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Full text of "Subject index of current research grants and contracts administered by the National Heart, Lung and Blood Institute"




^,G Subject Index 

t^^^°^ of 

durrent Research Grants and Contracts 

Administered by 



ao^^ 



The Nationa! 

Hearty 
Lung, a 



Institute 



Mff/ 2 4 1979 






HftLL 



p^osrro^^ 






December 1978 



U S DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE 
Public Health Service National Institutes of Health 



This information has been assembled for 
use by NHLBI staff and the National 
Heart, Lung, and Blood Advisory Council. 
Questions regarding any of this information 
should be directed to the Information 
Systems Branch— OPPE-NHLBI. 



J 



1 



DISCRIMINATION PROHIBITED: Under provisions of applicable 
public laws enacted by Congress since 1964, no person in the 
United States shall, on the ground of race, color, national origin, sex 
or handicap, be excluded from participation in, be denied the benefits 
of, or be subjected to discrimination under any program or activity 
receiving Federal financial assistance. In addition, Executive Order 
1 1 141 prohibits discrimination on the basis of age by contractors and 
subcontractors in the performance of Federal contracts. Therefore, 
the National Heart, Lung, and Blood Institute must be operated 
in compliance with these laws and executive order. 



p^ew^o 






i^u- 



Subject Index 

of 
Current Research Grants and Contracts 

Administered by 



The National 

Heart/ 
Lung,& 




Institute 



Updated 
December 1978 



DHEW Publication No. (NIH) 79-705 

U.S. DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE 
Public Health Service National Institutes of Health 



^ir^ 



L/.?i 



«v,v^ i-m 




Subject Index of 

Current Research Grants and Contracts Administered 

by the National Heart, Lung, and Blood Institute 



Table of Contents 

Introduction 

Definition of Prefixes Used in Project Numbers . 

Initiai Review Groups 

Aiphabeticai Listing of Subjects 

Project identification and Investigator Address 
Alphabetical Listing of Investigators 



Page 

V 

■ • 

VII 

ix 
1 

523 
585 



III 



i 



i 



INTRODUCTION 

This publication contains information on research grants and contracts supported by the 
National Heart, Lung, and Blood Institute. It is published In the interest of providing tinnely 
information about the research supported by the National Heart, Lung, and Blood institute 
(grants and contracts active December 1978) and with an awareness that information for a 
few projects active at this time was not available. 

This index is prepared in cooperation with the Research Documentation Section, Statistics 
and Analysis Branch, Division of Research Grants, National Institutes of Health. It is based 
on the indexing of the System for the Computerized Retrieval of Information on Scientific 
Projects (CRISP). 

Project Identifiers 

Projects (grants and contracts) are identified in this index through a series of codes (see 
Definitions of Prefixes). Other codes designate the initial review groups (see Initial Review 
Groups). They appear in the various sections, as illustrated by the diagram below. 



Grant 



Contract 




P01 


HL 


12345 


-08 


007 


(HLBA) 


N01 


HV 


12345 


-02 




(HCRG) 



For a grant, the suffix is the approximate length of time a project has been supported; for a 
contract, the number of modifications. 

The following mnemonics are used as Institute designations: 

National Heart, Lung, and Blood Institute 

Division of Blood Diseases and Resources 

Division of Intramural Research 

Office of the Director 

Division of Lung Diseases 

Division of Heart and Vascular Diseases 

Alphabetical Listing of Subjects 

Subject headings are listed alphabetically. Under each subject heading relevant projects are 
listed numerically with their titles. 

In the case of large grants, the grant number is repeated under each subject heading for each 
relevant subproject, together with the appropriate subproject number. 



Grants: 


HL 


Contracts: 


HB 




HI 




HO 




HR 




HV 



Project Identification and Investigator Address 

Projects are arranged alphabetically according to the Institute designator (HB, HI, HL, HO, HR, 

HV). For each of these codes, projects are listed in numerical order. 

Several project directors within a parent grant may be listed. The institution address appears 
only with the first entry. kk^^c => 

Alphabetical Listing of Investigators 

The names of the principal investigators of active grants or contracts are listed alpha- 
betically. In the case of large grants where there are several subprojects, the name of one in- 
vestigator may be repeated several times. Numbers of subprojects which have been 
disapproved in the review process, or which have been completed, do not appear in this 

General 

By using the last two sections of this index in conjunction with each other, it is possible to 
determine who is doing what kind of research and where. 



i 



VI 



DEFINITIONS OF PREFIXES USED IN PROJECT NUMBERS 

N01-Research and Project Contracts: To develop and/or apply new knowledge or to test, 
screen, or evaluate a product, material, device or component for use by the scientific 
community. 

POI-Research Program Project Grants: For support of a multicategorical approach and usu- 
ally long-term program of research activity. These grants are usually directed toward 
a limited range of problems within a specific category, having a central research 
focus. 

P50-Speclalized Centers of Research: To support any part of the full range of basic to clini- 
cal research and development related to cardiovascular, pulmonary and blood 
diseases. These grants differ from program project grants in that they are usually 
developed in response to a program announcement and subsequently receive con- 
tinuous staff attention. 

P60-Comprehensive Centers: To support a multipurpose unit with the following objec- 
tives: fostering biomedical research and development both at the fundamental and 
clinical levels; community education, screening, and counseling programs; education 
of medical and allied health professionals; demonstration program on diagnosis, 
prevention and treatment of cardiovascular, pulmonary and blood diseases. 

R01 -Traditional Research Grants: To support a circumscribed project to be carried out 
under the direction of a named principal investigator In an area representing his or 
her specific interest and competencies. 

R10-Cooperatlve Clinical Research: To support clinical evaluation of various methods of 
therapy in specific disease areas. These are usually collaborative programs between 
sponsoring institutions and principal investigators, and usually conducted under a 
formal protocol. 

R13-Conference Grant: To support international or national meetings, conferences and 
workshops. 

R18-Research Demonstration and Dissemination Projects: To provide support designed to 
develop, test, and evaluate health service activities, and to foster the application of 
existing knowledge for the control of categorical diseases. 

R23-Young Investigator Award: A program of the National Heart, Lung, and Blood Institute 
to support basic and clinical studies for trained investigators to initiate new programs 
in the cardiovascular, pulmonary and blood diseases areas. 

R25-High Blood Pressure Education Research Program: A program with the following objec- 
tives: to foster research that would identify the characteristics of a hypertensive 
individual that are related to, or are suspected of relating to, adherence behavior; to 
develop educational interventions aimed at altering the behavioral characteristics of 
hypertensives to bring about immediate and long-term adherence to therapy. 



VII 



iJLA^WHIM^flES H^V^^lJ 



INITIAL REVIEW GROUPS 

qtudv sections and committees responsible for the initial technical review of research 
glant^ppllcations are listed with their abbreviations. Contracts are reviewed by ad hoc 
peer review groups. 

AFY — Applied Physiology and Orthopedics Study Section 

ALC — Alcohol Research Review Committee 

ALY — Allergy and Immunology Study Section 

AR — Animal Resources Advisory Committee 

BBCA - Biophysics and Biophysical Chemistry A Study Section 

BBCB - Biophysics and Biophysical Chemistry B Study Section 

BCM — Biomedical Communications Study Section 

BIO — Biochemistry Study Section 

BM — Bacteriology and Mycology Study Section 

BMT - Bioanalytical and Metaliobiochemistry Study Section 

BPS — Biopsychoiogy Study Section 

CBY — Cell Biology Study Section 

CLR — General Clinical Research Centers Committee 

CMS — Communicative Sciences Study Section 

CTY — Molecular Cytology Study Section 

CVA — Cardiovascular and Pulmonary Study Section 

CVB — Cardiovascular and Renal Study Section 

EDC — Epidemiology and Disease Control Study Section 

END — Endocrinology Study Section 

ET — Experimental Therapeutics Study Section 

EVR — Experimental Virology Study Section 

GEN — Genetics Study Section 

GmA — General Medicine A Study Section 

GMB — General Medicine B Study Section 

HBP - National High Blood Pressure Education Research Program Committee 

HCRG - Heart, Lung, and Blood Peer Review Groups for Contracts 

HOT — Health Care Technology Study Section 

HED - Human Embryology and Development Study Section 

HEM — Hematology Study Section 

HLBA - Heart, Lung, and Blood Research Review Committee A 

HLBB - Heart, Lung, and Blood Research Review Committees 

HSDG - Health Services Developmental Grants Study Section 

HUD — Human Development Study Section 

1MB — Immunobiology Study Section 

IMS — Immunological Sciences Study Section 

MCB — Microbial Chemistry Study Section 

MBY — Molecular Biology Study Section 

MCHA — Medicinal Chemistry A Study Section 

MET — Metabolism Study Section 

NEUA — Neurology A Study Section 

NEUB — Neurology B Study Section 



IX 



NSS 

NTN 

PCB 

PC 

PHRA 

PHY 

PTHA 

PTHB 

PTR 

RAD 

REB 

SAT 

SB 

SRC 

SSS 

TMP 

TOX 

VISA 

VISB 

VR 



— No Initial Review Group 

— Nutrition Study Section 

— Pathobiological Chemistry Study Section 

— Physiological Chemistry Study Section 

— Pharmacology Study Section 

— Physiology Study Section 

— Pathology A Study Section 

— Pathology B Study Section 

— Pharmacology-Toxicology Review Committee 

— Radiation Study Section 

— Reproductive Biology Study Section 

— Surgery, Anesthesiology and Trauma Study Section 

— Surgery and Bioengineering Study Section 

— Special Review Committee 

— Special Study Section 

— Tropical Medicine and Parasitology Study Section 

— Toxicology Study Section 

— Visual Sciences A Study Section 

— Visual Sciences B Study Section 

— Virology Study Section 



■m 



ABD 

ABDOMEN 

SU BODY REGIONS. ABOOMfN 

ABDOMINAL ARTERIES 

S(f CAKOIOVASCIIUR SYSIIM. ARTERIES, ABOOMINAl 
ARURItS 

ABETALIPOPROTEINEMIA 

SEE METABOUC DISORDERS INBORN, 

HYPOIIPOPROIEINEMIAS fAMIllAI. 
ABflAllPOPROHINEMIA 

ABO HEMOLYTIC DISEASE NEWBORN 

SEE BLOOD GROUP INCOMPAIIBIUIY PERINAIAl, ABO 
HEMOIYIIC DISEASE NEWBORN 

ABO(H) SYSTEM 

SEE BLOOD GROUPS. ABO (H) SYSTEM 

ABSCESS 

SEE DISEASES. PATHOLOGIC PROCESSES, INFLAMMATION. 
ABSCESS 

ABSORPTION 

SEE BIOLOGICAL TRANSPORT, MEMBRANE PERMEABILITY 
AND TRANSPORT 

ABSORPTION OF DIETARY NUTRIENTS 

SEE GASTROINTESTINAL FUNCTION. ABSORPTION TRANSPORT. 
DIETARY NUTRIENTS 

AC-GLOBULIN 

SEE BLOOD COAGULATION. FACTOR V 
ACADEMIC ACHIEVEMENT 

SEE PSYCHOLOGY. PERFORMANCE. ACADEMIC ACHIEVEMENT 

ACANTHROCYTOSIS (ABETALIPOPROTEINEMIA) 

SEE METABOLIC DISORDERS INBORN. 

HYPOLIPOPROTEINEMIAS FAMILIAL. 
ABETALIPOPROTEINEMIA 

ACAPNIA 

SEE RESPIRATORY GAS LEVELS. HYPOCAPNIA 

ACATALASEMIA 

SEE METABOLIC DISORDERS INBORN. ACATALASEMIA 

ACATALASIA 

SEE METABOLIC DISORDERS INBORN. ACATAUSEMIA 

ACCELERATION 

SEE ENVIRONMENT. GRAVITY-MOTION 

ACCELERATOR GLOBULIN 

SEE BLOOD COAGUUTION. FACTOR V 

ACCELERATORS (PARTICLE) 

SEE RADIATION. PARTICLE ACCELERATORS 

ACCELERIN 

SEE BLOOD COAGULATION. FACTOR V 
ACCIDENTAL SUFFOCATION 

SEE INJURIES. ACCIDENTS. SUFFOCATION 
ACCUMATIZATION 

SEE ENVIRONMENT. ADAPTATION. ACCLIMATIZATION 

ACETALDEHYDE 

SEE ALDEHYDES. ACETALDEHYDE 

ACET AMIDES 

SEE AMIDES. ACETAMIDES 
2-ACETAMIDO-ETHYL(P-CHLOROPHENYL)(N- 
TRIFLUOROMETHYL PHENYL PHENOXY) 
ACETATE 

SEE PHENOXYACETIC ACIDS. HALOFENATE 

ACETATE:COA LIGASE (AMP) 

SEE ACID-THIOL LIGASES. ACETATE:COA LIGASE (AMP) 

ACETATES 

SEE FATTY ACIDS. ACETATES 

ACETAZOLAMIDE 

SEE SULFONAMIDES. ACETAZOLAMIDE 

ACETOACETATES 

SEE FATTY ACIDS. ACETOACETATES 

ACETOPHENETIDIN 

SEE PHENYUMIDES. ACETOPHENETIDIN 

ACETYLATION 

SEE ACYLS. ACYLATION. ACETYLATION 

ACETYLCHOLINE 

SEE CHOLINE. ACETYLCHOLINE 
ACETYLCHOLINESTERASE 

SEE CHOLINE ESTERASES, ACETYLCHOLINESTERASE 

ACETYL COA 

SEE COENZYMES. COENZYME A. ACETYLCOA 

ACETYL-COA CARBOXYLASE 

SEE CARBON-CARBON LIGASES. ACETYL-COA CARBOXYLASE 



1 

ACETYl-C0A:C05 LIGASE (ADP) 

SH CARBON CARBON IICASI S. ACI lYl COA CARBOXYIASI 

ACETYL-COA SYNTHETASE (AMP) 

SEl ACID IHIOl IICASIS. AtllAIf COA IICASI (AMP) 
ACETYL COA TRANSACETYLASE 

SEE IRANSACYIASIS, ACI lYl COA IRANSACIIYLASl 

ACETYL-COENZYME A 

SEE COENZYMES, COl N/YME A, ACETYLCOA 

ACETYLENE COMPOUNDS 

SEE ALKYNES 
N-ACETYLGALACTOSAMINE 

SEE HEXOSES, GAIACTOSAMINES, N ACETYLGALACTOSAMINE 

N-ACETYLGIUCOSAMINIDASES 

SEE CARBOHYDRASES, N ACETYLCLUCOSAMINIDASES 
BETA-N-ACETYLHEXOSAMINIDASE 

SEE CARBOHYDRASES, HEXOSAMINIDASES 
N-ACETYU\AURAMIDE GLUCANOHYDROLASE 

SEE CARBOHYDRASES LYSOZYME 
N-ACETYLNEURAMINIDASE 

SEE CARBOHYDRASES, NEURAMINIDASE 

ACETYLSALICYLATES 

SEE PHENYLCARBOXYLATES, SALICYLATES. ACETYL- 

ACETYLTHIOKINASE (AMP) 

SEE ACID THIOL LIGASES, ACETATE:COA LIGASE (AMP) 

ACHIEVEMENT 

SEE PSYCHOLOGY, PERFORMANCE, ACADEMIC ACHIEVEMENT 

ACID-AMMONIA LIGASES, L- 

GLUTAMATE:AMMONIA LIGASE (ADP) 

ROlHL-11822 10 Biophysical studies of macromolecular 
interactions (microorganism, human) 

ACID-BASE BALANCE 

SEE BODY FLUID BALANCE, ACID-BASE 

ACID-FAST BACTERIA 

SEE BACTERIA, ACID-FAST BACTERIA* 
ACID PHOSPHATASE 

SEE PHOSPHOMONOESTERASES, ACID PHOSPHATASE 
ACID-THIOL LIGASES, ACETATE:COA LIGASE 
(AMP) 

ROlHL-12399-13 Specific fatty acids and cholesterol 
metabolism (gerbils, rats) 

ACIDITY OF URINE 

SEE URINE ACIDITY 

ACIDOSIS 

SEE BODY FLUID BALANCE, ACID-BASE, ACIDOSIS 

ACIDOSIS, DIABETIC 

SEE CARBOHYDRATES METABOLISM DISORDERS, DIABETIC 
ACIDOSIS 

ACIDOSIS, RESPIRATORY 

SEE RESPIRATORY DISORDERS, ACIDOSIS, RESPIRATORY 

ACIDOSIS INHIBITORS 

SEE BODY FLUID BALANCE, ACID-BASE, ANTIACIDOSIS DRUGS 

ACIDOSIS RENAL TUBULAR 

SEE METABOLIC DISORDERS (INBORN), RENAL TUBULAR 
ACIDOSIS 

ACIDS 

SEE ACIDS-BASES, ACIDS (GENERAL) 

ACIDS-BASES, ACIDS (GENERAL) 

SEE ALSO AMINES, HYDROXYLAMINES, HYOROXAMIC ACIDS 
SEE ALSO NITRATES 
SEE ALSO NUCLEIC ACIDS 
SEE ALSO PHOSPHATES 
SEE ALSO PHOSPHONATES 
SEE ALSO SULFATES 
SEE ALSO SULFONATES 
ROlHL-18028-03 Absorption of nonvolatile compounds 
from the lung 
ACIDS-BASES, ACIDS ORGANIC (GENERAL) 

ROlHL-04457-20 Cellular aspects of active transport (fish. 

rabbits, anurans. turtles) 
R23HL-22882-01 Modulation by disease of effect of 
furosemide in man 

ACIDS-BASES, ALKALIES 

ROlHL-20725-02 Mechanisms and cellular functions of ion 
transport 
ACIDS-BASES, BASES (GENERAL) 

SEE ALSO ACIDS-BASES. ALKALIES 
SEE ALSO ALCOHOLS 
SEE ALSO AMINES 
SEE ALSO STEROLS 
ROlHL-18028-03 Absorption of nonvolatile compounds 
from the lung 



ACI 



ACIDS-BASES, BUFFERS 

POIIIl iri'il U OOl'j Ctllulii ind mol«ful«i 

mech^nl•^m^ ut myorirdiil function Ell«ct\ of hypwn 
ind uch«mu on ion •«r.h«n|« tnd h«ir1 (unrlion (ribbil«( 
ROIHI 17879 09 0007 Pulmoniry lr»n'.por1 inrt 

metaboliim in vivo Oimolic compirtminlil model of 
btrrior euhanie 
•• P50H1 14718 0/ 0018 Pulmontry SCOR Newborn lunf 

center V«hole body buHerinj in tcule hypercepnn (do|») 
ROIHI 774/0 01 Lipowme myocardial uptake in infarct 
and r.cbcmia (do|\ r«l4, mice) 
ACIDS-BASES, HYDROGEN-ION 
CONCENTRATION 
SEE ALSO BODY flUID BALANCE. ACID BASE 
SEE ALSO RESPIRATORY GAS LEVELS, BOHR EFFECT 
N01HB62967 02 Red cell distributions in cyanale treated 

blood (human, sheep) 
ROIHL 00082 30 Transmembrane movements (barnacles, 

frogs, rats) 
ROIHL 02363 20 Kinetics of water and electrolytes in 

shock (dogs, rats) 
P01HL0628S 18 0198 Cardiovascular respiratory 

physiology and biochemistry Renal tubular secretion of 
hydrogen ion (animals) 
POIHL 07896 15 0030 Environmental biomedical research 
program Narcosis caused by inert gases at raised 
pressures (human, animals) 
POIHL 07896-15 0043 Environmental biomedical research 

program - Effect of hyperbaric oxygen on the lung (human, 
rabbits) 
POIHL 08899 14 0054 Tolerance to respiratory gases in 
health and disease Glucose transport across choroid 
plexus (dogs) 
ROIHL 12174 11 Ventilation/perfusion distribution in the 

lung (human, mammals) 
ROlHL-13841 16 Respiration during altitude 

acclimati2ation (goats, dogs. rats, rabbits) 
POlHL-14388 07 0180 Regulation of the circulation in 

pathological states Regulation of cerebral blood flow 
(dogs, monkeys) 
POlHL-14388 07 0218 Regulation of the circulation in 

pathological states - Regional myocardial dyskinesis-Cause 
assessment and reduction (dogs) 
R01HL14693-07 Survival value of physiological responses 

to hypoxia (dogs) 
ROlHL-14967-06 Chemoreceptor function in dynamic 

ventilatory control (human, dogs) 
P60HL 15157-07 0012 Comprehensive center for sickle 

cell disease - Sickling and intracellular pH (human) 
P60HL-15162-07 0019 Comprehensive sickle cell center - 

RBC-Blood rheology in sickle cell anemia and related 
disorders (human, animal) 
POlHL-15194-07 0006 Pathophysiology of 
cardiopulmonary dysfunction - Kinetics of gas exchange- 
Velocity of Bohr effect inerythrocytes(human) 
POlHL-15194-070009 Pathophysiology of 

cardiopulmonary dysfunction - Kinetics of gas exchange- 
Diffusion and erythrocytes reaction rates (human, dogs) 
POlHL-15194-07 0022 Pathophysiology of 

cardiopulmonary dysfunction - Kinetics of gas exchange- 
Pulmonary carbon dioxide exchange (dogs) 
ROlHL-16421-08 Determinants of RBC deformability and 

capillary flow (human, mice) 
R01HL-16''90-04 Structural basis of nephron filtration 

(rats, rabbits) 
POlHL-16878-05 0004 Control of ventilation in health 
and disease - Neurotransmitters in the respiratory system 
(cats) 
P50HL-17670-04 0022 Study of ischemic heart disease - 
Myocardial metabolism in hypoxia and recover (rabbit, 
toad, dog) 
" POlHL-17731-04 0010 Physiological basis of pulmonary 

disease - Gas exchange kinetics (dogs) 
ROlHL-18519-03 Albumin, endothelium and 

hemocompatibility (human, dog, cattle, rabbit) 
R23HL-19601-01 Cardiac response to chronic metabolic 

acidosis (rats) 
POlHL-19737-02 0005 Cellular and molecular aspects of 

respiratory physiology - Interaction of respiratory exchanges 
and blood gas parameters (human, animals) 
** ROlHL-20196-02 Regulation of coronary arterial smooth 
muscle 
ROlHL-20558-02 Cardiac electrophysiology -Effects of ions 

and drugs 
R01HL-20720-02 Myocardial protection during 

cardiopulmonary bypass (dogs) 
P01HL-20994-02 0009 Dynamics of neutrophil elastase in 

the lung - Biosynthesis and degradation of elastin in 
emphysema (human, hamsters) 
POlHL-21016-02 0004 Sickle cell anemia and other 

hemoglobinopathies - Kinetics of sickling 
POlHL-21016-02 0005 Sickle cell anemia and other 

hemoglobinopathies - Ligand kinetics in normal and Hb S 
containing erythrocytes (human) 
POlHL-21016-02 0006 Sickle cell anemia and other 

hemoglobinopathies - Analysis of the oxygen dissociation 
curve of Hb S-containing red cells 
POlHL-21016-02 0007 Sickle cell anemia and other 

hemoglobinopathies - Cellular determinants of red cell 
sickling 

(contd) 



•Excludes routine metliodology OR covers only general prajeds which preclude 
"Oriented significantly to above subiect. 



indexing at the specific level. 



M Grant has subpiojects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



ACI 

ROlHL-2 11 58-02 Cardiac receptors with vagal Cfiber 

afferents (cats) 
R23HL-21434-02 Intrinsic control of coronary blood flow by 

chemicals (guinea pigs) 
R23HL-21901-01 Hypertension, microvascular control and 

exercise (rats) 
ROlHL-22008-01 Lett ventrivular calcium content and 

contractility (rats) 
ROlHL-22080-01 Phosphorus NMR studies on cardiac 

tissue (rats, rabbits) 
ROlHL-22231-02 Modulation of calcium control of cardiac 

myofibrils (rats) 
ROlHL-22259-01 Modification of susceptibility to oxygen 

poisoning (rats) 
ROlHL-22315-01 Intraoperative cardiac oxygen supply- 
demand (dogs, rabbits, rats) 
ROlHL-22500-01 Conversion of choline to 

phosphatidylcholine in lung (rabbits, pigs) 
ROlHL-22568-01 pH effect in heart cells-Influence of 

cardiac drugs (tissue culture, rats) 
R23HL-22575-01 Factors modifying cardiac digoxin effects 

and content (dogs, cats) 
POlHL-22619-01 0005 Cellular mechanisms of heart 

failure - Molecular mechanism of regulation of cardiac 

muscle contraction (cattle) 
ROlHL-23900-01 Mechanical measurement of cell 

membrane viscosity (human) 

ACIDS-BASES, ISOELECTRIC POINT 

NOlHR-72923-01 Cystic fibrosis factor identification and 
quantification (human) 

ACONINE TYPE ALKALOIDS 

SEE ALKALOIDS, ACONINE TYPE 

ACONITUM ACONINE TYPE ALKALOIDS 

SEE ALKALOIDS, ACONINE TYPE 
ACOUSTIC HOLOGRAPHY 

SEE OPTICS. PHOTOGRAPHY, HOLOGRAPHY, ACOUSTIC* 
ACOUSTIC MICROSCOPY 

SEE OPTICS, MICROSCOPY, ULTRASONIC* 

ACRIDINES 

ROIHLI 7702-04 Electro^ptical dyes as probes of heart 
excitability 

ACRIDINES, AMINOACRIDINES 

R01HL-08508-15 Cardiac conductivity and automaticity 
(human, dogs, rabbits) 

ACRIDINES, QUINACRINE 

ROlHL-17702-04 Electro-optical dyes as probes of heart 
excitability 

ACROMEGALY 

SEE PITUITARY GLAND DISORDERS, ACROMEGALY 
ACRYLIC POLYMERS (RESINS) 

SEE PUSTICS, ACRYLIC POLYMERS 
ACTASCAN 

SEE RADIOGRAPHY, SCANNING, CAT* 
ACTH 

SEE PITUITARY-DIENCEPHALON HORMONES, ACTH 
ACTH INHIBITORS 

SEE PITUITARY-DIENCEPHALON HORMONES, ACTH INHIBITORS 

ACTIN 

SEE MUSCLE PROTEINS (AND CONTRACTILE PROTEINS) 
ACTIN 

ALPHA-ACTININ 

SEE MUSCLE PROTEINS (AND CONTRACTILE PROTEINS) 
ALPHA-ACTININ 

ACTINOMYCIN 

SEE ANTIBIOTICS, ACTINOMYCIN 
SEE ANTIBIOTICS, ACTINOMYCIN D 

ACTINOZOA 

SEE COELENTERATES, ANTHOZOA* 
ACTION POTENTIALS 

SEE ELECTROPOTENTIALS, ACTION POTENTIALS 
ACTIVATION OF LYMPHOCYTES 

SEE IMMUNITY, CELLUUR, LYMPHOCYTE ACTIVATION, 
TRANSFORMATION AND PROLIFERATION 
ACTIVATION PRODUCT 

SEE BLOOD COAGULATION, ACTIVATION PRODUCT 
ACTIVE IMMUNIZATION 

SEE IMMUNITY, IMMUNIZATION ACTIVE 
ACTIVE TRANSPORT 

SEE BIOLOGICAL TRANSPORT, ACTIVE TRANSPORT 
ACTOMYOSIN 

SEE MUSCLE PROTEINS (AND CONTRACTILE PROTEINS) 
ACTOMYOSIN 

ACUTE DISEASES (DISORDERS) 

SEE DISEASES, ACUTE (GENERAL) 



ACUTE LEUKEMIA 

SEE NEOPLASMS OF BLOOD AND RE SYSTEM, LEUKEMIA 
ACUTE 

ACUTE PHASE PROTEINS 

SEE IMMUNOLOGY, ACUTE PHASE PROTEINS 
ACUTE RENAL FAILURE (LOWER NEPHRON) 

SEE KIDNEY DISORDERS, NEPHROSIS LOWER NEPHRON 
ACUTE TREATMENT.DRUGS 

SEE DOSAGE AND ROUTE, RATE AND DURATION OF 
ADMINISTRATION 

ACYLATION 

SEE ACYLS, ACYLATION 
ACYL-COA 

SEE COENZYMES, COENZYME A, ACYL-COA 
ACYl COENZYME A DEHYDROGENASES 

SEE OXIDOREDUCTASES, ACYL-COA DEHYDROGENASE 
ACYL-COENZYME A 

SEE COENZYMES, COENZYME A. ACYL COA 
ACYL GROUPS 

SEE ACYLS, ACYL GROUPS 
ACYLS, ACYL GROUPS 

R01HL-15646-03 Lipid studies in vascular smooth muscle 

cells (human, monkeys) 
R01HL-20308-02 Regulation of myocardial acylcarnitine 

transport (rats) 
R23HL-21251-01 Metabolism of neutral lipids in the 

pulmonary alveolus (rabbits) 

ACYLS, ACYLATION 

ROlHL-13567-06 Ion transport across cell membranes 

(human) 
ROlHL-18181-04 Surfactant metabolism-Alveolar cells and 

lung disease (mice, rabbits) 
ROlHL-22566-01 Mesoionic purinones as 

phosphodiesterase inhibitors 
POlHL-226 19-01 0007 Cellular mechanisms of heart 

failure • Regulation of contractile protein levels in heart 

muscle (rats) 
ROlHL-22651-01 Control of protein metabolism in heart 

muscle 

ACYLS, ACYLATION, ACETYLATION 

POlHL-12738-10 0001 Physiologicpharmacology and its 

clinical applications - Clinical pharmacology of cardioactive 

drugs (human) 
P50HL-14147-08 0001 Specialized center of research in 

thrombosis Role of aspirin, other anti-platelet agents in 

platelet function (rat. human) 
ROIHL 17947-04 Experimental renal and neurogenic 

hypertension (human, animals) 
ROIHL 20794-02 Prostaglandin synthesis in human 

platelets (also in sheep, rabbit) 
** ROlHL-20925-01 The acetylation of fetal hemoglobin 

(human) 

N-ACYLSPHINGOSINE 

SEE SPHINGOUPIDS, CE.RAMIDE 

ACYLTRANSFERASES 

SEE TRANSACYLASES 

ADAMS-STOKES SYNDROME 

SEE HEART DISORDERS, ARRHYTHMIA, HEART BLOCK 
STOKES-ADAMS SYNDROME 

ADAPTATION BIOLOGICAL, PHYSIOLOGICAL 

SEE ENVIRONMENT, ADAPTATION 

ADAPTATION, PSYCHOLOGICAL 

SEE PSYCHOLOGICAL ADAPTATION 
ADDISON'S DISEASE 

SEE ADRENAL GUNDS DISORDERS, ADDISON'S DISEASE 
ADENINE 

SEE PURINES, ADENINE 
ADENINE NUCLEOSIDE 

SEE PURINE NUCLEOSIDES, ADENINE NUCLEOSIDES 
ADENINE NUCLEOTIDES 

SEE PURINE NUCLEOTIDES, ADENINE NUCLEOTIDES 

ADENINE PHOSPHORIBOSYLTRANSFERASE 

SEE GLYCOSYLTRANSFERASES, ADENINE 
PH OSPHORIBOSYLTRANSFERASE 
ADENOMA 

SEE NEOPLASMS, ADENOMA 
ADENOSINE 

SEE PURINE NUCLEOSIDES, ADENINE NUCLEOSIDES 
ADENOSINE 

ADENOSINE DEAMINASE 

SEE AMINOHYDROLASES. ADENOSINE DEAMINASE 
ADENOSINE DIPHOSPHATE 

SEE PURINE NUCLEOTIDES, ADENINE NUCLEOTIDES, AOP 



ADR 



•Excludes routine methodology OR covers only general projects which preclude indexing 
"Oneiited significantly to above subject. 



at the specific level. 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



ADENOSINE MONOPHOSPHATE 

SEE PURINE NUCLEOTIDES, ADENINE NUCLEOTIDES. AMP 
ADENOSINE MONOPHOSPHATE CYCLIC 

SEE PURINE NUCLEOTIDES, ADENINE NUCLEOTIDES AMP 
CYCLIC 

ADENOSINE PHOSPHATES 

SEE PURINE NUCLEOTIDES, ADENINE NUCLEOTIDES 
ADENOSINE PHOSPHATES 

ADENOSINE TRIPHOSPHATASE 

SEE PHOSPHATASES, ADENOSINE TRIPHOSPHATASE 
ADENOSINE TRIPHOSPHATE 

SEE PURINE NUCLEOTIDES, ADENINE NUCLEOTIDES, ATP 
S-ADENOSYLMETHIONINE 

SEE NUCLEOSIDYL AMINO ACIDS, S-ADENOSYLMETHIONINE 
ADENOVIRUSES 

SEE VIRUSES, ADENOVIRUSES 
ADENYLATE CYCLASE 

SEE NUCLEOTIDYL-CYCLASES. ADENYUTE CYCUSE 
ADENYLATE DEAMINASE 

SEE AMINOHYOROUSES, ADENYUTE DEAMINASE 
ADENYLATE KINASE 

SEE PHOSPHOTRANSFERASES, ATP:AMP 
PHOSPHOTRANSFERASE 

ADENYL-5-PHOSPHATASE 

SEE PHOSPHOMONOESTERASES, 5 -NUCLEOTIDASE 
ADH 

SEE PITUITARY-DIENCEPHALON HORMONES, VASOPRESSIN 
ADHESION 

SEE PHYSICAL PROPERTIES, ADHESION 
ADHESIONS (DISEASE COMPLICATIONS) 

SEE DISEASES. COMPLICATIONS. ADHESIONS 
ADHESIVES 

SEE SURGICAL ADHESIVES 

ADIPOKINETIC SUBSTANCES, PITUITARY 

SEE LIPID MOBILIZING FACTORS PITUITARY 
ADIPOSE TISSUE 

SEE CONNECTIVE TISSUE. ADIPOSE 
ADJUNCT HEALTH (CARE) PERSONNEL 

SEE HEALTH SCIENCES PROFESSIONS. HEALTH (CARE) 
PERSONNEL ALLIED 

ADJUNCT MENTAL HEALTH PERSONNEL 

SEE MENTAL HEALTH PERSONNEL ADJUNCT 
ADJUSTMENT, EMOTIONAL 

SEE PSYCHOLOGICAL ADAPTATION. EMOTIONAL ADJUSTMENT 
ADJUSTMENT, SOCIAL 

SEE PSYCHOLOGY SOCIAL. SOCIAL ADJUSTMENT 
ADJUSTMENT TO ENVIRONMENT 

SEE ENVIRONMENT. ADAPTATION 
ADJUVANTS lAAMUNOLOGtC 

SEE IMMUNOLOGICAL PREPARATIONS. ADJUVANTS 
IMMUNOLOGIC 

ADMINISTRATION 

SEE HEALTH ADMINISTRATION 
ADOLESCENCE 

SEE CHILDREN. ADOLESCENCE (12 TO 21 YRS) 
ADP 

SEE PURINE NUCLEOTIDES. ADENINE NUCLEOTIDES. ADP 

ADRENAL CIRCULATION 

R01HL-21308-01 Prostaglandins and local control of the 
circulation (rats, dogs) 

ADRENAL CORTEX HORMONES 

SEE ALSO GLOBULINS. CORTICOSTEROID BINDING GLOBULIN 
ROlHL-05883-18 0001 Reflex control of resistance and 

capacitance vessels - Naturally occurring vasoactive 

substances and the vascular neuroeffectors (dog) 
POlHL-06285-18 0209 Cardiovascular-respiratory 

physiology and biochemistry - Metabolic studies of isolated 

lung cells (human, animals) 
POlHL-06370-17 0014 Cardiopulmonary and renal 

pathology research center - Quantitative morphology in 

cardiac disease (human, rats, dogs) 
POlHL-06664-17 0010 Cardiopulmonary function in 

remediable vascular disease - Ischemia and acute renal 

failure (rats) 
POlHL-11351-12 0015 Cellular and molecular 

mechanisms of myocardial function - Effects of hypoxia 

and ischemia on ion exchange and heart function (rabbits) 
** POlHL-11414-11 0014 Thrombosis and atherosclerosis 

program - Role of adrenal in human essential hypertension 
P50HL 14218-07 0017 Pulmonary SCOR-Newborn lung 

center - Transvascular fluid exchange, vasoactive mediators 

in RDS (sheep, cat) 

(contd) 



\ 



i 



ADR 



ROIHI U854 07 lum tnd ti8»u» mechiniCJ (monkeys. 

dofs) 
PSOHl 15061 O; 0009 Response ol luni lo iniury 

Alveolii miciophiies (human, tabbi(s) 
ROIHI 1H16 07 lunj surticlanl system Contiol 

mechinisms (lats) 
POIHI 16137 05 0013 Alveolai biolojy Development and 

patlioloiy ol surtactant foimation ol alveolar (tabbils. 

sheep) 
ROIHI 16611 04 Digitalis receptot ol the heart (guinea 

pigs, lats) 
ROIHL 16651 05 Evaluation ol steioid theiapy in 

sarcoidosis (human) 
ROIHL 1671003 Myocardial subcellular localization of 

calcium (dogs) 
ROIHL 17903 03 Regional circulatory responses to hypoxia 

(rats. cats, rabbits) 
ROIHL 1820* 03 Regional blood How in viral myocarditis 

(turkeys) 
POIHL 18208 04 0003 Center lor the study ol blood cell 

rheology Bone marrow mrciocirculation (rats, mice) 

• P50HL 18323 04 0037 SCOR hypertension center 

Adrenocortrcal lactors in chrldhood hypertension 

• P50HL 18323 04 0038 SCOR hypertension center • 

Unknown adrenocortical mechanisms in hypertension 
(human) 
POIHL 18645 03 0003 Biology ol the artery wall and 
atherosclerosis Synthesis of connective tissue proteins by 
smooth muscle cells (human, monkeys) 
ROIHL 1876203 Posttraumatic pulmonary insufliciency 

(dogs) 
P01HL1882702 0006 Platelet vessel wall interactrons in 
thrombogenesis Platelet immune injury In man 
'* ROIHL 18923-02 Steroid-induced hyperlipidemia and 
hypertension (human, rats) 
ROlHL-1901003 Metabolism and cell biology of lung 

surtactant system (rabbits, sheep) 
P50HL-19187-02 0001 Pediatric pulmonary SCOR-Hyaline 
membrane disease Hyaline membrane disease -Changes 
in lung mechanics and gas exchange (monkeys) 
P50HL1918702 0002 Pediatric pulmonary SCOR-Hyaline 
membrane disease - Hyaline membrane disease-Alterations 
in surface active material (monkeys) 
ROlHL-19237-03 Obstructive lung disease and alveolar 
macrophages (human, animals) 
** R01HL-1953903 Pathology of hypertensrve-associated 
arteritis (rabbits) 
R0IHL19669-03 Lung organ culture and surfactant 
biosynthesis (adult and fetal rats) 
** PO1HL1971702 0027 Response of the lung to in|ury - 
Hormone control ol lung growth and development (rats) 
POIHL-19717-02 0038 Response of the lung to injury • 
Interstitial lung disease -Clinical, pathologic and 
epidemiologic 
P01HL1971702 0039 Response of the lung to injury - 
Lung scanning in alveolitis and asbestolrc interstitial 
pneumonia (human, animal) 
P01HL-I971702 0040 Response of the lung to injury - 
Immunosuppressive drugs in usual interstitial pneumonia 
(human) 
ROlHL-19722-03 Aerosol growth in the respiratory system 

(models) 
R01HL1978202 Pharmacologic studies on the ischemic 

heart (dogs) 
ROlHL-20080-02 Surgically induced myocardial edema 

(dogs) 
ROlHL-20384-09 Social stimulation. RNA and 

cardiovascular disease (animals) 
R01HL-2090502 Synthesis of fetal hemoglobin in erythroid 

cells (sheep, human) 
R01HL-21140-01 Studies of pulmonay alveolar 

macrophage function (rabbits) 
ROlHL-21418-02 Experimental myocardial infarction (rats) 
ROlHL-21628-02 Biosynthesis of lung surfactant lipid 
(rabbit) 
*♦ R23HL-21917-01 Adrenal steroids in adolescent and adult 
hypertension 
ROlHL-2206501 Intractability, medication, and coping 

styles in asthma (human) 
ROIHL-2226601 Production of proteases by lung cells in 

culture (human, rodents, rabbits, sheep) 
ROlHL-22547-01 Behavioral treatment of Raynaud's 

disease (human) 
ROlHL-2256302 Prostaglandins, the kidney and 

hypertension (rats) 
ROlHL-2287301 Adrenoceptor interconversion and 

hormone homeostasis 
ROlHL-23981-01 Acute alveolar injury (dogs) 
** NOIHR-62948-04 Evaluate antenatal steroid therapy in 

neonatal respiratory distress syndrome 
** NOlHR-62949-05 Evaluate antenatal steroid therapy in 

neonatal respiratory distress syndrome 
** NOlHR-62950-04 Evaluate antenatal steroid therapy in 

neonatal respiratory distress syndrome 
" NOlHR-6295104 Evaluate antenatal steroid therapy in 

neonatal respiratory distress syndrome 
** NOlHR-62952-05 Evaluate antenatal steroid therapy in 
neonatal respiratory distress syndrome 

ADRENAL CORTEX HORMONES, ALDOSTERONE 

SEE ALSO ADRENAL CORTEX HORMONES. ALOOSTERONE 
STIMULATING FACTORS 



SEE AlSOAORLNAl CORKX HORMONIS 4 I'RK.NI Nt 

IIBIIA 1H7I IRIOl 1,20 DIOm 
SEE AISOADRfNAl GIANDS DISOHDI RS 

HYIMRAIOOSIIRONISM 
SEE AlSOAORfNAl CiANDS OlSOROfKS 
HYPOAIDOSIIRONISM 
ROIHL 00759 29 Regulation ol electrolyte and acid base 

equilibrium (dogs) 
ROIHI 02493 ?2 Kidney lunction in experimental heart 

lailure (dogs, rats) 
ROIHL 03303 21 factors regulating electrolyte excretion by 
the kidney (human, dogs) 
■• POIHL 06285 18 0193 Cardiovascular fespiralory 
physiology and biochemistry Hormonal regulation ol 
sodium transport Aldosterone (rats, toads) 
'* POIHL 06285 18 0194 Cardiovascular respiratory 
physiology and biochemistry Hormonal regulation ol 
sodium transport RNA synthesis (rats, toads) 
POIHL 06285 18 0196 Cardiovascular resprratory 
physiology and biochemistry Hormonal regulation ol 
sodium transport Epithelial cell membranes (toads) 
P01HL06285 18 0199 Cardiovascular respiratory 
physiology and biochemistry Renal tubular reabsorption ol 
sodium chloride (hamsters, rabbits) 
P01HL06664 17 0040 Cardiopulmonary functron in 
remediable vascular drsease The coupling of ion transport 
to metabolism (toads) 
POIHL 0683517 0030 Cardiovascular disease Synthesrs 
and pharmacology of angiotensin antagonists (rats, cats) 
** POIHL 06835 17 0032 Cardiovascular disease • Synthesis 
of angiotensin II as inhibitors lor aldosterone 
POlHL-06835 17 0050 Cardiovascular disease 18 
Hydroxylase block in the 17 alphahydroxylase deficiency 
syndrome (human) 
POlHL-0683517 0055 Cardiovascular disease Vascular 
and adrenocortical response to angiotensin II (dogs) 
** POlHL-0683517 0055 Cardiovascular disease - 
Angiotensin analogs Sarcosine on arterial pressure, 
aldosterone (dogs) 
R01HL06975-18 Pathogenesis and preventron of 

hypertension (rats) 
ROlHL-0991112 Hormonal and dietary modification of 
NaCl toxicity (rats) mice) 
** R01HL09921 13 Mechanisms related to congestive heart 

failure (dogs, human, rat) 
M ROIHL 10612-13 Humoral lactors rn heart failure and 
hypertension 
ROlHL-10612-13 0018 Humoral factors in heart failure 
and hypertension • The pathogenesis of experimental renal 
hypertension (dogs, rabbits, rats) 
** ROlHL-10612-13 0019 Humoral factors in heart failure 
and hypertension - Pathogenesis of hypertension in the 
spontaneous hypertensive rat 
ROIHL 10612 13 0020 Humoral factors in heart failure 
and hypertension The control of renin release in the dog 
** ROlHL-10612-13 0021 Humoral factors in heart farlure 
and hypertension - The control of aldosterone secretion 
(dogs) 
•• ROlHL-11046-12 Renin, angiotensin, steroids, ions and 
blood pressure (human, sheep, rabbits) 
POlHL-11414-11 0014 Thrombosis and atherosclerosis 
program - Role of adrenal in human essential hypertension 
M POlHL-1167811 Cardiovascular dynamics and their 
control 
P01HL11678-11 0034 Cardiovascular dynamics and their 

control - Renal function curves in intact dogs 
POIHL 11678-11 0040 Cardiovascular dynamics and their 
control - Control of plasma potassium concentration (dogs) 
** POlHL-11678-11 0046 Cardiovascular dynamics and their 
control ■ Regulation of aldosterone secretion and related 
factors (dogs) 
" POlHL-11678-11 0047 Cardiovascular dynamics and their 
control ■ Unidentified pituitary factor in regulation of 
aldosterone secretion (rats) 
POlHL-11678-11 0065 Cardiovascular dynamics and their 
control Body fluid volumes in the genesis of hypertensron 

Cogs) ^ .^ . 

** POlHL-1 1678-11 0066 Cardiovascular dynamics and their 

control - Closed-loop analysis of the aldosterone control 

system (dogs) 
** R01HL13917-20 Secretron and effects of adrenal 

hormones (human, rabbits, sheep) 
** ROlHL-14148-07 0007 The regional circulations ■ Salivary 

composition in hypertension (human) 
P50HL-1415908 0008 Specialized center of research in 

hypertension - Renal function and sodium metabolism in 

hypertension (rats, human, rabbits) 
P50HL 14159-08 0020 Specialrzed center of research in 

hypertension ■ Renin-mineralocorticoid system in 

hypertension (human, rat, dog) 
P50HL 1415908 0021 Specialized center of research in 

hypertension - Genetic studies of the physiology of 

hypertension (human, rats) 
P50HL-14159-08 0022 Specialized center of research in 

hypertension - Core laboratory 
P50HL1419208 0003 Specialized center of research in 

hypertension - Prostaglandins as mediators of renin 

secretion (human, dog) 
P50HL-14192-08 0007 Specialized center of research in 

hypertension - Role of new mineralocorticoids in 

hypertension (human, rats) 



ADR 

ROIHI 1 4 106 0/ Quanlilicalion ol artf rial pmiure control 

(do|\) 
POIHI 14388 0/ UIX8 R«|ul<lion ol the circulaliofl in 

pathological \\t\*\ Renin in(ialen-.in jyilam in th» ihMp 

lelu\ 
' POIHI 14388 0/ 0190 Regulation ol the circulation in 

pathological states Mechanism-, ol the renal actiont of 

aldosterone (rats) 
POIHI 14388 0/ 0191 Regulation ol Ihe circulation in 

pathological states Regulation ol chloride transport in 

epithelial membranes (turtles) 
POIHL 14388 07 0223 Regulation of Itie circulation in 

pathological states Kallikrem kinin system in hypertension 

(rats) 
POIHL 14388 0/ 0274 Regulation ol the circulation in 

pathological states Kallikrem kinin system in hypertension 

(human) 
POIHL 14388 0/ 9002 Regulation ol Ihe circulation in 

pathological stales Core immunoassay laboratory (rabbrts) 
ROIHL 1649604 Prostaglandins and renin experimenlal 

hypertension (rabbits) 
ROIHL 1665805 Intrarenal regulation ol sodium 

reabsorption 
ROIHL 1691805 Role of steroids in hypertension (human) 
ROIHL 1736404 Big renin' Biochemical and clinical 

studies (human) 
ROIHL 1770504 Kallikrem kinin system in hypertension 

(human, rats, dogs) 
'• ROIHL 17847 04 Cardiovascular and renal lunctions ol 
marmots 
ROIHL 17958 04 Circulatory effects of operant 

cardiovascular control (baboons) 
P50HL 18318 03 0003 Pathogenesis and complications ol 

hypertension Core biochemical laboratory 
P50HL 1831803 0004 Pathogenesis and complications of 
hypertension Sterord and renin profiles in hypertension 
(rats, human) 
P50HL 18318-03 0014 Pathogenesis and complications of 
hypertension Arterial metabolism and atherogenesis (rat, 
rabbit) , 

P50HL18318-03 0019 Pathogenesis and complications of 
hypertension - Renin angiotensin system in blood pressure 
regulation (human, rat, dog) 
P50HL-18323-04 0011 SCOR hypertension center ■ 
Endocrine profiling on a selected normal population 
(human) 
P50HL18323-04 0012 SCOR hypertension center ■ Renin 
as a risk factor (human) 
*• P50HL-1832304 0033 SCOR hypertension center - Core 
laboratory-Renin, aldosterone and bradykinin methodology 
P50HL-18323-04 0038 SCOR hypertension center - 
Unknown adrenocortical mechanisms in hypertension 
(human) 
** P50HL18323-04 0043 SCOR hypertension center - 

Pharmacology -Renin-aldosterone mechanisms in essential 
hypertension (human) 
POIHL 18575-03 0002 Mechanisms of vascular changes 
in hypertension Endocrines, electrolytes, and 
hemodynamics in hypertension (pigs) 
POlHL-18575-03 0011 Mechanisms of vascular changes 

in hypertension ■ Chemistry laboratory core facility 
ROlHL-18624-03 Study of kinins in hypertension and other 

diseases (human) 
ROlHL-18862-02 Thirst and its contribution to edema 
(dogs) 
** ROIHL-18882-02 Hormones in hypertension (human) 
ROlHL-18891-02 Electrolyte intake and blood pressure in 

hypertension (human) 
ROlHL-18893-03 Mechanism of angiotensin action -Role of 
receptor (rats) 
** ROlHL-1927903 Intracellular action of aldosterone in 
hypertension (human, rats) 
ROlHL-19287-03 The antihypertensive function of the 

renal medulla (human, rats, rabbits) 
P50HL-19362-02 0010 A/S SCOR-Atherosclerosis in 
nonhuman primates - Antihypertensive therapy- 
Atherogenesis in experimental hypertension (baboon) 
ROlHL-19428-03 Role of angiotensin sensitivity in renin 

release (human) 
ROlHL-19467-03 Regulation of blood pressure (rats, dogs) 
ROlHL-1953903 Pathology of hypertensive-associated 

arteritis (rabbits) 
R01HL19644-03 Etiological factors in hypertension 
(human, dogs, rats) 
** ROlHL-20176-02 Biochemistry and genetics of salt 

hypertension (rats) 
** ROIHL 20201-01 Hypertension and vascular steroid 
receptors (rats) 
ROIHL 20572-02 0003 Hemodynamic relations to 

metabolism in hypertension Cardiac output and organ 
blood flow In hypertension (rats) 
** R23HL-2106602 Angiotensin and prostaglandin control of 
aldosterone (rats) 
ROlHL-21092-02 Factors other than renin in renal 
hypertension (rats) 
'* ROlHL-21 112-02 Aldosterone binding, clearance, and 
secretion in man 
ROlHL-21435-02 Control, cardiovascular and renal effects 

of potassium (dogs) 
R23HL-21917-01 Adrenal steroids in adolescent and adult 
hypertension 

(contdl 



•txcluoes routine methodology OR covers only general proiects which preclude indexing at Ihe specific level 
•*Oriented significantly to above sut))ect 



M Grant has subprojects describing specific research aspects. 
See Appendix lor investigators name and grant number. 



