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Full text of "Pharmacology Notes"









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PITTSBURG, CALI FORUM* 






INSTRUCTIONS 



1. To secure adequate patent rights is an im- 
portant purpose of this book. Only properly 
kept records will assure The Dow Chemical 
Company of such protection. When starting 
a project or experiment, write in precise lan- 
guage your purpose and general plan of pro- 
cedure. Record your work as you progress, 
giving sufficient details. Handwrite directly 
in the book. Do not make notes on loose 
paper to be copied later. 

2. All entries should be in permanent, black 
ink. Do not use pencil. 

3. The subject or title of the experiment and 
the book number should be accurately re- 
corded at the top of each page. The date 
should be recorded at the beginning of each 
day's work. Note all absences such as trips, 
vacation, illness, etc. 

4. The various acts or experiments completing 
one or more projects may be recorded exactly 
chronologically, thus possibly mixing refer- 
ences to one subject with those to another, or 
space may be reserved for the complete re- 
cording of one experiment in one place over 
several days, as you prefer. If the latter 
course is adopted, indicate at the start of the 
next experiment how many pages were re- 
served for the one before it. Give a complete 
accurate account of what you did and what 
resulted. Enterallresultsgood or bad. Incase 
of error draw a line through the incorrect 
words. Then continue with the correct word- 
ing. Copious descriptions with elaborate de- 
tails are preferable. Do not use private ab- 
breviations or Company nicknames without 
frequently denning what they mean. Always 
keep in mind the necessity of original data 
to prove any new discoveries. If any portion 
of a page of more than two lines is left blank 
when that page is finally completed, draw a 
diagonal line through the space and write 
your initials and the date on the line. If it is 
necessary to insert graphs, etc., in the book, 



attach the insert along one edge only and 
use the page under it in the usual manner. 

Names of witnesses who are present during 
the work should be recorded. Also the names 
of people with whom the work was discussed 
or to whom samples were given for analysis 
or testing. The dates of these acts should be 
recorded. It is also most desirable to keep 
a file of other papers relating to your work, 
e.g., analysis sheets, test request sheets, 
purchase orders, test results, etc., One or 
more scientifically trained witnesses should 
read and understand the pages covering each 
week's work and sign and date your book 
at least once a week. The witness form pro- 
vided in the book every twenty pages also 
should be filled in. The witnesses must not 
be those who are co-discoverers with you of 
any of the work recorded. 

New concepts, new solutions to problems and 
new ideas, plans or procedures and sketches 
should be recorded immediately in this book 
at the time they occur. When they are be- 
lieved to be patentably important or when 
experiments show results of possible pat- 
entable importance, they should be disclosed 
to and understood by your co-workers. The 
best possible proof of your discovery is to 
have someone who is scientifically trained 
repeat the work and record it in his own 
book. Whenever possible, have one of your 
co-workers repeat your work and note this 
fact in your book. In particular, when an 
experiment shows results of possible patent- 
able importance and especially when no wit- 
nesses were present, have someone else re- 
peat the experiment as promptly as possible. 

This notebook and all information recorded 
therein are the exclusive property of the 
Company. All contents are strictly confi- 
dential. You must take every precaution to 
safeguard this book against loss or damage 
by fire, water, etc. 



SCIENTIFIC BINDERY PRODUCTIONS 



CHICAGO S. ILL. 






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-IE DOW CHEMICAL COM PAN 

UNIVERSITY OF CALIFORNIA MEDICAL CENTER 

SAN FRANCISCO 22, CALIFORNIA 
5EARCH AND DEVELOPMENT LABORATORY 29 AugUSt 1962 



Doctor Sasha Shulgin 
Dow Chemical Company 
Walnut Creek, Calif. 

Dear Sasha: 

JAY & myself tried the MMDA on Sunday, 26 of August. 
Our log follows: (taken by (cAR£M up to 11:30) 

10:21* 100 mg orally 

10:55 felt reaction, saw slight green tinge in shadows 

of faces. Pupillary dilitation CC. No dilitation 
for W. L., but he felt "layback." 

11:05 Volluble, constant movement of hands & feet (as per 
usual for me) ¥. L. experienced the "floats." 

11:10 CC felt warmth & muscle "tone" (almost quivering) 

11:30 Departed for Marin country with U£>V 

(originator of tjjr Y v^S-) 1 Shopped in supermarket at 
about 0.8g. 

12:30 Arrived at home of WAIZTY <W Nj\ncy (Magnificent 

oriental stage in living room.) 

1:00 Picnic with no effect on taste. Still .8G, very pleasant 

2:00 Experience comparable to 20 MG LSD 25. 

2:30 Feeling relaxed, composed 

3:00 Back to normal; feeling of having taken amphetamine. 

3:30 Returned homej approx. .9g. 

U:30 Slight feeling of "green apples" in stomach 

9:00 Eyes still dialated; a little restless but slightly tired 

11:00 To sleep. Slept well. Awoke refreshed and happy. 

/W//Y q 



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THE DOW C-H-E-M-I-GA-fe— COM PAN ^y 

BOOK NO. 

