, her
birthplace, status, position, etc. Also as to
whether she is a real or adopted child of her
reputed parents. Inauiries shall also be made
as to the status, residence, etc., of her surety.
These matters must be thoroughly investigated
previous to entering into a contract of engage-
ment; the inauiries are to be made through
the medium of third parties, and not from the
said middleman himself; and if the woman be
actuall/engaged, the above-mentioned details
shall be entered into the nanushi's book. The
term of engagement arranged must not exceed
twenty years.
(2) The profession of zegen and naka-tsugi
having been prohibited in the fourth month of
the fourth year of Kwansei (the year of the
**Ox**) on the application of interested parties,
the authorities rendered the following decis-
sion:
Whereas, heretofore there have been numer-
ous instances of zegen and naka-lsugi having
signed and sealed documents as sureties for
courtesans under the pretense that they were
relatives of the women, it is hereby decreed
that, on and after the fifth month of the pres-
ent year, when the period of service has ex-
pired (as mentioned in the separate bonds of
guarantee handed to their masters), the ex-
courtesans shall not be given over to their
sureties, but to their own actual blood rela-
tions, and it is further ordered that the pro-
prietors of brothels are to assist the time-ex-
pired women in the matter of placing them in
the charge of such actual blood relations, as
aforesaid.
Should any zegen residing within the pre-
cincts of the Yoshiwara receive applications
direct from ^omen seeking employment as
couitesans, such zegen shall conduct the ap-
plicants to a brothel for the purpose of intro-
ducing them to an employer. When engage-
ments are finally concluded, the zegen shall
not (as formerly) seal the agreements, inas-
much that he is only permitted to act as a
mere introducer between the parties.
(3) Should the number of middlemen in the
Yoshiwara be limited, the profession would
become a monopoly, and to prevent the sell-
ing and buying of the good-will of the trade,
as well as to prevent any dishonest practices,
an agreement was lodged by each middleman
with the nanushi. The latter has been in the
habit of reminding the middlemen of the con-
tents of this contract once in every month, and
obtaining their signatui'es each time in proof
of his having done so. Of late, persons ply-
ing a smilar profession have appeared in the
vicinity of the Yoshiwara, but have remained
outside the enclosure. This is contrary to the
notification, and makes it difficult to exercise
proper control over them, therefore they shall
be compelled to move into the Yoshiwara un-
der pain of having the exercise of their pro-
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GenitO'Urinary Anatomy— Lewis.
aoi
fession suspended. Henceforth, all persons
desirous of carrying on the business of a mid-
dleman shall only be allowed to do so inside
the gates of the quarter.
After the promulgation of. the fore-
going decrees by the government, the
infamous traffic in girls was somewhat
restricted to the Yoshiwara, but the
zegen (procurers) employed agents
outside to co-operate with them in
prosecuting their nefarious trade, who
adopted such methods as enabled them
to evade the provisions of the new
laws.
Under the new plans of procedure
the efforts of the government were
thwarted at every step, and the **busi-
ness*' of the procurer was equally as
prosperous as under the old law.
Finally, in 1872, patience ceased to
be a virtue, in the opinion of the gov-
ernment, and a decree was issued
granting absolute liberty to prostitutes
throughout the jurisdiction of the em-
pire.
It must be said, to the credit of the
prostitute^ that they were not slow to
take advantage of their freedom. In
a few weeks after the issuance of this
decree thousands of these unfortunate
women left the places of prostitution
and reformed their lives.
A PLAIN TALK ON MATTERS PER-
TAININQTO OEMTO-URINARY ANAT-
OMY, PHYSIOLOGY AND
DISEASES.
Bt Db. BRANsroBD Lewis, of St. Loxiis,
Professor of Gonlto-Urinary Surgery, Marion-Sims-Beaa-
mont Medical College; Consultant in Gteni to-Urinary
Surgery to the Female Hospital, Bebekah Hos-
pital, etc.; Member of American Association
of Qenito-Urinary Surgeons, American
Medical Association, Etc.
There is probably no subject more
far-reaching in interest, or about which
there is more speculation, than that
which £ propose to discuss tonight.
While I haven't the experience to jus-
tify me in speaking from the stand-
point of the gentler sex — never having
been a girl — I have been a boy ; and I
know 8ome of the things they do and
say. I know it is a sad and backward
boy who does not think on sexual sub-
jects before he is old enough to wield
much of an influence in this world's
affairs. And boys talk on the subject;
and what nonsense they do talk ! And,
for that matter, what nonsense they
expound on such subjects, even after
they get to be men ! Reeling off theo-
ries that are profound but far-fetched.
But there are two good reasons why
this should be: the lack of informa-
tion that boys get from sources truth-
ful and reliable; and, on the other
hand, the abundance of misleading in-
formatioii that they get from sources
either questionable or abominable;
from such sources as other boys or,
worse than that, the quack literature
and *• marriage guides," so easily ob-
tainable by confiding youth.
In the first place, ostrich-like, we
bury our heads in prudery, and refuse
to discuss such subjects with the in-
quisitive youth ; and we allow him to
grow up with distoi-ted ideas and worse
habits. Instead of eirt^nding to him
the helping hand of advice and com-
fort, we leave that to be done by the
most devilish-minded of society — ^the
harpies of charlatanism, who feed on
the fears and superstitions of such be-
nighted individuals. A condition not
understood by them is interpreted as a
condition diseased. For instance, nat-
ure has made provision against the
squeezing of one testicle against the
other by hanging the left one lower
than the right. A nervous boy una-
ware of this provision, reads in one of
the advertising circulars that one of
the sure signs of *'lo8t manhood" is
the hanging of one testicle lower than
the other. He looks up the matter
on himself and finds, alas! that he is
afflicted in that way. A guilty memory
of past indiscretions is sufficient ex-
planation to him why the condition ex-
ists. Still, to be perfectly certain about
it and give himself the benefit of the ■
doubt, he studies the subject further
— examines those noble distributors of
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Original Articles.
intelligence, the daily newspapers, and
finds something like the following,
which is to be seen in nearly every
publication of the day :
*«Te8t Your Kidneys.
Let some morning urine stand for
twenty-four hours in a glass or bot-
tle. If then it is milky or cloudy or
contains a reddish, brick-dust sedi-
ment, or if particles or germs float
about in it, your kidneys are dis-
eased.'*
No loop-hole of escape is left for
him; he is certain, now, that he has
Bright's disease as well as ''lost man-
hood.'* For, be it known, every urine,
healthy or unhealthy, contains mate-
rials in solution when passed that later,
when the urine cools, precipitate to
form a sediment of various sorts — of
phosphates or urates — things that have
nothing more to do with Bright' s dis-
ease than a cat with spectacles. The
devilish cunning of, the villain who
writes the, advertisement is apparept ;
he fixes matters for everybody who"
urinates; and there are very few of us
who can get along without attention to
that detail of life. Is it a wonder that
we read such additional items of news
as the .following, which appeared in the
same issue that contained the ''kidney
test" alluded to:
"Suicide Due to Causeless Fear."
Andrew J. Teggin, an artist, whose
pictures have been exhibited at the
Academy of Design, took chloroform
today, and died soon afterward at the
New York Hospital. Teggin 's death
was the end of five years' dread of
Bright's disease. Though eminent
specialists had assured him he had no
symptoms of the disease, he persisted
in believing that he was doomed to die
from it, and this so worked on his
mind that he killed himself rather
than wait for the end he felt sure
would come."
Knowing that these unfortunate con-
ditions exist, it would seem proper
that some provision be made to rem-
edy them. Parents should not only
have plain and candid conferences with
their children on these subjects, but
should send them to the family doctor,
who could easily put them on the right
track and help to keep them there by
subsequent encouraging advice and in-
struction. It will be my endeavor
this evening to lightly touch on a num-
ber of these topics — sufficient, at least,
to serve in dissipating some of the If;
fanciful dreams and harmful rubbish (^i
that hang about them.
Anatomy and Physiology.
The genitO'Xirinary system is divis-
ible into two sets of organs — the gen-
ital organs and the urinary organs.
The genital organs serve for the repro-
duction of the species, carrying on the
sexual function ; and the urinary or-
gans serve to make and get rid of the
urine, acting as one of the sewer sys-
tems of the body, as it were.
Urinary Organs, — These consist of
the kidneys, ureters, bladder and the
urethra.
The kidneys are two rounded bodies,
located in the "small of the back,"
under the ribs. As the blood flows
through them they extract from it cer-
tain waste-products, for which the
system has no longer any use, and
which would be injurious, indeed, if it
were retained longer.
Ureters. — The outlet for the escape
of the urine is found in the ureters,
two small tubes running from the kid-
neys downwards and joining the blad-
der at its lower portion. By these
ureters the urine is conducted into the
bladder.
Bladder. — The bladder is a reser-
voir for the temporary retention of the
urine — for holding the urin^ between
the times of urination — and a very
useful organ it is.
Urethra. — From the lower end, or
"neck," of the bladder the elastic
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CenitO' Urinary a
canal called the urethra leads, passing
through the prostate, the cut-off
muscle and the penis. The urethra
completes the channel for conducting
the urine from the body; and the
smaller opening at its outer end per-
mits of the projection of the urine in
a good stream that adds to the con-
venience of the act. But the urethra
has another office to fulfill. If all
urethras should become stopped up
permanently, this fact would shortly
become apparent in the depopulation
of the world. That is, the urethra
Pig. 1. — The kidneys, areters and bladder of
the male (Morris).
must also conduct the semen to the
outer world or into the vagina of the
woman.
Genital Organs and Seminal Chan-
nel. — The semen is a mucilaginous-
looking tluid that contains the life-
giving bodies called spei^matozoa, which
are the fecundating elements of man.
They resemble ordinary tadpoles in
both appearance and movements.
These spermatozoa are manufactured
in the two bodies called testicles, which
hang in the bag called the scrotum.
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Original Articles.
climax of intercourse or night-emis-
sion. '^Normally" is used intention-
■lu
Tf
ir»+ h
airck m
far*.
IS
f
e
iS
It
y
d
e
t
d
i-
h
t
e
t
but as a matter of fact, there are cer-
tain vastly important features about
its make-up that are not usually l^nown
or understood, not only by the frater-
nity of pharmacy, but often by the
medical profession, which lack of
knowledge on the part of both contrib-
utes very largely to their inability to
really cure gonorrheas with the numer-
ous *'sure cures" so much in vogue,
and also makes them think they have
cured such cases when they have only
stopped the discharge, which is no evi-
dence of cure at all. These features of
the anatomy of the urethra I am espe-
cially anxious to make clear to you.
At a point just in front of the pros-
tate is a muscle that surrounds the
urethra like a puckering-string. It
contracts around the. urethra with a
tight grip at all times, day and night,
except when it is relaxed by some
special influence, such as the act of
passing water. At all other times it
is tightly closed, preventing the in-
voluntary escape of the urine from the
bladder. It has a very important oflSce
to fulfill. If it should go on strike,
wet trousers would be quite the fash-
ion. It is the main constrictor or
sphincter for the bladder — that is, it
is the principal muscle upon which the
bladder depends for helping to retain
the urine during the interims between
urination. It prevents water from
passing outwards through the urethra,
although the water may make strong
pressure against it and endeavor to go
past it. The same thing is true with
water going in the opposite direction.
If, for instance, we apply a small
syringe against the outer opening of
the urethra (the meatus) and inject
water into the urethra, it goes back
readily until it reaches the muscle,
where it finds a strong barrier against
its further progress; it is prevented
from going further, none of it reach-
ing the back part of the urethra. This
muscle is, therefore, a dividing muscle
for the urethra, dividing it into two
unequal parts, a long front part and
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Genito-Urinary Anatomy— Lewis.
206
a short back part. It is, therefore,
called the cut-off muscle of the urethra.
If it would act in a similar obstruct-
ive manner to the infectious inflamma-
tion called gonorrhea, we would be in
a position to admire its capabilities
more than we are. But it does not.
Gonorrhea is an inflammation of the
urethra caused by a microbe called the
gonococcus (Fig. 4), that takes root
at the front end of the urethra and
shortly thereafter propagates enormous
numbers of its own kind, at the same
time causing the inflammation that
makes it the aggravated disease that
we recognize under that name. The
inflammation travels backward; and
is not at all overawed by the muscle;
it gets past the muscle in by far the
large majority of all cases of gonor-
rhea.
In order to cure gonorrhea we must
first kill out the hordes of gonococci
that infest the urethra, and then allay
the inflammation. We cannot kill them
by using internal medicines, such as
sandal oil or copaiba; gonococci must
be attacked by direct application of
remedies that kill them, without at the
same time injuring the tissues. Sup-
pose we give injections into the urethra
of the best of such remedies, using the
small syringe ordinarily employed for
this purpose; the fluid passes back-
ward along the front urethra and medi-
cates all of that part of the canal, pos-
sibly killing all of the gonococci lying
in that part, but does it pass back into
the rear part of the canal where there
are also hordes of gonococci and active
disease? By no means. The cut-off
muscle prevents that; so that, not-
withstanding the patient's devoted at-
tention to the treatment prescribed,
heroically swallowing the boluses of
horrid medicines and giving himself
the injections with energy and fre-
quency, he reaches only the front part
of the diseased urethra, failing to ap-
ply any remedy at all to the back part.
Perhaps he does much good for the
front part, killing out the gonococci
there and stopping the discharge ; but
on the discontinuance of the medica-
tion there is renewed infection of the
same membrane from the organisms
coming from the back part of the
urethra, and renewal of discharge as
active as ever. He may go through
this sequence time after time, becom-
ing more discontented all the time,
because he does not seem to he ''cured
completely.*' The fact is he has never
been cu7'ed at all; he has never had
treatment to the whole involved area.
The lessening of the discharge was
only a misleading indication of im-
provement, not an indication of cure.
It was as if a man had two broken
arms and expected to be cured by hav-
ing a splint placed on only one of
them. Except, in this instance, it is
not so favorable, since the arm has a
natural tendency to get well, while the
gonorrheal infection has no such benev-
olent disposition. Gonococci may re-
main in the back part of the urethra
for months or years — in fact, indefi-
nitely — and with the property of be-
FiG. 4. — Gonococci.
ing reawakened into activity and either
causing renewed gonorrhea in the
individual himself, or of being con-
veyed to his partner of an intercourse,
endowing her with gonorrhea, months
or years after he had supposed him-
self well. In this way many innocent
wives are infected, often to the chagrin
and heart-felt grief of their husbands
who had supposed themselves free
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200
Original Articles
from disease for months or years be-
fore. They did not know that the
absence of active discharge was no
reliable indication of their restoration
to health.
These facts, also, throw a flood of
light on the subject of * 'three-day
prescriptions'* for the "sure cure*' of
gonorrhea. In most instances where
such combinations appear to be suc-
cessful, it is either a non-gonorrheal
case (simple urethritis), or the injection
has simply caused a temporary stoppage
of the discharge, as previously ex-
plained. The patient thinks he is ac-
quiring and curing numerous separate
cases of gonorrhea, when, as a matter
of fact, he is simply having revivals of
the same old case, reducing its activity
each time and stopping the discharge,
but never curing it.
Therefore, you can see that in order
to get an effective cure for urethral
gonorrhea it is not so much a matter
of the selection of the proper remedy,
as it is the proper application of that
remedy. All of the parts involved by
the gonorrheal process must be treated
before we can expect a cure. We must
treat the back part of the urethra as
well as the front part; we must kill
out the gonococci lying back there,
and also allay the inflammation there.
This can be done and is done every
day, and without harm or pain to the
patient, by those who study these sub-
jects; and they establish a cure that
does away with Noeggerath's doleful
axiom: **Once a gonorrhea, always a
gonorrhea." Therefore, my druggist
friend, I advise you to dispense your
medicines for killing gonococci as
ordered or requested by the physician,
but also to dispense with the endeavor
to cure cases of real gonorrhea with
such futile measures as '*sure-cure"
injections, which, at the best, can only
be a form of ''absent treatment,*'
since it never quite reaches the part af-
fected. These sure cures are beautiful
theoretically but disappointing prac-
tically.
Nor can we stop with even this far-
reaching claim for the extended possi-
bilities and the serious nature of gon-
orrheal infection. We must remem-
ber that there are other organs than
the front and the back urethra that are
subject to the inroads of the gonococ-
cus. You have observed that the pros-
tate is in intimate relationship with the
urethra, surrounding it at its posterior
end. Gonococci go from the urethra
into the prostate, infect its glands and
tissues and make gonorrheal prostatitis.
They enter the little ejaculatory ducts,
from which the semen escapes, and
pass up into the semen bags (ves-
icles), causing the same gonorrheal
process there; and when we under-
stand how isolated and secluded is this
lodgment for them, we will again be
impressed with the utter fallacy of
trying to cure such wide-spread infec-
tion with three-day injections, It is a
problem on which many of the best
men of the world have spent years of
labor: is it to be expected that our
nearest friends, those who look on
gonorrhea as being "nothing worse
than a l?ad cold," wise as they are on
the subject of three-day cures ; is it to
be expected that they have solved the
problem with the superficial knowledge
that they have acquired from a few
personal experiences? They not only
do not solve it, but they are playing
with edged tools, the misuse of which
may have the most disastrous conse-
quences to the misguided friends who
take their advice. 'Tis not the patient
alone who is concerned, but the ques-
tion involves the future wife, the fam-
ily, the very foundation on which the
state is built !
Bugbears.
I wish to give you short explana-
tions of some of the staple bugbears
of quack literature — those maladies
which we learn from circulars are all
horrible beyond conception, but at the
same time are all "cured without re-
sort to the knife," provided we put
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Genito-Urinary Anatomy— Lewis.
207
our trust (and our money) in the keep-
ing of the noble philanthropist whose
name appears at the bottom of the ad-
vertisement.
Sterility means inability to fecun-
date or impregnate. Possibly, from
some reason, spermatozoa are not
manufactured, or perhaps the chan-
nels through which they travel from
the testicles to the urethra are ob-
structed, preventing the transmission
of the spermatozoa to the female ; al-
though intercourse is repeated time
and again, and apparently successfully
in every respect, the ejaculated semen
does not contain the spermatozoa that
are necessaiy for the fertilization;
sterility is the result. Either the man
or the woman may be at fault.
Impotence. — A condition that is usu-
ally much more harrowing to the pa-
tient is that of impotence ; inability to
carry out the act of sexual intercourse,*
and without reference to the question
of impregnation. In order to effect
satisfactory intercourse on the part of
the male, there must be erection of
the penis. This state of erection is
constituted by the filling of that organ
by relatively enormous quantities of
blood, rendering it so tense that rigid-
ity is the result. This is maintained
in the intercourse for a varying length
of time, until the nervous crisis called
ejaculation is experienced, freeing the
semen-bags of their contents and also
the penis of its pent-up blood, after
which there is subsidence again to the
normal state of flacidity.
There are various causes for inabil-
ity to acquire a sustained erection,
briefly divided into physical and men-
tal. Depressing or agitating impres-
sions are calculated to dispel one's
amorous inclinations; likewise are
those of fear or distrust, etc. It is
for a similar reason that the very be-
lief itself in one's inability to perform
the act in a commendable manner often
intimidates and defeats the candidate
at the very outset. Here is where the
mental effect is dominant and disas-
trous. The candidate is humiliated
where he would like to be enthralled.
And he felt all the time that it would
be so. And that's the very reason that
it was so. Relief from his foreboding
will bring about relief from the appar-
ent defect. But is he likely to be re-
lieved by sermons on **lost manhood"
and such distorted imaginings in liter-
ature? Hardly.
But there are, as I mentioned, phys-
ical causes for impotence, to relieve
which they must be sought out in an
intelligent manner by a medical attend-
ant — not by the imaginative brain
of the uninformed patient. Empiric-^
ally prescribing or taking the various
sexual stimulants, is a very injudicious
way of getting at the relief. Often
such remedies act injuriously instead
of beneficially ; they add to congestion
of the organs that, may be already con-
gested or inflamed. The best policy
in such cases is to hunt out the cause,
whether physical or mental, and re-
move it. Often it is unrecognized and
uncured gonorrhea, possibly of long-
standing.
Spermatorrhea and masturbation
are names that derive their horror
chiefly from the use that quacks and
charlatans make of them, scaring the
unfortunate and misinformed into the
belief that they are suffering from the
effects of the one or the other, and
that they will never'again be able to
satisfactorily breathe the air of hal-
lowed society until they have taken a
course of the charlatan's treatment
** without Recourse to the knife." It
is an unfortunate fact that nearly all
boys are destined to pass through a
more or less protracted period of im-
becility and general cussedness, in
which they turn with unerring cer-
tainty to tastes and acts that are inju-
rious and debasing, rather than bene-
ficial and elevating. They upset cus-
toms and conventionalities : they break
furniture; they masturbate, and fi-
nally get to smoking cigarettes. A
lawyer-friend of mine gave it as his
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GenitO'Urinary Anaiomy— Lewis.
209
opinion — and he ought to know — that
all boys ought to be put in a barrel
and fed through the bung-hole from
the time they are seven until they are
twenty. While I do not participate to
the fullest extent in this belief, I do
think that something ought to be done
with our boys. They ought to be in-
structed, as I intimated before, in the
elementary truths, at least, of sexual
matters being inculcated into them
by the parents or the family phy-
sician ; and they ought to be circum-
cised^ — the permanent and tempting
invitation to masturbation in the form
of the foreskin being removed in
their early infancy, before sexual
feelings are experienced, and the vi-
cious counsel of other boys is received.
Moses realized the vast benefits to
be derived from this procedure and
displayed his far-sightedness in exact-
ing it as a religious rite among his
people, else it would never have been
80 universally followed by them. The
Gentile, with the long pendant fore-
skin (Fig. 5) does not know what it is
to have a clean penis, dry and hygi-
enic, even though he wash it every
day; the natural secretions are held
under the foreskin become infected
and decomposed, leading to conditions
that are anything but healthy and de-
sirable. One such is shown in the il-
lustration of venereal warts (Fig. 6);
a matter purely of long foreskin and
lack of cleanliness. There is some
reason, then, and excuse as well, why
boys should be boys, endowed as they
are with anatomical conditions, as
well as traits, calculated to lead them
astray. But, notwithstanding this.
Fig. 5.— Abnormally long and tight fore-
skin.
Fig. 6. — ^Venereal warts, resulting from snch
a foreskin
Fig. 7. - Hydrocele.
Fig. 8. — Varicocele before operation.
Fig. 9.— The same after operation.
there is reason, for retaining some
faith in the ultimate favorable outcome
of American boys. If all of them who
masturbate are destined to permanent
invalidism and degeneracy, where do
our governors, our senators and our
presidents come from? Such boys
cannot all goto the House of Delegates !
As to spermatorrhea, that is merely
one of the various symptoms of gen-
ital disorder that when it is present
should be jrelieved, like the others, by
the cure of the condition that lies at
the bottom of it. ** Spermatorrhea"
means loss of semen ; but, more often
than not, the supposed loss of semen is
only an escape of prostatic mucus, in-
dicative of irritation in the prostate in-
stead of the generative organs. So
that while deserving of attention and
relief, it has none of the horrible as-
pects dwelt on by some writers on
these topics.
Hydrocele means an abnormal col-
lection of water (serum) in a certain
part of the scrotum (Fig. 7). It has
nothing to do with venereal disease,
and is ordinarily relievable by either
tapping and injection of certain solu-
tions, or by open incision methods.
Varicocele is a dilatation of the
veins in the scrotum (Fig. 8) that
surround the cord, often accompanied
by undue pendancy of the scrotum,
which hangs down to such a degree
that no support is given to the testicles ;
giving a diagreeable, dragging-down
feeling that is sometimes very uncom-
fortable or even painful. While it is
relievable with comparative ease and
certainty by operation (Fig. 9), it does
not always require operation or even
treatment ; if of only mild degree, the
wearing of a good scrotal suspensory
may answer all needs. No medicines
applied either locally or taken inter-
nally will cure varicocele or hydrocele.
(to be continued.)
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Original Articles.
AN BTIOLOQIC FACTOR
SD QENITO'URINARY
OlSBASBS*
Frautm ANN, of Munich, Germany.
of bacteria exist on the
8 has been demonstrated
), Bordoni-Uffreduzzi,
I others. Among them
diverse kinds of cocci
r. W. Dammann (1) has
: kinds which are un-
, and to which he has
owing names: B. epi-
'. luteus liquefaciens;
flavescens; micrococcus
xcording to Guenther
ere can, be found on the
bacteria which cannot
pathogenic.
ref ore, maintain that the
ally found on the exter-
no role in the derma-
mic bacteria, as an etio-
tack the outer and inner
m without or within.
173) has shown that in
infection by the staphy-
rule, occurs through the
dn, and that, therefore,
ugh the unbroken skin
ntly, however, infection
through injuries of the
hey be only microscopic
:his way infection may
rough the blood and
Is into the innermost or-
gans. On the other hand, it is a fact
that through an internal infection or
internal morbid process of a bacterial
nature, germs are carried to the skin
and eliminated in this manner. Ac-
cording to Guenther (I. c.) a few oases
of this kind have been observed.
That these bacteria may produce (as
a modification of the internal affection)
new, local morbid changes, can be
easily conceived.
The same holds good for bacterial
metabolism, analogous to the derma-
toses, which are caused by the stomach
and intestines. Many diseases, as scar-
let fever, measles, etc., of which noth-
ing definite is known, can be explained
according to the above.
The attempt to find a specific, etio-
logic bacterial cause for skin and sex-
ual diseases — particularly for such the
contagious nature of which has been
demonstrated, in spite of the discovery
of the various micro-organisms — has
been successful only in comparatively
few affections.
The specific germ for one or another
affection has been found; not so for
the great majority, although we must
assume that for entire groups of der-
matoses there exist either a specific
micro-organism t)r one producing va-
rious pathologic pictures.
I have compiled from the works of
Baumgarten, Joseph, Kaposi, Lang,
and from current literature, the fol-
lowing table, giving the bacteria found
in the various affections:
COCCEN.
3 pyogenes
Albus.
Bac. fluoresc. liq-
uefac.
Albus.
Impetigo contagiosa Fox.
Furunkel.
Carbunkel.
Foudroyante Gangraen (Four-
nier).
der Genitalhaut (Buergner).
Impetigo Bockhart.
Pemphigus infantum.
Sykosis (simplex) coccogena.
the original German MS., for American Journal of Dkrmatoloot, by Dr. Gnstavus M.
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Bacteria as an Etiolocic Factor— Trautm an n, an
COCCEN— Continued.
+ Albus.
Toxine.
Eccema (Bockhart).
4- Cereus albus.
Streptococcus pli-
catilis.
Lemaistre.
Perleche (Pourleche).
Angulus infectiosus,
Faulecke.
+ Streptococcus.
Pneumonic diplo-
coccus.
Erysipel.
-f- Streptococcus.
Tetracoccus.
Variola.
Varicellen.
Staphylococcus pyogenes|od. Bac. Unna.
Acne (Lomry).
Impetigo Bockhart.
Sykosis (simplex) coccogena.~
Pemphigus 'infantum.
Eccema (Bockhart).
Foudroyante Gangraen (Four-
nier).
der Genitalhaut.
(Lang u. Sorgo.)
Staphylococcus aureus al-
bus.
4- Aureus. i
Streptococcus pi i- Perleche.
catilis.
Lemaistre.
Staphylococcus cutis com-l
munis Sabourand. 1
Pityriasis capitis.
Seborrhcea corporis.
Staphylococcus hsemor-
rhagicus.
bei einer von Schafon ueber-
tragbaren Blasenkrankheit.
Pneumonic diplococcen.
-f- Streptoco ecus,
staphyloc. aur.
Erysipel.
-f Streptococcus.
Morbilli (Cornil et Babes).
Mikrococcen.
ident. ? mit Strepto-
coccus.
Orientbeule.
ident.? mit Staphy-
loc. aureus.
+ Albus.
Scarlatina (E. Klein, Jamieson,
Edington).
Pemphigus infantum.
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dl2
Original Articles
BACILLEN.
Bac. anthracis.
Haut-Milzbrand.
Bac. diphtheriee.
+ Toxine.
Haatdiphtherie und exantheme
(serum).
Bac. typhi.
+ Toxine.
typhoese Hautgeschwuere,
Roseola.
Bac. rhinosklerom.
Rhinosklerom.
Bac. leprae.
Bac. tuberculosis.
Milzbrand aehmliche ba-
cillen.
Toxine (— ?).
I Lepra.
Scr oph ul Oder m a .
Lupus vulgaris.
Tuberculosis verrucosa cutis.