AOR 

** ROlHL-21996-01 Alteration of digitalis and aldosterone 

disposition (ratsr rabbits, mice, dogs) 

ROlHL-22069-02 Experimental renal arterial tiyperlension 

(dogs) 

ROlHL-2229802 Origins of hypertension (human) 

ROIHL-22617-01 Angiotensin, hypertension and the CNS 

(sheep) 

ROlHL-22990-01 Angiotensin II receptors-Mechanisms of 

regulation (rats) 

ROlHL-23115-01 Regulation of active sodium transport 

(frogs, rats) 
ROlHL-2320101 Mechanisms of hypertension (human 

rats) 
ROIHL-23602 01 Physiology of renin, aldosterone and 

prostaglandin (human, rats, dogs) 

ADRENAL CORTEX HORMONES, ALDOSTERONE 
INHIBITORS 

SEE ALSO STEROIDS SPIROUCTONES. SPIRONOUCTONE 
POlHL-06835-17 0055 Cardiovascular disease ■ Vascular 
and adrenocortical response to angiotensin II (dogs) 

ADRENAL CORTEX HORMONES, ALDOSTERONE 
STIMULATING FACTORS 

SEE ALSO PEPTIDES. VASOACTIVE PEPTIDES ANGIOTENSIN II 
SEE ALSO PITUITARY-DIENCEPHALON HORMONES ACTH 
P50HL-18323-04 0044 SCOR hypertension center - 
Angiotensin blockade to identify angiotensin II factor in 
hypertension (human) 

ADRENAL CORTEX HORMONES 
CORTICOSTERONE 

ROlHL-0697518 Pathogenesis and prevention of 

hypertension (rats) 
ROIHLI 1046-12 Renin, angiotensin, steroids ions and 

blood pressure (human, sheep rabbits) 
POlHL-1 1310-12 0063 Mechanisms of cardiovascular 

disease - Myocardial function, metabolism and cellular 

integrity after heart surgery (dogs) 
ROlHL-17706-04 Psychosocial hypertension, 

catecholamines and drugs (mice) 
P50HL-1831803 0004 Pathogenesis and complications of 

hypertension - Steroid and renin profiles in hypertension 

(rats, human) 
P50HL-I8323-04 0038 SCOR hypertension center - 

Unknown adrenocortical mechanisms in hypertension 

(human) 
ROlHL-19644-03 Etiological factors in hypertension 

(human, dogs, rats) 
R23HL 2191701 Adrenal steroids in adolescent and adult 

hypertension 

ADRENAL CORTEX HORMONES, CORTISONE 

POlHL-06370-17 0013 Cardiopulmonary and renal 

pathology research center - Morphologic analysis of 

vascular prosthesis (human, dogs) 
ROlHL-12085-10 Lipoprotein-carbohydrate metabolism 

(human, rats) 
ROlHL-12766-09 Structure-function relation of blood 

vessels (rats, monkeys) 
POlHL-16769-05 0010 Pathobiologic and host defense 

reactions m the lung - Bronchus associated lymphoid 

tissue and delayed hypersensitivity (rabbits) 
ROIHL 18028-03 Absorption of nonvolatile compounds 

from the lung 
POlHL-18576-03 0007 Thrombosis research program 

project - Relationships between coagulability and 

thrombosis (human, animals) 
POlHL-19717-02 0007 Response of the lung to injury - 

Cellular level studies of prostaglandin-like molecules 

(cattle) 
R23HL 21997-01 Pulmonary immunopathology in the 

compromised host (guinea pigs) 

ADRENAL CORTEX HORMONES 
DEOXYCORTICOSTERONE 

R01HL00759-29 Regulation of electrolyte and acid base 

equilibrium (dogs) 
R01HL-0991M2 Hormonal and dietary modification of 

NaCl toxicity (rats) mice) 
ROlHL-l 1046-12 Renm, angiotensin, steroids, ions and 

blood pressure (human, sheep rabbits) 
P50HL 14192-08 0007 Specialized center of research in 
hypertension - Role of new mineralocorticoids in 
hypertension (human, rats) 
ROlHL-14560-07 Hypertension produced by sympathetic 

dysfunction (human, rats) 
ROIHL 16658-05 Intrarenal regulation of sodium 

reabsorption 
ROIHL-1691805 Role of steroids in hypertension (human) 
ROIHL 17516-04 Role of androgen as a risk factor in 

atherogenesis (human, animals) 
P50HL-1831803 0003 Pathogenesis and complications of 

hypertension - Core biochemical laboratory 
P50HL 18318-03 0004 Pathogenesis and complications of 
hypertension ■ Steroid and renin profiles in hypertension 
(rats, human) 
P50HL-18318-03 0009 Pathogenesis and complications of 
hypertension - The mineralocorticoid-hypertensive syndrome 
in man 
P50HL 18323-04 0038 SCOR hypertension center - 
Unknown adrenocortical mechanisms in hypertension 
(human) 



PC1HL18575-03 0002 Mechanisms of vascular changes 

in hypertension ■ Endocrines, electrolytes, and 

hemodynamics in hypertension (pigs) 
POIHL 18575-03 0005 Mechanisms of vascular changes 

in hypertension - Renin synthesis in normotensive and 

hypertensive pigs (also rats, dogs) 
POIHL 18575-03 0011 Mechanisms of vascular changes 

in hypertension - Chemistry laboratory core facility 
ROlHL-2017602 Biochemistry and genetics of salt 

hypertension (rats) 
ROlHL-2111202 Aldosterone binding, clearance, and 

secretion in man 

ADRENAL CORTEX HORMONES, ll-DEOXY-l?- 
HYDROXYCORTICOSTERONE 

POlHL-06835-17 0050 Cardiovascular disease - 18- 

Hydroxylase block in the 17 alpha-hydroxylase deficiency 

syndrome (human) 
ROlHL-06975-18 Pathogenesis and prevention of 

hypertension (rats) 
P50HL-1832304 0038 SCOR hypertension center - 

Unknown adrenocortical mechanisms in hypertension 

(human) 
R23HL-21917-01 Adrenal steroids in adolescent and adult 

hypertension 

ADRENAL CORTEX HORMONES, 
GLUCOCORTICOIDS 

POlHL-1034213 0027 The integrated function of 
respiration and circulation - Control of respiration - 
Cardiovascular adjustment to hypoxia and carbon monoxide 
ROlHL-12990-09 Control of antidiuretic hormone secretion 

and metabolism (dogs, rats, rabbits) 
R01HL13595-08 Renin and vascular hyperreactivity in 

hypertension (human, rats) 
P50HL-14214-07 0023 Newborn lung center for hyaline 
membrane disease - Regulation of fetal lung maturation - 
Vitamin A (rat. rabbit, sheep, human) 
P50HL-14214-07 0024 Newborn lung center for hyaline 
membrane disease Synthesis and receptors for ACTH in 
fetal lung (human) 
R01HL15341-06 Lung hormonal and chromosomal 

regulation (rats, rabbits) 
ROlHL-16219-05 Mechanisms of atherogenesis in chronic 

uremia (human, rats) 
ROlHL-16918-05 Role of steroids in hypertension (human) 
POIHL- 174 19-04 0006 Studies on mechanisms of 
hemostasis - Effect of hormones, drugs and other agents 
on fibrinogen synthesis (chick) 
R01HL17458-04 Renal control of sodium excretion (rats) 
ROlHL-1818104 Surfactant metabolism-Alveolar cells and 

lung disease (mice, rabbits) 
ROlHL-19072-03 Modification of tissue injury in 

myocardial infarction (dogs, human) 
R01HL-19n5-02 Hormonal control of tracheobronchial 
cyclic AMP (rats, guinea pigs) 
" P50HL-19185-02 0005 Pulmonary SCOR -Neonatal 

respiratory distress syndromes - Role and mechanism of 
glucocorticoids in fetal lung maturation (human rabbit) 
P50HL.19I90-02 0003 Pulmonary SCOR -Pathophysiology 
management of IRDS - Type II cells -Regulation and 
differentiation (rat) 
ROlHL-19195-03 Hormonal regulation of lung function 

(rats) 
ROlHL-19673-03 Surgical aspects of shock and hypoxia 

(dogs, monkeys, rats) 
ROlHL-2019902 Drug-induced alterations in infarct size 

in the rat 
ROlHL-20283-02 Maintenance of cellular integrity in 

ischemic hearts (cats) 
ROlHL-20371-02 Intravascular redistribution of blood 

volume (dogs) 
R23HL-22972 01 Microcirculatory function in hypotension 
(rats, hamsters) 

ROlHL-231 15-01 Regulation of active sodium transport 
(frogs, rats) 

ADRENAL CORTEX HORMONES, 
HYDROCORTISONE 

POlHL-0631417 0066 Immunologic mechanisms in 

cardiovascular disease - Sensitization, cell-mediated 

cytotoxicity, role of lymphocytes (human mice) 
P0IHL06370-17 0004 Cardiopulmonary and renal 

pathology research center - Lymphocytes in graft rejection 

and immune surveillance (human) 
ROlHL-12990-09 Control of antidiuretic hormone secretion 

and metabolism (dogs. rats, rabbits) 
ROIHL 14706-07 Fetal hearts in organ culture (mice) 
R01HL15677-06 Autonomic nervous system function in 

bronchial asthma (human, guinea pig, rabbit) 
ROIHL 16364-04 Regulation of lipid biosynthesis and 

transport (rats, swine, Xenopus) 
ROlHL-17719-03 Lung iniury, substrate utilization oxygen 

toxicity (rats, rabbits dogs) 
P50HL-1832304 0038 SCOR hypertension center ■ 

Unknown adrenocortical mechanisms in hypertension 

(human) 
ROlHL-18537-04 Regional blood flow after acute 

myocardial injury (dogs) 
POIHL 18575-03 0001 Mechanisms of vascular changes 

in hypertension - Arteries and resistance vessels in 

hypertension (pigs, rats) 



ADR 

ROlHL-19115-02 Hormonal control of tracheobronchial 

cyclic AMP (rats, guinea pigs) 
P50HL-19185-02 0005 Pulmonary SCOR -Neonatal 

respiratory distress syndromes - Role and mechanism of 

glucocorticoids in fetal lung maturation (human rabbit) 
ROlHL-19721-03 Lung inflammation -Lysosomal' proteases 

and liposomes (human, rabbits) 
" POlHL-19737-02 0003 Cellular and molecular aspects of 

respiratory physiology - Cortisol-dependent alterations in 

lung type II cells (rats) 
ROlHL-19752-03 Phospholipid synthesis by fetal lung in 

organ culture (rats) 
ROlHL-20364-01 Episodic hypertension associated with 

human behavior (air traffic controllers) 
ROlHL-20719-02 Cold induced pulmonary hypertension 

(cattle) 
ROlHL-20783-02 Airway reactivity-B-adrenoceptors and 

prostaglandins (guinea pigs) 
R23HL-21917-01 Adrenal steroids in adolescent and adult 

hypertension 

ADRENAL CORTEX HORMONES, 
MINERALOCORTICOIDS 

ROlHL-00759-29 Regulation of electrolyte and acid base 

equilibrium (dogs) 
ROlHL-06975-18 Pathogenesis and prevention of 

hypertension (rats) 
R01HL-0991M2 Hormonal and dietary modification of 

NaCl toxicity (rats) mice) 
ROIHL 11046-12 Renin, angiotensin, steroids. Ions and 

blood pressure (human, sheep, rabbits) 
POlHL-11414-11 0014 Thrombosis and atherosclerosis 

program ■ Role of adrenal in human essential hypertension 
ROlHL-14133-08 Intrarenal regulation of sodium 
reabsorption (dogs, hamsters, rats) 
** P50HL-14159-08 0020 Specialized center of research in 
hypertension - Renin mineralocorticoid system in 
hypertension (human, rat, dog) 
" P50HL-14192-08 0007 Specialized center of research in 
hypertension - Role of new mineralocorticoids in 
hypertension (human, rats) 
ROlHL-16658-05 Intrarenal regulation of sodium 

reabsorption 
R01HL16918-05 Role of steroids in hypertension (human) 
R01HL1745804 Renal control of sodium excretion (rats) 
ROlHL-1774903 Adrenocortical factors in human 

hypertension (human) 
R01HL18185-04 Cardiac glycosides and diuretics -Role of 
NaO pump (dogs) 
M P50HL-18318-03 Pathogenesis and complications of 
hypertension 
P50HL-1831803 0001 Pathogenesis and complications of 
hypertension - Core clinical program 
** P50HLI8318-03 0004 Pathogenesis and complications of 
hypertension ■ Steroid and renin profiles in hypertension 
(rats, human) 
P50HL 1831803 0007 Pathogenesis and complications of 
hypertension ■ Humoral factors and renal function in 
experimental hypertension (rats) 
" P50HL-1831803 0009 Pathogenesis and complications of 
hypertension - The mineralocorticoid-hypertensive syndrome 
in man 
" P50HL18318-03 0010 Pathogenesis and complications of 
hypertension - Hemodynamics in mineralocorticoid and low 
renirr hypertension (human) 
P50HL-18318-03 0011 Pathogenesis and complications of 

hypertension - Adrenergic function -Renin and 
mineralocorticoid activity (human) 
P50HL-18323-04 0037 SCOR hypertension center - 

Adrenocortical factors in childhood hypertension 
P50HL-18323-04 0038 SCOR hypertension center ■ 
Unknown adrenocortical mechanisms in hypertension 
(human) 
POIHL-18575-03 0002 Mechanisms of vascular changes 
in hypertension Endocrines, electrolytes, and 
hemodynamics in hypertension (pigs) 
ROlHL-18579-03 Vasoactive hormones and blood pressure 

regulation (dogs. rats, rabbits) 
ROIHL-18730-03 Role of mineralocorticoids in low renin 
hypertension (human, rats) 
** R01HL19279-03 Intracellular action of aldosterone in 
hypertension (human, rats) 
R01HL19644-03 Etiological factors in hypertension 

(human, dogs, rats) 
ROlHL-20201-01 Hypertension and vascular steroid 

receptors (rats) 
ROlHL-21 112-02 Aldosterone binding, clearance, and 

secretion in man 
ROlHL-21272-02 Sodium homeostasis and renal 

prostaglandins (dogs) 
R23HL-21291-02 Renin-mineralocorticoid axis in 

hypertensive diabetics (human) 
ROlHL-2177901 Steroids in adrenal regeneration 

hypertension (rats) 
ROlHL-22617-01 Angiotensin, hypertension and the CNS 
(sheep) 

ADRENAL CORTEX HORMONES, 4-PREGNENE- 
1 1 BETA,I8,21-TRIOL-3,20-DIONE 

SEE ALSO ADRENAL CORTEX HORMONES ALDOSTERONE 
P50HL-18323-04 0038 SCOR hypertension center - 
Unknown adrenocortical mechanisms in hypertension 
(human) 



I 



i 



;Excludes toutme metliodology OR covers only general proiects which preclude indexmi. 
Unented significantly lo above sub|ccl 



at the specific level. 



M Grant has subproiects describing specific research aspects. 
See Appendix for investigators name and grant number. 



(contd) 



ADR 

KOIHl .'01 /B O:' Biochemistry and |«n«tics ol s«ll 
hypotension (lats) 
ADRENAL CORTEX HORMONES ANALOGS, 
DEXAMETHASONE 

COim iii.m'> 1 ' OOM) Cjidiovascular disease 18 
Hviliinyi.iM' bio. k in tite \l liphi hydtoiylase deficiency 

sylulliHlU' (tuim.nll 

(?01HL llU4b I.' Kenin. «n|iotensin, steroids, ions and 

blood pressure (human, sheep, rabbits) 
POIHI 11414 11 0014 Thrombosis and atherosclerosis 

program Role ol adrenal in human essential hypertension 
ROIHI 1643/ Ob Diui! treatment ol atherosclerosis 

(rabbits, monkeys) 
ROIHL 17458 04 Renal control ol sodium excretion (rals) 
ROIHI 17705 04 Kallikrein kinin system in hypertension 

(human, rats, dogs) 
ROIHL 1774903 Adrenocortical factors in human 

hyparlension (human) 
P50HL 18323 04 0037 SCOR hypertension center 

Adrenocortical factors in childhood hypertension 
ROIHI 1873003 Role of mineralocorticoids in low renin 

hypertension (human, rats) 
ROIHL 18923 02 Steroid induced hyperlipidemia and 

hypertension (human, rats) 
ROIHL 1923703 Obstructive lung disease and alveolar 
macrophages (human, animals) 
ADRENAL CORTEX HORMONES ANALOGS, 
FLUDROCORTISONE 

P01HL14388 07 0229 Regulation ol the circulation in 
pathological states Mechanism ol postural hypotension 
(human) 
ADRENAL CORTEX HORMONES ANALOGS, 
METHYLPREDNISOLONE 
POlHL-06312 17 0018 Surgical cardiology - Cardiac 

transplantation growth (calves) 
R01HL08696 15 0012 Orthotopic heart transplantation - 
Transplantation immunology -Modulation of donor 
antigenicity (dogs) 
R01HL0869615 0013 Orthotopic heart transplantation ■ 
Transplantation immunology -Cardiac heterotransplantation 
(rabbits, dogs) 
POIHL 13108-09 0001 Clinical heart transplantation - 

Therapy and prognosis (human) 
ROlHL-17479-04 Blood storage -The production of 

cardiotoxic material (dogs, human, swine) 
R01HL1892302 Steroid induced hyperlipidemia and 

hypertension (human, rats) 
R01HL19072-03 Modification of tissue injury In 

myocardial infarction (dogs, human) 
P50HL1915302 0003 SCOR -Pulmonary edemas-Eitology. 
pathogenesis - Possible inhibitors of mediator release and 
pulmonary vascular response (sheep) 
R01HL-21G8402 0002 Radionuclide infarct sizing and 
therapy evaluation - Evaluating myocardial imaging agents 
in global and regional ischemia (rabbits) 
R23HL-2289501 Smoke Inhalation -Biochemical and 
cellular responses (rabbits, bacteria) 

ADRENAL CORTEX HORMONES ANALOGS, 
PREDNISONE 

POlHL-13108-09 0014 Clinical heart transplantation 

Platelets and coagulation In accelerated graft coronary 

atherosclerosis 
POlHL-17813-04 0001 Lung disease and the oxygenation 

of blood and tissue - Diffuse interstitial lung disease- 

Pathophysiology (human, dogs) 
ROlHL-18923-02 Steraid-induced hyperlipidemia and 

hypertension (human, rats) 
ADRENAL CORTEX (HORMONES) INHIBITORS 

SEE ALSO ADRENAL CORTEX HORMONES. ALDOSTERONE 

INHIBITORS 
POlHL-11414-11 0014 Thrombosis and atherosclerosis 

program - Role of adrenal in human essential hypertension 
ROlHL-19209-03 Role of ADH in experimental renal 

hypertension (dogs, rats) 

ADRENAL GLANDS 

SEE ALSO ADRENAL MEDULU 
SEE ALSO PITUITARY-ADRENAL AXIS 
ROlHL-02033-23 Regulation of cholesterol esters In blood 

and tissues (rat. cattle, human) 
ROlHL-02363-20 Kinetics of water and electrolytes in 

shock (dogs, rats) 
POlHL-06835-17 0055 Cardiovascular disease - Vascular 

and adrenocortical response to angiotensin II (dogs) 
POlHL-06835-17 0056 Cardiovascular disease - 

Angiotensin analogs -Sarcosine on arterial pressure, 

aldosterone (dogs) 
ROlHL-09921-13 Mechanisms related to congestive heart 

failure (dogs, human, rat) 
ROlHL-10942-09 Study of genetic hypertension in rats 
ROlHL-12677-10 Surgical physiologic studies of Isolated 

kidneys (dogs, rats) 
ROlHL-17847-04 Cardiovascular and renal functions of 

marmots 
** P01HL-18974-03 0010 Experimental neurogenic 

hypertension program - Biochemistry and regulation of 

PNMT In brain (rats) 
ROlHL-20061-02 Serum lipoproteins and cell cholesterol 

metabolism (rats, human) 



•• ('01 HI 20948 02 000? Molecular basis ol cholesterol 

metabolism 101 pathwiiy in cell lines wilfi intormalive 
properties other Ih.in fibiobl.nls 

•* ROIHI 22990 01 AngiulrnMn II receptors Mechanisms ol 
reguliilion (rats) 

ADRENAL GLANDS DISORDERS 

Sll AlSOUIStASfS SIGNS SYMi'IOMS, HIRSUIISM 

SEi AlSOMtlAHOlIC DISORD! RS INBORN. IIPID (NfUTRAl) 

STORACf WOl MAN'S DISEASE 
SEE Also NfOPlASMS Of [NDOCRINfS ADRENAl GUNDS 
NEOPLASMS 
*• POIHI 06370 17 0015 Cardiopulmonary and renal 
pathology research center Pathogenesis of chemically 
induced tissue iniury (rats) 
•• POlHt 06835 17 0050 Cardiovascular disease 18 
Hydroxylase block in the 17 alpha hydroxylase deficiency 
syndrome (human) 
ROIHL 21272 02 Sodium homeostasis and renal 

prostaglandins (dogs) 
ROIHL 22506 01 Hemodynamics of the clinical 
hypertensions 
ADRENAL GLANDS DISORDERS, ADDISON'S 
DISEASE 

ROIHL 11046 12 Renin, angiotensin, steroids, ions and 
blood pressure (human, sheep, rabbits) 

ADRENAL GLANDS DISORDERS, ADRENAl 
HYPERTENSION 

SEE ALSO ADRENAL GLANDS DISORDERS. 

HYPERALDOSTERONISM 
SEE ALSO KIDNEY CIRCULATORY DISORDERS, RENAL 

HYPERTENSION 
SEE ALSO KIDNEY CIRCUUTORY DISORDERS, RENOPRIVAL 
HYPERTENSION 
** POlHL-06835-17 0047 Cardiovascular disease ■ 
Spironolactone in primary aldosteroidism (human) 
POlHL-06835-17 0048 Cardiovascular disease - 
Aldosterone producing adenoma prediction of curability 
(human) 
** ROlHL-06975-18 Pathogenesis and prevention of 

hypertension (rats) 
** ROlHL-09911-12 Hormonal and dietary modification of 
NaCl toxicity (rats) mice) 
ROlHL-10942-09 Study of genetic hypertension in rats 
** ROlHL-11046 12 Renin, angiotensin, steroids, ions and 
blood pressure (human, sheep, rabbits) 
POIHL-11414-11 0014 Thrombosis and atherosclerosis 

program - Role of adrenal in human essential hypertension 
ROlHL-13408-05 Enviranmental-genetic Interactions in 

hypertension (rats) 
ROlHL-13917-20 Secretion and effects of adrenal 
hormones (human, rabbits, sheep) 
*" ROlHL-13936-06 Microvascular responses in hypertension 
(human, rats) 
P50HL-14159-08 0020 Specialized center of research in 
hypertension - Renin-mineralocorticoid system in 
hypertension (human, rat, dog) 
P50HL-14159-08 0021 Specialized center of research in 
hypertension - Genetic studies of the physiology of 
hypertension (human, rats) 
P50HL-14159-08 0024 Specialized center of research in 
hypertension - Core resources (clinical, animal models) 
** P50HL-14192-08 0007 Specialized center of research in 
hypertension - Role of new mineralocorticoids In 
hypertension (human, rats) 
ROlHL-15839-05 Physiological role of isorenin and 
kallikrein (animals) 
•* ROlHL-17458-04 Renal control of sodium excretion (rats) 
ROlHL-17749-03 Adrenocortical factors in human 
hypertension (human) 
" ROlHL-18102-02 Role of the adrenal cortex in human 
hypertension 
P50HL-183 18-03 0002 Pathogenesis and complications of 
hypertension ■ Core experimental animal facility (rats, 
rabbits) 
** P50HL-18318-03 0004 Pathogenesis and complications of 
hypertension - Steroid and renin profiles in hypertension 
(rats, human) 
P50HL-18318-03 0007 Pathogenesis and complications of 
hypertension - Humoral factors and renal function in 
experimental hypertension (rats) 
M P50HL-18323-04 SCOR hypertension center 
*• P50HL-18323-04 0037 SCOR hypertension center - 

Adrenocortical factors in childhood hypertension 
** P50HL-1832304 0038 SCOR hypertension center - 
Unknown adrenocortical mechanisms in hypertension 
(human) 
P50HL-18323-04 0044 SCOR hypertension center - 
Angiotensin blockade to Identify angiotensin II factor in 
hypertension (human) 
** POlHL-18575-03 0002 Mechanisms of vascular changes 
in hypertension - Endocrines, electrolytes, and 
hemodynamics in hypertension (pigs) 
** POlHL-18575-03 0010 Mechanisms of vascular changes 

in hypertension - Hypertensive pig Core 
** ROlHL-18579-03 Vasoactive hormones and blood pressure 

regulation (dogs, rats, rabbits) 
" ROIHL 18893-03 Mechanism of angiotensin action -Role of 

receptor (rats) 
*• ROIHL 19027-03 Calcium and cyclic AMP in causation of 
hypertension (rats) 



AUK 

•• ROIHI 14144 0) Conlrictplivt Ittroidl ind tipjrrrrnntal 

hypertenMun (rati) 
*• ROIHI 19209 01 Role ol AOH in txptrimtntil rtnd 
hyperteuMon (dugs, rati) 
NOIHI 19174 03 Pharmacology of kinini in citdioviKUlir 
disease (rat',. rabbil%) 
•■ ROIHI 19644 03 tliologir.al laclor-. in hypertension 
(human dog-, rals) 
ROIHL 201/6 02 Biochemistry and genetics ol •,all 
hypertension (rals) 
•* ROIHI 20201 01 Hypertension and vascular steroid 

receptors (rals) 
•• ROIHI 20384 09 Social stimulation, RNA and 

cardiovascular disease (animals) 
** ROIHI 20604 03 Sympathectomy Cardiovajcular and 
molecular pharmacology (animals) 
ROIHI 2130/ 01 Risk reduction and exercise fitnesj in a 
population 
" ROIHL 21498 02 Pathophysiology of edema (rats, calj) 
•* ROIHL 21//9 01 Steroids in adrenal regeneration 

hypertension (rats) 
** ROIHL 2187701 Iso renins In the hypertensive rat 
*" R23HL 21914 01 Studies of vasomotor control (rats) 

ADRENAL GLANDS DISORDERS, 

HYPERADRENALISM, CUSHING'S SYNDROME 

POIHL 11414 11 0014 Thrombosis and atherosclerosis 

program Role of adrenal in human essential hypertension 

ROIHL 13595-08 Renin and vascular hyper reactivity in 
hypertension (human, rats) 

ADRENAL GLANDS DISORDERS, 
HYPERALDOSTERONISM 

SEE ALSO ADRENAL CORTEX HORMONES. ALDOSTERONE 
SEE ALSO CARDIOVASCULAR DISORDERS. HYPERTENSION 

(SYSTEMIC). ANGIOTENSIN RENIN ALDOSTERONE- 
ASSOCIATEO 
POlHL-06835 17 0045 Cardiovascular disease Pressure 
volume-renin relationship In human hypertension 
*♦ P01HL06835 17 0047 Cardiovascular disease - 
Spironolactone in primary aldosteroidism (human) 
POIHL 06835-17 0059 Cardiovascular disease 

Metyrapone-induced hypertension in dog 
ROIHL 10612-13 0018 Humoral factors in heart failure 
and hypertension - The pathogenesis of experimental renal 
hypertension (dogs, rabbits, rats) 
** ROlHL-10914-10 Renal sodium transport in experimental 

aldosteronism (dogs) 
** ROlHL-11046 12 Renin, angiotensin, steroids, ions and 
blood pressure (human, sheep, rabbits) 
POIHL 11414 11 0014 Thrombosis and atherosclerosis 

program - Role of adrenal in human essential hypertension 
ROIHL-13595-08 Renin and vascular hyper- reactivity in 

hypertension (human, rats) 
ROIHL 13917-20 Secretion and effects of adrenal 

hormones (human, rabbits, sheep) 
P50HL-14159-08 0020 Specialized center of researoh in 
hypertension - Renin mineralocorticoid system In 
hypertension (human, rat. dog) 
P50HL-14159-08 0021 Specialized center of researoh in 
hypertension - Genetic studies of the physiology of 
hypertension (human, rats) 
P50HL-14159 08 0024 Specialized center of research in 

hypertension - Core resources (clinical, animal models) 
ROIHL-16918-05 Role of steroids in hypertension (human) 
ROlHL-17458-04 Renal control of sodium excretion (rats) 
ROlHL-17705-04 Kallikrein-kinin system in hypertension 

(human, rats, dogs) 
ROlHL-1774903 Adrenocortical factors in human 

hypertension (human) 
P50HL-I83 18-03 0009 Pathogenesis and complications of 
hypertension - The mineralocorticoid-hypertensivc syndrome 
in man 
*• P50HL 18318-03 0010 Pathogenesis and complications of 
hypertension - Hemodynamics in mineralocorticoid and low 
renin hypertension (human) 
P50HL-1832304 0042 SCOR hypertension center - Blood 
viscosity and blood volume In hypertensive disease 
(human, dog) 
P50HL-I8323-04 0044 SCOR hypertension center - 
Angiotensin blockade to identify angiotensin II factor in 
hypertension (human) 
ROlHL-18624-03 Study of kinins In hypertension and other 

diseases (human) 
R23HL-21066-02 Angiotensin and prostaglandin control of 

aldosterone (rats) 
ROIHL-21274-01 Prorenin-Physiological and biochemical 

analysis (human) 
ROlHL-21525-02 Effect of cations, anions and water upon 

blood vessels (dogs, rats) 
R0IHL-232O1-0I Mechanisms of hypertension (human, 
rats) 
ADRENAL GLANDS DISORDERS, 
HYPOALDOSTERONISM 
SEE ALSO METABOLIC DISORDERS INBORN, BARHER'S 
SYNDROME 
*' POlHL-06835-17 0049 Cardiovascular disease Selective 
hypoaldosteronism (human) 

(contd) 



•Excludes routine mctliodology OR covers only general projects which preclude indexing at the specific level 
"Oriented significantly to above subject 



M Grant has subproiects describing specific research aspects 
See Appendix for investigator s name and grant number 



ADR 

ADRENAL GUNOS DISORDERS, 

HYPOAIDOSTERONISM, HYPORENINEMIC 

POlHL-0683517 0059 Cardiovascular disease - 

Metyrapone-induced hypertension in dog 
ROlHL-1104612 Renin, angiotensin, steroids, ions and 

blood pressure (human, sheep, rabbits) 
ROIHLI 736404 'Big renin' -Biochemical and clinical 

studies (human) 

ADRENAL GLANDS NEOPLASMS 

SEE NEOPUSMS OF ENOOCRINES. ADRENAL GUNOS 
NEOPLASMS 

ADRENAL HYPERTENSION 

SEE ADRENAL GUNDS DISORDERS. ADRENAL HYPERTENSION 
ADRENAL MEDULU 

R01HL13666-06 Pharmacology of genesis of cardiac 

rhythmicity (rats, cats) 
ROlHL-18148-04 Adrenal catecholamine secretion 
ROlHL-18995-04 Cardiovascular determinants of 

catecholamine release (dogs) 
ROlHL-2167001 Antiarrhythmic studies on 2-subsfituted 

aminoindenes (dogs) 
ROlHL-2217001 Factors influencing transmission at 

adrenergic synpases 

ADRENAL MEDULLA HORMONES 

SEE ALSO PHENYULKYLAMINES, CATECHOUMINES 

EPINEPHRINE 
SEE ALSO PHENYULKYUMINES. CATECHOUMINES 
NOREPINEPHRINE 
R01HL1860101 Regulation of neurotransmitter release bv 
adenosine (rats) 

ADRENALECTOMY 

POlHL-06835-17 0031 Cardiovascular disease - Synthesis 
of potent antagonist of pressor action of angiotensin II 
(animals) 
POlHL-06835-17 0047 Cardiovascular disease ■ 
Spironolactone in primary aldosteroidism (human) 
ADRENALIN OXIDASE 

SEE OXIDOREDUCTASES. AMINE OXIDASE (FUVIN 
CONTAINING) 

ADRENALINE 

SEE PHENYULKYUMINES, CATECHOUMINES, EPINEPHRINE 
ADRENERGIC AGENTS 

SEE NEUROPHARMACOLOGICAL AGENTS, SYMPATHOMIMETIC 
ADRENERGIC BLOCKING AGENTS 

SEE NEUROPHARMACOLOGICAL AGENTS. SYMPATHOLYTIC 
ADRENERGIC ALPHA RECEPTOR AGENTS 

SEE NEUROPHARMACOLOGICAL AGENTS. SYMPATHOMIMETIC 
ADRENERGIC ALPHA 

ADRENERGIC BETA RECEPTOR AGENTS 

SEE NEUROPHARMACOLOGICAL AGENTS, SYMPATHOMIMETIC 
ADRENERGIC BETA 

ADRENERGIC ALPHA RECEPTOR BLOCKING 
AGENTS 

SEE NEUROPHARMACOLOGICAL AGENTS, SYMPATHOLYTIC 
ADRENERGIC ALPHA 

ADRENERGIC BETA RECEPTOR BLOCKING 
AGENTS 

SEE NEUROPHARMACOLOGICAL AGENTS, SYMPATHOLYTIC 
ADRENERGIC BETA 

ADRENERGIC RECEPTORS 

SEE NEUROTRANSMITTERS RECEPTORS ADRENERGIC 
RECEPTORS 

ADRENERGIC ALPHA RECEPTORS 

SEE NEUROTRANSMinERS RECEPTORS ADRENERGIC 
RECEPTORS, ALPHA RECEPTORS 

ADRENERGIC BETA RECEPTORS 

SEE NEUROTRANSMinERS RECEPTORS ADRENERGIC 
RECEPTORS. BETA RECEPTORS 

ADRENOCORTICOTROPIC HORMONE 

SEE PITUITARYDIENCEPHALON HORMONES. ACTH 
ADRIAMYCIN 

SEE ANTIBIOTICS, ADRIAMYCIN 
ADSORPTION 

SEE PHYSICAL PROPERTIES, ADSORPTION 
ADULT ANIMAL 

SEE AGE (ANIMAL), MATURE (ADULT) 
ADULTS 

SEE AGE (HUMAN), ADULT 
AEROBES, BACTERIAL 

SEE MICROORGANISMS, AEROBES 
AEROBIC MICROORGANISMS 
SEE MICROORGANISMS. AEROBES 
AEROBIOSIS 

SEE RESPIRATION INTERNAL, AEROBIOSIS 

••nnpSf.Vc"""f "'".'?''?<"<'« O" "«'5 ""I* general proiecis which preclude indexing 
Oriented signihcantly to above sub/eel. 



AEROSOL AND PARTICLE BEAMS 

SEE PHYSICAL PROPERTIES, AEROSOL AND PARTICLE BEAMS 
AEROSOL THERAPY, RESPIRATORY DISORDERS 

SEE RESPIRATORY ASSIST AND OXYGEN ADMINISTRATION 
AEROSOL THERAPY 

AEROSOLS 

SEE PHYSICAL PROPERTIES. AEROSOLS 
AFFECT 

SEE PSYCHOLOGY. EMOTIONS 
AFFECTIVE DISORDERS 

SEE PSYCHOLOGY ABNORMAL. EMOTIONAL DISORDERS 
AFFERENT NERVES 

SEE NERVOUS SYSTEM, AFFERENT NERVES 
AFFINITY CHROMATOGRAPHY 

SEE PHYSICAL SEPARATION, CHROMATOGRAPHY. AFFINITY 
AFIBRINOGENEMIA 

SEE BLOOD COAGUUTION DISORDERS, AFIBRINOGENEMIA 
AFRICA 

SEE GEOGRAPHICAL SITES, AFRICA 
AFRO AMERICANS 

SEE SOCIAL GROUPS, ETHNIC, AMERICANS BUCK 
AMERICANS 

AFTER CARE (POST-HOSPITALIZATION) 

SEE HEALTH CARE SERVICES, PATIENT CARE POST- 
HOSPITALIZATION CARE 

AGE (ANIMAL) 

ROlHL-08359-14 Morphopharmacology of vascular 

adrenergic transmission (rabbits rats) 
POlHL-0880515 0039 Regulation of ventilation and 

pulmonary circulation Carotid body (cats) 
ROlHL-09234-13 Amino acids of contractile proteins of 

failing hearts (dogs, hamsters) 
ROlHL-1061213 0019 Humoral factors in heart failure 
and hypertension - Pathogenesis of hypertension in the 
spontaneous hypertensive rat 
POIHL 1 131012 0089 Mechanisms of cardiovascular 
disease ■ Structure and function in myocardial contraction 
(dogs) 
P01HL1131012 0106 Mechanisms of cardiovascular 
disease Biochemical characterization of the collagens in 
vascular tissue (catte) 
POlHL-1237310 0005 Cardiopulmonary physiology and 
pathophysiology ■ Characterization of fetal and neonatal 
myocardium (human, cats) 
POlHL-12738-10 0108 Physiologic pharmacology and its 
clinical applications ■ Developmental electrophysiology and 
pharmacology (human, animals) 
P01HL12738-10 0134 Physiologic pharmacology and its 
clinical applications ■ Adenylate cyclase and cAMP 
phosphodiesterase in cardiac development (dogs) 
POlHL-1438807 0168 Regulation of the circulation in 
pathological states - Ionic basis of depolarization (rats 
tissue culture) 
R01HL1452607 Oral contraceptives and hypertension 

(rats) 
ROlHL-1544406 Neonatal development of adrenergic 

receptor mechanisms (pigs) 
R01HL-I5837-06 Renin and cardiac hypertrophy in 

hypertension (rats) 
R01HL15840-02 Sugar-induced heart lesions and vitamin 

K deficiency (birds, mammals subhuman) 
ROlHL-16420-02 Effect of training-detraining on the rat 

heart 
ROlHL-16454-03 Vascular muscle reactivity in 

hypertension (human, rats) 
POlHL-16748-05 0004 Cellular and immunological basis 
of pulmonary diseases ■ Cellular and immunological 
processes in pulmonary defense systems 
ROlHL-17322-04 Functional characteristics of smooth 

muscle isolated from lung (animals) 
R01HL-I7768-04 Development of collateral ventilation 

(dogs, fish, horses) 
ROlHL-17776-04 Pulmonary mucus transport in 

obstructive lung diseases (human) 
ROIHL-1800203 Circulatory shock, trauma and RE-system 

function (rats) 
ROlHL-19056-03 Blood triglycerides and lipoprotein lipase 

in the lung (rats) 
ROlHL-19225-02 0002 Types and mechanims of 
pulmonary hypertension - Effect of aorto-pulmonary shunt 
(pigs) 
ROIHL 19741-03 Murine CRD--A model of chronic 

pulmonary inflammation (mice, rats) 
R01HL-20170-02 Pulmonary infection in splenectomized 

animals (mice) 
POlHL-20552-02 0002 The development and regression of 
cardiac hypertrophy Effect of treatment on the 
hypertrophied left ventricle (rats) 
ROlHL-20572-02 0007 Hemodynamic relations to 
metabolism in hypertension - Drug effects on cardiac 
function and hypertropy (rats) 
POlHL-20581-01 0002 Vascular neuroeffector 
mechanisms in health and disease - Trophic interaction 
between adrenergic nerves and vascular smooth muscle 



at the specific level 



M Grant has subprojects describing specific research aspects 
Sec Appendix for investigator's name and grant number 



AGE 

POlHL-20581-01 0005 Vascular neuroeffector 
mechanisms in health and disease ■ Changes in the 
neuroeffector mechanism in hypertension (rabbits) 

POl HL-20581-01 0006 Vascular neuroeffector 
mechanisms in health and disease - Neuroeffector 

Pom^lTo^no^a^^"' '"."/''"' '" hypertension (human) 
POlHL-20592-02 0010 Cell biology of cardiac and 

skeletal muscle ■ Mitochondrial genesis during myocardial 

cell hypertrophy and hyperplasia (rats) 
ROlHL-20749-01 Developing heart -Biophysical aspects 

(sheep) "^ 

ROlHL-21099-02 Subcellular changes of blood vessels in 

hypertension (rats) 
ROlHL-21245-02 Influence of chronic exercise on 

hypertension (rats, primates) 
ROlHL-21632-02 Development of a transcutaneous power 

transfer system (cattle) 
ROlHL-22226-01 Autonomic nervous elements in the 

developing heart (rabbits) 
ROlHL-22924-01 The airway mucosal barrier (guinea pigs) 
ROIHL 23025-01 Adaptive heart growth in neonates and 

adults (rats) 
ROlHL-23980-01 Effects of digoxin therapy in newborn 

and adult sheep 

AGE (ANIMAL), IMMATURE 

POlHL-14388-07 0193 Regulation of the circulation in 

pathological states Ontogenesis of central nervous system 

amines in hypertension (rats) 
ROlHL-18082-03 Erythrocyte phosphates and vertebrate 

gas transport (amphibians, reptiles) 
R23HL 22309-01 Cardiovascular pharmacodynamics in 

immature dogs 

AGE (ANIMAL), lAAMATURE, LARVA 

POlHL-07896-15 0060 Environmental biomedical research 
program - Effect of pressure on development of marine 
crustacean larvae 

AGE (ANIMAL), INFANTS 

POlHL-06312-17 0018 Surgical cardiology - Cardiac 

transplantation growth (calves) 
POlHL-11307-12 0002 Biophysical studies In pediatric 
cardiology Cardiac extracellular electrophysiology (human, 
dog, chimpanzee) 
ROIHL 12827-08 Regulation of sodium excretion (dogs 

rats) 
POl HL-13480-09 0026 Cardiac electrophysiology - Neural 
influences on cardiac electrophysiology and contraction 
(dog, cat) 
ROlHL-13666-06 Pharmacology of genesis of cardiac 

rhythmicity (rats, cats) 
P50HL-14164-07 0041 A/S SCOR-Comparative and 
experimental atherosclerosis - Nonhuman primate pediatric 
atherosclerosis risk factor 
ROlHL-15797-05 Lipid metabolism and atherosclerosis in 
primates (monkeys, human squirrels) 
" R01HL-16292-05 0019 Surgeiy and non-obstructive 

coronary insufficiency - Distortion of subendocardial vessels 
in infant hearts (dogs) 
R01HL-190I0-03 Metabolism and cell biology of lung 
surfactant system (rabbits sheep) 
" P50HL-19362-02 0001 A/S SCOR -Atherosclerosis in 
nonhuman primates - Effects of infant nutrition on 
atherosclerosis (baboons) 
** P50HL-19362-02 0002 A/S SCOR-Atherosclerosis in 

nonhuman primates ■ Infant caloric intake, adipose tissue 
development and atherosclerosis (baboon) 
ROlHL-19779-03 Biochemical basis of oxygen damage to 

lung cells (guinea pigs, rats) 
ROIHL-20548-02 Innervation of the lung (rats, monkeys) 
ROlHL-21872-01 Myocardial perfusion In the hypertrophied 

heart (dogs) 
R01HL-23601-01 Early hypoxia and development of 
respiratory control 

AGE (ANIMAL), INFANTS, BIRTH WEIGHT 

SEE ALSO AGE (ANIMAL), INFANTS PREMATURE AND LOW 
BIRTH WfEIGHT 
ROlHL-19352-03 Respiratory heat and water loss in 
neonates 

AGE (ANIMAL), INFANTS MORTAUTY 

ROlHL-19651-03 Host factors in pathogenesis of 
respiratory disease (human, hamsters) 

AGE (ANIMAL), INFANTS NEWBORN 

N01HB-4297M2 Chimpanzees for hepatitis research 
ROlHL-01755-25 Fetal and neonatal cardiovascular 

function (sheep) 
ROlHL-02888-22 Interrelationships of circulation and 
respiration (opossum cats) 
** POl HL-06285-18 0125 Cardiovascular-respiratory 

physiology and biochemistry - Myocardial function in the 
fetal and neonatal lamb 
" POlHL-06285-18 0129 Cardiovascular-respiratory 

physiology and biochemistiy - Pulmonary microcirculation in 
the fetus and neonate (lambs) 
ROlHL-08659-14 Myocardial performance and metabolism 

in the newborn (sheep) 
POlHL-10436-13 0015 A multidisciplinary study of 
congenital heart disease ■ Fetal and neonatal 
cardiovascular physiology (sheep) 
ROIHL-10942-09 Study of genetic hypertension in rats 

(conid) 



AOE 



POIHI 11310 12 0064 M»ch«nijmj ol c«idiov«itul»i 

diMisf lititcoditc tnatomical collection ol 
tiinsposition of |i«<l titeiKs (puppioil 
POIHI 11310 12 00/6 Mochsnumj ol c«i(Jioy«scul«i 
diMisa Ti»tm«nl ol dopiessed oidiac output lollowinj 
hurt aui|*ry (chiidian. puppies) 
POIHI 1215' 11 OOb? Functions and mechanisms ol cell 

mambiane ion tianspoit [lectiophysiolojical 
investijations ol synthetic stiands ol heart muscles (lats) 
' POIHI 123n 10 0005 Caidiopulmonary physiolojy and 
palhophysiolojy Chaiacteiualion ol total and neonatal 
ntyocaidium (human, cats) 
ROIHL 13237 09 [lythrocytes dutint earlv development 

(human, animals) 
P50HL U214 07 0025 Newborn lung centei lor hyaline 
membrane disease Pulmonaiy vasculat peimeabilily and 
lung watei Hyaline membcane disease (sheep) 
P50HI 14214 07 0026 Newboin lung centei loi hyaline 
membiane disease Hemodynamic studies ol HMD 
Prostaglandins production and blockers (lambs) 
P50HL 14214 07 0027 Newboin lung centei toi hyaline 

membiane disease Oial laiyngeal chemoreceplois and 
lespiiatory lailuie in newborns (human, sheep) 
P50HL 14214 07 0028 Newboin lung centei loi hyaline 
membiane disease Relationship ol tiace metals to 
respiialoiy lailure (dog, sheep, human) 
P50HL 14214 07 0029 Newboin lung centei loi hyaline 
membiane disease The diving rellex Peiinatal asphynia, 
pulmonary ischemia and HMD (sheep) 
P50HL 14214-07 0035 Newborn lung centei toi hyaline 

membiane disease Coie Animal care lacihty 
POIHL 1438807 0159 Regulation ot the circulation in 
pathological states Early drug and diet interventions and 
blood piessuie development (lats) 
POIHL 1438807 0188 Regulation ol the circulation in 
pathological states Renin angiotensin system in the sheep 
letus 
POIHL 1438807 0196 Regulation ol the circulation in 
pathological states ■ Altered vascular responsiveness in 
spontaneous hypertension (rats) 
POIHL 1438807 0197 Regulation ol the circulation in 

pathological states Altered vascular reactivity in 
pathogenesis ol spontaneous hypertension (rats) 
•* ROlHL-1466307 Pulmonary oxygen toxicity m newborn 

lung (human, mice) 
•* ROlHL-1544406 Neonatal development of adrenergic 
receptor mechanisms (pigs) 
P60HL15999-05 0019 Miami comprehensive sicKle cell 
center - Fetal-adult hemoglobin switch (mouse, monkey) 
R01HL16022-05 Determinants of the ventilatory response 

to hypoxia (goats, cats) 
POlHL-1611705 0001 Ion movements and membranes in 
cardiovascular control - Developmental studies of 
contractile cell junctions (rats, rabbits, elasmobranch) 
POlHL-16137-05 0013 Alveolar biology - Development and 
pathology of surfactant-Formation of alveolar (rabbits, 
sheep) 
** R01HL16152-06 Electrophysiology of neonatal to adult 
heart (cats, frogs, guinea pigs) 
POlHL-17430-05 0001 Control of coagulation - Porcine 
von Willebrand's disease 
♦* ROlHL-1762903 Developmental aspects of cardiovascular 
function (human, cats, rabbits) 
R01HL17800-04 Pulmonary reflexes -Central pathways 

(cats, dogs, rabbits) 
ROlHL-17865-04 Studies on aging-Effects of sex 

hormones (rats, dogs) 
ROlHL-18028-03 Absorption of nonvolatile compounds 
from the lung 
** ROlHL-18032-03 Development of normal and myopathic 

mammalian heart (hamsters) 
** ROlHL-18952-03 Metabolism in perfused fetal and 
newborn rabbit lungs 
P50HL-19185-02 0004 Pulmonary SCOR-Neonatal 
respiratory distress syndromes ■ Fluid and protein transport 
in fetal and newborn lung (sheep, rabbits) 
P50HL-19187-02 0013 Pediatric pulmonary SCOR -Hyaline 

membrane disease ■ Research resources core 

P50HL-19190-02 0006 Pulmonary SCOR-Pathophysiology, 

management of IRDS - Asphyxia-Respiratory control (dogs) 

P50HL-19190-02 0007 Pulmonary SCOR-Pathophysiology, 

management of IRDS - Asphyxia-Cerebral metabolism (dog, 

ROlHL-19333-03 Hematopoietic chimcrism (mice, monkey) 
P50HL-19362-02 0012 A/S SCOR -Atherosclerosis in 
nonhuman primates - Induction of chronic hypertension by 
salt loading (baboon) 
R01HL19486-03 Oipole moment measurement of cardiac 

mass (rabbits, pigs) • 

ROlHL-19684-03 Histotypic lung culture in circumfusion 
systems (mice) 
** POlHL-19717-02 0023 Response of the lung to injury - 

Postnatal lung development-Cells, connective tissue and 
physiology (animals) 
•* POlHL-19717-02 0024 Response of the lung to injury ■ 

Formation of lung alveoli (rats) 
** POlHL-19717-02 0025 Response of the lung to injury - 

Role of oxygen in regulation of lung growth and 
development (rats) 
•* P01HL19717-02 0026 Response of the lung to injury - 
Protein depletion and postnatal lung development (rats) 



'• POIHI 19/17 02 0027 Retponit ol the lung to iniuiy 

Hoimone control ol lung growth and development (lattl 
ROIHl 20610 02 Neive growth (actoi and obitiuclive 

caidiomyopathy (dogs) 
ROIHI 20961 02 Hemoglobin Y chain genes f volution and 

inducibility (monkeys, human) 
ROIHI 211/6 02 Phospholipid exchange proteins in lung 

tissue (lambs) 
ROIHI 21673 01 Pathophysiology ol venous changes in 

hypertension dais. labbits. human, dogs) 
R23HI 21/83 01 Ionic control ol contiaclilily in anoxic 

myocardium (rabbits, lals) 
ROIHI 22500 01 Conveision of choline to 
phosphatidylcholine in lung (labbits, pigs) 
ROIHL 22664 01 Regulation of myocaidial cell growth 