Observations on. FsychoouuW £f foots of Methoxy "ethylene ,ioxy 

Amphetamine 



?vi^6 



\ 



11:20 a.m., Saturday, September 1, 1962 - 210 mg. MMDA orally 

TC MMDA tastes awful. The bitter alkaloid taste is followed by a 
5? distinctly chemical laboratory flavor as it' from old rubber tubin 
J This is easily dissipated by a drink cf fruit juice and cookies. 
J» othing ^eems Co happen for about kS minutes when rather suddenly 

an anvil seems to lower itself over -"our head; you feel disoriented, 
/ and tend to withdraw from socia t a little. In an hour you 
^ feel like wandering ofi into the hills e alone. This drug gives 
U» less feeling of being ill than mescaline. feet definitely 
•^ reaches a climax with a pleasant afterglow following. rarently 

there is no profound motor coordinati or ■• . Although I didn't 
^2 feel too steady, I could run down hill at full speed without falling. 
^ Would probably have trouble jugglinc thou 



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200 mg. yMDA yields that "Sunday afternoon" feeling of desiring to 
lie down and enjoy life; a luxurious feeling of "layback." 



No enhancement of colors in visual scene (except some greenish tinge 
in faces) but on closing eyes hallucinations appear to be quite 
real in 3-D; like watching a movie. hirst these dreams appear in 
black and white but later color starts a; In.-. Chartreuse and 
magenta first aopear, then blue and finally red. First had visions 






tinued on pa»re 2) 

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AL COMPffNT 
BOOK 



25 



larere numbers on garni 

brin ? oetween the a 

US „ 

Le down ana su , 3 t be 

he per s] 

heat - just a comfortable wt 
peac 

on. 
ful, 3D and a 

or a more e , enjoyin .elds rees 

more than beinp- in 



Commentary on e: 

f had a affed iave SWO rn it 

■"" »nta 

fuscia and chart 7her the re 

st Then marv ie trans 

sphere chartreuse, blue, .. icn cascaded 

down a gla 9g< 

There is 

the wor] I don't remember the 
time ago. 

visions. The Dig tendency is s . ck, not necessarll 

etely 






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THE DOW CHEMICAL COMPANY 

enjoy this feelJ oua lor.-or. 'i an: pre 

I feel just i incoherent, itly atoxic 

Here, 1 Ju ° ee ' ^pletely 

relaxed by 

and just 

with the world and ' h111 ' ' 

among the fields , U ' But t:;6n * littl6 

later Iwa lie down wit 

and visions. ' The euphonic 

state comes 

,ts start we, *els w 

the aals as tne "a 

I think •He-nt ™ ** 3ub - 

i » a 1 i 1 1 1 e 

mscious without goin 

feeling o i aall.atio 

feet were detached fr 

side; an illusion somewhat akin causing the 

light-, of a cigarette%ppear to detach ! 

f the c -tte when waved in a semi -Oar. 

Just now Loain- my eyes, ""! -'liant 

regal purple velvet encrusted w ie wnite 

back-round. The scene changes to a rid n effulgent light 

pervading every t !lo "' J toWe S 

However, he eyes, the cene becomes drenched in 
brilliant .b warmth usness pervaded me 

as the 



DOW CHEMICAL COM P, 



recently expert "pA^ 1 r ' iis me"< es te 

is riru Ld sell slaxan Lant. The ulysts 

shr it i fact it proves to be as 

Tie a conscious acious. It ^eems 

dreams a rfhile awak real appear!' 

scenes fill in the movies. 1 nave never felt rofoundly 

It fin -.' . ted 






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MMDA / MINIATURE HIGH 



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T use the word miniature in the spnse that I would describe 
a niece by the jazz nianlst Bud Powell 33 • miniature. 

Coir- j rinsr a c eethoven niano sonat* with Autumn in i*ew York 

■■ « " 

as ol-yed by Powell would, be an^lagous to com~«r^ng attMl and 

/to M 

â– tLoa oilijno . MN!DA domes through as a miniature hirh -- everything 

is there but in lesser quantity and duration. 

VVDA s tors barely short of the Olvmnian Universe of tiire- 
ceasing and organic and inorganic rad'apces ». i'he immediate ^art 
of the hlflji Is about two and ^ne hnlf hour? in duration, Hather 
than a cessation of Time, as there is with m^sclin or rsilocvbln, 
there is a kind of time! a ssn-ss during the first m l^iselike 
hour of the high. There is morn <?£>a feeling of stur>pf act ion 
than th»re is with most highs. 

In a car climbing theJBerk°ley foothills I went into a ter- 
rible fear, *-/•'•', €ne i^iphti Vor-at •^l&f&.S'pdA.'s It only lasted a few 
minutes -- but it did not matter in the tlmeles«ne ss how long 
the nanic lasted A it was eternal. I looked out onto the grassy 
hillside at the dead silver-brown grass, in the exnanse of field 
I could se- each separate blade of grass gleaming K±±bi and the 



THE DOW CHEMICAL COMPANY 

trillions of brown-silver blades blended together into a vast 

wavering fur. *'' ar below was the nanorama of foggy Berkeley and 

Oakland and the bay. --It all began to loom 5n tlmeles^nesa 

and beauty. --1 thought I was going to °nt. a r the Olympian 

Universe. I WAS NOT P EPARiD FOR rr ' T : - OLYMPIAN \WA I --I 

had been expecting something like mari.1uana A 1 realized that 

if I sneered the Olympian that I hadn't yet recovered aufflc- 

ientlyjfrom my last high to hold myself together. 