Ulcus tubercul. cut.
Tuberculoese Tumorcu, der
Haut.
^ Lichen scrophulosorum.
Acne cachectica.
Lupus erythematodes.
:S ; Pityriasis rubra Hebra.
^i
+ Coccen (Peckel-
haring u. Wink-
ler).
ident. mit Bac. der
B uttersaeure
gaehrung (Schat-
tenfroh)
Beri-Beri (Ogata).
Gasphlegmone (E. Fraenkel).
Bac. pyocyaneus.
Ekthyma gangraenosum.
Bac. Matzenauer.
Hospitalgangraen .
Elaschen bacillus Uuna.
lEccema seborrhoicum.
Bacillus mit duennen En-
den.
Elephantiasis erythem. ^gypt.
Bac. Unnae.
nach Lomry
ylococc.
albus.
Staph-
pyog.
Acne.
Bac. fluorescens liquefa-
ciens.
Strepto. bacillus Unna.
Foudroyante Gangraen (Four-
nier).
Ulcus molle.
Bac. Ducrey.
lUlcus molle.
Bac. von Niessen.
ILues.
Bac. Lustgarten.
Bac
Justin de Lisle et
Louis JuUien.
Lues.
Lues.
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J
Bacteria as an Etiolocic Factor— Trautmann. ais
BACILLEN— Continued.
Bac. Paulsen.
ILaes.
Bac. M. Joseph u. Pior-{
kowski.
Lues.
Coccen.
lErysipeloid (Roaenbach).
JLues (Aufrecht).
Dach Ogata Bacillen. Beri-Beri (Pekelharing
I Winkler).
Morococcus Unna.
ISeborrhoische Schuppen.
Mikrococcus Sabourand. I Toxine.
jAIopeoia.
Tetracoccen.
+ Staphylococc. p,
aur.
Streptococcen.
Variola.
Streptococcus pyogenes.
+ Staphylococc.
pyog. aur.
Pneumococcen.
+ Pneumococcen.
+ Mikrococcen.
+ Staphylococc.
pyog. aur.
Tetracoccen.
nach Kolisko U4
Chotzen secun-
daer.
Secundaer.
Erysipel (Fehlelsen).
Morbilli.
Scarlatina.
Variola.
Lues (Kassowitz u. Hoch-
singer).
Mykosis fungoides.
Impetigo (simplex) vulgaris
Unna.
Streptococcus plicatilis, + Staphyloc. pyog.
Lemaistre. aur.
Staphyloc. cereus
alb.
Perleche.
Gonococcus Neisser.
iGonorrhoea.
If we look first of all at the staphy-
lococci, we will observe that the va-
rious kinds occur sometimes alone,
sometimes several together, and some-
times in conjunction with other bac-
teria.
1. The staphylococcus pyogenes au-
reus alone is met with in impetigo
contagiosa Fox, furuncles and car-
buncles.
It has also been demonstrated in
gangrene foudroyante (Fournier) of
the genital skin by Buergner.
According to Lomry, the staphylo-
coccus pyogenes albus is found in acne,
while Unna advances his acne bacillus.
E. Klein (4, p. 81) has described
the staphylococcus hsemorrhagicus,
which is very closely related to the
staphylococcus pyogenes aureus and,
perhaps, an identical coccus with the
one described by Mocard.
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This organism produces gangrenous
mastitis of sheep, and has been found
in a pustular dermatitis of the hand,
observed in Malton, North England,
caused by contagion with the hemor-
rhagic edema of the vulva of sheep.
2. The staphylococcus pyogenes
aureus and albus conjointly are found
in impetigo Bockhart and in pemphi-
gus infantum (acutus neonatorum con-
tagiosus).
Almquist produced with the staphy-
lococcus pyogenes aureus alone the
latter disease, and named it micrococ-,
cus pemphigi neonatorum.
According to Lang, this coccus is
apparently different from the ordinary
staphylococcus pyogenes aureus only
by a lesser virulence.
3. Both aureus and albus, further-
more, occur in sycosis (simplex)
coceygeus. Both, together with their
toxins, can produce a typical eczem,
according to Bockhart, E. Bender and
V. Gerlach.
4. In so-called perleche are found
the staphylococcus pyogenes aureus,
the cerus albus and the streptococcus
plicatis Lemaistre.
5. In contradistinction to the above
findings, Lang (according to a publi-
cation by S. Sorgo) demonstrated the
staphylococcus pyogenes albus and the
bacillus fluorescens liquef aciens in gan-
grene foudroyante of the genital skin;
6. As regards the streptococci, they
are met with in a series of affections.
But also with these, one must consider
whether they are the direct producers
of a disease or only secondarily car-
riers of infection.
For it is very probable that they can
play their infectious role far easier on
apart of skin, already diseased, than on
healthy integument. As they are met
in various infectious diseases we must
choose between the following ques-
tions, viz. : are they the one cause of
various diseases, or are they possessed
of but an accidental importance in the
presence and principal effect of the un-
known pathogenic germ, not yet dis-
covered?
Fehleisen's streptococcus produces
erysipelas. We know from experience,
however, that other bacteria also pro-
duce the same morbid process.
According to I. Rosenbach, Passet
and others, in regard to the morpho-
logic and culture features, no differ-
ence can be established between the
ordinary and Fehleisen's streptococ-
cus. Besides, Jordan (5) has demon-
strated in two cases of erysipelas the
staphylococcus pyogenes aureus. Other
cocci, as for example the pneumococ-
cus, produce erysipelas.
One could, perhaps, pronounce such
cases of erysipelas as are produced by
other bacteria than Fehleisen's strepto-
coccus as not genuine, nevertheless
the sj'mptomatology and course are
alike, so that clinically the term ery-
sipelas is justified.
Lang calls attention to the difference
which has been claimed to exist be-
tween Fehleisen's and the ordinary
streptococcus, consisting in this: that
the former produces erysipelas, the
latter suppuration. This difference is
nullified by experiments which have
established the fact that the strepto-
coccus alternately can produce both
princesses.
Just as here the same picture is pro-
duced by different micro-organisms,,
so we can consider whether, on the other
hand, the same bacterium depending,
perhaps, on its degree of virulency,
may not produce diverse pathologic
phenomena. The findings in morbilli,
scarlet fever and variola justify the
consideration of such a hypothesis.
According to Baumgarten (6, p»
385), the cocci which have been dem-
onstrated to exist in the lungs of those
suffering from measles, by Cornil and
Babes (7), may be either the strepto-
coccus pyogenes or the pneumonia
diplococcus of Fraenkel-Weiohselbaum .
According to the same author, who
bases his opinion on the observations
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made by Loeffler, Heubner, Bahnd and
others, the micrococcus found by
E. Klein (8^, Jamieson and Edington
{9) to circulate in the blood of men
Buffering from scarlet fever, may be
the streptococcus pyogenes.
Garre has isolated the streptococcus
pyogenes in variola, while Guttman
has found in the same disease and
varicella the staphylococcus pyogenes.
Other authors have isolated tetracocci,
which are found on the normal skin.
The chain cocci found in mycosis .
fungoides (Rindfleisch, Auspitz), ac-
oording to Koebner, Ziegler and others,
are also nothing else but pyogenic
streptococci. Baumgarten interprets
them as an accidental colonization.
Pyogenic streptococci are also seen
in impetigo vulgaris Unna, in per-
leche ; in addition to the above-named
bacteria the streptococcus plicatilis.
The finding of streptococci in a se-
ries of diverse affections speaks more
for a secondary importance.
Cocci, for which a specific role has
been claimed, have been found: in
•erysipeloid, by Rosenbach, a coccus
with which he could produce this af-
fection; in beri-beri, by Pekelharing
and C. Winkler (16), a certain coccus
which has been prepared by Lacerda
Ogata (11) with the bacillus of malig-
nant pustule. In plague, the inocula-
bility of which has been demonstrated,
various authors have found micro-
cocci; in the seborrheic scales Unna
found morococci. Sabourand (12)
holds responsible for all forms of
alopecia the toxins of a micrococcus
with which he could produce falling
out of the hair in animals.
We, therefore, find various bacteria
in one and the same disease, while ob
the other hand the same micrococcus
(often alone) appears in various dis-
eases.
A similar condition is observed with
the bacilli, although several are fixed.
I need but remind you of the b. an-
thracis, diphterise, typhus, which ap-
pear on the skin — the bacilli of rhino-
scleroma appear to be certainly pathog-
nomonic. For tuberculosis of the skin
we have to consider scrophuloderma
ulcerosum, lupus vulgaris, tuberculosis
verrucosa cutis, ulcus tuberculosum
cutis, and the tuberculous skin tumors,
in which the tubercle bacillus can be
demonstrated, though in small num-
bers.
Bacilli similar to those of malignant
pustule, as already mentioned above,
have been found in beri-beri, and by
E. Fraenkel in gas phlegmon. Schat-
tenfroh considers Fraenkel's find iden-
tical with the bacillus of lactic acid
fermentation.
The question raised by Schimmel-
bush (14, p. 23), viz. : whether the ba-
cilli pyocyanci can penetrate into the
tissues of the body of man and develop
pathogenic propeities, and which was
left unsolved by him, has been an-
swered in the affirmative by F. Hitsch-
mann and H. Kreibich (13), who have
demonstrated the bacilli in the tissues
of patients afflicted with ecthyma
gangrenosum.
Matzenauer (Lang, 15, p. 242) has
established a bacillus for hospital gan-
grene, respectively for the related
gangrenous genital ulcer, the culture
and inoculation of which yielded in-
sufficient results. In seborrheic ec-
zema Unna's bottle bacillus plays a
role.
The bacillus fluorescens liquefaciens
has already been mentioned above in
connection with foudroyant gangrene
(Fournier) of the genital skin (Lang).'
In erysipeloid elephantiasis which
occurs in Egypt, and which should be
differentiated from the lymphorrhagic
form, Ines (16) found bacilli with
thin ends.
Even the bacterial products of meta-
bolism have been considered by au-
thors. According to Bockhart, E.
Bender and V.Gerlach, typical eczema
can be produced with the toxins of
staphylococci alone or in connection
with staphylococci. According to the
French school, the products of raeta
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holism of the tubercle bacilli are the
cause of the so-called tuberculides.
To these belong lichen scrophulosum
(scrophuloderma papulosum), acne
cachectica, lupus erythematodes and
pityriasis rubra Hebra.
As regards the genital diseases, we
are positive about the gonococcus of
Neisfeer. Ducrey has discovered a
bacillus in ulcus molle, and later Unna
has found a strepto-bacillus, which
Krefting has studied in the pus of
bubo. According to Andry, both are
identical.
Bacteriologically syphilis has long
been of special interest to us, and
numerous experiments and discoveries
have been published.
According to Baumgarten (6, p. 392),
Aufrecht and others have early de-
scribed forms of cocci.
EassowitzandHochsinger (17) have
found in the blood vessels of children,
suffering from hereditary syphilis, a
streptococcus, which has been demon-
strated by Kolisko (18) and Chotzen
(19) to originate from a secondary in-
fection.
Much more numerous were the find-
ings of bacilli. After a long series of
such, which, however, did not stand
the test, the belief prevailed that Lust-
garten's bacillus was the true and cor-
rect one. As is well known, the same
has also been demonstrated in the
smegma preeputii.
Lehmann and Neumann (20, Vol. ii,
p. 375) say: **No bacteriologist be-
lieves today in Lustgarten's bacillus, at
least as regards its relation with
syphilis;" while Migula (21, ii, p. 497)
believes that one should not go that
far.
The publications of Niessen raised a
lot of dust, and have been repeatedly
attacked; this after discoveries of
bacilli in syphilis have been reported
by Eve and Lingard, Disse and Tagu-
chi. They were followed by Justin de
Lisle and Louis Tullien (22 and 24),
also by Paulsen (23).
The findings of tnese micro-organ-
isms were based on their presence Id
the blood of syphilitics and in syphil-
itic products.
The fact that lues is hereditary has
long ago suggested the theory of germ
transmission.
As regard tuberculosis, Baumgarten
(6, p. 103) cites lani (26, p. 522^^
who has demonstrated tubercle bacilli
in the sperma of phthisics whose
genitals were normal.
Thus we can conceive a hereditary
tuberculosis. Baumgarten further-
more calls attention to the so-called
Flecksucht (Pebrine disease) which
attacks the silk-worm epiJermically,
caused by the microbion Pebrine:
**The Pebrine parasites enter from the
sick butterfly in the cells of the ova
and seed, which carry the disease germ
in the insect now developing from
them, so that it also becomes attacked
by the Pebrine disease, the parasite of
which grows with the growing cell of
the ovum."
This fact is positivelj' established,
and analogous to it we can conceive
the process of transmission of heredi-
tary syphilis. Max Joseph and Pior-
kowski (26) chose for their experi-
ments the sperma of syphilitics, and
have succeeded, after inoculating ster-
ilized human placenta, in cultivating
colonies of bacilli grouped like fences.
The same bacilli were also found di-
rectly in luetic sperma, in the blood of
syphilitics and in syphilitic products^
while the results in healthy men, or
such who had been infected a long-
time ago or in whom treatment has
produced an apparent cure, were all
negative.
In comparison with the other dis-
coveries the last named seem to have
the best chance of solving the bacteri-
ologic problem of syphilis.
A final decision, however, at present,,
must be withheld until further exami-
nations and experiments are made.
Sabourand (27), in regard to the
importance of streptococci and staphy-
lococci in theetiology of the derma-
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Bacteria as an Etiologic Factor— Trautm an n. aiT
tesesy holds responsible three of their
kiads, viz. : the streptococcus identical
with that described by Fehleisen, the
staphylococcus aureus and the staphy-
lococcuH cutis communis.
If we survey our arrangement of
the cocci, we must conclude, that even
according to the same, these three
varieties play the chief role.
There must be, however, a strict
differentiation between their char-
acter as an etiologic factor, as for ex-
ample in impetigo, sycosis coccogena,
erysipelas, etc., and as a secondary
find as in morbilli, scarlet fever, etc.
As regard the other cocci, with the
exception of the gonococcus, partially
their exisience are but secondary, par-
tially their identity with the above
named must be accepted.
While we observe one and the same
species of cocci in various diseases, we
notice that the Bacilli have the char-
acteristic property of either produc-
ing one special disease or to accom-
pany such an one.
The proof of their relation to the
large number of dermatoses as an
etiologic factor is settled only in a few
instances, in otherstheir presence justi-
fies only a supposition of their etiologic
role, which must be acceptded as un-
certain at best.
This especially holds good for the
Joseph-Piorkowski bacilli, which, ac-
cording to the latest experiments,
decidedly oppose the assumption of
their causal relation to lues.
Therefore, in spite of untiring re-
searches, the bacteria as causative
factors of the affections under discus-
sion have been established but in a few
instances.
The reason for this may be that per-
haps the largest part of the dermatoses
are due to mechanic, nervous, patho-
physiologic, chemic and parasitic
causes.
LITERATURE.
(1) G. W. Damtnann: Vorlaeufige Mitteil-
ungen ueber einige Mikroorganismen der nor-
maleo Haut. Brit. Med. Joarn., 16. vil. 1892.
(2) C. Guenther: Einfuehrnng in das Sta-
dium der Bakteriologie. Leipzig. 1898.
(3) Garre: Portocfaritte der Medicin. 1886.
(4) E. Klein: Ueber einen fuer Mensch
« und Thier pathogenen Mikrococcus, Stapbylo-
coccns bsemorrbagicus. Centralblatt fiier
Bakteriologie. IV. 1897.
(6) Jordan: Archiv fuer klin. Chirurgie.
1891, Band 42.
(6) Baumgarten: Lebrbncb der patbolog.
Mykologie. Braunschweig. 1890.
(7) Cornil et Babes: Les Bacterics. 2 ed.
1886.
(8) E.Klein: Tbe Etiology of scarlet fever.
Proceedings of the Royal Society. Vol. xlxx.
(9) Jamieson and Edingtpn: Brit. Med.
Jour., 1887, Juni 11, Aug. 6.
(10) Pekelharing und Winkler: Mitteil.
ueber die Beri-Beri. Deutsche med. Wochen-
schr., 1887, No. 39.
(11) Ogata: Muenchen aerztl. Intelligenz-
blatt, 1886, No. 47.
(12) R. Sabourand: Malad. du cuir chev-
elu. I. Les mal. seborrheigues. Paris. 1902.
(13) P. Hitschmann und K. Kreibich: Zur
Patbogenese des Bac. pyocyanens Und zur
Aetiologie des Ekthyma gangraenosum. Wi-
ener klin. Wochenschr., 1897, No. 50.
(14) C. Schioimelbusch: Anieitung zur
aseptischen Wundbehandlung. Berlin. 1892,
(16) Ed. Lang: Lehrbuch der Hautkrank-
heiten. Wiesbaden. 1902.
(16) Ines: Mikroorganismen bei den Wund-
infectionskrankheiten des Menschen. Wies-
baden. 1884.
(17) Kassowitz und Hochsinger: Wiener
med. Blaetter, 1886. No. 4.
(18) Kolisko: Wiener med. Blaetter, 1886,
Nos. 4 und 6.
(19) Chotzen: Vierteljahrsschr. f. Derma-
tol, u. Syph. 1887. I.
(20) Lehmann und Neumann: Atlas und
Grundriss der Bakter.
(21) W. Migula: System der Bakterien.
Jena. 1900.
(22) Justin de Lisle et Louis Jullien:
Deutsche med. Wochenschr., 1901, No. 29.
(23) Paulsen: Biolog. Abt d. aerztl. Ver-
eins. Hamburg. Sitz. 14. I. 1902. Muen-
chen, med. Wochenschr., 1902, No. 9.
(24) von Niessen: Betracht. ueber de
Lisle's und Jullien*s Syphilisbacillen. Klin,
therap. Wochenschr., 1902, No. 14.
(26) Jani: Ueber das Vorkommen von
Tuberkelbacillen im gesunden GenJtalapparat
bei Lnngenschwindsncht, etc. Virchow's
Archiv, Band ciii, 1886.
(26) Maxjosephund Piorkowski: Berliner
klin. Wochenschr.. 1902. Nos. 13 u. 14;
Deutsche med. Wochenschr., 1902, Ncs. 60-62.
(27) Sabourand. Paris: Die Rolle der
Streptococcen und Staphylococcen in der
Aetiologie der Hautkrankheiten. 69. Jahres-
vcrs. der Brit. med. Gesellsch. in Ct el ten-
ham. Brit. J6um. of Dermatology, 1901, Sep-
tember.
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rUB TBCHNIQUB OF PROSTATECTOMY.
Bt Niosolas Ssnn, M. D., Chicago, lUlnois.
The following is an expression of
Dr. Nicholas Senn's views on the tech-
nique of prostatectomy: The ques-
tion as to the most feasible route by
ivhich to attack the diseased prostate
hsLS not been definitely settled. The
suprapubic method has many weighty
-advocates, and for a time was deemed
the easiest, most efficient and safest.
The perineal route has, however, been
.given a more extended trial, and a very
large experience appears to have de-
•cided in its favor. From an anatomic
standpoint, the perineal operation is
•certainly the most rational of the two,
and will undoubtedlj'^ survive the test
of time. The removal of the enlarged
prostate does not always meet all the
indications in the case operated on.
Few cases come to the surgeon in
which the bladder is intact in conse-
<juence of the mechanical obstruction
or infection, hence in the majority of
cases it becomes necessary to estab-
lish free drainage after the removal of
Hxe prostate for the purpose of initiat-
ing a successful treatment for the co-
•existing complications. Every sur-
geon who has had an extensive experi-
-ence in perineal prostatectomy has
Jearned that not all enlarged prostates
-can be removed by enucleation. There
are cases in which the diseased organ
must be removed by morcellement. It
is a rule in surgery, which it is always
well to bear in mind, and that is to op-
erate as little as possible in the dark
in important anatomic localities, and
this rule applies with special force to
perineal prostatectomy. In obese sub-
jects and in cases of very large pros-
tates it is often exceedingly difficult to
bring the parts to be removed within
reach of the index finger. It is under
these trying circumstances that the op-
erator will appreciate the advantages
of an incision that will expose the pros-
tate freely and bring it within easy
reach of the finger or the instruments
required for its removal. Very little^
is gained by attempts to render the
prostate more accessible by intraves^
ical instrumental pressure, and such:
efforts are by no means always harm-^
less. The danger from hemorrhage
and accidental wounding of the peri-
toneum is reduced to a minimum by
resorting to an incision that will ex-
pose the prostate in the freest possible
manner to sight and touch. I have=
attempted to do this by combining the
median incision with two lateral in-
cisions, representing in outline an in-
verted capital Y. The median incision
is made in the usual way, laying bare
the membranous portion of the urethra.
The lateral incisions are carried from
the lower angle of the median to a
point half way between the anal mar-
gin and the tuberosity of the ischium,
cutting through about the same struct-
ures as are involved in the lateral op-
eration for stone in the bladder. The
wound is next deepened largely by the
use of blunt instruments and all hem-
orrhage arrested as it occurs, main-
taining throughout the entire opera-
tion practically a bloodless field. This
will give the operator an opportunity
to recognize and identify the tissues as
he proceeds with the dissection. In
this comparatively bloodless way the
rectum is detached until the membran-
ous portion of the urethra and the
lower segment of the prostate can be
distinctly seen and felt in the apex of
the deep triangular wound. By using
narrow, flat, deep retractors the rec-
tum is pushed backward and the"
wound margins are retracted laterally,
thus exposing freely the parts con-
cerned in the next step of the opera-
tion. I then proceed as follows: On
a grooved staff, which is now inserted
into the bladder, the membranous por-
tion of the urethra is incised and the
grooved director of Wheellhouse in-
serted into the bladder. Withdrawing
the staff and using the director as a
guide, the prostatic part of the urethra
is dilated with the left index finger.
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The Technique of Prostatectomy—Senn.
210
which, after it enters the bladder,
serves as a blunt hook with which the
prostate is drawn gently downward and
forward into the wound. The capsule
of the gland is next incised transversely
4Uid with the opposite index finger enu-
cleation of the left lobe is commenced.
This part of the operation is usually
•asy, sometimes difficult and not infre-
quently impossible. Recklessness and
undue violence are to be carefully
avoided. Enucleation is often facili-
tated by grasping the lower part of
the prostate with my bullet forceps or
some other grasping instrument on
which traction is made during the pro-
cess of enucleation. I seldom attempt
to remove the prostate in its entirety.
Occasionally this can be done, but
usually it will be found much easier to
remove only one lobe at a time. After
the removal of the left lobe the right
index finger is inserted into the blad-
der and the right lobe enucleated with
the left. If it is found impracticable
to remove the prostate by enucleation
morcellement must be resorted to.
The finger in the bladder is almost in-
dispensable in operating by this
method. With it the parts are brought
within easier reach, and it serves at
the same time as a valuable guide for
the use of the cutting and traction in-
struments. With grasping forceps
portions of the gland are seized, when
the necessary traction is made by an
assistant, while the surgeon does the
•cutting with blunt-pointed scissors
well curved on the flat. Complete
prostatectomy in such cases is not
necessary, but enough tissue must be
removed to insure a free outlet for the
urine and to guard against a recur-
rence of obstruction from the same
cause. I am decidedly in favor of a
preliminary cystotomy in performing
perineal prostatectomy, as it greatly
facilitates the removal of the gland by
enucleation or morcellement, and in
the majority of cases it becomes a ne-
cessity for the treatment of complicat-
ing affections of the bladder. It is
preferable to incise the urethra and
take advantage of such an openins:
into the bladder during an operation
than to tear it accidentally, as is so
often done when operators undertake
a perineal prostatectomy without a
perineal cystotomy. I invariably drain
the bladder by inserting a soft rubber
drain with two oval fenestra near thd
vesical end. The drain is fastened in
the lower angle of one of the lateral
incisions with a suture which includes
the outer margin of the wound. The
perineal wound is drained with a strip
of iodoform gauze, which is brought
out on the side of the rubber drain.
The balance of the incision is sutured.
The bladder is kept practically empty
by siphonage by connecting the peri-
neal drain with another piece of rubber
tubing, making the connection with a
glass tube. Throiigh this rubber drain
the bladder can be washed out daily
with appropriate antiseptic solutions.
The iodoform gauze drain should re-
main for at least five or six days, as its
presence in the wound is of the great-
est value in preventing infection by
leakage of septic urine. The bladder
drainage must be continued until the
condition of the urine is sueh as to
warrant suspension of intravesical
medication.
Dropsy is a marked and obstinate
symptom of chronic parenchymatous
nephritis. The face is pale and puffy,
and in the morning the eyelids are
oedematous. The anasarca is general,
and there may be involvement of the
serous sacs. Anasarcin tablets, prop-
erly administered, will produce aston-
ishing results.
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Selections,
SELECTIONS.
CIRCUMCISION AND FLAOBLLATION
AMONQ THE FILIPINOS.
While I was in the Philippines in
1899 and 1900, and particularly while
stationed at San Miguel de Mayumo,
Calumpitand Hagonoy, in the province
of Bulacan, Luzon, I had exceptionally
good opportunities, through the assist-
ance of two educated and liberal na-
tives who spoke Spanish— one a mes-
tizo and the other an indio — for learn-
ing about some of the less generally
known customs of the Filipinos.
The indios -- those who have the
least admixture of non-Malay blood —
are, as a rule, extremely secretive and
distrustful of foreigners, whom they
call ^^Gastila^^' a word derived from
the Spanish ^'Castellanoj'' which
means Castillian or Spaniard. This
term is applied by the Philippine indio
to all white men. The great body of
the natives are as secretive toward for-
eigners as are the Chinese. Priests
and others who have spent their lives
among them, say that it is impossible
for any one to understand their char-
acter unless he has played with them
in childhood and lived his life as one
of them. T^hey have a great many
ancient pagan rites and superstitious
customs, of which some are derived
from the rites of various religious sys-
tems and some are of secular origin.
Some of those which had their origin
in religious observances have long since
lost all religious association, while
others which formerly had no connec-
tion with any system of religion what-
ever have become embodied in a sort
of semi-Christian semi-pagan worship.
Most of the Tagalos, who are nomi-
nally Christian and Catholic, observe
not only the rites of the Catholic
Church, but many pagan rites and cus-
toms as well. Some of these latter
are purely tribal in their prevalence,
while others are observed throughout
the archipelago and have come to hold
an almost national meaning and asso-
ciation for many of the natives. Even
the fact of the existence of some of
the most prevalent of their customs is
unknown to many white men who have
spent considerable periods of time in
contact with the native.
Though I have read, I think, every
book descriptive of Philippines pub-
lished previous to 1901 in the English
language and many of those published
in Spanish, I do not remember to have
seen any mention of circumcision in
any of these books, and the only men-
tion of flagellation which I recall was
in Foreman's very comprehensive book
in which he mentions that a Spanish
sea captain told him that be had seen
flagellations in one of the more south-
ern islands. Extremely few white men
have seen flagellants in the Philippines^
though flagellation is prevalent. I be-
lieve that the following is the first pub-
lished description of circumcision and
flagellation as performed in ihe Phil-
ippines:
Circumcision is a very ancient cus-
tom among the Philippine indiosy and
so generalized that at least 70 or 80
per cent, of males in the Tagal coun-
try have undergone the operation •
Among them, being uncircumcised is
looked upon as a defect, so much so
that children of both sexes cruelly
taunt those who have reached the age
of puberty and are still uncircumcised.
They apply to them with intent to in-
sult the term ^^supvt^'^ which orig-
inally meant "constricted*' or "tight, "^
but has come to mean "one who can-
not easily gain entrance in sexual in-
tercourse." When American troops
first came to Hagonoy and bathed in
the river, the fact that they were un-
circumcised was a subject of great
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$El.ECTJONS.
aai
^ssip in the market place. It is not
known where the natives got the cas-
tom — possibly from the Mohammedan
Moros of the southern islands. The
Moro men are all circumcised by their
^^panditas^^' or priests, as a religious
ceremony necessary to make them eli-
gible for matrimony, but among the
Tagalos, who are professed Catholics,
the operation has no religious associa-
tion. Neither is it among them done
on account of any idea of cleanliness,
but from custom and disinclination to
be ridiculed. The friars were not
able to root out the custom, as it was
an ugly subject to treat of from the
pulpit. Among the Jews the opera-
tion is done on the tenth day after
birth, but among the Philippinos —
both Mohammedan Moros and Chris-
tian Tagals — it is practiced at the age
of from eight to twelve years. In the
Tagal country it is called *'Huli^^' and
is performed as follows: The opera-
tor provides a polished piece of wood,
sufficiently curved and of such length
that when one end of it is driven into
the ground the boy to be operated
upon can '*squat on his hams"- prac-
tically sit on his calves — and insert the
free end of the stick, which is pointed,
between the head of his penis and his
foreskin. After the foreskin has been
drawn over the point of the apparatus,
which is called ^^tamurung^'' the op-
erator (also in the squatting position)
picks up a sharp knife and places it so
that the edge rests lengthwise on the
foreskin. Then, holding the knife in
place with one hand, he gives it a sharp
blow with a stick of wood or a joint of
cane held in the other. If he does not
succeed in entirely exposing the head
of the penis at one blow, he gives a
second or even a third. Guava leaves,
which are astringent, are afterward
applied in the form of a paste made by
chewing the leaf, or in the form of a
powder prepared by burning them,
and the wound is bandaged. The
dr/dssing is changed daily. While the
wound is fresh the patient cannot wear
trousers on account of the pain they
would cause, and he wears instead
merely a cloth dropped from his
middle.