(rats, guinea pigs) 
ROIHL 22859 01 Effect of carbon monoxide on the 
developing heart (rats) 
** ROIHL 2302501 Adaptive heart growth in neonates and 
adults (rats) 
ROIHL 2373604 Sickle cell anemia and hemoglobin 
synthesis (monkeys) 
•• ROIHL 2398001 Effects of digoxin theiapy in newboin 

and adult sheep 
AGE (ANIMAl), INFANTS PREMATURE AND lOW 
BIRTH WEIGHT 
SEE ALSO PREGNANCY DISORDERS. EMBRYO FETAL GROWTH 
DEVELOPMENT DISORDERS (SEE ALSO 
APPROPRIATE SP:CIFICS) 
P50HL 14214 07 0025 Newboin lung centei foi hyaline 

membiane disease Pulmonaiy vasculai peimeabilily and 
lung water Hyaline membrane disease (sheep) 
P50HL 14214 07 0026 Newborn lung center for hyaline 

membrane disease - Hemodynamic studies of HMD- 
Prostaglandins production and blockers (lambs) 
P50HL 1421407 0029 Newborn lung centei foi hyaline 

membiane disease The diving letlex -Perinatal asphyxia, 
pulmonary ischemia and HMO (sheep) 
P50HL-142U07 0035 Newboin lung centei lor hyaline 

membrane disease Core Animal care facility 
P50HL 19185-02 0004 Pulmonary SCOR-Neonatal 

respiratory distress syndromes - Fluid and protein transport 
in fetal and newborn lung (sheep, rabbits) 
M P50HL-19187-02 Pediatric pulmonary SCOR -Hyaline 
membrane disease 
P50HL 19187-02 0001 Pediatric pulmonary SCOR -Hyaline 
membiane disease - Hyaline membrane disease-Changes 
in lung mechanics and gas exchange (monkeys) 
P50HL-19187-02 0002 Pediatric pulmonary SCOR-Hyaline 

membrane disease ■ Hyaline membrane disease -Alterations 
in surface active material (monkeys) 
P50HL-19187-02 0003 Pediatric pulmonary SCOR-Hyaline 
membiane disease Hyaline membiane disease- 
Ultiastructurc studies (monkey) 
P50HL-19187-02 0011 Pediatric pulmonary SCOR-Hyaline 

membrane disease - Effects of hypoxia and hypercapnia on 
developing nervous system (monkey, human) 
** P50HL-19187-02 0013 Pediatric pulmonary SCOR-Hyaline 

membrane disease - Research resources core 
AGE (ANIMAl), JUVENILE (POST-INFANCY TO 
PUBERTY) 

P50HL-14164-07 0041 A/S SCOR -Comparative and 

experimental atherosclerosis - Nonhuman primate pediatric 
atherosclerosis risk factor 
AGE (ANIMAL), MATURE (ADULT) 

ROlHL-222 73-01 Oral and lung absorption of nitroglycerin 
(rats) 
AGE (ANIMAL), PUBERTY 

ROlHL-22273-01 Oral and lung absorption of nitroglycerin 
(rats) 
AGE (ANIMAL), WEANLING 

ROlHL-2227301 Oral and lung absorption of nitroglycerin 
(rats) 
AGE (HUMAN) 

SEE ALSO AGE (ANIMAL) 
SEE ALSO CELL AGE 
SEE ALSO CHILDREN 
SEE ALSO EMBRYOLOGY 
SEE ALSO PREGNANCY. EMBRYO-FETUS 
SEE ALSO PREGNANCY. EMBRYO-FETUS, GESTATIONAL AGE 
POlHL-03 174-23 0006 Mechanisms of acute vascular 

reaction to injury - Atherosclerotic plaque studies using 
mosaic analysis (human) 
ROlHL-03429-18 Central nervous system and coronary 

heart disease (human) 
POlHL-063 14-17 0066 Immunologic mechanisms in 

cardiovascular disease • Sensitization, cell-mediated 
cytotoxicity, role of lymphocytes (human, mice) 
POlHL-08974-14 0028 Natural and experimental 

atherosclerosis - Geographic pathology of atherosclerosis 
and coronary heart disease (human) 
R01HL13632-08 Vascular changes in diabetes mellitus 

(human) 
POlHL-14388-07 0208 Regulation of the circulation in 

pathological states - Baroreceptor reflex function in normal 
and hypertensive man 



Af.l 

HOIMI 14414 0/ 0008 I nviionmtntil inllutnif. on 

caidwmpinloiy and cellulii function* ln.i|«tit« ot 
iwimming (human) 
ROIHI r)124 05 Caneiii ol hypfrlfn^on in unil diwaw 

(human dogtl 
ROIHI 15808 06 Role ol »n|iottniinoitn in hyptrteniion 

and stroke (human, iibbitt) 
POIHI 1583? 06 0004 Chemical stiuttuial piedupotilioni 

to lung iniury Proteolytic activity leucocyte* m patient* 
with obstiutlive lung di*ea*e 
POIHI 16118 06 0003 Study of emphyiema Degradation 

ol collagen and elastin (human, hamitei*. mice) 
ROIHI 16588 05 Collagen lyntheji* in atheio»ti«io«it 

(dogs. lals. labbils, human) 
P60HI 1/292 04 0003 Veimont Lung Centei Subclinical 

pulmonary disease in a luial environment (numan) 
ROIHI 1/408 03 Fiesh blood ihcology Relation to 
cardiovascular risk (human) 
• POIHI 1/419 04 0003 Studies on mechanisms of 

hemostasis Chaiacteri/alion of fibrinogen (human) 
ROIHI 17732 03 Peripheral venomotoi control in Iheimal 

stiess (human! 
ROIHL 18692 03 Glycosaminoglycans and lipoproteins ot 

human plasma 
ROIHL 1880504 0007 Sudden cardiac death and the 
onset ol myocardial infaiclion Analysis of pathologic 
factois involved in sudden death (human) 
ROIHL 19869 03 Antecedents of adolescent hypertension 

(human) 
ROIHL 1987003 Hypertensive progeny-Physical and 

humoial piecursor search 
ROIHL 19898 03 Oesferrioxamine therapy in thalassemia 

(dogs, rats, children) 
ROIHL 19929 03 High blood piessuie in the young, 

prevalence and precursors (human) 
ROIHL 20179 02 Epidemiology of sudden cardiac death 

among women 
ROIHL 20381 03 Long term study ol diabetic vascular 

disease (human) 
ROIHL 20471-03 Atherosclerosis and diabetes mellitus 

(human) 
ROIHL 2101002 Glycemia. other traits and CV death in 

40.000 persons 
ROlHL-21352-02 Community studies of obstructive lung 

disease (human) 
ROlHL-21548-01 Pathogenesis of pulmonary 
thromboembolic disease (human, mammals) 
ROlHL-22739-01 Evolution and progression of pediatric 

atherosclerosis 
ROlHL-22809-01 Coronary-prone behavior and 

cardiovascular reactivity (human) 
ROIHL 23600 01 Ions, water, and hypertension (human, 

dogs, rats) 
ROlHL-23631-01 Immunogenetic factors in allergic 

respiratory diseases (human) 
NOlHR-32900-09 Pilot study to standardize the 

measurement of 'closing volume' (human) 
NOlHR-32902-07 Pilot study to standardize the 

measurement of closing volume (human) 
NOlHR-62910-02 Fibroprotein networks of pulmonary 

alveolar wall (human) 
NOlHV-22931-14 Therapy for hypertension in general 

population 
NOlHV-22937-07 Therapy for hypertension in general 

population 
NOlHV-22938-11 Therapy for hypertension in general 
population 
AGE (HUMAN), ADULT 
SEE ALSO AGING 
POlHL-11310-12 0057 Mechanisms of cardiovascular 

disease - Blood pressure reduction after heart surgery in 
adults (human) 
** P01HL-U310-12 0082 Mechanisms ol cardiovascular 
disease - Myocardial function in adult congenital heart 
disease (human) 
** POlHL-11310-12 0083 Mechanisms of cardiovascular 

disease - Ventricular volume and hemodynamics in adult 
congenital heart disease 
P60HL-15158-07 0011 Comprehensive sickle cell center ■ 

Clinical services -Adult patients 
P60HL15162-07 0001 Comprehensive sickle cell center - 

Core program-Patient care 
P60HL- 15996-06 0008 Cincinnati comprehensive sickle 

cell center - Patient care (children, adults) 
P60HL-16008-06 0001 Wayne State University 

comprehensive sickle cell center - Patient care system 
(children, adults) 
POlHL-17419-04 0003 Studies on mechanisms of 

hemostasis - Characterization of fibrinogen (human) 
ROlHL-17580-04 The impact of stress on coronary heart 

disease (men) 
ROlHL-18144-03 Preprocessor system for cardiograms 

(human) 
ROlHL-20961-02 Hemoglobin Y chain genes-Evolution and 

inducibility (monkeys, human) 
ROlHL-22123-02 The rale of the red cell in diabetic 

atherosclerosis (human) 
R01HL-22296-01 Autonomic mechanisms in man 
ROlHL-22514-01 Behavior patterns, stress, and 

catecholamines 
N01HV-72917-00 Plasma lipoproteins in identical twins 

(conid) 



•Excludes routine methodology OR covers only general projects which preclude 
"Oriented significantly to above subject. 



indexing at the specific level. 



HI Grant has subprajects descnbing specific research aspects. 
See Appendix for investigator's name and grant number. 



AGE 

AGE (HUAAAN), ADUIT, MIDDLE AGE (45 TO 64 
YRS) 

POlHL-08974-14 0005 Natural and experimental 

atherosclerosis ■ Atherosclerosis, coronary heart disease 

and sudden death (human) 
ROlHL-17818-05 Metabolism of cholesterol and cholesterol 

in man (also rats, monkeys) 
ROlHL-18738-02 Prevention of postoperative venous 

thrombi (human, cattle) 
ROlHL-18776-04 Prevention of acute and fatal 

cardiovascular disease (human) 
ROlHL-19839-09 Factors in youth predisposing to chronic 

diseases (former college students) 

Nmuuloo^^^Sl ^''°'°^^ "' myocardial infaction (human) 
NOlHV-22971-07 Prevention of coronary heart disease 

(human) 
NOlHV-22977-08 Intervention trial for the prevention of 

coronary heart disease (human) 
NOlHV-22979-07 Intervention trial for the prevention of 

coronary heart disease (human) 
N01HV-22980-06 Intervention trial for the prevention of 

coronary heart disease (human) 
NOlHV-22981-10 Intervention trial for the prevention of 

coronary heart disease (human) 
NOlHV-22982-07 Intervention trial for prevention of 

coronary heart disease (human) 
NOlHV-2298307 Intervention trial for the prevention of 

coronary heart disease (human) 
NOlHV-33 105-09 Intervention trial for prevention of 

coronary heart disease (human) 
NOlHV-33106-06 Intervention trial for the prevention of 
coronary heart disease (human) 

AGE (HUMAN), ADULT, OLD AGE (65 TO 99 
YRS) 

POlHL-08805-15 0044 Regulation of ventilation and 

pulmonary circulation - Neurochemical interactions in 
respiratory control (human, dogs, goats) 

AGE (HUMAN), ADULT, YOUNG (21 TO 44 YRS) 

ROlHL-19839-09 Factors in youth predisposing to chronic 
diseases (former college students) 

R01HL19858-03 UMMC -Blood pressure precursors and 
consequences (human) 

ROlHL-19929-03 High blood pressure in the young, 
prevalence and precursors (human) 

ROlHL-19962-03 High blood pressure in young people in 
Tecumseh 

ROlHL-22740-01 Behavior and cardiovascular disease- 
Basic mechanisms (human) 



AGE (HUMAN), CHILDREN 

SEE CHILDREN 

AGE PIGMENT 

SEE LIPOFUSCIN-CEROID 
AGGLUTININS 

SEE IMMUNOLOGY, ANTIBODIES, AGGLUTININS 
AGGLUTININS, PLANT 

SEE PLANTS PROTEINS, LECTINS 
AGGREGATES (CHEMISTRY) 

SEE CHEMICAL AGGREGATES 
AGGREGATION, CELLULAR 

SEE CELL-CELL INTERACTION, CELL AGGREGATION 
AGGRESSION 

SEE PSYCHOLOGY, BEHAVIOR, AGGRESSION 
AGGRESSIVE OUTREACH 

SEE HEALTH CARE SERVICES, CASE FINDING AND OUTREACH 
AGING 

ROlHL-01979-22 Arteriosclerosis in zoo animals on 

controlled diets (animals) 
POlHL-06296-18 0005 Cardiovascular and pulmonary 
adaptation to stress - Regulation of ventricular 
performance (animals) 
ROIHL-06736-18 Biogenic-mechanical factors in 

microcirculation (rats, gerbils) 
POlHL-06835-17 0064 Cardiovascular disease - Studies 

in atherosclerosis (human, animals) 
POlHL-07896-15 0055 Environmental biomedical research 
program - Cerebral blood flow by Xenon-133 inhalation 
(human) 
P01HL-08899-I4 0044 Tolerance to respiratory gases in 

health and disease - Influence of high oxygen pressures on 
cognition and performance 
•* POIHL-08899 14 0046 Tolerance to respiratory gases in 
health and disease - Studies in senile elderly individuals 
^^ ROlHL-10009 13 Regional lung function in man 

ROlHL-10018 11 Effect of aging on beating heart cells in 

culture (rats) 
R01HL-I1551-n RNA and protein synthesis In repair of 

heart injury (mice, rats) 
ROlHL-12711-09 Mathematical approach to cardiovascular 

mechanics (human, animals) 
P01HL-13262-G7 0016 Arterial v»all in atherosclerosis - 
Lipids in elastin preparations from atherosclerotic plaques 
(human, animals) 
ROlHL-13626-06 Lipoprotein lipase and lipoprotein 
removal (human, rats, bacteria) 



•S^^'SXtre'su^^;"'^'^""^'-'™^^^ 



8 

P50HL-14153-07 0010 Johns Hopkins Lung Center- 

Chronic diseases of airways • Risk factors for airviays 
obstruction in a rural community (human) 

ROlHL-14495-05 Solid and structural mechanics of lungs 
(mammals) 

P0IHL-14580-07 0002 Program project in respiratory 

mechanics - Airway aerodynamics (human, dogs) 

ROlHL-1504706 Digital computer analysis of the 
electrocardiogram (human) 

ROlHL-16037-06 Molecular properties of cardiac 
adrenergic receptors 

ROlHL-16330-06 Aging-tissue injury and repair (rats) 

R01HL-16421-08 Determinants of RBC deformability and 
capillary flow (human, mice) 

ROlHL-16768-04 The sympathetic nervous system and the 
arterial wall (rabbits, pigeons) 

ROlHL-16952-05 Cardiovascular pathology (rats, rabbits) 

R01HL-17576-04 Role of sphingomyelin in biomembranes 
and bilayers (rats, other mammals) 

ROlHL-17706-04 Psychosocial hypertension, 
catecholamines and drugs (mice) 

ROlHL-17865-04 Studies on aging-Effects of sex 
hormones (rats, dogs) 

R0IHL18284-04 Aging erythrocytes -Bio-recognition and 
elimination (monkeys) 

ROIHL 1861003 Early intervention of age related arterial 

changes (pigeon) 
ROlHL-18629-04 Influence of aging and hypertension on 

the myocardium (rats) 
POlHL-19242-02 0001 Study of vascular smooth muscle - 

Energy metabolism and protein turnover In vascular smooth 

muscle (rats) 
POlHL-19717-02 0018 Response of the lung to injury - 

Lung mechanics and connective tissue composition in 

human emphysema 
ROlHL-19864-03 0001 Blood pressure of children and 

young adults - Follow up of students from Dormont 

Pennsylvania 
ROlHL-20197-02 Maintenance and repair of vascular 

endothelium (human, animals) 

R01HL-2G373-02 Cardiovascular aging in young men and 
women 

ROlHL-20546-02 Chemical analysis of human arterial 

elastin 
ROlHL-20564-02 Pathogenesis of peripheral arterial 

disease (rats, rabbits) 
ROlHL-20572-02 0003 Hemodynamic relations to 

metabolism in hypertension ■ Cardiac output and organ 

blood flow in hypertension (rats) 
ROlHL-20875-02 Chronic obstructive pulmonary disease- 

Famihal/genetic (human) 
R23HL-21393-01 Cardiac adaptation to aging and stress 

(rats) 
ROlHL-21592-01 Lipoproteins and coagulation factors in 

atherosclerosis (pigeons) 
ROIHL-22040-01 Regulation of lysyl-cross-linking in 

vascular tissue (rats, turkeys) 
ROlHL-2231301 Lung elastic recoil-Age and disease 

(human) 

ROlHL-22671-01 Removal of senescent and stored human 

red cells 
ROlHL-22729-01 Intracellular degradation of newly 

synthesized collagen (human, chick, rabbit) 
ROlHL-22750-01 Digoxin in heart failure with sinus 

rhythm (human) 
ROlHL-22854-01 Noninvasive blood pressure 

measurement (rats) 
ROlHL-22883-01 Lung epithelial cell interactions in vitro 
ROlHL-23994-01 Biochemical properties of human cardiac 

myosin 

AGING, LONGEVITY 

POlHL-06835-17 0024 Cardiovascular disease - Studies 
on the obese spontaneously hypertensive rat 

AGLYCONES OF STEROIDS GLYCOSIDES 

SEE STEROIDS GLYCOSIDES AGLYCONES 
AGONISTIC BEHAVIOR 

SEE PSYCHOLOGY, BEHAVIOR, AGGRESSION 
AGRANULOCYTOSIS 

SEE BLOOD AND RE DISORDERS, LEUKOCYTE DISORDERS 
AGRANULOCYTOSIS 

AGRICULTURAL W/ORKERS 

SEE OCCUPATIONS, AGRICULTURAL WORKERS 
A-H HYPERTENSION 

SEE CARDIOVASCUUR DISO.'<DERS. HYPERfENSION 
(SYSTEMIC), NEUROGENIC HYPERTENSION 
AIDS, HEALTH PERSONNEL 

SEE HEALTH SCIENCES PROFESSIONS, HEALTH (CARE) 
PERSONNEL ALLIED 

AIDS, PSYCHIATRIC 

SEE MENTAL HEALTH PERSONNEL ADJUNCT 
AIR 

SEE ENVIRONMENT, ATMOSPHERE (WEATHER) 
AIR CONDITIONING, HEATING, VENTILATION 

SEE ENVIRONMENT CONTROLLED 



ALB 
AIR EMBOLISM 

SEE CARDIOVASCULAR DISORDERS. EMBOLISM, AIR 

AIR FLOW/METERS RESPIRATORY 

SEE RESPIRATORY DISORDERS DIAGNOSIS. RESPIRATORY 
AIRFLOW MEASUREMENTS* 

AIR MONITORING 

SEE AIR SAMPLING-MONITORING 
AIR POLLUTION 

SEE ALSO HYPERSENSITIVITY. ALLERGENS AIRBORNE 

SEE ALSO PHYSICAL AND/OR CHEMICAL AGENTS 

INTERACTION (BIOLOGICAL AND ECOLOGICAL) 
POLLUTANTS INTERACTION 

SEE ALSO PHYSICAL PROPERTIES. PARTICLES DUST 

SEE ALSO RESPIRATORY DISORDERS. RESPIRATORY SYSTEM 
TOXINS 
P50HL-1413607 0016 Pulmonary SCOR -Airways 

obstructive diseases Environmental factors in airways 

obstructive diseases (human) 
P50HL-14212-07 0015 Correlated studies of pulmonary 

fibrosis - Pulmonary defense mechanisms and fibrotic lung 

disease (rodents, rabbits) 
P50HL15092-07 0010 Immune and fibrotic response to 

occupational environments - Characterization of toluene 

diisocyanate in industrial environments 
R01HL-16C29-05 Bio-organic chemistry of ozone, nitrogen 

dioxide and tobacco smoke 
ROlHL-16674-05 Airborne metals and lung permeability 

(bullfrogs, rats) 
R01HL17921-04 Peroxy radicals to prostaglandins in 

vessels and lung 
ROlHL-18308-03 Comprehensive studies of mucociliary 

transport (dogs) 
ROlHL-19746-03 Proliferation and differentiation of 

alveolar macrophages (mice, hamsters) 
" ROlHL-21008-02 Effect of pollutants on organotypic lung 

cultures (rats) 
•* ROlHL-21009.02 Effects of air pollutants on lung cells In 

culture (rats) 

ROlHL-21352-02 Community studies of obstructive lung 
disease (human) 

AIR POLLUTION CONTROL 

" POlHL-19737.02 0009 Cellular and molecular aspects of 
respiratory physiology - Regulation of tissue oxygen tension 
and body carbon monoxide stores (human, dogs) 

AIR SAMPLING-MONITORING 

" P50HL-15092-07 0001 Immune and fibrotic response to 

occupational environments ■ X-ray diffraction study-Dust 

exposure in asbestos cement products manufacturing 
P50HL-15092-07 0002 Immune and fibrotic response to 

occupational environments - Longitudinal study of 

sandblasters silicosis (human) 
" P50HL- 15092-07 0010 Immune and fibrotic response to 

occupational environments - Characterization of toluene 

diisocyanate in industrial environments 
P50HL-15092-07 0011 Immune and fibrotic response to 

occupational environments - Respiratory and immunologic 

responses in coffee plant workers 
P50HL- 15092-07 0012 Immune and fibrotic response to 

occupational environments - Longitudinal evaluation of 

workers exposed to cotton dust 

AIRBORNE ALLERGENS 

SEE HYPERSENSITIVITY, ALLERGENS AIRBORNE 
AIRCRAFT FLIGHT 

SEE ENVIRONMENT. EXTRATERRESTRIAL. SUPRATERRESTRIAL 
AJMALINE 

SEE ALKALOIDS, RAUWOLFIA TYPE, AJMALINE 
ALANINE 

SEE AMINO ACIDS, ALANINE 

L-ALANINE:2-OXOGLUTARATE 
AMINOTRANSFERASE 

SEE AMINOTRANSFERASES, ALANINE TRANSAMINASE 
ALANINE TRANSAMINASE 

SEE AMINOTRANSFERASES. ALANINE TRANSAMINASE 
ALBUMINOIDS 

M POlHL-13262-07 Arterial wall in atherosclerosis 
ROlHL-17865-04 Studies on aging-Effects of sex 

hormones (rats, dogs) 
ROlHL-17909-04 Drug treatment of vascular scleroprotein 
defects (human, turkeys) 

ALBUMINOIDS, COLLAGEN 

SEE ALSO ALBUMINOIDS, GELATIN 
" ROlHL-01803-23 0016 Arteriosclerosis, glomerulonephritis 

rheumatic fever - Synthesis of basement membrane 

collagen by endothelial cells (human) 
ROlHL-02942-22 Biochemistry of cardiovascular connective 

tissue (human, cattle, primates) 
POlHL-03 174-23 0005 Mechanisms of acute vascular 

reaction to injury - Renal small vessel didease-Cell and 

matrix response (human, mice) 
POlHL-03174-23 0012 Mechanisms of acute vascular 

reaction to injury - Human atherosclerotic plaque in organ 

culture 



at the specific level. 



M Grant has subp; 
See Appendix foi ii.. 



describing specific research aspects. 
■ ' - ti. mp and grant number 



(contd) 



AlB 



• roitll Ob83S W 006? Cstdiovasculjt di««5« Kola ol 

tollfltfii in alhtioscleiosis (dogs, pigfons) 
ROIHIOO'IU IJ lh« niyociidium in diabetes mtllilus 

(dogs monkeys) 
ROIHI 10018 11 tiled ol aging on beating heirt cells in 

cultiiie (lals) . . , 

ROIHI IIIW 1? Vasculai physiology (human, cats dogs) 

• POIHI 11310 1? 0106 Mechanisms ol caidiovnscular 

disease Biochemical chaiacteii/ation ol the collagens in 
vasculai tissue (catte) 
ROIHI 11614 11 Iiace elements in nutrition (chickens. 
lats, human) 

• ROIHI 1?561 11 Cardiovasculat studies on coppei 

deliciency (swine) 

• POIHL 13?62 0; 0012 Afletial wall in atheroscleiosis 

Chaiactetuation ol connective tissue components (animals) 
" POIHI 13262 0? OOlb Arterial wall in alheiosclciosis 
Ciosslinkage biosynthesis in aoitic elastm and collagen 
(animals) 
POIHL 13262 0/ 002!) Arterial wall in atherosclerosis 
Phospholipid and cholesterol esters 
'* ROIHL 14126 U fttect ol (unction on grails and implants 

ol collagen (dogs monkeys) 
•* P50HL 14164 0/ 0036 A/S SCOR Comparative and 
experimental atherosclerosis Connective tissue 
metabolism Interaction with arterial metabolism (monkeys) 
♦* P50HI 14212 0? 0004 Correlated studies ol pulmonary 
fibrosis Collagen metabolism in lung tissue and lung 
cells (human, animal) 
P50HL 1421207 0016 Correlated studies of pulmonary 
fibrosis Role ol pulmonary alveolar macrophages in 
fibrosis (human, rabbit) 
R01H1143440? Platelet function and adenine nucleotide 

metabolism (human) 
ROIHL 1469707 Role of platelet membranes in 

hemostasis (human) 
ROIHL 15013-07 Lung oxidative metabolism and energy 
production (rodents, rabbits) 
** P50HL-1506107 0004 Response of lung to ln|ur> 
Biochemical abnormalities in connective tissues (rats) 
P50HL-1506207 0020 Study of lipoproteins, arteiv wall, 
and atherosclerosis ■ Artery wall reactions Elevated 
pressure and hyperlipemia (monkey) 
P50HL 15103-07 0014 A/S SCOR -Early natural history of 
arteriosclerosis Biochemistry of atherosclerotic lesions 
(monkeys, human, cattle) 
** ROIHL 15335 06 The nature of the collagen-platelet 
interaction (animals) 
ROlHL-15448-06 Surgical and metabolic aspects of 
venous grafts, (dogs, monkeys, rabbits) 
** R01HL15478-05 Lipid flux and collagen synthesis in 

atherosclerosis (rabbits) 
M POlHL-15832-06 Chemical-structural predispositions to 

lung injury 
** P01HL15832-06 0001 Chemical-structural predispositions 
to lung injury - Chemical composition of lung connective 
tissue proteins (human, animals) 
POlHL-15832-06 0002 Chemical structural predispositions 
to lung iniury - Connective tissue in lung in development 
and repair of in)ury (human, rats, mice) 
POIHL 15832-06 0008 Chemical structural predispositions 
to lung injury - Interstitial fibrosis -Connective tissue 
components in normal and diseased lungs 
M POlHL-16118-06 Study of emphysema 
** P01HL16118 06 0003 Study of emphysema - Degradation 

of collagen and elastm (human, hamsters, mice) 
" P01HL16118-06 0004 Study of emphysema Metabolic 
activity of pulmonary connective tissue (human, hamsters) 
POIHL 1611806 0006 Study of emphysema Metabolism 

of elastin (hamsters) 
ROlHL-16206-04 Regression of atherosclerotic plaques 
(monkeys, dogs) 
** ROlHL-16355 05 Reactions of thrombin and collagen with 
platelets (human) 
ROlHL-16437 05 Drug treatment of atherosclerosis 
(rabbits, monkeys) 
** R01HL16588-05 Collagen synthesis in atherosclerosis 
(dogs, rats, rabbits, human) 
ROlHL-16768 04 The sympathetic nervous system and the 
arterial wall (rabbits, pigeons) 
** ROlHL-16904-03 Regulation of smooth muscle cells in 
arteriosclerosis (rabbit aorta) 
ROIHL 17402-04 Mechanism of contact activation of 

intrinsic clotting (human) 
POlHL-17430-05 0007 Control of coagulation - Platelet 
adhesion, aggregation, ultrastructure in flowing blood 
(human, animals) 
** ROlHL-17525-03 Molecular basis of collagen-platelet 
interaction (human, rat) 
ROlHL-17597-05 Role of plasma lipoproteins in 
atherosclerosis (swine, human) 
** ROlHL-17721 04 Effect of sex hormones on vascular 
connective tissue (rats) 
R01HL-I7865-04 Studies on aging-Effects of sex 

hormones (rats, dogs) 
ROIHL 17909-04 Drug treatment of vascular scleroprotein 

defects (human, turkeys) 
P50HL-18318 03 0014 Pathogenesis and complications of 
hypertension - Arterial metabolism and atherogenesis (rat, 
rabbit) 



P50MI 18JI8 0.1 UUl'i Palhogentsii ind complication-, ol 
hypertension Culluied smuuth muscle cells and 
miciovessel met.ibnlism (mammals) 
POIHI 18176 03 0001 Ihiombosis research program 

pioiecl Platelet damage from physical forces and 
artidcial surfaces (human) 
' POIHI 18576 01 0004 thrombosis research program 
project Mechanism and control ol collagen olateltt 
interaction 
■ ROIHL 18593 03 Chaiacterualion ol heart valve collagen 
(human, pig) 
POIHL 18645 03 0001 Biology of the artery wall and 
atherosclerosis Primate arterial smooth muscle and 
atherosclerosis 
POIHL 18645 03 0003 Biology ol the artery wall and 
atherosclerosis Synthesis o' cnnneclive tissue proteins by 
smooth muscle cells (human, monkeys) 
• ROIHI 18650 03 Platelet collagen interaction (human) 
ROIHL 18714 04 Cardiovascular matrix Morphogenesis 

and maturation (human, chick embryo, mammal) 
POIHL 18827 02 0001 Platelet vessel wall inleiactions in 
thiombogenesis Role of endothelial cells in the production 
of thrombi (human, cattle) 
' POIHI 18827 02 0002 Platelet vessel wall interactions in 
thrombogenesis Interactions nl vessel wall 
macromolecules with factor XII (human, rats) 
P50HL18828 03 0002 Specialized center of research in 
thrombosis Endothelial cell biology (humin. guinea pig) 
P50HL 18828-03 0004 Specialized center of research in 
thrombosis Membrane changes in platelet physiology Role 
ol complement (mice, human) 
•• ROlHL-1925202 Vascular connective tissue -Role in 
atherosclerosis (rabbits) 
ROIHL 19425-03 Cardiac function in hypertrophy (dog) 
ROIHL 19537 03 Detection of myocardial injury with 
ultrasound (dogs) 
** ROlHL-19668 03 Biochemistry of lung connective tissue 

(rats) 
POlHL-19717 02 0001 Response of the lung to injury 

Lung elastic tissue (animals) 
•* POIHL 19717 02 0002 Response of the lung to injury 

Prolyl hydroxylase, lysyl hydroxylase and lung collagen 

biosynthesis (rabbits) 
POIHL 19717 02 0004 Response of the lung to injury - 

Regulatory and physical chemical properties of lung lysyl 

oxidase (animals) 
POIHL 1971702 0007 Response of the lung to injury 

Cellular level studies of prostaglandin-like molecules 

(cattle) 
POlHL-19717-02 0008 Response of the lung to injury - 

Experimental models of lung disease 
POlHL-19717-02 0028 Response of the lung to injury - 

Compensatory growth of the lung following pneumonectomy 

(rabbits) 
** ROIHL 19731-03 Collagen in interstitial fibrosis of lung 

(human) 
R01HL-20104 03 Pulmonary granulomatous inflammations 

(mice) 
** R01HL20114 02 Collagen-platelet interaction and human 

aorta collagen (human) 
ROIHL 20426 03 Myocardial function in diabetes mellitus 

(dog, rat) 
R0IHL20447-03 Connective tissue and diabetic vascular 

disease (human) 
ROIHL 20635 03 Factors in lung development (rat and 

chick embryo) 
ROIHL 21095-02 Enzymes of M tuberculosis and 

obstructive lung disease (human, rodents) 
P23HL 21134-02 Immune function and fibrogenesis in 

silicosis (guinea pigs) 
R23HL21225-02 Connective tissue precursor molecules in 
the lung (rabbits, hamsters) 
*• ROIHL 21303 02 Collagen synthesis by cultured human 
vascular cells 
ROIHL 21498-02 Pathophysiology of edema (rats, cats) 
*• R23HL 21504-02 Collagen synthesis in pulmonary fibrosis 
cells (human) 
ROIHL 21617-02 Biochemistry of lung proteoglycans 

(rabbits, cattle) 
R01HL-21G22-02 Structure and interactions of lung 

proteoglycans (cattle) 
ROlHL-21626 01 Proteoglycans of animal lung 

parenchyma (cattle, pigs, rabbits) 
ROlHL-21641 02 Structural studies of lung proteoglycans 

(pigs, cattle, rabbits) 
ROlHL-21644-01 Fibronectin and related glycoproteins 

(human, rodents) 
ROlHL-21646-02 Biosynthesis of fractionated 

proteoglycans of lung (rabbits) 
ROIHL 21649-01 Biochemistry of lung proteoglycans 
(mammals) 
" R23HL-2166301 Regulation of collagen biosynthesis 

(chick, embryo) 
** R01HL21665-01 Collagen polymorphism and arterial 

structure (monkeys, guinea pigs) 
'* ROIHL 21988-01 Biochemistry of human platelet 

chemotaxis 
" R01HL2208120 The mechanism of collagen formation 
(human, cattle) 
ROlHL-22623-01 Polyamines cellular mediators of 
atherogenesis (human) 



AlB 

*• ROIHI ??/?90l Inlficellulii dtgridalion ol newly 
lynlheii/ed follijen (humin. chick iibbill 
ROIHI 22/39 01 Evolution end progiemon ol pediiIrK 

tthaioscleioM'. 
R23H1 ??745 01 Vawulai mech»nif< and itrutluie in 

hypertension (miniatuie swine) 
ROIHI 23547 01 Pulmonary vasculK smooth muwie cell 

dynamics (rat labbil) 
NOIHR 62910 02 Fibroptolein nelworlu ol pulmonery 

alveolar wall (human) 
NO I HV 42969 06 Interactions of nalurel and chemicelly 
modilied biopolymeis with blood (dogil 
•• NOIHV 42984 05 Interactions ol modified biopolymeri with 

blood (humans, rats) 
•• NOIHV 5290/ 04 Interactions ol platelets with collagens 

(human mammals) 
ALBUMINOIDS, COLLAGEN, PROCOLLAGEN 
•• ROIHll/55104 Biosynthesis and metabolism ol 

procollagen (human, monkeys, mice) 
•' POIHI 18827 02 0002 Platelet vessel wall interactions in 
thrombogenesis Interactions ol vessel wall 
macromolecules with factor XII (human, rats) 
POIHL 19717 02 0001 Response of the lung to injury • 

Lung elastic tissue (animals) 
POIHL 19717 02 0002 Response ol the lung to injury ■ 
Prolyl hydroxylase, lysyl hydroxylase and lung collagen 
biosynthesis (rabbits) 
ROIHL 21303 02 Collagen synthesis by cultured human 

vascular cells ^ ^ , 

ROIHL 2166501 Collagen polymorphism and arterial 
structure (monkeys, guinea pigs) 
ALBUMINOIDS, COLLAGEN, TROPOCOILAGEN 
ROIHL 17551-04 Biosynthesis and metabolism of 
procollagen (human, monkeys, mice) 
** R23HL 19594 01 Tropocollagen and tropoelastin uptake in 
lung cells (human) 
POIHL 19717 02 0004 Response of the lung to injuiy - 
Regulatory and physical-chemical properties of lung lysyl 
oxidase (animals) 
ROlHL-21622-02 Structure and interactions ol lung 
proteoglycans (cattle) 

ALBUMINOIDS, ELASTIN 

R01HL-02942 22 Biochemistry of cardiovascular connective 

tissue (human, cattle, primates) 
ROIHL 11614 11 Trace elements in nutrition (chickens, 
rats, human) 
" ROIHL 11963 10 Biochemistry of blood vessel formation 

and disease (swine) 
♦* ROIHL 12561 11 Cardiovascular studies on copper 

deficiency (swine) 
*♦ POlHL-13262-07 0012 Arterial wall in atherosclerosis • 

Characterization of connective tissue components (animals) 
** POlHL-1326207 0015 Arterial wall in atherosclerosis 

Crosslinkage biosynthesis in aortic elastin and collagen 

(animals) 
** POlHL-13262-07 0016 Arterial wall in atherosclerosis - 

Lipids in elastm preparations from atherosclerotic plaques 

(human, animals) 
** POIHL 13262-07 0023 Arterial wall in atherosclerosis - 

Isolation and characterization of soluble elastin 
POlHL-13262-07 0025 Arterial wall in atherosclerosis 

Phospholipid and cholesterol esters 
" P50HL 14218-07 0006 Pulmonary SCOR-Newborn lung 

center Biochemical characteristics of the lung in RDS 

(human, sheep) 
P50HL-15103-07 0014 A/S SCOR -Early natural history of 

arteriosclerosis - Biochemistry of atherosclerotic lesions 

(monkeys, human, cattle) 
M POIHL 15832-06 Chemical-structural predispositions to 

lung injury 
" POIHL 15832-06 0001 Chemical-structural predispositions 
to lung injury - Chemical composition of lung connective 
tissue proteins (human, animals) 
POlHL-15832-06 0002 Chemical-structural predispositions 
to lung injury Connective tissue in lung in development 
and repair of injury (human, rats, mice) 
P01HL15832 06 0008 Chemical-structural predispositions 
to lung injury Interstitial fibrosis -Connective tissue 
components in normal and diseased lungs 
** POlHL-1 5832-06 0009 Chemical-structural predispositions 
to lung mjury Immunology -Enzyme degradation products 
of human lung elastin and microfibril 
** ROIHL 15965-06 Experimental atherosclerosis and elastin 

metabolism (chicks) 
M POIHL 16118-06 Study of emphysema 
" POIHL 16118 06 0003 Study of emphysema - Degradation 

of collagen and elastin (human, hamsters, mice) 
** P01HL-I611806 0006 Study of emphysema - Metabolism 
of elastin (hamsters) 
ROlHL-16206-04 Regression of atherosclerotic plaques 

(monkeys, dogs) 
ROlHL-17597-05 Role of plasma lipoproteins in 
atherosclerosis (swine, human) 
** ROIHL 17721-04 Effect of sex hormones on vascular 
connective tissue (rats) 
ROIHL 1786504 Studies on aging -Effects of sex 

hormones (rats, dogs) 
P50HL-18318 03 0014 Pathogenesis and complications ot 
hypertension Arterial metabolism and atherogenesis (rat, 

rabbit) 

Icontd) 



•Excludes routine methodology OR covers only general projects which preclude indexing at the specific level 
"Oriented significantly to above subject 



M Grant has subprojects describing specific research aspects 
See Appendix for investieator's name and grant number 



ALB 

P50HL18318-03 C015 Pathogenesis and complications of 
hypertension - Cultured smooth muscle cells and 
microvessel metabolism (mammals) 

ROlHL-18441-03 Guidelines for polymers acting as elastin 
substitutes 

R01HL1862503 Organization of arterial ground substance 

(cattle) 
POlHL-18645-03 0003 Biology of the artery wall and 

atherosclerosis ■ Synthesis of connective tissue proteins by 

smooth muscle cells (human, monkeys) 
ROlHL-18918-03 Characterization of lung elastins (rat 

rabbit, chicken. Rhesus) 
ROlHL-18931-02 Lung elastic tissue characteristics 

(swine, human) 

R01HL1925202 Vascular connective tissue-Role in 

atherosclerosis (rabbits) 
" R23HL-I9594-01 Tropocollagen and tropoelastin uptake in 

lung cells (human) 
** POlHL-19717-02 0001 Response of the lung to injury - 

Lung elastic tissue (animals) 
POlHL-19717.02 0002 Response of the lung to iniury ■ 

Prolyl hydroxylase, lysyl hydroxylase and lung collagen 

biosynthesis (rabbits) 
P01HL19717.02 0003 Response of the lung to injury - 
pn,m '',°j7,°,'ni'^'5„"' '" ^'"P'lysema (hamsters, rabbits) 
POIHL.19717.02 0008 Response of the lung to iniurv - 

Experimental models of lung disease 
POllHL.19717-02 0012 Response of the lung to iniury ■ 

Connective tissue biochemistry and enzyme injury of the 

lung (hamsters) 
" POlHL-1971702 0024 Response of the lung to injury - 

Formation of lung alveoli (rats) 
POlHL.19717-02 0028 Response of the lung to iniury - 

Compensatory growth of the lung following pneumonectomy 

(rabbits) 

ROlHL-20447-03 Connective tissue and diabetic vascular 

disease (human) 
ROlHL-20546-02 Chemical analysis of human arterial 

elastin 

" ROlHL-2076402 Elastin and calcification in pulmonary 

and vascular disease ihuman mammals) 
" POlHL-20994-02 0009 Dynamics of neutrophil elastase in 
the lung - Biosynthesis and degradation of elastin in 
emphysema (human, hamsters) 
ROlHL-21095-02 Enzymes of M tuberculosis and 

obstructive lung disease (human, rodents) 
R23HL-2122502 Connective tissue precursor molecules in 

the lung (rabbits, hamsters) 
ROlHL-2161702 Biochemistry of lung proteoglycans 

(rabbits, cattle) 
ROlHL-21622-02 Structure and interactions of lung 

proteoglycans (cattle) 
R01HL-2I64901 Biochemistry of lung proteoglycans 

(mammals) 
ROlHL-2167301 Pathophysiology of venous changes in 

hypertension (rats, rabbits, human, dogs) 
ROlHL-21757-01 Elastin structure'-DNA breathing- 
Hemoglobin S gelation 
ROlHL-21994-01 Structure and development of 
regenerating capillaries (rabbits, chick embryo) 
" ROlHL-22040-01 Regulation of lysyl-cross-linking in 

vascular tissue (rats, turkeys) 
** ROlHL-22208-02 Elastin structure, fibrogenesis and 
disease (chickens, rabbits) 
R23HL-2274501 Vascular mechanics and structure in 

hypertension (miniature swine) 
ROlHL-2320101 Mechanisms of hypertension (human 

rats) 
ROlHL-23542-01 Pulmonary vascular smooth muscle cell 

dynamics (rat. rabbit) 
NOlHR-62910-02 Fibroprotein networks of pulmonary 
alveolar wall (human) 

ALBUMINOIDS, GELATIN 

ROlHL-1801004 Capillary transport of large molecules 
(dogs, sheep) 

ALBUMINOIDS, KERATOHYALIN 

P0IHL06314-17 0048 Immunologic mechanisms in 
cardiovascular disease ■ Pathogenesis of glomerulonephritis 
(rats, mice) 

ALBUMINS 

P01HL06285-18 0203 Cardiovascular-respiratory 

physiology and biochemistry Pathways of hpid transport 

in the blood (animals) 
P01HL-0901M5 0015 A research and resource program 

in blood - Regulation of synthesis and transport of diverse 

proteins in liver (rats) 
ROlHL-12740 10 Hypocholesterolemic agents- 
Stereochemistry (rats) 
ROlHL-13596-07 Clearance of plasma proteins from 

alveoli 
P01HL-I3738-08 0004 Cardiac assist devices and 

artificial hearts - Hematological evaluation of prosthetic 

materials (calves) 
POlHL-13738-08 0005 Cardiac assist devices and 

artificial hearts ■ Development of new materials for 

artificial heart and assist devices (sheep dog) 
POlHL-15596-05 0017 Coagulation, fibrinolysis, 

hemoslasis and hepatitis • Heparin and anlithrombin III 



10 

PClHL-1674805 0006 Cellular and immunological basis 

of pulmonary diseases - Sarcoidosis-Studies with bronchial 

lavage (human) 
M R01HL16916-04 The role of albumins in lung water 

accumulation 
ROlHL-16916-04 0001 The role of albumins in lung water 

accumulation - Capillary permeability (dogs human) 
** ROIHL.16916.04 0002 The role of albumins mlung water 

accumulation - Lung water balance -Forces, models and 

albumin concentrations (rabbits dogs) 
** ROlHL-16916-04 0011 The role of albumins in lung water 

accumulation - Whole body distribution and exchange of 

albumin (rabbits, human, monkeys) 
R01HL-1778I-03 Hypertension, kidney disease and renal 

lymph (dogs, rats) 
ROIHL-18010-04 Capillary transport of large molecules 

(dogs, sheep) 
ROIHL- 185 19-03 Albumin, endothelium and 

hemocompatibility (human, dog, cattle rabbit) 
POlHL-18646-03 0008 Studies basic'to heart 

transplantation - Immunophysiology and early detection of 

rejection (dogs) 
R01HL18736-03 Protein transport through arterial tissue 

(rabbits) 

R01HL-187G2-03 Post-traumatic pulmonary insufficiency 

(dogs) 
" P50HL-19185-02 0007 Pulmonary SCOR -Neonatal 

respiratory distress syndromes - Sodium bicarbonate and 

albumin in resuscitation of preterm infants (human) 
ROlHL-19419-03 Cellular interactions with foreign 

materials (mammals) 
ROlHL-20251-02 A novel approach to nonthrombogenic 

polymer surfaces (sheep, cattle) 
ROlHL-2145202 Pulmonary capillary filtration in 

myocardial ishemia (dogs) 
POlHL-22163-01 0001 Surface thrombogenesis- 

Mechanisms and prevention - Initial blood protein and 

platelet interactions with biomaterials (baboons) 
ROlHL-22911-01 Mechanism of clearance of lung edema 

fluid (dogs) 
ROlHL-22924-01 The airway mucosal barrier (guinea pigs) 
ROIHL 22946-01 Prostaglandins, platelet aggregation and 

vasoactivity (human, rats, rabbits) 

ALBUMINS, CONALBUMIN 

ROlHL-18619-03 Transferrin iron binding and transport 
properties (chicken, rabbit, human) 

ALBUMINS, SERUM ALBUMIN 

ROlHL-02751-21 Function and metabolism of serum 
albumin (mammals, fish, amphibians) 
" POlHL-06370-17 0004 Cardiopulmonary and renal 

pathology research center - Lymphocytes in graft rejection 
and immune surveillance (human) 
P60HL-15160-07 0008 Center for sickle cell disease - 
Isocyanate derivatives and hemoglobin S association 
(human, rat) 
ROlHL-15698-12 Factors affecting the action of 

anticoagulants (rats, human) 
ROIHL- 164 19-03 Arterial uptake of lipoprotein-Kinetic 

analysis (rabbits) 
P60HL-1 7265-04 0001 Community blood resource center 

support - Demonstration and evaluation 
ROlHL-17623-05 Initial events in thrombus formation on 

surfaces (human, rats) 
POlHL-18576-03 0001 Thrombosis research program 
project - Platelet damage from physical forces and 
artificial surfaces (human) 
ROlHL-18619-03 Transferrin iron binding and transport 

properties (chicken, rabbit, human) 
ROlHL-18731-02 RES stimulating materials in 

experimental shock (dogs) 
ROlHL-18887-03 Hypolipidemic drugs-Effects on FFA- 

albumin association (human, cattle) 
ROlHL-20313-02 Surface-induced thrombosis -Modification 
of albumin variants (human, goat) 

ALBUMINS, SERUM ALBUMIN BOVINE 

P50HL19185-02 0007 Pulmonary SCOR -Neonatal 
respiratory distress syndromes ■ Sodium bicarbonate and 
albumin in resuscitation of preterm infants (human) 
ALCOHOL CONSUMPTION 

SEE ALCOHOLISM - DRINKING, ALCOHOL CONSUMPTION 
ALCOHOL RESEARCH REVIEW COMMIHEE 

ROlHL-2036903 The effect of alcohol on the heart (rats) 
ALCOHOLISM 

SEE ALCOHOLISM - DRINKING, ALCOHOLISM 
ALCOHOLISM - DRINKING, ALCOHOL 
CONSUMPTION 
ROlHL-15308-07 Assays lor peptides of lipoproteins 

(human) 
ROlHL-1877604 Prevention of acute and fatal 

cardiovascular disease (human) 
ROlHL-19839-09 Factors in youth predisposing to chronic 

diseases (former college students) 
ROlHL-19984-02 Blood pressure and immunogenetic 

factors in the young (human) 
ROlHL-20179-02 Epidemiology of sudden cardiac death 
among women 



••nn»nL'°"""f ""^''''"•11 OR "vers only general proiects «hich preclude indexing 
Oriented significantly to above subject >. ""<: ncue.iiig 



ALD 

R01HL-2197I.01 Atherosclerotic disease and risk factors 

in twins (human) 
ROlHL-22607-01 Role of apolipoprotein E in lipoprotein 

metabolism (human) 
N01HV^62955-04 Data collection in clinical pathology and 

morbid anatomy (men) 

ALCOHOLISM - DRINKING, ALCOHOLISM 

POlHL-08214-15 0006 Chemical and biological properties 
of lipids ■ Analysis and properties of lipids 

ROlHL-09562-14 Cardiac protein synthesis, overload 
alcohol and anoxia (guinea pigs) 
** ROlHL-20369-03 The effect of alcohol on the heart (rats) 

ROlHL-23945-06 Pathologic effects on cells of modified 
lipoproteins (rats, human) 

ALCOHOLS 

SEE ALSO BILE ALCOHOLS 
ROlHL-13989-05 Role of water in respiratiory protein 
structure 

ALCOHOLS, BUTANOL 

ROlHL-13567-06 Ion transport across cell membranes 
(human) 

ALCOHOLS, DIOLS 

POlHL-08214-15 0006 Chemical and biological properties 

of lipids ■ Analysis and properties of lipids 
POlHL-08214 15 0025 Chemical and biological properties 

of lipids - Biosynthesis and biological functions of 

plasmalogen (cattle) 
** POIHL 08214 15 0027 Chemical and biological properties 

of lipids - Biological functions diol lipids (swine rats 

plants) 
POlHL-0821415 0040 Chemical and biological properties 

of lipids ■ Nuclear magnetic resonance studies of lipids 

ALCOHOLS, DIOLS, ETHYLENE GLYCOL 

ROlHL-20219-02 Ciyopreservation of the isolated heart 
(rats) 

ALCOHOLS, DIOLS, PROPYLENE GLYCOL 

ROlHL-19722-03 Aerosol growth in the respiratory system 

(models) 

ALCOHOLS, ENOLS 

ROlHL-22612 01 Stabilized prostacyclins to treat vascular 
disease 

ALCOHOLS, ETHANOL 

" POlHL-0889914 0027 Tolerance to respiratory gases in 
health and disease - Effects of high oxygen pressures on 
ethanol metabolism (human) 
POlHL-0889914 0061 Tolerance to respiratory gases in 
health and disease Hepatic oxygenation and secretory 
functions (rats, dogs) 
ROlHL-09562-14 Cardiac protein synthesis, overload, 

alcohol and anoxia (guinea pigs) 
P01HL10539-12 0068 Pathophysiology of circulation ■ 
Acute and chronic cardiomyopathies (mice, dogs, hamsters 
human) 
POlHL-11310 12 0092 Mechanisms of cardiovascular 

disease - Exercise electrophysiology (human) 
P01HL1237310 0005 Cardiopulmonary physiology and 
pathophysiology - Characterization of fetal and neonatal 
myocardium (human, cats) 
R01HL14706-07 Fetal hearts in organ culture (mice) 
POlHL-14985-07 0009 Adaptation to hypoxia ■ Influence 
of chemosensitivity on control of breathing during sleep 
(human, dogs) 
ROIHL 17571-03 Study of membrane permeability by NMR 

relaxation (human) 
R01HL18607 03 Metabolic and drug studies on 

experimental fat embolism (mice) 
ROlHL-20369-03 The effect of alcohol on the heart (rats) 
ALCOHOLS, METHANOL 

ROIHL 19491-03 Mechanism of iron storage and 
mobilization by ferritin (horse) 

ALCOHOLS, PROPANOLS 

SEE ALSO NAPHTHYUMINES, PROPRANOLOL 
P01HL06835-17 0057 Cardiovascular disease - Studies 
on cardiac hypertrophy 

ALDEHYDE LYASES 

SEE ALDOLASES 

ALDEHYDES 

SEE ALSO DICARBOXYLIC ALDEHYDES, MALONALDEHYDE 
ROIHL-1824503 Transition state analog inhibitors of 

thrombin (human, cattle) 
ROlHL-23115-01 Regulation of active sodium transport 

(frogs, rats) 

ALDEHYDES, ACETALDEHYDE 

ROlHL-09562 14 Cardiac protein synthesis, overload, 

alcohol and anoxia (guinea pigs) 
ROlHL-18554-03 Taurine metabolism in mammalian heart 

(rodents, cattle, swine) 
ROlHL-2036903 The effect of alcohol on the heart (rats) 
ALDEHYDES, FORMALDEHYDE 

P50HL14230-07 0097 A/S SCOR-Lipids, atherosclerosis 

and thrombosis ■ Studies of circulating platelet aggregates 

(human) 



at the specific level. 