Heat swelled in my genitals and rose to my stomach. --I 

felt ^Uv agonizing ££$■ ^FgfyfB&f 3 ar . I wanted to a* the others 

to go back so 1 could rake thorazine. i couldn't talk. The car 

swerved around a hair in oend in the road giving me another 

view o^ the silverbrown g^ass-fur and the vast unwar ted dearness 

of the ?>w. 

Suddenly I was fighting with 'Obtain Zero 1 -- I mean the 

whole disor^ ~ed and et or, ni ty-se^king consciousness that is no 

longer mammalian in mature but belongs to the order of molecules 

and in^rt matter 1 . I decided th - 1 a 1 1 i could do wasto go with it 

-- to let ^ero take over, put then 1 was su'-e that T would not 

come back. *iian I tried to hold back the high but 4^ realized 

I would do mvself dcjnage that way. Then I tried to get on top 

of the whole high and control it. -ill in all. I tried perhaps 

iJ., y L -v- almost 

fifteen or twenty mx*m±±*1mxxm± unrecnllable -aori undescrioabl* 

means to /Jdih4^ control or escane the high. 

Ehirnlgfe this time I believed that I was goine to nieces 

and I would possibly never be with the human-world again. V? 

insides were eoing wild and my conscious mind s^em~d to be the 

only force ho ding me together. At one ooint I managed to ask 



29 



30 



how the 'oaaj J b oo n figured. --I was "°as°n"^d by com aring 

- dosage to masculine dosage - ; ro? a moment I grasned the fact 
that I could go through three hours of the f -ar . ±hen my insides 
and mind vent wilder. o esus y I could not ^nt^r Olvmnia again'. '. 

When the car sto "ed I was in co.^rol and the aroused mol- 
ecular consciousness had dis~i aced. ihe number of exits and 
■ratiKRJt ordinary animal no.ers that I {*£& tried had giv^n me con- 
trol, l account the sudden g ng of ?ur^n-s? to »4de ex- 
neri nc^ with p(jy lucinog^r.s . 1 don't think my of the methods 
that I tried worked -- b\it the number of ooss ioilitles pave me 
an as'urflno" i^st I could control me even in Olyirria. 

1 told the others what had ha rened fc ftinv and felt I could 
-n.loy somo rf ; h* day. ' '» « ' ' ' ' ' ' ' f I 



/ 



In - ^r^stinsly , none of th ,j oth^r oart ici-ants got tc the 



Olvmrian Universe iurine the hitfh. I accent th^ fact that I 



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touched ^pf^os^am && 

- 

{LvJ . v i»ii.-^>- wpeyote and osllocybin. 

As wp w". k r -d ijc the fr tcath ov°r ffolden brown dust I saw 
ftfttls footprints of birds, tennis* sho Q s, and bare feet. The 
frightening nature of tracks and artifacts beirar to quchxxjiIixji 
ov°rwh^lm me. \3 T walked T tri d to insulate myself from the 
sipbt. To my right wasthe d^eam ranor .ma of hundreds of smare 
mil-s of enchanted cities and dr- mreality fog "ouring uoon 
th-m from the hay. 1 wisnot interested and oniv cared about 
k^oinp- myself together and not slicing back to m et Captain 

Z^ro . 

The dnort, et-rnal. urhill walk exhausted us nnd we fell 
on the ground in a tiny stand of tr es . I still wanted the ex- 



â– THt-DOW- C 



i end and return to the me nines 






and realMies.^6% I had adjusted enough to make it through 

the high. My companions closed -ye 3 and t having brain 

my eyes 

movies, (^arlier sqoquu had b ^n forced shut many times oy 



hied mv ?yes o"»m 



3 o, \np stark reality exactly <s I sa> it 

t. S ^.4 



the -u'horlc hallucinogen :'â–  asure.) Now 

not wanting in movies or visions. '.Yhen I clos d ny s ex- 

perimentally I saw on] y .s and -inp blackness. 

We talked desu^.tor and dozefully and I real iz~-d that 

I was aMe to s- a through the 'yes o r my corrnanions . Th p y were 

. I talk 

r^&bO Vrft ^\s-\1\Lf*^0f I found t Iking too 

' t . V.y toe: ion 

and r ~e. 

Vh=n I icaret 4 «s 1 c Lnd ray lira well and they 

were numbed. Matches kent ut in a wind that was not 

strong enough to blow them out. '/<e wobbled when we walked. 

We stayed in tl ° sand of tr oo s . I sat for a wrile 

then got u* and sat ir nother Dlac°. "Then I got u^ again & etc. 
8 Exc nt for visual sensation, which w*s lust ^n the verge 

of mescaline or "silocy In vision in c ' a ri ry , I d to be 

se°l d from sensation and living In a kind of hyner-lucidity of 
sense -- a 3 ant paradox. 

I 1 ay iack and closed my eyes and Jtis d raising the 

goddess Kundal ini ( x he Se"^nt Power) from the base chakr a t â–  
through mv nody. I XMMJUUtix±xxmm.m.m.dni succ- ed"d in raising the 
Dower, for the first time, past my shoulders and into my head. 
I r^aliz^d, as I did it, that I was not truly raising the! Seroent 
Power but rather cleaning the nerve tubes. However, I achieved 



32 



THE DOW CHEMICAL COMPANY 

BOOK NO. 



SUBJECT 



DATE 



-1 1 — i 1 1 1 — i 1 1 — i r 



gr^ylsh-clear affective nictures ' "3. 