Flagellation was a custom probably
taken from the early Spanish friars,
but it has been so discouraged of late
years by the church that it is per-
formed only in smaller villages of the
interior and in the outlying barrios of
the larger towns, more or less secretly,
away from the sight of white men.
But, notwithstanding the fact that the
existence of flagellation among the
Filipinos is practically unknown to
foreigners, it is extremely prevalent
during Holy Week. On Holy Thurs-
day in 1890, while at Hagonoy in Bula-
can Province, having learned about the
flagellants from a native, I took
some pains to see something of them,
and riding out alone at some risk suc-
ceeded in seeing a number.
Although the Philippine flagellants
are called ^^penitentes*^ the flagellation
is not done in penance, but as the re-
sult of a vow or promise made to the
deity in return for the occurrence of
some wished-f or event, and the '*peni-
tentes*' are frequently from the most
knavish class. A person falls ill, for
example, and he promises the deity
that if he gets well he will perform
penance of such and such kind, during
such and such days of Holy Week, for
so many years. Or if he has an enemy
whom he wishes to get rid of he vows
that if this enemy dies, he will drag a
ball and chain, or flagellate himself,
or perform some other specified pen-
ance on Holy Thursday every year
during the rest of his life. Back of
the small chapel called '*rm7a«," which
exists in every village, begins his pen-
ance. With his face covered to prevent
recognition, stripped to the waist, and
with no clothing but loose, thin, white
cotton trousers, one finds him stand-
ing with his arms folded, his head
bowed forward and his body bent,
while an everyday-looking native slaps
him on the back till the blood comes
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SELECTIONS.
into the skin. Then he is spatted with
a piece of wood with little metal points
in it till his back is macerated and the
blood runs freely. Then he starts out
on a long day's journey from viaita to
visita. He is certainly a w«ird and
barbaric spectacle as he silently and
slowly stalks along with covered face,
swinging from side to side a cord into
the end of which is braided a bunch of
sticks about the size of pencils, which
strike his bare bleeding back a loud
sound at every step and macerate it so
the blood oozes down and soaks his
white trousers. At short intervals he
prostrates himself in the dust, utters
some unintelligible jargon, possibly a
prayer, while the everyday-looking
citizen spats him on the back and on
the soles of the feet with a flail as he
grovels there. At intervals the out-
landish figure goes through grotesque
contortions or progresses by hand-
springs. Whenever he comes to a
stream or ditch be plunges into it, and
whenever he reaches a visita he grovels
before it and spends much time in
prayer. One may see these flagel-
lants lying prostrate in the dust for
long periods at a time. But the chief
picture one carries in mind is an erect
native with covered face, bare bloody
brown back, and blood-stained trou-
sers, stalking slowly forward alpng
the bamboo -fringed roads to the
rhythmic accompaniment of the swing-
ing scourge, while from every house
for miles comes a weird monotone lilt
which represents the chanting of the
passion. — Lieutenant Charles Norton
Barney, U. S. A., Medical Depart-
ment, in Journal of the Association of
Military Surgeons.
ACNB SIMPLEX.
Every general practitioner is ex-
pected to keep himself informed of the
latest advances in all the wide range of
medicine and surgery, including, of
course, all the special branches. Fort-
unately he is not expected to be thor-
oughly conversant with all the refine-
ments of technique ; nor is he expected
to be able to apply all the methods of,
for instance, modern gynecological
surgery, plastic and abdominal. But
he is expected to know when they
should be employed, and it is his prov-
ince to assist the afflicted patient, or
her family, in the choice of a compe-
tent person to employ them. All this
being demanded of the general practi-
tioner, is it not just that the specialist,
for instance, in gynecology and ab-
dominal surgery, should also be ex«
pected to keep well informed regard-
ing the concomitant ills from which
hi$ patient may suffer? We certainly
do not wish to encourage the soi disant
'•universal specialist" who styles him-
self a specialist in whatever ailment
any individual patient may exemplify,
but merely to encourage a broadening
of the specialist field of observation, if
not of practice.
Among the minor concomitant ills
by which women with pelvic disease,
especially functional disease, are an-
noyed, perhaps none is more frequent
than acne simplex, or, as it is fre-
quently called, acne vulgaris. And,
perhaps there is no minor ailment in
which both the general practitioner
and the gynecologist fail more abso-
lutely in aiding the patient. Leaving
out of consideration the young girls at
puberty, it is not at all difficult for any
gynecologist to recall many cases in
which he has been consulted regarding
minor functional pelvic disordei^s, not
because they were themselves so
troublesome, but in the hope that
through them the real cause of the an-
noyance, acne, might be reached. In
this point of view we'have been con-
siderably impressed by a symposium
upon the etiology and treatment of
acne pmblished in the Transactions of
the American Dermatological Associa-
tion, and recently mentioned in the
Annals.
Dr. Gilchrist, of Baltimore, after
most careful and painstaking investi-
gation, is certain that acne is due to.
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228
the presence of a specific bacillus
which he terms the bacillus acnes. The
pustular form is apparently due to
a mixed infection of the bacillus acnes
and the staphylococcus pyogenes.
But what most interests the gyne-
cologist and practitioner is the treat-
ment of this condition. The paper
upon thia subject was contributed by
Dr. Fox, and was abundantly dis-
cussed by many of the most prominent
dermatologists in America.
The most useful method of treat-
ment in severe cases seems to be the
curettage of all lesions with a broad,
sharp curette, thus covering a large
area at one seance. Of equal import-
ance is the extraction of all comedones,
and the opinion is advanced that if
careful search, with a lens if neces-
sary, is made for incipient comedones
their extraction thus early will do much
toward the prevention of future acne
lesions.
Massage, not according to any fixed
rules of manipulation, but merely by
gently pinching the skin of the af-
fected area, is also considered of great
value, and as a topical application sul-
phur in some form is acknowledged to
be the most eflScacious. Many argue
strongly against the employment of
unguents in any form, and suggest
that in massaging the face powdered
pumice-stone be used to keep the fin-
gers from slipping. We have recently
seen very happy results which seem
more rational from the substitution of
aarphur for the powdered puniiice.
Laxative and general hygienic meas-
ures are of well-known and undoubted
advantage. Every woman having a
concomitant pelvic disease and acne
has a right to expect that both condi-
tions receive proper treatment, or that
she at least be aided to the proper
treatment if the gynecologist or prac-
titioner do not feel competent to em-
ploy it, and to this end we wish these
articles might be read by all. — Annals
qf Gynecology and Pediatry.
AN EPIDEMIC OP TRICHOPHYTOSIS OF
THE SCALP IN SCHOOL CHILDREN
Werther describes an epidemic of
ringwonn in school children, seven-
teen out of thirty being affected. The
main points of interest being :
1. The different clinical forms in
some of the cases.
2. The identity of the trichophyton
as shown by cultures.
3. The botanical peculiarities as
shown in cultures, especially in the
method of ''Plaut."
4. The successful inoculations of
pure culture in animals and on man.
The source of infection could not be
positively established, but the first case
developed in a boy on his return from
a vacation. The author mentions cat-
tle as a possible source of infection,
although near the end of his article he
identifies the growth as Sabouraud's
tricophyton of the cat. He recom-
mends \he ingenious method of Plaut
(Muench. Med. Wochensvhr.^ 1902,
No. 5, S. 208), of placing the suspected
hairs between a slide and a cover-glass,
which is placed on moist blotting-paper
in a Petri-dish. The aerial forms of
growth from the tricophytic hair give
a very typical picture in from six to
eight days. The endogenous spores
or terminal chlamydospores render
identification easy. The dry cultiva-
tion of the tricophytons frees it from
contamination by bacteria and pus*
cocci, and affords an admirable method
in studying the trichophytons.— Wer*
ther, in monatshft. f. Prkt. Dermt. —
Exchange.
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New publications.
NEW PUBLICATIONS.
%.
Treat
DiSSASES OF MSTABOUSM AND NXTTBITION. ]
Db. Carp von Noobden. Published by K.
& Co., New York City. 1903.
So many diseases and pathological
conditions spring from disorders of
metabolism and nutrition that ample
grounds for elaborate study of these
processes are apparent to every physi-
cian.
The author, in this little volume,
takes up that troublesome disease de-
scribed as membranous catarrh of the
intestine, or colica mucosa, and thor-
oughly discusses its pathogenesis and
treatment. His lucid presentation of
this disease and the rational treatment
outlined should be carefully studied by
the general practitioner, who so often
has to deal with it.
A System ov Phtsiolooio Thebapeutios. A prmctical
exposition of the methods, other than dnu giving,
useful for the prevention of disease and in the treat-
ment of the siok. Edited bj Solomon Solis Cohen.
A. M., M. D., Senior Assistant Professor of Clinical
Medicine in Jefferson Medical College. Volume X,
Pneumotherapy, including ^rotherapy and Inhala>
tion Methods and Therapv. By Dr. Paul Louis Tis-
sier. One-time Interne of the Paris Hospitals, As-
sistant Consulting Physician to Lamneo and Lari-
boisiere Hospitals, Chief of Clinic in the Faculty of
Medicine of the University of Paris. Illustrated.
Philadelphia: P. Blakiston^s Son Sc Co., 1012 Wal-
nut street. 1903.
The above volume contains a philo-
sophical presentation of a most impor-
tant branchof physiologic therapeutics,
which has not been sufficiently recog-
nized and studied by the practical
workers in the medical profession. As
a therapeutic agent, the air cannot be
ignored. Its relation to health and
disease is too intimate and constant to
be overlooked. At this time the open
air treatment of consumption empha-
sizes the necessity of investigation
along the lines of this volume. Part
1st treats the whole subject of eero-
therapy exhaustively, whilst Part 2d
takes up inhalation methods and
therapy. It must be borne in mind by
the reader that physiologic therapy
does nbt antagonize wisely directed
pharmacotherapy. They are allied
sciences of equal value to the pro-
gressive members of the medicalguild.
Pbaotioal Hand-Book of the Pathology of the Skin.
An introduction to the histology, pathology and
bacteriology of the skin, with special reference to
technique. By J. M. H. Maoleod, M. A., M. D , M. B.
0. P., Assistant in the Dermatological Department,
Charing Cross Hospital; Physician to the Skin De-
partment, Victoria Hospital for Children. With
eight colored plates and thirty-two black and white
plates. Philadelphia: P. Blakiston's Son & Co.,
1012 Walnut Street. 1903.
This most excellent book furnishes
the groundwork upon which cutaneous
pathology rests. The author elabo-
rates all of his views of skin lesions
from the anatomo-pathological basis.
In this way he avoids much of the
present embarrassment connected with
nomenclature. He discusses the de-
velopment, general characteristics and
minute structure of the cutaneous tis-
sues, and then describes the pathologic
changes which they are liable to
undergo. He devotes due attention
to the various methods for histological
examination of the different cutaneous
structures. His views on the causal
relation of micro-organisms to skin
diseases are rational and conservativo.
He maintains that Koch's postulates
must be accepted in determining this
question. This book also has the
merit of being the first and only one
on the special lines mapped out by
the author. It is the outcome of pro-
longed labor and research, and will
prove a useful guide to students and
physicians who wish to gain a thorough
knowledge of thin branch of medicine-
Price, $5.00 net.
Human Anatomy. By Samuel O. L Potter, M A.,
M.D. Seventh edition, revised and enlaised. Price,
80 cents net. P. Blakiston's Son & Co., Philadelphia.
1903.
The present edition of the above
quiz-compend has been rewritten, en-
larged by the addition of 82 pages,
and brought completely up to date.
This expansion of the text allows room
for a more thorough elaboration of
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riTi ri/kVi|j 1 1
m
Which yieMs thirty times lU vol-
ttme of «• nascoot oxygon *' noor
to the cooditiofi of ••ozone,'*
is daily proving to physicians, in
some ne^ way, its wonderful efficacy
in stubborn cases ol Bozema^ PBoriuaiBf 8mlt Rheum, Itet,
Barber* a Itob, Bryaipelaa, Iry Poiaoning, Ringworm,
Herpea Zoater or Zona, afe. Acne, Bimplea on Face
are cleared up and tlie pores healed by NYIMOZONE and OLYCOZONC
in a way that is
mac:ical. Try this
treatment ; results
will please you.
Full method of treat.
Dient In my book.
•* The Thenpeuticml
Applications of H]r>
drozone and Glyco>
sone * • ; Seventeenth
Edition, 339 paRes.
Sent free to physidaos
oa fequest.
Prepsrad only hf
Cbenlst and Graduate of the *• Ecole Centrale dea
Arts et Manu&ctures de Paris '» (France)
57-59 Prince Street, New York
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essential details without interfering
with the condensed form of statement
heretofore adopted. As it now stands,
it will meet all the wants of the med-
ical student in preparing for his ex-
aminations. The total number of
illustrations has been increased from
117 to 138, and the tables and plates
heretofore appearing in an appendix
are now placed in the text.
LuoOTHiBAPT. By 0. E. RoOBBS. M. D. Published by
the Metropolitan Press, Seattle, Wash.
The above is a very interesting book.
Its style is clear and forcible. The
author is very enthusiastic over the
results he has obtained from light
treatment in a great variety of dis-
eases. He employs the combined rays,
and claims they penetrate deeper and
are adapted to a wider range of patho-
logical conditions than the actinic
rays alone. His views are optimistic,
but appear to be corroborated by a
large number of clinical tests. He
claims that lucotherapy is applicable
to all forms of inflammation, and exerts
its therapeutic effects by vibratory
force; that it is bactericidal, tonic,
counter-irritant, analgesic and hyp-
notic in its action. Undoubtedly light
therapy has a bright future, but it
will take time and patient investigation
to estimate its full value.
DI8BA8B8 OF THB SKIN. By JaT F. SHAMBBBO, A. B.,
M. D. Third edition, revised and enlarged with 106
illastrations. Philadelphia: P. Blaklston's Son &
Co. Price, 80 cents net. 1903.
This little book will serve as a use-
ful guide to the medical student and
convenient reference work to the
busy practitioner. Its teachings, while
in touch with the latest modern re-
search, are practical and conservative.
Especial attention is given to differ-
ential diagnosis and treatment, and
the clinical features of skin disease are
thoroughly elucidated with suitable
illustrations. More practical knowl-
edge can be gained from a careful
perusal of this book than from a pro-
longed study of some more elaborate
works.
A Manual of Spboial Tbbatmbmt. By W. Watsoit
Ohbtkb, M. B.,F. B. O. S., F. R. S., Professor of
Snrjgery In King's College, London; Sorgeoii to King's
College HospltaJ. ete., and F. F Bubohabd, M. D. and
M. S. (Londl), F. B. 0. S., Teaeher of Practical Sur-
gery in King's College, London; Snrgeon to King's
College Hospital, etc. ; Complete work now ready. In
seven imperial octavo volumes, with illostrationa.
Volume Vll,595 oages, with 118 illastrations. Cloth.
90.75 net. Lea Brothers & Go.,' Philadelphia and
New York. 1003.
This volume of the above manual
of surgical treatment brings to com-
pletion one of the grandest works of
the age. The cordial reception, by
the medial profession, of the previous '
volumes clearly shows there is an
urgent demand for tho special informa-
tion that this work supplies. The
field of surgery has broadened to such
an extent that no teit-book of surgery
can do justice to the important sub-
ject of special treatment, and the
practitioner who is thoroughly ac-
quainted with pathology, symptom-
atology and diagnosis feels the want
of this kind of information in the diffi-
cult cases which he sometimes en-
counters. The authors of this work
have had an arduous task to perform,,
but a brilliant success has crowned
their laborious undertaking. It is
eminently a practical work embodying,
not all, but the best methods of treat-
ment* As the work is devoted ex-
clusively to surgical treatment, room
has been found for elaboration of
details in operative procedures and
after-treatment* This will be realized
better when we see the complete
work comprises about 3W)0 pages.
The present volume is devoted to the
treatment of the surgical affections of
the rectum, liver, pahcreas and spine,
the genito-urinary organs, the breast
and the thorax. No up-to-date practi-
tioner or surgeon can afford to be with-
out this work.
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IMPORTANT
FACTS
III
Pertaining To The Most Rational Treatment For INDIGESTION.
INGLUVIN
Not only Relieves the Symptoms, but Removes the Causoy by
Its Peculiar, Active, Bitter Principle.
IT
TONES UP THE STOMACH
INCREASES THE DIGESTIVE FERMENTS TO NORMAL
STIMULATES THE GASTRIC AND INTESTINAL MOTOR ACTIVITY
AS SISTS NATURE TO CARRY ON A NORMAL PHYSIOLOGICAL
DIGESTION
PILL INBLUVIN CCIIP- wbestive)
— A COMPRESSED PILU UNCOATED.
Combines all the excellent DIGESTIVE action of Ingluvin with
the additional therapeutic value of Nux Vomica, Aloin and GIngerln.
IT
INCREASES THE BLOOD SUPPLY OF THE GLANDS AND
MUCOSA OF THE STOMACH AND INTESTINES
PREVENTS CONSTIPATION AND ACTS AS A CARMINATIVE
INGLUVIN is indicated In all forms, including Nervous Dyspepsia,
whether in the acute, sub-acute or chronic stage.
IN8LUVIN IS A POSITIVE SPECIFIC FOR VOMiTINO IN OESTATION ANO THE
POST NAUSEA FROM ANESTHETICS, CALOMEL, ETC.
Prescribed in the same manner, dose and combination as Pepsin.
LinRATURf AND SAINPLE8 CHEERFULLY SENT ON REQUEST.
WHEN PRESCRIBING, SPECIFY WARNER A CO. AND AVOID SUBSTITUTES
WM. R. WARNER. & CO. ■™'"^"««™,
Philadelphia, New York, Chicago, New Orleans.
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228
Therapeutic Suggestions.
THERAPEUTIC SUGGESTIONS.
GoNOBBHiEAL Cystitis. — With the
ddoline of the acute and the onset of
the subacute or chronic stage, the use
of uriseptin will be of signal service in
most cases. It should be administered
in dessertspoonful doses with a teacup-
ful of hot water four times a day.
Injections into the bladder of warm
solutions of boric acid usually give
comfort to the patient.
An Intebesting Clinical Case. —
X, a white woman, twenty-two years
of age, was taken into the hospital on
account of syphilitic skin disease
(roseola papula) ; a blennorrhagic
vaginitis of most violent description,
with strong congestion of the mucous
membranes of the vagina. The latter
was of violent hue, somewhat brittle,
and yielded abundant secretion of a
greenish yellow pus, which showed
under bacteriological examination
abundant colonies typical of gonococ-
cas, diplococcus and other varieties of
bacteria. The gonococci infection
reached to the neck of the uterus,
whose tissues suffered from the same
degeneration as the vagina. Above
the mouth of the neck — from which a
greenish yellow and somewhat thick
pus oozed — was a syphilitic ulcer of
the size of a dime, clean at the bottom,
livid in color and rather deep.
Upon careful examination, the pa-
tient was found to be pregnant in the
third month, and, from the start, was
subjected to energetic treatment as a
serious case.
Under the treatment employed she
improved rather well ; but, though the
blennorrhagia was not cured, the syph-
ilitic manifestations of the skin disap-
peared, and the ulcer at the neck im-
proved somewhat until confinement,
which took place at the eighth month,
five months after her admission.
The confinement was normal. How-
ever, the patient was attacked by a
great flux, and suffered a complete
laceration of the right side of the neck,
an incomplete laceration of the left
side, an incomplete laceration of the
rear wall of the vagina, and a two-
thirds laceration of the perineum. The
placenta was removed at once ; ample
warm washes of a one per cent, solu-
tion of permanganate of potash were
appliea, and the uterus was stimulated
by massage, but remained inert. All
this was reported to me by the house
physician. I arrived at the hospital
four hours later, in company with the
well-known gynecologist. Dr. Mendez
Capote, who, upon having examined
the patient, decided to sew up the
lacerations. He washed out the vagina
and uterine cavity completely, adjusted
with the scissors the edges of the lac-
erated tissues, sewed up the wounds,
and touched the ulcer at the neck with
the cauterizer; then he gave another
wash and plugged with iodoform
gauze.
When the patient was on the operat-
ing table she had fever, 38.4° C. At
5 p. M. the fever was at 39""; then the
vaginal plug was taken out, and a great
intra-uterine wash of a one-half per
cent, solution of permanganate was
. applied very hot in a quantity of five
liters. The fever was at 40^ through-
out the night, and washes were given
every four hours.
The following day, at 8 a. m., tem-
perature 40°, same local treatment.
The fever lasted all day, falling to 39°
by the wash, but rose again to 40°.
The day thereafter, fever at 41°;
same treatment, with more vaginal
washes of bichloride of mercury be-
fore the uterine washes; the fever
keeps on at 41°.
On the next day, at 8 a. m. (tem-
perature 41.5°), I took out the stitches
made on the day of confinement,
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280
Therapeutic Suggestions.
washed well both uterus and vagina,
dried the latter with carbolated cotton,
and conveyed into the uterine cavity
eight grammes of pure hydrozone,
taking care that this liqai'd should flow
towards the vagina, into which I poured
•about 60 grammes of the same liquid,
tind drained the uterus with simple
gauze saturated in hydrozone, while
the vagina was drained by the same
means.
From that time on the fever declined
slowly, and at 6 p. m. it was apyretic.
The fever did not return, and the pa-
tient's cure proceeds without further
difficulty.
This case, which is interesting by
itself, proves of great value in setting
forth two points, viz. :
1. That, although the intrauterine
injections of pure hydrozone may be
dangerous, it can be applied if care is
taken to keep th« neck dilated as much
as possible.
2. That in this case the superiority
of hydrozone over the other treat-
ments of puerperal septicemia, in con-
nection with gonococcia, is indisput-
able; and that this splendid result
should encourage repetition of its ap-
plication. (The son of the patient
suffered from blennorrhagia in the
eyes. He was treated with one-fourth
per cent, solution of permanganate
and instillations of pure hydrozone
twice daily, alternating with cauteriza-
tions of forty per cent, solution of
nitrate of silver; and he kept liis
sight.) — Dr. Matias Duque, Director
of the San Antonio Hospital, Section
of Hygiene; abstract from the Revista
Medica Cubana^ April 15, 1903.
S Sprgs., N. Y.
Merz Capsule Co.,
Detroit, Mich.
Dear Sirs: — ^Your No. 17 comp.
santal is the best ever. Great results
in nocturnal emissions with it.
Send me another hundred, dollar en-
closed. Yours, C. H. G., M. D.
March 28, 1903.
Bromipin, according to Dr. Gareis,
is an excellent substitute for the alkali
bromides in epilepsy — it does not pro-
duce acne, is nutritious, and of great
efficacy. — Munch. Med. Woch.^ xxii.
No. 16.
Glyco-Thymoline for Erysipelas-
— Dr. Seneca D. Powell, of New York,
applies 95 per cent, carbolic acid in
erysipelas, and as soon as the skin
turns white he applies alcohol to check
the action.
The Dietetic and Hygienic Gazette
describes another treatment for ery-
sipelas. It is to cover the area and a
margin on the surrounding skin with a
thick layer of white vaseline, and cover
this with linen and a bandage to hold
it in place. Apply twice daily. Its
advantage over iodine applications is
the absence of pain and irritation.
In glyco-thymoline we have a remedy
for erysipelas which lacks the toxic
properties of carbolic acid and is far
more efficacious than white vaseline.
The following clinical history gives a
fair idea of its action :
Jno. Citatatto, M. D., of "New
Orleans, writes: '*A young lady sent
for me and upon my arrival I found
her suffering from an attack of erysip-
elas. I decided to try glyco-thy mo-
line, and accordingly made a solution
consisting of four ounces of glyco-
thymoline to two pints of water and
ordered the patient's face to be kept
constantly covered with compresses
saturated with this solution. With the
very first application the itching ceased
instantly. The swelling of the face
disappeared very rapidly and after
three days of this treatment my pa-
tient was entirely cured.''
Treatment of Eczema or the
Scalp. — ^Parker pleads for more pa-
tience and perseverance in the treat-
ment of this troublesome affection. So
many physicians prescribe time or
pronounce the condition hopeless that
parents often discredit the physician
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.ANASARCIN
# (Oxydendroii-Sambucu8-5cilla Compound.)
\ A SPECIFIC FOR DROPSIES
t
i
\
Doctor:—
If you know a thing to be a fact, it is not wrong or
unethical to say so. Neither does it smack of quackery or
Charlatanism and should not shock the sensibilities of any,
however refined, cultured or zealous of medical ethics for us
to claim that ANASARCIN is a specific in dropsies, when
clinical experience has demonstrated such to be a fact. If
quinine ia a specific in malaria, much more is ANASARCIN
in dropsies resulting from disease of the heart, liver or
kidneys, because that a trial of it in hundreds, yea, thousands
of cases has not resulted in a failure known to us where
directions have been followed.
Besides being a specific for dropsies, it is a permanent
cure in the conditions mentioned when begun early and
continued a sufficient length of time, i, e.^ until the diseased
organs regain normal function. ANASARCIN is composed of
the active principles of Ozydendron Arboreum, Sambucus and
Urginea Scilla, and is sold exclusively to physicians or
druggists for physicians. Trial box free with literature and
testimonials furnished physicians on application.
WINCHESTER, TENN., U. 5, A.
\
\
ADDRESS — - ^
\ The Anasarcin Chemical Company ^
1^ — LONDON AQENTS — |^
# Tbos. CtrlMty 6t Co., 4'I0-I2 Old Swmn Lmae, Upper Tbmmes St, B. C.
t ?
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INDEX,
who promises recovery within a rea-
sonable time. The first measure in
successful treatment is a thorough
washing and shaving of the head. Cas-
tile soap and much water of a temper-
ature not less than 100"* F. should be
used. The same water should not touch
the head twice, and pledgets of absorb-
ent cotton are to be used to remove the
crusts. When cleansed the head should
be dried with a clean, soft towel. Dur-
ing treatment the pillow-case should be
consigned to the wash-tub each morn-
ing and a clean one put into its place.
These are not over-particular but im-
perative details if favorable results are
desired. Jugglery in prescriptions
cannot avali, and rigid hygienic meas-
ures, extending to all the surround-
ings, must accompany medical treat-
ment. The second step is in the case
of nursinff infants, to treat the mor-
bid constitutional condition generally
found in the mother. The alterative
iodia is nearly always applicable, and in
severe cases should be administered
to both mother and child. If the irri-
tability attending the eruption requires
special treatment, bromidia should be
given. Some children will require an
easily assimilated iron tonic. The bow-
els must be kept open with a mild
aperient, given in the early morning.
Locally, boroglyceride is the best oint-
ment. Ecthol is also a remedy of much
value, being a powerful corrector of
depraved conditions in fluids and tis-
sues. It is employed diluted, accord-
ing to the severity of the case, and
sprinkled upon a thin cap of surgeon's
cotton. The cap should be renewed
and the old one burned dailv.
Hat-Fever. — There are many theo-
ries regarding the causation of hay-
fever, including uric acid or other de-
praved state of the system, micro-
organisms in the air, and pollen
from plants. Whatever theory is
adopted and a systemic treatment
undertaken to correspond with it, it
has been found that intelligent local
treatment is productive of great bene-
fit.
For this purpose a thorough wash-
ing or douching of the nasal passages
with a weak hot solution of Tyree's
antiseptic powder has been found very
beneficial. It cleanses the membrane
of poisonous secretions, soothes its
irritability, and tones it up and
strengthens it to resist further invas-
ion. By frequent repetition as soon
as any feeling of discomfort begins to
return, the attack can be greatly
shortened, and the patient made com
paratively comfortable throughout its
duration.