M Grant has subprojecls describing specific research aspects 
See Appendix for investigator's name and grant number 



(contdl 



AID 

ALDOLASIS 

NOIHI l'9?6 18 ChtmKil aitnts and hiiart (lycotytlc 
•nmnes (shnp) 

ALDOSTERONE 

Sn AORtNAl CORIEX HORMONES, ALDOSIERONt 

ALDOSTERONE INHIBITORS 

SEE ADRENAL CORTEX HORMONIS. AIDOSIERONE 
INHIBITORS 
ALDOSTERONE STIMULATING FACTOR ANT PIT 

SEI PITUIIARY OIENCEPHAION HORMONES. ACTH 
ALDOSTERONE STIMULATING FACTORS 

SEE ADRENAL CORTEX HORMONES. ALDOSTERONE 
STIMULATING FACTORS 

ALDOSTERONISM 

SEE ADRENAL GLANDS DISORDERS. HYPERAIOOSTERONISM 

ALERTNESS-VIGILANCE 

SEE PSYCHIC ACTIVITY LEVEL. ATTENTION 

AUXIN 

SEE IMMUNOLOGY. COMPLEMENT 

ALFALFA 

SEE PLANTS. ANGIOSPERMS. LEGUMES, ALFALFA* 

AUESTERASE 

SEE CARBOXYLIC ESTER HYDROLASES. CARBOXYLESTERASE 

ALIMENTARY TRACT 

SEE GASTROINTESTINAL SYSTEM (GENERAL) 

ALKAU METALS 

SEE METALS. ALKALI METALS 

ALKAUES 

SEE ACIDS BASES. ALKALIES 

ALKALINE EARTH METALS 

SEE METALS, ALKALINE EARTH METALS 
ALKALINE PHOSPHATASE 

SEE PHOSPHOMONOESTERASES, ALKALINE PHOSPHATASE 

ALKALOIDS 

SEE ALSO PLANTS EXTRACTS, MEDICINAL PLANTS 
SEE ALSO PURINES. XANTHINES. CAFFEINE 
SEE ALSO PURINES. XANTHINES, THEOPHYLLINE 
SEE ALSO PYRIDINAMIDES, NICOTINAMIDE 
SEE ALSO PYRIDINE CARBOXYLIC ACIDS, NICOTINIC ACID 
SEE ALSO QUINOLINES 
SEE ALSO QUINUCLIDINES 

SEE ALSO TOXICOLOGY, ANIMAL POISONS, BATRACHOTOXIN 
SEE ALSO TOXICOLOGY, ANIMAL POISONS, TETRODOTOXIN 
SEE ALSO TOXICOLOGY, PROTOZOAL TOXINS, SAXITOXIN 
** ROlHL-07502 13 Phytochemistty of the genus fhalictrum 



(dogs, plants) 
ROlHL-12971-15 
ROlHL-1647105 

Indole alkaloids 
RClHL-20579-02 

alkaloids 
ROlHL-22783-01 



Reactions of alkoloids and their analogs 
Cardioactive alloyohimbines and related 

Synthesis of therapeutically important 



Hemodynamic induction of intimal 
fibromuscular lesion 

ALKALOIDS, ACONINE TYPE 

ROlHL-21670-01 Antiarrhythmic studies on 2substituted 
aminoindenes (dogs) 

ALKALOIDS, BERBINES 

ROlHL-1297115 Reactions of alkoloids and their analogs 

ALKALOIDS, CANNABIS 

P01HL14985-07 0004 Adaptation to hypoxia - Control of 

breathing in respiratory failure (human, dogs) 
POlHL-14985-07 0009 Adaptation to hypoxia - Influence 

of chemosensitivity on control of breathing during sleep 

(human, dogs) 
ALKALOIDS, COLCHICINE 

SEE ALSO ALKALOIDS, OEMECOLCINE 
POlHL-06370-17 0004 Cardiopulmonary and renal 

pathology research center - Lymphocytes in graft rejection 

and immune surveillance (human) 
R01HL13909-27 Physiochemistry and Immunol )gy of 

macromolecules 
ROlHL-16437-05 Drug treatment of atherosclerosis 

(rabbits, monkeys) 
ROlHL-20643-02 Analysis of heart cell contraction (rats) 

ALKALOIDS, DEMECOLCINE 

R01HL15512-06 Drug treatment of stenosing primate 
atherosclerosis (rabbits, monkeys) 

ALKALOIDS, ERGOT 

ROlHL-18590-03 Cerebral blood flow after cardiac arrest 

(dogs, monkeys) 
ROlHL-20579-02 Synthesis of therapeutically important 

alkaloids 
ALKALOIDS, ERGOT, METHYSERGIDE 

ROlHL-22005-01 Intermittent retropcrfusion of ischemic 

myocardium (dogs) 



1 1 

ALKALOIDS, MONOCROTALINE 

POIMI 0H80i I'j 0048 Regulation ol vcniilatlon ind 

puliiionjiy ciiculntion Pefm«»billly ol ilveolo Ctpllliry 
m«mbnn« in normal pulmonary hyperteujivf lung 

ROIHL 19394 03 Biochnmislry and lejulalion ol taurine in 
the heart (lats. guincn pigj. cats) 

ALKALOIDS, MORPHINES 

POIHI 08899 14 0030 Tolerance to respiratory gaies In 

health and disease Dynamic characleiisticj ol respiratory 
control components (human, cats) 
POIHI 12/38 10 0042 Physiologic pharmacology and its 

clinical applications Centrogenic cardiac arrhythmias 
(cats) 
ROIHL 14092 07 Homeostatic regulation ol plasma choline 

(rats. dogs, chickens) 
POIHL 1498507 0003 Adaptation to hypoxia Hypoxia 

and oxygen transport (human, dogs) 
POIHL 1498507 0009 Adaptation to hypoxia Influence 
of chemosensitivity on control of breathing during sleep 
(human, dogs) 
ROIHL 1602205 Determinants of the ventilatory response 

to hypoxia (goats, cats) 
P50HL1766504 0026 Study of ischemic heart disease 

Anesthesia Myocardial ischemia and hemodynamics in 
coronary disease (human) 
*• ROIHL 17954-03 Narcotics and the circulation (human, 
dogs, pigs, monkeys) 
ROlHL-2037102 Intravascular redistribution of blood 
volume (dogs) 
ALKALOIDS, MORPHINES, NALOXONE 

R01HL1795403 Narcotics and the circulation (human, 
dogs, pigs, monkeys) 
ALKALOIDS, RAUWOIFIA TYPE, AJMALINE 

ROlHL-21672-01 Antiarrhythmic drug action on VMAZ of 
cardiac cells 
ALKALOIDS, RAUWOIFIA TYPE, RAUWOLFIA 
SEE ALSO ALKALOIDS, RAUWOLFIA TYPE, AJMALINE 
SEE ALSO ALKALOIDS, RAUWOLFIA TYPE, RESERPINE 
SEE ALSO ALKALOIDS. RAUWOLFIA TYPE, YOHIMBINE 
R01HL107 11-12 Cooperative study of treatment of 
hypertension (human) 
ALKALOIDS, RAUWOLFIA TYPE, RESERPINE 
R01HL1O71112 Cooperative study of treatment of 

hypertension (human) 
ROlHL-147 13-06 Hypothermia and the heart (bats, guinea 

pigs) 
ROIHL-15047-06 Digital computer analysis of the 

electrocardiogram (human) 
ROlHL-16471-05 Cardioactive alloyohimbines and related 

indole alkaloids 
ROlHL-17909-04 Drug treatment of vascular scleroprotein 

defects (human, turkeys) 
P01HL18974-03 0011 Experimental neurogenic 
hypertension program - Biochemistry and regulation of 
brain tryptophane hydroxylase (rats) 
R23HL-19573-01 Studies on pulmonary serotonin (mice) 
ROIHL 20579-02 Synthesis of therapeutically important 

alkaloids 
ROlHL-22563-02 Prostaglandins, the kidney and 

hypertension (rats) 
ROlHL-22573-01 Treatment of post surgical 
vasoconstriction (dogs, monkeys, human, rats) 
** NOlHV-62900-00 Study of breast cancer and reserpine use 

(human) 
ALKALOIDS, RAUWOLFIA TYPE, YOHIMBINE 
ROlHL-08359-14 Morphopharmacology of vascular 
adrenergic transmission (rabbits, rats) 
*• ROlHL-16471-05 Cardioactive alloyohimbines and related 
indole alkaloids 

ALKALOIDS, RYANIA 

R23HL-21325-02 Sarcomere kinematics in cardiac 
contraction (rats, rabbits) 

ALKALOIDS, SENECIO 

ROlHL-19394-03 Biochemistry and regulation of taurine in 
the heart (rats, guinea pigs, cats) 

ALKALOIDS, VINBLASTINE 

ROlHL-20643-02 Analysis of heart cell contraction (rats) 

ALKALOIDS, VINCA 

SEE ALSO ALKALOIDS, VINBLASTINE 
ROlHL-16437-05 Drug treatment of atherosclerosis 
(rabbits, monkeys) 

ALKALOSIS 

SEE BODY FLUID BALANCE, ACID-BASE, ALKALOSIS 

ALKANES 

POlHL-12157-11 0038 Functions and mechanisms of cell 

membrane ion transport - Mechanisms and interactions of 
gases and ions with bilayer membranes (human) 

ALKANES, METHANE 

ROlHL-17702-04 Electro-optical dyes as probes of heart 

excitability 
ROlHL-1974603 Proliferation and differentiation of 

alveolar macrophages (mice, hamsters) 



ALL 



ALKENES, ISOPRENOIDS 

Sff AISOPIASIIC, HDBHIR 
Sff ALSO IfHPTNf".. CAKOIINOID', 
Sff Also VITAMIN A 
Sff Also VITAMIN K 
ROIHI 16101 0') Piolein lipid inleuchon (batlMli, 

modeli) 
ROIHL 19011 03 Smooth muscle cell membrane 
glycoprotein biosynthesis (caltle) 

AlKYL (GROUPS) 

POIHI 0*214 15 0025 Chemical and biological properliei 

of lipids Biosynthesis and biological functions ol 
plasmalogen (cattle) 
POIHI 08214 15 00?/ Chemical and biological properties 

of lipids Biological functions diol lipids (swine, rats, 
plants) 
POIHL 15195 04 0001 Program project in biological 

materials Design and synthesis 
AlKYL (GROUPS), ALKYLATION-DEALKYLATION 
POIHL 185/7 03 0004 Lipoproteins Cell surtace 

interactions Analysis and chemical modification of 
proteins in lipid transport (human, dogs) 
ROIHL 19654 03 Biochemical pharmacological evaluation 

of lung cells (rabbits) 
ROIHL 22471 01 Biochemistry of prothrombin quick 

(human) 
ROIHL 22845 01 Response of cardiac myosin to 
hypertrophic stress (rabbits) 
AlKYL (GROUPS), DEMETHYLATION 

ROlHL-19654 03 Biochemical pharmacological evaluation 
of lung cells (rabbits) 
AlKYl (GROUPS), METHYLATION 

POIHL 11351 12 0004 Cellular and molecular 

mechanisms of myocardial function Molecular 
mechanisms of contractile function and differentiation 
(animals) 
R01HL12647-08 Inactivation of norepinephrine in vascular 

tissue 
POlHL-13851 16 Cyclotron produced isotopes in biology 

and medicine (human, animals) 
P01HL18577-03 0004 Lipoproteins-Cell surface 

interactions • Analysis and chemical modification of 
proteins in lipid transport (human, dogs) 

ALKYLATING AGENTS 

SEE ALSO HALOALKYLAMINES, NITROGEN MUSTARDS 
POlHL-2101602 0002 Sickle cell anemia and other 

hemoglobinopathies - Molecular events proceeding gelation 

of Hb S 
POlHL-21016-02 0004 

hemoglobinopathies 
** POlHL-21016-02 0010 

hemoglobinopathies 

agents 
** POlHL-21016-02 0011 

hemoglobinopathies 

agents (hamsters) 
POlHL-21016-02 0013 

hemoglobinopathies 

cell treated with anti-sickling agents (rats) 

ALKYLATION 

SEE ALKYL (GROUPS), ALKYLATION-DEALKYLATION 

ALKYL NITRILES 

SEE CYANIDES, ALKYL NITRILES 

ALKYNES 

ROlHL-20996-02 Structural and reactivity of iron and 
cobalt complexes 

ALLELES 

SEE GENETICS, GENES. ALLELES 

ALLERGENS 

SEE HYPERSENSITIVITY, ALLERGENS 

ALLERGENS AIRBORNE 

SEE HYPERSENSITIVITY, ALLERGENS AIRBORNE 

ALLERGIC ALVEOLITIS 

SEE RESPIRATORY DISORDERS, PNEUMONITIS ALLERGIC 
INTERSTITIAL 

AUERGIC INTERSTITIAL PNEUMONITIS 

SEE RESPIRATORY DISORDERS. PNEUMONITIS ALLERGIC 
INTERSTITIAL 

ALLERGY 

SEE HYPERSENSITIVITY (GENERAL) 
ALLERGY AND IMMUNOLOGY STUDY SECTION 

** ROlHL-03919 20 The cell suface of streptococci (rats. 

human) 
** ROlHL-08399-15 Platelet injury in infections and allergic 

diseases (human) 
** ROlHL-10608 12 Digoxin-specific antibodies (human) 
** ROlHL-18526-03 Kinins and the human lung 
** ROlHL-20125-02 Cyclic nucleotides and alveolar 

macrophage activation (rabbits) 
** ROlHL-20394-03 Complement activation by heart 

subcellular membranes (human, dog) 

(contdl 



Sickle cell anemia and other 
Kinetics of sickling 

Sickle cell anemia and other 
• Alkylureas as potential anti-sickling 

Sickle cell anemia and other 
- Metabolic effects of anti-sickling 

Sickle cell anemia and other 
■ Microcirculatory response to sickle 



•Excludes routine raethodotogy OR covers only general projects which preclude 
"Oriented significantly to above subject 



indexing at the specific level. 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



ALL 

** ROlHL-2053309 Pathogenesis of rheumatic fever (human 

rabbits) 
*• ROlHL-21874.01 SRS-A-lts biosynthesis and action 

ROlHL-23586-06 Pharmacologic control of hypersensitivitv 
phenomena (human) 

ALLIED HEALTH PERSONNEL 

SEE HEALTH SCIENCES PROFESSIONS, HEALTH (CARE) 
PERSONNEL ALLIED 

ALLIED HEALTH PERSONNEL EDUCATION 

SEE EDUCATION, HEALTH OCCUPATIONS, ALLIED 
ALLIUM 

SEE PLANTS, ANGIOSPERMS, ALLIUM* 
ALLOANTIBODIES 

SEE TISSUE COMPATIBILITYTRANSPUNT, ISOALLOANTIBOOIES 
ALLOANTIGENS 

SEE TISSUE COMPATIBILITY-TRANSPUNT, ISOALLOANTIGENS 
ALLOANTISERA 

SEE IMMUNITY IMMUNOSUPPRESSION, ALLOANTISERA 

ALLOGENIC INHIBITION, ANTISERA 

SEE IMMUNITY, IMMUNOSUPPRESSION, ALLOANTISERA 

ALLOGRAFT 

SEE TISSUE COMPATIBILITY TRANSPLANT, TRANSPLANTATION 
HOMOLOGOUS 

ALLOIMMUNITY 

SEE TISSUE COMPATIBILITY TRANSPLANT, ISOALLOIMMUNITY 
ALLOPURINOL 

SEE DIAZ0L0DIA2INES, PYRAZOLOPYRIMIDINES, ALLOPURINOL 
ALLOSTERIC SITES 

SEE CHEMICAL REACTION SITES, ALLOSTERIC SITES 
ALLOXAN 

SEE PYRIMIDINES, ALLOXAN 
ALLOYS 

SEE METALS, ALLOYS 
ALLYLAMINES 

SEE AMINES, ALLYLAMINES 
ALOUATTA 

SEE MAMMALS, PRIMATES, MONKEYS AND APES 

(ANTHROPOIDS, NON-HUMAN), NEW WORLD MONKEYS 
(PLATYRHINES)* 

ALPHA GLOBUIIN(S) 

SEE GLOBULINS, ALPHA GLOBULINS 
ALPHA 2-AP-GLOBULIN 

SEE IMMUNOLOGY, ACUTE PHASE PROTEINS 

ALPHA RECEPTORS 

SEE NEUROTRANSMITTERS RECEPTORS, ADRENERGIC 
RECEPTORS, ALPHA RECEPTORS 

ALPHA WAVE (BIOFEEDBACK) CONDITIONING 

SEE PSYCHOLOGY, CONDITIONING, AUTOGENIC AND INTERNAL 
CONTROL 

ALPHA WAVE (TROPHOTROPIC) STATE 

SEE PSYCHIC ACTIVITY LEVEL, TROPHOTROPIC STATE 
ALPRENOLOL 

SEE AMINO ALCOHOLS, PROPANOLS, ALPRENOLOL 
ALTERNATION OF GENERATIONS 

SEE BIOLOGY, LIFE CYCLE 
ALTITUDE 

SEE ENVIRONMENT, ALTITUDE 
ALTITUDE STRESS 

SEE ENVIRONMENT, STRESS, ALTITUDE 
ALVEOLAR MACROPHAGES 

SEE RESPIRATORY SYSTEM, ALVEOUR MACROPHAGES 
ALVEOLITIS ALLERGIC 

SEE RESPIRATORY DISORDERS, PNEUMONITIS ALLERGIC 
INTERSTITIAL 

ALVEOLUS, LUNG 

SEE RESPIRATORY SYSTEM, LUNG ALVEOLUS 
AMERICAN INDIANS 

SEE SOCIAL GROUPS, ETHNIC, AMERICAN INDIANS 
AMERICAN TYPE CULTURE COLLECTION 

SEE TISSUE (CELL) CULTURE, CELL CULTURE COLLECTIONS 
BANKS AND REGISTRIES 

AMIDATION 

SEE AMIDES, AMIDATION 
AMIDES 

SEE ALSO PHOSPHORAMIDES 
SEE ALSO SULFONAMIDES 
ROlHL-22780-01 Factors modifying the reaction properties 
of HgS (human) 



12 

AMIDES, ACETAMIDES 

POlHL-1559605 0008 Coagulation, fibrinolysis, 

hemostasis and hepatitis - Structural studies and 
fractionation of antihemophilic factor (human) 

R01HL17571-03 Study 
relaxation (human) 

POlHL.20993-02 0004 Population dynamics of arterial 

cells in atherogenesis ■ Modifications of cholesterol balance 
related to arterial cell divisions (swine) 

AMIDES, AMIDATION 

R01HL14820-07 Factors affecting physiology of biological 

Pfini!r,''no«fn*,''nZ"* "' membrane permeability by NMR 
P60HL-20985.01 0006 Northern California sickle cell 

center ■ Antisickling properties of imidoeslers (human, rats) 
R01HL-2164401 Fibronecfin and related glycoproteins 

(human, rodents) 

AMIDES, UREA 

SEE ALSO THIOUREA 
ROlHL-02334-23 Micropuncture study of kidney function 

(rats, animals) 
P01HL-) 13 10-12 0080 Mechanisms of cardiovascular 

disease - Metabolism of 'he hyperlrophied myocardium 

(human) 
P01HL1441407 0014 Environmental influences on 

cardiorespiratory and cellular functions Temperature and 

acid-base status in tissues, cells, and subcellular system 
POIHL-15596-05 0008 Coagulation, fibrinolysis, 

hemostasis and hepatitis - Structural studies and 

fractionation of antihemophilic factor (human) 
R0iHL1637504 Investigation of hemoglobin S properties 

(human) 
ROlHL-17571-03 Study of membrane permeability by NMR 

relaxation (human) 
ROlHL-17847-04 Cardiovascular and renal functions of 

marmots 
P50HL.191 53-02 0005 SCOR-Pulmonary edemas-Eitology 

pathogenesis - Lung vascular permeability measured by 

indicator dilution methods (sheep) 
POlHL-21016-02 0002 Sickle cell anemia and other 

hemoglobinopathies - Molecular events proceeding gelation 

of Hb S 

P01HL21016-02 0004 Sickle cell anemia and other 

hemoglobinopathies ■ Kinetics of sickling 
■?* POlHL-2101602 0010 Sickle cell anemia and other 

hemoglobinopathies ■ Alkylureas as potential anti-sickling 

agents 
POlHL-210 16-02 0013 Sickle cell anemia and other 

hemoglobinopathies - Microcirculatory response to sickle 

cell treated with anti-sickling agents (rats) 
ROlHL-22924-01 The airway mucosal barrier (guinea pigs) 



AMIDINOTRANSFERASES 



•SSfl™"*'"! '"'^.!'°''°"'» 0" '='"«'S only general projects which preclude indexing 
Uriented significantly to above subject. 



ROlHL-201 06-02 Coupling of platelet contractile proteins 
to fibrin (human) 

AMILORIDE 

SEE PYRAZINAMIDES, AMILORIDE 
AMINE HORMONES 

SEE CHOLINE, ACETYLCHOLINE 

SEE PHENYLALKYUMINES, CATECHOLAMINES, EPINEPHRINE 

SEE PHENYULKYLAMINES, CATECHOLAMINES 

NOREPINEPHRINE 
SEE THYROID HORMONES, THYROXINE 
SEE THYRONINE, TRIIODOTHYRONINE 
AMINE OXIDASE 

SEE OXIDOREDUCTASES, AMINE OXIDASE (FUVIN 
CONTAINING) 

AMINE OXIDASE (FLAVIN CONTAINING) 

SEE OXIDOREDUCTASES, AMINE OXIDASE (FLAVIN 
CONTAINING) 

AMINE OXIDASE (PYRIDOXAL CONTAINING) 

SEE OXIDOREDUCTASES, AMINE OXIDASE (PYRIDOXAL- 
CONTAINING) 

AMINE OXIDASE INHIBITORS 

SEE ENZYME INHIBITORS, MONOAMINE OXIDASE INHIBITORS 
AMINES 

SEE ALSO AMMONIUM QUATERNARY 
POlHL-15832-06 0007 Chemical-structural predispositions 

to lung injury - Inactivation of vasoactive agents by the 

lung (human, rats, cats, dogs) 
ROlHL-20622-02 Pulmonary uptake and accumulation of 

drugs (rabbits, rats) 

AMINES, ALLYLAMINES 

R23HL-21327-02 Molecular mechanisms of chemical 
myocardiopathies (rats) 

AMINES, BIOGENIC, NEURAL 

SEE NEUROTRANSMinERS (GENERAL) 

AMINES, DIAMINES 

R0IHL-20079-02 0001 Thromboresistant material - Active 

and passive thromboresistant surfaces 

AMINES, HYDROXYLAMINES, HYDROXAMIC 
ACIDS 

R01HL-18679-04 Synthetic protease inhibitors 

at the specific level. 



AMI 

R01HL-200 16-03 Chelator development for thalassemia 
(human, mice, rats, dogs, monkeys) 

AMINES, POLYAMINES 

R01HL-167i4-05 Endothelial cell communication in 

homeostasis (human, mammals) 
" P50HL-19157-02 0009 Studies in cystic fibrosis and 

bronchiolitis - Polyamine metabolism in cystic fibrosis 

(human, rat) 
P01HL-20984-02 0006 Cellular mechanisms in cardiac 

hypertrophy • Early biochemical aspects of cardiac 

hypertrophy (rats) 
ROlHL-2262301 Polyamines cellular mediators of 

atherogenesis (human) 
ROlHL-22883-01 Lung epithelial cell interactions in vitro 
AMINES, PUTRESCINE 

POIHL 13851-16 Cyclotron produced isotopes in biology 

and medicine (human, animals) 
P50HL-19157-02 0009 Studies in cystic fibrosis and 

bronchiolitis Polyamine metabolism in cystic fibrosis 

(human, rat) 

AMINES, SPERMIDINE 

P50HL-19157-02 0009 Studies in cystic fibrosis and 
bronchiolitis - Polyamine metabolism m cystic fibrosis 
(human, rat) 

AMINES, SPERMINE 

P50HL-19157-02 0009 Studies in cystic fibrosis and 

bronchiolitis - Polyamine metabolism in cystic fibrosis 
(human, rat) 

AMINO ACID ANALYZER 

SEE PHYSICAL SEPARATION. CHROMATOGRAPHY, AMINO ACID 
ANALYZER* 

AMINO ACID DECARBOXYLASES 

SEE DECARBOXYLASES, AMINO ACID DECARBOXYLASES 
AMINOACIOOPATHIES, ACQUIRED 

P01HL18645-03 0006 Biology of the artery wall and 
atherosclerosis - The platelet and atherosclerosis (monkeys 
baboons) ' 

AMINOACIOOPATHIES, INBORN 

SEE METABOLIC DISORDERS INBORN, AMINOACIOOPATHIES 
AMINO ACID OXIDASES 

SEE OXIDOREDUCTASES. AMINO ACID OXIDASES 
AMINO ACIDS 

SEE ALSO AMINO ACYL TRNA 

SEE ALSO AMINOSULFONIC ACIDS 

SEE ALSO CARBAMATES 

SEE ALSO CYCLIC AMINO ACIDS 

SEE ALSO NUTRITION. DIETARY CONSTITUENTS DIETARY 
AMINO ACIDS 

SEE ALSO OXAMATES 
R01HL-01974-24 Ion-pump in the erythrocyte (rabbits 

guinea pigs) 
P01HL-07896-15 0032 Environmental biomedical research 
program ■ Fluorometry study of brain exposed to hyperbaric 

oxygen (dogs, cats) 
ROlHL-13193-09 Pathophysiology of post-traumatic and 

shock states (rodents, dogs) 
POlHL-15195-04 0004 Program project in biological 

materials ■ Biological evaluation and surface interaction 

studies (dogs) 
POlHL-15832-06 0001 Chemical structural predispositions 

to lung injury - Chemical composition of lung connective 

tissue proteins (human, animals) 
R0IHL-16553-05 Diagnosis of myocardial infarction by 

radioisotopes (mice, rats, goats) 
ROIHL- 17930-03 Platelet membrane function-Assessment 

and application (animals) 
ROlHL-18593-03 Characterization of heart valve collagen 

(human, pig) 

R01HL-20344-02 Regulation of protein turnover in lung 

tissue (rats) 
ROlHL-21140-01 Studies of pulmonay alveolar 

macrophage function (rabbits) 
ROlHL-21970-01 Myofibrillar assembly and breakdown in 

cardiac muscle (rats) 
R01HL-22387-01 Metalloenzymes and disease 
ROlHL-22780-01 Factors modifying the reaction properties 

of HgS (human) 

AMINO ACIDS, ALANINE 

POlHL-15195-04 0001 Program project in biological 

materials - Design and synthesis 
P50HL-17651-04 0041 Ischemic heart disease specialized 

center of research - Biochemical indices of ischemic injury 

(guinea pig) 
ROlHL-21381-02 Amino acid metabolism in normal and 

hypoxic myocardium (rabbits) 

AMINO ACIDS, GAMMA-AMINOBUTYRIC ACID 

ROlHL-05883-18 0001 Reflex control of resistance and 

capacitance vessels - Naturally occurring vasoactive 
substances and the vascular neuroeffectors (dog) 

R01HL-I3187-09 Central neural control of cardiovascular 
function (cats) 

POlHL-16878-05 0004 Control of ventilation in health 
and disease - Neurotransmitters in the respiratory system 
(cats) 



M Grant has subproierts describing specific research aspects 
See Appendix for investigator's name and grant number. 



(contdl 



AMI 

KOIHl 1/90/04 Bidin lenuldlioii ot ciididc jiihylhnua 

(pi|S. Cils, rjts) 
ROIHI ??7I50I N«ut«l inlegiation ol lh» ctcdiowasculat 
it'llews (dogs)) 
AMINO ACIDS, AlPHA-AMINOISOBUTYRIC ACID 
St[ ALSO CYCIIC AMINO ACIDS, OOPA AlPHA Ml IHYl DOI'A 
ROIHI ?23M 01 Alpha adreneigic elleils on heart 
metabolism (lats) 

AMINO ACIDS, BRANCHED CHAIN AMINO 
ACIDS 

PbOHl l/bBI) 04 00:9 Study of ischemic heart disease 

Myocardial ptolein synthesis and degradation in low oiygen 

stales (Mhbit, dog) 
ROIHL 18;'S8 04 Regulation ol protein degradation in 

heart (rats) 
ROIHL 20388 03 Regulation ot protein turnover in diabetic 

heart (rat) 
ROIHL 21381 02 Ammo acid metabolism in normal and 

hypoxic myocardium (rabbits) 
AMINO ACIDS, N-CARBAMYl AMINO ACIDS 
P60HL 151600? 0008 Center (or sickle cell disease 

Isocyanate derivatives and hemoglobin S association 

(human, rat) 

AMINO ACIDS, CREATINE 

ROIHI 2320501 Contraction ot pulmonary vascular 
smooth muscle (cat) 

AMINO ACIDS, CREATINE PHOSPHATE 

*• P01HL06312 17 0034 Surgical cardiology Metabolic 

factors in cardiac function-Creatine phosphate depletion 

(animals) 
POIHL 1135112 0021 Cellular and molecular 

mechanisms of myocardial function • Muscle energetics 

(frogs) 
P01HL1135M2 0022 Cellular and molecular 

mechanisms of myocardial function • Energetic sequelae of 

shortening -Myothermal and biochemical (frogs) 
POIHL 11351 12 0023 Cellular and molecular 

mechanisms of myocardial function - Energetics ol 

mammalian muscle (rats) 
POIHL 1583506 0011 Study of muscles related to heart 

disease - Energetics and mechanism of muscle contraction 

(frogs, rabbits) 
P50HL 1767004 0023 Study of ischemic heart disease - 

Energy metabolism in acute myocardial ischemic injury 

(dogs) 
ROIHL 20658-01 Myocardial energy transport Creative 

kinase (human, cattle, dog) 
ROlHL-21312-01 Sarcomere mechanics in disrupted 

ventricular muscle (guinea pigs) 
R23HL-21842 01 Control of sugar entry in normal and 

diabetic heart (rats) 
ROlHL-22290-01 Cardiac energy metabolism and protein 

synthesis (mice) 

AMINO ACIDS, CREATININE 

R01HL40612-13 0018 Humoral factors in heart failure 
and hypertension ■ The pathogenesis of experimental renal 
hypertension (dogs, rabbits, rats) 

AMINO ACIDS, DIETARY 

SEE NUTRITION, DIETARY CONSTITUENTS, DIETARY AMINO 
ACIDS 
AMINO ACIDS, ETHYLENEDIAMINO ACIDS, EDTA 

P50HL-I4230-07 0097 A/S SCOR- Lipids, atherosclerosis 

and thrombosis ■ Studies of circulating platelet aggregates 

(human) 
R01HL16010-16 

(frogs) 
ROlHL-16674-05 

(bullfrogs, rats) 

AMINO ACIDS, GLYCINE 

SEE ALSO AMINO ACIDS, SARCOSINE 
SEE ALSO PEPTIDES, GLUTATHIONE 
ROlHL-02558-22 Structure-function relationships in the 

heme proteins (human, cattle) 
ROlHL-13187-09 Central neural control of cardiovascular 
function (cats) 
** ROIHL-13256-08 Ammo acid transport by red cell 
membranes (pigeons) 
POlHL-16878-05 0004 Control of ventilation in health 
and disease - Neurotransmitters in the respiratory system 
(cats) 
ROlHL-21303-02 Collagen synthesis by cultured human 
vascular cells 

AMINO ACIDS, HIPPURATES, P- 
AMINOHIPPURATE 

ROlHL-02835-21 Renal transport carrier for organic 
compounds (dogs, rats) 

AMINO ACIDS, HOMOSERINE 

R01HL-18818-04 Stereochemical mechanism of sickling of 
hemoglobin S (human) 

AMINO ACIDS, LEUCINE 

POlHL-15195-04 0001 Program project in biological 
materials - Design and synthesis 



Cellular basis of cardiac contractility 
Airborne metals and lung permeability 



13 

POIHl 19742 02 0001 Study ot vascular \moolh muicle 

(nergy metiibolism and protein turnover in va\culai \moolh 
muscle (rals) 

AMINO ACIDS, IIPOAMINO ACIDS 

Ml CMOSI'IIOIIPIDS PHOSI'IKICIYCIHIIUS, PHOSPHATIOYl 
SiKINt 
AMINO ACIDS, PHOSPHOSERINE 

POIHL 1215/ II 003H (unilions and mechanisms of cell 

membrane ion transport Mechanisms and inleraclions ol 
gases and ions with bilayer membranes (human) 

AMINO ACIDS, SARCOSINE 

•• POIHI 06835 I / 0056 Cardiovascular disease 

Angiotensin analogs Sarcosine on arterial pressure, 
aldosterone (dogs) 

AMINO ACIDS, SERINE 

SEE ALSO AMINO ACIDS. PHOSPHOSERINE 

SEE ALSO PHOSPHOLIPIDS. PHOSPHOGLYCERIDES. 

PHOSPHATIOYl SERINE 
ROIHL 15958 06 X ray diffraction analysis ol thrombin 
and neurotoxin 

AMINO ACIDS, SERUM AMINO ACIDS 

R01HL1632005 Vasoactive peptides which stimulate 
smooth muscles (rats, human) 

AMINO ACIDS, UREA CYCLE 

SEE ALSO AMIDES, UREA 
SEE ALSO DIAMINO ACIDS, ARGININE 
ROlHL-20070-02 Alpha 1 antitrypsin deficiency (human, 
hamsters) 

AMINO ACIDS, VALINE 

POlHL-15195-04 0001 Program proiect in biological 

materials Design and synthesis 
ROIHL 18819 07 Chemical studies on sickle cell 
hemoglobin (human) 
AMINO ACIDS METABOLISM (GENERAL) 
SEE ALSO AMINO ACIDS TRANSPORT (GENERAL) 
SEE ALSO METABOLIC DISORDERS INBORN, 

AMINOACIDOPATHIES 
SEE ALSO PROTEINS METABOLISM 
ROIHL 09172-15 Protein and RNA synthesis in heart 

muscle (rats) 
POlHL-1 1310-12 0080 Mechanisms of cardiovascular 
disease - Metabolism of the hypertrophied myocardium 
(human) 
ROIHL 12564-09 Control of respiration and blood gases 
(human, dog) 
** ROlHL-13193-09 Pathophysiology of post-traumatic and 
shock states (rodents, dogs) 
ROlHL-14706-07 Fetal hearts m organ culture (mice) 
P50HL-1 7665-04 0029 Study of ischemic heart disease • 
Myocardial protein synthesis and degradation in low oxygen 
states (rabbit, dog) 
ROlHL-18258-04 Regulation of protein degradation in 

heart (rats) 
POlHL-1857503 0005 Mechanisms of vascular changes 
m hypertension Renin synthesis in normotensive and 
hypertensive pigs (also rats, dogs) 
POIHL 19242 02 0001 Study of vascular smooth muscle - 
Energy metabolism and protein turnover in vascular smooth 
muscle (rats) 
ROlHL-20388-03 Regulation of protein turnover in diabetic 

heart (rat) 
POlHL-20552-02 0001 The development and regression of 
cardiac hypertrophy - Biochemical events in cardiac 
hypertrophy (rats) 
** ROlHL-21381-02 Ammo acid metabolism in normal and 
hypoxic myocardium (rabbits) 
ROlHL-2210102 Hormone-substrate interaction in diabetic 
myocyte (dogs, rats) 

AMINO ACIDS SEQUENCE 

SEE PROTEINS-PEPTIDES STRUCTURE, AMINO ACIDS 
SEQUENCE 
AMINO ACIDS TRANSPORT (GENERAL) 

SEE ALSO AMINO ACYL TRNA 
ROIHL 02835-21 Renal transport carrier for organic 

compounds (dogs, rats) 
ROlHL-04457-20 Cellular aspects of active transport (fish, 

rabbits, anurans. turtles) 
POIHL 06312-17 0034 Surgical cardiology ■ Metabolic 

factors in cardiac function-Creatine phosphate depletion 

(animals) 
POlHL-06370-17 0004 Cardiopulmonary and renal 

pathology research center - Lymphocytes in graft reiection 

and immune surveillance (human) 
ROlHL-09562-14 Cardiac protein synthesis, overload. 

alcohol and anoxia (guinea pigs) 
** ROlHL-13256-08 Ammo acid transport by red cell 

membranes (pigeons) 
P50HL-14212-07 0016 Correlated studies of pulmonary 

fibrosis - Role of pulmonary alveolar macrophages in 

fibrosis (human, rabbit) 
ROlHL-16567-04 Differentiation of the heart-cell 

membrane (mice, chick) 
RClHL-19394-03 Biochemistry and regulation of taurine in 

the heart (rats, guinea pigs, cats) 



AMI 



CtilulK in() inolKulii (tpcclt ol 
Filly icid mtltboli'.m in type II 



POIHI 19/3/0? 0001 
ie-,pii4lury phy,iolaiy 
alveolar crll% (ml-,) 
'* ROIHI 2U:il>(iOI Piolein lurnovei and amino acid 
llan^port by lung (rats) 
ROIHI 21009 02 rilecli of air pollutanl-, on lung cillt in 

culture (rats) 
ROIHI 221/201 Hypotension, itnal ischemia and elltct ol 
mannilol (dogs, rats) 
•• ROIHL 22354 01 Alpha adrenergic ellecti on heart 
metabolism (rats) 

AMINOACIDURIA INBORN 

Ml MIIAHOIII, DIMJUlJflC, INBORN, AMINOACIDOPATHIES 

AMINOACRIDINES 

S(f ACKIDINC, AMINOACRIDINES 

AMINO ACYL TRNA 

ROIHI 091/2 15 Protein and RNA synthesis in heart 

muscle (rats) 
ROIHL 20344 02 Regulation ol protein turnover in lung 
tissue (rals) 
AMINOACYLTRANSFERASES, 
TRANSGLUTAMINASES 

SFF ALSO BLOOD COAGULATION, FIBRIN STABILIZING FACTOR 
ROIHL 16346 09 En^me assay lor blood clotting (human) 

AMINO ALCOHOLS, ETHANOLAMINES 

SEE ALSO CHOLINE 

SEE ALSO PHOSPHOLIPIDS, PHOSPHOGIYCERIDES, 

PHOSPHATIOYL ETHANOUMINE 
SEE ALSO PHOSPHOLIPIDS, PHOSPHOGLYCERIDES. 

PUSMALOGENS 
ROIHL 22500 01 Conversion of choline to 
phosphatidylcholine in lung (rabbits, pigs) 

AMINO ALCOHOLS, PROPANOLS, ALPRENOLOL 

POIHL 06308 18 0025 Mechanisms and therapy of 

circulatory disease Subcellular calcium pools in the 

genesis of arrhythmias (dogs) 
ROIHL 19127 03 Synthesis of molecules for myocardial 

imaging (rats) 
ROIHL 20783 02 Airway reactivity B adrenoceptors and 

prostaglandins (guinea pigs) 
POlHL-20984 02 0005 Cellular mechanisms in cardiac 

hypertrophy Neurohumoral receptors in cardiac grovrth 

and compensatory hypertrophy (animals) 
ROIHL 22415 01 Mechanisms responsible for disease 

severity in asthma (human) 
ROIHL 22522 01 Cardioseledivity of beta-ad renoceptor 

antagonists 
P-AMINOBENZOATE, PROCAINE 
HYDROCHLORIDE 

SEE ALSO PHENYLAMIDES, PROCAINE AMIDE 
ROlHL-10503-13 Cardiac ion transport and ultrastructure 

(rats, guinea pigs, rabbits) 
R23HL-22895-01 Smoke inhalation- Biochemical and 

cellular responses (rabbits, bacteria) 

GAMMA-AMINOBUTYRIC ACID 

SEE AMINO ACIDS. GAMMA-AMINOBUTYRIC ACID 

AMINOFORMAMIDINE 

SEE GUANIDINES 
AMINOGLYCOLIPID (CERAMIDE TRIHEXISODE) 

SEE GLYCOSPHINGOLIPIOS, CERAMIDE TRIHEXOSIOES 

P-AMINOHIPPURATE 

SEE AMINO ACIDS, HIPPURATES. P AMINOHIPPURATE 

AMINOHYDROLASES 

SEE ALSO OXIDOREDUCTASES, AMINO ACID OXIDASES 
ROlHL-14456-07 Lung metabolism- Enzymes in the 
pulmonary circulation (human, animals) 
AMINOHYDROLASES, ADENOSINE DEAMINASE 
ROIHL 1294409 Enzymatic and biochemical studies on 

blood cells (human) 
ROlHL-15125 07 Molecular pathology of genetic disorders 
in man 
AMINOHYDROLASES, ADENYLATE DEAMINASE 
ROlHL-22538 01 Myosin as a multi-enzyme complex (dogs, 
rabbits) 

AMINOINDOLES 

SEE BENZOPYRROLES, INDOLEAMINES (GENERAL) 

ALPHA-AMINOISOBUTYRIC ACID 

SEE AMINO ACIDS, ALPHA AMINOISOBUTYRIC ACID 
ALPHA-AMINO,ALPHA-OXYACETIC ACID 

SEE OXAMATES 
AMINOPHYLLINE 

SEE PURINES. XANTHINES, AMINOPHYLLINE 
AMINOPOLYSACCHARIDES 

SEE POLYSACCHARIDES, GLYCOSAMINOGLYCANS 

BETA-AMINOPROPIONITRILE 

SEE CYANIDES. AMINOALKYL NITRILES. BAPN 

(contd) 



•Excludes routine methodology OR covers only general proiects which preclude 
**Oriented significantly to above subject 



indexing at the specific level 



M Grant has subproiects describing specific research aspects 
See Appendix for investigators name and grant number. 



P-A 

AMINOPYRIDINES 

SEE PYRIDINES, AMINOPYRIDINES 
P-AMINOSAUCYLATES 

SEE PHENYLCARBOXYLATES, SALICYUTES, PAMINO- 
AMINO SUGARS 

SEE CARBOHYDRATES, AMINO SUGARS 
AMINO SULFIDES, CYSTAMINE 

R01HL1363608 Effects of pharmacologic agents on heart 
metabolism (human, rodents) 

AMINOSULFONIC ACIDS 

SEE ALSO SULFONAMIDES 
R01HL18679-04 Synthetic protease inhibitors 
AMINOSULFONIC ACIDS, TAURINE 

ROlHL-09234-13 Amino acids of contractile proteins of 

falling hearts (dogs, hamsters) 
ROIHL 13636-08 Effects of pharmacologic agents on heart 

metabolism (human, rodents) 
ROlHL-18554-03 Taurine metabolism in mammalian heart 

(rodents, cattle, swine) 
ROlHL-19394-03 Biochemistry and regulation of taurine in 

the heart (rats, guinea pigs, cats) 

R01HL-202U-02 Role of taurine in the heart (dogs, rats 

mice) 

POlHL-20592-02 0003 Cell biology of cardiac and 
skeletal muscle Cellular magnesium and anion activities 
in ion-specific raicroelectrodes (frogs) 

AMINOTHIOLS, CYSTEAMINE 

POlHL-06370-17 0015 Cardiopulmonarv and renal 
pathology research center ■ Pathogenesis of chemically 
induced tissue injury (rats) 

ROIHL 1363608 Effects of pharmacologic agents on heart 
metabolism (human, rodents) 

AMINOTRANSFERASES, ALANINE 
TRANSAMINASE 

P01HL-06312-17 0053 Surgical cardiology - Enzyme 

pattern following cardiac surgery (human) 
ROlHL-22838-01 Post-transfusion hepatitis in newborn 

children 

AMINOTRANSFERASES, ASPARTATE 
TRANSAMINASE 

P01HL06312 17 0053 Surgical cardiology ■ Enzyme 

pattern following cardiac surgery (human) 
" ROlHL-1303508 Heart mitochondrial malate 

dehydrogenase regulation 
ROlHL-2226502 Isozymes of heart glutamate aspartate 

transaminase (swine, ducks) 

AMITRIPTYLINE 

SEE CYCLOHEPTANES. AMITRIPTYLINE 
AAUMONIA 

ROlHL-00759-29 Regulation of electrolyte and acid base 

equilibrium (dogs) 
R01HL12564-09 Control of respiration and blood gases 

(human, dog) 
R01HL-2138I02 Amino acid metabolism in normal and 

hypoxic myocardium (rabbits) 

AMMONIA-LYASES, ASPARTASE 

R01HL18288-04 Intraoperative protection of the 
myocardium (dogs, rats) 

AMMONIUM 

R01HL19746-03 Proliferation ?nd differentiation of 
alveolar macrophages (mice, hamsters) 

AMMONIUM QUATERNARY 

SEE ALSO CHOLINE 

SEE ALSO PHENYLALKYLAMINES, BENZYLAMINES, BRETYLIUM 
TOSYLATE 

SEE ALSO PHENYLAMINES, NEOSTIGMINE 
ROlHL-02835-21 Renal transport carrier for organic 

compounds (dogs, rats) 
RO1HL-I9782-02 Pharmacologic studies on the ischemic 

heart (dogs) 
ROlHL-20622-02 Pulmonary uptake and accumulation of 

drugs (rabbits, rats) 

AMMONIUM QUATERNARY, BETAINE 
COMPOUNDS, CARNITINE 

P01HL0630818 0040 Mechanisms and therapy of 

circulatory disease - Metabolism and fatty acid utilization- 
Heart electrical stability (rats, dogs) 

ROIHL 13028-09 Regulation of myocardial fatty acid 
metabolism (rats) 

R01HL13302-09 Uptake and metabolism of lipids by the 
liver (rats) 

R01HL1363608 Effects of pharmacologic agents on heart 
metabolism (human, rodents) 

ROIHL 14730-07 Fatty acid beta-oxidation in normal and 
ischemic hearts (rabbits) 

R01HL-1568I06 Coronary flow studies of partially 
obstructed vessels (dogs) 

ROIHL 17736-04 Metabolic change during cardiac 
ischemia (rats, dogs) 

ROlHL-20308-02 Regulation of myocardial acylcarnitine 
transport (rats) 



14 

ROIHL 2120902 Alterations of metabolism in ischemic 

myocardium (swine) 
ROlHL-228 13-01 Palmitylcarnitine inhibition of ion pumps 
in ischemia (dogs) 
*• ROlHL-2316101 0002 Biology of myocardial ischemia - 
Palmitylcarnitine inhibition of ion pumps in myocardial 
ischemia (dog, sheep) 

AiMMONIUM QUATERNARY, CHOLESTYRAMINE 

P01HL06835-17 0064 Cardiovascular disease ■ Studies 

in atherosclerosis (human, animals) 
ROlHL-08634-15 Enzymic cholesterol synthesis (human. 

rats, protozoa, yeast) 
R01HL1208510 Lipoprotein-carbohydrate metabolism 

(human, rats) 
P50HL 14230-07 0093 A/S SCOR-lipids, atherosclerosis 

and thrombosis ■ Clinical studies involving cellular lipid 

content (human) 
P50HL 14236-05 0009 Prevention of premature 

arteriosclerosis - Clinical studies on cholesterol metabolism 

(human) 
P50HL1506207 0018 Study of lipoproteins, artery wall. 

and atherosclerosis - Reversal of atherosclerosis in 

monkeys 
R01HL16364-04 Regulation of lipid biosynthesis and 

transport (rats, swine. Xenopus) 
ROlHL-16587-04 Cholesterol binding saponins and 

atherosclerosis (monkeys) 
R01HL17818-05 Metabolism of cholesterol and cholesterol 

in man (also rats, monkeys) 
R01HL18454-03 Maximal exercise testing in 

hypertipidemic children 
ROlHL-22567-01 Validation of a cholesterol absorption 

method in man 
NOlHV-22913-09 Lipid research clinic 

AMMONIUM QUATERNARY, 

TETRAETHYLAAAMONIUM COMPOUNDS 

R01HL1409207 Homeostatic regulation of plasma choline 
(rats, dogs, chickens) 

ROlHL-21371-02 Energy loss microanalysis of myocardial 
cations 

ROlHL-22426-01 Initiation of the heartbeat-A voltage- 
clamp study (bullfrogs, rabbits) 

ROlHL-22562-02 Mechanism of cardiac action potential 
propagation (tunicates) 

AMNIOCENTESIS 

SEE PREGNANCY, AMNIOCENTESIS 
AMP 

SEE ARTHRITIS AND METABOLIC DISEASES PROGRAM 

PROJECT COMMIHEE 
SEE PURINE NUCLEOTIDES. ADENINE NUCLEOTIDES, AMP 
AMP CYCLIC 

SEE PURINE NUCLEOTIDES. ADENINE NUCLEOTIDES AMP 
CYCLIC 

AMPHETAMINE 

SEE PHENYULKYLAMINES. AMPHETAMINE 
D-AMPHETAMINE 

SEE PHENYULKYUMINES, DAMPHHAMINE 
AMPHIBIANS, ANURANS* 

R01HL04457-20 Cellular aspects of active transport (fish, 

rabbits, anurans. turtles) 
R01HL13929-06 Single nephron response to chronic 

obstruction (frogs, rats) 
ROlHL-14523-07 Generation and regulation of force in 

smooth muscle (animals) 

AMPHOTERICIN-B 

SEE ANTIBIOTICS. AMPHOTERICINB 
AMPUTATION 

SEE SKELETAL SYSTEM, LIMB, AMPUTATION 
ALPHA-AM YLASE 

SEE CARBOHYDRASES, ALPHA-AMYLASE 
AMYL NITRITE 

SEE NITRITES, AMYL NITRITE 
AMYLOID SUBSTANCE 

SEE GLOBULINS, AMYLOID SUBSTANCE 

AMYLOIDOSIS (INCLUDING NON-INBORN 
CASES) 

SEE METABOLIC DISORDERS (INBORN). AMYLOIDOSIS 
ANABOLIC FACTORS 

SEE GROWTH FACTORS (INCL. ANABOLICS) 
ANAEROBES, BACTERIAL 

SEE MICROORGANISMS. ANAEROBES 
ANAEROBIC MICROORGANISMS 

SEE MICROORGANISMS. ANAEROBES 
ANAEROBIOSIS 

SEE RESPIRATION INTERNAL, ANAEROBIOSIS 
ANALGESICS 

SEE NEUROPHARMACOLOGICAL AGENTS, ANALGESICS 



•Excludes routine methodology OR covers only general projects which preclude indexing 
Onented significantly to above subject. 