It was a g^od feeling. 

The crystal clear air gave bright gr^en sharnness to th" 
ev=rgr«°ne. Look Tig at tr-es of leaves or olants whs like a 
mild mescaline high. Fir tr es b»cam-- living, gr°»n, modern 
3ci)lDtur°s o f ' strange Indian rococo blasts -- is If th sculotor 
Linschitz worked at th e ir trimming. 

Th" malals'llke feeling b°pn to "nd tic 5 the dozeful feeling 

/ w i th it. 






I walked to a r°dw-nd corse wh°re oth"r members of th* 1 narty 
were sitting. I was struck by th" absolute and superb fcraix 
beauty and clarity o :' the peonle and the trees and air and the 
music that played over the por' .ble ^adlo. I felt close to the 
children and admired their beauty, fct this noint I realized 
that 1 was sim-ly sitting and n joying a Sunday noon tXx in 
its*~t\)ll nle-.s ntness. Ordinarily I would nave been bored with 
out more to do. r he next couc 1 - of ho rs became a pleasant and ^ 
beautiful nicnic. x he come-down was abru-t but «*t unr 1 "asant . ■***<*, 
^ime mssed with swift rapidity for the rest of theday. Two 
hour -eriods would flash by. Lat.p -hat night I was kept from 
glPPt) ^nr half an hour by brain movies — 11 ' tie crocodiles 
running across dusty roads through spotlights in the da-kness, * 
magic eve~gre"n tr"es fading into and out of u*±±? reality, 
and «juut±ata*xx anecdotal sequel 























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J. 



THE DOW CHEMICA 



AH rE 

A w<v-k after raking VWDk I woke in the middle of the night 
and as I awakened I felt that there wo^ld be no reality but 
only nothingness. I was horrified and threw myself bolt upright 
in bed and opened my c yes instantaneo\isiy . 
8helley says: 

Lift not the painted veil which those who live 

call Life* though unreal shapes be pictured there. 

"T 
y|nd *i&v but mimic all we would Del ieve 

with colors idly soreadybehind lurk Pear 

^nd Hops .t3rin 0estinies» who ever weave 

"Their shadows oer the chasm sightless and drear. . • 

The awakening I had was definitely a reaction to the WMDA. 
Yesterday I talked with a man who has tak^n too much lsd. I tried 
to avoid son king 01 hallucino ens but h^ wts insistent. As 
I described sotp post-In llucinogen states of extr me anxiety 
regarding the nature of reality, the man began to writhe in his 
chair, wring his handstand io»^ the abllitv to speak»£e*idD»lr^ 
J&frt I have be<n in that state. While sneaking with. R-^_ 
he identified it as an anxiety state and pointed o\it that it is 
not only related to hallucinogens ut is a not uncorrron anxiety 
state for those who haveinot had drugs. 

•■o 0,, accounts the state to an arising of «6»conscious 

material to the surface. 









at s<=- ms f 'lTiA and *hat 

1s ' ring as hit er, What it d -)<- 3 ri C'a the 

intuitions that T hav° that strengthen and contradict °*ch ot-er. 
I am awa^' of two f^ lings: ftV.at the 'material ' is of a r°nr«s°ed 
psychological nature in th e Fr^u^ ian-Reichian sense, and that 
ther c is also another order of'mate-ial' confront ~d. The other 
or^^r is that of the molecular lev~l of consciousness. I mean 
a nart of ourselves more related to th» philosophical k*ju«±*m« 
consciousness of s«a urchins arid sronees -- who are no mere than 
the tugs of th°ir desires arid hungers and rhe consci nsn-sses 
of their motions and withdrawals -- who ar= an actual conscious 
oart cf the -dnvsical universe and th° actual b^injr of their 
oro^oolasm in the 'Surge of Life. 1 It would e inter es'ing if 
what we so surelv call the - ftubcnsc d . '- M o o-p . Uncoaacious were 
in reality two or mor e vastly divided ~art«v r b^inp that 

a^e both comironly unacn^.-si le. 

I am not sayir.ff this to strnah'n mv argument uhat I con- 
fronted th" molecular consciousness on N'VD.i. I was in too much 
of a fear state to be definite of anvthing »hen I think of it 
now t w w^eks later. 

-- But I am intuitively sxxJtfcliB sure that 
we are m-eting two unknown areas -- both repressions and a 
n«ijicMJttr m ^lecular-DhilosoT hical-UniverseconcioMsness , I v ave 
a st^ons fe = llng that vh a second of t v iese should b<=" left untouched 
by both psychiatry and happy-day inves t lea t l^ns . <Ve mess with 
som« strucure that should remain unknown -- Unless the experiment- 
er is a*are of *h P risk -- or ?o^' 9& slo'viv in an investigatory 
manner with r|^ caution. 







THE DOW CHEMICAL COMPANY 

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BOOK NO. 



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THE DOW CHEMICAL CO 



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BOOK NO. 



SUBJECT 



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-IE HOW CHEMICAL COMP. 

Chronology, of Intoxication and Description of Effects vtJL^ Qj? lOS^ 

All times in the following are stated as times from the first 
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Chronology of Intoxication and Description of Effects 






All times in the following are stated as times from the first 
ingestion. Observers' notes have been interwoven when appropriate. 