Mississippi Valley Medical Asso-
ciation AT Memphis, Tennessee, Oc-
tobeb 7-9, 1903. — One and one-third
fare on certificate plan for the round
trip. Trains leave St. Louis 7:20
A. M., 1:30 noon, and 10:15 p. m. ;
leave Memphis 7 :20 p. m., 10:55 p. m.,
and 8:20 a. m. Through sleeping
cars, dining car, and buffet library
smoking car. For full particulars
write to C. C. McCarty, D. P. A., or
T. F. Bowes, C. P. and T. A., St.
Louis, Missouri — Illinois Central Rail-
road.
INDEX.
OBIQINAIi ABTICLBS PAGE.
Dermstologtcal Teaching in Madrid. By A. Ravogli,
M. D.. orncinnatl, Ohro 187
Hydrocele— Its Cure by a Simple Operatioa. By B.
F. Lioorieh* M. D., Barbados, West Indies . . 190
Prostitution in Japan. By Solomon Claiborne
Martin, Jr., M. D., St. Louis 190
A Plain Talk on Matters Pertaining to Genito-Uri-
nary Anatomy, Physiology and Diseases. By Dr.
Bransford Lewis, St. Louis 201
Obiqinal Abtiolbs. paok.
Bacteria as an Etiologic Factor in Skin and O«nito>
Urinary Diseases. By Dr. Gottfried Trmntmann.
Munich, Germany 2IO
The Technique of Prostatectomy. By Nicholas
Senn, M. D., Chicago, Dlinois 218
SlLBOTIONB 220
New Publioatioms 224
TUKBAPKUTIC SuOGKSnONS 228
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MCDIClNr
A BI-MONTHLY MAGAZINE DEVOTED TO THE CONSIDERATION OF CUTANEOU8
VENEREAL DI8EASE8 AND QENITO-URINARY 8URQERY.
EDITORS
S. C. MARTIN, M. D. G. M. PHILLIPS. M. 0.
mtOTEMOR or OENMATOLOOV IN THE BAIINCS MCOIOAL OOLLEOC PNOrCMOR Or OCNrrO-URINARY OISCAMS ST. LOUIS OOLLEM OP
PMVSIOIANS AND SUHOCONS.
MANAGING EDITOR
S. C. MARTIN. Jr.. M. 0.
•T. LOUIS.
SUBSCRIPTIONS AND ADVERTISING.
The subscription price of this Joamal is |1.00 per year, in advance, postage prepaid, for the United States, Canada*
and Mexico; |1 50 per yeai- for all foreigrn countries included in the postal union. Single copies, 25 cents.
Advertising rates will be furnished upon application.
Address all communications, correspondence, books, matter regarding advertising, and make all checks, drafts-
and post-office orders payable to
AMERICAN JOURNAL OF DERMATOLOGY,
Fidelity Building, St. Louis, Mo., U. S. A.
Vol,. VII.
NOVEMBER. 1903.
No. 6.
THE NEW UQHT CURB.
Bt Cobydon Euosni Rookbs, M. D., Seattle. Wash.
The therapeutic qualities of light
have been recognized and utilized — in
an indifferent way — for so long a time
that it is impossible to fix the date of
the origin of the practice. The sun
bath was probably employed during the
period of sun-worship, and at a remote
period the substitution of artificial
light became a common practice.
Among the people of portions of Asia
we find their midwives treated post-
partum inflammations by placing their
patients before blazing fires. The ab-
domen was uncovered and the woman
placed before the fire and forced to re-
main — regardless of her outcries — until
in some instances the skin was blist-
ered. Rheumatism was treated in the
same manner.
In many countries the sun bath is
still a common method of treating va-
rious forms of disease, especially rheu-
matism and diseases of the chest. My
attention was first drawn to the action
of light by seeing Indians in the tropics
applying light in this way. But it re-
mained for Dr. Finsen to finally solve
the problem of the practical applica-
tion of light. Though his methods
were crude and his theories incorrect,,
nevertheless he opened the way to util-
izing this agent which is destined to-
revolutionize the practice of medicine.
It is even now forcing us to abandon
many pet theories and disregard much
which the colleges and text-books have
long taught us as proved facts.
Dr. Finsen's apparatus appears to-
have been designed for the treatment
of lupus only, since the small area of
light and the great length of time re-
quired for exposure would make it im-
practicable in the treatment of skin
diseases covering large areas, such as
we sometimes find in eczema.
The doctor supposed he was destroy-
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284
Original Articles.
ing the germs of lupus by chemical ac-
tion. Certain of the high vibratory
forces sometimes called actinic rays
have for a long time been improperly
designated as chemical rays, and the
belief is so thoroughly established that
these have some peculiar -chemical ac-
tion which is essential to the destruc-
tion of pathogenic germs, that it is a
difficult matter to discuss the action of
light with most physicians. The fol-
lowing is no more unreasonable than
most of the so-called scientific experi-
ments. In the Scientific American for
June 20, 1903, page 473, Dr. J. W.
Kime has an illustrated article upon
light, in which he details the printing
of photographs from negatives inclosed
in the human mouth. Here ia * 'Ex-
periment No^ 3— Penetrability of ac-
tinic light." Then he tells us that **In
these experiments the ttegatives were
placed on the side exposed to the sun."
In trying to prove the * 'Penetrability
of actinie light" h% uses the combined
rays in his experiments. In turning
the face to the sunlight he used the
combined force of the sun's rays — the
very power for which I have been so
long contending. Such men are not
very close observeirs. These mistaken
are very largely due to the universal
spirit of error r^ardtng the action of
actinic rays. The doctor is no excep-
tion to the rule. Let it be understood
that light has no specific chemical ac-
tion ; that the chemical action depends
upon the surface upon which the rays
strike and not upon any chemical qual-
ity in the rays themeelves, and we shall
be better prepared to comjw^hend the
law governing its therapeutic effeets.
My investigations have been con-
ducted wholly independently of Dr.
Finsen's, for I soon became convinced
that the violet rays were incapable of
penetrating the tissaes, and therefore
greatly inferior to my ideal of the
power I sought. I abandoned all ex-
periments with the violet rays after
reaching this conclusion and turned my
attention to the combined rays of the
arc light, and of the incandescent lamp.
I soon discovered that these were far
superior as pain relievers to any agent
with which I was acquainted. Still
this was all unsatisfactory, for as yet I
had been unable to discover the law
governing their operation and was
therefore applying them empirically.
By changing the power of these lights
I found that the results were very dif-
ferent, and in this way I worked out
what I believe to be the law governing
the therapeutic action of light.
With almost any light I found I covAd
favorably modify most forms of skin
diseases, but it was a long time before
I could cure them.
I soon abandoned the use of the arc
light, a^ I found it wanting in many
features which I believed to be essen-
tial to the degree of success I desired
9nd believed possible of attainment.
I believed we were dealing with a
force which would be far reaching in
its results if we eoald dtscover the law
governing its action so as to eiiiploy it
intelligently. This I sought, rather
than the curing of certain diseases by
the empirical application of a power
which mi^t be capable of great pos-
sibilities. It was positively known that
light is capable of destroying patho-
genic germe when they are located upon
tiie surface. Reasoning, a priori^ it
would destroy them in any position if
sufficient force were brought to bear
upon them. For this purpose I con-
centrated the rays from a 300 c. p. in-
candescent lamp so as to obtain the
highest power without bringing them
to a focal point. Thie has proved the
most satisfactory light with which I
have operated.
I believe our operations may be gov-
erned by the following law, viz. : J%e
fferm-de^troying power of light is equal
to the sum of the vibratory forces em^
ployed. Now let us say that this gema-
destroying power depends solely upoi^
the vibratory forces, and we shall have
reached a point from which investig»-
tions may be pursued iatelligently.
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The New Light Cure— Rogers.
aaa
If these rays are applied to a severe
ease of eczema in which the diseased
surface is extensive and the skin infil-
trated, thickened add excoriated from
scratching, the first noticeable efEectJs
the almost immediate relief from itch-
ing. The relief will continue for an
iDdefimte period and as soon as the
itching returns the light should again
be applied. In severe cases two treatr
ments dailj for a few days will speedily
effect a cure. If but one treatment
daily can be given the patie»t should
be inatructed to bathe the parts with a
mixture of carbolic acid and water
whenever the itching returns. The
mixture should be strong enough to
occasion some smarting, and in a few
minutes after application the parts
should be carefully dried and dusted
with talcum or other harmless powder
to prevent chafing. The light acts
equally well upon all forms of the dis-
ease* Improvement often occurs with
surprising rapidity. Cases which have
for yeurs resisted every form of treat-
ment will sometimes present remark-
able changes in a few hours. If prop-
erly conducted one operation will con-
vince aayone of the value of light in
the treatment of eczema. It is just as
satisfactory in the treatment of most
skin diseases, including the tubercular.
If these rays be applied to carbuncle
dixring the early period of develop-
ment it will be aborted. In a few min-
utes the pais and soreness will be en-
tirely relieved or greatly modified. In
severe cases, well • advanced, where
there is great constitutional disturb-
ances, light also relieves the pain and
soreness, reduces the fever and at once
inaugurates a more favorable condition
No agent at our command bo quickly
and certainly modifies the condition of
indolent ulcers, whether syphilitic,
tubercular, varicose or those resulting
from other forms of blood poisoning.
To this we m^bt add all forms of ex-
crescences, such as warts, moles, ex-^
uberant granulations, etc.
Lupuaalso may be included in the
foregoing list. If the destruction of
tissue has not been great it can be
cured by dne treatment of fifteen or
twenty minutes' duration. In no case
have I found it necessary to resort to
local anesthesia to prevent suffering;
but the parts subjected to the rays
should be thoroughly cocained. A
strong solution, about 15 per cent, or
20 per cent., is preferable. The neigh-
boring parts should be protected by a
number of moistened layers of sheet
asbestos with openings the size of the
uker. All scaly forms of skin dis-
eases, if severe, should be treated in this
way.
Epithelioma is just as certainly cura-
ble as lupus, but the mode of operat-
ing is somewhat different. In most
cases the patient should be brought
under the influence of anesthetics and
the diseased tissues thoroughly de-
stroyed by the actual cautery. In a
few days the separation will occur, after
which the parts should be cocained and
the light applied as for lupus. If,
however, we are fortunate enough to
see the case early, the cauterizing may
be omitted. In an ordinary case, un-
less forewarned, few operators will
cauterize sufficiently the first time.
From unfortunate experiences I have
learned this lesson. Cauterize until
you think it i^ enough ; continue until
you think you are quite sure ; then cour
tinue until you think you have done
too much ; after that stage is reached
continue as much longer as you dare,
and it may be enough. You will save
yourself much time and your patient
much suffering by cauterizing thor-
oughly the first time.- Be sure that
the germ infiltrated tissues are thor-
oughly destroyed. The actual cautery
is used in these cases to expedite the
destruction of such tissues, as it can
be done more quickly, and I greatly
prefer it to the knife, caustics or the
high power of light. But in all cases
the resulting ulcer should be, treated
by light to make sure that all germs
have been destroyed.
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Original Articles
If all the indurated tissue is not de-
stroyed by the first operation it will
usually be better to apply the cautery
a second time and follow with the light
as before mentioned. After the slough-
ing following the use of the cautery
the disease will return if left to itself ;
but I have found that if light is prop-
erly applied the cure will be complete.
I have a number of cases who have
been cured more than two years in
which the disease has shown no dis-
position to return. It may fairly be
said that this is a safe and certain cure
unless the disease is far advanced or
located in some unusually inaccessible
place. Of course the technique in
these operations counts for something,
but that is readily acquired. After
one successful case the operator ac-
quires confidence in himself and the
agent he is employing, which of itself
will add much to his skill. The ^rst
application of light, after cauterizing,
will relieve the pain and soreness in a
great degree.
SYPHILIS INSONTIUM.
Bt Ohablbs E. Caldwell, M. D., Oiaeiimatl. Ohio.
In reporting the two cases of extra-
genital syphilis which I have observed
in my own practice in the last seven-
teen years, there seems to be no valid
excuse for entering into a long disqui-
sition upon the history, etiology j pa-
thologv or treatment of syphilis.
Syphilis insontium differs only from
syphilis ordinarily acquired, in its
extra-genital location, in the igno-
rance of its victim of the possible
source and nature of the malady, and
the somewhat greater difficulty of dif-
ferential diagnosis to those not thor-
oughly familiarized by frequent op-
portunities of observation with the
appearance of the Hunterian chancre.
During some ten years' conduct of a
surgical and venereal clinic at the Mi-
ami Medical College, where I was ac-
customed to treat many cases of syph-
ilis, I never encountered a case where
the extra-genital origin could be more
than suspected.
Both of my cases occurred in pri-
vate practice ; both of them were in
young, unmarried women of correct
deportment, and both of these young
women consulted me for what they
had considered trivial sores on the lips,
which had excited their apprehension
by reason of their unusual duration,
gradually increasing size and conse-
quent disfigurement.
Moreover, both of them presented
themselves during the same winter.
In neither one was there the slight-
est room for doubt in the diagnosis on
first inspection, diagnoses subsequently
confirmed by the appearance of sec-
ondary eruption, glandular induration
and other indubitable signs of syphilis.
There seems to be an opinion preva-
lent among the laity, and among a
great many physicians, that extra-gen-
ital syphilis is apt to be of a more in-
veterate type than that less innocently
acquired. If there were anything to
support such a contention, and I have
never found any evidence for such, it
would probably be owing to late recog-
nition of the nature of the initial
lesion, or failure to recognize it until
secondary constitutional syphilis de-
veloped.
In the two cases coming under my
observation, while the constitutional
symptoms were unmistakable, the sub-
sequent course of the disease was free
from any unusual complications, and
the recovery was complete, one case
remaining free from sequelae three
years after treatment, and the other
five years, having in the meantime
married and become the mother of an
apparently healthy child.
Case I. — N. F. presented herself at
my office with what she called cold
sore on the lip, but she said it was un-
like any cold sore that she had had-be-
fore as it was much larger and harder.
I suspected the nature of the lesion at
a glance, but on closer examination^
the marked cartilaginous induration,.
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Syphilis I nsontium— Caldwell,
287
and the age of the patient, eighteen,
the involvement of the submaxillary
lymphatics, strengthened me in my
opinion^ I questioned her carefully as
to whether she were the object of at-
tention from any young man, and she
such as she had admitted.. The truth
of his statement was subsequently cor-
roborated by a physical examination
of the girl, whom I sent to a private
hospital for treatment. During her
stay at the hospital she developed a
Syphilis Insontinm— Lip Chancre— Collection of Charles E. Caldwell, M. D. Case No. I.
confessed that she was engaged to a
young man. Reproved to be a soldier,
and upon confronting him with the
'facts in the case and examining his
mouth, I found that he had well-de-
veloped mucous patches. He denied
any further intimacy with the girl than
marked syphilitic roseola, some noc-
turnal headaches and tibial and sternal
tenderness. She remained under ob-
servation about one year. Three years
afterward I saw her and she said she
had hadno recurrence of symptoms,and
from her general appearance, I had no
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288
Original Articles.
opportunity to examine her earefnlly,
I should have thought her to be in the
best of health.
Case II. — M. W., age twenty-two,
well-developed young woman, who in
the years of development from twelve
to fifteen had been under my care for
epilepsy, and who had subsequently on
the regular establishment of the men-
strual function recovered entirely from
her epileptic attacks, presented herself
at my office in December, '98.
She complained of a sore on her lip
which she had considered a cold sore
or fever blister, but it had grown worse
for the past three weeks.
The character of this sore was also
unmistakable, the braH^ infiltration
of the lip and characteristi# gcistly
feel of the sore, with some soreness irf
the throat and enlargement of the sub-
maxillary glands, made me certain of
the diagnosis.
I questioned her with regard to her
relations with young men, and she ad-
mitted that a young man whose busi-
ness, as she said, was following the
races was her fiance, that her parents
did not altogether approve of him, but
that she had always found him gentle-
manly and respectful.
I asked to have the young man call
at my office. He was away at the time
but within a week put in an appear-
ance. I questioned him^ found a his-
tory of(syphilis, and there were present
several large mucous patches on the
tongue and the pillars of the fauces. I
told him that he had infected the girl,
and that in view of thedanger to others,
and the advisability of impressing her
with the need of regular medical su-
pervision, I should have to acquaint
her with the nature of her trouble.
This I did in a general way without
going into unnecessary detail. Three
weeks later she developed a marked
roseola with other symptoms of the
disease. I examined the genitals care-
fully for a lesion, but the girl was evi-
dently a virgiti. She had a leucor-
rhea and subsequently developed mu-
cous patches at the posterior commia*
sure of the vulva. She was under ob-
servation and treatment for a year and
a half. She then ceased to be a pa-
tient of mine, having moved into a re-
mote suburb. She has since married
and is the mother of a child to all
appearances healthy, although it will
be interesting to see how it seems at
the time of second dentition.
Case III. — This case I add to the
others as one of doubtful nature as far
as the extra-genital infection is con-
cerned. It is briefly as follows: A
young man, age twenty-one, had been
under my care for a period of three
years for" syphilis.
His case had never been a severe
one. He had had few secondary man-
ifestations, but the most troublesome
sjrmptom was the recurrence of mucous
patches in the mouth and throat. He
was an habttual smoker, and in spite of
remonstrances on* my part he would
continue to smoke excessively. The
result was that he would occasionally
come back with a fresh mucous patch.
Otherwise, he seemed perfectly well.
Three years from the date of his chan-
cre, he having been a year free from
auy manifestations whatever, he an-
nounced his intention to marry. I ad-
vised him strongly to defer the wed-
ding for another year. Much to my
surprise the announcement of the wed-
ding occurred shortly after. Within
six weeks he appeared in my office
with his wife infected with a syphilitic
pharyngitis. It was unmistakable.
There was no evidence of chancre either
genitally or extra-genitally. Where
was the woman's lesion? I do not
know. All I do know is that she had
an obstinate case of syphilis.
She has since given birth to a child.
As yet there are no manifestaUooa,
but there is yet time for them ^mfh
pear.
I have reported these closes beeauaa
I believe it is well for sudi -cases te he
put on record. The pnblicati^Q of idl
such oases will make the profeseioii
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Diagnostic Features of small- Pox- melv in.
9mo
more alert to recognize what if unrec-
<>gDized must prove the most insidious
source of the wide-spread dissemina-
tiofi of a disease which attacks the in-
nocent as well as the guilty and spreads
contamination in many pure homes.
i0lAQNOSTiC FBATURBS OFSMALL-POX.
Bt Gsobgx 6. Mklvin, M. D..
DanikAlologUt to Home for^IneiurablM, Ete., Bt. John,
N. B. ^
To dtseuss the question of the diag-
nosis of small-pox, that is to say, of
genuine virulent, unmodified variola,
would be like announcing that ^^the
Dutch have taken Holland;" it would
be going over something that has been
definitely settled in the profession for
two hundred years. Indeed, a blind,
deaf-mute could diagnose a straight-
'forward case of small-pox. All he
need do would be to use his finger-
tips; the far-famed **shotty" condi-
tion would tell him the whole story.
But since the introduction and almost
universal application of vaccination,
small-pox has ceased, clinically, to be
the disease it once was. It is no long-
er the most easily recognized of all
disorders. So pronounced has this
become, that an entirely new name is
required to describe this condition, and
in our {tactical acquaintance with it,
probably three-fourths of the cases
seen deserve the term varioloid instead
of variola* And even this is not all.
Varioloid is a modifieation stretching
between wide extremes ; from a condi-
tion hut little removed from the classi-
cal disease to a state very little differ-
ent - from the normal condition of
health. Yet, as every one knows,
tliis apparently trivial phase of the dis-
ease is just as dangerous, so far as con-
tagion and reproduction are concerned,
aa the most violent instances of the
hmnerrhagie or ^^black" type.
In ovder, then, to approach the sub-
Jeet in a practical and judicious man-
matf several separate ideas mnst be
moted a^d iHscumed. First among
them is to definitely determine the
class of disease in which it is proper
to place small-pox ; second, the diseases
which most resemble it; and third, and
by no means least important, the quan-
tity and quality of knowledge requisite
inlthe examiner to properly recognize
and classify it. To those three head-
ings, then, I will address myself, in as
brief but as dear a manner as pos-
sible.
1. The principle of evolution, so
strikingly promulgated in the middle
of the preceding centurv by the pro-
found and almost divine genius of
Darwin, leaves it ecarcely a matter of
doubt but that mankind at first was af-
fected by only a few, possibly only one,
primordial disease. What that disease
was, is, of course, far beyond the
power of any one to say, or even to
speculate upon, with anything like
probability. The universal law of evo-
lution, acting in this, as in every other
department of nature, gradually differ-
entiated the kinds and multiplied the
number of those diseases. Even today
we can trace, dimly indeed, yet clearly
enough for our purpose, collateral lines .
between many of our most important
disorders. For example: those dis-
eases attacking the lower iutestinal
tract, as ordinary diarrhoea, cholera
morbus, typhoid fever, typhus fever,
yellow fever and Asiatic cholera, are
all, to my mind, undoubtedly descended
in successive or parallel lines from one
ancient type. They are all germ-pro-
duced, and that fact alone serves to
solve the riddle of their causation and
connection . If one species of pigeon has
given rise to scores of varietiesi all dif-
fering in appearance, manners, and
favorite location : if one species of rose
has, in like manner, evolved into a hun-
dred, it does not require a very great
stretch of the imagini^on to eonceive
of one species . of germ being similarly
evolved into a dozen or so, collateral,
and yet distinct types, each having its
owQ UMa^dlod of prapagation, its own
favorite location, and its own method
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of manifesting its effects upon the hu-
man economy. A similar parallel
could be drawn between a dozen or so
diseases affecting the respiratory or-
gans, and above all, because so appar-
ent to the eye and touch, we see a very
great number of diseases of the skin
undoubtedly arising or descending from
one primeval progenitor. All of us,
with a taste for history, know perfectly
well that even within historic times, a
space of not, at the outside, more than
3000 years, many of those diseases
were regarded as identical. It is no
answer to reply that it was merely the
result of ignorance. To differentiate
many of these disorders does not re-
quire a profound knowledge of medi-
cine in all its branches. What com-
monly intelligent man, accustomed to
meet with disease, could confound a
typical case of measles with a like case
of scarlet fever? Yet no such distinc-
tion was known to the ancients. Were
they, then, not only ignorant, but also
stupid? We know the contrary. No
more brilliant minds existed than those
of some two thousand years ago, among
the Grecian philosophers and physi-
cians. We are, therefore, forced to
the inevitable conclusion that at that
time, and for long afterwards, there
were not the well-established boundary
lines between many of the allied dis-
eases that there are at present. As
time went by, those germs showed
more and more predilection for partic-
ular parts of the human body. I have
elsewhere* discussed the remarkable
favoritism of the tubercle bacillus for
localized situations, this peculiarity be-
ing so pronounced that it is becoming
more than probable that, even in this
one species of micro-organism, there
are several distinct varieties . The cele-
brated distinction recognised by .Koch
between the human and bovine varie-
ties, brings additional force to this
*Vide article, by author, ** Report of One
Hundred and Fifty Cases of Skin Disease,"
in the American Journal of Der^natology ^
March, 1901.
hypothesis. This fairly well-dejGned
law of segregation among germs led,
early in the history of disease, to the
classification of the so-called **local**
diseases . It was not without difficulty,
however, that this term, with its un-
derlying idea, came to be incorporated
into medical science. Indeed, there
are not wanting yet, many authorities
of very reputable standing that deny
that there is, properly speaking, any
such thing as a ''local" disease. It is
not my intention to enter upon this
controversy; we all know the ''pros
and cons" of it already, and, also, that
if strictly in theory there be no such
thing as a disease attacking one organ
of the body to the utter exclusion of
all others, yet in practice it is so, and
that scarcely anything in the way of
classification has done more for the
advancement and convenience of medi-
cine than this principle. But small-
pox, for long was denied a place in this
category, and I am not at all sure that
there is any great degree of unanimity
yet, upon the subject. But, I most
humbly submit, until such acknowl-
edgment has been made, and small-
pox be clearly recognized as, purely
and simply, so far as any disease can
be restricted to one organ, a disease of
the skin, no great progress can be at-
tained in its prevention and treatment,
and doubt and disturbance will con-
tinue to dog the path of the observer
concerned in its detection and recogni-
tion. • Here, permit me to say again,
that I am quite aware that such a
statement will not be accepted by,
perhaps, a majority of those interested
in the subject, but for that I am not
responsible. It is not very long ago
that I heard an old and very much
respected member of the profession
declare that th^ most important symp-
tom in small-pox was the pain in the
back ! That, in a nut-shell, illustrates
the standpoint — the erroneous .stand-
point, I respectfully contend, from
which it is viewed by a great number
of our physicians, even yet. The
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Diagnostic Features of Small- Pox— Melvin.
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truth, howerer, is slowly making its
way. It is well known, although I
have spoken of variola as a germ-
produced disease, that its specific cause
has not yet bet been isolated. Re-
cently, however, Dr. Councilman, in
a * 'Preliminary Communication on the
Etiology of Small-pox," announces
that he has succeeded in isolating a
germ that apparently satisfies all con-
ditions necessary to be the true causa-
tive factor in this disease. Though
not specially germain to our subject,
it may be stated that, unlike the ma-
jority of important pathological germs
heretofore discovered, it belongs, not
to the vegetable, but to the animal
kingdom. In other words, it may be
classed with the protozoa, and in this
respect is akin to the famous and re-
cently differentiated cause of malaria.
I regret very much ray inability to
have had access to the original mono-
graph, but I quote from an apparently
trustworthy review of it. He enters,
at considerable length, upon the life-
history and mode of operation of the
germ in the human economy ; but the
point to which I wish especially to
give emphasis is his description of the
final action of the germ just previous
to the beginnings of the clinical mani-
festations of the disease in the human
subject. It is first necessary to say
that he believes the germ to be the
common causative factor in variola
and cow-pox, or vaccinia. I quote:
*'The whole process, as now known,
takes place in the lower layers of the
skin, where the germ penetrates the
epithelial cells and takes up its cycle
of development. In cow-pox it is
chiefly amoeboid in character, and does
not involve the nucleus of the skin-
cell. In small-pox, on the other hand,
it grows and there enters the nucleus
of the skin-cell, where it undergoes an
apparently sexual generation, ending
in the breaking down of the nucleus,
the disperson of the spores, and the
setting up of the fever which consti-
tutes the seizure of the disease, and
the pustules which follow closely upon
it." He does not claim thatitalon^
is concerned in the whole of the pus
formation, as, undoubtedly, the well-
known pus bacteria here play also a
part. **It is, however," he says, **the
efficient and main cause." The reason
I have given this point such attention
is, I think, clear. Nothing could more
lucidly point out the purely dermal
and local character of the disease*
Just so surely as the germ of typhoid
has an extreme predilection for Peyer's
patches in the intestines, so surely
does the germ of small-pox pick out
the skin to pursue its life-course.* If
more proof of the cutaneous nature of
the disease were wanting, it would be
seen in the remarkable success ob-
tained in the treatment of the disease
by enveloping the patient in blue light.
Recent experiments have proved that
this procedure cuts short the fever,
aborts the pustules and entirely prcr
vents pitting. Having then, I think,
shown that the disease is essentially a
skin one, a very great step forward
has been taken as to its diagnosis. To
an audience of general practitioners it
is, perhaps, necessary to say that skin
diseases depend almost wholly on ob-
jective symptoms, or, as Flint very
properly called them, signs, for their
diagnosis. In fact, this should be
true of nearly all diseases. We con-
stantly place far too much stress on
the subjective symptoms: upon what
*Since writing the above I have noted the
following, which further demonstrates the
peculiar affinity of pathological germs for
particnlar locations in the system:
Proliferation in Micro- Parastic Infections: —
'*In the case of the so-called toxin bodies,
their selective activity on certain tissues and
cells is well known — for example, the tetanus
toxin, which acts selectively on the cells of
the central nervous system. In the same
way, certain micro-parasites exert this repro-
duction reaction specifically — for exami>le,
the coccidium oviforme excites proliferation
on the epithelial cells of the bile ducts; the
infective agent of syphilis excites prolifera-
tion on the connective tissue cells.**— Keith
W. Monsarrat,!M. B., F. R. S. C. Edin., in
•'Etiology of New Growths." (^Brit, Med^
Jour,,^viM 27,1908.)
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ourptlients tell us. They may deceive
II8» oonscioasly or unconsciously, but
we<Nin, or ought to be able to, depend
mpon what we can see, hear and feel.