AND 

ANALOGS OF HALOGENATED BIPHENYLS AND 
TRIPHENYLS 

SEE HALOBENZENES. HALOGENATED BIPHENYLSTRIPHENYLS 
AND ANALOGS 

ANALYSIS AND EVALUATION OF SYSTEMS 
(GENERAL) 

SEE INFORMATION AND COMMUNICATION, SYSTEMS ANALYSIS 
ANALYSIS OF BIOMEDICAL RESEARCH 
PROGRAMS 

SEE HEALTH SCIENCES RESEARCH ANALYSIS-EVALUATION- 
PLANNING 

ANALYSIS OF HEALTH CARE SERVICES AND 
RESOURCES 

SEE HEALTH CARE (SERVICES)(RESOURCES) ANALYSIS AND 
EVALUATION 

ANALYTICAL CHEMISTRY 

SEE CHEMISTRY. ANALYTICAL 
ANALYTICAL ELECTRON MICROSCOPY 

SEE CHEMISTRY. ANALYTICAL METHODS. SPECTROMETRY 
ELECTRON PROBE* 

ANALYTICAL METHODS 

SEE CHEMISTRY. ANALYTICAL METHODS* 
ANALYTICAL ULTRACENTRIFUGATION 

SEE PHYSICAL SEPARATION, ULTRACENTRIFUGATION 
ANALYTICAL* 

ANAPHYLAXIS 

SEE HYPERSENSITIVITY, ANAPHYLAXIS 
ANATOMY (GENERAL)* 

SEE ALSO BODY PHYSICAL CHARACTERISTICS (GENERAL) 
SEE ALSO NEUROANATOMY 
P01HL03 174-23 0007 Mechanisms of acute vascular 

reaction to injury ■ Healing of injured myocardium-Basal 

lamina scaffold (human, rats, dogs) 
POlHL-06312-17 0052 Surgical cardiology ■ Assay of 

metabolic variables of rat heart 
ROlHL-08359-14 Morphopharmacology of vascular 

adrenergic transmission (rabbits, rats) 
ROlHL-12486-10 Structure-function correlation in the 

atrium (rabbits) 
R01HL17969-04 Function and structure of semilunar 

valves (dogs) 
** POlHL-18575-03 0012 Mechanisms of vascular changes 

in hypertension ■ Anatomy core facility 
ROlHL-18639-03 Human anatomy for cardiac prostheses 

(human) 
R23HL-21253-01 Anatomical models in computer-aided 

image analysis 
ROlHL-22963-01 Symbolic logic analysis of congenital 

heart disease (human) 

ANATOMY MICROSCOPIC (HISTOLOGY) 

SEE HISTOLOGY (GENERAL)* 
ANDROGENS 

SEE ANDROSTANE SERIES. ANDROGENS 
ANDROMEDOTOXINS 

SEE TOXICOLOGY, PUNT POISONS, GRAYANOTOXINS 
ANDROSTANE SERIES, ANDROGENS 

ROlHL-03357-21 Humoral control of blood cell formation 

and release (rats, mice) 
ROlHL-0697518 Pathogenesis and prevention of 

hypertension (rats) 
ROlHL-17516-04 Role of androgen as a risk factor in 

atherogenesis (human, animals) 
ROlHL-17865-04 Studies on aging-Effects of sex 

hormones (rats, dogs) 
ROIHL- 17909-04 Drug treatment of vascular scleroprotein 

defects (human, turkeys) 
ROlHL-18012-04 Cellular defects in nocturnal 

hemoglobinuria (human) 
POlHL-18645-03 0007 Biology of the artery wall and 

atherosclerosis - Lipoprotein metabolism in subhuman 

primates 
ROlHL-21418-02 Experimental myocardial infarction (rats) 
ROlHL-22812-01 Regulation of hepatic production of HDL 

(rats) 

ANDROSTANE SERIES, ANDROSTANOLONE 

ROlHL-22040-01 Regulation of lysyl-cross-linking in 
vascular tissue (rats, turkeys) 

ANDROSTANE SERIES, ANDROSTENEDIOL 

P50HL-18318-03 0009 Pathogenesis and complications of 
hypertension - The mineralocorticoid-hypertensive syndrome 

in man 

ROlHL-18730-03 Role of mineralocorticoids in low renin 
hypertension (human, rats) 

ANDROSTANE SERIES, ANDROSTERONE 

P50HL-18323-04 0038 SCOR hypertension center - 

Unknown adrenocortical mechanisms in hypertension 
(human) 



at the specific level. 



M Grant has subprojecis describing specific research aspects. 
See Appendix for investigator's name and grant number 



(contd) 



.-Sff^jtt v4-jt^Atfb» A!ir> 



AND 

ANDROSTANE SERIES, 

OEHYOROEPIANDROSTERONE 

ROIHI 1810.' 11.' Kole ol Ihf .iilifnal corln in human 

hyp«r1ension 
PSOHl 18318 03 0004 Palhojenesis and complic«t(ons ot 

hypertension Sttcoid and lenin pcoliles in hypertension 

(Ills, human) 
PSOHL 18318 03 0009 Pathogenesis and complications ot 

hypertension The mineialocorticoid hypertensive syndrome 

in man 
ROIHI 18730 03 Role ol mineialocorticoids in low renin 

hypertension (hiinuin i.ils) 

ANDROSTANE SERIES, OXANDROLONE 

POIHI 185/4 03 0006 lipoprotein methodology and 
biomedical applications Lipoprotein transformation, 
lipolytic enzymes, diet and lipid lowering agents 

ROIHL 22607 01 Role ol apolipoprotem F in lipoprotein 
metabolism (human) 

ANDROSTANE SERIES, PANCURONIUM 

R?3HL 22309 01 Cardiovascular pharmacodynamics in 
immature dogs 
ANDROSTANE SERIES, TESTOSTERONE 

POIHI 16387 04 0002 The blood vessel and 

thrombogenesis Hormonal effects on thrombogenesis 

(rats, rabbits) 
ROIHL 1772104 Effect ol sex hormones on vascular 

connective tissue (rats) 
ROIHL 2036401 Episodic hypertension associated with 

human behavior (air traffic controllers) 

ANDRcSTANE SERIES 5 BETA, 
ETIOCHOLANOLONE 

P60HL15170 05 0017 Support for center for sickle cell 
anemia - Control of hemoglobulin synthesis (human) 

ANDROSTANOLONE 

SEE ANDROSTANE SERIES. ANDROSTANOLONE 

ANDROSTENEDIOL 

SEE ANDROSTANE SERIES. ANDROSTENEDIOL 

ANDROSTENOLONE 

SEE ANDROSTANE SERIES. OEHYOROEPIANDROSTERONE 

ANDROSTERONE 

SEE ANDROSTANE SERIES, ANDROSTERONE 

ANEMIA 

SEE BLOOD AND RE DISORDERS. ANEMIA 

ANEMIA APLASTIC 

SEE BLOOD AND RE DISORDERS. ANEMIA APUSTIC 

ANEMIA APLASTIC CONGENITAL 

SEE BLOOD AND RE DISORDERS. ANEMIA APUSTIC 
CONGENITAL 

ANEMIA HEMOLYTIC 

SEE BLOOD AND RE DISORDERS. ANEMIA HEMOLYTIC 

ANEMIA HEMOLYTIC AUTOIMMUNE 

SEE BLOOD AND RE DISORDERS, ANEMIA HEMOLYTIC 
AUTOIMMUNE 

ANEMIA HEMOLYTIC CONGENITAL (FAMILIAL) 

SEE BLOOD AND RE DISORDERS, ANEMIA HEMOLYTIC 
CONGENITAL (GENERAL) 

ANEMIA HEMOLYTIC IDIOPATHIC 

SEE BLOOD AND RE DISORDERS. ANEMIA HEMOLYTIC 
AUTOIMMUNE 

ANEMIA MEGALOBLASTIC 

SEE BLOOD AND RE DISORDERS. ANEMIA MEGALOBLASTIC 

ANEMIA SIDEROBLASTIC 

SEE BLOOD AND RE DISORDERS, ANEMIA SIDEROBUSTIC 

ANESTHESIA 

SEE SENSORY DEPRESSION, ANESTHESIA (GENERAL) 

ANESTHESIA, BLOCK 

SEE SENSORY DEPRESSION. ANESTHESIA CONDUCTION 

ANESTHESIA, CONDUCTION 

SEE SENSORY DEPRESSION, ANESTHESIA CONDUCTION 

ANESTHESIA, INHALATION 

SEE SENSORY DEPRESSION. ANESTHESIA (GENERAL). 
INHALATION 

ANESTHESIA, LOCAL 

SEE SENSORY DEPRESSION. ANESTHESIA CONDUCTION. 
LOCAL 

ANESTHESIA, REGIONAL 

SEE SENSORY DEPRESSION. ANESTHESIA CONDUCTION 

ANESTHESIA COMPLICATIONS 

SEE DISEASES, COMPLICATIONS. ANESTHESIA RELATED 

ANESTHETICS 

SEE NEUROPHARMACOLOGICAL AGENTS. ANESTHETICS 



M 

ANESTHETICS. LOCAL 

S(( NfUROPHARMACOIOGICAl AGENTS. ANESTHETICS. 
lOCAt 

ANEURYSM 

SI I (AHDIOVASCUIAR DISORDERS. ANEURYSM 

ANEURYSMS, CARDIAC 

SEE HEART DISORDfRS ANEURYSMS 

ANGER 

SEE PSYCHOLOGY, EMOTIONS. ANGER 

ANGER CAMERA SCANNING 

SEE RADIOAUTOGRAPHY RADIONUCLIDE SCANNING' 

ANGIITIS 

SEE CARDIOVASCUUR DISORDERS. ARTERITIS 

SEE CARDIOVASCULAR DISORDERS. THROMBOPHLEBITIS 

ANGINA, INTESTINAL 

SEE GASTROINTESTINAL CIRCULATORY DISORDERS. 
CIRCULATORY INSUFFICIENCY 

ANGINA PECTORIS 

SEE HEART DISORDERS. CORONARY. ANGINA PECTORIS 

ANGIOCARDIOGRAPHY 

SEE HEART VISUALIZATION, ANGIOCARDIOGRAPHY* 

ANGIOCARDIOULTRASONOGRAPHY 

SEE HEART VISUALIZATION. 

ANGIOCARDIOULTRASONOGRAPHY* 

ANGIOEDEMA HEREDITARY 

SEE METABOLIC DISORDERS INBORN. ANGIONEUROTIC 
EDEMA (HEREDITARY) 

ANGIOGENESIS 

SEE CARDIOVASCUUR SYSTEM. ANGIOGENESIS 

ANGIOGENESIS FACTOR, TUMOR 

SEE NEOPUSMS VASCUUR SUPPLY, TUMOR ANGIOGENESIS 
FACTOR 

ANGIOGRAPHY 

SEE CARDIOVASCUUR VISUALIZATION. ANGIOGRAPHY* 

ANGIOHEMOPHILIA 

SEE BLOOD COAGUUTION DISORDERS, VON VKILLEBRAND'S 
DISEASE 

ANGIOMA 

SEE NEOPUSMS OF CARDIOVASCUUR SYSTEM 

ANGIONEUROTIC EDEMA (HEREDITARY) 

SEE METABOLIC DISORDERS INBORN. ANGIONEUROTIC 
EDEMA (HEREDFTARY) 

ANGIOSPERMS (GENERAL) 

SEE PUNTS, ANGIOSPERMS (GENERAL)* 

ANGIOTENSIN 

SEE PEPTIDES, VASOACTIVE PEPTIDES. ANGIOTENSIN 

ANGIOTENSIN II 

SEE PEPTIDES. VASOACTIVE PEPTIDES, ANGIOTENSIN II 

ANGIOTENSINASE 

SEE PROTEASES AND PEPTIDASES, ANGIOTENSINASE 

ANGIOTENSINASE C 

SEE PROTEASES AND PEPTIDASES, 
PROLYLCARBOXYPEPTIDASE 

ANGIOTENSINOGEN 

SEE PEPTIDES, VASOACTIVE PEPTIDES. ANGIOTENSINOGEN 

ANGIOTENSINRENIN-ALDOSTERONE- 
ASSOCIATED HYPERTENSION 

SEE CARDIOVASCUUR DISORDERS. HYPERTENSION 
(SYSTEMIC), ANGIOTENSIN-RENIN-ALDOSTERONE- 
ASSOCIATED 

ANGIOTOMOGRAPHY 

SEE CARDIOVASCUUR VISUALIZATION. ANGIOTOMOGRAPHY* 

ANHYDRIDES 

SEE ETHERS 

SEE OXIDES (SEE ALSO SPECIFICS) 

ANIMAL AGE AND LIFE STAGES 

SEE AGE (ANIMAL) 

ANIMAL BEHAVIOR 

SEE PSYCHOLOGY. BEHAVIOR ANIMAL 

ANIMAL CARE 

SEE ANIMALS. VETERINARY SCIENCE. ANIMAL CARE 

ANIMAL FACILITIES, RESOURCES 

SEE ALSO ANIMALS. VETERINARY SCIENCE 
SEE ALSO MAMMALS. PRIMATE COLONIES 
** N01HB-42971-I2 Chimpanzees for hepatitis research 
** POIHL-12373 10 0019 Cardiopulmonary physiology and 

pathophysiology - Free ranging animal facility 
** P50HL-14164-07 0025 A/S SCOR -Comparative and 
experimental atherosclerosis - Animal care resource and 
laboratory animal medicine unit (monkeys, pigeons) 



•Excludes routine methodology OR covers only general projects which prccludi 
**Orlenled significantly to above subject, 



ie indexing at the specific level 



M Grant has subprojects describing specific 

See Appendix for investigator's name and grant number 



ANO 

P'jOHI 14164 0/ n0?8 A/S SCOR Comparative and 

eiperimenlal atheroscliiosis Hyper and 

hyporisponsiveniit to ditliry choleilirol (Alitcan grMn 

monkey) 
P50HI 14164 0/ 0029 A/S SCOR Comparalive and 

experimental atheroulerotit DtvelopmenI of pigeon 

substrains 
•• P'jOHl 14214 0/ 00)5 Newborn lung center lor hyaline 

membrane disease Coir Animal care lacilily 
*" POIHI 149850/001/ Adaptation to hypoxia Core 

laboratories 
P50HI 1506? 0/ 0021 Study of lipoproteins, artery wall. 

and alhrioscleiosi'. Core laboratcjries 
•• POIHI 15194 0/ 9000 Psihophy.iology ol 

caidiopulmonary dysfunction Animal laboratory core 
•• ROIHL 1564/06 Hematopoietic studies ol cyclic 

hemalopoiesis (dogs) 
•* P60HI 1/269 04 0024 National heart and blood vessel 

rpse^iich and -r - ' ■'•■- ■ ' '' ""eclion ol 

experimenlaUo , ,.eiy Core facility 

*• P50HL 1/646 04 0004 Study of ischemic heart disease 

Core experimental animal laboratories 
** P50HL 18318 03 0002 Pathogenesis and complications ol 

hypertension Core experimental animal facility (rats, 

rabbits) 
•* POIHL 18575 03 0010 Mechanisms of vascular changes 

in hypertension Hypertensive pig Core 
•* POIHL 20993 02 0010 Population dynamics of arterial 

cells in atherogenesis Animal care and development and 

standardization ol animal models Core 
** ROIHL 22227 01 A new '.ource of hyaluronidase and 

anticoagulants (leeches) 
** NOIHV 72978 02 Development of models of hypertension 
** NOIHV 7298002 Development of models of hypertension 

ANIMAL HUSBANDRY 

SEE ANIMALS. VETERINARY SCIENCE 

ANIMAL POISONS 

SEE TOXICOLOGY, ANIMAL POISONS 

ANIMALS (SEE SPECIFIC ANIMALS) 

SEE AGE (ANIMAL) 

SEE AGE (ANIMAL), INFANTS MORTALITY 

SEE ENVIRONMENT, ECOLOGY ANIMAL 

SEE GENETICS. POPUUTION GENETICS ANIMAL 

SEE PSYCHOLOGY, BEHAVIOR ANIMAL 

ANIMALS, CHORDATES, VERTEBRATES* 

SEE ALSO BIROS* 
SEE ALSO FISH* 
SEE ALSO MAMMALS* 
SEE ALSO REPTILES* 
ROIHL 1999502 Sensory transduction m cardiac 

mcchanoreceptors (cats, frogs, rats) 
ROlHL-22562-02 Mechanism of cardiac action potential 
propagation (tunicates) 
ANIMALS, VETERINARY MEDICINE 

SEE ALSO POPUUTION STUDIES ANIMAL. EPIZOOTIOLOGY 
P50HL14164-07 0025 A/S SCOR- Comparative and 
experimental atherosclerosis Animal care resource and 
laboratory animal medicine unit (monkeys, pigeons) 
** ROlHL-18947-02 Indirect mean arterial pressure 
(mammals) 
P50HL-19187-02 0013 Pediatric pulmonary SCOR Hyaline 

membrane disease - Research resources core 
P50HL-19362-02 0004 A/S SCOR -Atherosclerosis in 
nonhuman primates - Selective breeding for characters 
related to atherosclerosis (baboons) 
** P50HL-19362-02 0016 A/S SCOR- Atherosclerosis in 
nonhuman primates - Core laboratory -Animal services 
(baboon) 
ANIMALS, VETERINARY SCIENCE 
SEE ALSO ANIMAL FACILITIES. RESOURCES 
ROlHL-13645 U Tryptophan-induced pulmonary 
emphysema (cattle, goats, rabbits) 
** POlHL-14388-07 9001 Regulation of the circulation in 
pathological states - Core facility for hypertensive animal 
colony (rats) 
NOlHV-62905-02 Non-human primate models of 
arteriosclerosis 

ANIMALS, VETERINARY SCIENCE, ANIMAL CARE 

** NOlHI-72900-01 Maintenance of the NHLBI sheep colony 
P50HL-14164-07 0025 A/S SCOR -Comparative and 

experimental atherosclerosis - Animal care resource and 

laboratory animal medicine unit (monkeys, pigeons) 
P50HL-1421407 0035 Newborn lung center for hyaline 

membrane disease - Core-Animal care facility 
POlHL-14388-07 9001 Regulation of the circulation in 

pathological states - Core facility for hypertensive animal 

colony (rats) 
" P50HL-19362-02 0016 A/S SCOR -Atherosclerosis in 

nonhuman primates ■ Core laboratory -Animal services 

(baboon) 

ANION 

SEE IONS. ANION 

ANOREXIA 

SEE NUTRIENT INTAKE DISORDERS, APPETITE DISORDERS, 
ANOREXIA 

(contd) 
research aspects 



ANO 

ANOREXIGENIC DRUGS 

SEE NUTRIENT INTAKE ACTIVITY. APPETITE DEPRESSANTS 
ANOXIA 

SEE RESPIRATORY GAS LEVELS, HYPOXIA 
ANOXIA NEONATORUM 

SEE RESPIRATORY GAS LEVELS. HYPOXIA NEONATORUM 
ANOXIA RESPIRATORY 

SEE RESPIRATORY GAS LEVELS. HYPOXIA. RESPIRATORY 
ANTAGONISM 

SEE DRUGS AND PHYSICAL AND/OR CHEMICAL AGENTS 
INTERACTION 

SEE DRUGS INTERACTION 

SEE PHYSICAL AND/OR CHEMICAL AGENTS INTERACTION 
(BIOLOGICAL AND ECOLOGICAL) 

ANTEPARTUM DIAGNOSIS 

SEE PREGNANCY. ANTEPARTUM DIAGNOSIS 
ANTHOZOA 

SEE COELENTERATES. ANTH020A* 
ANTHROPOLOGY, PHYSICAL 

SEE BODY PHYSICAL CHARACTERISTICS (GENERAL) 
ANTHROPOMETRY 

SEE BODY PHYSICAL CHARACTERISTICS (GENERAL) 
ANTIACIDOSIS DRUGS 

SEE BODY FLUID BAUNCE. ACID-BASE. ANTIACIDOSIS DRUGS 
ANTIADRENERGICS 

SEE NEUROPHARMACOLOGICAL AGENTS. SYMPATHOLYTIC 
ANTIALIERGY DRUGS 

SEE HYPERSENSITIVITY. ANTIALLERGY DRUGS 
ANTI-ANTIBODIES 

SEE IMMUNOLOGY, ANTIBODIES. ANTI-ANTIBODIES 
ANTIARRHYTHMIC AGENTS 

SEE CARDIOVASCULAR AGENTS. ANTIARRHYTHMIC AGENTS 
ANTIATHEROGENIC AGENTS 

SEE CARDIOVASCUUR AGENTS. ANTIATHEROGENIC AGENTS 
ANTIBACTERIAL AGENTS 

SEE COMMUNICABLE DISEASE CONTROL AGENTS 
ANTIBACTERIAL 

ANTIBIOTICS 

SEE ALSO COMMUNICABLE DISEASE CONTROL AGENTS 
ROlHL-12528-10 NMR relaxation of liquid ciystal systems 
ROlHL-14775-08 Mechanisms of drug action in vascular 

smooth muscle (dog. rabbits) 
R01HL-I5619-05 Regulation of prothrombin synthesis In 

cultured cells (rats) 
ROlHL-16474-05 Antibiotic-ion interactions (model 



membranes) 
ROlHL-17751-03 
ROlHL-18002-03 

function (rats) 
ROlHL-19722-03 

(models) 
ROlHL-19818-02 

(rabbits, human) 
ROlHL-20963-01 
ROlHL-22888-01 



Experimental endocarditis (rabbits) 
Circulatory shock, trauma and RE-system 

Aerosol growth in the respiratory system 

Endocarditis on prosthetic heart valves 

Experimental lung abscess (rabbits) 
Prosthetic valve endocarditis -Etiology 



and therapy (dogs) 

ANTIBIOTICS, ACTINOMYCIN 

POlHL-06314-17 0064 Immunologic mechanisms in 

cardiovascular disease - Diabetic vascular disease (human, 
rats, mice) 

ANTIBIOTICS, ACTINOMYCIN D 

POlHL-06370-17 0004 Cardiopulmonary and renal 

pathology research center - Lymphocytes in graft rejection 

and immune surveillance (human) 
POIHL-14388-07 0190 Regulation of the circulation in 

pathological states • Mechanisms of the renal actions of 

aldosterone (rats) 

ANTIBIOTICS, AORIAMYCIN 

POlHL-06370-17 0014 Cardiopulmonary and renal 
pathology research center - Quantitative morphology in 
cardiac disease (human, rats, dogs) 

ROlHL-13636-08 Effects of pharmacologic agents on heart 
metabolism (human, rodents) 

ANTIBIOTICS, AMPHOTERICIN-B 

R01HL-16660-06 Phospholipid-cholesterol and 
phospholipidprotein interactions 

ANTIBIOTICS, ANTINEOPLASTIC ANTIBIOTICS 
(GENERAL) 

SEE ALSO ANTIBIOTICS. ACTINOMYCIN 
SEE ALSO ANTIBIOTICS. ACTINOMYCIN D 
SEE ALSO ANTIBIOTICS, ADRIAMYCIN 
SEE ALSO ANTIBIOTICS, BLEOMYCIN 
SEE ALSO ANTIBIOTICS, DAUNOMYCIN 
SEE ALSO ANTIBIOTICS, KANAMYCIN 
SEE ALSO ANTIBIOTICS, MITOMYCIN C 
ROlHL-18606-04 Pathogenesis and measurement of 
pulmonary edema (human, rabbits, dogs) 



16 

ANTIBIOTICS, BACITRACIN 

RC1HL-16101-05 Protein-lipid interaction (bacteria, 
models) 

ANTIBIOTICS, BLEOMYCIN 

POIHL 161 18 06 0003 Study of emphysema - Degradation 

of collagen and elastin (human, hamsters, mice) 
R01HL18606 04 Pathogenesis and measurement of 

pulmonary edema (human, rabbits, dogs) 
POlHL-19717-02 0008 Response of the lung to injury - 

Experimental models of lung disease 
R01HL19720-03 Evaluation of antifibrotic agents in 

pulmonary fibrosis (rats) 

ANTIBIOTICS, DAUNOMYCIN 

ROlHL-20856-02 Platelet transfusions-Usage and 
complications (human) 

ANTIBIOTICS, FILIPIN 

ROlHL-16660-06 Phospholipid-cholesterol and 

phospholipidprotein interactions 
ROlHL-2205201 Organization of free cholesterol in serum 

lipoproteins (human, dogs) 

ANTIBIOTICS, GENTAMICIN 

ROIHL 14775-08 Mechanisms of drug action in vascular 
smooth muscle (dog. rabbits) 

ANTIBIOTICS, GRAMICIDIN (UNSPECIFIED) 

ROlHL-12528-10 NMR relaxation of liquid crystal systems 
R01HL13256-08 Amino acid transport by red cell 
membranes (pigeons) 

ANTIBIOTICS, KANAMYCIN 

ROlHL-2257301 Treatment of post surgical 
vasoconstriction (dogs, monkeys, human, rats) 

ANTIBIOTICS, MITOMYCIN C 

ROlHL-08696-15 0013 Orthotopic heart transplantation - 
Transplantation immunology-Cardiac heterotransplantation 
(rabbits, dogs) 

ANTIBIOTICS, NEOMYCIN 

P50HL14236-05 0009 Prevention of premature 

arteriosclerosis - Clinical studies on cholesterol metabolism 
(human) 

ROlHL-22567-01 Validation of a cholesterol absorption 
method in man 

ANTIBIOTICS, NOVOBIOCIN 

ROlHL-1569812 Factors affecting the action of 
anticoagulants (rats, human) 

ANTIBIOTICS, NYSTATIN 

ROlHL-16660-06 Phospholipid-cholesterol and 
phospholipidprotein interactions 

ANTIBIOTICS, OLIGOMYCIN 

R01HL19378-03 Relation of mitochondrial changes to 
cardiac failure (dogs, rats) 

ANTIBIOTICS, PENICILLIN 

P60HL15996-06 0003 Cincinnati comprehensive sickle 
cell center - Prophylactic penicillin in treatment of sickle 
cell anemia (human) 

ROlHL-201 70-02 Pulmonary infection in splenectom ized 
animals (mice) 

ANTIBIOTICS, PENICILLIN G 

R23HL-2289501 Smoke inhalation -Biochemical and 
cellular responses (rabbits, bacteria) 

ANTIBIOTICS, RISTOCETIN A 

P50HL142 17-08 0058 Specialized center of research in 

thrombosis ■ Mechanisms of induction and inhibition of 

platelet reaction (human, pig) 
P50HL14217-08 0062 Specialized center of research in 

thrombosis - Coagulation section -Factor VIII and Factor XII 

(human, cattle) 
ROlHL-15230-05 Molecular basis of V Willebrand's disease 

and hemophilia (human, cattle) 
POlHL-15596-05 0014 Coagulation, fibrinolysis. 

hemostasis and hepatitis • Von Willebrand factor and 

platelet retention in glass bead columns (swine) 
POlHL-17430-05 0001 Control of coagulation ■ Porcine 

von Willebrand's disease 
** P01HL17430-05 0002 Control of coagulation ■ Isolation 

of ristocetin-von Willebrand factor (swine) 
P50HL-18828-03 0001 Specialized center of research in 

thrombosis - Membrane biology and hemostasis (human) 
ROlHL-19278-03 Ristocetin induced platelet aggregation 

(human) 
ROlHL-20517-03 Diabetes, somatotropin, factor VIII and 

atherosclerosis (human, animal) 

ANTIBIOTICS, VALINOMYCIN 

R01HL12528-10 NMR relaxation of liquid crystal systems 
ROlHL-23392-01 Membrane binding and transport of 
calcium and potassium ionophores 

ANTIBIOTICS, VANCOMYCIN 

R01HL19278-03 Ristocetin induced platelet aggregation 
(human) 

ANTIBODIES 

SEE IMMUNOLOGY, ANTIBODIES 



ANT 
ANTIBODIES, BACTERIAL 

SEE IMMUNOLOGY, ANTIBODIES BACTERIAL 
ANTIBODIES, FUNGAL 

SEE IMMUNOLOGY, ANTIBODIES FUNGAL 
ANTIBODIES, VIRAL 

SEE IMMUNOLOGY, ANTIBODIES VIRAL 
ANTIBODIES NEOPLASTIC 

SEE NEOPWSMS IMMUNOLOGY, TUMOR ANTIBODIES 
ANTIBODIES SENSITIZING HUMORAL 
(CIRCULATING) (SERUM) 

SEE HYPERSENSITIVITY. SENSITIZING ANTIBODIES HUMORAL 
ANTIBODIES TO MICROBIAL TOXINS 

SEE IMMUNOLOGY. ANTITOXINS 

ANTIBODY-ANTIGEN REACTIONS 

SEE IMMUNOLOGY. ANTIGEN-ANTIBODY REACTIONS 

ANTIBODY-ANTIGEN REACTIONS IN VITRO 

SEE IMMUNOLOGY. SEROLOGY* 

ANTIBODY BIOSYNTHESIS 

SEE IMMUNOLOGY. ANTIBODY FORMATION 
ANTIBODY FORMATION 

SEE IMMUNOLOGY. ANTIBODY FORMATION 
ANTIBODY SPECIFICITY 

SEE IMMUNOLOGY. ANTIBODY SPECIFICITY 
ANTIBODY STRUCTURE 

SEE GLOBULINS. GAMMA GLOBULINS. IMMUNOGLOBULIN 
STRUCTURE 

ANTICHOLINERGIC AGENTS 

SEE NEUROPHARMACOLOGICAL AGENTS, 
PARASYMPATHOLYTIC 

ANTICOAGULANTS 

SEE BLOOD COAGULATION. ANTICOAGULANTS 
ANTICONVULSANTS 

SEE NEUROPHARMACOLOGICAL AGENTS. ANTICONVULSANTS 
ANTIDEPRESSANTS 

SEE PSYCHOPHARMACOLOGICAL AGENTS, ANTIDEPRESSANTS 
ANTIDIURESIS 

SEE KIDNEY FUNCTION, ANTIDIURESIS 
ANTIDIURETIC HORMONE 

SEE PITUITARYDIENCEPHALON HORMONES. VASOPRESSIN 
ANTIDIURETICS 

SEE KIDNEY FUNCTION, ANTIDIURETICS 
ANTIDROMIC IMPULSES 

SEE NEUROPHYSIOLOGY, NEURAL TRANSMISSION 
ANTIDROMIC IMPULSES 

ANTIESTERASES 

SEE ENZYME INHIBITORS, ANTIESTERASES 
ANTIFERTILITY DRUGS 

SEE FERTILITY, ANTIFERTILITY DRUGS 
ANTIFIBRINOLYTIC AGENTS 

SEE BLOOD COAGUUTION, ANTIFIBRINOLYTIC AGENTS 

ANTIFUNGAL AGENTS 

SEE COMMUNICABLE DISEASE CONTROL AGENTS 
ANTIFUNGAL 

ANTIFUNGAL ANTIBODIES 

SEE IMMUNOLOGY, ANTIBODIES FUNGAL 
ANTIGEN-ANTIBODY REACTIONS 

SEE IMMUNOLOGY, ANTIGEN-ANTIBODY REACTIONS 

ANTIGEN-ANTIBODY REACTIONS IN VITRO 

SEE IMMUNOLOGY, SEROLOGY* 

ANTIGENS 

SEE IMMUNOLOGY, ANTIGENS 
ANTIGENS BACTERIAL 

SEE IMMUNOLOGY, ANTIGENS BACTERIAL 
ANTIGENS FUNGAL 

SEE IMMUNOLOGY. ANTIGENS FUNGAL 
ANTIGENS HELMINTHIC 

SEE IMMUNOLOGY. ANTIGENS HELMINTHIC 
ANTIGENS NEOPLASTIC 

SEE NEOPLASMS IMMUNOLOGY, TUMOR ANTIGENS 
ANTIGENS VIRAL 

SEE IMMUNOLOGY. ANTIGENS VIRAL 

ANTIGOUT DRUGS 

SEE PURINESPYRIMIDINES METABOLISM ERRORS, GOUT 
DRUGS 

ANTI-H BLOOD GROUP (BOMBAY) 

SEE BLOOD GROUPS, BOMBAY 



•Excludes routine methodology OR covers only general projects which preclude indexing 
'Oriented significantly to above subject. 



at the specific level. 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



(contd) 



;«^ 



ANT 

ANTIHEMOPHILIC FACTOR 

Slf BlOOn COACUIAIION, lACIOR VIII 

ANTIHEMOPHILIC FACTOR A 

Sff BlOOn COACmAIION (ACIOR VIII 

ANTIHEMOPHILIC FACTOR B 

Sri BlOOn C0A(UIIA1I0N t ACIOR IX 

ANTIHEMOPHILIC FACTOR C 

Sfi BIOOD COACIIIAIION, (ACTOR XI 

ANTIHEMOPHILIC GLOBULIN 

SEE BLOOD COAGUIAIION. FACTOR VIII 

ANTIHISTAMINES 

Stf HYPERSENSITIVITY. ANTIALIERGY DRUGS. HISTAMINE 
ANTAGONISTS 

ANTIHYPERTENSIVE AGENTS 

SEE CAROIOVASCUUR AGENTS. ANTIHYPERTENSIVE AGENTS 

ANTIINFECTIVE AGENTS 

SEE COMMUNICABlt DISEASE CONTROL AGENTS 

ANTIINFECTIVE AGENTS, ANTIBACTERIAL 

SEE COMMUNICABLE DISEASE CONTROL AGENTS. 
ANTIBACTERIAL 

ANTIINFLAMMATORY AGENTS 

SEE DISEASES. PATHOLOGIC PROCESSES. INFUMMATION. 
ANTMNFUMMATORY AGENTS 

ANTILEUKOCYTIC SERA 

SEE IMMUNITY. IMMUNOSUPPRESSION. ALLOANTISERA. 
ANTILEUKOCYTIC 

ANTILYMPHOCYTIC SERA 

SEE IMMUNITY. IMMUNOSUPPRESSION. ALLOANTISERA. 
ANTILEUKOCYTIC 

ANTIMALARIALS 

SEE COMMUNICABLE DISEASE CONTROL AGENTS. 

ANTIMALARIALS 

ANTIMETABOLITES 

SEE ALSO ANTIBIOTICS 
SEE ALSO ANTIMITOTIC AGENTS 
SEE ALSO ENZYME INHIBITORS 

SEE ALSO NEOPLASTIC THERAPY. ANTINEOPLASTIC AGENTS 
SEE ALSO THYROID ANTAGONISTS 
R01HL1190611 Comparative study nf heart function 

(cats. rats, hedgehogs, squirrels) 
R01HL1561905 Regulation of prothrombin synthesisin 

cultured cells (rats) 
POlHL-1973702 0011 Cellular and molecular aspects of 
respiratory physiology ■ Chemical and metabolic factors on 
peripheral chemoreceptor activity (cats) 
R23HL-21853-01 Lung metabolism and alveolo-capillaiy 

permeability (rats) 
ROlHL-22873-01 Adrenoceptor interconversion and 
hormone homeostasis 

ANTIMETABOLITES, ANTINEOPLASTIC 

SEE NEOPLASTIC THERAPY. ANTINEOPLASTIC AGENTS 

ANTIMICROBIAL AGENTS 

SEE COMMUNICABLE DISEASE CONTROL AGENTS 

ANTIMITOTIC AGENTS 

SEE ALSO ANTIMETABOLITES 
POlHL-16387-04 0003 The blood vessel and 

thrombogenesis - Blood vessel healing (rabbits) 
R01HL-1643705 Drug treatment of atherosclerosis 

(rabbits, monkeys) 
R01HL-20826-02 Megakaryocyte proliferation and its 

control (mice) 

ANTIMUSCARINIC AGENTS 

SEE NEUROPHARMACOLOGICAL AGENTS, 
PARASYMPATHOLYTIC 

ANTIMYCOTIC AGENTS 

SEE COMMUNICABLE DISEASE CONTROL AGENTS. 
ANTIFUNGAL 

ANTINEOPLASTIC AGENTS 

SEE NEOPLASTIC THERAPY. ANTINEOPUSTIC AGENTS 

ANTINEOPLASTIC ANTIBIOTICS 

SEE ANTIBIOTICS. ANTINEOPLASTIC ANTIBIOTICS (GENERAL) 

ANTIOXIDANTS 

SEE OXIDANTS. ANTIOXIDANTS 

ANTiPARKINSON DRUGS 

SEE NEUROPHARMACOLOGICAL AGENTS. ANTIPARKINSON 
DRUGS 

ANTIPERNICIOUS ANEMIA PRINCIPLE 

SEE VITAMIN B12 

ANTIPYRETICS 

SEE NEUROPHARMACOLOGICAL AGENTS. ANALGESICS. 
ANTIPYRETICS 

ANTIRENIN 

SEE PEPTIDES. VASOACTIVE PEPTIDES. ANTIRENIN 



I / 



ANTIRHEUMATIC AGENTS 

SI I CDNNIl IIVI IISSUI DISUHDIK". Hill UMAIlt 
DISOHDIHS. ANIIRHIUMAIIC AGENTS 

ANTISPASMODICS 

Sff MUSCll RflAXANTS. ANTISPASMODICS 

ANTITHROMBIN 

SFI BIOOD COAGUIATION. ANTITHROMBIN 

ANTITHROMBIN I 

SIE BLOOD COAGUIATION. fIBRIN 

ANTITHROMBIN II 

SEE BIOOD COAGUIATION. HEPARIN CO FACTOR 

ANTITHROMBOGENIC SURFACE 

SEE BLOOD COAGUIATION. ANTITHROMBOGENIC SURFACE 

ANTITHYMOCYTIC SERA 

SEE IMMUNITY, IMMUNOSUPPRESSION. ALLOANTISERA, 
ANTILEUKOCYTIC 

ANTITHYROID COMPOUNDS 

SEE THYROID ANTAGONISTS 

ANTITOXINS 

SEE IMMUNOLOGY. ANTITOXINS 

ANTITRYPSIN DEFICIENCY 

SEE METABOLIC DISORDERS (INBORN), ANTITRYPSIN 
DEFICIENCY 

ANTITRYPSIN INHIBITORS 

SEE ENZYME INHIBITORS. TRYPSIN INHIBITORS. ANTITRYPSIN 

ALPHA-1 -ANTITRYPSIN INHIBITORS 

SEE ENZYME INHIBITORS. TRYPSIN INHIBITORS. ANTITRYPSIN 

ANTIVIRAL AGENTS 

SEE COMMUNICABLE DISEASE CONTROL AGENTS, ANTIVIRAL 

ANTIVIRAL ANTIBODIES 

SEE IMMUNOLOGY, ANTIBODIES VIRAL 

ANTIVITAMINS 

SEE VITAMIN ANTAGONISTS 

ANURIA 

SEE KIDNEY DISORDERS. ANURIA 

ANXIETY 

SEE PSYCHOLOGY. EMOTIONS. ANXIETY 

AORTA 

SEE CAROIOVASCUUR SYSTEM. ARTERIES. AORTA 

AORTA COARCTATION 

SEE CARDIOVASCULAR DISORDERS, AORTA OBSTRUCTIONS, 
AORTA COARCTATION 

AORTA DISORDERS (GENERAL) 

SEE CARDIOVASCULAR DISORDERS, AORTA DISORDERS 
(GENERAL) 

AORTA OBSTRUCTION 

SEE CAROIOVASCUUR DISORDERS, AORTA OBSTRUCTIONS 

AORTIC ANEURYSM 

SEE CAROIOVASCUUR DISORDERS, AORTIC ANEURYSM 

AORTIC BALLOON PUMPING 

SEE HEART PROSTHESIS. AUXILIARY, AORTIC BALLOON 
PUMPING 

AORTIC BODY 

SEE NERVOUS SYSTEM, PARAGANGLIA, AORTIC BODY 

AORTIC INSUFFICIENCY 

SEE HEART DISORDERS, VALVULAR INSUFFICIENCY, AORTIC 
INSUFFICIENCY 

AORTIC VALVE 

SEE HEART, VALVES, AORTIC VALVE 

AORTIC VALVE DISORDERS 

SEE HEART DISORDERS, VALVULAR, AORTIC VALVE 
DISORDERS 

AORTIC VALVE STENOSIS 

SEE HEART DISORDERS, VALVULAR. AORTIC VALVE STENOSIS 

AOTES 

SEE MAMMALS. PRIMATES. MONKEYS AND APES 

(ANTHROPOIDS, NON-HUMAN), NEW WORLD MONKEYS 
(PLATYRHINES)* 

APC AGENTS 

SEE VIRUSES, ADENOVIRUSES 

APLASTIC ANEMIA 

SEE BLOOD AND RE DISORDERS, ANEMIA APUSTIC 

APLASTIC ANEMIA CONGENITAL 

SEE BLOOD AND RE DISORDERS, ANEMIA APUSTIC 
CONGENITAL 

APNEA 

SEE RESPIRATORY FUNCTION, APNEA 

APOENZYMES 

SEE ENZYMES, APOENZYMES 



APOPLEXY 

Ml (.IRFBROVASCUIAR DISORDFRS, SIROKF 

APPENDAGES 

M I '.Kill lAI ',Y',IIM IIMH 

APPETITE DEPRESSANTS 

Ml NIIIHIINI INIAKI Al.llVliy ACCdIK 01 I'd ','.ANC, 

APPETITE REVERSING FACTOR, PITUITARY 

Ml lll'll) M(|I)III/IN(, lAr.KlM', PIMIIIAKY 
APPLIED PHYSIOLOGY AND ORTHOPEDICS 
STUDY SECTION 
SEE PHYSIOIOCY (APPII(D) AND ORTHOPEDIC, STUDY 
SECTION 

APPOINTMENTS AND VISITS (PATIENTS) 

SEE HFAITH CARF (SfRVICf S)(RESOURCFSI UTIIIZAIION. 
APPOINIMFNIS VISITS 

AQUATIC BIOLOGY 

SEE WATER FNVIHONMENI, AOUAIIC BIOLOGY 

AQUATIC ORGANISMS, FRESH WATER 

SEE WATER ENVIRONMENT, AQUATIC ORGANISMS. FRESH 
WATER- 
AQUEOUS HUMOR 

SEE EYE, AQUEOUS HUMOR 

AQUEOUS SOLUTIONS 

SEE PHYSICAL PROPERTIES, SOLUTIONS, AQUEOUS 

ARA-C 

SEE PYRIMIDINE NUCLEOSIDES, CYTOSINE NUCLEOSIDES. 
CYTOSINE ARABINOSIOE 

ARACHIDONIC ACID 

SEE FAHY ACIDS, ARACHIDONIC ACID 

ARACHNIDISM 

SEE TOXICOLOGY, ANIMAL POISONS, ARTHROPOD, SPIDER 

ARACHNODACTYLY 

SEE METABOLIC DISORDERS INBORN, MARFAN SYNDROME 

ARBOVIRUSES (GENERAL) 

SEE VIRUSES, ARBOVIRUSES (GENERAL) 

ARO AGENTS 

SEE VIRUSES, ADENOVIRUSES 

AREA POSTREMA 

SEE BRAIN, MEDULU OBLONGATA, AREA POSTREMA 

AREAWIDE MEDICAL PLANNING 

SEE HEALTH CARE (SERVICES)(RESOURCES)PLANNING, 
REGIONAL MEDICAL PUNNING 

ARENAVIRUSES 

SEE VIRUSES, ARENAVIRUSES 

ARGENTAFFINOMA 

SEE NEOPUSMS OF NERVOUS SYSTEM, CARCINOID 

ARGININE 

SEE DIAMINO ACIDS, ARGININE 

ARGININE ESTERASE 

SEE CARBOXYLIC ESTER HYOROUSES, ARGININE ESTERASE 

ARGININE VASOPRESSIN 

SEE PITUITARY-DIENCEPHALON HORMONES, VASOPRESSIN. 
ARGININE VASOPRESSIN 

ARM 

SEE SKELETAL SYSTEM. LIMB. ARM 

AROUSAL 

SEE PSYCHIC ACTIVITY LEVEL. AROUSAL 

ARRHYTHMIA, CARDIAC 

SEE HEART DISORDERS. ARRHYTHMIA 

ARRHYTHMIC AGENTS 

SEE CAROIOVASCUUR AGENTS. ARRHYTHMIC AGENTS 

ARTERENOL 

SEE PHENYULKYUMINES. CATECHOUMINES. 
NOREPINEPHRINE 

ARTERIAL FIBROSIS 

SEE HEART DISORDERS. CORONARY FIBROSIS 

ARTERIAL INFUSIONS 

SEE DOSAGE AND ROUTE. INFUSIONS ARTERIAL 
ARTERIAL OCCLUSIONS 

SEE CAROIOVASCUUR DISORDERS. ARTERIAL OCCLUSIONS 

ARTERIES 

SEE CAROIOVASCUUR SYSTEM. ARTERIES 

ARTERIAL STENOSIS 

SEE CAROIOVASCUUR DISORDERS, ARTERIAL STENOSIS 

ARTERIOLES 

SEE CAROIOVASCUUR SYSTEM, ARTERIOLES 

ARTERIOSCLEROSIS 

SEE CAROIOVASCUUR DISORDERS, ARTERIOSCLEROSIS 

(contd) 



•Excludes routine methodology OR covers only general projects which preclude indexing at the specific level. 
"Oriented significantly to above subject 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



ART 

ARTERIOVENOUS ANASTOMOSIS NORMAL 

SEE CARDIOVASCULAR SYSTEM, ARTERIOVENOUS 
ANASTOMOSIS NORMAL 

ARTERIOVENOUS SHUNTS ABNORMAL 

SEE CARDIOVASCULAR DISORDERS, ARTERIOVENOUS SHUNTS 
ABNORMAL 

ARTERIOVENOUS SHUNTS SURGICAL 
(GENERAL) 

SEE CARDIOVASCUUR SURGERY, CARDIOVASCUUR SHUNTS 
ARTERIOVENOUS (GENERAL) 

ARTERITIS 

SEE CARDIOVASCULAR DISORDERS, ARTERITIS 
ARTHRITIS 

SEE SKELETAL DISORDERS, ARTHRITIS 
ARTHRITIS, RHEUMATOID 

SEE SKELETAL DISORDERS, ARTHRITIS. RHEUMATOID 
ARTHRITIS AND METABOLIC DISEASES 
PROGRAM PROJECT COMMITTEE 
R01HL19082-01 Hypoxia-induced relaxation of vascular 
smooth muscle 

ARTHROPOD BITES, STINGS, VENOMS 

SEE TOXICOLOGY, ANIMAL POISONS, ARTHROPOD 
ARTHROPOD-BORNE VIRUSES (GENERAL) 

SEE VIRUSES, ARBOVIRUSES (GENERAL) 
ARTHROPODS, CRUSTACEANS* 

POlHL-0789615 0060 Environmental biomedical research 
program - Effect of pressure on development of marine 
crustacean larvae 

ARTHROPODS, INSECTS, DIPTERA, CULICIDS, 
MOSQUITOES* 

POlHL-0821415 0023 Chemical and biological properties 
of lipids - Lipids in microorganisms and cell cultures 
(hamsters, mosquitoes) 

ARTIFICIAL BLOOD 

SEE BLOOD SUBSTITUTES 
ARTIFICIAL INTELLIGENCE 

SEE COMPUTER, ARTIFICIAL INTELLIGENCE, PATTERN 
RECOGNITION AND CONTROL SYSTEMS 

ARTIFICIAL KIDNEY 

SEE KIDNEY PROSTHESIS, ARTIFICIAL KIDNEY 
ARTIFICIAL LUNG 

SEE RESPIRATORY SYSTEM PROSTHESIS, PROSTHETIC LUNG 
ARTIFICIAL LUNG, MECHANICAL 

SEE RESPIRATORY ASSIST AND OXYGEN ADMINISTRATION 
RESPIRATORS 

ARTIFICIAL RESPIRATION 

SEE RESPIRATORY ASSIST AND OXYGEN ADMINISTRATION, 
ARTIFICIAL RESPIRATION 

ARTIFICIAL TISSUES 

SEE PROSTHETIC ORGANS AND TISSUES 
ARYL AMINO ACIDS 

SEE CYCLIC AMINO ACIDS 
ARYL HYDROCARBON HYDROXYLASE 

SEE OXYGENASES, HYDROXYLASES, ARYL HYDROCARBON 
HYDROXYLASE 

ASBESTOS 

SEE SILICATES, ASBESTOS 
ASCARIS 

SEE HELMINTHS, NEMATODES, ASCARIS 
ASCHOFF BODIES 

SEE HEART DISORDERS, MYOCARDITIS 
ASCITES 

SEE BODY CAVITY DISORDERS, PERITONEAL EFFUSIONS, 
ASCITES 

ASCITES TUMORS 

SEE NEOPLASMS, ASCITES TUMORS 
ASCORBIC ACID, ASCORBATE 

SEE VITAMIN C 

ASCORBIC ACID DEFICIENCY 

SEE NUTRITIONAL ABNORMALITIES, HYPOVITAMINOSIS C 
ASPARAGINE 

SEE DICARBOXYLIC AMINO ACIDS, ASPARAGINE 
ASPARTASE 

SEE AMMONIALYASES, ASPARTASE 
ASPARTATE TRANSAMINASE 

SEE AMINOTRANSFERASES, ASPARTATE TRANSAMINASE 
ASPARTATE TRANSCARBAMYLASE 

SEE TRANSCARBAMYUSES, ASPARTATE TRANSCARBAMYLASE 
ASPARTIC ACID 

SEE DICARBOXYLIC AMINO ACIDS, ASPARTIC ACID 



IS 

ASPERGILLOSIS 

SEE MYCOSES, ASPERGILLOSIS 
ASPHYXIA, ACCIDENTAL 

SEE INJURIES, ACCIDENTS, SUFFOCATION 
ASPIRATION PNEUMONIA 

SEE RESPIRATORY DISORDERS, PNEUMONIA ASPIRATION 
ASPIRIN 

SEE PHENYLCARBOXYUTES, SALICYLATES, ACETYL- 
ASSAY 

SEE BIOASSAY* 
ASSISTED CIRCULATION 

SEE CARDIOVASCULAR SURGERY. CIRCULATORY ASSIST 
ASSOCIATIONS, HEALTH AND SCIENTIFIC 

SEE HEALTH AND SCIENTIFIC ORGANIZATIONS 

ASTHAAA 

SEE HYPERSENSITIVITY, RESPIRATORY HYPERSENSITIVITY 
ASTHMA 

ASYMMETRIC SEPTAL HYPERTROPHY 

SEE CONGENITAL ABNORMALITIES, HEART DEFECTS 
ASYMMETRIC SEPTAL HYPERTROPHY 

ATARAXIC DRUGS 

SEE PSYCHOPHARMACOLOGICAL AGENTS, TRANQUILIZERS 
ATELECTASIS 

SEE RESPIRATORY DISORDERS, ATELECTASIS 
ATELES 

SEE MAMMALS, PRIMATES, MONKEYS AND APES 

(ANTHROPOIDS, NON-HUMAN), NEW WORLD MONKEYS 
(PLATYRHINES)* 

ATHEROSCLEROSIS 

SEE CARDIOVASCULAR DISORDERS, ARTERIOSCLEROSIS 
ATHEROSCLEROSIS 

ATLASES 

SEE PUBLICATIONS, ATLASES 
ATMOSPHERE 

SEE ENVIRONMENT, ATMOSPHERE (WEATHER) 
ATMOSPHERIC PRESSURE 

SEE ENVIRONMENT, ATMOSPHERIC PRESSURE 
ATOMIC ABSORPTION SPECTROMETRY 

SEE CHEMISTRY, ANALYTICAL METHODS, SPECTROMETRY 
ATOMIC ABSORPTION* 

ATOMIC ORBITALS 

SEE ELECTRONIC SPECTRA, ATOMIC ORBITALS 
ATOPY 

SEE HYPERSENSITIVITY, ATOPY 
ATP 

SEE PURINE NUCLEOTIDES, ADENINE NUCLEOTIDES, ATP 
ATP:AMP PHOSPHOTRANSFERASE 

SEE PHOSPHOTRANSFERASES, ATP:AMP 
PHOSPHOTRANSFERASE 

ATPASE 

SEE PHOSPHATASES. ADENOSINE TRIPHOSPHATASE 
ATP:CREATINE PHOSPHOTRANSFERASE 

SEE PHOSPHOTRANSFERASES. ATP:CREATINE 
PHOSPHOTRANSFERASE 

ATP:DIGLYCERIDE PHOSPHOTRANSFERASE 

SEE PHOSPHOTRANSFERASES, ATP;OIGLYCERIDE 
PHOSPHOTRANSFERASE 

ATP:D-FRUCTOSE-6-PHOSPHATE 1- 
PHOSPHOTRANSFERASE 

SEE PHOSPHOTRANSFERASES. ATP:D-FRUCT0SE-6-PH0SPHATE 
1-PHOSPHOTRANSFERASE 

ATP:D-3-PHOSPHOGLYCERATE 1- 
PHOSPH OTRANSFERASE 

SEE PHOSPHOTRANSFERASES. ATP:D-3-PH0SPH0GLYCERATE 
1-PHOSPHOTRANSFERASE 

ATP PHOSPHOHYDROLASE 

SEE PHOSPHATASES. ADENOSINE TRIPHOSPHATASE 
ATP:PHOSPHORYLASE PHOSPHOTRANSFERASE 

SEE PHOSPHOTRANSFERASES. ATP:PHOSPHORYUSE 
PHOSPHOTRANSFERASE 

ATP:PROTEIN PHOSPHOTRANSFERASE 

SEE PHOSPHOTRANSFERASES. ATPiPROTEIN 
PHOSPHOTRANSFERASE 

ATP:THYMIDINE 5-PHOSPHOTRANSFERASE 

SEE PHOSPHOTRANSFERASES, ATPJHYMIDINE 5- 
PHOSPHOTRANSFERASE 

ATRIA 

SEE HEART, ATRIA 
ATRIAL FIBRILLATION 

SEE HEART DISORDERS, ARRHYTHMIA, ATRIAL FIBRILLATION 



•Ficludes routine methodology OR covers only general projects which preclude indexing at the specific level 
'^•■jn?,' 'p, nif icantly to above subject. 