0:00 



Ingestion of 12. 5 mg (as hydrochloride) or 140 (j.g/Kg as the free 
base. (There had been no food consumed during the previous 12 
hours. ) 

1:00 



Ingestion of a second 12. 5 mg. (TMA-2 has a very slight 
alkaloid-like bitter taste - neither unpleasant nor lingering.) 

1:20 



Pupils show slight dilation, light muscular tremor, initial nausea, 
and an onset of diarrhea. 



1:30 

Cholinergic effects moderately severe. Teeth are chattering and 
vibrate when rubbed together. Pulse 80. 

1:40 



Only a moderately severe nausea is left. As has been observed 
with LSD-25 intoxication, the symptoms of nausea are complete, 

except for the desire to vomit. This phase receded over the 
following 20 minutes. Pulse unchanged. 

2:00 to 3:15 



During this hour, the complete syndrome, except for intense color 
effects, of severe mescaline intoxication developed. There was 
essentially no nausea, and the world was filled with distorted, 
moving things, all quite humorous. Peoples' faces were grossly 
distorted, and there was very little thought or worry of personal 
safety. Muscular coordination quite good. Time passed slowly. 
Conversation both coherent and clear. 

3: 15 to 4:30 



At about 3: 15 the first indications of still further mental and 
physical capitulation to the drug became evident. A numbness of 
the fifth, and part of the fourth, finger of the left hand was 
frightening, and the recovery of this "asleepness" constituted a 
mechanism of preventing further inundation. Compulsive massage 
controlled this physical dissociation although asleepness of the 



56 






THE DOW CHEMICAL COMPANY 

-BOOK NO. 
BJECT 

knees, muscular and abdominal cramping also began to occur. In 
cycles there would be periods of relative simplicity followed by 
periods pf nausea which could be relieved in part by attempted (but 
unsuccessful) vomiting. 

Simultaneously with the physical cycling occurred a mental, intellectual 
occulation that, fortunately, possessed a different period. From 
the beginning of this hyper-mescaline stage (about 3:30), waves of 
near-unconsciousness occurred. The hallucinatory motion-of-real- 
objects became unavoidable and overpowering. Periodically, at the 
crests of cycles, an impression of fainting would occur, and it was 
felt certain that to lose the thread of return would mean never to 
recover mental integrity. 

Fortunately times of mental and physical stresses did not correspond. 
Subjective time was badly distorted. A short visit to a dark room 
was unbearable due to the active and frightening hallucinations. 

4:30 to 5:35 

At about 4:30 a return to a recognizable "mescaline-intoxication' 
was the first believable indication that there would be an eventual 
recovery. A drive through the countryside proved to be extremely 
humorous and enjoyable, comparable to peak effect at about 500 mg 
mescaline. 

5:50 

Rapid recovery from the above effect. Increasing periods of 
lucidity. Completely unable to eat anything. 

7:00 







Able to drive a car without misadventure. A mild stomach ache 
was the only remaining physical symptom. Occasional touches of 
unreality did still occur but were completely controllable. 

12:00 



No remaining effects. Appetite good. Sleep normal. 
Conclusions 

This drug, TMA-2, has an apparent potency of 20 to 25 times 
that of mescaline, and of perhaps 10 times' that of its structural 
isomer, 3, 4, 5-trimethoxyamphetamine . If more complete studies 
show no increased toxicity for TMA-2 (all amphetamines so far 
have been similar to one-another) , the improved therapeutic index 
(x20) would warrant the consideration of this chemical as a substitute 
for mescaline in psychotherapy and in clinical uses. 






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DATE 

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<& H H D A 



may 31 eclipse day-1965 

drugs were taken at 11:30 for \Lo2^ 10 ° mg V?l5k 15 LSD and later 40 ritalin 

may 30 V?\sh took MMDA loo mg while I had harmalinefl this report concerns ^iJX,' > 

mmda 'lifSfiitiTf" 

It seemed to take 45 minutes to work and then came on very suddenly and 'hit 'me 

almost like a blow on the head;as if my eyebjalls were being pulled out and my whole 

head expending; Soon a COLD feeling set in and shivvering;this was not unpleasant 

but was in marked contrast to the Ritalin which gave a warm feeling of activity and 

verbalization entirely different that this 

The cold was as if I was in carbonated water(tis occurred as I was having the vision 

of a carbanated pool of water or nearly at the same time in retrospect) 

there was no anxiety ;then the lite seemed to dim in the room-this a retinal phen&m 

or having to do with the eclipse? in the pacific at about 3 pm; 

My state in about 2 hrs seemed to be one of empathy and passivity ,compassion of an 

impersonal sort;the music sounded artificial and canned and tinny in contrast to 

the voices which sounded rich full and finely precisely articulated and melodious 

Also I had the impression there was a lotof stuff in my head I was not talking 
about; 