Therefore, I reiterate, when coming to
a suspected small-pox case, we should
firmly and unswervingly cast aside all
ideas relative to the patient's story
and look upon the true seat of the dis-
ease — the skin — with unbiased and
unprejudiced eyes. Should the case
be small-pox, modified or unmodified,
what shall we see or feel? I reply, in
every instance, papules, in some phase
of their development and situation,
either under the horny layer, upon a
level with it, or raised above it, and
either true papules, vesicles or pus-
tules. I make no mention of number.
This may vary from, possibly, one or
half a dozen to very many hundreds.
But, unless there be papules, or their
successors, I hold there can be no
diagnosis of small-pox. We have here
a local irritant, the suspected causa-
tive germ. Irritation, everywhere,
causes inflammation, which is nothing
more or less than a temporary in-
creased flow of blood to the irritated
part. This increased blood supply
lays down or builds up an abnormal
tissue, abnormal both in kind and de-
gree. This tissue is a tumor — this
tumor is the papule. The causative
factor of cancer, whatever it may be,
is likewise an irritant, a precursor of
local inflammation — a builder-up of
abnormal or debased tissue : the pro-
cedure is the same, or very similar, in
both cases, one being acute, the other
chronic. In the small-pox instance,
this occurs in the cutis vera^ and ac-
cording to a natural law — the law of
least resistance — the papule becomes a
veritable eruption ; it erupts or breaks
through the thin physiological cover-
ing above. The true disease resides
in and about these papules; indeed,
for the purpose of argument we need
only concern ourselves with one single
papule. The mere multiplication of
them does not alter the principle of
the disease, although it does affect its
gravity. Just as cancerous tissue,
breaking down, and in direct propor-
tion to its size and situation affects the
entire life functions of the body, so
small-pox papules, almost, at times,
infinite in number, and rapidly chang-
ing into absorbable pathological prod-
ucts, affect, in a profound manner,
the general constitutional processes;
hence, the fever, pain, vomiting, etc.,
etc. Flint, the very best of all Eng-
lish medical writers, so far as elegance
and accuracy of language go, in de-
scribing the clinical history of the dis-
ease, says that the amount and viru-
lence of the eruption depend upon the
acuteness and gravity of the constitu-
tional symptoms, as fever, reduced
action of the heart, etc. In the light
of advanced knowledge the very re-
verse is true. The constitutional symp-
toms arise from the the skin-lesions,
and not vice versa. We have all heard
of variola sine eruptione^ but few of
us, I think, have seen it; nor do I
think it will ever be seen again. It is,
I have not the smallest hesitation in
saying, a figment of the imagination.
All such cases have been observed, or
supposedly observed, in epidemics of
the disease, when the reputation of
some gentleman was at stake in the
matter of prognostic diagnosis, if I
might coin a phrase. This, or lack of
accurate knowledge concerning the
pathology of the disease, amply acr
counts, in my mind, for all such anom-
alous instances. The case for the
appearance of ghosts is a thousand
times stronger than is the case for
small-pox without eruption. Yet few
of us have had the pleasure of meet-
ing the former.
The relative importance of the con-
stitutional symptoms are not denied;
but in view of the fact that in nearly
every case of di£Scult diagnosis in
small-pox they are nearly always either
absent or very slight, and that each
and all of them may be present in any
one of a dozen or more diseases, re-
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Diagnostic Features of Small- Pox—Melv in.
248
sembling to a greater or less degree
variola itself , I claim that in obscure
cases (and these are the only ones with
which we are concerned) almost ex-
clusive attention should be centered
upon the eruption. Enough has al-
ready been said as to the character of
this eruption. It is papular, not macu-
lar; progressively and invariably
changeable, not stationary ; and is alto-
gether dependent upon the localized
causes, and not upon the constitutional
symptoms, the later being, in truth,
only symptoms.
Having dwelt, perhaps, inordinately
long upon this heading, let me hurry
on to briefly me&tion some diseases
with which small-pox may be con-
founded. I say **may be confounded,*'
not the reverse, for the ^eat danger
in any epidemic of the disease is not
that it should go unrecognized, . but
that ordinary and generally harmless
cutaneous eruptions may be taken for
it, to the inexpressible detriment and
danger of the unfortunate individual
subject to them. For, undoubtedly,
when public excitement is aroused and
fear is at fever heat, it does not require
any great amount of courage to pro-
nounce a suspected case one of small-
pox. Where courage and knowledge
are required is when one pronounces
such a case not one of the suspected
disease.
2. I will not attempt an exhaustive
list of variola-like diseases. As is
more practical, I will give a few illus-
trative incidents, occurring in my own
practice, during the epidemic of 1901-
1902, in this city. (1) At the request
of a prominent general practitioner,
who, by telephone, informed me that
he strongly suspected small-pox, I ex-
amined Mrs. . Found the fore-
head, hands, wrists and arms covered
with a papular eruption. Papules
small, pointed, hard, scarcely sensi-
tive, dark, and of coppery color. Had
been in situ several days. Throat
somewhat inflamed, and, upon strip-
ping, found an extensive fine papular
rash over the whole body, of about the
same age as the more pronounced and
comparatively larger papules upon the
exposed surfaces. My diagnosis of
secondary syphilis^ was confirmed by
the woman herself upon the spot, and
afterward by other and more trust-
worthy information. Here there was
every reason to suspect the epidemic
disease, and the attending physician
was by no means to blame for doing
so. Nothing could more nearly re-
semble the papular stage of smail-pox
than the woman's exposed surfaces,
and nothing less than a thorough ex-
amination and the presence of that
almost undefinable something never
absent from .a syphilide could possibly
remove the doubt. (2) A child, fe-
male, about seven years old. Had
been vaccinated ten days before. Over
posterior aspect of hands and extensor
surfaces of wrists and forearms,
around both temples and under chin
were a number of pustules, perhaps
twenty or thirty. They were flattened
on top and covered with thick crusts.
Scratch marks were somewhat in evi-
dence, especially upon the forearms.
Upon examining the vaccination sore,
found copious inflammatory products
present and discharging, and well-
marked linear scars, the result of
scratching. For fear of possible con-
tagion, the father had remained at
home three days already, being an
employee of the I. C. E. postal depart-
ment. Upon reassuring him that im-
petigo was, if not non-contagious, at
least far from dangerous, he with
great satisfaction resumed his employ-
ment. Here, again, the observer (not
anxious, at such a time, to take too
many risks in examining for himself)
was amply justified in being suspicious.
Many cases of varioloid have passed
through the whole disease with less
evidence of an eruptive disorder than
this child presented. Of course, seen
at a time when no question of small-
pox was agitating the public, it would
have cost the physician not a second
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thought; the application of a simple
mercurial ointment would probablj
have been the beginning and end of
his connection with it. But during
other periods, when scores are being
attacked and thousands are in fear,
every skin eruption in the communitj
should be examined, and not only ex-
amined, but definitely pronounced
upon. We should ^Dt be content in
saying it is not small-pox, but should
take pains, and no pains should be
thought too great, to ascertain exactly
what it is. Too many of us have a
comfortable habit, upon seeing an
eruption of the skin, of remarking:
*'0h, it's jutit a rash, and it's better
out than in." Such a procedure may
satisfy in ordinary times, but should
not obtain when small-pox is epidemic.
No eruption, however trivial or insig^
nificant, is without a definite name and
history. To doubt this would be to
insult the memory and reputation of
hundreds of indefatigable workers of
Europe and America who have raised
dermatology to the most exact, com-
plete and precise of all branches of
medical science. (3) In February,
1902, I was requested by the medical
superintendent of the alms-house to
see an elderly female who had been
admitted the evening previous. He
informed me that upon his examina-
tion that mot-ning he had discovered
her to be completely covered with a
papular eruption that very much re-
sembled small-pox. In company with
that gentleman and Dr. T. E. Morris,
at that time in charge of the small-
pox isolation hospital, we found her
in the condition named. A more
equable and complete papular distribu-
tion I never saw. With the exception
of the face, palms and soles, the whole
surface was involved. They num-
bered at least half a dozen to the
square inch, were only of medium size,
were either covered with a pustular
point or else flat-topped and bleeding
or excoriated, the result of beheading
with the finger-nails. Scarcely any
history relative to the eroption could
be obtained from her. A close in-
sp^tion, however, revedbd numeroos
' scars and cicatrices, the sites of older
lesions, as well as parallel linear
streaks, indicating vigorous and long^
continued scratching. The attendants
testified that upon admission she was
in a deplorable condition from dirt,
and that her whole body was the host
of very numerous pediculi corporis.
Indeed, after the vigorous scrubbing
she had undergone, the ova of the
pediculi capitis were to be seen on the
margin of the scalp. Taking these
facts into consideration, it was not dif-
ficult to arrive at a diagnosis negative
to small-pox, and to indicate her dis-
ease or condition by an appellation
fortunately of little use in this country
— phtheiriasis or **louSy disease." Yet,
as before, there was abundant excuse
in a time of general fear, to be exceed-
ingly cautious and suspicious in this
case, and I have no hesitation what-
ever in saying that no practitibner
would have been censurable for impos-
ing a temporary quarantine to await
developments. I might go on, if space
and time permitted, and give numerous
dther illustrative cases met with in the
same epidemic, all of them equally
suspicious, but none of them having
anything to do with genuine variola.
But this paper already promises to be
too long, so I will spare the reader the
infliction. Here we have three in-
stances, however — two of them dis-
eases of frequent occurrence, and one
very rare — of close simulation, clinic-
ally and objectively, to modified small-
pox. Impetigo and syphilis are of
constant happening, especially among
the class in which variola is most liable
to spre^, the city poor living in con-
gested districts and in a dirty condi-
tion.
It would be almost a loss of time to '
name the very many other cutaneous
lesions capable of simulating the grave
epidemic disease under discussion, but,
perhaps, one or two more may be men^
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Diagnostic Features of Small- Pox— Melvin.
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tioned. Herpes, in some of ita man^
forme, might readily excite fear iua
time of general suspicion. More espe-
cially that form of it often called Ay-
droa herpetiformis^ frequently seen in
pregnant , women. Of course a few
days' observation would dear up the
difficulty, but this is exactly what is
generally denied to both patient and
physician at such a time. Again, ery-
thema multiforme might well be mis-
taken for it, in a critical period. I
well remember a very pronounced case
of it I saw two years ago, not when
there was any mention of small-pox,
l^ut in which the patient herself, a
washerwoman, was quite positive she
had the epidemic disease. It is only a
few months since, that I saw a case of
neurotic eczema in a boy of twelve, the
patient of one of our city physicians ;
he was covered completely with a
raised, almost papular eruption. The
rash was so violent that it produced
quite decided constitutional symptoms,
among them being a considerable de-
gree of fever. Seen at a time when
variola was epidemic, no general phy-
sician would have been justified in
leaving the case undiagnosed for twelve
hours. In like manner a number of
other contagious lesions might be
quoted, not, of course, closely resemb-
ling small-pox, and capable of exciting
no suspicion at a non-suspicious period,
but. nevertheless, enough to cause anx-
iety and engender mistakes where
care is not taken, at other times. Any
one can supplement the list for him-
self. The point I wish expressly to
make is that we should not rest satis-
fied in merely coming to a negative
conclusion as regards variola, but in
each and every case clearly define and
indicate the exact name and nature of
the disease. By this means multitudes
of unfounded suspicious and sensa-
tional reports will be set at rest ; iden-
tical diseases afterward appearing in
the same family or neighborhood will
be easily recognized, often without the
interference pf a physician ; and, by
far the best and most important result
of all will be attained, no \infortanatQ
will be spirited oflF to the horrors and
dangers of an isolation hospital with-
out certain evidence of being affected
with the epidemic disease.
3. I come, with much diffidence and
perturbation of spirit, to the discussion
of my third heading — tjie amount and
quality of knowledge requisite to recog-
nize and define the various varieties of
variola. Of course, to that class of
medical men, happily now very small
in number, that think and generally
act upon their conviction that all reg-
ularly qualified physicians are, or
should be, upon a par as regards medi-
cal knowledge in all departments ; that
refuse to recognize anything approach-
ing specialism in medicine ; that believe
that no amount of extra study, extra
opportunity, or extra taste in a certain
direction can make any one superior to
another in any particular; on these
gentlemen, I admit at the outset, my
argument will be entirely thrown away.
But I am persuaded that few, if any,
now listening to me are in that class ;
that none of us are quite so sure of
such an universal uniformity, and I,
therefore, am emboldened to go on
with my case. Who then is the expert
in the diagnosis of modified, obscure,
or suspected cases of small-pox? If
we follow the apparently almost unani-
mous practice of this province, it is the
man who has seen most cases of the
disease. Only recently a gentleman
was brought here from a neighboring
province, at, I suppose, a very consid-
erable expense for this purpose, and
his sole or chief qualification, I under-
stand, was that he had seen hundreds
of cases of the disease. I wish to state
that I speak only from newspaper re-
port, but I believe such report to be
substantially correct. Now, of course,
such gentleman may have had qualifi-
cations far broader and greater than
that I have indicated, but such were
not mentioned, nor do I believe, if he
did possess them, were they the cause
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246
ORIGINAL Articles.
of his selection by our authorities. Is
this then the sole requirement for a
correct differential diagnosis of vari-
ola? I hold it is not. If so, then th^
man who has never seen anything but
a Corinthian column in architecture
would be an infallible judge as to
whether a certain column was Doric,
Ionic, or Corinthian; All these de-
signs have innumerable gradations and
modifications. There may be but an
almost infinitesimal difference in an in-
stance between a modified Doric and a
modified Corinthian . The column may
be really Ionic, but our judge, never
having seen such design, being pressed
for an answer of (and should a negative
reply be returned, great loss may be
experienced by the column's rejection),
what will be his answer? Human nat-
ure being as it is, there are ninety-
nine chances out of a hundred that he
will risk erring on what to him is the
**safe" side, and say that the column
is Corinthian. But to come nearer to
our own profession. What is meant
by the term diagnosis? Does it not,
of itself, naturully infer a choosing?
And, if a choosing, does it not inevi-
tably follow that there must be more
than one to choose from ? And if there
be more than one to choose from and
a correct choice be desired, does not
such correctness depend upon a real
and intimate acquaintance, not with
one of the objects to be chosen from,
but with them all ? Do we not know
that one of the very best and safest
methods of diagnosis is by ''exclu-
sion?'* We have a patient suffering
from fever, cough, etc., etc. We find
he has not pneumonia, that he has not
pleurisy, nor hydrothorax, nor empy-
ema, nor pronounced bronchitis, or,
may be, one of a dozen or more dis-
eases of the chest we may think of,
and knowing also the symptoms of
phthisis, find that he has some of
these, is not this the most absolutely
safe diagnosis that can be made ? Yet,
how could such a diagnosis be possible
to one who has not an exact and fa-
miliar acquaintance with the excluded
diseases? Or, in what position would
an examiner be, if in a suspected
phthisical case, he found many of the
symptoms of other diseases, and not
one unmistakable one of consumption,
and yet know little or nothing of the
other diseases? I say the idea of a
specialism, in diagnosis y of any one
disease, is an anomaly, an absurdity,
and a contradiction of terms. There
can be no such thing. There may be
such specialism so far as treatment is
concerned, but certainly not as regards
diagnosis. Specialism implies an in-
timate, accurate and exhaustive knowl-
edge of a large number of allied or
collateral diseases, or eke of an equally
large number affecting a particular
part of the body. Indeed, the chief
reproach, and the truest one, that can
be brought against specialism, is that
it tends to restrict medical knowledge
to within too narrow limits, and so to
exalt a certain variety of diseases to a
height they are not entitled to. What,
then, can we say of a specialist re-
stricted to one disease, and that, re-
garding diagnosis ! ! If there be a
tendency to exalt a whole variety, will
not that tendency be immeasurably
stronger when it is restricted to but
one disorder? But some one may say
that such a man is likely to have a
knowledge of allied and collateral dis-
eases. If so, the whole question is
settled, and I have nothing more to say.
Such a man is the man in the right
place. But, in the case of the sup-
posed small-pox expert, the very re-
verse is likely to be the fact. Is the
man at the head of an epidemic hos-
pital likely to meet with, and be in a
position to investigate, at his leisure,
cases of psoriasis, syphilis, intertrigo,
phtheiriasis, eczema, and the hundred
and one other cutaneous lesions with
which it is necessary to be acquainted
in dermatology? Is he not, on the
contrary, the man least likely in the
world to meet with such cases ? I feel
I need not push the argument further.
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Cancer of the Prostate— Harrison.
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However imperfectly I have put it for-
ward, and I know only too well its
imperfection, I am sure every reason-
able man will see the point. What is
the reason our medical journals and the
medical world in general is deluged
with such absurd titles as ^'Cuban
itch," **pustular chicken-pox," **Ha-
vana hives," ** Southern scabies," and
scores of othjBr equally senseless and
foolish names? Is medical nomencla-
ture so scanty that this unmeaning
twaddle has to be foisted upon it ? We
all know the reason. These names
are merely the poor coverings of inac-
curate and insu£Scient knowledge; the
inky exudation of retreating medical
cuttlefish ; the spurious coin in place
of the pure gold of medical science.
I need scarcely state, therefore, the
conclusion of my argument except for
the mere purpose of completeness.
That conclusion is that small-pox oc-
cupies no unique position in medicine
as regards diagnosis. To recognize
obscure cases of tertiary syphilis, or of
psoriasis, or of eczema, and, more par-
ticularly, to distinguish one from the
other, requires an intimate and ex-
tended knowledge of diseases of the
skin. To do the like with small-pox
requires merely like conditions.
CANCER OP THE PROSTATE AND THE
SELECTION OP CASES POR
SUPRAPUBIC PROSTA-
TECTOMY.*
Bt Reginald EUlbbison, F. R. C. S.,
Surgeon to St. Peter's Hospital. London, England.
I propose offering you a few re-
marks on the subject of prostatectomy,
and will commence by introducing a
case which may be regarded as a typ-
ical one. I showed this patient at the
Polyclinic a short time after the oper-
ation. Sixteen months have now
elapsed, during which period he has
been actively employed earning his
living. Thus you may judge as to the
♦Delivered at the Medical Graduates' College and Poly-
clinic.
permanent results which we may hope
to obtain in well-selected cases after
this operation.
The patient at the time of operation
was sixty-seven years of age. He has
been under my notice since 1899, when
I performed vasectomy for him for en-
largement of the prostate. At this
time the enlargement had made con-
siderable advance, he was entirely de-
pendent on the catheter, and had been
so for some time, and this greatly in-
terfered with his work as a compositor
and seriously injured his health by
preventing him obtaining suflScient
continuous sleep and rest. The case
proved too far advanced for vasectomy,
and the relief he obtained from this
operation was insufficient.
On February 5, 1902, after examin-
ing his prostate and bladder with the
cystoscope, I performed suprapubic
cystotomy for him and enucleated sep-
arately with my finger the two large
lateral masses I am now showing you.
The prostatic urethra remained intact.
The total weight was five ounces. The
patient made an uninterrupted recov-
ery, the function of the bladder has
been completely restored, and the use
of the catheter discarded since the day
the operation was performed.
If the conditions could always be se-
cured as they existed in this instance,
the operation of prostatectomy would
be attended with very little risk, whilst
the results would be uniformly good.
In the study of the various forms and
structures the enlarged prostate pre-
sents will be found the key to the ap-
plication of operative surgery to this
part.
The first question I would raise is
relative to malignant disease of the
prostate — is it common or not, and
what should be our attitude to it ? My
belief is that carcinoma of the prostate
is far more common than we have been
led to believe. In performing over
one hundred vasectomies on different
persons for enlargement of the pros-
tate, the operation failed to benefit the
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patieDt in several instances, for tiie
reason that the growth proved to be
carcinomatous.
' And this leads me to consider how
we are to recognize this state, and thas
to avoid attempting useless prostatect-
omies. In the early stage there is
considerable difficulty in doing this.
Carcinoma of the prostate is not in^
frequently met with in younger per-
sons than in the ordinary forms of
prostatic enlargement or adenoma.
Cancer of the prostate may occur at or
about the age of fifty, and in this re-
spect corresponds with carcinoma of
the female breast. It is usually asso-
ciated with considerable lumbar and
sciatic pains. Later on it involves
more or less of the chain of glands in
the groin, including the femoral, which
it indurates. Examination by the
rectum not only finds the gland of
stony hardness but of marked fixidity
on pressure. Slight haemorrhages are
occasional, but serious alterations in
the character of the urine and obstruc-
tion to catheterization are often de-
layed. Loss of flesh is usually noted.
These are the ordinary symptoms of
carcinoma of the prostate.
In several instances I have seen,
where the diagnosis was verified by
microscopical examination, the disease
was marked by slow progress and the
slightness of the local symptoms that
were present throughout. It appeared
to prove fatal by the general decay that
was induced rather than by any inter-
ference it occasioned with the func-
tion of micturition, thus contrasting
with advancing forms of ordinary pros-
tatic hypertrophy.
On the other hand, the adenomatous
prostate, which often assumes very
considerable dimensions, and is best
suited for, treatment by prostatectomy,
presents very different local conditions.
When examined by the finger in the
rectum there is a feeling of less fix-
idity about it relative to the pelvis.
The bowel is freely movable over it.
Though firm and bossy to the touch it
is wanting in that feeling of stony
hardnees which is so characteristic of
the carcinomatous prostate.
Where an operation is contemplated
DO examination for the purpose of di-
agnosis can be considered con^ete
without the use of the electric cysto-
scope. Upon this often turns whether
a prostatectomy should be undertaken
at all, or whether the case permits of
the substitution of a more limited pro-
ceeding, as will be illustrated later on.
As viewed by the cystoscope the differ-
ences between hypertrophy and carci-
noma may thus be stated.
Carcinoma of the prostate, in by far
the greater portion of cases, is of a
hard and slow-growing nature, closety
resembling scirrhus of the breast, both
microscopically and to the naked eye.
As a rule there is not very much in-
travesical projection of the prostate in
these cases, and what there is, is of an
uneven and irregular outline. On the
other hand, the large, soft adenoma-
tous prostate presents, as a rule, a con-
siderable enlargement into the bladder
cavity with a smooth, rounded surface.
The most general arrangement of these
adenomatous masses are these: —
(1) As a collar-like general enlarge-
ment of the prostatic ring encircling
the prostatic portion of the urethra.
(2) As an enlargement of the two
lateral lobes, thus squeezing and flat-
tening the urethra from side to side,
the greatest diameter of that passage
thus becoming vertical.
(3) An enlargement of the poste-
rior or middle lobe, either as a sessile,
rounded swelling under the mucous
membrane of the apex of the trigone,
or with a thick pedicle, thus closely
resembling afibro-papillomain appear-
ance.
(4) Or there may be a combination
of any or all of the preceding varie-
ties.
It is thus obvious that the cystO'
scopic appearance of the adenomatous
prostate varies very much according to
the direction of the growth. UsualVy
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the contour oan be made out fairly ac-
cnrately^ aud the observer can say that
he has to deal with a lateral lobe en-
larffonent, a collar-like enlargement
with projecting middle lobe, or an en-
largement mainly of a pedunculated
nature. The importance of this is ob-
vious, for in the last-mentioned case a
simple twisting off of the pedunculated
middle lobe would be sufficient to re-
lieve all symptoms, as I shall presently
show, and is a much less serious pro-
ceeding than removing the whole of
the enlarged gland. It should also be
noted that the mucous membrane
covering the very large adenomatous
masses is often of a peculiarly glieten-
ing character, and sometimes presents
little cyst-like swellings, which, when
viewed in profile, are semi-translucent.
I have not observed this appearance in
cases which eventually turned out to
be carcinoma.
I am laying considerable stress on
the importance of recognizing carci-
noma or cancer of the prostate when
it is the cause of the CDlargement, and
distinguishing it from ordinary hyper-
trophy or adenoma, for the reason that
it may be little short of a calamity to
submit a person to a prostatectomy
should the enlargement eventually turn
out to be of a malignant nature with-
out knowing it. Formerly it was not
a matter of so much importance when
the catheter and the irrigating syringe
represented the mechanisms commonly
employed in the treatment of prostatic
obstruction, for to this extent malig-
nant and non-malignant growths might
be treated on almost identical lines.
At the present time these conditions
are changed, and now that the pros-
tate is approached operatively much
on the same principle as the breast and
other organs of the body, it is of the
first importance that we should recog-
nize beforehand the precise nature of
the enlargement we have to deal with.
I have within the last two years
performed prostatectomy in two cases
which speedily proved to be carcino-
matous. I think such cases should not
be allowed to pass without notice in
relation to the subject I am now deal-
ing with, and I will therefore briefly
give some particulars and show what
was removed.
Case 7. — The first case was that of
a patient, aged sixty-four, whom I saw
in 1901. He complained of frequency
of micturition, both day and night,
and occasionally involuntary dribbling.
A catheter had been passed before I
saw him, but there was no residual
urine. * It was therefore clear in this
instance that the frequency of mictu-
rition was not due to retained urine,
but to some other cause of irritation.
The patient's history pointed to pre-
vious attacks of renal colic, for which
he had been under treatment at Carls-
bad. The last attack of renal colic
had been two and a half years before
I saw him. He had passed uric acid
gravel in the urine, but not stone.
Examination by rectum showed the
prostate to be extremely hard, par-
ticularly at one point, where it gave
the sensation as if a stone was impact-
ed there. Further, the patient com-
plained of dull aching about the but-
tocks and thighs. The muscles were
flabby and the patient was losing flesh.
He complained much of the frequency
of micturition, which disturbed his
rest and greatly distressed him both
day and night. As there was no resid-
ual urine to draw off, the catheter
was useless so far as this symptom was
concerned.
Later on some difficulty arising out
of the increasing size and hardness of
the prostate occurred, and the use of the
catheter then became necessary. Oc-
casionally a few drops of blood werd
passed. I was not able at that time
to detect any enlarged glands either
in the groins or femoral regions. The
patient became very anxious about his
condition, and having heard of cases
where the prostate had been success-
fully removed, he was desirous, other
measures failing, of submitting to this
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operation. I gave it as my opinion
that the case was not a favorable one
for prostatectomy, as it was not un-
likely the growth would recur, and
that there could be no guarantee that
the whole of the disease was removed
at the time of the operation, as in the
case with adenomas involving the part.
On the other hand, the patient urged
the pain and frequency which attend-
ed the introduction of the catheter,
and the uselessness of all the means
that had hitherto been employed to
relieve him. I could not absolutely
deny the possibility of the growth
proving to be one of those densely
fibrous prostates which are occasion-
ally met with. But in my judgment
the weight of evidence was against
this.
However, at the request of the pa-
tient an attempt was made to extir-
pate the gland by the suprapubic
route. I felt to some extent justified
in doing this, for the reason that it
was evident tio long time could elapse
before it would be necessary at all
events to open the bladder for the
purpose of allowing the urine to es-
cape. The prostatic urethra was rap-
idly becoming blocked up by the in-
vading growth and catheterism would
soon be impossible. Prostatectomy
was therefore performed in February,
1902, ^our months after the patient
had been under my observation. The
prostatic mass could not be enucleated
with the finger, and had to be removed
in several portions in this way.
The progress of the case was dis-
appointing. Though the patient re-
ceived immediate relief by the freedom
with which the urine escaped by the
open wound, and got rid of the dis-
tress connected with catheterism prac-
ticed under great difficulty, the growth
within three or four weeks of the op-
eration returned in the original site.
It became necessary to fit a permanent
drain pipe in the suprapubic opening,
which enabled the patient to pass
urine painlessly during the remainder
of his life. The prostatectomy, how-
ever, proved useless, and the patient
died from the recurrence of cancer in
the part four months after the opera-
tion which had been undertaken for
its removal. Secondary growth man-
ifested itself in the spine about the
ninth and tenth dorsal vertebrae. On
microscopical examination the growth
proved to be of a mixed character.
The periphery of the mass was adeno-
matous, whilst the center was carci-
nomatous. The growth cut like scir-
rhus of the breast, and yielded typical
*' cancer juice" on scraping. Mr.
Watson Cheyne saw the patient in
consultation with me.
Case 2. — The second case was that
of a professional man, aged sixty-one,
who consulted me in April, 1901, for
frequency of micturition. As in the
preceding case, the use of a catheter
indicated that there was no residual
urine in the bladder to account for this
symptom, and that some other cause
for it was to be sought. The prostate
was examined per rectum, and it was
fouiid to be large and hard. It was
noted, however, that the rectum was
freely movable over it, and that the
growth was not unduly fixed within
the pelvis. I did not see the patient
again till January, 1902, when the
symptoms had become more urgent.