M Grant has subprojects describing specific research aspects 
See Appendix for invettlgator's name end grant number. 



AUT 
ATRIOVENTRICULAR BLOCK 

SEE HEART DISORDERS, ARRHYTHMIA. HEART BLOCK 
ATRIOVENTRICUUR 

ATRIOVENTRICULAR NODE 

SEE HEART. CONDUCTION SYSTEM. ATRIOVENTRICULAR NODE 
ATRIUM 

SEE HEART. ATRIA 
ATROPINE 

SEE TROPANES. ATROPINE 
ATROPINESTERASE 

SEE CARBOXYLIC ESTER HYOROUSES. CARBOXYLESTERASE 
ATTENTION 

SEE PSYCHIC ACTIVrfY LEVEL. AHENTION 
ATTITUDE TO HEALTH AND HEALTH PROBLEMS 

SEE PSYCHOLOGY, AHITUDE TO HEALTH AND HEALTH 
PROBLEMS 

ATTITUDES 

SEE PSYCHOLOGY, ATTITUDES (AND REUTEO) 
ATTITUDES OF PATIENT CARE PERSONNEL 

SEE HEALTH CARE SERVICES, PATIENT CARE PERSONNEL 
ATTITUDES 

ATYPICAL PNEUMONIA (PPLO) 

SEE RESPIRATORY DISORDERS, PNEUMONIA MYCOPUSMAL 
(PPLO) 

AUDIOMETRY 

SEE EAR DISORDERS DIAGNOSIS, HEARING TESTS 
AUDIOMETRY* 

AUDIOVISUAL AIDS 

SEE EDUCATION, AUDIOVISUAL AND OTHER TRAINING AIDS 
AUDITORY CORTEX 

SEE BRAIN, AUDITORY CORTEX 
AUDITORY THRESHOLDS 

SEE EAR, HEARING, AUDITORY THRESHOLD 
AURICLES, HEART 

SEE HEART, ATRIA 

AUSTRALIAN ANTIGEN (AUA) 

SEE IMMUNOLOGY, ANTIGENS VIRAL. HEPATITIS B ANTIGEN 
(HBAG) 

AUTOANTIBODIES 

SEE IMMUNOPATHOLOGY, AUTOANTIBODIES 
AUTOANTIGENS 

SEE IMMUNOPATHOLOGY. AUTOANTIGENS 
AUTOFLUOROSCOPY 

SEE RADIOGRAPHY, FLUOROSCOPY. AUTOFLUOROSCOPY* 
AUTOGENIC CONDITIONING (TRAINING) 

SEE PSYCHOLOGY. CONDITIONING. AUTOGENIC AND INTERNAL 
CONTROL 

AUTOIAAMUNE DISORDERS 

SEE IMMUNOPATHOLOGY. AUTOIMMUNE DISORDERS 
AUTOIMMUNE HEMOLYTIC ANEMIA 

SEE BLOOD AND RE DISORDERS. ANEMIA HEMOLYTIC 
AUTOIMMUNE 

AUTOMATED ANALYTICAL PROCESSING AND 
CONTROL SYSTEMS 

SEE BIOMEDICAL SYSTEMS AUTOMATED 
AUTOMATED BIOMEDICAL FACILITIES 

SEE BIOMEDICAL SYSTEMS AUTOMATED 
AUTOAAATED HEALTH RECORDS (SYSTEMS) 

SEE HEALTH RECORDS (SYSTEMS) AUTOMATED 
AUTOMATIC DATA PROCESSING 

SEE INFORMATION AND COMMUNICATION. AUTOMATIC DATA 
PROCESSING 

AUTONOMIC AGENTS 

SEE NEUROPHARMACOLOGICAL AGENTS. AUTONOMIC AGENTS 
AUTONOMIC CONDITIONING 

SEE PSYCHOLOGY. CONDITIONING. AUTOGENIC AND INTERNAL 
CONTROL 

AUTONOMIC GANGLIA 

SEE NERVOUS SYSTEM AUTONOMIC. AUTONOMIC GANGLIA 

AUTONOMIC NERVOUS DYSFUNCTION 
FAMILIAL 

SEE CONGENITAL ABNORMALITIES. NEUROLOGICAL 
DYSAUTONOMY FAMILIAL 

AUTONOMIC NERVOUS SYSTEM 

SEE NERVOUS SYSTEM AUTONOMIC 

AUTONOMIC NERVOUS SYSTEM DISORDERS 

SEE NERVOUS DISORDERS AUTONOMIC (GENERAL) 
AUTONOMIC REFLEXES 

SEE NERVOUS SYSTEM AUTONOMIC, AUTONOMIC REFLEXES 

(contd) 



AUT 



1 ') 



AUTONOMY, EMOTIONAL 

Sa PSYCHOIOCY, [MOIIONAl Dll'INOl NCY INOl PI NOt NCY 

AUTO-OXIDATION 

SF( nXIDAIIONREDUCIION. AllIO OXinAIIQN 

AUTOPHAOY 

St I cm OFSTRUCIION. AUIOPHACY 

AUTOPROTHROMBIN I 

Sri BIOOO COAGUIAIION. FACIOR VII 

AUTOPROTHROMBIN II 

Sff BLOOO COAGUIAIION. FACIOR IX 

AUTOPROTHROMBIN III 

SFF BLOOD COAGUIAIION. FACIOR X 

AUTORADIOGRAPHY 

SEE RADIOAUIOGRAPHY* 

AUTOSENSITIZATION 

SEE IMMUNOPAIHOLOGY. AUTOIMMUNE DISORDERS 

AUTOSOMAL RECESSIVE CONDITIONS 

SEE GENETIC DISORDERS. AUTOSOMAL RECESSIVE 
CONDITIONS 

AUTOTRANSFUSION 

SEE BLOOO TRANSFUSION, AUTOTRANSFUSION 

AUTOTRANSPLANTATION 

SEE TISSUE COMPATIBILITY TRANSPLANT. TRANSPLANTATION 
AUTOLOGOUS 

AUXILIARY HEALTH (CARE) PERSONNEL 

SEE HEALTH SCIENCES PROFESSIONS. HEALTH (CARE) 
PERSONNEL ALLIED 

AUXIUARY HEART PROSTHETIC 

SEE HEART PROSTHESIS. AUXILIARY 
AUXILIARY MENTAL HEALTH PERSONNEL 

SEE MENTAL HEALTH PERSONNEL ADJUNCT 
AUXILIARY VENTRICLE, BALLOON PUMP AORTIC 

SEE HEART PROSTHESIS. AUXILIARY, AORTIC BALLOON 
PUMPING 

A-V NODE 

SEE HEART. CONDUCTION SYSTEM. ATRIOVENTRICULAR NODE 
AVAILABILITY AND DISTRIBUTION OF HEALTH 
CARE SERVICES AND RESOURCES 

SEE HEALTHCARE (SERVICESXRESOURCES) UTILIZATION. 
AVAILABILITY AND DISTRIBUTION OF SERVICES AND 
RESOURCES 

AVIAN NEUROLYMPHOMATOSIS 

SEE NERVOUS DISORDERS CENTRAL, MAREK'S DISEASE 

AVIATION MEDICINE 

SEE ENVIRONMENT. EXTRATERRESTRIAL, SUPRATERRESTRIAL 

AVOIDANCE CONDITIONING 

SEE PSYCHOLOGY, CONDITIONING, AVOIDANCE 

AXONS 

SEE NERVOUS SYSTEM. NEURONS. AXONS 

AXOPLASMIC FLOW 

SEE NERVOUS SYSTEM. NEURONS, AXOPLASMIC FLOVK 

1 0-AZAANTHRACENE 

SEE ACRIDINES 
1 -AZABICYCLO(2.3.2)OCTANES 

SEE QUINUCLIDINES 

AZACYTIDINE 

SEE TRIAZINE NUCLEOSIDES, AZACYTIDINE 

AZATHIOPRINE 

SEE THIOPURINES, 6-MERCAPTOPURINE, AZATHIOPRINE 

AZEPINES, DESIPRAMINE 

ROlHL-15758-06 Catecholamine release in the heart 

(dogs) 
ROlHL-1643604 Role of calcium and thyroxine in heart 

function (rats) 

AZEPINES, DIAZEPAM 

POlHL-12738-10 0042 Physiologic pharmacology and its 

clinical applications - Centrogenic cardiac arrhythmias 

(cats) 
POlHL-14388-07 0159 Regulation of the circulation in 

pathological states - Early drug and diet Interventions and 

blood pressure development (rats) 
R0IHL1795804 Circulatory effects of operant 

cardiovascular control (baboons) 
POlHL-18576-03 0007 Thrombosis research program 

project - Relationships between coagulability and 

thrombosis (human, animals) 

AZEPINES, DIAZEPINES 

P60HL1 7269-04 0016 National heart and blood vessel 
research and demonstration center - New analytical 
methodology for atherosclerosis studies 



AZEPINES, DIAZEPINES, CHLORDIAZEPOXIDE 

POIIII I2/J8 10 004? Phytiologic phtrmacolony ond \\\ 

clinicil applications Cfntro|tnic cardiac arihythmiat 
(cats) 

AZEPINES, DIAZEPINES, FLURAZEPAM 

PUIIII I49HSU/ UOO'J AdiipUlioii lu hypoiia Inlluencc 

of chemosensitivity on control ul brc;ithin|i duiing sleep 
(human, dogs) 

AZEPINES, IMIPRAMINE 

R?3Hl I9S73 0I Studies on pulmondiy serotonin (mice) 
ROIHL ?0622 0? Pulmonary uptake and accumulation of 
diugs (rabbits, rats) 

AZETIDINE 

ROIHL 1913603 Mucopolysacchtrid* metabolism in 
cardiac anomalies (rats) 

AZIDES 

ROIHL 12524 10 Reaction ol hemoglobin with ligsnds and 

antibodies (human, carp) 
ROIHL 16860 OS Mossbauer studies of respiratory 

hemoproteins 

AZO (AZINO) COMPOUNDS 

SEE ALSO AZIDES 
ROIHL 13412 17 Synthetic oxygen carriers 

AZO COMPOUNDS, HYDRAZINES, ISONIAZID 

POIHL 12738 10 0001 Physiologic pharmacology and its 

clinical applications Clinical pharmacology of cardioactive 
drugs (human) 

AZO COMPOUNDS, HYDRAZINES, PHENELZINE 

POIHL'12738 10 0001 Physiologic pharmacology and its 
clinical applications Clinical pharmacology of cardioactive 
drugs (human) 

AZO COMPOUNDS, HYDRAZINES, 
PHENYLHYDRAZINES 

ROIHL 19532 01 Oxygen toxicity in the red cell (human) 

AZO COMPOUNDS, HYDRAZINOPHTHALAZINE 

*• POlHL-06312 17 0016 Surgical cardiology ■ Effect of 
hydialazine on inlarct size following coronary occlusion 
(human) 
POlHL-06835-17 0037 Cardiovascular disease - Cardiac 

hypertrophy in spontaneously hypertensive rat 
P01HL06835-17 0053 Cardiovascular disease ■ 

Vasodilating drugs (human) 
P01HL06835'17 0057 Cardiovascular disease - Studies 
on cardiac hypertrophy 

Physiologic pharmacology and its 
Clinical pharmacology of cardioactive 



Physiologic pharmacology and its 
Cardiovascular pharmacology (dogs) 

Regulation of the circulation in 
Kallikrein-kinin system in hypertension 



POIHL 12738 10 0001 

clinical applications 

drugs (human) 
POlHL-12738-10 0111 

clinical applications 
P01HL1438807 0223 

pathological states 

(rats) 
ROlHL'15047-06 Digital computer analysis of the 

electrocardiogram (human) 
ROlHL-1775403 Pathogenesis and prevention of 

hypertension sequelae (rats) 
ROlHL-18579-03 Vasoactive hormones and blood pressure 

regulation (dogs. rats, rabbits) 
P50HL19362-02 0010 A/S SCOR -Atherosclerosis in 

nonhuman primates - Antihypertensive therapy - 

Atherogenesis in experimental hypertension (baboon) 
ROlHL-1966803 Biochemistry of lung connective tissue 

(rats) 
POlHL-20552-02 0002 The development and regression of 

cardiac hypertrophy - Effect of treatment on the 

hypertrophied left ventricle (rats) 
ROlHL-227 18-01 Cardiovascular drug interactions- 
Metabolism models (dogs) 

AZO DYES 

SEE AZO (AZINO) COMPOUNDS 

AZOPROTEINS 

ROlHL-13399-16 Heme protein structure and function 
(human, horse, plants, bacteria) 

BABOONS 

SEE MAMMALS. PRIMATES, MONKEYS AND APES 

(ANTHROPOIDS, NON-HUMAN), OLD WORLD MONKEYS 
(CATARRHINES)* 

BACILLUS CALMETTE-GUERIN 

SEE BACTERIA, ACTINOMYCETALES, BACILLUS CALMETTE- 
GUERIN* 

BACILLUS PILIFORMIS 

SEE BACTERIA, GRAM-NEGATIVE* 
BACITRACIN 

SEE ANTIBIOTICS, BACITRACIN 
BACTEREMIA 

SEE BLOOD TOXICOLOGY, BACTEREMIA-SEPTICEMIA 
BACTERIA, ACID-FAST BACTERIA* 

R01HL-07502-13 Phytochemistry of the genus thalictrum 
(dogs, plants) 



BACTERIA, ACTINOMYCETALES, BACILLUS 
CALMETTE-GUERIN* 

KUIIII 2II2UU2 Mtmbiana dynamics in alveolii 

macrophages (rabbits) 
ROIIII 7230I 01 Immunogenetics of chionic pulmonary 

inflarnmalion (micfl) 

BACTERIA, ACTINOMYCETALES, 

MYCOBACTERIUM TUBERCULOSIS* 

Sf( Also BACIIRIAI DIM AM ',, A(,IIN0MY(,1 lAllS 
INFECTIONS, lUBFRCUIOSI'i 
•• ROIHl 710950? Fn/ymrs o( M tuberculosis and 
obstructive lung disease (human, rodent',) 

BACTERIA. ACTINOMYCETALES, THERMOPHILIC 
ACTINOMYCETES* 

PbOHL 15389 07 001 1 Pulmonary SCOR HypaiMniitivity 

pneumonitis Animal model Hypersensitivity pneumonitis 

in rabbits 
** P50HL 15389 0/ 0015 Pulmonary SCOR Hypersensitivity 

pneumonitis Fractionation and characterization of 

thermophilic Actinomycete antigens 
P50HL 15389 07 0019 Pulmonary SCOR Hypersensitivity 

pneumonitis Microbiology core (human, animal) 

BACTERIA, ENTERIC (GENERAL)* 

SEE ALSO BACTERIA. PSEUDOMONADALES. PSEUDOMONAS 

AERUGINOSA* 
SEE ALSO BACTERIA, STREPTOCOCCACEAE, STREPTOCOCCUS, 
ENTEROCOCCUS GROUP* 
** ROIHL 10894 12 Intestinal bacteria and steroid 
metabolism (human, guinea pigs, rabbits, rats) 
ROlHL-17818 05 Metabolism ol cholesterol and cholesterol 
in man (also rats, monkeys) 
** P50HL 19362-02 0009 A/S SCOR Atherosclerosis in 

nonhuman primates Cholesterol metabolism and 
intestinal microflora (baboon) 

BACTERIA, ENTERIC, RUMEN BACTERIA* 

** R01HL13645-11 Tryptophaninduced pulmonary 
emphysema (cattle, goats, rabbits) 

BACTERIA, ENTEROBACTERIACEAE, PROTEUS* 

ROlHL-22029-02 Bronchopulmonary resistance to bacterial 
infection (mice) 

BACTERIA, ENTEROBACTERIACEAE, SERRATIA 
MARCESCENS* 

** POlHL-16769-05 0004 Pathobiologic and host defense 
reactions in the lung - Pathogenesis of Pseudomonas and 
Serratia pneumonias (rabbits) 

BACTERIA, GRAM-NEGATIVE* 

SEE ALSO BACTERIA. HALOBACTERIACEAE* 
ROlHL-07502-13 Phytochemistry of the genus thalictrum 
(dogs, plants) 

BACTERIA, HALOBACTERIACEAE* 

** POlHL-06285-18 0211 Cardiovascular-respiratory 
physiology and biochemistry - Purple membrane of 
Halobacteria 

•* POlHL-06285-18 0213 Cardiovascular-respiratory 

physiology and biochemistry - Membrane structure and 
function -Gas vacuole membrane (Halobacterium) 

BACTERIA, MICROCOCCACEAE, 
STAPHYLOCOCCUS* 

SEE ALSO BACTERIAL DISEASES, STAPHYLOCOCCAL 
INFECTIONS 
R01HL-I6646-05 Pathobiology of thromboembolic disorders 

(human) 
POlHL-16769-05 0004 Pathobiologic and host defense 
reactions in the lung - Pathogenesis of Pseudomonas and 
Serratia pneumonias (rabbits) 

BACTERIA, MICROCOCCACEAE, 
STAPHYLOCOCCUS AUREUS* 

ROlHL-203 14-02 Host defense against S pheumoniae in 

sickle cell disease (human) 
ROlHL-22029-02 Bronchopulmonary resistance to bacterial 

infection (mice) 

BACTERIA, MICROCOCCACEAE, 
STAPHYLOCOCCUS EPIDERMIDIS* 

ROlHL-17751-03 Experimental endocarditis (rabbits) 

BACTERIA, MYCOPLASMATALES, MYCOPLASMA* 

ROlHL-19741-03 Murine CRD -A model of chronic 
pulmonaiy inflammation (mice, rats) 

BACTERIA, MYCOPLASMATALES, MYCOPLASMA 
PNEUMONIAE* 

SEE ALSO RESPIRATORY DISORDERS. PNEUMONIA 
MYCOPLASMAL (PPLO) 
P50HL-14136-07 0003 Pulmonary SCOR-Airways 

obstructive diseases - Acute pediatric respiratory disease 
and COLD 

BACTERIA, NEISSERIACEAE, NEISSERIA 
MENINGITIDIS* 

P01HL-06350-17 0019 Hemostasis research program 

project - Microcirculation (human, rats, rabbits) 

(contd) 



*Exclude$ routine methodology OR covers only general projects which preclude indexing at the specific level. 
**Onented significantly to above subject. 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



BAC 

BACTERIA, PSEUDOMONADALES, 
PSEUDOMONAS* 

" ROlHL-13885-08 0007 Cystic fibrosis and pulmonary 
disease ■ Alveolar macrophage defense mectianism 
(human, rabbits) 

BACTERIA, PSEUDOMONADALES, 
PSEUDOMONAS AERUGINOSA* 

POlHL-06314-17 0046 Immunologic mechanisms in 

cardiovascular disease - Mediators of immune injury 

(human, mice) 
POlHL-06370-17 0013 Cardiopulmonary and renal 

pathology research center ■ (Morphologic analysis of 

vascular prosthesis (human, dogs) 
ROIHL 13885-08 0006 Cystic fibrosis and pulmonary 

disease - Cell mediated immunity and Pseudomonas 

infections in cystic fibrosis (human) 
R01HL13885-08 0007 Cystic fibrosis and pulmonary 

disease - Alveolar macrophage defense mechanism 

(human, rabbits) 
R01HL13885 08 0008 Cystic fibrosis and pulmonary 

disease - Pseudomonas specific activation of alveolar 

macrophages (human, rabbits) 
** POlHL-16769-05 0004 Pathobiologic and host defense 

reactions in the lung - Pathogenesis of Pseudomonas and 

Serratia pneumonias (rabbits) 
POlHL-1676905 0008 Pathobiologic and host defense 

reactions in the lung - Pulmonary immunocytologic defense 

mechanisms against bacteria (human, animals) 
P50HL-1915302 0003 SCOR-Pulmonary edemas-Eltology. 

pathogenesis - Possible inhibitors of mediator release and 

pulmonary vascular response (sheep) 
R23HL-21212-02 Alveolar macrophage function in 

Pseudomonas infection (dgs) 

BACTERIA, STREPTOCOCCACEAE* 

P50HL1421807 0005 Pulmonary SCOR-Nev»born lung 
center ■ Prevention of infection in infants with respiratory 
distress (human) 

BACTERIA, STREPTOCOCCACEAE, 
STREPTOCOCCUS* 

SEE ALSO BACTERIAL DISEASES, STREPTOCOCCAL 
INFECTIONS 
** ROlHL-03919-20 The cell suface of streptococci (rats, 
human) 

BACTERIA, STREPTOCOCCACEAE, 

STREPTOCOCCUS, ENTEROCOCCUS GROUP* 

POlHL-0631417 0059 Immunologic mechanisms in 

cardiovascular disease - Immunogenetic response to 
streptococcal antigens in man 

R01HL17751-03 Experimental endocarditis (rabbits) 

BACTERIA, STREPTOCOCCACEAE, 
STREPTOCOCCUS GROUP A* 

SEE ALSO IMfVIUNOLOGY, ANTIGENS BACTERIAL, 
STREPTOKINASE 
ROlHL-01803-23 0001 Arteriosclerosis, glomerulonephritis, 
rheumatic fever • Post-streptococcal glomerulonephritis 
(rabbit) 
POlHL-0631417 0060 Immunologic mechanisms in 
cardiovascular disease ■ Strept antigens and infections in 
cardiovascular complications (human, animals) 
** R01HH9234-03 Streptococci and heart ■Cell-mediated 
;ross-reaction (mice) 
ROlHL-2053309 Pathogenesis of rheumatic fever (human, 
rabbits) 

BACTERIA, STREPTOCOCCACEAE, 
STREPTOCOCCUS GROUP B* 

POlHL-06314-17 0060 Immunologic mechanisms in 

cardiovascular disease - Strept antigens and infections in 
cardiovascular complications (human, animals) 

BACTERIA, STREPTOCOCCACEAE, 
STREPTOCOCCUS GROUP C* 

POlHL-06314-17 0059 Immunologic mechanisms in 

cardiovascular disease • Immunogenetic response to 
streptococcal antigens in man 

BACTERIA, STREPTOCOCCACEAE, 
STREPTOCOCCUS PNEUMONIAE* 

SEE ALSO VACCINES, BACTERIAL, PNEUMOCOCCAL VACCINE 
POlHL-06350-17 0019 Hemostasis research program 

project - Microcirculation (human, rats, rabbits) 
P60HL-15169-05 0009 Support for center for sickle cell 

disease - Infections in sickle cell anemia (human) 
ROlHL-20314-02 Host defense against S pheumoniae in 

sickle cell disease (human) 
ROlHL-22029-02 Bronchopulmonary resistance to bacterial 

infection (mice) 

BACTERIAL ANTIBODIES 

SEE IMMUNOLOGY. ANTIBODIES BACTERIAL 
BACTERIAL ANTIGENS 

SEE IMMUNOLOGY. ANTIGENS BACTERIAL 
BACTERIAL ANTITOXINS 

SEE IMMUNOLOGY. ANTITOXINS 

BACTERIAL DISEASES 

SEE ALSO BLOOD TOXICOLOGY, BACTEREMIA-SEPTICEMIA 



20 

SEE ALSO COMMUNICABLE DISEASE CONTROL AGENTS 

ANTIBACTERIAL 
SEE ALSO IMMUNOLOGY, ANTIBODIES BACTERIAL 
SEE ALSO IMMUNOLOGY. ANTIGENS BACTERIAL 
SEE ALSO NERVOUS DISORDERS CENTRAL, MENINGITIS 

BACTERIAL 
SEE ALSO RESPIRATORY DISORDERS, PNEUMONIA BACTERIAL 
M POlHL-06314-17 Immunologic mechanisms in 
cardiovascular disease 
POlHL-063 14-17 0046 Immunologic mechanisms in 

cardiovascular disease Mediators of immune injury 
(human, mice) 
** P50HL142 18-07 0005 Pulmonary SCOR-Nev»born lung 

center - Prevention of infection in infants with respiratory 
distress (human) 
** P60HL-151 69-05 0009 Support for center for sickle cell 

disease - Infections in sickle cell anemia (human) 
P60HL 15996-06 0003 Cincinnati comprehensive sickle 

cell center - Prophylactic penicillin in treatment of sickle 
cell anemia (human) 
P60HL-15996-06 0005 Cincinnati comprehensive sickle 

cell renter - Factors precipitating crises (human) 
ROlHL-19774-03 Pathogenesis of chronic lung disease 

(rats, mice, bacteria) 
ROlHL-22029-02 Bronchopulmonary resistance to bacterial 
infection (mice) 

BACTERIAL DISEASES, ACTINOMYCETALES 
INFECTIONS, TUBERCULOSIS 

SEE ALSO BACTERIA, ACTINOMYCETALES, MYCOBACTERIUM 
TUBERCULOSIS* 
P50HL141 53-07 0004 Johns Hopkins Lung Center 

Chronic diseases of airways • Macrophage enzymes in lung 
injury, inflammation and repair (rabbit) 

BACTERIAL DISEASES, CYTOPATHOGENIC 
EFFECT BACTERIAL 

ROlHL-01803-23 0001 Arteriosclerosis, glomerulonephritis, 

rheumatic fever - Poststreptococcal glomerulonephritis 

(rabbit) 
R01HL19741-03 Murine CRD-A model of chronic 

pulmonary inflammation (mice, rats) 
ROlHL-20063-03 Pathogenesis of pulmonary mycoplasma 

infections (guinea pigs, mice) 
ROlHL-2017002 Pulmonary infection in splenectomized 

animals (mice) 
** ROlHL-20963-01 Experimental lung abscess (rabbits) 
ROlHL-2252001 Pulmonary vascular response to group B 

Streptococci (human, mammals) 

BACTERIAL DISEASES, STAPHYLOCOCCAL 
INFECTIONS 

SEE ALSO BACTERIA. MICROCOCCACEAE, STAPHYLOCOCCUS* 
SEE ALSO SKELETAL DISORDERS, OSTEOMYELITIS 
** ROlHL-221 10-02 Healing complications in vascular 
grafting (dogs) 

BACTERIAL DISEASES, STREPTOCOCCAL 
INFECTIONS 

SEE ALSO BACTERIA, STREPTOCOCCACEAE, 
STREPTOCOCCUS* 
ROlHL-01803-23 0001 Arteriosclerosis, glomerulonephritis, 
rheumatic fever - Poststreptococcal glomerulonephritis 
(rabbit) 
ROlHL-01803-23 0018 Arteriosclerosis, glomerulonephritis, 
rheumatic fever ■ Fetal immunization in pathogenesis of 
glomerulonephritis in adult (rabbit) 
** ROlHL-01803-23 0019 Arteriosclerosis, glomerulonephritis, 
rheumatic fever - Pathogenesis of rheumatic heart disease 
(rabbit) 

Immunologic mechanisms in 
■ Antigens in cardiovascular disease 



POlHL-063 14-17 0057 
cardiovascular disease 
(human) 

POlHL-063 14-17 0059 
cardiovascular disease 



Immunologic mechanisms in 
Immunogenetic response to 

streptococcal antigens in man 
** POlHL-06314-17 0060 Immunologic mechanisms in 

cardiovascular disease ■ Strept antigens and infections in 

cardiovascular complications (human, animals) 
P60HL-15160-07 0014 Center for sickle cell disease - 

Replacement therapy of opsonin deficiency in sickle cell 

anemia (children) 
** P60HL-15162-07 0021 Comprehensive sickle cell center ■ 

Pneumococcal vaccine in sickle cell disease (children) 
** ROlHL-201 70-02 Pulmonary infection in splenectomized 

animals (mice) 
*♦ P60HL-20985-01 0002 Northern California sickle cell 

center - Immunization with polyvalent pneumococcal 

polysaccharide vaccine (human) 
** ROlHL-22520-01 Pulmonary vascular response to group B 

Streptococci (human, mammals) 
P60HL-23282-01 0002 Comprehensive hospital/community 

sickle cell center - Clinical evaluation of alternate 

pathaway of compliment activation 

BACTERIAL DISEASES, STREPTOCOCCAL 
INFECTIONS, RHEUMATIC FEVER 

SEE ALSO HEART DISORDERS, RHEUMATIC HEART DISEASE 
ROlHL-039 19-20 The cell suface of streptococci (rats, 
human) 
** POlHL-063 14-17 0057 Immunologic mechanisms in 

cardiovascular disease ■ Antigens in cardiovascular disease 
(human) 



•Excludes routine methodology OR covers only general projects which preclude indexing at the specific level. 
"Oriented significantly to above subject. 



M Grant has subprajects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



BAR 

POlHL-063 14- 17 0060 Immunologic mechanisms in 

cardiovascular disease ■ Strept antigens and infections in 
cardiovascular complications (human, animals) 

ROlHL-19234-03 Streptococci and heart -Cell-mediated 
cross-reaction (mice) 

ROlHL-1930703 Problems in prevention of rheumatic 
heart disease (human) 

ROlHL-20533-09 Pathogenesis of rheumatic fever (human, 
rabbits) 

BACTERIAL ENDOCARDITIS 

SEE HEART DISORDERS, ENDOCARDITIS BACTERIAL 
BACTERIAL MENINGITIS 

SEE NERVOUS DISORDERS CENTRAL, MENINGITIS BACTERIAL 
BACTERIAL PERMEASES 

SEE BIOLOGICAL TRANSPORT, TRANSPORT PROTEINS 
PERMEASES 

BACTERIAL PNEUMONIA 

SEE RESPIRATORY DISORDERS, PNEUMONIA BACTERIAL 
BACTERIAL POLYSACCHARIDES 

SEE POLYSACCHARIDES, BACTERIAL (GENERAL) 
BACTERIAL PROTEINS 

SEE PROTEINS, BACTERIAL (GENERAL) 
BACTERIAL TOXINS 

SEE IMMUNOLOGY, ANTIGENS BACTERIAL, BACTERIAL TOXINS 
(GENERAL) 

BACTERIAL VACCINES 

SEE VACCINES, BACTERIAL (GENERAL) 
BACTERICIDAL DEFENSES OF BODY (GENERAL) 

SEE IMMUNITY. BACTERICIDAL DEFENSES (GENERAL) 
BACTERICIDES 

SEE COMMUNICABLE DISEASE CONTROL AGENTS 
ANTIBACTERIAL 

BACTERIOLOGY AND MYCOLOGY STUDY 
SECTION 

ROlHL-17751-03 Experimental endocarditis (rabbits) 
ROlHL-19234-03 Streptococci and heart -Cell-mediated 

cross-reaction (mice) 
ROlHL-19307-03 Problems in prevention of rheumatic 

heart disease (human) 
ROlHL-19760-01 Cellular immune responses of the lung 

(mice, guinea pigs) 
ROlHL-19873-03 Pulmonary responses to inhaled antigen 

(rabbits, guinea pigs) 
ROlHL-20314-02 Host defense against S pheumoniae in 

sickle cell disease (human) 
R23HL-2121202 Alveolar macrophage function In 

Pseudomonas infection (dgs) 
ROlHL-22029-02 Bronchopulmonary resistance to bacterial 

infection (mice) 
ROlHL-22257-01 Leukokinesis enhancing factor and lung 

infections (human, rats) 
R23HL-22823-0I Phagocytic and immune defense 

mechanisms of the lung (mice) 

BACTERIOLYSIS 

R23HL-21 116-02 Mechanisms of membrane and tissue 
damage in lung (dogs, rabbits) 

BACTERIORHODOPSIN 

SEE PIGMENTS. BACTERIAL. BACTERIORHODOPSIN-RETINAL 
BACTERIOTROPINS 

SEE IMMUNOLOGY. ANTIBODIES. OPSONINS 
BALLISTOCARDIOGRAPHY 

SEE HEART DISORDERS DIAGNOSIS, 
BALLISTOCARDIOGRAPHY* 

BALLOON PUMPING, AORTIC 

SEE HEART PROSTHESIS, AUXILIARY, AORTIC BALLOON 
PUMPING 

BANK, TISSUE 

SEE TISSUE RESOURCES, REGISTRIES 
BAPN 

SEE CYANIDES, AMINOALKYL NITRILES, BAPN 
BARBITURATES 

SEE PYRIMIDINES, BARBITURATES 
BARIUM (COMPOUNDS) 

SEE METALS, ALKALINE EARTH METALS. BARIUM 
BAROMETRIC DECOMPRESSION 

SEE ENVIRONMENT. ATMOSPHERIC PRESSURE. 
COMPRESSIONDECOMPRESSION 
BAROPACER (CAROTID) 

SEE HEART PACEMAKERS ELECTRONIC, CAROTID 
STIMULATORS 

BARORECEPTORS 

SEE SENSE ORGANS, PRESSORECEPTORS 

BARRIER MODEL 

SEE BIOLOGICAL TRANSPORT, MEMBRANE MODELS 

(contd) 



BAS 

BARHER'S SYNDROME 

SH MIIAHOlir DISOKniKS INBORN BARnfRS SVNOKOMt 
BASEMENT MEMBRANE 

Sfl MIMHHANl, BASIMINI MIMHH»N1 

BASEMENT MEMBRANE DISEASE OF LUNG AND 
KIDNEY 

SEE DISEASES. SYNDROMES NOI LISIEO ELSEWHERE. 
GOODPASTURE S SYNDROME 

BASES 

SEE ACIDS BASES, BASES (GENEKAl) 

BASES (NUCLEOSIDE, NUCLEOTIDE, NUCLEIC 
ACID) 

SEE NUCIEOBASES 

BASOPHIL LEUKOCYTES 

SEE BIOOD CEllS. LEUKOCYTES. BASOPHILS 

BASSEN-KORNZWEIG SYNDROME 

SEE MEIA80UC DISORDERS INBORN 

HYPOLIPOPROTEINEMIAS fAMILIAL 
ABETALIPOPROTEINEMIA 

BATRACHOTOXIN 

SEE TOXICOLOGY. ANIMAL POISONS. BATRACHOTOXIN 
BCG 

SEE BACTERIA. ACTINOMYCETALES. BACILLUS CALMEHE 
GUERIN* 

BEDDING FOR ANIMAL CARE 

SEE ANIMALS. VETERINARY SCIENCE. ANIMAL CARE 
BEHAVIOR 

SEE PSYCHOLOGY, BEHAVIOR 

BEHAVIOR, ANIMAL 

SEE PSYCHOLOGY. BEHAVIOR ANIMAL 

BEHAVIOR, MATERNAL 

SEE FAMILY. MATERNAL BEHAVIOR 

BEHAVIOR ASSESSMENT-MEASUREMENT 

SEE PSYCHOLOGICAL TESTS. BEHAVIOR ASSESSMENT- 
MEASUREMENT* 

BEHAVIOR CONTROL 

SEE PSYCHOLOGY, BRAIN CONTROL 

BEHAVIOR MODIFICATION (PSYCHOTHERAPY) 

SEE PSYCHOTHERAPY, BEHAVIOR MODIFICATION 

BEHAVIOR PREDICTION 

SEE PSYCHOLOGY, BEHAVIOR PREDICTION 

BEHAVIOR RATING SCALES 

SEE PSYCHOLOGICAL TESTS. BEHAVIOR ASSESSMENT- 
MEASUREMENT* 

BEHAVIOR THERAPY 

SEE PSYCHOTHERAPY. BEHAVIOR MODIFICATION 

BEHAVIORAL GENETICS 

SEE PSYCHOGENETICS-BEHAVIORAL GENETICS 
BEHAVIORAL MEDICINE 

SEE ALSO HEALTH CARE SERVICES. PATIENT CARE 
PERSONNEL AHITUOES 

SEE ALSO HEALTH CARE SERVICES, PATIENT-PROFESSIONAL 
RELATIONS 

SEE ALSO PSYCHOLOGY, ATTITUDE TO HEALTH AND HEALTH 
PROBLEMS 

SEE ALSO PSYCHOPHYSIOLOGIC DISORDERS 
POIHL-10539-12 0023 Pathophysiology of circulation - 

The relaxation response and therapy of disease states 

(human) 
POIHL 10539-12 0031 Pathophysiology of circulation - 

Post myocardial infarction care -Psychological aspects 

(human) 
POIHL-10539-12 0066 Pathophysiology of circulation - 

Usefulness of relaxation response in industrial settings 
P50HL-I4236-05 0013 Prevention of premature 

arteriosclerosis - Patient compliance 
P60HL-15158-07 0009 Comprehensive sickle cell center - 

Counseling and social services 
P60HL-15160-07 0003 Center for sickle cell disease - 

Genetic counseling in hemoglobinopathies-Dimensions, 

effectiveness 
PG0HL-15162-07 0011 Comprehensive sickle cell center - 

Core program- Genetic counseling and diagnostic screening 
P60HL-15999-05 0004 Miami comprehensive sickle cell 

center - Education, screening and counseling 
R25HL-I7056-01 Improving patient compliance through 

nursing action 
P60HL-17269-04 0047 National heart and blood vessel 

research and demonstration center - Evaluation of 

competency-based educational model 
ROlHL-17465-04 Beta-thalassemia screening and genetic 

counseling 
ROIHL-1 7958-04 Circulatory effects of operant 

cardiovascular control (baboons) 
R25HL-18414-03 Hypertension -Family strategies for 

patient adherence 
R25HL-184I8-03 Role of a supporting partner in 

adherence (human) 



il 

R7SHI 18474 03 Blood prtssuce aducilion in an induilrml 

setlinij (human) 
ROIMI l»HUU:i Bchaviuidl Inctic] lor clinical cardiac 

cunliol (human) 
KOI HI 1 8823 02 Physiolo|!ical coirolalos of conditioned 

t)laod pressure (human) 
*• ROIHI l«')(i;03 Objective ov.iluation esily .iflci Ml and 

heart suicery (human) 
*■ ROIHl 19343 03 Behavioral influences on cardiac 

contractility (monkeys) 
ROIHl 19568 03 Hypertension Analysis of dru| and 

behavioral therapies (human) 
ROIHL 19844 02 Behavioral control ot essential 

hypeilpiision (human) 
ROIHl 701/9 02 Epidemiology of sudden cardiac death 

among women 
ROIHl 2091002 The alternative diet for coronary disease 

prevention (human) 
ROIHL 21318 02 Mechanisms of emotions' asthma 

triggering effect (human) 
ROIHL 21323 02 Raynaud's disease and temperature self 

regulation (human) 
ROIHL 21426 02 Learned heart rate control (human) 
ROIHL 21427 02 Behavioral changes in post infarction 

patients 
ROlHL-21532 02 Cardiovascular homeostasis and learning 

(frogs, rats, human) 
** R18HL 2190601 Stanford five city multifactoi risk 

reduction study 
ROIHL 2206501 Intractability, medication, and coping 

styles in asthma (human) 
M R23HL 22345-02 Behavioral cardiovascular compliance 

strategies 
R23HL 22345 02 0001 Behavioral cardiovascular 

compliance strategies Long term modification of dietary 

patterns (human) 
R23HL-22345 02 0002 Behavioral cardiovascular 

compliance strategies Compliance with antihypertensive 

medication regimens (human) 
** ROIHL 2237801 Psyco somatic predictors of CHD in 

adolescence (human) 
** ROIHL 22514 01 Behavior patterns, stress, and 

catecholamines 
** ROlHL-22547 01 Behavioral treatment of Raynaud's 

disease (human) 
** ROIHL 22740 01 Behavior and cardiovascular disease - 

Basic mechanisms (human) 
** R01HL22809 01 Coronary prone behavior and 

cardiovascular reactivity (human) 
ROIHL 22847 01 Test for adherence to diets rich in 

linoleic acid 
** R18HL-22934-01 Behavorial approaches to adolescent 

hypertension 
N01HR-72973-0I Health education and attitudes of family 

toward asthmatic children 
NOIHR-72974 01 Self management systems for asthmatic 

children 

BEHAVIORAL SCIENCES (DEVELOPMENTAL) 
STUDY SECTION 

** ROIHL 18589 03 Psychosocial factors and outcome in 

coronary disease (human) 
** R01HL-20655 02 Autonomic predictors of hypertension in 

children 
** R0IHL-2202I-01 Asthma in families- Behavior analysis of 

family interaction pattern 
** R01HL-22065-0I Intractability, medication, and coping 

styles in asthma (human) 

BENADRYL 

SEE PHENYULKOXYALKYUMINES, DIPHENHYDRAMINE 
BENCE-JONES PROTEINS 

SEE GLOBULINS. MYELOMA GLOBULINS, BENCE-JONES 
PROTEINS 

BENZANTHRACENES 

SEE CYCLICS. CARBOPOLYCYCLICS. BENZANTHRACENES 

BENZ(E)AZUIENES, ACONITINE TYPE 

SEE ALKALOIDS, ACONINE TYPE 

BENZEDRINE 

SEE PHENYLALKYUMINES. AMPHETAMINE 
BENZENE 

R23HL 19573-01 Studies on pulmonary serotonin (mice) 

BENZOATES 

SEE PHENYLCARBOXYLATES, BENZOATES 

1,3-BENZODIOXOLES 

ROIHL 20622-02 Pulmonary uptake and accumulation of 
drugs (rabbits, rats) 

BENZOFURANONES, PHTHALIDES, 
BROMSULPHTHALEIN 

POIHL 08899-14 0061 Tolerance to respiratory gases in 
health and disease Hepatic oxygenation and secretory 
functions (rats, dogs) 

BENZOIC ACID, BENZOATES 

SEE PHENYLCARBOXYUTES. BENZOATES 



•Excludes routine methodology OR covers only general proiects which preclude indexing at the specific level 
•"Oriented significantly to above subject 



M Grant has subproiects describing spec! 
See Appendix for investigator's name and 



BEN 

BENZOPYRANS, XANTHENES. FLUORESCEINS 

KOIHl 1//U2U4 lleilio optical dytt ai piobat ol hiarl 

eicilabilily 

BENZOPYRENES 

,11 (.YClli;', CAHBOPOircrCllCS. B£N/OPYR£NtS 
BENZO(B)PYRIDINE 

Ml OIIINOIINI', 

BENZO(C)PYRIDINE 

Ml OIIINOIINI', I'.OODINOLINtS 

BENZO-ALPHA-PYRONES 

ROIHl 09163 ri Control mechanisms in hemoslaiil 

(human) 
" POIHL 11414 II 0033 Thrombosis and atheroicleiosis 

program Human coumaiin induced prothrombin 
ROIHL 14847 07 Mechanism of action of vitamin K and 

anticoagulants (rats) 
ROIHL 15698 12 factors affecting the action of 

anticoagulants (rats, human) 
POIHL 185/6 03 0003 Thrombosis research program 

project Biocompatible materials 
ROIHL 21476 02 Anticoagulant drug absorption 

interactions (rats) 

BENZO-ALPHA-PYRONES, 
BISHYDROXYCOUMARIN 

POI HL 13738 08 0003 Cardiac assist devices and 

artificial hearts Pathophysiological effects of the artificial 

heart (calves) 
ROIHL 15698 12 Factors affecting the action of 

anticoagulants (lats, human) 
R01HL-2I47602 Anticoagulant drug absorption 

interactions (rats) 

BENZO-ALPHA-PYRONES, WARFARIN 

ROIHL 13754 08 Postoperative thromboembolism in 

surgical patients (human) 
R01HL-15698-I2 Factors affecting the action of 

anticoagulants (rats, human) 
POIHL 18576 03 0007 Thrombosis research program 

project Relationships between coagulability and 

thrombosis (human, animals) 
ROIHL 18738-02 Prevention of postoperative venous 

thrombi (human, cattle) 
** ROIHL 1977202 Role of warfarin metabolism in 

antivitamin K activity (rats) 

BENZOPYRROLE CARBOXYLIC ACIDS, 
INDOMETHACIN 

POlHL-06835 17 0031 Cardiovascular disease Synthesis 

of potent antagonist of pressor action of angiotensin II 

(animals) 
P01HL-I1351 12 0015 Cellular and molecular 

mechanisms of myocardial function - Eftects of hypoxia 

and ischemia on ion exchange and heart function (rabbits) 
ROIHL 11802-10 Cardiovascular surgical research (dogs. 

sheep, swine, cats, monkeys) 
P50HL-14192-08 0003 Specialized center of research in 

hypertension - Prostaglandins as mediators of renin 

secretion (human, dog) 
P50HL I42I4 07 0026 Newborn lung center for hyaline 

membrane disease - Hemodynamic studies of HMD- 

Prostaglandins production and blockers (lambs) 
P01HL-I4388 07 0180 Regulation of the circulation in 

pathological states - Regulation of cerebral blood flow 

(dogs, monkeys) 
POIHL 14388 07 0225 Regulation of the circulation in 

pathological states - Release of renal prostaglandins by 

saluretic-diuretic agents (dogs) 
** P01HL-I4388-07 0230 Regulation of the circulation in 

pathological states Effects of indomethacin in patients 

with carcinoid syndrome 
POIHL 14388-07 0231 Regulation of the circulation in 

pathological states • Mechansim of cutaneous 

vasodilatation in Pagefs disease of bone 
ROIHL-15580-06 Humoral control of pulmonary and 

systemic circulation (animals) 
ROlHL-15681-06 Coronary flow studies of partially 

obstructed vessels (dogs) 
ROIHL 16437-05 Drug treatment of atherosclerosis 

(rabbits, monkeys) 
ROlHL-16489-04 Renal prostaglandins -Synthesis and 

function (human, dogs, rats) 
R0IHL-I6496-04 Prostaglandins and renin experimental 

hypertension (rabbits) 
ROlHL-16760-05 Dynamic control of coronary blood flow 

(dogs) 
R01HL-I758I-03 Patent ductus arteriosus and pulmonary 

hypertension (dogs) 
ROIHL 17759-03 Studies of myocardial reactive hyperemia 

(dogs, human) 
ROIHL 18579-03 Vasoactive hormones and blood pressure 

regulation (dogs, rats, rabbits) 
ROIHL I87I804 Prostaglandin precursors and vascular 

reactivity (dogs) 
POIHL-18827-02 0006 Platelet vessel wall interactions in 

thrombogenesis Platelet immune injury in man 
ROlHL-18845-04 Regulation of renal circulation and salt 

excretion (rats, dogs) 
ROIHL 18932-03 Brain microcirculation observed in vivo 
after trauma (mice) 

(contd) 
tic research aspects, 
grant number. 