Later when left alone the hallucinations occurred ;as clear as any I have had on ot> p 
hallucinogens ; ( c ) 

these were not kaleido scopic or assembly line or oriental patterns ,but life like 
with vast open spaces(typical of her paintings and essence person patterns )with 
people moving slowly and liesurly much realism; I could conjure up monsters when asked 
but these had an artificial quality-they were eating something; 
other visions of much food preparation and skinning and prepareing of annimal 
skind. drying scraping etc;many wild flowers and WIND- streams which were already 
part of the ocean;I regertted its wearing off;it did so very slowly;I was in a 
paradise concerned with externals and conforming to the structure we had set up and 
perfectly satisfied to be all available and all out there with youjthe internal 
things and hallucin later were interesting but the real^vi ness and n ness?not 
nearness i think — of reality was very gratifying ;a similar outerness with ritalin 
but it was more warm and dramatic nat so etherial; 

no profound philos thoughts but direct sensations which started with physical then 
emotional;no thoughts or judgements of people or things ;no facial distortions(she gets 
visaal and auditory hallucin-sounds of water running, creating 'music' of squeeks etc) 
POSSIBLE USES 

good for one with a lot of anxiety which shuts him off from experience ;those who are full 
of "I like, or "I dont like" they are so preoccupied that they dont see the things 
out there that are really going on, but project and shut off etc. I had a detached feeling 
while the ritalin seemed more personal and closely empathetic;sort of chummy and talky 
and pink tissue, /mmda was more like clear mountain air 

with lsd my thoughts go sircularly,i get cought up in flippant philos ideation 
brain storms almost a mental masturbation 

I was so preoccupied by Ko^ s andwers to my questions that(with ritalin) the images 
thev caused in my mind caused me to be almost physically removed;feel this way 
Kft"Z_ see^d "to 'work' to overcome the passivity this dmmda induced 






Reoort of JAY on /mmda 6/2/65 i «**?>». a. // / • 

about 1/2 dosage 

I found this drug not at all like any other ;in the first place there were no 

appreciable distortions hallucinations or eyes closed imagry ;second the mind 

was quiet ;no words explanations comments theorys and rational thought subsided; third I 

was fully aware in present time especially during the forst few hours 

fourth; despite the seeming short action of the substance there is a time disorientation 

which lasts over six hours which undermines ones judgement in driving a car;so at least 12 

hours should elapse before drining is undertaken; 

in use of 02-C02 to potentiate the action of the drug there was a most remarkable effect 
As though a floor of some sort was dropped frmm beneath me and yet I was still supported 
and with this floor dropped a general feeling of anxiety of a free floatiDg type 
which has been plagueing me for several months; later on a half hour or so later ;when I 
was i explor^nig the area newely empth of anxiety I felt it again for a few moments 
and then it dropped away for good;I was completely without tention or pressure 
of any sort;I expect that the effects are similar to that of a tranquilizer or an 
ophiate( although I have experienced neither) except that there has been a long term 
change as a result; 



J.IMDA J'AY co2 and o2 used to set it off 

I felt as if a floor of some sorb dropped from beneath me and yet I was 

still supported ;v/ith this flood dropped a sens of free floating anxiety 

v/hich had been plagueing me for several months 

30 min later 

when I was exploreing the area newly empty of nnxiety I felt it again for a 

few minutes and then it dropped away for good aid I was completely without 

tension or pressure of a ny sort; like being tranquillized or morphine 

but ive never taken either j there has been a long term ohange as a result 

6/2/65 

this drug was like none I have ever taken; no hallucin noted and no 
distortions of what I looked at (I aggree with the lack of distortion of 
outer objects or faces) 

second; the mind was quiet no words explanations comments theories or ration! 
thoughts ... 

fully aware in the present tim© especially in the first 3 hours 
there is a time distortion ;6 hours' later WHICH UNDERMINES ONES 'JUDGEMENT IN 
DRIVING 

i misjudged the traffic, lites duration etc 



THE DOW CHEMICAL COMPANY 



MMDA reports 



#1 49 yr old male; set relaxed to very slight anxiety over personal emotional 

matters. SETTING! De Martin be a ch off Falce-klamath rock 8/29/65 11:45 AM 

11:45 150 mg _ 

12:00 slight nausea and methedrine/ritalin like effects 

The 3 of us are at the falce river mouth drying seaweed . on split redwood 

> r he fire burning preparatory to cooking the rock cr a b just caught takes on 

a fantastic appear a nce 

12:10 I withdraw ,the talk of the others is too much; she puts on sunburn oil ' 

WOW 

12:15 the tiny fairy feet of the flies slight cramp like slight nausea and 

my visual field starts lighting up 

12:20 some vertigo and heaviness and time streches outjnumbness in the chest 

as when an opiate is taken; 

Still study geometric patterns; excess lite on closed lids interfers with 

(retinal ) visualization, vertigo only with eyes open 

dance of the glittering diamond studded sea waves; increasing motion and beauty 

No t a ste,just passive introversion with l a rge time lag 

12:30 people appear on the beach and talk to my oompanions;I have no par a noia 

this surprises me; 

12:35 trembling after images are very brite and last long; I see a long 

corridor and faces upside doun 3D corridors that bend and recieve me 

basket likew with visions at the bottom; 

the m a n will drive and the woman provide; two beauties and or a b 
thirsty a nd mouth slightly dry; much less than with rit a lin or LSD etc 
green to rose after image 

NEED A SEMI SLEEP STATE FOR NEUROTICS /FLUS THIS DRIG /so they can let go to 
Its effects better 

Increasing landscapes appear inside; inw a rdly I told her of her beauty and 
the outward she also responded by looking up at me. 
(this is a good introductory drug to the drugs of this class) 
to become familiar with the drug state in as gentle as possible a fashion 
L a ter; ± see my mother In animated conversation with another woman 
this w a s at 1:30 

12:50 to give self res and to cut off the trash and 'worry' so as to enter 

the semi dream state where you are protected; not as noisy(many) dreams 

?as in live? or more? 

music or sea 

as a structured backdrop against which to go in 

bold kneeded wrestler geni probably on waves Like LSD nook Darred woman 

sits up m a n upside doun facD; fabuluous kiss bitter crab and people 

million fingered dance of the sea; green apple crunch 

I hallucnnate lists hungarian rapsody 

aid then waltzes 

then see at 1:30 my mother as above. 