The frequency of micturition had
greatly increased, and with this a ne-
cessity for the use of the catheter.
These symptoms were so urgent that
on January 5th suprapubic prostatec-
tomy was performed. What was ap-
parently a fibro-adenoma of the pros-
tate was enucleated with some diffi-
culty in two pieces by the finger. The
bladder had evidently for some time
been immensely distended. The
mouths of the ureteral orifices were
so large that they would each admit
the tip of the forefinger. The naked-
eye appearance of the growth was
that of an adenoma, which the first
microscopical examination confirmed.
A further examination,' which included
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Cancer of the Prostate— Harrison .
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a complete section of the mass re-
moved, unmistakably indicated its car-
cinomatous nature as in the previous
case.
Early in April, 1892, this patient
sailed for the Cape in a professional
capacity, apparently in excellent health,
and passing urine quite naturally.
About four months after operation he
had one or two slight attacks of htema-
turia, which were evidently connected
with recurrence at the original site.
He was able, however, to complete
two more voyages out and home, when
he returned to this country with the
abdominal cicatrix and contiguous
glands largely involved in carcinoma,
and with the scrotum and legs much
edematous. This had all taken place
within the course of sixteen months.
During the last few months my at-
tention has been called to several in-
stances of prostatic enlargement, which
should be included with those I have
just mentioned. They are not cases
which should be submitted to prosta-
tectomy. At all events, the prospect
of recurrence should have full consid-
eration.
But though a deliberate prostatec-
tomy may not be advisable in cases of
this kind, there can be no doubt that
carcinoma of the prostate often,
sooner or later, leads to conditions
where operative interference is called
for; I refer more particularly to
the effects of obstruction so caused
upon the contents of the bladder. A
suprapubic opening may give immense
relief to *the patient whose bladder is
distended with clots or foul urine.
This is a substitute for a catheter
which may be advantageously utilized.
I would like to say a few words in
reference to some modern develop-
ments relative to the treatment of cer-
tain inoperable forms of prostatic ob-
struction. I refer to those instances
where the enlargement is presumably
of a cancerous nature. It is a painful
thing for a surgeon to say to a patient,
**I cannot advise the removal of your
enlarged prostate, for the reason that
it is probably malignant." ** Is there
nothing you can offer?" is probably
the rejoinder to this. Within the last
few months my attention has been di-
rected to the use of the Roentgen rays
and high-frequency currents in some
of these inoperable cases of prostatic
carcinoma to which I am referring.
This is ground upon which I would
tread with much caution. My interest
was first drawn to this subject by some
admirable papers on the use of the
x-rays and the Finsen light in connec-
tion with the treatment of lupus and
other semi-malignant forms of ulcera-
tion. At the present time I have two
cases of malignant disease of the pros-
tate, or what I take to be such, under
daily treatment by means of these
agencies. In alleviating pain, and in
apparently favorably influencing the
further development of these growths
as judged by the patient's sensations,
physical condition, and examination of
the part with the finger, I am favor-
ably impressed by what I have seen.
The process is a painless one, and will
be continued on the ground that it
appears to have contributed to the
comfort of the patients. It seems im-
possible that so powerful an agency
can be brought into contact even mo-
mentarily with living tissues without
influencing their nutrition. Whether
for good or for evil, or for neither in
instances such as these, has yet to be
determined. I think, however, from
what I have seen, it is worth a trial,
and this it is having.
To revert. I opened these remarks
by illustrating what may be regarded
as the total enucleation of the contents
of the prostatic capsule. I will now
consider some cases where partial pros-
tatectomy may be substituted.
If we study a number of specimens
of enlarged prostates, we shall find in
a certain proportion that the obstruc-
tion is occasioned by a limited portion
of the gland which has become hyper-
trophied or excessive. The most com-
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moD form of this variety is where the
floor of the gland becomes pendulous^
and by blocking micturition renders
the nataral escape of urine as impos-
sible as if the orifice of the bladder
were commanded, by what is known in
mechanics as a ball valve. In all other
respects these prostates are naturally
disposed. Let me illustrate what I
mean by a case.
In April, 18i^9, 1 saw, at the request
of Sir Douglas Powell, a gentleman,
aged fifty-five, who was suffering from
stone in the bladder. I performed
litholapaxy upon him, and removed a
stone composed of oxalates and phos-
phates weighing over one-half ounce.
I should mention that he had been
using his catheter for twelve months,
and had been absolutely dependent
upon it for three weeks before the op-
eration. The patient made a rapid
recovery from the operation, though
he was never able to dispense with the
use of the catheter afterwards.
In August of the same year the op-
eration of litholapaxy had to be re-
peated, as in this short interval an-
other stone had formed, which was
also successfully removed in the same
way. On this occasion the stone was
formed of phosphates, which is the
usual kind in the case of recurrences.
Again he made a speedy recovery so
far as the removal of the stone was
concerned. The patient, however,
still remained dependent on the use
of the catheter. By September, 1900,
he had formed other stones, which
were removed in like manner. He
still remained dependent on the use of
the catheter. For the fourth time, in
February, 1901, he again applied to
me with symptoms of stone. Feeling
sure that this rapid recurrence of stone
was not due to any fault in the opera-
tion or to any want of care on the part
of the patient or his medical attendant,
before proceeding to remove the stones
I examined the patient with the cysto-
scope. The view thus obtained of the
interior of the bladder was extremely
interesting. There was no enlarge*
ment of me lateral lobes of the proa*
tate, but the third or middle lobe was
prolonged, and took the form of a
pendulous mass which projected up-
wards into the bladder, and evidently
played the part of a ball valve.
Thus the urine was mechanically
prevented escaping from the bladder^
except when the catheter was used,
and being allowed to decompose, the
formation of phosphatic stones neces-
sarily followed. I should add that
under cover of the projecting lobe of
prostate a portion of two calculi were
seen by the cystoscope. This condi-
tion at once explained how these stones
were formed, and I decided upon re-
moving that portion of the prostate
which was hypertrophied, as well aj
the stones it partially concealed. It
seemed to me quite unnecessary to r^
move the entire prostate, and I there-
fore advised the minor operation.
This was done by opening the mem-
branous portion of the urethra on a
grooved staff, as if for median lith-
otomy ; this enabled me to pass a pair
of forceps into the bladder, with which
I seized and twisted off the polypoid
excrescence of prostate as you see in the
specimen. Subsequently I withdrew
two calculi and introduced a temporary
perineal drainage tube into the blad-
der. In a few days the latter was
withdrawn, when the wound rapidly
closed.
It is now over two years since this
operation was done, the patient has
had no further recurrence of stone,
and what is also of great importance,
he has never had occasion to use the
catheter since, though he had been de-
pendent upon this instrument for so
many years previously.
It was quite clear in this case that
the partial enlargement of the prostate
which I have described was the direct
cause of the recurrence of stone from
which this patient suffered for so many
years. Further, this case illustrates
the great assistance the cystoscope
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Cancer of the Prostate— Harrison.
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affords in ali cases of this kind. It
old^y showed how limited the pros-
tfttie ealargeoient was, and how this
could be removed by a very idmple and
safe operation* The days are now
past when the cystoscope was regarded
as a toy. Every one who desires to
obtain a practical knowledge of the
disorders affecting the urinary tract
must make himself acquainted with it
if he desires to diagnose and treat cor-
rectly the disorders of this part.
Partial operations on the prostate
must be limited to such conditions as
I have just illustrated. They are not
to be recommended when the entire
organ is more or less involved in a
hypertrophy. Two instances have re-
cently come under my attention where
no permanent good followed supra-
pubic cystotomy and the removal of
some portions of the enlargement. In
one the suprapubic opening never
closed, as the urine failed to escape
by the natural channel, whilst, in
the other, though the suprapubic
wound healed by the aid of a retained
catheter, the patient could never dis-
pense with the latter instrument. In
the latter case I advised that an at-
tempt should be made later on to rec-
tify this by a more complete enucle-
ation of the balance of prostate that
remained. This I heard was followed
by a most satisfactory result, the pa-
tient within a month after the revised
operation obtaining full voluntary
power over the act of micturition, be-
sides other advantages.
There is another point to which I
should like to refer in connection with
the subject of entire enucleation of the
prostate as now practiced.
There can be no doubt that in the
majority of these cases the prostatic
urethra is more or less damaged, if
not'estirely removed. This is evident
from the elimination of specimens
after removal.
This mass, which weighs three
ounces, and the stone below it, was
removed from a gentleman, aged sixty,
in November, 1901. He had been
completely incapacitated from profes-
sional work by the constant use of the
catheter. He is now in excellent
health and urinates normally, though
his prostatic urethra was included in
what was removed.
The question has been raised, ^^Is
there not some liability to what
amounts to a urethral stricture after a
wound of this kind?" I have met
with an instance where there is some
evidence of this being the case. The
prostate was removed from a gentle-
man, aged sixty-seven, in February,
11*02. The urethra was somewhat
freely separated on the anterior aspect
of the prostate in front of the junction
with the membranous portion. The
whole canal was no doubt much tough-
ened by the very long dependence on
the catheter, and by no less than eight
crushing operations for stone which
had preceded the prostatectomy. Since
the latter operation this patient has
had some trouble in passing urine.
Sometimes a good stream passed, at
others no urine could be voided until
after the introduction of a bougie. A
good stream then immediately fol-
lowed. Apparently there was an ob-
struction of a valvular nature which
thus caused the difficulty in urinating.
It could not be called a stricture, as
after the hitch was overcome just at
the entrance to the bladder a No. 14
metal bougie, English gauge, passed
easily. Three months after the pros-
tatectomy I passed a urethrotome and
divided what seemed to be a fibrous
band or bend at the point where the
hitch occurred. This completely freed
the urethra for all purposes and the
patient has since had no further
trouble in urinating naturally with a
large stream.
The narration of the last case leads
me to give prominence to a method
of dealing with some forms of pros-
tatic enlargement which seems to have
some advantages I will presently note.
In 1881 I read a paper before the
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Original Articles.
Royal Medical and Chirurgical Society,
based on some cases where tumors of
the prostate had been saccessfully
enucleated in the course of operation
for stone in the bladder, by lateral
and bilateral lithotomy, and I advo-
cated the proceeding as bearing upon
the remedying of prostatic enlarge-
ment **by means other than those
commonly recognized/'*
The most striking case I then re-
corded was that of a man, aged sixty-
seven, with a large oxalate stone in
his bladder and an hypertrophied pros-
tate, who was sent to me by Dr. H. G.
Samuels, when I was surgeon to the
Liverpool Royal Infirmary, and upon
whom I operated in September, 1881.
As the stone and prostate were both
large I made a bilateral section of the
latter by means of which I removed
the stone with forceps and enucleated
with my forefinger the obstructing
prostatic mass, which proved to be a
considerable adenoma. The patient
made a good recovery and completely
recovered his voluntary power of mic-
turition. The specimen was again
shown at the Manchester meeting of
the British Medical Association (1902)
in the course of a discussion on pros-
tatectomy.
In the discussion which followed the
reading of my paper before the Royal
Medical and Chirurgical Society, Sir
Henry Thompson, Sir William Savory
and Mr. Christopher Heath took part,
when it was stated by the first named
speaker that my suggestion **was
practical and well worthy of consider-
ation."
After the lapse of twenty years I
have deliberately applied the process
which in my first paper I regarded as
*<an accident" occurring in the course
of a lateral lithotomy operation. I
have very little doubt, in the light of
what is now being done in regard to
prostatectomy, more especially in its
relation to cases complicated by vesical
stone, that what I described as being
* Trans. Royal Mod. Chlr. Society, vol. bcv.
undesignedly done in 1881, probably
represents in 1903, in conjunction with
the closure of all perineal cystotomy
wounds, by the use of sutures and
suitable drainage tubes, a most efficient
and rational method of dealing with
this combination of disease. Li this
way provision is made for the removal
of the stone, the obstruction contained
within the prostatic capsule, and for
restraint of haemorrhage in a combined
manner which has not been previously
attempted. I will proceed to mention
particulars of a case where this process
was recently employed.
It was that of a member of our own
profession, whom I saw in February
this year (1903). Twenty-five years
previously he had a stone removed
from the bladder by crushing, by Mr.
Christopher Heath. He remained
well until two years ago, when symp-
toms of enlarged prostate caused
him much continuous pain. I
examined him under an anaesthetic
later on, and found the prostate uni-
laterally enlarged to a considerable
extent. Though he was not depend-
ent on the catheter his calls to urinate
were frequent and distressing, and I
concluded that it was best to make an
exploratory incision within the area of
the prostatic capsule, and to remove
an obstruction which I believed to be
what Sir Henry Thompson described
many years ago '*as a prostatic tumor
encapsuled in the interior of the
gland."
For this purpose I made the ordinary
incision as for lateral lithotomy, which
gave free access through the membra-
nous urethra to the prostate and en-
abled me to readily remove the tumor
I am now showing. It is figured ex-
actly as removed by enucleation with
the finger.
It will be seen that it is about the
size and shape of a tennis ball. Had I
required more room or found it neces-
sary to enucleate the opposite lobe, the
bilateral incision through the prostatic
capsule would have provided this.
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Cancer of the Prostate— Harrison.
256
Enucleation was readily effected by
using the two forefingers of my right
hand whilst downward pressure was
exercised above the pubes with the
left, the entire operation only occupy-
ing a few minutes.
One of ray gum-elastic drainage
tubes was passed through the wound
into the bladder, and the incision
closed around it firmly with sutures.
I would incidentally mention that
for some years preceding the more
general adoption of litholapaxy as a
substitute for lithotomy, 1 had been in
the habit of thus closing perineal
wounds made for the latter purpose.
In this way haemorrhage was arrested
and by conveying the urine outside
the bed patients were kept dry through-
out.
Further, the dependency of the
drainage as compared with suprapubic
-cystotomy certainly favored more rapid
repair. . In forty-eight hours or so the
«tiff gum-elastic drainage tube, which
permits of side-packmg with gauze if
hsemorrhage continues, was removed
and a soft rubber one, with control tap
for the urine, was substituted.
The patient left hospital within a
fortnight from the date of operation,
though the wound had not completely
healed. His condition is greatly im-
proved and the function of micturition
is so completely restored that he is
looking forward to resuming profes-
sional employment. Two months after
the operation I had the pleasure of
submitting the patient to Mr. Heath,
together with the growth that had
been removed.
An idea may be formed as to the
amount of room afforded for with-
drawing a growth or etone from the
bladder, and for conducting the neces-
sary manipulations with the finger,
from the accompanying diagram. It
was made from the transverse section
through the middle of a frozen gland,
-and shows the lines of a lateral and a
bilateral section, as well as other di-
rections of incision. In the enlarged
prostate these dimensions may be con-
siderably increased without impinging
upon the capsule^ It will be observed
that the downward or upward incisions
through the prostatic area from the
urethra, which would correspond with
a median perineal section, offer a more
limited access as compared either with
the lateral or bilateral incision, single
or combined. Further, the latter two
will drain incontinently without a tube
should this for any reason be required,
whilst this is not the case, or very im-
perfectly so, with the median sections.
Further, it is to be remembered that
the downward incision into the gland
necessarily sacrifices the ejaculatory
ducts, should this be a point deserving
consideration.
The chief advantages connected with
this form of prostatectomy are that
the bladder is not opened, no portion
of the urethra is removed, the after-
treatment is more comfortable to the
patient as not entailing a suprapubic
opening, and a more rapid convales-
cence.
The procedure I have described is an
interesting example as to how history
may repeat itself in connection with
surgical work. Further, it illustrates
how accidents, or what Paget spoke of
as ^'calamities in surgery," may be
importantly utilized. We have another
illustration of this in the failures of
nephrotomy, contributing to the devel-
opment of important observations in
connection with the treatment of some
forms of albuminuria and nephritis by
surgical means, a subject in which I
have also been much interested.
In two instances I will briefly narrate
suprapubic prostatectomy followed -
some weeks after perineal drainage
had been employed for the relief of
retention and purulent cystitis. In each
case at that time the patients were in
too serious a condition for submitting
to removal of the prostate.
The first instance was that of a pa-
tient aged sixty-three, who I saw in
consultation early in 1901 with Dr.
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Skartnan, of Sydenham. There was a
preyioas history of a severe spinal in-
jury, and the local condition rendered
it likely that there was a suppurating
sac entering above the large prostate,
the contents of which were discharged
into the bladder. For two years he
wore his control drainage tube with
considerable comfort, and his health
improved. After consultation with his
medical attendants. Dr. Umney and
Dr. Hale White, I advised a suprapu^.
bic prostatectomy, which was per-
formed in March, 1903. Six months
after this operation he writes me, <*I
have, been to Brighton for a month.
The amount of pus does not decrease,
but the removal of the prostate cer-
tainly has caused me to suffer far less
inconvenience."
The second case was that of a pa-
tient aged seventy-three, who I saw in
consultation with Dr. E.J. Lewis, Mr.
Edmund Owen and Sir Thomas Smith
during the early part of 1903. His
condition in the first instance was a
very serious one from prostatic ob-
struction and suppuration. As a tem-
porary expedient, as in the previous
case, perineal puncture was performed.
After this he improved slowly, and as
there was every prospect of his having
to wear the drainage tube for life he
preferred to undergo, later on, a more
radical procedure. His appetite and
strength having been greatly restored,
perineal prostatectomy .was performed
five months after the previous opera-
tion. There was nothing particular to
note except that a stone was found
concealed by the lobes of the prostate.
He had been sounded previously with-
out it being detected. Its relation to
the prostatic lobes showed this to be
impossible. The Roentgen rays might
perhaps have indicated its presence.
Both wounds healed well and quickly,
the perineal opening favoring this by
supplying a means for dependent
drainage.
In reference to the mortality of
prostatectomy, I do not think the
number of cases or the periods of time
they cover are sufficient at present to
enable us to iurive at conclusions
which can be deemed very guiding or
conclusive. Information for this
purpose should be of the fullest kind;
and include partial as well as complete
prostatectomies, whether suprapubic
or perineal. I am not at all sure
whether what are called **partjal pros-
tatectomies" are not the more fatal
of the two, as these would include the
malignant and fibrous types of pros-
tatic enlargement, as opposed to the
adenomas, which are easily and quickly
shelled out with little or no heemor-
rhage. *
I am disposed to think that the mor-
tality which would embrace these va-
rieties is not much less than what
Fuller placed it in his earlier articles *
on suprapubic prostatectomy, namely,
15 to 18 per cent. Even if brought
down to a 10 per cent, mortality this
should make us careful in advising it
or in setting aside what the catheter
and the wash bottle can do, though
fully admitting the inconvenience of
these.
If these operations were confined to
the enucleable adenomas, or to use the
term applied to them by Sir Henry
Thompson, prostatic tumors encapsul-
ed in the interior of the gland, I have
very little doubt that the mortality
would be considerably lessened. It is
where severe structural lesions have
to be inflicted for the purpose of ef-
fecting removal with the finger where
risk comes in, in the form of shock
or hemorrage, and it is to some of
these cases that the term partial re-
moval is assigned for obvious reasons.
Enlargement of the prostate is a
wide subject, and permits of a good
deal of variety in treatment, operative
and otherwise. In placing these views
before you I think we are much in-
debted to my colleague, Mr. Freyer, for
the communications he has made, here
and elsewhere, in reference, more es-
pecially to suprapubic prostatectomy.
•••Diseases of the Gealto-Urinary System " (Maemil-
Ian, 1900).
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Segregation of Lepers— Martin.
Sd"?
SBQREOATtON OF LBPBRS.
Bt 6. G. Mabtui, X. ]>M 8t. LomU.
In Norway leprosy is so oommon
that the goverDiuent has f o«ad it nec-
essary to provide hospitals or what
they call ** Homes" for the treatment
and care of this class of patients. In
Bergen and Trondhjem elaborate insti-
tutions of this kind have been estab-
lished, in each of which an average of
one hundred and fifty patients are un-
der treatment. In these institutions
these unfortunate people are treated
with the greatest tenderness and al-
lowed the utmost personal liberty con-
sistent with the welfare of the com-
munity. Dr. Lee has charge of the
sanitarium at Bergen, and Dr. Sand is
in charge of the institution at Trondh-
jem. Dr. Hansen has supervisory
control of these establishments, but
spends the most of his time visiting
cases in various parts of the country
which have been reported as leprous.
His diagnosis determines the fate of
the patient he visits. If he happens
to be a leper, he is sent to one of the
^ 'Homes," otherwise he is not dis-
turbed. In Bergen the **Home" is lo-
cated in the central part of the city,
but in Trondhjem it is built on the
outskirts of the city, and in both insti-
tutions the inmates are allowed, if in
good p)iysical condition, to visit any
part of the city they wish, provided
this is done with permission of the
physician in charge. Dr. Sand has
been in charge of the institution at
Trondhjem thirty years, and Dr. Lee
has been in charge of the *'Home" at
Bergen twenty years. Both of these
gentlemen told the writer that they
had never known a healthy person to
contract the disease by oomins: in con-
tact with leprous patients. This also
included the nurses and attendants of
these institutions. In other words,
they did not believe the disease was
contagious. They were in favor of
segregation because under this system
better medical attention was provided
1^ bett^ hygiene enforced, and tliese
w^e the best means of preventing th^
spread of the disease. These views
surprised the writer, as he knew Drf
HsAsen, who is at the head of the lepr
rosy management in Norway, was the
father of the lepra bacilkis, and pro-
fessed to believe in its contagious ten-
dencies. Both Dr. Sand and Dr. Lee
affirm there is no curative treatment
for leprosy, but that occasionally a re-
covery would take place spontaneously
under judicious hygienic management*
Dr. Sand kindly furnished me with
some important statistics of the insti-
tution in Trondhjem, of which he has
been director from 1861 to 1900, an
abstract of which is herewith ap-
pended.
The relation of the different forms
of leprosy to each other is as follows :
1707 cases had been treated during
the long period of about forty years.
Of these, 588 persons, from different
causes, had been discharged from the
institution, and 1124 had died. The
number of tubercular cases (1145)
was more than double that of the
maculo-anesthetic lepers ( 533 ) . With
reference to sex, the numb^ of males
( 1080) was nearly double that of fe-
males (598). The difference between
the number of treated maoulo-anee-
thetic males (327) and tubercular f^
males (392) is relatively insignificant;
while the number of tubercular males
(75;5) is about four times as great as
that* of the maculo-anesthetic females
(206). The same statistics show that,
in all, 1124 died in the institution; of
these, three-fourths (835) from the
tubercular form, and only one-fourth
(289) from the maculo-anesthetic;
about two-thirds (733) were males,
and only one-third females (891).
Altogether, 442 (297 males and 145
females) were on the following grounds
discharged: Cured, in all, 6(1 male
and 5 females). In addition to these,
several recovered who preferred to re-
main in the institution. Admitted for
observation, and later (as non-lepers)
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discharged, 28 — namely, 12 males and
16 females. On the grounds of in-
sanity prior to 1880 (when there was
no department for insane), 7 were dis-
charged. Discharged for improper
conduct, 46 ; of whom 33 were males
and 13 females. Discharged for a
variety of causes, 41. TransfeiTed
for various reasons to another institu-
tion, 18. Left without permission,
296 (males 209 and females 87). Of
the above discharged invalids, 199
were taken back, amon^ whom, how-
ever, was none of those dismissed as
cured. Since 1880, when a department
for insane was established, a total of
798 lepers have been treated. Of these,
47 were insane ( 23 males and 24 fe-
males). Of these 47 insane cases, 10
(4 men and 6 females) came from
other institutions. Deducting these
from the 47 cases, there are 37 left,
which gives a percentage of 4.70 to
the whole number treated in the insti-
tution (788).
The medium age shows itself two
years higher in tubercular males (39.91
years) than in tubercular females
(37.77 years), although the duration
of the disease in males is about three-
fourths of a year less (9.24 years)
than in females (9.98 years). This is
explained by the fact that, in the tu-
bercular form, the average age at the
outbreak of the disease is about three
years higher in males (30.69 years)
than in females (27.79 years). In the
maculo-anesthetic form, on the other
hand, the medium age in males is
about two years less (50.74 years)
than in females (52.57 years); as,
however, the duration of the disease
in males is about five and a half years
shorter (14.28 years) than in the
females (19.76 years), the relation re-
mains the same so far as the average
age at the outbreak of the disease is
concerned.
In this form of the disease females
are about three and one-half years
younger when they are attacked
(32.81 years) than the males (36.46
years). With respect to the period of
treatment in the institution, the lepers
who are admitted have on an average
passed more than half of the period of
sickness (11.24 years) at home (6.93
years), and only a part of the last half
in the institution (4.31 years). And,
also, it maybe said that the females
defer their entrance longer still (7.64
years) than the males (6.54 years).
The difference is mainly limited to
those affected with the maculo-anes-
thetic form, for the duration of the
disease before entrance to the institu-
tion for tubercular males and females
is nearly the same (5.68 and 5.84
years), while for the males affected
with the maculo-anesthetic form it is
9.98 years, against 12.45 years for fe-
males of the same form. The medium
age for both sexes and forms of the
' disease together is 42.33 years. The
age at the outbreak of the disease for
both sexes and forms of the disease is
31.09 years; therefore, the duration
of the disease for both sexes and forms
of the disease is 11.24 years. The du-
ration of the disease before admission
to the institution for both sexes and
forms of the disease is 6.93 years.
The treatment period in the institution
for both sexes and forms of the dis-
ease is 4.31 years. The relation of
the disease to married couples is as
follows: In 478 marriages between
lepers and non-lepers, only 15 cases
appear where husband and wife were
attacked. In 5 of these cases the hus-
band and in 10 the wife first became
leprous. In 463 of 478 marriages no
infection followed. This gives a per-
centage of non-infection of about 97.
When we consider that the outbreak
occurs mostly at the age of ^marriage,
that is from 20 to 40, we cannot avoid
the conclusion that leprosy, as a rule,
is not conveyed from individual to in-
dividual by constant contact. It is
generally accepted that the disease is
caused by the lepra bacillus, but the
only reason for this belief is found in
the constant presence of this bacillus
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GenitO'Urinary Anatomy— Lewis.
250
in the disease. No well-authenticated
case of its production hj inoculation
has ever hekxk recorded, and that is the
only reliable means of deciding this
question. In view of the evidence we
have that leprosy is practically a non-
contagious disease, it is doubtful
whether any government is justified in
isolating or segregating these uqfprtu-
nate people against their will. .At all
events, before they are deprived of
their liberty, it devolves on the gov-
ernment to prove beyond a doubt that
tjiey are a menace to the health of the
community in which they live.
porary , relief ; while a permanent ci^re
may be expected from operative meth-
ods, backed up with regftlar treatment
covering a good length of time.
A mistake not infrequently made by
persons is to*^believe they have strict-
ures when they have none. T^iejLare
examined, fotr instance, with a sonand
which runs up against the cut-off mus-
cle, making a definite ^ and decided ob-
struction to the further entrance of
the sound; the case is diagnosed as
'* stricture" when there is none — the
obstruction having' teeti produced by
a perfectly normal affair, the cut-off
muscle.
A Pj^fN TALK ON MATTERS PER-
TAININQTO QEMTO'URtNARY ANAT'
OMY, PHYSiOLOQY AND
DISEASES.
[CONTINUID rSOM SBPTKMBIB ISSUE.]
By Dr. Branstobd Lfcwis, of St. Louis,
Professor of G^euito-Urliiary Surgery, Mariob-Sims-Beaa-
mont Medical CoUeee; ConstUtant in Qenito-Urlnary
Surgery. to the Female Hospital, Bebekah Hos-
pital, etc. ; Member of American Association
of Genito-Uri'nary Surgeons, American
Medical Association, Etc.
Stricture of the Urethra is an ab-
normal narrowing of the urethra at
some point or points (Fig. 15); usu-
ally caused by either uncured gonor-
rhea or some direct injury, such as a
fall astride of a fence or against the -
pommel of a saddle. Scar-tissue forms
from either of th^se two causes, and
in the course of time (Contracts, nar-
rowing more and more the caliber of
the urethra, lessening the size of the
stream and interfering wij:h the ready
outflow pf the urine. If neglected, it
tends to grow worse, and also to dam-
age other of the urinary organs.
Stricture cannot be cured by medicines
given in any manner or form; cor-
roding applications of ''medicated
bougies'' used for '*eating out" the
stricture dimply cause more scar-tissue,
ultimately making matters worse, in-
stead of better. The regular passage
of steel sounds will stretch and in-
crease the caliber of the strictured
urethra, giving grateful, if only tem-
Chancroid, Chancre and Syphilis.