BEN 

ROlHL-18979-02 Mechanisms in local regulation of 

coronary flow (rabbits) 
R01HL19202-03 Adenosine, prostaglandins in relation to 

coronary flow (guinea pigs) 
ROlHL-19218-03 Local regulation of coronary flow by 

prostaglandins (rabbits) 
ROlHL-19287-03 The antihypertensive function of the 

renal medulla (human, rats, rabbits) 
ROlHL-20783-02 Airway reactivity-B-adrenoceptors and 

prostaglandins (guinea pigs) 
ROlHL-22087-02 Humoral mediators of pulmonary 

inflammation (guinea pigs) 
R23HL-2230901 Cardiovascular pharmacodynamics in 

immature dogs 
R23HL-22438-01 The etiology of genetic hypertension 

(rats) 
R01HL-22527-0I Prostacyclin-thromboxanes in the 

cardiovascular system (human rabbits) 
ROlHL-2256302 Prostaglandins, the kidney and 

hypertension (rats) 
ROlHL-2257301 Treatment of post surgical 

vasoconstriction (dogs, monkeys, human, rats) 
ROlHL-22783 01 Hemodynamic induction of intimal 

fibromuscular lesion 
ROIHL 22836-01 The spontaneously hypertensive kidney 

(rats) 
R23HL-22882-01 li/lodulation by disease of effect of 

furosemide in man 
ROlHL-23602-01 Physiology of renin, aldosterone and 

prostaglandin (human, rats, dogs) 

BENZOPYRROLES, INDOCYANINE GREEN 

" ROlHL-03181-21 0029 Hemodynamics as applied to 
surgical problems - Indocyanine green clearance for 
estimation of hepatic blood flow (human) 

BENZOPYRROLES, INDOLEAMtNES (GENERAL) 

SEE ALSO BENZOPYRROLES, SEROTONIN 
ROIHL 13315-08 Disposition of vasoactive hormones in 
mammalian lung (rats, rabbits, human) 

BENZOPYRROLES, INDOLES (SEE ALSO 
APPROPRIATE SPECIFICS UNDER 
BENZOPYRROLES) 

SEE ALSO ALKALOIDS. VINBUSTINE 
SEE ALSO ALKALOIDS, VINCA 
ROlHL-1364511 Tryptophan-induced pulmonary 

emphysema (cattle, goats, rabbits) 
R01HL-16471-D5 Cardioactive alloyohimbines and related 

Indole alkaloids 
ROlHL-21540-02 Specific inhibitors of coagulation and 
fibrinolysis (rats, rabbits, dogs) 

BENZOPYRROLES, METHOXYINDOLES 

ROlHL-13645-11 Tryptophan-induced pulmonary 
emphysema (cattle, goats, rabbits) 

BENZOPYRROLES, PHYSOSTIGMINE 

ROlHL-14844-06 Mucous glycoprotein in human respiratory 
epithelium (also wheat) 

BENZOPYRROLES, SEROTONIN 

ROlHL-05883-18 0001 Reflex control of resistance and 
capacitance vessels - Naturally occurring vasoactive 
substances and the vascular neuroeffectors (dog) 
ROlHL-09283-14 Pharmacology of molluscan hearts (also 

rabbits) 
POlHL-10342-13 0019 The integrated function of 
respiration and circulation Cerebral circulation and 
metabolism (dogs) 
ROIHLI 1897-11 Pathogenesis of experimental 

atherosclerosis (rabbits, guinea pigs) 
ROlHL-13315-08 Disposition of vasoactive hormones in 

mammalian lung (rats, rabbits, human) 
ROlHL-13323-08 Intrarenal pressure and renal function 

(human, dogs) 
ROlHL-13466-08 Pulmonary platelets in shock, trauma 

and embolization (dogs, pigs, rats) 
P50HL-14147-08 0018 Specialized center of research in 
thrombosis - Biochemical aspects of platelet function in 
thrombosis and cell growth (human) 
P50HL-14164-07 0044 A/S SCOR-Comparative and 
experimental atherosclerosis - Cell biology-atherosclerosis 
project (pigeons) 
P50HL-I4217-08 0057 Specialized center of research in 
thrombosis - Pharmacology -Platelet biochemistry (human, 
animal) 

Regulation of the circulation in 
• Ionic basis of depolarization (rats. 



POIHL 14388-07 0168 
pathological states 
tissue culture) 

POIHL 14388-07 0178 
pathological states 



Regulation of the circulation in 
- Structural and functional 

consequences of denervation (rats) 
POlHL-14388-07 0179 Regulation of the circulation In 

pathological states - Cultured muscle cells and their cross- 

innervation in vitro (rats, sheep) 
POlHL-14580-07 0001 Program project in respiratory 

mechanics - Micromechanics of the lung (dogs, rats) 
ROlHL-15013-07 Lung oxidative metabolism and energy 

production (rodents, rabbits) 
ROlHL-16714-05 Endothelial cell communication in 

homeostasis (human, mammals) 
ROlHL-l 7370-03 Synaptic chemistry and cardioregulation 

in Limulus 



22 

P50HL 17667-04 0031 Study of ischemic heart disease • 

Pathophysiology in ischemic heart disease (dog. cat. rabbit 

monkey) 
ROlHL-l 771 1-05 Mechanism of hypoxic regulation of lung 

circulation (rats, cats, guinea pigs) 
ROlHL-l 7768-04 Development of collateral ventilation 

(dogs, fish, horses) 
POIHL 17812-04 0005 Thrombosis and plasma proteins - 

In vitro systems of normal platelets, white cells, sera 

(human) 
POlHL-1 7812-04 0007 Thrombosis and plasma proteins - 

Blood components -Response to endotoxin (dogs, baboons) 
ROlHL-1807004 Regulation of intrapulmonary airways 

and vessels (human animals) 
ROlHL-1819104 Models of hypoxic pulmonary 

hypertension (cattle, minipigs) 
ROlHL-18502-03 Enzymatic regulation of platelet function 

(human) 
POIHL 18576-03 0001 Thrombosis research program 

project - Platelet da nage from physical forces and 

artificial surfaces (human) 
ROIHL 18584-03 Effects of physical forces on platelets 

(human) 
P50HL-18828-03 0004 Specialized center of research in 

thrombosis - Membiane changes in platelet physiology-Role 

of complement (mite, human) 
ROIHL 18936-02 heart preservation and transplantation 

studies (rat) 

Experimental neurogenic 
Monoamines and hypertension 



POlHL-18974-03 0008 
hypertension program 
(rats) 

POlHL-18974-03 0011 
hypertension program 



Experimental neurogenic 
. „ Biochemistry and regulation of 

brain tryptophane hydroxylase (rats) 
P50HL19153-02 0002 SCOR -Pulmonary edemas -Eitology. 

pathogenesis - Lunp fluid dynamics -Classical mediators 

and their inhibitors (sheep) 
POIHL 19242-02 000/ Study of vascular smooth muscle 

NE release in and reactivity of vascular smooth muscle 

(animals) 
R23HL-1957301 Studies on pulmonary serotonin (mice) 
POlHL-19717-02 000. Response of the lung to mjury - 

Cellular level studies of prostaglandin-like molecules 

(cattle) 
ROlHL-201 14-02 Collagen-platelet interaction and human 

aorta collagen (human) 
ROlHL-20411-03 Platelet fatty acid metabolism in 

diabetes (rat, rabbit, guinea pig) 
R01HL-21I15-01 Prevention of 02 toxicity with superoxide 

dismutase (rats) 
R23HL 21116-02 Mechanisms of membrane and tissue 

damage in lung (dogs, rabbits) 
ROlHL-21217-01 

platelets 



Ion and 5-hydroxytryptamine transport by 
Perinatal control of the ductus arteriosus 



R23HL-2140902 

(sheep) 
ROlHL-22040-01 Regulation of lysyl-cross-linking in 

vascular tissue (rats, turkeys) 
ROlHL-2207701 Vasoactive amine disposition In cultured 

endothelium (rabbits) 
ROlHL-22177-02 Mechanisms of control of pulmonary 

smooth muscle (dogs) 
ROlHL-22223-01 The cardiopulmonary junction (dogs, 

models) 
ROlHL-22244-01 Cardiopulmonary bypass and the 

vascular endothelium (dogs) 
ROIHL 22555-01 Structure and function of platelet 

activating factor (rabbits, human) 
R01HL-2256I-01 Hormonal control of mesenteric 

circulation (cats) 
ROlHL-22573-01 Treatment of post surgical 

vasoconstriction (dogs, monkeys human rats) 
POlHL-22619-01 0008 Cellular mechanisms of heart 

failure - Molecular mechanisms and differential contractile 

responsiveness In VSM (dogs) 
ROlHL-23614-02 Pharmacology of relaxation in smooth 

muscle (mollusks) 

BENZOPYRROLES, SEROTONIN INHIBITORS 

SEE ALSO ALKALOIDS. ERGOT. METHYSERGIDE 

SEE ALSO CYCLIC AMINO ACIDS, PHENYULANINE P- 

CHLOROPHENYLALANINE 
SEE ALSO CYCLOHEPTANES. CYPROHEPTADINE 
" P50HL-19I53-02 0002 SCOR -Pulmonary edemas -Eitology. 
pathogenesis - Lung fluid dynamics-Classical mediators 
and their inhibitors (sheep) 
ROlHL-22520-01 Pulmonary vascular response to group 8 

Streptococci (human, mammals) 
ROlHL-22573-01 Treatment of post surgical 
vasoconstriction (dogs, monkeys, human, rats) 

BENZOQUINONES 

SEE QUINONES 

BENZYLPENICILLINIC ACID 

SEE ANTIBIOTIC:;. PENICILLIN G 
BERBERINE 

SEE ALKALOIDS BERBINES 
BERBINES 

SEE ALKALOIDS BERBINES 



•Excludes toutinc methodology OR covers only general projects which preclude indexing at the specific level 
Oriented significanlly to above sub|ecl. 



M Grant has subproiects describing specific research aspects. 
See Appendix for investigators name and grant number 



BIL 
BERYLLIOSIS 

SEE METALS POISONING, BERYLLIOSIS 
BERYLLIUM (COMPOUNDS) 

SEE METALS, ALKALINE EARTH METALS. BERYLLIUM 
BETA GLOBULIN(S) 

SEE GLOBULINS, BETA GLOBULINS 
BETA RECEPTORS 

SEE NEUROTRANSMinERS RECEPTORS ADRENERGIC 
RECEPTORS, BETA RECEPTORS 

BETATRON 

SEE RADIATION, PARTICLE ACCELERATORS 
BETHANIDINE 

SEE GUANIDINES. BETHANIDINE 
BIBLIOGRAPHY 

SEE PUBLICATIONS. LITERATURE SURVEY 

BICARBONATES 

SEE CARBONATES. BICARBONATES 
BICUSPID VALVE 

SEE HEART. VALVES, MITRAL VALVE 
BIG BIG GASTRIN 

SEE GASTROINTESTINAL HORMONES. GASTRIN 
BIG GASTRIN 

SEE GASTROINTESTINAL HORMONES. GASTRIN 
BILE 

ROlHL-09744-14 Experimental vascular sclerosis 
(monkeys, rabbits) 
** ROlHL-15698-12 Factors affecting the action of 
anticoagulants (rats, human) 
ROIHL 22567-01 Validation of a cholesterol absorption 
method in man 

BILE, CHOLAGOGUES AND CHOLERETICS 

SEE ALSO BILE ACIDS AND SALTS 

SEE ALSO BILE ALCOHOLS 

SEE ALSO GASTROINTESTINAL HORMONES, PANCREOZYMIN- 

CHOLECYSTOKININ 
SEE ALSO GASTROINTESTINAL HORMONES. SECRETIN 
♦* ROlHL-22748-01 Effect of bile sequestration on VLDL 
metabolism (human) 

BILE ACIDS AND SALTS 

SEE ALSO BILE. CHOLAGOGUES AND CHOLERETICS 
ROlHL-02033-23 Regulation of cholesterol esters in blood 

and tissues (rat. cattle, human) 
ROlHL-03299-21 Dietary effects on cholesterol metabolism 

(rats, rabbits) 
R01HL-06222-18 Chnical and laboratory studies In lipid 
metabolism (human, mammals, non-human) 
** ROlHL-0787816 Metabolism of neutral sterols (rats, 
rabbits) 
P01HL-08214-15 0041 Chemical and biological properties 
of lipids - Physico-chemical regulation of enzymes in lipid 
metabolism 
POlHL-08899-14 0061 Tolerance to respiratory gases in 
health and disease - Hepatic oxygenation and secretory 
functions (rats, dogs) 
P01HL08974-14 0024 Natural and experimental 
atherosclerosis - Atherosclerosis, sterol and lipoprotein 
metabolism in nonhuman primates 
** ROlHL-09610-14 Control of cholesterol metabolism-Bile 
acid transport 
R01HL-I0894-12 Intestinal bacteria and steroid 
metabolism (human, guinea pigs rabbits rats) 
" ROlHL-l 1901-12 0004 Effects of metabolic surgery on 
the hyperlipidemias ■ Ileal bypass -Cholesterol dynamics 
studies (rats, rabbits, dogs) 
" ROIHL 11901-12 0013 Effects of metabolic surgery on 
the hyperlipidemias - Human cholesterol and bile acids 
dynamics -ileal bypass 
ROIHL-1 1901-12 0015 Effects of metabolic surgery on 
the hyperlipidemias - Portacaval shunt for cholesterol 
reduction (dogs, rabbits) 
" ROIHL 11901-12 0019 Effects of metabolic surgery on 
the hyperlipidemias - Cholesterol, bileacids. lipoproteins in 
obese humans 
R01HL-I1901-12 0020 Effects of metabolic surgery on 
the hyperlipidemias - Je|uno-ileal bypass -Endogenous 
animal model of obesity (rats) 
ROlHL-16364-04 Regulation of lipid biosynthesis and 

transport (rats, swine. Xenopus) 
ROlHL-16796-05 Cholesterol regulation by HMG-CoA 

reductase (rats, human) 
ROlHL-17332-04 Use of the gut for therapy of coronary 

artery disease (mammals) 
ROlHL-17564-03 Unsaturated fats-Mode of 

hypocholesterolemic action (minipig) 
R01HL-I7818-05 Metabolism of cholesterol and cholesterol 

in man (also rats, monkeys) 
R01HL-I8219-04 Regulation of cholesterol metabolism 

(rats) 
P50HL-I9362-02 0009 A7S SCOR -Atherosclerosis in 
nonhuman primates - Cholesterol metabolism and 
intestinal microflora (baboon) 
ROlHL-20483-03 Sterol balance and cholesterol absorption 
in diabetics (human) 

(contd) 



Bll 

raiHl 77633 01 0007 Collulir and molnculai biology al 
lipoprolain mttabolism Sterol metabolism m tissue 
ciiltuie crIU 

KlMHL ?.t^98 01 Dietary tat rholestrrol and bile icid 
luinover (i.it\) 

BILE ACIDS AND SALTS, ENTEROHEPATIC 
CIRCULATION 

ROIHl 10894 I? Intestinal bacteria and steroid 
metabolism (human. (Uinea pigs, rabbits, rats) 

BILE ALCOHOLS 

SEE ALSO BIIE. CHOUGOGUES AND CHOIEREIICS 
ROIHl 10894 I? Intestinal bacteria and steroid 

metabolism (human, guinea pigs, rabbits, rats) 
ROIHL 17818 05 Metabolism ol cholesterol and cholesterol 

in man (also rats, monkeys) 

BILE (DUCT) OBSTRUCTION 

SEE BILIARY TRAC1 DISORDERS. BILE OBSTRUCTION 

BILE PIGMENTS 

SEE ALSO JAUNDICE 

ROIHL 7148301 Electronic, thermodynamic and kinetics 
ol hemoglobin 

BILE PIGMENTS, BILIRUBIN 

ROIHL'77752'01 Synthesis of labeled hemes (or protein 
NMR studies 

BILHARZIASIS 

SEE PARASITIC DISEASES. HELMINTH INFECTIONS. 
SCHISTOSOMIASIS 

BIUARY ATRESIA 

SEE BILIARY TRACT DISORDERS. BILIARY ATRESIA 

BILIARY CALCULI 

SEE BILIARY TRACT DISORDERS. CHOLELITHS 

BILIARY TRACT DISORDERS, BILE OBSTRUCTION 

SEE ALSO BILIARY TRACT DISORDERS. BILIARY ATRESIA 
SEE ALSO BILIARY TRACT DISORDERS. CHOLELITHS 
R01HL02965-22 Metabolism of plasma lipoproteins (rats, 

chickens, human) 
ROlHL-0622117 Composition and structure of plasma 

lipoproteins (human, turkeys, baboons] 
P50HL-1423707 0004 Support for arteriosclerosis center 

- Synthesis, secretion of normal, abnormal plasma 

lipoproteins (rodents, monkeys) 
ROlHL-23945-06 Pathologic effects on cells of modified 

lipoproteins (rats, human) 

BILIARY TRACT DISORDERS, BILIARY ATRESIA 

R01HL06221-17 Composition and structure of plasma 
lipoproteins (human, turkeys, baboons) 

BIUARY TRACT DISORDERS, CHOLELITHS 

POlHL-0683517 0016 Cardiovascular disease ■ Metabolic 

interactions to polyunsaturated fatty acids in atherogenic 

diet (dogs) 
R01HL09744-I4 Experimental vascular sclerosis 

(monkeys, rabbits) 
R01HL10894-12 Intestinal bacteria and steroid 

metabolism (human, guinea pigs, rabbits, rats) 
R01HL11901-12 0013 Effects of metabolic surgery on 

the hyperlipidemias - Human cholesterol and bile acids 

dynamics-ileal bypass 
•* P60HL1516905 0012 Support for center for sickle cell 

disease - Evaluation of the incidence of cholelithiasis in 

sickle cell disease (human) 
** ROlHL-1781805 Metabolism of cholesterol and cholesterol 

in man (also rats, monkeys) 
** R01HL-18623I2 Physical chemistry of biologically active 

lipids (bacteria, plant, cattle, human) 
NOlHV-22913-09 Lipid research clinic 
NOlHV-62900-00 Study of breast cancer and reserpine use 

(human) 

BILIARY TRACT DISORDERS, GALLBLADDER 
DISORDERS 

SEE ALSO BILIARY TRACT DISORDERS. CHOLELITHS 
ROlHL-19839-09 Factors in youth predisposing to chronic 
diseases (former college students) 

BILIARY TRACT DISORDERS CHEMOTHERAPY 

SEE ALSO BILIARY TRACT PHARMACOLOGY 
SEE ALSO LIVER DISORDERS CHEMOTHERAPY 
ROlHL-1089412 Intestinal bacteria and steroid 
metabolism (human, guinea pigs, rabbits, rats) 

BILIARY TRACT DISORDERS DIAGNOSIS (INCL 
EXAMS)* 

SEE ALSO LIVER DISORDERS DIAGNOSIS (INCL EXAMS)* 
R01HL06221-17 Composition and structure of plasma 

lipoproteins (human, turkeys, baboons) 
P60HL-15169-05 0012 Support for center for sickle cell 

disease - Evaluation of the incidence of cholelithiasis in 

sickle cell disease (human) 

BILIARY TRACT EXAMINATIONS 

SEE BILIARY TRACT DISORDERS DIAGNOSIS (INCL E)(AMS)* 
BILIARY TRACT OBSTRUCTION 

SEE BILIARY TRACT DISORDERS. BILE OBSTRUCTION 



23 

BILIARY TRACT PHARMACOLOGY 

Sff ALSO BILIARY IRACI UISORDIHS CHEMOTHERAPY 
SEE ALSOIIVIR I'llARMACOlOGY 
" ROIHl 72/48 01 llteil ol bile sequestration on VtOt 
mptabolism (human) 

BILIRUBIN 

SEE BILE PIGMENTS BIIIRDBIN 

BINDING (CHEMICAL) 

SEE CHEMICAI BONDS BINDING 

BINDING PROTEINS 

SEE PROtEIN BINDING 

BINDING REAGENTS 

SEE METAL COMPLEXES. LIGANDS 

BIOANALYTICAL AND METALLOBIOCHEMISTRY 
STUDY SECTION 

•• ROIHL 13651 07 

compounds 
•* R01HL2225201 



NMR studies 
ROIHL 2238701 
ROIHL 2282101 

myoglobinemia 
ROIHL 23120 01 



X ray pholoelectron spectroscopy of heme 
Synthesis ol labeled hemes for protein 



Metalloen;ymes and disease 
A routine screening analysis for 

Chelating agents as blood substitutes 



BIOASSAY* 

SEE ALSO CHEMICAL STRUCTURE BIOLOGICAL ACTIVITY 
SEE ALSO IMMUNOLOGICAL TESTS AND IMMUNOASSAY, 
IMMUNOASSAY* 
NOIHB 8292400 Source of human urinary erythropoietin 
NOlHB-8292600 Source of human urinary erythropoietin 
POlHL-06312 17 0052 Surgical cardiology • Assay of 

metabolic variables of rat heart 
ROIHL 11172-12 Physiology and biochemistry of 

fibrinolytic enzymes (human, animals) 
POIHL 11310-12 0096 Mechanisms of cardiovascular 
disease Complement chemistry and biology (human, 
rabbits) 
P50HL14164-07 0040 A/S SCOR-Comparative and 
experimental atherosclerosis - Core angiochemistry 
laboratory 
ROlHL-1489007 Platelet prostaglandms (human, rabbits) 
ROlHL-16346-09 Enzyme assay for blood clotting (human) 
R01HL1793003 Platelet membrane function -Assessment 

and application (animals) 
ROlHL-18908-03 Angiotensin converting enzyme of human 

serum 
P50HL1915702 0001 Studies in cystic fibrosis and 
bronchiolitis - Laboratory core unit 
*• P50HL-19157-02 0004 Studies in cystic fibrosis and 
bronchiolitis - Macromolecular regulators of mucus 
secretion-Invertebrate model 
** P50HL-19157-02 0007 Studies in cystic fibrosis and 

bronchiolitis - Analysis of cystic fibrosis factors (human) 
** ROlHL-19272-03 Studies on the Passovoy factor (human) 
** ROlHL-19331-03 Hirudin Isolation and utilization (leeches) 
R23HL-2 1208-02 Structure-function relationships of human 

factor VIII 
R01HL-23312-0I Hemodynamics and vasoactivity In renal 
hypertension (human, dogs) 

BIOAUTOFUEL CELL 

SEE BIOMEDICAL ENGINEERING, BIOLOGICAL POWER 
SYSTEMS 

BIOAVAILABILITY OF DRUGS 

SEE DRUGS, PHARMACOLOGY, BIOAVAILABILfTY / 

BIOCHEMICAL EVOLUTION 

SEE BIOLOGY, SYSTEMATIC, EVOLUTION BIOCHEMICAL 

BIOCHEMICAL INFORMATION SYSTEMS 

SEE CHEMICAL AND DRUG INFORMATION SYSTEMS 

BIOCHEMICAL PHARMACOLOGY 

SEE DRUGS, PHARMACOLOGY. BIOCHEMICAL 

BIOCHEMISTRY (GENERAL)* 

SEE ALSO MICROBIAL CHEMISTRY STUDY SECTION 

SEE ALSO MOLECUUR BIOLOGY 

SEE ALSO PHYSICAL PROPERTIES. RHEOLOGY (NOT INCL. 

BLOOD) 
SEE ALSO PHYSIOLOGICAL CHEMISTRY STUDY SECTION 
ROIHL-02942-22 Biochemistrv of cardiovascular connective 
tissue (human, cattle, primates) 
** PG1HL-06285-18 0178 Cardiovascular-respiratory 

physiology and biochemistry - Biochemical regulation of 
hypertrophy (rats, rabbits) 
** P01HL-12373-10 0018 Cardiopulmonary physiology and 

pathophysiology - Biochemistry laboratory 
** POlHL-1373707 0031 Assisted circulation - Myocardial 
ischemia -Biochemical changes (dogs) 
ROIHL-1919503 Hormonal regulation of lung function 

(rats) 
POlHL-19717-02 0001 Response of the lung to injury - 
Lung elastic tissue (animals) 
M ROlHL-20079-02 Thromboresistant material 

POlHL-2055202 9001 The development and regression of 
cardiac hypertrophy - Core A -Pathology 



Ammo acid analyzer for biochemical 
Bioenergetics apparatus in heart 



klO 

POIHl 705111 01 0004 Vatculir nturotttfcloi 
mtchanitms in heilth and dl^eau Neurotllector 
ch«(icl«ristici of moenleiic and pulmonary blood vtiwll 
(rabbits) 

•• POIHI 20SKI 01 9007 Vaiculai neuioelleclof 

mechanisms in health and diseiM Biochemiilry con 
POIHI 70S94 07 9001 Dynamics ol neutrophil (lattaM in 

the lunc BiochirmiMry and immunology core 

•• ROIHl 724/1 01 Biochf mislry ol prothrombin quick 
(human) 

BIOCHEMISTRY, CLINICAL 

Sir CHEMISIRY. ClINICAl 

BIOCHEMISTRY STUDY SECTION 

SEE ALSO PATHOBIOLOGICAl CHEMISTRY STUDY SECTION 
** ROIHL 07558 7? Structure function relationships in the 

heme proteins (human, cattle) 
** ROIHL 08299 16 Molecular biology of hemeryfhiin and 

hemocyanin (invertebrates) 
•* ROIHL 09364 14 Ion transport by heart mitochondria 

(cattle, rat. rabbit) 
** R01HL1111917 

research 
** ROIHL 12576 10 

mitochondria 
*• ROIHL 12585 10 Structural properties of ma late 

dehydrogenase (swine) 
** ROIHL 1303508 Heart mitochondrial malate 

dehydrogenase regulation 
** ROIHL 1361909 Microsomal electron transport in liver 

and heart (human, mammals) 
** ROIHL 14483-08 Energy conservation in heart 

mitochondria (cattle, E coli, human) 
** ROlHL-1500207 Biochemical pharmacology of guanylate 

cyclase in lung (cattle, rats) 
** ROIHL 1501307 Lung oxidative metabolism and energy 

production (rodents, rabbits) 
** ROIHL 15104-07 A mechanism for oxidative 

phosphorylation 
** ROlHL-15476-05 Mechanism and control of sterol 

biosynthesis (rats) 
** ROIHL 15535-06 Structure and function of human plasmin 
** ROlHL-1589205 Inhibitors of proteinases (human, cattle, 

swine) 
** ROlHL-16549-04 Cardiotonic steroid NaK ATPase 

interactions (cattle) 
** R01HL16647 05 Studies on the control of sickle cell crisis 

(human) 
** ROlHL-16686-04 

bacteria) 
** ROlHL-1737203 Adenine nucleotide maintenance in the 

ischemic heart (rats) 
** R01HL1796304 Human erythrocyte carbonic anhydrase 
** ROlHL-1803803 Structure and function of heart 

mitochondria (cattle) 
** ROIHL'18095'04 Human dopamine-betahydroxylase (also 

cattle) 
** ROIHL-18179-03 Heart, platelet, and muscle myosins and 

actomyosins (cattle) 
** ROlHL-18554-03 Taurine metabolism in mammalian heart 

(rodents, cattle, swine) 
** R01HLI8567-03 A routine diagnostic test for minimal 

heart damage (human, rat) 
** ROlHL-18593-03 Characterization of heart valve collagen 

(human, pig) 
** R01HL18682-03 Protein kinase and cholesterol 

metabolism in aorta (rabbits) 
** ROlHL-19181-02 Regulation of heart cAMP-dependent 

protein kinase (rodents) 
** ROIHL 19532-01 Oxygen toxicity In the red cell (human) 
** R01HL-19654-03 Biochemical-pharmacological evaluation 

of lung cells (rabbits) 
** ROlHL-2011601 Heart lactate dehydrogenase -The complex 

with NADH (pig) 
** ROlHL-20544-02 Integrated regulation of myocardial 

energy metabolism (rats, guinea pigs) 
•* ROlHL-20658-01 Myocardial energy transport -Creative 

kinase (human, cattle, dog) 
** ROlHL-2090902 Clofibrate-enhanced lipid oxidation by 

peroxisomes (rats) 
** R23HL-2142101 Myocardial and vascular contractility and 

cyclic nucleotides (cattle, rats) 
" ROlHL-2226502 Isozymes of heart glutamate aspartate 

transaminase (swine, ducks) 
** ROlHL-2229001 Cardiac energy metabolism and protein 

synthesis (mice) 
** R23HL-22383-01 Biosynthesis -Response to oxygen 

depletion (human, primates, rats) 
** ROlHL-22486-01 

cells (swine) 
** ROlHL-22538-01 



Properties of cytochrome oxidase (cattle. 



•Excludes routine methodology OR covers only general proiecls which preclude indexing at the specific level, 
"Oriented significantly to above subject. 



Enzyme regulation in cultured arterial 

Myosin as a multi-enzyme complex (dogs. 

rabbits) 
** ROlHL-22896-01 Immediate metabolic fates of kinins and 

angiotensins (rat, rabbit, guinea pig) 
** R23HL-22984-01 Cyclic AMP dependent protein kinases in 

hypertension (rat) 

BIOCYBERNETICS 

SEE INFORMATION PROCESSING AND CONTROL (BIOLOGICAL) 

BIOCYBERNETICS (NEURAL) 

SEE INFORMATION PROCESSING AND CONTROL (NEURAL) 

(contd) 



M Grant has subprojects describing specific research aspects 
See Appendix for investigator's name and grant number 



BIO 

BIODEGRADATION, BIOTRANSFORMATION 
(METABOLISM) 

SEE METABOLISM, BIOTRANSFORMATION 

BIOELECTRICITY 

SEE ELECTROPHYSIOLOGY 

BIOENERGETICS 

SEE ALSO BIOLOGICAL TRANSPORT 
SEE ALSO MUSCLE METABOLISM 
SEE ALSO OXIDATION-REDUCTION 
SEE ALSO OXIDATIVE PHOSPHORYLATION 
SEE ALSO PHOTOBIOLOGY 
SEE ALSO PHOTOCHEMISTRY 
R01HL02363-20 Kinetics of water and electrolytes in 

shock (dogs, rats) 
R01HL05949-18 Biochemistry of muscle contraction (rats, 

rabbits) 
POlHL-06285-18 0195 Cardiovascular-respiratory 
physiology and biochemistry - Thyroid thermogenesis and 
sodium transport (rats) 
POlHL-06285-18 0211 Cardiovascular-respiratory 
physiology and biochemistry ■ Purple membrane of 
Halobacteria 
POlHL-06664-17 0036 Cardiopulmonary function in 
remediable vascular disease - In vitro studies on the 
mechanism of ischemic damage to cells (rabbits) 
P01HL06664-17 0040 Cardiopulmonary function in 

remediable vascular disease - The coupling of ion transport 
to metabolism (toads) 
R01HL10018-11 Effect of aging on beating heart cells in 

culture (rats) 
POlHL-1 1310-12 0068 Mechanisms of cardiovascular 
disease - Pharmacological intervention and myocarcial 
oxygen consuption (human, dogs) 
*♦ P01HL1131012 0094 Mechanisms of cardiovascular 
disease - Physics of pulsatile fluid flow (dogs) 
POIHLI 1310-12 9001 Mechanisms of cardiovascular 
disease - Core support-hospital beds 
M POlHL-l 1351-12 Cellular and molecular mechanisms of 
myocardial function 
POlHL-l 1351-12 0004 Cellular and molecular 
mechanisms of myocardial function ■ Molecular 
mechanisms of contractile function and differentiation 
(animals) 
** POIHLI 1351-12 0006 Cellular and molecular 

mechanisms of myocardial function ■ Molecular physiology 
and energetics of muscle (frogs) 
** P01HL11351-12 0015 Cellular and molecular 

mechanisms of myocardial function ■ Effects of hypoxia 
and ischemia on ion exchange and heart function (rabbits) 
** POlHL-11351-12 0019 Cellular and molecular 

mechanisms of myocardial function ■ Mechano-chemical 
kinetics of small perturbations 
** POlHL-11351-12 0021 Cellular and molecular 

mechanisms of myocardial function - Muscle energetics 
(frogs) 
** P01HL-1135M2 0022 Cellular and molecular 

mechanisms of myocardial function - Energetic sequelae of 
shortening-Myothermal and biochemical (frogs) 
** P01HL11351-12 0023 Cellular and molecular 
mechanisms of myocardial function ■ Energetics of 
mammalian muscle (rats) 
POlHL-1 1351-12 0024 Cellular and molecular 
mechanisms of myocardial function - Steady state and 
transient kinetics of frog myosin, SI, and ATPase 
ROlHL-1 1906-11 Comparative study of heart function 

(cats, rats, hedgehogs, squirrels) 
POlHL-12157-11 0049 Functions and mechanisms of cell 
membrane ion transport - Ouabain-insensitive cation 
transport in duck red cells 
ROlHL-1257610 Bioenergctics apparatus in heart 

mitochondria 
ROlHL-13651-07 X-ray photoelectron spectroscopy of heme 

compounds 
POlHL-1373707 0005 Assisted circulation - Piezoelectric 
assist device (animals) 
** P50HL-14138-05 0015 Center for research on 

atherosclerosis - Arterial wall-Intermediary metabolism, 
enzyme activity and bioenergetics 
** P50HL-14217-08 0057 Specialized center of research in 
thrombosis - Pharmacology--Platelet biochemistry (human, 
animal) 
P50HL-1421708 0058 Specialized center of research in 
thrombosis • Mechanisms of induction and inhibition of 
platelet reaction (human, pig) 
** P50HL14217-08 0059 Specialized center of research in 
thrombosis - Energy metabolism and platelet function 
(human) 
** R01HL1434407 Platelet function and adenine nucleotide 

metabolism (human) 
** P01HL14388-07 0154 Regulation of the circulation in 

pathological states - Energetics of smooth muscle 
contraction (rats) 
POlHL-14388-07 0175 
pathological states - 
from cardiac muscle 
** POlHL-1441407 0008 Environmental influences on 

cardiorespiratory and cellular functions - Energetics of 
swimming (human) 
** ROlHL-14461-08 Cardiac metabolism in heart failure 
(rats) 



Regulation of the circulation in 
Functional studies of selected proteins 



24 



R01HL14820-07 Factors affecting physiology of biological 

membranes (human) 
ROlHL-150 13-07 Lung oxidative metabolism and energy 

production (rodents, rabbits) 
ROlHL-1528406 Hemoglobin and myoglobin kinetic 

studies (human, animals) 
POlHL-1583506 Study of muscles related to heart 

disease 
P01HL1583506 0010 Study of muscles related to heart 

disease - Muscle structure and reaction to injury (mice, 

rats) 
POlHL-15835-06 0011 Study of muscles related to heart 

disease - Energetics and mechanism of muscle contraction 

(frogs, rabbits) 
POIHL 15835-06 0012 Study of muscles related to heart 

disease - Contraction and energetics of visceral and 

vascular smooth muscles (rabbits) 
P01HL1583506 0013 Study of muscles related to heart 

disease - Cardiac bioenergetics (rats) 
ROlHL-16101-05 Protein-lipid interaction (bacteria, 

models) 
P01HL1625106 0009 Membrane-bound enzymes in heart 

and other tissues NADH dehydrogenase and site I of 

oxidative phosphorylation (yeast) 
P60HL-17269-04 0018 National heart and blood vessel 

research and demonstration center Mitochondria and 

energetics (rabbits, dogs) 
P60HL-17269-04 0019 National heart and blood vessel 

research and demonstration center • Sarcoplasmic 

reticulum (dog. rabbit, hamster, cat) 
R01HL1759203 Activation and contraction heat in 

enlarged hearts (rabbits) 
P50HL1 766504 0029 Study of ischemic heart disease • 

Myocardial protein synthesis and degradation in low oxygen 

states (rabbit, dog) 
P50HL17667-04 0012 Study of ischemic heart disease - 

Biochemistry of normal and ischemic heart -Glycolysis (rats) 
P50HL-17667-04 0022 Study of ischemic heart disease - 

Preventing myocardial injury in surgery using 

cardiopulmonary bypass (human, rat) 
P50HL17667-04 0040 Study of ischemic heart disease - 

Core biochemistry-Cardiac metabolism (human) 
' P50HL-1767004 0023 Study of ischemic heart disease ■ 

Energy metabolism in acute myocardial ischemic injury 

(dogs) 
P50HL-1768204 0018 Study of ischemic heart disease ■ 

Biochemistry of ischemia-Heart cell and organ culture 

(mice. rats, cattle) 
R01HL17736-04 Metabolic change during cardiac 

ischemia (rats, dogs) 
ROlHL-1 789504 Myocardial function and metabolism 

following ischemia (rats) 
R01HL18206-04 Regulation of metabolism in oxygen 

deficient hearts (rats) 
ROlHL-18288-04 Intraoperative protection of the 

myocardium (dogs, rats) 
ROlHL-18527-03 Subcellular response of heart to 

functional overload (hamsters, rats) 
P01HL18708-03 Oxygen, energy and contractility in 

cardiac tissue 
' POlHL-18708-03 0005 Oxygen, energy and contractility in 

cardiac tissue ■ Cytosolic calcium homeostasis and 

bioenergetics of cardiac tissue (animals) 
' POlHL-18708-03 0007 Oxygen, energy and contractility in 

cardiac tissue • Surfaces, energy requirements, and 

contractile proteins of cardiac cell in vitro 

* POlHL-18708-03 0010 Oxygen, energy and contractility in 

cardiac tissue - Tissue oxygen utilization (rats, dogs) 

* ROlHL-18933-03 Energy output and efficiency of left 

ventricle (dog) 

* POlHL-19242-02 0001 Study of vascular smooth muscle - 

Energy metabolism and protein turnover in vascular smooth 
muscle (rats) 

* ROlHL-19366-03 Renal Starling forces in experimental 

conditions (rats, rabbits) 

* ROlHL-19461-03 Myocardial energetics in hypertrophy and 

heart failure (rabbits) 
ROIHL-20286-02 Interventions to improve cardiac function 

in ischemia (dogs) 
ROlHL-20369-03 The effect of alcohol on the heart (rats) 

* ROlHL-20484-03 Effects of diabetes on cardiac function 

and metabolism (rats) 

* ROlHL-20544-02 Integrated regulation of myocardial 

energy metabolism (rats, guinea pigs) 

* POlHL-20552-02 0010 The development and regression of 

cardiac hypertrophy - Energy metabolism in the 
hypertrophied heart animals 

* POlHL-20592-02 0001 Cell biology of cardiac and 

skeletal muscle - Molecular mechanism of muscle 
contraction (animals) 

* ROlHL-21209-02 Alterations of metabolism in ischemic 

myocardium (swine) 
ROlHL-2150002 
stress (dogs) 



Performance of respiratory muscles under 
The mechanical basis of myocardial 



RGlHL-21570-01 

energetics (cats) 
ROlHL-2 1849-02 Control of sodium transport and cellular 

respiration (toad bladder) 
ROlHL-2223901 The molecular basis of electrical 

excitability (chick embryos, rats) 
ROlHL-22290-01 Cardiac energy metabolism and protein 

synthesis (mice) 



Cardiac function and metabolism in 
Performance of respiratory muscles under 
Lung metabolism and alveolo-capillaiy 



BIO 

POlHL-22619-01 0010 Cellular mechanisms of heart 

failure - Mitochondria in heart and smooth muscle (rabbits, 

rats, dogs) 
ROlHL-22729-01 Intracellular degradation of newly 

synthesized collagen (human, chick, rabbit) 
ROlHL-2298117 Membrane-associated functions in 

microorganisms (bacieria, protozoa) 
ROIHL 23240-01 Pulmonary vascular muscle metabolism 

and contractility (rats, cattle) 

BIOENERGETICS, HIGH ENERGY COMPOUNDS 

POlHL-1131012 0063 Mechanisms of cardiovascular 

disease - Myocardial function, metabolism and cellular 

integrity after heart surgery (dogs) 
P01HL11351 12 0015 Cellular and molecular 

mechanisms of myocardial function - Effects of hypoxia 

and ischemia on ion exchange and heart function (rabbits) 
ROlHL-14523-07 Generation and regulation of force in 

smooth muscle (animals) 
** ROlHL-15104-07 A mechanism for oxidative 

phosphorylation 
ROlHL-15983 04 Regional myocardial blood flow (dogs) 
ROIHL- 17629-03 Developmental aspects of cardiovascular 

function (human, cats, rabbits) 
P50HL-1767004 0023 Study of ischemic heart disease ■ 

Energy metabolism in acute myocardial Ischemic injury 

(dogs) 
ROIHL' 17853-03 Peripheral circulation in heart failure 

(animals) 
POIHL 1870803 0010 Oxygen, energy and contractility in 

cardiac tissue - Tissue oxygen utilization (rats, dogs) 
ROlHL-20177-02 Effects of erythrocyte deformability on 

tissue perfusion (rats) 
ROlHL-2028602 Interventions to improve cardiac function 

in ischemia (dogs) 
POlHL-20552-02 0010 The development and regression of 

cardiac hypertrophy ■ Energy metabolism in the 

hypertrophied heart animals 
R23HL-21393-01 Cardiac adaptation to aging and stress 

(rats) 
ROlHL-2 148201 

diabetes (rats) 
ROlHL-21500-02 

stress (dogs) 
R23HL-21853-01 

permeability (rats) 
ROlHL-22470-01 Liposome myocardial uptake in infarct 

and ischemia (dogs. rats, mice) 
POlHL-22619-01 0010 Cellular mechanisms of heart 

failure - Mitochondria in heart and smooth muscle (rabbits, 

rats, dogs) 
** R01HL-2314001 Determinants of irreversible ischemic 

injury in heart (dog, rat) 
ROlHL-23205-01 Contraction of pulmonary vascular 

smooth muscle (cat) 

BIOENGINEERING 

SEE BIOMEDICAL ENGINEERING 
BIOENGINEERING AND APPLIED PHYSIOLOGY 
STUDY SECTION 

SEE PHYSIOLOGY (APPLIED) AND ORTHOPEDICS STUDY 
SECTION 

BIOEQUIVALENCE OF DRUGS 

SEE DRUGS, PHARMACOLOGY, BIOAVAILABILITY 

BIOETHICS 

SEE HEALTH SOCIAL CONTROL 

BIOFEEDBACK CONDITIONING (TRAINING) 

SEE PSYCHOLOGY, CONDITIONING. AUTOGENIC AND INTERNAL 
CONTROL 

BIOGENIC AMINES, NEURAL 

SEE NEUROTRANSMITTERS (GENERAL) 
BIOLOGICAL BASIS (CORRELATES) OF BEHAVIOR 

SEE PSYCHOBIOLOGY. PSYCHOPHYSIOLOGY 

BIOLOGICAL BATTERIES, FUEL CELLS 

SEE BIOMEDICAL ENGINEERING. BIOLOGICAL POWER 
SYSTEMS 

BIOLOGICAL CLOCKS, RHYTHMS 

SEE BIOPERIOOICITY, BIOLOGICAL CLOCKS 
BIOLOGICAL CONTROL AND PROCESSING OF 
INFORMATION 

SEE INFORMATION PROCESSING AND CONTROL (BIOLOGICAL) 

BIOLOGICAL EFFECTS OF PESTICIDES 

SEE PESTICIDES BIOLOGICAL EFFECTS (GENERAL) 

BIOLOGICAL MODELS 

SEE MODELS, BIOLOGICAL 
BIOLOGICAL POWER SOURCES 

SEE BIOMEDICAL ENGINEERING. BIOLOGICAL POWER 
SYSTEMS 

BIOLOGICAL PREPARATIONS AND 
STANDARDIZATION 

SEE ALSO IMMUNOLOGICAL PREPARATIONS 

(GENERADdNCLUDING CERTIFICATION AND 
STANDARDIZATION) 

(contd) 



I 



( 



•Excludes routine methodology OR covers only general projects which preclude indexing at 
••Oriented significantly to above subject- 



the specific level. 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



BIO 



25 



BIO 



Slf MSO PIANIS EXTRACTS. MfOICINAl PUNTS 
*■ NOIHH SJ0.)!i04 lucloi VIII inliibitori in p<iti«i\t:i wilti 

hemophilia 
** N01HB8?924 00 Soufca ol human utinaiy •lythiopoiotin 
** rOIHlO63:>0 1/ 0018 Hamoslasis igstaich pioniam 

pioiect Vaiienlj ol taclois IX (human, cattle) 
" ROIHL IOb82 \'2 Thtombosis and homostasis Analysis, 

methods and standards (human, cattle, venom) 
" ROIHL 10880 13 Pufilication ol human eiythropoietin loi 

reseaich use 
** ROIHL 13160 08 Human thrombin (also cattle) 

ROIHL I3!i8' 06 Synthesis ol renin inhibitors and analog 
phosphatides (rats) 
■* ROIHL 13881 08 The American Red Cross National 

Fractionation Center 
** ROIHL 14262 07 Leukocyte proteases and their lun( 
targets (human, do|S. rabbits) 
POIHL 15S960S 0007 Coagulation. Iibrinolysis, 
hemostasis and hepatitis Structural studies and 
Iractionation of urokinase (human) 
ROIHL 1663304 Chemistry and biology o< factor IX 
activator (human, mice, rats) 
** ROIHL 1667505 Human urinary erythropoietin collection 
ROIHL 17726 03 Bacterial heparinase in diagnostic 

coagulation studies 
POIHL 1781304 0008 Lung disease and the oxygenation 
of blood and tissue Pulmonary regulation ol systemic 
blood pressure (human, rabbits, rats) 
** ROIHL 1861804 Purification and function of human HMW 
kininogen 
ROIHL 1982002 The chemistry and biological effects of 

heparin (Rhesus, human, other mammals) 
ROIHL 22402 01 Heparin biophysical, chemical and 

biological aspects (mice, human) 
NOIHR 72920 01 Identify and quantify cystic fibrosis 
factors (human) 

BIOLOGICAL RHYTHMS, CLOCKS 

SEE BIOPERIODICITY, BIOLOGICAL CLOCKS 

BIOLOGICAL TRANSPORT 

SEE ALSO AimiNO ACIDS TRANSPORT (GENERAL) 
SEE ALSO CARBOHYDRATES TRANSPORT (GENERAL) 
SEE ALSO FAHY ACIDS TRANSPORT (GENERAL) 
SEE ALSO LIPIDS TRANSPORT 

SEE ALSO NERVOUS SYSTEIVI, NEURONS, AXOPLASMIC FLOW 
SEE ALSO PROTEINS TRANSPORT 
SEE ALSO RESPIRATORY GAS TRANSPORT 
** POlHL-0683517 0028 Cardiovascular disease ■ Studies 

in thrombosisfibrinogen in fibrin transport (human) 
** R01HL12647-08 Inactivation of norepinephrine in vascular 
tissue 
R01HL13909-27 Physiochemistry and immunology of 

macromolecules 
ROlHL-15270-Oe Local mechanical properties of the aortic 

tissue (dogs, pigs) 
R01HL-16219-05 Mechanisms of atherogenesis in chronic 

uremia (human, rats) 
R01HL16714-05 Endothelial cell communication in 
homeostasis (human, mammals) 
** ROlHL-1691604 0011 The role of albumins in lung v»ater 
accumulation - Whole body distribution and exchange of 
albumin (rabbits, human, monkeys) 
** POIHL-1742105 0001 Regulation and exchange in the 
microcirculation - Mass transfer and microcirculatory 
function (rats) 
ROlHL-17895-04 Myocardial function and metabolism 

following ischemia (rats) 
ROlHL'18010-04 Capillary transport of large molecules 

(dogs, sheep) 
R01HL-2a62202 Pulmonary uptake and accumulation of 

drugs (rabbits, rats) 
ROlHL-20989-01 
(sheep, dogs) 
** ROlHL-21429-02 

mammals) 
** ROlHL-21438-02 Structure and permeability of arterial 
endothelium (pigs) 
ROlHL-22077-01 Vasoactive amine disposition in cultured 
endothelium (rabbits) 

BIOLOGICAL TRANSPORT, ACTIVE TRANSPORT 

SEE ALSO GASTROINTESTINAL FUNCTION, ABSORPTION- 
TRANSPORT (GENERAL) 
SEE ALSO KIDNEY FUNCTION. RENAL TUBULAR TRANSPORT 
** R01HL-04457-20 Cellular aspects of active transport (fish. 

rabbits, anurans. turtles) 
** POlHL-06664-17 0039 Cardiopulmonary function in 

remediable vascular disease - Transepithelial active 
transport and cell volume regulation (frogs) 
POlHL-07896-15 0049 Environmental biomedical research 

program - Effects of hyperbaric oxygen and pressure on 
cerebral enzymes (rats) 
ROlHL-0889314 Structure and function of membrane 

proteins (human) 
ROlHL-09364-14 Ion transport by heart mitochondria 

(cattle, rat. rabbit) 
R01HL-10503-13 Cardiac ion transport and ullrastructure 
(rats, guinea pigs, rabbits) 
M POlHL-1215711 Functions and mechanisms of cell 
membrane ion transport 



Pathophysiology of bronchial asthma 
Transport of LDL in arterial wall (human, 



" POIHI 12157 II 0033 lunciian\ and mnchanltms of cell 

inenibidiitt ion transport liniiiunology aspects of active 
Na K liansport in sheep red cell (also human, mice) 
POIHI 1215/ II 0055 Functions and mechanisms of cell 

membrane ion transport Growth and development ol 
synthetic strand heart cells in culture (chick embryo) 
" ROIHI 13256 08 Ammo acid transport by red cell 
membranes (pigeons) 
ROIHL 14092 0/ Homeostalic regulation ol plasma choline 

(rats, dogs, chickens) 
POIHI 1438807 0192 Regulation ol the circulation in 
pathological states Renal tubular sacretjon ol magnesium 
(rats) 
POIHL 14414 07 0016 Environmental influences on 

cardiorespiratory and cellular functions Effects of 
pressure on membrane and cellular function (human, 
rabbits) 
POIHL 15835 06 0011 Study of muscles related to heart 
disease Energetics and mechanism of muscle contraction 
(frogs, rabbits) 
ROIHL 15852 06 Vascular ion transport and hypertensive 

mechanisms 
ROIHL 16101 05 Protein lipid interaction (bacteria, 

models) 
POIHL 16117 05 0005 Ion movements and membranes in 

cardiovascular control Properties of isolated cell 
membranes (rabbits, cats) 
** P60HL1726904 0019 National heart and blood vessel 

research and demonstration center Sarcoplasmic 
reticulum (dog. rabbit, hamster, cat) 
•• P50HL 1764604 0012 Study ol ischemic heart disease • 
Role of microcirculation in progression of myocardial 
ischemic injury (rat) 
ROIHLI 779604 Importance of aminosugars in digitalis 
activity (cats, rabbits) 
** R01HL1787904 Molecular structure of the ouabain 

sensitive ATPase (dogs) 
" R01HL1803803 Structure and function of heart 
mitochondria (cattle) 
POIHL 18208-04 0001 Center for the study of blood cell 
rheology - Physiological basis of reversible erythrocyte 
shape change (human, firefly) 
P01HL1820804 0005 Center for the study of blood cell 
rheology - RBC deformability and capillary flow 
interrelations (human, mice) 
ROlHL-19639-02 Permeability transients of carriers, 

channels and heart 
ROlHL-20622-02 Pulmonary uptake and accumulation of 

drugs (rabbits, rats) 
ROlHL-20725-02 Mechanisms and cellular functions of ion 

transport 
R23HL'21150'02 Regulation of airway mucous glands and 
ion transport (dogs, ascaris) 
*' ROlHL-2311501 Regulation of active sodium transport 
(frogs, rats) 
ROlHL-23138-01 Myocardial ischemia (dogs, rats, chick 
embryo) 