Remarks: this substance seems to have a much genteler action than others 
of this class jperhaps more like Cannahis or psylocybine; there is little 

paranoia reported by anyone ii^w ^fi» 

I noted the hallucinations of two types :one, those which were strictly rotia 
retinal and more minute and small and Influenced by lite and evoked by foe* 
using' on the 'lite' ahead on the retina or lids, and the other those deeper 
in the visual tract end occiput which are larger and more global dream like 
end when solid are quite dramatic and unforgettable as in meditation. 
There is less adrenergic or alerting effect per hallucinatory unit of this 
drug as well ; 



JOW CHEMICAL COMPANY 

REPORT ON MMDA TAKEN September 5, 1965 

Since in my walwus type floundering about since then, l*ve managed to lose all 
notes made at the time, I'll try to do it by recall and then will undoubtedly find 
them. 

Drug produced light nausea and slight dizziness within about kS minutes and 
shortly after began to feel "psychedelic" effect. For awhile felt like mild dose 
LSD with slight disorientation and visual imagry at closing eyes. Imagry wasn't the 
vivid, shapp-colors type however, but like a kalaidescope filled with pastel colored 
smoke. Reminded me of a gadget seen in New York museum of modern art in which con= 
stantly changing swirling colors were projected on a screeen. Every now and then 
across this field floated an unidentifiable black shape/blob. Overall general effect 
sort of like Rorschach ink blots. 

Within an hour I felt my mind snap into advanced gear and attention focus like 
a lasar beam. Felt I KNEW what I was about and was thinking with unusual confidence 
and clarity. Total focus on fs£iL altho my response to him was less involved 
emotionally than it usually is in sessions. Was unable to cry for him or for self 
yet felt no hostility towards him or fear--just intellectual sort of endeavor and de- 
sire to do something effectual and positive. Was unable to account for some of his 
behavior and was very curious as to what diagnostic lables it would earn. Had an 
excess of energy and large overest imat ion of own strength-felt fully confident that 
I could hold down my Ifialf of Ncli- with no trouble until I recalled that this wouldn't 
be my normal realistic appraisal and then began to force a bit more caution. Could 
la feel my own emotional state being blocked as almost with a physical barrier - knew 
there was great upset underneath and that it would leak out as drug wore off but was 
unable to feel it totally. 

Time sense was slowed-kept looking at my watch and thinking more time must h< 'e 
passed than actually had, but wasn't disturbed by this. WhenfOGiu began walking a <und 
expounding his revelations I bacame restless - began wondering, wanting information and 
activity. I realized that ai long as there was active action I could focus entirely on 
outside and was find, but when things slowed down feelings of self coming back were 
distressing and I was stuck back with me and pain over JA\ Tried to turn it to 
interest in and learning about N£iu and about the total situation buc kept wavering in 
attention between him and myself. B? By about 2 pm was ready to start on ME<u again, 
trying to get him to come down and sort of cut off. He was unable and I took it as sort 
of a challenge. Q.u£ seemed unwilling to direct Hiim strongly and ! finally played on his 
need to "help" me by giving me an hour with vSlVe It worked. Put on the saddest music 
I could in order to dredge up hurt over JAY and whatever it represents but altho tears 
were tjjere, it was all dampened and toned down. Knew I was very upset but that knowledge 
was more upsetting than the upset I knew was there. 

Went out to the pool when $oltf : 6 R - and PSC-rC'l came . MlSlu was all shaken, pains in chest, 
unable to breath, felt nausea and choking sensations. Was marching up and down, back and 
forth like ward patient in a yard. Was disturbed by this and went to tune the guitar on 
the piano wi th C-jt-Mfy . Felt £}Z- being annoyed by me in house and by my playing wi th^tAPfS 
and knew I'd have felt hurt if it weren't for dampener of drug. (JcADY/S tuned the guitar and 
I went out to see what I could do with w£|L • We talked awhile and I found myself ablfc to 
play that guitar like never before - was elated and entranced with my own music and new 
abi 1 i ty. . .especial ly since I found I could work withNfSlL. and play along at the same time, 
using it for sort of background and emphasis and attention changer. Talked to H£^ about 
pains in chest - had him try Gestalt exercises but he was too far out. I felt him as a 
little boy asking mama to fix it and I felt like i 'd like to be able to fix it, but not 
inddequate because I couldn't do so. 



c*J0GJ 




THE DOW CHEMICAL COMPANY 



CtU^o^S came down, wanting attention and to sing and play the guitar. I was happy to 
see him and we began to sing a song but (5>"Z- tore out and jerked him away like a shot/ 
I understood how she felt and her worry about his contamination, but I felt resentful at 
being considered a contaminating agent so decided it must be pA-JL she was worried about 
and rationalized it that way. 