Chancroid is an aggressive, local
ulcer, usually or venereal origin, ob-
tained in intercourse with an infected
person of the opposite sex, although
it is possible to be infected from an
unclean, contaminated closet or article
of clothing. It is a localized pro-
cess, not involving the system of the
affected individual. This is in marked
contrast to chancre^ or syphilis^ which
is a systemic disease, involving, in
different persons, every organ or part
of the body, and also presenting the
various manifestations of the affection
at any point, either inside or outside ;
and. these various manifestations, in
the first and second stages of the af-
fection give rise to secretions that are
contagious and capable of inoculating
with syphilis any healthy person com-
ing in contact with them.
It is for this reason that the possi-
bility of a person acquiring this dis-
ease innocently or accidentally is so
great. The babe or the wife, in using
public utensils or closets, are alike
endangered with respect to accidental
contagion.
Chancroid is a virulent and rapidly
spreading, though local, ulcer, while
chancre is an indolent and slow-going
process, giving rise to no pain or even
tenderness, often. It reminds one of
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GenitO'Urinary Anatomy— Lewis,
tb« axiom: ^Great oak» from Ikti»
tfeoras grow^" ae it ia Ihft first stage
or «rifi>eiioe of the <iBu»fti ol barge
p n a aiWiti eg, sypbilis. The ohaiKre
itself createe ac^ little ^fistturfaiHKe a^me-
times that it k everio^kttd entirely,
and the first that the patient observes
is the later outbreak, the skin erup-
tion. Chancre and chancroid are
separate and. independent affections,
bearing no relationship to one another;
they may be inoculated onto the same
individual, however, bed. will pursue
their oaaal course, the chaacroid going
tkv^ugh ita eourse ^pmkly asd healing
up, pdMibly, before the ehanere W*
giita to make itself manifest.
Being a purely loeal disease^ chan-
croid dbes not require any ^etemic
traatment f o« its cure ; and the giving
of mercury **t» keep it out of the
Ufiied" is n serious errer that brings
about eonf usioj:! and regret on variooa
aceoonts* If the sore m a sypfaiUtio
chancre^ it eannat possibly be kept
oui of the Uood,. no* matter haw aet-
iTely medicine may be given ; and if it
is not syphilitic, it will not get into the
Mood, whether medicine be given or
not. The correct plan, in suck caaes,
ia to aeeept only local treatment, un*
less a syphilitie infection ra proved by
the development of a skin eruption^
Off patches in the mouth, etc., after
whMh comprehenrive and systemic
treatment should be carried ost until
the patient is cured.
The diagnosis of ^philis should not
be mnde on the local evidences only ;
th^ are too erratic and deceiving to
enaMe one to determine wbethdr there
Fig. 10. — DQstructtoB of bone by syphilis.
Fig. 11.— Tertiary syphilitic ulceraiion. .(^P?
pia).
Fig. 12. — 8cc€Midary syphilis.
Fie. 13. — Destnictien of eyes and nose by
syphilis.
Fig. 14. — Loss of hair from syphilis.
Fig. 16. — Strfctnre of the male urethra.
Fig. is. — Large ehancroid in female.
Fig. 17. — Destruction of eye, nose, and parts
of face by hereditary syphilis.
Fig. is. — Later aecondary syphilis.
ia or is ftet a syphiUilia as well as a
ehaneroidal inf e«iaoi>-^wbether it is a
^^hflvdf" or a ***»lt'* seare, a» active w
an indolent one. Tiako akn^y and th«
dbvelopniant or non-development of en
eraptioa» eto«:» can positively deter*
mino the noaliter.
Syphilie is ordinarily divituble inAn
three stages of progreae: the irst,. or
primary; the second, or aeeoedary,
and the third, or t^tiary. The early
manifesftationa of the disease are in-
clined to be superficial^ kut numeroua ;
the later ones, deeper and more sci-
ons, sometiofess even destroying ti»e
organs or parte of the body affected,
ae shown in some of the aiQeompe^y-
ing illustratione. While it is desirable
that some of the early indications, ap-
pemr^fNT the sake of penaitting a
positive diagnosis, if nothing more —
the later ones should be prevented by
sujffitsieney of treatment.
Tosoeure a conqplete aad permanent
cure, the disease- requires prolonged
treatment J over severtd years. This
element of Hme is a necessary and im- '
peitant one. Heroic or over-vigorous
treatments laeting but a few weeks or
months, whether takea at Hot Springs
QC not, do not suffice for permanent
cure; the disease may become latent
for a shorter or longer period as a ve*-
suit, but it it liable to break out at
any subsequent time, after months or
years. On the other band* if the
treal;ment is cajrriied on steadily and
•suffieieptly orw thet required length of
tirne^ a defisate and permanent cure
may be expected in the large majority
of cases; and, moreover, the same
measures are usually «jb^»essful in
keeping the disease under control
throughout its early, active and ag^
gvef^sive^period^and -wkhouit intei:ruf4*
ing the patient's work or usual voear
tion, besides wardinic against the
frightful blemishes of face or figuroto
which neglected syphilis, leads. It is
the negfecied cases that are f olrlowed
by innumerable reeurrenees, locoiao-
t<»r ataxia, paresb, nerve-degenera*
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tioDs and hereditary transmission.
Sach effects are seen in the clinics
among the poor classes, now-a-days —
among people who have not the energy
or the time or the opportunity to take
the proper care and treatment. Prac-
tically the one exception to this rale is
that in which a particular case is un-
usually aggressive or rebellious, which
sometimes happens. It is such cases
as these that should be sent to Hot
Springs, Arkansas, occasionally. There
they are enabled to take a much larger
dosage that is required, and, also, they
make a business of attending to their
needs in a regulai* and systematic man-
ner. Ordinary cases do not require
treatment at Hot Springs.
He^^maphrodism. — ^This is a condi-
tion about which there is much specu-
lation by the general public — a condi-
tion of double genital equipment, that
is supposed to afford the possessor the
beatific ability to hold intercourse with
either sex. As a matter of fact, the
condition is more ideal than real. Of
the many cases that have been dis-
cussed in medical literature, as well as
the numerous ones that have not come
to the literary surface — there is hardly
a hamlet that does not lay claim to the
dignity of numbering a *'morphodite"
among its inhabitants— only a half
dozen or so have been proved to be
real hermaphrodites, possessing gen-
ital organs of both sexes (testicles,
penis, ovaries, womb and vagina) ; all
the rest have been spurious, or, as*
they are termed in medical parlance,
pseudo-hermaphrodites. Two such
cases are illustrated: one a male, with
a blind pocket resembling a vagina;
the other a female, with an enlarged
clitoris resembling the organ of the
male. Unless perverts, their sexual
inclinations are toward the opposite
sex, as they should be naturally.
Confusion and life-long embarrass-
ment sometimes result from lack of
information on this subject by parents
who, not recognizing the true situa-
tion, allow a child to grow up as a boy
or a girl, and do not discover the true
sex until adolescence is attained, when
a change in clothing and associations
is attended with newspaper notoriety
more generous than desirable.
627 Century Building.
jT
SOME CASES OF HYDROCELE CURED BV
IODINE AND CARBOLIC ACID IN-
JECTIONS.
Bt J. 0. LUK«, M. D., Ocilla, Georgia.
I have had quite an experience in
the last six or eight years with hydro-
cele in almost all ages, from one^ year
up to sixty-five. Will report some of
the worst and then my method of cure :
Case 1. — J. B., white, age thirty-
eight years. Following history: Five
years ago while loading a bale cotton
on wagon strained himself in back
badly, and felt effects of strain in right
testicle at time, but paid very little
attention at time to it, but in a month
or such a matter, noticed that testicle
was enlarging, which kept on until it got
so large it was burdensome and greatly
in his way while walking about or at-
tending to his farm work, and for last
year had been unable to plow or do any
work on farm. When he came tome,
I was surprised at his being able to go
around at all. When I saw the enor-
mity of his scrotum, it reached near
half way to his knees and was so tense
until almost felt hard like tumor, and
he complained of heavy dragging pain
in his back and would feel nauseated
all the time. I found on close examina-
tion that I could outline the testicle,
so I took hypodermic needle and passed
into sack and found the clear-like
fluid, after which I inserted a cocaine
injection as low down in sack as I could
to miss testicle, after which I took a
small [trocar with canula and passed
into sack, withdrew needle and let fluid
escape, and found that I had twenty-
eight ounces ; after which I took eqiml
parts carbolic acid and iodine, two
ounces,' and with rubber sjnringe passed
through canula into sack and kneaded
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Multiple Chancre in the Negro— Lofton.
268
the empty sack and testicle gently
but thoroughly, after which I let what
of the solution would pass out,
through the canula and had him lie
quiet for half-hour, after which put
him on a well-fitting suspensory and
sent him home six miles, and he re-
ported to me in ten days as cured and
has remained so up to this time, which
was about five years. He never com-
plained of pain at any time from
the treatment and got up and walked
out to buggy when ready to go home.
Case 2.—D. M., white, age sixty-
one. While riding horseback eight
years ago, his horse fell into a hole
and came near throwing him off and
mashed his testicles, and he suffered
severely for several hours, when got
easy and thought nothing more of his
trouble for some time. Now he
found his right testicle was giving him
some trouble and gradually growing
larger, which condition went on for
near eight years, only giving him slight
trouble ; it then got to where it gave
him some pain and he came to my
office, a distance of thirty miles, and I
drew off nearly two ounces of fluid and
injected same as other case and let him
go home, but two years later he re-
turned in same condition and I carried
him through the same treatment again
and made a cure up to time of his
de^th, which was three years after.
Case 3. — Child, two years old ; fam-
ily history good ; health good. Three
months ago mother noticed right tes-
ticle swollen, and had father to bring
him to my office. On examination,
found he had hydrocele, and I followed
my plan on other cases and made a
cure, which was four years ago. And
I have several other cases I could re-
port, but this is sufficient and conclu-
sive that the injection will cure most,
if not all cases. I have in my experi-
ence had to repeat the injections in but
two cases, and they were both cured
with second injection. And I have had
no after-trouble in any case. Had no
pain in but one case, and that was a case
in which I left a quantity of the iodine
and carbolic in the sack, and it set up
no trouble, but caused the old man a lot
of pain for about six or eight hours,
but his case was cured ; and should I
fail on second time, I would continue
just as long as my patient would let
me do so to use the same treatment.
I believe it will cure all cases of hydro-
cele that are curable.
MULTIPLE CHANCRE IN THE NEQRO.
By Luckn Lofton, A. B., Ph. D., M. D,. Emporia. V».
Ex-President Seaboard Medieal Auociation of Virginia
and North Carolina.
The text-books at the command of
the writer refer to dual chancre as be-
ing exceptional. This thoroughly co-
incides with my experience as f ai* as
the white and semi-white race is con-
cerned, but, upon the other hand, it
has been my experience to observe, as
a rule, double chancre (especially
when located upon the genitalia or its
covering) in the negro subject. In
fact, out of twenty-nine cases of syph-
ilitic infection that came to me for
treatment so far this year (1903),
twenty-one were negroes ranging m
color from a ginger-cake brown to a
•*charcoal white"the ages rangingfrom
two years to fifty-three years old ; six
were mulatto women, and four were
deeply colored, though they were born
that way (colored). The one aged
two years presented a double chancre
of the '<stub," one immediately be-
hind the left side of the crown, and
the other almost surrounded the mi-
nute orifice of the glans. The fore-
skin, as is usual, was quite long, and
was easily retractable. His married
first cousin was responsible for his
condition, though she only possessed
the classic alpha. No treatment other
than cleanliness was given this baby,
as developments were needed to com-
plete the diagnosis. In due time all
necessary evidence was produced. The
reason this little patient was found in
this condition was due to the fact that
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Original Articles.
h» oootinaally toyed with his gewtals
and cried when any undue prcssore
wa^ i»ada thereon.
The ten women displayed the genu*
ine Hunterian product, from the lab)»
major» to the os nteri. One case,
however, especially, which impressed
me among the ten, was a married
woman who had a chancre located at
the anterior fourchette, and one on the
tip end of the second finger of the
right hand. She was a '* washerwoman"
and having her hands submerged a
great deal in strong lye-water gave
rise to an artisan's eczema, and no
doubt while either examining her gen-
itals or masturbating, the sore finger
was thus inoculated about the time
the initial lesion appeared; or, more
probable still, in manipulating the
male organ she was infected.
Another member of the above pre-
sented a double chancre of the left
labiae minoree, situated about one-half
inch apart. The remainder are not
worth a detailed description.
In regard to the ten men, every one
but two possessed redundant prepuces,
a thing you will observe in ninety-five
per cent, of your negro G. U. patients.
Circumcision is an unknown luxury to
the **coon'' in the South.
Two displayed dual chancres of the
lining of the prepuce, three had double
chancre of the distal . portion of the
foreskin, while four had them located
in and around the meatus urinarius.
One presented a most interesting pict-
ure in that he went the other nine one
better, and presented three well-
defined so-called initial lesions. This
is the only case of the kind I ever saw.
He was a Baptist deacon, and was no-
toriously popular among the fold, evi-
dence of which (in a sense) was incon-
testable. I purposely avoided any
cautery or astringent measures in this
instance; in fact, I saw him every
we^k for three months, and had him
wear apiece of ''medicated" absorb-
ent cotton to ''absorb" the "sores," a
hing he most readily assented to, for
in his youth be had ^'bhmdered and
was burned," and dreaded the sight of
AgNOj, HNOs, or any of the mild
measures so fondly held in reserve for
such cases by the wily G. U. man.
These lesions ran a most desirable
course, and each appeared to do its
best to be classic in every acceptation
of the term. The secondary manifes-
tations came on in due time and then
the diagnosis was clinched. Under
appropriate treatment they faded away
like snow under a noonday sun.
Now as to the cause of the dual
chancre in the negro.
Both male and female are in many
instances extremely loose in their
methods of cohabitation ^ and cleanliness
is a thing commonly tabooed. A great
many of the colored women who de-
light in carnal pleasure and abuse, do
so on the sly and in consequence no
attention is paid to hygiene. Then
i^ain, some are so polluted as to par-
ticipate in carnal indulgence with from
two to ten men in one night without a
thought of cleansing themselves. They
keep company with the lowest order of
negroes and white men, and being ig-
norant and indifferent: to the law of
hygiene, never think of Investigating a
possible partner's approech. I have
known really decent appearing colcnred
women to cohabit with syphilitics who
were in the worst stages of the disease
and who came to me for treatment
afterwards with a "flying out" of the
skin, as the women call a secondair
eruption. Being closely questioned,
would impart the knowledge that so
and so "gave it to them." The<je wo-
men are very often trusted cooks
among splendid .white families, and
not a few are nurses.
Belative to the male element as to
the probable cause of his contagion,
elongated prepuces that keep the glans
penis continually in an irritated condi-
tion, filth and a possible susceptibility
to syphilis.
The negro at his best is an amalga-
mated being, and it is reasonable to
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Sexual Vigor im the Male-Boynton.
DM
assert that the powem of resistance
are a great deal less in his otganism
tkan he of a pare and undefiled
Then consider hia mode of living,
hie food, his clothings ht& debauches,
and his lack of intelligence regarding
isatter^-fact affairs and jou will
oeaee to troncter.
Think of ten in a family living on
five dollars per month and sleeping
huddled in one small room without
ventilation, even when one or more
might lie ill with typhoid fever or some
such dtaease. He sleeps, hot or cold,
with his head buried under cover. I
have entered such a cabin early in the
morning and upon ent^ing, before any
ventilation had taken place, the stench
I'd meet would be almost unbearable,
and physicians are not choice, either,
regaining odors.
The greatest curse that overshadows
the negro's pathway today is his igno*
ranee of the laws of sanitation and hy-
giene. When he is lifted from his
thraldom of ignorance, superstition
and the immoral slough in which he
has paddled about in for nearly fortj'
years, his body will be a mass of pure
muscle and his brawn equal to with-
stand the ravages of disease from all
quarters. As he is now, instead of
fighting for a better and purer moral
and physical life, he drifts and ebbs
with his surroundings, not caring for
future generations, but relies, with the
strictest obedience, upon the old prov-
erb, ''Sufficient unto the day is the
evil thereof.''
<r
CAVSBS OF IMPAiRED SEXUAL VtOOR IN
THE MALE.
By C. B. Boynton. M. D., SmithAelcU Utah.
Admitting that hereditary causes,
trauKuatism and non-venereal diseases
may sometimes be followed by sexual
weakness, this article will be based
upon the cases that iu fifteen years
have come to the writer's notice.
Not all cases of heart disease are
sexually weak, yet some are, and thus
in their effort to perform their^ duttee
creditably may inflict further injvary
upcfto their hearts and other eorgans.
The moral effect of informing such
men that their over^strong sexuality m
killing them is good.
Viewing themselves in this way they
will exercise self-restraint, but infovm
one of these men that his wealc heaort
ia undermining his sexual system and
he will go ahead and kill himself.
The relation that venerea) diseases
bear to sexual weakness has been
hugely handled by abler pens than
mine and I wiH mit rehash the sub-
jeet.
I wiD not deny but in some cases
masturbation has led to sexual weak*
ness, but my observation leads me to
believe that the actual masturbation of
itself causes very little sexual weak-
ness. The masturbater that has read
quack literature and is hypochondri-
aea) is another thiog.
Two years* asylum practice con-
vinced me that where the insane zstA
idiotic masturbate the habit was surely
caused by the mental disease and not
the mental disease by the habit. Fur-
thermore, I believe that an able-bodied
insane man is not injured much, if any,
by masturbation. The best worker
we had in the asylum was the worst
masturbater in the institution. He was
a garrulous, witty patient, a great
reader, rational for a few minutes, in-
clined to make the most of his in-
sanity, optimistic, lively, very excita-
ble, usually cleanly ; at times maniacal
and withal the most interesting and
harmless man in the institution. At
forty, although he had masturbated
every day or oftener for twenty years
or more, erectile power was prompt
and perfect. If my m^nory serves
me right, this man's insanity dated
from some acute disease in childhood.
Epileptics are frequently mastur-
baters, but it takes more than mastur-
bation to cause epilepsy.
My none too extended observation
leads me to believe that children of
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great mental and scholarly precosity
have smaller sexual organs than others
with less grey matter. That the female
''scholar" certainly is more often the
girl with an infantile uterus, is a well-
known fact. One prolific cause of
sexual degeneracy is sexual excess
stimulated by intemperance. Many of
these unfortunates have masturbated
in their past and continuing their ex*
cesses in drink, blame their sexual
troubles to youthful indiscretion.
Plenty of men who are sexually as.
able as they should be, borrow much
trouble from the fact that under cer-
tain circumstances they begin to doubt
their power. The male sexual func-
tion should never be insulted by doubt,
else it is very apt to act in an unbe-
coming manner and cause the patient
more anxiety. Doubt often starts from
the fact that conscience is hurting the
man or discovery is likely. His com-
panion may ridicule him and his doubt
may become very alarming. Then
when he reads the ad. of some quack,
he is rendered half insane with fear,
he introspects; begins to '<treat,'' and
with loss of appetite and sleep becomes
in many senses an invalid.
Then there is the married man whose
wife does not respond and even allow
him connection under protest. The
fault may or may not be hers, but the
best sexual system in the world will
degenerate under such conditions. In
time with such a wife a man will have
perfect erections until the act itself,
then the function fails ; again he may
ejaculate prematurely because she is a
little kinder to him than usual ; or still
again he may lie awake all night ready
to act but restrained by her refusal.
When at last she submits he fails by
pure exhaustion and she may make his
state more horrible by anger and dis-
gust.
There are men who lejarn to fear a
wife's reproof, so that this fear para-
lyzes them sexually.
How different is the lot of a man
whose partner flies into his arms with
ardor, from that of him who has to
overcome a mountain of objections ere
he can gain the goal where he is not
welcome. The one may continue sex-
ually perennial until eighty and the
other fail to function perfectly at
forty.
But is this failure of woman to do
her part sexually different from what
might be expected? I think not.
1. Girls should be reared for mar-
riage ; not to be self-supporting spin-
sters.
2. Women should be taught that,
sexual apathy is something to their
shame or an indication of infirmity,
and then they will, as they should,
separate from a husband when it is im-
possible for them to experience sexual
pleasure.
3. Religious teachers should impress .
the idea that it is the duty of all m>r-
mal human beings to have offspring.
That it is as much a sin to disobey the
commandment, "Multiply and replen-
ish the earth" as it is to lie or steal.
Without the desire for offspring the
furnace of love is left without fuel
and care becomes a monster. A civil-
ization too elaborate for maternity is
sounding the knell of its own doom;
it is cowardly and selfish. No wonder
in such events Cupid dies and Psyche
becomes sexless. The pith of the diffi-
culty lies in the pervei^sion of woman;
the avoidance of conception ; the strug-
gle of womankind to become inde-
pendent and self-supporting.
In the presence of this feminine
perversion the male also tends to be-
come a sexual pervert and degenerate.
This is not laying the burden of the
blame upon woman, for, considering
the intemperance of the male sex, it is
no wonder that so many women desire
to be independent. When a man
learns to love his beer and tobacco bet-
ter than he can love a home and a wife,
we would expect that girls, as a mat-
ter of self-preservation, will plan to
become self-supporting.
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Parasitic Scalp DiseaseS'<jOttheil.
367
SVBLAMINB IN THE TREATMENT OP
PARASITIC SCALP DISEASES.
By WlLIiLAJI S. GOTTHWIi. M. D.,
Dermatoloeist to theOity Hospital, Lebanon and Beth
Israel Hospitals. New York City.
When sublamine was introduced as a
non-irritant disinfectant equal to mer-
curic chloride in bactericide energy,
and possessing far greater powers of
tissue penetration, it at once occurred
to Dr. Gottheil that the drug had a
most important sphere of usefulness,
not only as an external antiseptic, but
also as a remedy in various parasitic
dermatoses and as an antiluetic. For
the toxicity, causticity and irritancy of
corrosive chloride limit its use iii the
former and make its injection in syph-
ilis our last resort instead of the regu-
lar treatment.
Sublamine was found by Eroenig,
Blumberg, Schenck, Zaufal, Paul, Sar-
wey and others to* possess the same
bactericide power as the bichloride,
but to be so non-irritant that even 2
per cent solutions can be employed if
required, and to have a far greater
peneto-ation than the older drug, as it
does not coagulate albumen.
During the winter of 1901-2 a ring-
worm epidemic broke out in a large
orphan asylum to which Dr. Gottheil
and Dr. George H. Fox were derma-
tological consultants. The matter was
brought to their attention only when
the epidemic had assumed alarming
proportions. Some four hundred and
fifty out of the nine hundred children
were affected. Many, of course, had
only a light form, but there was a large
proportion of deep infection and kerion.
The serious nature of such a state
of affairs is well known. Kingworm
of the scalp is not, ordinarily, a grave
affection ; but even under the most fa-
vorable circumstances and with the
most careful treatment it lasts for
months. In public practice the ma-
jority of cases are not cured at all.
They go from clinic to clinic, getting
now a little better and now a little
worse, until puberty is reached and the
malady cures itself. Meanwhile these
children are excluded from school and
grow up in the streets. A similar
epidemic in the institution some years
before had nearly led to its permanent
closure.
The diagnosis was confirmed by mi-
croscopic examinations and cultures,
and a laboratory was organized for
both methods and the control of re-
sults. Proper isolation was enforced;
and observation wards were instituted
in which apparently cured patients
were kept for three weeks after treat-
ment was ceased. No case was dis-
charged until cure had been repeatedly
proved. All other necessary sanitary
and therapeutic arrangements were
made. One hundred and fifty of the
infected .girls were transferred to Dr.
Gottheil's skin service at Lebanon
Hospital.
The patients were divided into
squads. Every head was closely shaved
once a week as soon as the inflamma-
tion had subsided sufficiently to permit
it. Twice daily each head was thor-
oughly scrubbed with brush, green
soap and hot water.
The remedies employed were chrys-
arobin, formalin, croton oil, bichloride
of mercury, carbolic acid, iodine, and
ethylenediamine-citrate of mercury and
sublamine in various strengths.
A most determined effort was made
to have proper records kept ; for here
was a chance to determine by compar-
ative tests which plan of treatment
gave the best results. Dr. Gottheil
was not successful in this, however.
Lack of discipline and the fact that
often the names of the children were
unknown or imperfectly known, or in-
terchanged, helped to create confusion.
The patients were scattered in four
buildings and at least a dozen wards.
Lack of room necessitated incessant
transfers of well and sick children.
Changes in staff and servants further
complicated matters. Hence the rec-
ords were in a very unsatisfactory state
when the epidemic was ended.
\
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Chrysarobhi was soon abandoned.
It was impossible to keep the children
from getting it into face and eyes, and
there was a good deal of trouble with
dermatitis and conjunctivitis. The dif-
fuse brown stains on the skin doubled
the time required for examinflction. The
Same objection was made to iodine.
This in combination with goose grease
has lately been highly recommended
by Dr. Jackson, or New York, and is
undoubtedly an effective preparation.
The menstruum is comparatively ex-
pensive, however, for use on a large
scale, and it caused coloration. At
Dr. Fox's suggestion a number of
cases weri> put upon it, but treatment
was soon changed.
No definite results were obtained
from saUcylic acid in any form and
concentration. The same is true of
pure carbolic acid, followed by alcohol
when too irritating. Pure formalin
was used in some cases by a house
physician without Dr. Gottneil's con-
sent. It cured the patches to which
it was applied, of course, but at the ex-
pense of sloughing and destruction of
scalp tissue. In 10 per cent, solution,
which was well borne, it did not seem
to make much change in the patches.
Bichloride, sublamine and crotoji oil
were found sufficient for all cases.
The first was employed in 1 : 1000 so-
lution, but many could not stand its
vigorous use twice daily, and often only
1:2000 could be used. Its effect was
very slow, probably because of deficient
penetration, but we persisted in its use
for purposes of comparison. In most
cases final recourse was taken to 33 per
cent, of croton oil. This was applied
several times in succession until a vig-
orous reaction took place. Then an
ordinary soothing application (usually
3 per cent, salicylated oil) was used
until the inflammation subsided, when
the bichloride was again employed.
Of the two ethylenediamine-mer-
cury compounds, sublamine was more
largely used. At the time the epidemic
began the citrate was the only prepara-
tion obtainable ; but since the proper-
ties of the two are similar they can be
considered together. They are much
less irritant l^n hleUbwle. All stood
1:1000 sublamine -very well; indeed,
in obstinate cases 1 : 750 was used with-
out trouble. Stronger solnttons than
that, however, gave trouble. It is pos-
sible, of course, that the shaving and
scrubbing rendered the scalps hyper-
sensitive. But sublamine is much less
obnoxious to tender or inflamed skins
than bichloride and can be used in
about twice the strength permissible of
the latter.
Over one hundred cajses were treated
with sublamine. As with the other
dru^s, they were not selected but in-
chided cases in all stages of the affec-
tion; some had merely a single patch,
whilst others were in an advanced and
generalized stage of the disease. In
the latter class were a number of older
children who had had ringworm of the
scalp for years and whom we suspected
with good reason to be uncured cases
from an epidemic of several years ago.
They had been for months and years
at Bandall's Island, the city institution
for orphans, and had been sent back to
the asylum as cured. That this was
not the case, hdwevor, is shown by the
fact that some of them formed part of
the contingent of chronic scalp cases
that were ^ways present in the asylum
and which undoubtedly formed the
nucleus of the present epidemic. Some
of the cases were not cured when tl^e
epidemic ended. Dr. Gottheil believes
that they belong to the small number
of really incurable cases and that their
retention in the institution wilt lead to
further trouble.
All others did very well indeed under
sublamine. Its action was naore rapid
than that of bichloride, as. might be ex-
pected from the fact that with equal
bactericide power it has greater pene-
tration, and can be employed in nrach
stronger solution. There caabe no
doubt that it was the most effective
treatment employed.
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Parasitic Scalp Diseases— Cottheil.
260
Dr. Eckstein assisted in the micro-
scopic and bacteriologic test for the
presence of ringworm at the beginning
of the epidemic. The astonishingfact
was noted that a parasite indistiogaish-
able from that of ringworm could be
cultivated from scalps that were ap-
parently perfectly healthy. The tri-
chophyton was seemingly present on
most or all the scalps, possibly in an
attenuated or non-virulent form. Per-
haps it was the usual form kept in de-
pressed growth by prophylactic meas-
ures. The bacteriologic test of 6ure
was therefore abandoned and only
macroscopic evidences relied upon.