Spent time talking tofgtftfV about her feelings since separation f rom $ufciri£R. and 
watching her way with her child. All along was playing one song after another and 
my attention was sort of spl i t . ?&6£rf ;ame on strong about dislike forSuWSR. but didn't 
realize she was saying it and by way of attonment m immediately began telling me a' ut 
how neurotically she operates - but i n • t*F£ — ' s terms and sounding like a parrot. , tried 
to be subtte and gently get her to see what she'd done, but it somehow didn't seem improtant 
compared to fAo'U wandering around painfully and looking at me like a sick puppy. So ?no\- 
and I talked about the things that made him nauseous and he went and leaned over the fence w 
a few things but explained that while these things would have upset him six months ago, 
they don't any more. Things such as "penis" and "breast" and "hand" and "hang". 
,1 wonder if his mother hanged herself} I gegan trying to play Tom Dooley and noticed 
'AcfU swallowing hard when I got to "rnis time tomorrow weckon where l"ll be. Down in 
a lonesome canyon, hanging from a white oak tree" Also on "Poor boy you're bound to die" 
Began to worry that there was more going on than I was hep to and quit immediately. 



^wes^K- came and ^&a\ left. Felt warm even toward S^EPS.^. - allowed him to play big 
brother thing with me wh.ich is his wewest button to push. He showed me things on the 
guitar and I 4jave it to him and began playing with J"AV . Not i ced VA^u- watching me 
play withiX/vV with tears in his eyes - he kept looking away. Felt some sort of vi- 
brations emanating f rom r"A JL - - like he was silently begging, pleading, entreating me 
for something. Didn't know exactly what I could produce that would provide it. He 
was hungry and wanted a pear - i told him to pick a peach instead. He did, showed it 
to me like a little kid and ate it like one, leaving most of it all over his face. So 
I put ^AV on^vitf^'s lap and began singing nursury rhymes. Pawl_ came and finally sat 
down but with that damn shit eating grin on his face. I didn t know what to make of it 
so d idn ' t . 

Physical effect of drug most outstanding. Full of energy and coordination. Lost 
fumbling, clumsey feeling altho I did manage to whack my shin on the water pipe and trip 
in a hole twice. But that's par for any course. Knew this was the same stuff j>V had 
and kept wondering why I wasn^t getting the same euphoric, limp happy eeaction. It was 
a physical and psychic energizer for me but without the emotion emphasizing effects of 
dexadrine. Went home and to sleep with 3 pills finally at 2 am. Kept self curling in 
sleeping bag womb all next day and night and didn't want to come,, to face the world on 
Tuesday. It isn't a nice world these aela days and it deteriorates steadily. 






I have read pages 



notebook atncl unTl 

There are im 



to in thi 

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po THE DOW CHEMICAL COMPANY 

BOOK NO. 
SUBJECT 



tient is a 58 f* old aale 225 Kg a taken 
I had a stran je of ray h-ndo to about 20 minutes; not a fecli. 

so riuch as just that 1 was attracted to them soothe* 
i • few minutes Z began to get fo rful-of V lcnlincoo of the acute 
orience of olononess.I did not want to go in. 

I laid face doun (often a depressed position for iae)Iiext I remember I 
»tal tag to the kids at school (an image) or to ether teachers; this v/as 
Very vivid; the sceens at school were BBsre vivid than tnose in .ho office 

ore 1 actually . . I people more real than YOU.I tried to'come b-ck' 

by getti hysically close to foU.but still drifted off to sc.:ool 

I was very sleepy throughout (not the lortinc effect of L I ) 

rour tours later went immediately to sleep (I never did with L ) 
I vas bothered by the tte}ity of reproduction of MSie fro 

nutes after dru kon-t o crouded small office bothered me 

at first 

of any experience I avo ha4 tis Was most like a serios of -ire. 
ly remembered (this dru- is most sought after by our helpers in drug 
ork- r fundi n best on it as he others)! felt after it v:as 

over d after a lor •■ ~' J - oxm to bod and 

i a series of dream li itates very vivid and colorful :md re 1 












L 5 






THE DOW CH 



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CWrs ; 

here • 'ts verfcr brief beaaus re is little to 

co â– â– .. y keep as I have another 

please jee that K^z. be one of these copies and I gues iha is 

sting so he should have the other onej 

(££> 190 ttsgfto ng 

an experienced person ir he an f drugs: 

conplete neurological done 1 hr prior to testnig pletely neg»c-.:.re 

fu • for was nysta mus-he ol nys in extremes 

of lateral gaze»l£t hra after t ? -js drug he • t ^owt the a nount 

ar kiioe of the neurol te 10 dlJ of 

hra er 

his b b 14 /90 to start was ur ;ed 

he only icneed a bit of tingling in his arms and leg! and a B i 

sense that hla LI ,thio was not objectively confirmed 

during the nourol testl 
he had no hallucin etc 



<£££> 



ect \ r o is s ivo to a 'h as 8 mcgm of 3 de 

f lie ' — within i of inje t.ion of 20 rag of 

a sense of tentlon Ir bhe chest not tinpleas z nt»l Lty 

t- *ct with •ome eryin a • ' ->te tr the oeeaeion« The enlarge 

third dl Lonality of enisle and slight unsteadiness i lo comet - iso 

usual ; - - »rt and eiti draw . 

t ese effects seemed to be the equivalent ef bout lo to 15 ... 
and lasted v or " hour* wit) the pea : at l.' to g hours. 



11 be publishin taper with H£A:££Y on vitalin and LS end 002 gas soon 

â–ºt my part of it writt n 






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DATE 



141 



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