Cases in which repeated cultures had
been made with negative results, and
which were therefore discharged as
cured gave positive cultures later,
though their scalps were appparently
healthy.
V^
UVf^RlDROSIS OF THB PBBT TREATED
BY FORMALIN.
From observations made on soldiers
in the French army, Vaillard reports
favorably upon the results of formalin
treatm^it for excessive sweating of
the plantar surface of the feet.
The effect of formalin is to deo-
dorize the perspiration when it is
fetid; to harden the epidermis,
thereby avoiding the consequences of
maceration; to diminish or totally
suppress the glandular secretion by its
action upon the epithelium; and fi-
nally to heal the excoriations by its
local antiseptic action.
The strength of solution employed
varies from the commercial formalde-
tyrde (40 per cent, formalin) to 2.5
per cent., according to the nature of
the case. If there is much maceration
{Mid excoriation of the skin, the weak-
est dilution should be applied at first,
and then rapidly increased in strength.
The m^etfaod of application is to
bandage wet compresses to the soles
of the feet three or four times in the
twenty-four hours, care being taken
to protect the interdigjtal surface,
rince here formalin causes great pain
and often excoriation. The p^iod
dufing which the applications are
made necessarily varies from twenty-
four hours to eight days, according to
the strength of the solution used. In
those cases in which the pure formal-
dehyde can be used the cure is almost
immediate. The benefits derived from
the treatment are only temporary,
lasting from a few weeks to three
months, but are quickly renewed by a
repetition of the applications.
ANESTHETIC TO THE URETHRAL
TRACT.
Bt B. MiAD Hammond. M. D.. BxAndjr Station, Vlxginia.
In introducing a catheter or bougie,
as an anesthetic to the urethral tract I
use —
BL Antipyrine,
Pow. camphor aa 5 J
Liq. alboline xj. s. ft. J iv
M. Sig. — Use an ordinary glass ear syr-
ingeful as an injection into the urethra a few
minutes prior to introducing instrument. It
will render the operation comparoiively
painless.
CLINICAL LBCTVRBS ON DISEASES OF
THE SKIN.
The governors ef the New York
Skin and Canc^ Hospital announce
that Dr. L. Duncan Bulkley will give
a sixth series of clinical lectures on
Diseases of the Skin in the out-patient
hall of the hospital on Wednesday
afternoons, commencing November 4,
1903, at 4:15 o'clock. The course
will be free to the medical profession.
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New Publications.
NEW PUBLICATIONS.
DiSKABBS OF TUB Skin. By Maloolm Morris. W. T.
Keener & Co., Chicago. 1903.
This very neat and reliable manual
on diseases of the skin will prove serv-
iceable as a guide to the student, and
convenient for reference purposes to
the general practitioner. Many im-
provements have been made in this
edition, both by additions and elimina-
tions. The book, as it now appears,
is up-to-date, conservative, practical
and thoroughly trustworthy in its
teachings. It deals largely with the
fundamental principles and practice of
dermatology, without devoting any
special attention to divergent theories
or minute details of treatment. The
strong points of the book consist in a
clear presentation of disease with a
brief mention of the best methods of
treatment. This is a merit seldom
possessed by the average manual of
skin diseases.
Analysis OF THX Sexual Impulse— Lovs and Pain—
Th» Sexual Impulse in Women. Third volume in
the aeries, '^Studies in tiie Psychology of Sex." By
Havblook Ellis, L. S. A. (England) , Fellow of the
Medico-Legal Society of New York and Anthropo-
logical Society of Berlin; Honorary Fellow of the
Chicago Academy of Medicine, etc. ; general editor of
the Contemporary Science Series since 1890. Extra
cloth, $2.00 net, delivered. Sold only to physicians,
lawyers, clergymen, advanced teachers and scientists.
Philadelphia, Pa.: F. A. Davis Company. Puhlishers,
Nos. 1914-16 Cherry street.
The above book contains a vast fund
of information on a subject which is
seldom discussed, but of vital impor-
tance to society, especially from an
anthropological and medico-legal stand-
point. The author is admirably
equipped for the study of sexual psy-
chology, but the subject takes such a
wide range and is so difficult to mas-
ter, that its complete elucidation from
available data is a hopeless task. Sex-
ual instinct and sexual impulse are so
multiform in their manifestations, both
normal and abnormal, that they be-
come unfathomable, and hence insus-
ceptible of analysis. The author,
however, has, at the cost of much
time and labor, obtained data from an
immense variety of sources that have
enabled him to turn a bright light on
the different phases of this interesting
subject.
Diseases of Infancy and Childhood. By Heket
KOPLIK, M. D. Lea Brothers & Co., Philadelphia,
Pa. 1903.
While, in late years, there has been
an abundance of literature on the sub-
ject of pediatrics, it has not been
available to students and physicians in
the form of elaborate text-books em-
bodying the results of aggregate re-
search. This work, however, takes
cognizance of the progress in pediatric
science made by the English, Ger-
man, French and Italian nations, as
well as American, and at the same
time the author states clearly and
forcibly the results of his own obser-
vation and clinical experience. The
various subjects discdssed are presented
in the following order: Infancy and
childhood, premature infants, diseases *
of the new-born infant, injuries in-
flicted during birth, specific infectious
diseases, diseases of the mouth, phar-
ynx and larynx, diseases of the gastro-
enteric tract, diseases of the respira-
tory tract, diseases of the heart and
pericordium, diseases of the nervous
system, general diseases, diseases of
the lymph nodes, ductless glands, and
diseases of the blood, diseases of the
bones, diseases of the liver, diseases
of the kidneys and diseases of the skin .
The Internal Seobbtions and the Pbinoiplbs of
Medioine. By Chables E. De M. Sajous. M. D.
Vol.1.- F. A. Davis Co., Pablishers, Philadelphia,
Pa.
The above volume is remarkable for
its departure from the beaten paths of
investigation, and both on account of
its elaborate preparation and the
pre-eminent standing of the author in
the medical profession, is entitled to
careful study by every progressive
member of the profession. The
theories herein set forth, if fully sus-
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WMch yields thirty times its vol-
ume of •• nascent oxygen *'
to the condition of
is daily proving to phj-sicians, in
some new way, its wonderful efScacy
in stubborn cases oi BoMema^ Paoriasia, Salt Rbeuta, Itoh.
Barber's Itohf Eryaipelaa, Iry JPoiaoving, Ringworm^
Herpes Zoster or Zofia, ete. Acne^ 'Pimples on Pace
are cleared up and the pores healed by NYOROZONC and GLYCOZOMC
in a way that is
magical. Try this
treatment ; results
will please you.
FuTI method of treat-
nent In my book,
•* The TbeiapeuticAl
Applications of Hy*
drosone and Glyco-
sone ' ' ; Serentecnth
Edition, 33a pafres.
Sent free to physicians
on request.
Prepared pnly by
Chemist and Graduate of the ** Ecole Centnle des
Arts et Manu&ctures de Paris " (France)
57-59 Prlnc« Street, New York
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273
Nmw Publications.
tained by practical demonBtratioto^ will
necessitate a readjastment of the f un-
daoaeotal principles of medicine. The
author claims that the ant^ior and
posterior pituitary bodies are the gov-
erning oent4M*s of all Tital processes.
That, while the antwior pituitary body
insures oxygenizati^i of the blood
through the adrenal s^retion, the pos-
terior pituitary body adjusts and gov-
erns the functional activity of all the
organs through the nervous system.
That the thyroid gland, the anterior
pitwtary body and adrenals are func-
tionally united and constitute thB ad-
renal system. That symptoms of dis-
ease are manifestations of over-activ-
ity or insufficiency of the adrenal sys-
tem. The inference to be drawn from
these premises would seem to be that
the primary object of treatn^nt of dis-
ease should mainly consist in an effort
to restore and maintain a normal phys-
iological action of the adrenal system.
It is not advisable to hastily accept ^>r
reject the findings of the author. His
views are frankly and ably presented,
and are deserving of thoughtful oes-
sideration.
Thb AiOEBiOAir PooKCT Mkdioal Diotiokakt. Edited
by W. A. Vbwman Dorland. M. D. Oontatuhiff
the Pronnnolatlon and Deflnitton of the Prfnolpai
Wordi Used in Medicine and kindred leienoes. With
566 pages and 64 extensive tables. Philadelphia,
New York, London: W. B. Saimders ft Company.
1903. Flexible leather, with gold edges, $1.00 net;
with thumb index, $1.25 net.
In this little work, now in its fourth
edition, we have a pocket dictionary
equaled by none on the market. It is
a wonder to us how the editor has got-
ten so much information in such a
small space. In this edition several
thousand of the newest terms that
have appeared in recent medical litera-
ture have been added, and the entire
work subjected to a careful revision.
Since the work has come to us for re-
view we have had many occasions to
refer to it for definitions of new words,
and in no instance have we been dis-
appointed. We believe that the work
in its new form will meet more fully
than ever a realdmuand on the part of
physicians and atudents.
ThI AMIBIOAir ILLXTSTIULTKD Mn>IOAL DlOTIONAHT. FoT
PraetitioneTS and Students. A Oomplete Dictionary of
the Terms Used in Kedielne, Snxiery, Dentistiy. Phar-
macy, Chemistry, and the kindred branchea, imdud-
ing much eollateral information of an enoydabodie
eharaeter. together with new and elaborate Tables of
Arteries. Musdes, Nerres. Veins, etc.; of Bacilli.
BaotMla, Microcooei, Stmptoeooel; Spovymie Tables
of Diseases. Operations. Signs aod S y m pto ms, Stains,
Tests, Methods of Treatment, etc., etc. By W. A.
Newman Dosi^and. A. M., M. D.. editor of the
"American Pocket Medieal Dictionary.*' Handsome
Inse octavo, nearly SOO paffes, bound in full flexible
iMither. Philadelphia. New York. London: W. B.
Saunders & Company. 1903. Priee, ^.50 net;
irith thumb Index, 96.00 net.
The rapid exhaustion of two large
editions cannot butbegrattf3dng proof
to the editor and publishers that this
exceQeat work meets the varied needs
of physicians and students better than
any other dictionary on the market.
In this (the third) edition several
hundreds of new terms tliat have been
added to the vocabulary of medical
sciences have been incorporated and
clearly defined. The entire work,
moreover, has evidently been subjected
to a careful revision, and many of the
tables (notably those of Acids, Bacte-
ria, Stains, Tests^ Methods of Treat-
ment, etc.) Jiave been amplified, And
their practical value greatly incvemed.
It is only by such constant and care-
ful revision t^at a medical dictionary
can hope to reflect the progress of
medical science, and the usefulneoB of
this work by this present revisk>n has
been very largely extended.
Thv Lover's Wobld. By Aliok B. Stockhak. M. D.
Published by Stockham Publishing Co., Ohieago.
The theme of this book is as old as
tlie hills. It has been celebrated in
song and tftory from time immemorial.
It is a subject that has been studied
for ages, and is still an unsolved prob-
lem. Eivery man, woman and child
think they understand it thorouglily,
but when they undertake to define it
they first begin to realize how little
they know about it. This book takes
up the subject of love and treats 4t in
a masterly style. If it fails to deGne-
ate its true character, it at least por-
trays in a most engaging manner what
it ought to he.
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IMPORTANT
FACTS
III
Pertaining To The IMOft Rational Treatment For INDIQE8TION.
INGLUVIN
Not only Relieves the Symptoms, but Removes the Causey by
its Peculiar, Active, Bitter Principle.
IT
TONES UP THE STOMACH
INCREASES THE DIGESTIVE FERMENTS TO NORMAL
STIMULATES THE GASTRIC AND INTESTINAL MOTOR ACTIVITY
AS SISTS NATURE TO CARRY ON A NORMAL PHYSIOLOGICAL
DIGESTION
PILL IHamVIH COBP- (waESTifE)
" ■— A COMPRESSED PILU UNCOATED.
Comi>ines all the excellent DIQESTIVE action of Ingluvin with
the additional therapeutic value of Nux Vomica, Aloln and Qingerin.
IT
INCREASES THE BLOOD SUPPLY OF THE GLANDS AND
MUCOSA OF THE STOMACH AND INTESTINES
PREVENTS CONSTIPATION AND ACTS AS A CARMINATIVE
INQLUVIN is Indicated In all forms, including Nervous Dyspepsia,
whether in the acute, sub-acute or chronic stage*
maUIVIN IS A HMITIVE SPECIFIC FOR VOIUTINa IN 8ESTATI0N AUD THE
POST NAUSEA FROM ANESTHniCS, CALOMEL^ ETC
Pil«serlb«d In th« sam* nnannar, do«e and combination aa Papain. '
lITEMTURf AHO UMPin OHHIIFIHIT SEMT OH REQUEST.
WHEN PRESCRIBINQ, SPECIFY WARNER A CO. AND AVOID SUBSTITUTES
WM. R. WARNER. & CO. "-'-"A'S«..™„
Phiiadeiphlay New York, Chicago, New Orleans.
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974
Therapeutic Suggestions.
THERAPEUTIC SUGGESTIONS.
SPECIFIC URBTURITIS.
The following will be found to be
most successful in the treatment of
specific urethritis:
Bl Resorcin, 1 per cent 5^
Sig. Use as an injection four times a
day.
For internal treatment the following
should be administered :
Bt Uriseptin (Gardner-Barada)....giv
Sig. One teaspoonfnl in hot water four
times a day.
ECZEMA AND STOJHATITIS.
Bt H. Knox StxwAbt, M. D., Philadelpliia, Pa.
Some months ago a gentleman pre-
sented himself at my office. He was
suffering from a complication of dis-
eases. He was very miserable, much
depressed both physically and men-
tally. His lips and mouth were cov-
ered with a sort of fungus growth, a
sort of spongy excrescence, which pre-
vented him from eating! His body
and limbs were covered with a rash
which resembled at first that of con-
fluent measles. This rash soon began
to crust, itched intolerably and scabs
fell off, leaving a raw, excoriated sur-
face. Internally, I gave mere. cor. 6x,
sulphur 30x and acid carbolic 6x ; lo-
cally, I employed glyco-thymoline
alone. I used it in varying strength,
from half and half to full strength ; it
soon cleansed up the mouth and lips,
which permitted the patient to eat
food readily and thus improve his con-
dition.
He now made rapid progress. The
glyco-thymoline stopped the itching
and healed up the skin, leaving it as
clean and clear as a baby's.
PALATABLE VET EFFECTUAL.
There is a wide-spread belief that
physicians as a rule consider well-
founded that cod liver oil is not only a
remedy of decided power, but a food
of very high value. Every physician
knows, however, that a very large
number of patients who should and
doubtless would get much good from
it cannot or will not take it. This is
largely due to the fact that the ordi-
nary preparations are so nauseating as
tq cause serious digestive disturbances,
while in many cases the stomach will
not even retain them. It is "hotorious
that the so-called **tasteless" prepara-
tions are, indeed, tasteless because
they contain no cod liver oil, but there
is a preparation that contains all the
potent elements of cod liver oil in a
form pleasant to the taste and agree-
able to the weakest stomach. We re-
fer to Hagee's cordial of cod liver oil
with hypophosphites of lime and soda.
Eminent physicians pronounce it a tri-
umph in modern chemistry, and pre-
scribe it when cod liver oil treatment is
indicated. In our hands results with it
have been most satisfactory. — Massa-
chusetts Medical Journal.
CYSTOQBN.
In cystitis, prostatitis, urethritis,
pyo-nephrosis, pyelo-nephritis, gonor-
rhea, enlarged prostate of the aged and
stricture there is need of a reliable
germicidal drug for internal adminis-
tration. Cystogen serves to remove
in these cases the chief source of ag-
gravation, namely, the irritating prop-
erties of the urine, by stopping fermen-
tations and by holding the urates,
phosphates and oxalates in solution.
The administration of cystogen in 5
grain doses four times a day causes the
urine to become a solution of formal^
dehyde, capable of inhibiting pus,
staphylococci, streptococci and the
bacteria of the ammoniacal fermenta-
tion of urine, and of at least control-
ling the gonococci. - >
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THERE IS NO OTHER
reason for the conservative
scientific physicians' unqualified
endorsement and extensive
employment of
GRAY'S— TONIC
Comp.
than the simple fact of intrinsic
merit. It yields incomparable results
in general debility, ansmia, malnutrition
and nervous exhaustion.
THE PURDUE FREDERICK CO.,
No. 15 Murray Street, New York.
regarding the caoMtion of HAY FEVER, inclndinff Uric Add or
otfier depraved state of the system, Mlcro-OrKanisms in the air and
pollen from plants. Whatever theory is adopted and a systemic
treatment undertaken to correspond with it. it has been found that
lntelli|:ent local treatment is productive of freat benefit. 4| For this purpose a thoroufb
washing or douching of the nasal passages with a weak hot solution of TV««'s Aiati*
••ptic Po^nr^l^r has been found very beneficial. It cleanses the membrane of poisonous
secretions, soothes its irritability, and tones it up and strengthens it to resist further Invasion.
By frequent repetition as soon as any feeling of discomfort begins to return, the attack can be
greatly shortened and the patient made comparatively comforUble throughout its duration.
W^
Tyr«e*B Antiseptic Powd$r, /irtt intro-
duced /or treatment 0/ injlammation of
the vaqina^ has proved to possess
remarkable heating powers /or
Mucous Membranss,
tUi
For full literature
and sample, address
I J« S. Tjree
Chemist
j6
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a76
Therapeutic Suggestions
Gystogen is efficient in prophylaxis,
preceding and. succeeding operative
procedure in the genito-urinary tract.
IT IS A BAD HABIT
To whip up the waning physiologic
functions of elderly people with stry ch-
oline or alcohol ; after a short time the
deleterious reaction is more certain
than the primary stimulation. These
patients need help of a character not
furnished by a powerful stimulant —
their functions need gentle reinforce-
ment, and, ex{>erience proves, the best
agent for this purpose is Gray's glyc-
erine tonic.
The atonic digestive disturbances
almost constantly present in old age
are promptly overcome by the use of
Gray's tonic. It stimulates the enfee-
bled digestive glands to secrete abund-
ant supply of gastric juice. This in
turn assists the assimilation of food
and improves the general nutrition.
Then, too, these patients feel better
because the remedy acts as a prop to
the entire system ; they are less lan-
guid, are not so easily fatigued upon
exertion and are mentally more alert.
Many physicians report that the rou-
tine employment of Gray's tonic in
tiiose patients in whom are present the
signs and symptoms of old age imparts
a degree of comfort and well-being,
free from after-effects, not obtainable
from any other medication ; one phy-
sician states *<it picks them up and
holds them together."
Another strong reason for the use
of Gray's tonic in elderly people is
that it wards off the tendency to in-
flammations of the respiratory organs ;
thisf act has been noted and commented
upon for many years past, and is
doubtless due to the fortifying action
of the remedv upon the general con-
stitution and its specific innuience upon
the respiratory tract.
Experience shows that it is good
practice to administer Gray's tonic to
all patients in whom are noticeable the
symptoms due to advancing years. The
absolute freedom of the remedy from
depressing or other detrimental reac-
tion makes it the safest and most pre-
ferable means of combating the ex-
haustion and enfeeblement of age.
Daniel's cone. tr. passiflora incar-
nata is most valuable in paralysis due
to extreme nervousness. In severe
headaches during the menstruation
period, in nervousness bordering on
delirium tremens and for women suf-
fering from nervousness caused by
uterine troubles. In this product phy-
sicians have a desirable nerve sedative
and antispasmodic, which may be given
with the greatest advantage. In all
diseases of the nervous system passi-
flora controls the nerve forces.
OcALA, Florida, Sept. 5, 1903.
The Merz Capsule Co.,
Detroit, Mich.
Dear Sirs: — The sample of your
santal compound capsules sent me from
your house by request were given to a
patient with acute gonorrhea with the
most gratifying results.
I consider them fine.
Yours truly,
Jno. M. Thompson, M. D.
I have used neurilla, and deeqi it a
remedy of great value. Patieatt a hdy
of middle age, suffering from nenroas
prostration for past year. I tried sev-
eral remedies indicated in such caaes,
but with only temporary relief. She
would soon become extremely nervous
and irritable, and suffered greatly with
insomnia. I finally put her on tea-
spoonful doses of neurilla, and it
worked like a charm.
Rachael J. Eemball, M. D.
334 Virginia street, Buffalo, N. Y.
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278
Index,
A DIAQNOSTIC CHART OF TUMORS AND
PSBUDO TUMORS.
Battle & Co. have just received a
complete and unique chart on the above
subject, compiled by Dr. Edward C.
Hill from standard works on surgery
and pathology. The subject matter is
divided into solid neoplasma (sub-di-
vided into benign and malignant
growths) and true and false cysts.
The general characteristics of each di-
vision are given, and their twenty- four
classes, embracing over one hundred
varieties, are compared critically in
columns under the following headings :
Tissue, Topography, Number, Size,
Conformation, Color, Consistence, Mo-
bility, Sensibility, Surrounding Tis-
sues, Occurrence, History of Growth
and Miscellaneous Points. Features
of special differential value are empha-
sized by the use of italics. This chart
shows almost at a glance for ready
comparison all that could be learned
in a diagnostic way from the perusal of
hundreds of pages of ordinary text.
It stands, indeed, to such books as an
alias does to a gazetteer. This very
convenient and valuable compendium
is at the command gratis of any and
every practitioner of medicine who will
take the trouble of writing a postal
card to Battle* Co., 2001 Locust. St.,
St. Louis, and at the same time men-
tion the American Journal of Derma-
tology.
attention. You can spend a great deal
of monej^ on this class of preparations
if you wish to by paying for the water
that is with them, but Mr. Tyree is
selling only the powder, leaving you to
mis it with water and so make your
own solution. The powder itself sells
at a very low price. This merits your
attention. See advertisement in this
journal.
Chapabrin has proven to be a valu-
able remedy in the treatment of dan-
druff. It is a quick and permanent
cure when used in the following form:
Bl Chaparrin _ J }
Glycerine _ ^.3 ij
Myrica spirit q.s. J viij
M. Si^. — Apply once daily for a week, then
every third day for two weeks.
TYRBB'S ANTISBPTIC POWDER,
For leucorrhea, gonorrhea, gleet and
all such conditions, should have your
TANNOFORM IN INTERTRIGO.
Dr. S. E. Ostrowsky has employed
tannoform with excellent result in the
intertrigo of small children. The drug .
was used either as a dusting powder
mixed with an equal part of starch, or
as a 10-per-cent. ointment with vase-
line. When the latter is employed,
the inflamed area should be washed
with a solution of boric acid before
applying the salve. Forty infants
were treated in this manner, and the
most obstinate cases, which had re-
sisted all other applications, yielded
promptly to tannoform. The results
are ascribed to its astringei^t and anti-
septic properties. No irritation was
observed even in the youngest infants.
— Arch, of Pediatrics^ Vol. Xx, No. 9.
INDEX.
Original Articles paqk.
The New Light Cure. Bj Corydon Eugene Rosen,
M. D.. Seattle. WMhlngton 233
Syphilis Insontium. By Charles E. Caldwell. M. D..
Cincinnati. Ohio 236
Diagnostic Features of Small Pox. By George G.
Melvin. M. D... 239
Cancer of the Ftostate and the Selection of Gases
for Snprapubic Prostatectomy. By Reginald Har-
rison. P. R. C. S. 247
Segregation of Lepers. By 8. C. Martin, M. D., St.
Louis 257
A Plain Talk on Matters Pertaining to Genito-Uri-
nary Anatomy, Physiology and Diseases. By Dr.
Bransford Lewla, St. Louis 259
Original Articles. paok.
Some Oases of Hydrocele Cured by Iodine and Gar«
bolic Acid InfectionB. By J. C. Lake, M. D..
Ocilla. Georgia'. 202
Multiple Chancre in the Negro. By Luden Lofton,
A. B., Ph.D., M. D.. Emporia. Virginia 203
Causes of Impaired SexuaTVigor in t^e Male. By 0.
E. Boynton. M. D., Smithfldd. Utah 2es
Sublamlne in the Treatment of Parasitic Scalp Dis-
eases. By William 8. Gottheil, M. D 207"
New PlTBLICATIONS , 270
THERAPErTio Suggestions 274
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INDEX TO VOLUME VII.
OsieiNJLL Abtiolks. pagk.
Action of lodlpin on the Vaaonlar System. Bj Dr.
ElchardThausslg 42
Actinomycosis «nd X-ray Therapy. By M. L. Held-
Ingsfeld. M. D 47
Aene Simplex 222
Bacteria as an Etiologlc Factor in SUn and Genito-
urinary Diseases. By Dr. Gottfried Trantmann . . .210
Caosea of Impaired Sexnal Vigor in the Male. By G.
B. Boynton, M. D 265
Cancer of the Prostate and the Selection of Cases for
Snprapnbic Prostatectomy. By Keglnald Harrison.
P. R. C. 8.. ___... _..--.-.-_■ ___-. ....... ...^47
Clinical Remarks on Some Advanced Forms of Ure-
thral Stricture. By Reginald Harrison 16
Cntaneons Angiomata. By Symmers 82
Chronic Cystitis, Enlarged Prostate Complicated
With. By R Parries. M. D 134
Diverticula of the Male Bladder, Notes on. By Louis
K. Schmidt, M. D 13
Dermatological Teaching in Madrid. By A. RavogU,
• M.D. .rr .!? 187
Endovesicfd Surgery with Special Reference to Cys-
toscopy and Ureter Catheterism. By P. Krelssl,
M. D. : :. 18
Enicarin as an Antipruritic. By Max Relchmann,
M[. D,,... ... ......__.......--__.. . .- ........ 23
Elephantiasis In Japan. By A. S. Aahmead, M. D.... 58
Flagellation and Circumcision Among the Filipinos.
ByChas N. Barney. M. D 220
Genito-Urinary Anatomy. Physiology and Diseasea, A
Plain Talk on Matters Pertaining to. By Brans-
ford Lewis. M. D 201.259
Hydrocele: Its Cure by a Simple Operation. By R.
F.Licorish, M.D 190
In the Present Status of Bacteriology, Can Its Rela-
tion to Cutaneous Pathology be Definitely Defined?
(A symposium) 1 to 12
Koilonychia and Its Successful Treatment. By A. H.
Ohmann-Dumesnil. M. D 24
Median Perineal Urethrotomy and Cystotomy. By
W. G. Spencer. M.D 141
Multiple Chancre in the Xegro By Lueien Lofton.
A. B.. Ph. D., M. D ^ .263
Obioinal Abticlss. page
Pathogenesis and Treatment of Diabetes Mellitus.
By 8. C. Martin. M. D 33
Prurigo and Pruritis. By S. C. Martin. M. D 54
Pervert. A Sexual. By W. B. Parsons. M. D 71
Prostatic Hypertrophy from Every Surgical Stand-
point. (A symposium) , 93.132
Pemphigus Vegetans. By L. P. Hamburger. M. D...148
Prostitution in Japan. By A. 8. Ashmead. M. D 167
Prostatic Surgery. By B. M. Rickette. M. D 168
Prostitution in Japan By a C. Martin, Jr.. M. D...190
Prostatectomy, The Techmque of. By Nicholas Senn.
M.D 218
Relation of the Ureter to the Bladder. By Byron Rob-
inson. M. D 49
Segregation of Lepers. By S. C. Martin, M. D 257
Small-Pox. Diagnostic Features of. By George G.
Melvin. M.D 239
Sodid Position and Oceupation. By S. L. Eisner.
M.D - 72
Some Cases of Hydrocele Cured by Iodine and Car-
bolic Acid Injecttons. By J. C. Luke. M. D. 262
Spinal Anesthesia in Genito-Urbiary Surgery. By M.
Krotosxyner. M. D 74
Spermatorrhcea as a Disease Sul Generis. By J. A.
DeArmand, M. D i 164
Sublamine in the Treatment of Parasitic Scalp Dis-
eases. ByWmiam S. Gotthell. M.D 267
Syphilis of the Nervous System. By F. E. Coulter,
M.D : 170
Syphilis. Sublamine in the Treatment of. By M.
Friedlander. M. D 180
Syphilis, Third Act in the Drama of. By H. A. Rob-
Wns, M. D 55
Syphilis Insontlum. By Charles E. Caldwell. M. D...236
The New Light Cure By Cory don Eugene Rogers,
M.D „. 233
Urticaria: Its Vagaries and Treatment. By S. C. Mar-
Un, M. D 32
Varicocele, A Simple Remedy for the Cure of. By
Frank A. Brewer. M. D. 176
mf^ 13I^O:
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