BIOLOGICAL TRANSPORT, ACTIVE TRANSPORT, 
CARRIER MEDIATED PERMEATION 

P60HL-15999-05 0014 Miami comprehensive sickle cell 
center - Biochemical and morphological parameters of 
sickle cells (human) 

ROlHL-22135-01 Control of calcium fluxes across cardiac 
membranes (dogs, rabbits, guinea pigs) 

BIOLOGICAL TRANSPORT, ACTIVE TRANSPORT, 
ION PUMPS 

SEE ALSO BIOLOGICAL TRANSPORT, ION EXCHANGE AND 
TRANSPORT, ION CARRIERS (lONOPHORES) 
** ROIHL-01974-24 Ion-pump in the erythrocyte (rabbits, 
guinea pigs) 
POlHL-06285-18 0211 Cardiovascular-respiratory 
physiology and biochemistry - Purple membrane of 
Halobacteria 
*♦ P01HL-11310-I2 0102 Mechanisms of cardiovascular 

disease - Cardiac membrane and ion mobility (dogs) 
** P01HL12157-11 0054 Functions and mechanisms of cell 

membrane ion transport - Simulation of electrogenic ion 
transport in cardiac muscle 
** P01HL-I2157-11 0060 Functions and mechanisms of cell 

membrane ion transport - Ion transport and electrical 
properties of giant-celled aiga 
ROlHL-15793-06 Molecular aspects of erythrocyte 

membrane resealing (human) 
ROlHL-19995-02 Sensory transduction in cardiac 
mechanoreceptors (cats, frogs, rats) 

BIOLOGICAL TRANSPORT, ACTIVE TRANSPORT, 
ION PUMPS, CALCIUM PUMP 

** POlHL-06308-18 0025 Mechanisms and therapy of 

circulatory disease - Subcellular calcium pools in the 

genesis of arrhythmias (dogs) 
** POlHL-06308-18 0035 Mechanisms and therapy of 

circulatory disease - Mechanisms for electrophysiological 

changes in myocardial infarction (dogs) 
POlHL-06664-17 0036 Cardiopulmonary function in 

remediable vascular disease - In vitro studies on the 

mechanism of ischemic damage to cells (rabbits) 
ROlHL-0850815 Cardiac conductivity and automaticity 

(human, dogs, rabbits) 
ROlHL-09234-13 Amino acids of contractile proteins of 

failing hearts (dogs, hamsters) 



POIMI 11151 17 0002 Cellular and molxulai 

mechanisms rif myoraidial lunclion ifferls uf hypuiia 
and isr.hrmia on ionic eichange (rats, labfjitt) 
POIHI 11351 12 0004 Cellular and molecular 

mechanisms ol myoiaidial lunilion Molecular 
mechanisms ol contiailile function and diffeienlialion 
(animals) 
POIHI 1 1 351 12 0009 Cellular and molecular 

mechanisms of myocardial function Myocardial membrane 
surface coat (rats, rabbits) 
POIHI 11351 12 0010 Cellular and molecular 

mechanisms of myocardial function Basic ionic (ichangc 
studies (rats) 
POIHL 11351 12 0011 Cellular and molecular 

mechanisms of myocardial function Comparative 
contractile tissue studies (animals) 
POIHL 1 1351 12 0013 Cellular and molecular 

mechanisms of myocardial function Ion exchange in the 
perfused septum high resolution technique (rabbits, rats) 
ROIHL 11880 10 Physiology and pathology ol blood 

platelets (human, dogs) 
ROIHL 1218609 Calcium transients in striated muscle 

and other cells (mammals, frogs) 
POIHL 12373 10 0006 Cardiopulmonary physiology and 

pathophysiology Fatty acid metabolism Regulation, 
implications (human, mammals, birds) 
POIHL 12738 10 0044 Physiologic pharmacology and its 

clinical applications Cardioactive drugs and 
electrophysiological properties of cardiac cells (sheep) 
POIHL 12738 10 0109 Physiologic pharmacology and its 

clinical applications Effects of calcium blockers on 
skeletal and cardiac muscle (cats) 
P01HL12738 10 OHO Physiologic pharmacology and its 

clinical applications Physiology and pharmacology of 
arrhythmias (dogs) 
ROIHL 12774 08 Ionic coupling in activation of cardiac 

muscle (frogs, guinea pigs) 
ROlHL-13256 08 Ammo acid transport by red cell 

membranes (pigeons) 
ROlHL-1330608 Pharmacological control of cardiac 

membrane currents (cattle, rabbits) 
ROIHL 13375 09 Cellular potential changes causing 

cardiac arrhythmias (dogs) 
ROIHL 13454-08 Behavioral stress and cardiomyopathy 

(monkeys, cats) 
P50HL-14217-08 0059 Specialized center of research in 

thrombosis - Energy metabolism and platelet function 
(human) 
ROIHL 14775 08 Mechanisms of drug action in vascular 

smooth muscle (dog. rabbits) 
POlHL-1498507 0012 Adaptation to hypoxia - Direct 
effect of hypoxia on pulmonary vascular smooth muscle 
(rats, dogs) 
PO 1 HL- 1 5 1 9407 0004 Pathophysiology of 
cardiopulmonary dysfunction - Specialized electrophysiology 
fibers -Electrogenic basis of glycosides (mammals) 
ROlHL-15522-06 Influence of mannitol on ischemia 

cardiac muscle (dogs, cats, rats) 
ROlHL-15580-06 Humoral control of pulmonary and 

systemic circulation (animals) 
ROlHL-15692-07 Force and speed in skeletal and cardiac 

muscle 
ROlHL-15764-05 CAMP dependent protein kinase in 

cardiac contraction (dogs) 
POlHL-15835-06 0018 Study of muscles related to heart 
disease - Pharmacology of excitation coupling in muscle 
(frog, barnacles) 
' P01HL15835-06 0021 Study of muscles related to heart 

disease - Fast kinetic studies in muscle subcellular 
organelles (animals) 
ROIHL- 15888-05 Comparative stereology of the 

myocardium (birds, mammals) 
P60HL-15999-05 0014 Miami comprehensive sickle cell 

center - Biochemical and morphological parameters of 
sickle cells (human) 
P60HL-16008-06 0018 Wayne State University 

comprehensive sickle cell center - Hemoglobin S and RBC 
membranes -Pathogenesis of irreversibly sickled cells 
R01HL16052-05 Cardiac glycosides-Mechanism of 
inotropic action (dogs) 
' POlHL-161 17-05 0008 Ion movements and membranes in 

cardiovascular control - Arterial smooth muscle calcium 
fluxes and contractility (rabbits) 
' R01HL16135-05 Mechanisms of cardiac autorhythmicity 
(dogs, bats) 
ROlHL-1615206 Electrophysiology of neonatal to adult 

heart (cats, frogs, guinea pigs) 
ROlHL-16240-05 The cardiac histamine receptor (rabbits. 

guinea pigs) 
ROlHL-16454-03 Vascular muscle reactivity m 

hypertension (human, rats) 
POlHL-16607-05 Calcium ion and control of 
cardiovascular function 
' POlHL-16607-05 0001 Calcium ion and control of 

cardiovascular function • Bilayer lipid membranes, 
antibiotic probes, and SR function 
' POlHL-16607-05 0003 Calcium ion and control of 

cardiovascular function - Calcium transport in 
sarcoplasmic membranes (animals) 
* POlHL-1660705 0005 Calcium ion and control of 

cardiovascular function - Chemical modifications of the 
sarcoplasmic reticulum membranes (rabbits) 

(contd) 



^Excludes routine methodology OR covers only general projects which preclude indexing at the specific level- 
**Oriented significantly to above subject. 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigator's name and grant number 



BIO 



26 



POlHL-16607-05 0006 Calcium ion and control of 

cardiovascular function - Sarcomere and contractile 

dynamics of striated muscle cells (animals) 
R01HL1670604 Excitation-contraction coupling and heart 

failure (dogs, rabbits) 
ROlHL-16710'03 Myocardial subcellular localization of 

calcium (dogs) 
POIHL'16833'04 0011 Hemoglobin and red cell system In 

hemoglobinopathies - Relationship between hemoglobin and 

R6C membrane In sickling cells (human, rats) 
POlHL-16833-04 0016 Hemoglobin and red cell system in 

hemoglobinopathies ■ Calcium-indiced membrane damage 

in Hb SS disease (human, animals) 
ROlHL-17592 03 Activation and contraction heat in 

enlarged hearts (rabbits) 
R01HL1763105 Experimental congestive heart failure and 

hypertrophy (cats) 
ROlHL-17702-04 Electro-optical dyes as probes of heart 

excitability 
P01HL-I8208-04 0005 Center for the study of blood cell 

Theology - RBC detormability and capillary flow 

interrelations (human, mice) 
ROlHL-18527-03 Subcellular response of heart to 

functional overload (hamsters, rats) 
POlHL-18575-03 0001 Mechanisms of vascular changes 

in hypertension Arteries and resistance vessels in 

hypertension (pigs, rats) 
P01HL18708-03 0004 Oxygen, energy and contractility in 

cardiac tissue - Structural-functional studies on 

sarcoplasmic reticulum (rabbits) 
P01HL18708-03 0005 Oxygen, energy and contractility in 

cardiac tissue Cytosolic calcium homeostasis and 

bioenergetics of cardiac tissue (animals) 
POlHL-18708-03 0007 Oxygen, energy and contractility in 

cardiac tissue Surfaces, energy requirements, and 

contractile proteins of cardiac cell in vitro 
R01HL18711-03 Electrophysiology of heart cells (rats, 

chicks) 
ROlHL-18937-03 Cyclic nucleotides and calcium In 

platelets (human) 
ROIHL 1902703 Calcium and cyclic AMP In causation of 

hypertension (rats) 
R01HLI9044-03 Effect of drugs on development of 

cardiac failure (cats) 
ROlHL-1907603 Vagal control of heart rate -A biophysical 

model (rabbits) 
ROlHL-19082-01 Hypoxia-induced relaxation of vascular 

smooth muscle 
POlHL-19242-02 0003 Study of vascular smooth muscle - 

Vasoactive metabolites from vascular muscle and 

parenchymal tissue (animal) 
P01HL19242-02 0009 Study of vascular smooth muscle - 

Electrophysiology of vascular smooth muscle (rats, chick 

embryo) 
ROlHL-19461-03 Myocardial energetics in hypertrophy and 

heart failure (rabbits) 
RClHL-19485-03 Calcium uptake by normal and failed 

cardiac ATPase (dogs) 
POlHL-1973702 0002 Cellular and molecular aspects of 

respiratory physiology - Airway smooth muscle in health 

and disease (human, animals) 
POlHL-20592-02 0001 Cell biology of cardiac and 

skeletal muscle - Molecular mechanism of muscle 

contraction (animals) 
POlHL-20592-02 0003 Cell biology of cardiac and 

skeletal muscle - Cellular magnesium and anion activities 

in ion-specific microelectrodes (frogs) 
ROlHL-2061002 Nerve growth factor and obstructive 

cardiomyopathy (dogs) 
ROlHL-21030'01 Calcium regulation and hypertension 

(rats) 
R01HL-2I038-01 Electrically Induced cardiac EM- 

histochemical changes (animals) 
ROlHL-21 182-02 Active tension and shortening In cardiac 

hypertrophy (rabbits) 
R23HL-2121301 A model for calcium homeostasis in 

excitable tissue (marine worms) 
R23HL-21262-02 Sodium-calcium interactions in 

mammalian myocardium (rabbits, cats} 
ROlHL-21314-02 Respiratory tract secretion of ions, water 

and mucus (human, dogs) 
R23HL-21325-02 Sarcomere kinematics in cardiac 

contraction (rats, rabbits) 
ROlHL-2146901 Active transport and effect of CAOO in 

sickle cell (human) 
ROlHL-2181202 Actions of drugs and ions on cardiac 

membranes (rabbits, guinea pigs) 
ROIHL 21850-01 Calcium transport in the hypertrophied 

myocardium (rats, animals) 
ROlHL-2199501 Protein phosphorylation and adrenergic 

effects 
ROlHL'22135-01 Control of calcium fluxes across cardiac 

membranes (dogs, rabbits, guinea pigs) 
ROlHL-2217001 Factors influencing transmission at 

adrenergic synpases 
ROlHL-22264-01 Regulation of contraction in vascular 

smooth muscle (dogs) 
ROlHL-22269-01 Excitation-contraction coupling in 

enlarged hearts (rabbits) 
ROlHL-2235401 Alpha-adrenergic effects on heart 

metabolism (rats) 



Bronchial mucus production in organ 



ROlHL-22444-01 

culture (human) 
ROlHL-22558-01 pH effect in heart cells -Influence of 
cardiac drugs (tissue culture, rats) 
M POlHL-22619-01 Cellular mechanisms of heart failure 
*• POlHL-22619-01 0002 Cellular mechanisms of heart 
failure - Structure of sodium, potassium-adenoslne 
triphosphatase (lambs, dogs) 
** POlHL-22619-01 0009 Cellular mechanisms of heart 
failure - Sarcoplasmic reticulum In cardiac, skeletal and 
smooth muscle (rabbits, dogs) 
POlHL-22619-01 0010 Cellular mechanisms of heart 
failure - Mitochondria in heart and smooth muscle (rabbits, 
rats, dogs) 
ROlHL-22685-01 Drugs and excitation-contraction coupling 
in heart (animals) 
** ROlHL-22813-01 Palmitylcarnitlne inhibition of ion pumps 
in ischemia (dogs) 
ROlHL-22828-01 Adenosine and catecholamine interaction 

in the heart (rats) 
ROlHL-23128-01 Cardiac contractility-Ischemia and 

hypoxia (rabbits, rats) 
ROIHL 2314201 Mechanisms of membrane injury In 

myocardial ischemia (dog) 
ROIHL 23153-01 Mechanisms of altered CA20 transport in 
ischemic heart (dog, rabbit) 
** ROlHL-23161-01 0002 Biology of myocardial ischemia - 
Palmitylcarnitlne inhibition of ion pumps in myocardial 
ischemia (dog, sheep) 
** ROlHL-2320001 Isolation of CA binding proteins from 
erythrocytes (human) 

BIOLOGICAL TRANSPORT, ACTIVE TRANSPORT, 
ION PUMPS, CHLORIDE PUMP 

POlHL-12157-11 0060 Functions and mechanisms of cell 

membrane ion transport - Ion transport and electrical 

properties of giant-celled alga 
ROlHL-13256-08 Ammo acid transport by red cell 

membranes (pigeons) 
P01HL-14388-07 0167 Regulation of the circulation in 

pathological states • Increased reactivity of artery vascular 

muscle in spontaneously hypertensive rat 
POlHL-14388-07 0168 Regulation of the circulation In 

pathological states - Ionic basis of depolarization (rats. 



tissue culture) 
POlHL-14388-07 0179 
pathological states - 



Regulation of the circulation In 
Cultured muscle cells and their cross- 
innervation in vitro (rats, sheep) 
** POlHL-14388-07 0191 Regulation of the circulation in 
pathological states - Regulation of chloride transport in 
epithelial membranes (turtles) 
ROIHL 18053-03 Intracellular ionic activities In heart 
muscle (frogs) 
** ROIHL 20365-03 Molecular mechanisms of anion transport 
POIHL 20592-02 0003 Cell biology of cardiac and 
skeletal muscle - Cellular magnesium and anion activities 
in ion-specific microelectrodes (frogs) 
" POlHL-2059202 0005 Cell biology of cardiac and 
skeletal muscle - Quantitative voltage studies 
ROlHL-21 136-02 Ion activities and transport in cardiac 

muscle cells (sheep) 
ROlHL-21314-02 Respiratory tract secretion of ions, water 
and mucus (human, dogs) 

BIOLOGICAL TRANSPORT, ACTIVE TRANSPORT, 
ION PUMPS, HYDROGEN PUMP 

** ROlHL-12774-08 Ionic coupling in activation of cardiac 
muscle (frogs, guinea pigs) 

BIOLOGICAL TRANSPORT, ACTIVE TRANSPORT, 
ION PUMPS, POTASSIUM PUMP 

ROlHL-04457-20 Cellular aspects of active transport (fish, 

rabbits, anurans, turtles) 
ROlHL-08508-15 Cardiac conductivity and automaticity 

(human, dogs, rabbits) 
P01HL-08e82-lS 0036 Regulation of the cardiovascular 

system - Electrolyte transport in myocardium with 

hemorrhagic shock (rats) 
ROlHL-09906-13 0023 Membrane transport processes in 

red blood cells - Cation and anion movements in two sub- 
groups of dog erythrocytes 
** ROlHL-09906-13 0025 Membrane transport processes in 

red blood cells - Mechanism of propranolol induced Ca- 

dependent K efflux from human RBCs 
POIHL 12157-11 0054 Functions and mechanisms of cell 

membrane ion transport - Simulation of electrogenic ion 

transport in cardiac muscle 
POlHL-12738-10 0080 Physiologic pharmacology and its 

clinical applications - Electrophysiology of cardiac muscle 

in the mitral valve (monkeys) 
POlHL-1273810 0110 Physiologic pharmacology and its 

clinical applications - Physiology and pharmacology of 

arrhythmias (dogs) 
ROlHL-12990-09 Control of antidiuretic hormone secretion 

and metabolism (dogs, rats, rabbits) 
POlHL-14388-07 0152 Regulation of the circulation In 

pathological states - Ion flux alterations in caudal artery in 



SHR 

POlHL-14388-07 0167 
pathological states 



Regulation of the circulation in 
Increased reactivity of artery vascular 



muscle in spontaneously hypertensive rat 



BIO 

POlHL-14388-07 0168 Regulation of the circulation in 

pathological states - Ionic basis of depolarization (rats, 

tissue culture) 
POlHL-14414-07 0016 Environmental influences on 

cardiorespiratory and cellular functions ■ Effects of 

pressure on membrane and cellular function (human, 

rabbits) 
ROIHL 14775-08 Mechanisms of drug action in vascular 

smooth muscle (dog, rabbits) 
P01HL1519407 0004 Pathophysiology of 

cardiopulmonary dysfunction - Specialized electrophysiology 

fibers -Electrogenic basis of glycosides (mammals) 
ROIHL 16052-05 Cardiac glycosides -Mechanism of 

inotropic action (dogs) 
ROlHL-16135-05 Mechanisms of cardiac autorhythmicity 

(dogs, bats) 
ROlHL-16152-06 Electrophysiology of neonatal to adult 

heart (cats, frogs, guinea pigs) 
ROlHL'17452-04 Depolarization induced cardiac 

automaticity (human, animals) 
ROlHL-18943-03 Contractile activity of single cardiac cells 
ROIHL- 19082-01 Hypoxia-induced relaxation of vascular 

smooth muscle 
POlHL-19242-02 0003 Study of vascular smooth muscle • 

Vasoactive metabolites from vascular muscle and 

parenchymal tissue (animal) 
R23HL'I9601'01 Cardiac response to chronic metabolic 

acidosis (rats) 
ROlHL-20 153-02 Intracellular pH and myocardial 

electropharmacology (dogs, guinea pigs) 
ROIHL 20558-02 Cardiac electrophysiology-Effects of Ions 

and drugs 
" POlHL-2059202 0006 Cell biology of cardiac and 

skeletal muscle - Permeability and ultrastructure of cardiac 

nexuses (rabbits, cattle, rats) 
POlHL-21016-02 0008 Sickle cell anemia and other 

hemoglobinopathies - The clinical variations of sickle cell 

anemia 
ROlHL-21136-02 Ion act.. .ties and transport In cardiac 

muscle cells (sheep) 
R01HL-2n79-01 Volume regulation-Role of the membrane 

potential (amphiuma) 
ROlHL-21294-02 Voltage clamp of isolated cardiac 

Purkinje cells (dogs) 
ROlHL-22568-01 pH effect in heart cells-Influence of 

cardiac drugs (tissue culture, rats) 
R23HL-22775-01 Muscarinic receptors in the developing 

heart (chick embryo) 
** ROlHL-23 115-01 Regulation of active sodium transport 

(frogs, rats) 

BIOLOGICAL TRANSPORT, ACTIVE TRANSPORT, 
ION PUMPS, SODIUM PUMP 

ROlHL-04457-20 Cellular aspects of active transport (fisb, 

rabbits, anurans. turtles) 
** P01HL0628518 0193 Cardiovascular-respiratory 

physiology and biochemistry - Hormonal regulation of 

sodium transport -Aldosterone (rats, toads) 
POlHL-06285-18 0194 Cardiovascular-respiratory 

physiology and biochemistry - Hormonal regulation of 

sodium transport -RNA synthesis (rats, toads) 
** POlHL-0628518 0195 Cardiovascular-respiratory 

physiology and biochemistry - Thyroid thermogenesis and 

sodium transport (rats) 
** P01HL06285-18 0196 Cardiovascular-respiratory 

physiology and biochemistry - Hormonal regulation of 

sodium transport -Epithelial cell membranes (toads) 
** POlHL-06285-18 0197 Cardiovascular-respiratory 

physiology and biochemistry - Micropertusion and 

micropuncture of renal tubules (hamsters, desert rats) 
** POlHL-06285-18 0199 Cardiovascular-respiratory 

physiology and biochemistry - Renal tubular reabsorption of 

sodium chloride (hamsters, rabbits) 
** POlHL-06285-18 0200 Cardiovascular-respiratory 

physiology and biochemistry - Medullary counter-current 

system (animals) 
** POlHL-06308-18 0035 Mechanisms and therapy of 

circulatory disease - Mechanisms for electrophysiological 

changes in myocardial infarction (dogs) 
POlHL-06664-17 0037 Cardiopulmonary function in 

remediable vascular disease - Salt and water balance of 

cells and tissues (rabbits) 
** POlHL-06664-17 0039 Cardiopulmonary function in 

remediable vascular disease - Transepithelial active 

transport and cell volume regulation (frogs) 
** P01HL06664-17 0040 Cardiopulmonary function in 

remediable vascular disease - The coupling of ion transport 

to metabolism (toads) 
** POlHL-07896-15 0029 Environmental biomedical research 

program - Oxygen-helium diving resulting in high pressure 

nervous syndrome (human, animals) 
** POlHL-07896-15 0030 Environmental biomedical research 

program - Narcosis caused by inert gases at raised 

pressures (human, animals) 
POlHL-08682-15 0036 Regulation of the cardiovascular 

system - Electrolyte transport in myocardium with 

hemorrhagic shock (rats) 
ROlHL-08893-14 Structure and function of membrane 

proteins (human) 
ROlHL-09906-13 0023 Membrane transport processes in 

red blood cells - Cation and anion movements in two sub- 
groups of dog erythrocytes 

(contd) 



'Excludes routine methodology OR c(>vers only general projects which preclude indexing at the specific level. 
"Oriented significantly to above subject. 



M Grant has subprojects describing specific research aspects 
See Appendix for investigator's name and grant number 



■'y.y3»mm3ur^K^^ji-jr '. 



BIO 



27 



BIO 



Regulation of the circulation in 
Renal tubular secretion of magnesium 



ROINl 1089' I? Ettacti o( hormonal on cardiac 

•lactiogenesis (rabbits* guinea pigs, dogs) 
" ROIHL 10914 10 Ranal sodium transport in iiperimental 

aldostaionism (dogs) 
POIHL lUbl 12 0001 Cellular and molecular 

mechanisms ot myocardial function Ionic control of 

myocaidial contiactility (animals) 
POIHL ll3bl I? OOIS Cellulai and molecular 

mechanisms ol myocardial function Itfects of hypoxia 

and ischemia on ion eichange and heart function (idbbits) 
** POlHt 12157 II 0033 functions and mechanisms of cell 

membrane ion transport Immunology aspects ol active 

Na K liansporl in sheep led cell (also human, mice) 
POlffl 12157 11 00S4 Functions and mechanisms ot cell 

membiane ion transport Simulation of electrogenic ion 

transport in cardiac muscle 
POlltl 12738 10 0044 Physiologic pharmacology and its 

clinical applications Cardioactive drugs and 

electrophysiological properties ol cardiac cells (sheep) 
POIHL 12738 10 0136 Physiologic pharmacology and its 

clinical applications 
ROIHL 12990 09 Control of antidiuretic hormone secretion 

and metabolism (dogs. rats, rabbits) 
ROIHL 132S6'08 Ammo acid transport by red cell 

membranes (pigeons) 
POIHL 1438807 0152 Regulation of the circulation in 

pathological states Ion flux alterations in caudal artery in 

SHR 
POIHL 1438807 0192 

pathological states 

(rats) 
P01HL1441407 0016 Environmental influences on 

cardiorespiratory and cellular functions Effects ol 

pressure on membrane and cellular function (human, 

rabbits) 
ROIHL 14899 07 Mechanism and prevention of cardiac 

arrtiythmias (dogs) 
P50HL'1S061'07 0005 Response of lung to injury - Airway 

smooth muscle in health and disease (dogs, guinea pigs) 
R01HL'ie052'05 Cardiac glycosides-Mechanism of 

inotropic action (dogs) 
•• P60HL1 726904 0017 National heart and blood vessel 

research and demonstration center - Cell membrane (dogs. 

rabbits) 
P60HL'1726904 0018 National heart and blood vessel 

research and demonstration center - Mitochondria and 

energetics (rabbits, dogs) 
P60HL-17269'04 0022 National heart and blood vessel 

research and demonstration center - Medicinal chemistry 

(rabbit, dog. guinea pig) 
ROIHL 17702-04 Electro-optical dyes as probes of heart 

excitability 
POlHL'l 787 1-04 0013 Kidney, sodium, cardiac output. 

arterioles and hypertension - Perfusion pressure and renal 

sodium excretion (rats) 
** R01HL-I8 185-04 Cardiac glycosides and diuretics -Role of 

NaO pump (dogs) 
ROlHL-18943-03 Contractile activity of single cardiac cells 
R01HL-19216-03 Characterization of cardiac pacemaker 

activity (cat. dog. rabbit) 
R01HL'19320-03 Angiotensin neuropharmacology- 

Relatlonship to sodium 
ROlHL-19366-03 Renal Starling forces in experimental 

conditions (rats, rabbits) 
ROlHL-19398-03 Regional conduction abnormalities and 

arrhythmias (dogs) 
R23HL-19601-01 Cardiac response to chronic metabolic 

acidosis (rats) 
ROlHL-20153-02 Intracellular pH and myocardial 

electropharmacology (dogs, guinea pigs) 
R01HL-2017e-02 Biochemistry and genetics of salt 

hypertension (rats) 
ROlHL-20558-02 Cardiac electrophysiology-Effects of ions 

and dr^gs 
POlHL-20581-01 0001 Vascular neuroeffector 

mechanisms in health and disease - Vascular neuroeffector 

mechanism (rabbits) 
ROlHL-21014-01 Mechanism of the inotropic action of 

cardiac glycosides 
ROlHL-21179-01 Volume regulation-Role of the membrane 

potential (amphiuma) 
ROlHL-21217-01 Ion and 5-hydroxytryptamine transport by 

platelets 
** R23HL-21262-02 Sodium-calcium interactions in 

mammalian myocardium (rabbits, cats) 
ROlHL-21314-02 Respiratory tract secretion of ions, water 

and mucus (human, dogs) 
** ROlHl-21342-02 Isolation and analysis of sodium channel 

from heart (frogs) 
ROlHL-21672-01 Antiarrhythmic drug action on VMAZ of 

cardiac cells 
ROlHL-21742-01 Frequency-dependent drug actions in 

cardiac muscle (rabbits) 
*• ROlHL-22239-01 The molecular basis of electrical 

excitability (chick embryos, rats) 
R23HL-22245-02 Functional characteristics of atrial 

receptors (rats) 
ROlHL-22264-01 Regulation of contraction in vascular 

smooth muscle (dogs) 
ROlHL-22568-01 pH effect in heart cells-Influence of 

cardiac drugs (tissue culture, rats) 



ROIHL 22685 01 Diugs and excitation contraction coupling 
II) heart (animals) 
** ROIHI 2281301 Pilmitylcainitine inhibition ol ion pumps 
in ischemia (dogs) 
R23Ht 27882 01 Modulation hy disease of ettecl of 
turosemide in man 
** ROIHL 231 15 01 Regulation ol active sodium transport 
(liogs. rats) 

BIOLOGICAL TRANSPORT, ACTIVE TRANSPORT, 
ION PUMPS, SODIUM-POTASSIUM PUMP 

ROIHL 01974 24 Ion pump in the erythrocyte (rabbits, 

guinea pigs) 
POIHL 06308 18 0025 Mechanisms and therapy of 

circulatory disease Subcellular calcium pools in the 
genesis of arrhythmias (dogs) 
POIHL 063 14 17 0055 Immunologic mechanisms in 

cardiovascular disease Genetics and cell biology 
POIHL 06664 17 0036 Cardiopulmonary function in 

remediable vascular disease In vitro studies on the 
mechanism of ischemic damage to cells (rabbits) 
POIHL 07896 15 0032 Environmental biomedical research 

program Fluorometry study of brain exposed to hyperbaric 
oxygen (dogs, cats) 
ROIHL 09234 13 Ammo acids of contractile proteins ol 
failing hearts (dogs, hamsters) 
** ROIHL 09906 13 0018 Membrane transport processes in 
red blood cells Rapid photolytic release of ATP from a 
protected analog NaK pump of R6C ghosts 
*• ROIHL 09921 13 Mechanisms related to congestive heart 

failure (dogs, human, rat) 
•* P01HLn35112 0009 Cellular and molecular 

mechanisms of myocardial function Myocardial membrane 
surface coat (rats, rabbits) 
** POlHL-11351-12 0010 Cellular and molecular 

mechanisms of myocardial function Basic ionic exchange 
studies (rats) 
** POlHL-11351 12 0011 Cellular and molecular 
mechanisms of myocardial function - Comparative 
contractile tissue studies (animals) 
** R01HL12774-08 Ionic coupling in activation of cardiac 
muscle (frogs, guinea pigs) 
R01HL-I2839-09 Flow, transport and membrane 

phenomena in blood (human) 
ROlHL-12990-09 Control of antidiuretic hormone secretion 

and metabolism (dogs. rats, rabbits) 
ROlHL-13375-09 Cellular potential changes causing 

cardiac arrhythmias (dogs) 
POlHL-14388-07 0167 Regulation of the circulation in 
pathological states - Increased reactivity of artery vascular 
muscle in spontaneously hypertensive rat 
POlHL-14388-07 0168 Regulation of the circulation in 
pathological states - Ionic basis of depolarization (rats. 



tissue culture) 
POlHL-14388-07 0179 
pathological states 



Regulation of the circulation in 
Cultured muscle cells and their cross- 

innervation in vitro (rats, sheep) 
POlHL-14388-07 0223 Regulation of the circulation in 

pathological states - Kallikrein-kinin system in hypertension 

(rats) 
R01HL-U526-07 Oral contraceptives and hypertension 

(rats) 
POlHL-14985-07 0012 Adaptation to hypoxia - Direct 

effect of hypoxia on pulmonary vascular smooth muscle 

(rats, dogs) 
R0IHL-1SS22-06 Influence of mannitol on ischemia 

cardiac muscle (dogs. cats, rats) 
POlHL-15835-06 0018 Study of muscles related to heart 

disease - Pharmacology of excitation coupling in muscle 

(frog, barnacles) 
R01HL-ie3 18-21 Biochemistry and pharmacology of Na-K 

transport 
ROlHL-16454-03 Vascular muscle reactivity in 

hypertension (human, rats) 
ROIHL 16549-04 Cardiotonic steroid-NaK ATPase 

interactions (cattle) 
ROlHL-16567-04 Differentiation of the heart-cell 

membrane (mice, chick) 
ROlHL-17451-05 Digitalis effects on cardiac automaticity 

mechanisms 
ROlHL-17555-05 Distribution and metabolism of labeled 

digitaloids (dogs, guinea pigs) 
R01HL-17796-04 Importance of aminosugars in digitalis 

activity (cats, rabbits) 
R01HL-180S3-03 Intracellular ionic activities in heart 

muscle (frogs) 
POlHL-18575-03 0001 Mechanisms of vascular changes 

in hypertension - Arteries and resistance vessels in 

hypertension (pigs, rats) 
ROlHL-18598-03 Role of Na, K-ATPase inhibition on 

digitalis action 
ROlHL-187 11-03 Electrophysiology of heart cells (rats. 

chicks) 
ROlHL-18798-04 0001 Nervous and ionic factors in 

sudden cardiac death - Potassium loss during myocardial 

ischemia (rabbits) 
ROlHL-190 76-03 Vagal control of heart rate-A biophysical 

model (rabbits) 
R01HL-19129-04 Cardiac glycosides-Mechanisms of 

cellular actions 
POlHL-19737-02 0002 Cellular and molecular aspects of 

respiratory physiology - Airway smooth muscle in health 

and disease (human, animals) 



ROIHL 19933 07 Membrane and led oil dytlunrlion m 
hemolytic annfnia (human) 
" ROIHI 20762 02 Cardiac (lycotidet and the machaniin 
ol the lodium polattium pump 
POIHI 7059? 07 0005 Cell biology of cardiac and 

skeletal muscle Quantitative voltage itudwt 
** ROIHL 70/11 01 Structure function ralalionthipt in rtd 
cell NA K pumps (goats) 
P60HL 70985 01 0004 Northern California sickle cell 

center Characlen/alion ol irreversibhr sickled cells 
(human) 
ROIHI 71014 01 Mechanism of the inotropic action of 

cardiac ghfcosides 
ROIHL 21136 02 Ion activities and transport in cardiac 
muscle cells (sheep) 
*• R23HL21I96 02 Digitalis induced arrhythmia and NAO RO 
atpase activity (dogs) 
RCIHL 21525 02 Effect of cations, anions and water upon 

blood vessels (dogs, rats) 
ROIHL 21995 01 Protein phosphorylation and adrenergic 
effects 
M POIHL 2261901 Cellular mechanisms of heart failure 
•* POIHL 2261901 0001 Cellular mechanisms of heart 

failure Cell membrane isolation and reconstitution (dogs, 
lambs) 
" POIHL 22619-01 0002 Cellular mechanisms of heart 
failure Structure of sodium, potassium adenosine 
triphosphatase (lambs, dogs) 
** POIHL 22619 01 0003 Cellular mechanisms of heart 
failure Digitalis induced inotropy in myocardial ischemia 
heart failure (animals) 
** POIHL 22619-01 0004 Cellular mechanisms of heart 
failure Mechanism of action of Na. K-ATPase (sheep, 
cattle) 
ROIHL 22951-01 Studies on the affect of vitamin E on 
platelets (human, rats) 
** ROIHL 2316101 0002 Biology of myocardial ischemia - 
Palmitylcarnitine inhibition of ion pumps in myocardial 
ischemia (dog. sheep) 
ROIHL 2331201 Hemodynamics and vasoactivity in renal 
hypertension (human, dogs) 
** ROlHL-23600-01 Ions, water, and hypertension (human, 
dogs, rats) 

BIOLOGICAL TRANSPORT, ACTIVE TRANSPORT, 
PINOCYTOSIS 

SEE ALSO CELL INGESTION. PHAGOCYTOSIS 
R01HL04512 19 Ultrastructural studies of capillary 

permeability (rats, mice) 
P01HL-0880S-15 0048 Regulation of ventilation and 

pulmonary circulation - Permeability of alveolo-Capillary 

membrane in normal pulmonary hypertensive lung 
ROlHL-10642-18 Plasma cholesterol metabolism (human, 

macaca) 
ROlHL-11154-12 

(human) 
ROlHL-12421-10 

(dogs, baboons) 
P50HL-14230-07 0092 A/S SCOR-Lipids. atherosclerosis 

and thrombosis - Tissue lipids-Cell culture studies 

(human) 
P50HL-14237-07 0002 Support for arteriosclerosis center 

- Interactions of lipoprotein particles with vascular surtace 

(human, rat) 
** ROlHL-16666-05 Micropinocytosis in isolated capillary 

endothelium 
P01HL-16748-05 0001 Cellular and immunological basis 

of pulmonary diseases - Mechanisms of alveolar 

macrophage function and dysfunction (human, rabbits) 
ROlHL-18010-04 Capillary transport of large molecules 

(dogs, sheep) 
ROlHL-19721-03 Lung inflammation-Lysosomal proteases 

and liposomes (human, rabbits) 
POlHL-20948-02 0002 Molecular basis of cholesterol 

metabolism - LDL pathway in cell lines with informative 

properties other than fibroblasts 
ROlHL-21120-02 Membrane dynamics in alveolar 

macrophages (rabbits) 
" R23HL-21411-02 Control of extracellular lysosomal 

hydrolase levels (rats) 
R01HL-217S6-11 Vascular disease-Cytochemistry and 

ultrastructure (human, rats. mice, hamsters) 
ROlHL-22170-01 Factors influencing transmission at 

adrenergic synpases 
** ROlHL-22463-02 Pinocytotic vesicles and pulmonary 

edema (rats) 
ROlHL-22924-01 The airway mucosal barrier (guinea pigs) 

BIOLOGICAL TRANSPORT, FLUID EXCHANGE 
AND TRANSPORT 

SEE ALSO BIOLOGICAL TRANSPORT. PASSIVE TRANSPORT. 

DIFFUSION 
SEE ALSO BIOLOGICAL TRANSPORT. PASSIVE TRANSPORT. 

OSMOSIS 
SEE ALSO BLOOD OSMOTIC PRESSURE 
SEE ALSO BODY FLUID BAUNCE THERAPY 
SEE ALSO CELL FLUIDS. OSMOTIC PRESSURE 
" ROlHL-09921-13 Mechanisms related to congestive heart 

failure (dogs, human, rat) 
" P50HL-14218-07 0017 Pulmonary SCOR-Newborn lung 

center - Transvascular fluid exchange, vasoactive mediators 
in RDS (sheep, cat) 

(contd) 



Blood group antigens and antibodies 
Pathophysiology of circulatory shock 



'Excludes nwtine methodotogy OR covers only general projects which preclude indexing at the specific level. 
"Oriented significantly to above subject. 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



BIO 

** ROlHL-15593-05 Prolonged extracorporeal cardiopulmonary 

support (ratso sheep, rabbits) 
P50HL19153-02 0004 SCOR-Pulmonary edemas -Eitology, 

pathogenesis - Physical mechanisms In lung transvascular 

transport-Math models (sheep) 
M P50HL 19155-02 Pathophysiology of pulmonary edema 
P50HL-19155-02 0001 Pathophysiology of pulmonary 

edema - Pulmonary edema study unit (human, dog) 
** P50HL19155-02 0004 Pathophysiology of pulmonary 

edema - Physical and chemical effects of multiple 

pulmonary emboli (sheep) 
** P50HL-19185-02 0004 Pulmonary SCOR -Neonatal 

respiratory distress syndromes - Fluid and protein transport 

in fetal and newborn lung (sheep, rabbits) 
** ROlHL-21314-02 Respiratory tract secretion of ions, water 

and mucus (human, dogs) 
** ROlHL-21376-02 Blood-gas barrier solute and water 

transport (rabbits) 
R01HL-2180001 Angiotensin eftects on water Intake and 

excretion 
** ROlHL-22444-01 Bronchial mucus production in organ 

culture (human) 
" RO'HL-22569-02 Intestinal secretion-Capillary and tissue 

forces (dogs, cats) 

BIOLOGICAL TRANSPORT, ION EXCHANGE AND 
TRANSPORT 

R01HL018I3-25 Regulation of metabolism by drugs and 
hormones (rats) 
** ROlHL-02835 21 Renal transport carrier for organic 
compounds (dogs, rats) 
R01HL04457-20 Cellular aspects of active transport (fish, 

rabbits, anurans, turtles) 
POlHL-06285-18 0189 Cardiovascular-respiratory 
physiology and biochemistry - Mucociliary clearance (cats, 
dogs) 
P01HL0628518 0194 Cardiovascular-respiratory 
physiology and biochemistry ■ Hormonal regulation of 
sodium transport-RNA synthesis (rats, toads) 
POlHL-0628518 0197 Cardiovascular-respiratory 
physiology and biochemistry - Microperfusion and 
micropuncture of renal tubules (hamsters, desert rats) 
POlHL-06285-18 0198 Cardiovascular-respiratory 
physiology and biochemistry • Renal tubular secretion of 
hydrogen ion (animals) 
POlHL-06285-18 0200 Cardiovascular-respiratory 
physiology and biochemistry - Medullary counter-current 
system (animals) 
POlHL-0628518 0211 Cardiovascular-respiratory 
physiology and biochemistry ■ Purple membrane of 
Halobacteria 
POlHl-06314-17 0047 Immunologic mechanisms in 
cardiovascular disease - Role of intravascular coagulation 
(human, animals) 
POlHL-06664-17 0040 Cardiopulmonary function in 
remediable vascular disease - The coupling of ion transport 
to metabolism (toads) 
POlHL-0789615 0029 Environmental biomedical research 
program ■ Oxygen-helium diving resulting in high pressure 
nervous syndrome (human, animals) 
" P01HL08682-15 0036 Regulation of the cardiovascular 
system - Electrolyte transport in myocardium with 
hemorrhagic shock (rats) 
ROlHL-08977-14 Quantitation of flow and solute flux in 
microvessels (cats, rats) 
** ROlHL-0936414 Ion transport by heart mitochondria 

(cattle, rat, rabbit) 
•* ROlHL-09906-13 0020 Membrane transport processes in 
red blood cells - Calibration of a fluorescent probe for 
erythrocytes 
** ROlHL-09906-13 0022 Membrane transport processes in 
red blood cells - Anion transport in dog and cat red cells 
ROlHL-09906-13 0023 Membrane transport processes in 
red blood cells - Cation and anion movements in two sub- 
groups of dog erythrocytes 
" ROlHL-09906-13 0024 Membrane transport processes in 
red blood cells - Inhibition of sulfate transport in human 
RBCs by isothiocyanic acid esters 
** ROlHL-10182-13 Circulatory function and electrolytic 
metabolism (dogs, human) 
POIHL-10436-13 0002 A multidisciplinary study of 
congenital heart disease - Myocardial performance, 
metabolism and ultrastructure (human, cats, rats) 
** ROlHL-10503-13 Cardiac ion transport and ultrastructure 
(rats, guinea pigs, rabbits) 
ROlHL-10914-10 Renal sodium transport in experimental 
aldosteronism (dogs) 
M POlHL-11351-12 Cellular and molecular mechanisms of 

myocardial function 
•• POlHL-1 135112 0001 Cellular and molecular 

mechanisms of myocardial function - Ionic control of 
myocardial contractility (animals) 
*• P01HL-1135M2 0002 Cellular and molecular 

mechanisms of myocardial function - Eftects of hypoxia 
and ischemia on ionic exchange (rats, rabbits) 
** POlHL-1 1351-12 0009 Cellular and molecular 

mechanisms of myocardial function - Myocardial membrane 
surface coat (rats, rabbits) 
*• POlHL-11351-12 0011 Cellular and molecular 
mechanisms of myocardial function - Comparative 
contractile tissue studies (animals) 



28 

" POlHL-11351-12 0013 Cellular and molecular 

mechanisms of myocardial function - Ion exchange in the 
perfused septum high-resolution technique (rabbits rats) 
** P01HL-1135M2 0015 Cellular and molecular 

mechanisms of myocardial function - Eftects of hypoxia 
and ischemia on ion exchange and heart function (rabbits) 
POlHL-11351-12 0020 Cellular and molecular 
mechanisms of myocardial function - Electrophysiology of 
cultured heart cells 
POlHL-1 1678-11 0063 Cardiovascular dynamics and their 
control - Renin-angiotensin system-Control of renal 
hemodynamics, electrolyte excretion 
M P01HL-I215711 Functions and mechanisms of cell 

membrane ion transport 
** POlHL-12157-11 0049 Functions and mechanisms of cell 
membrane ion transport - Ouabain-insensitive cation 
transport in duck red cells 
** POIHL-12157-11 0060 Functions and mechanisms of cell 
membrane ion transport - Ion transport and electrical 
properties of giant-celled aiga 
ROlHL-12990-09 Control of antidiuretic hormone secretion 

and metabolism (dogs, rats, rabbits) 
R01HLI2997-07 Myocardial defects induced by potassium 

depletion (human, rats, cats) 
ROlHL-1325608 Ammo acid transport by red cell 

membranes (pigeons) 
ROlHL-13349-06 Analysis of activation process in heart 
muscle (guinea pigs, rabbits, human) 
** R01HL-13567-06 Ion transport across cell membranes 
(human) 
ROlHL-13636-08 Eftects of pharmacologic agents on heart 

metabolism (human, rodents) 
R01HL-136G6-06 Pharmacology of genesis of cardiac 
rhythmicity (rats, cats) 
** ROlHL-14133-08 Intrarenal regulation of sodium 
reabsorption (dogs, hamsters, rats) 
ROlHL-14148-07 0008 The regional circulations - Renal 

circulation in hypertensive patients (also dogs) 
P50HL-14212-07 0013 Correlated studies of pulmonary 
fibrosis ■ Mechanism of beryllium pathogenicity in the lung 
(human, rabbit, guinea pig) 
** POlHL-14388-07 0168 Regulation of the circulation in 
pathological states - Ionic basis of depolarization (rats, 
tissue culture) 
POlHL-14388-07 0172 Regulation of the circulation in 
pathological states - cAMP-dependent protein kinase from 
heart and vascular smooth muscle (guinea pigs) 
POlHL-14388-07 0175 Regulation of the circulation in 
pathological states ■ Functional studies of selected proteins 
from cardiac muscle 
P01HL14388-07 0179 Regulation of the circulation in 
pathological states - Cultured muscle cells and their cross- 
innervation in vitro (rats, sheep) 
POlHL-1438807 0191 Regulation of the circulation in 
pathological states - Regulation of chloride transport in 
epithelial membranes (turtles) 
POlHL-1438807 0192 Regulation of the circulation in 
pathological states - Renal tubular secretion of magnesium 
(rats) 
P01HL14414-07 0016 Environmental influences on 
cardiorespiratory and cellular functions - Effects of 
pressure on membrane and cellular function (human, 
rabbits) 
ROlHL-1448308 Energy conservation in heart 

mitochondria (cattle, E coll, human) 
ROlHL-14523-07 Generation and regulation of force in 

smooth muscle (animals) 
ROlHL-14720-08 Factors governing the renal excretion of 

acid (humans, rats) 
ROlHL-14775-08 Mechanisms of drug action in vascular 

smooth muscle (dog, rabbits) 
ROlHL-14820-07 Factors aftecting physiology of biological 

membranes (human) 
P60HL-15I57-07 0009 Comprehensive center for sickle 
cell disease - Red cell membrane alterations during 
sickling (human) 
P60HL-15I57-07 0018 Comprehensive center for sickle 
cell disease • Red blood cell membrane physiology in sickle 
cell anemia (human) 
POlHL-15194-07 0004 Pathophysiology of 
cardiopulmonary dysfunction • Specialized electrophysiology 
fibers-Electrogenic basis of glycosides (mammals) 
ROlHL-15668-06 Extracorporeal respiratory gas exchange- 

A new approach (dogs) 
R01HL-15G92-07 Force and speed in skeletal and cardiac 

muscle 
ROlHL-15813-05 Cardiac anoxia -Protective eftect of 

carbohydrate (dogs) 
POlHL-15835-06 0013 Study of muscles related to heart 
disease • Cardiac bioenergetics (rats) 
** POlHL-15835-06 0018 Study of muscles related to heart 
disease - Pharmacology of excitation coupling in muscle 
(frog, barnacles) 
POIHL-15835-06 0019 Study of muscles related to heart 
disease - Vascular smooth muscle-Electron microscopy, 
excitation contraction (animal) 
P0IHL-15835-0G 0023 Study of muscles related to heart 
disease - Cellular basis of the Frank-Starling curve (frogs, 
rats) 
** ROlHL-15852-06 Vascular ion transport and hypertensive 
mechanisms 



'Excludes routine methodology OR covers only general proiecls which preclude indexing 
"Oriented significantly to above subject 



at the specific level 



M Grant has subproiects de scribing sped 
See Appendix for investigator's name and 



BIO 

P60HL15999-05 0014 Miami comprehensive sickle cell 
center - Biochemical and morphological parameters of 
sickle cells (human) 
ROlHL-15010-16 Cellular basis of cardiac contractility 
(frogs) 
M POlHL-16117-05 Ion movements and membranes in 

cardiovascular control 
** POlHL-16117-05 0003 Ion movements and membranes in 
cardiovascular control - Fast kinetic study of calcium 
membrane interactions 
POlHL-16117-05 0008 Ion movements and membranes in 
cardiovascular control • Arterial smooth muscle calcium 
fluxes and contractility (rabbits) 
ROlHL-16152-06 Electrophysiology of neonatal to adult 
heart (cats, frogs, guinea pigs) 
** ROlHL-16318-21 Biochemistry and pharmacology of Na-K 
transport 
ROlHL-16421-08 Determinants of RBC deformability and 

capillary flow (human, mice) 
ROlHL-16436-04 Role of calcium and thyroxine in heart 

function (rats) 
ROlHL-16454-03 Vascular muscle reactivity in 
hypertension (human, rats) 
** POIHL 16607-05 0001 Calcium ion and control of 
cardiovascular function - Bilayer lipid membranes, 
antibiotic probes, and SR function 
** R01HL-I6746-04 Design of ion-selective molecules 

POIHL-16833-04 0014 Hemoglobin and red cell system in 
hemoglobinopathies - Erythrocyte membrane damage in Hb 
SS disease (human) 
P60HL-17269-04 0022 National heart and blood vessel 
research and demonstration center - Medicinal chemistry 
(rabbit, dog, guinea pig) 
ROlHL-17411-04 Molecular studies of red blood cell 

spectrin (human) 
R01HL-I745I-05 Digitalis effects on cardiac automaticity 

mechanisms 
ROlHL-17452-04 Depolarization induced cardiac 

automaticity (human, animals) 
ROlHL-17571-03 Study of membrane permeability by NMR 

relaxation (human) 
P50HL-17648-04 0014 Study of ischemic heart disease ■ 
Antidysrhythmic drugs and mammalian cardiac Purkinje 
fibers (sheep, dog) 
P50HL 17669-04 0006 Ischemic heart disease center 
(SCOR) - Studies of hypoxic, acidotic and ischemic cardiac 
muscle (dogs) 
R01HL17702-04 Electro-optical dyes as probes of heart 

excitability 
POlHL-17871-04 0013 Kidney, sodium, cardiac output, 
arterioles and hypertension ■ Perfusion pressure and renal 
sodium excretion (rats) 
** R01HL-I7878-04 Structural studies of the human 
erythrocyte membrane 
ROlHL-18003-05 Digitalis-Mechanism and reversal studies 

(dog, sheep, duck, guinea pig, human) 
ROIHL-18032-03 Development of normal and myopathic 

mammalian heart (hamsters) 
ROlHL-18038 03 Structure and function of heart 
mitochondria (cattle) 
** ROlHL-18053-03 Intracellular ionic activities in heart 
muscle (frogs) 
ROlHL-1814804 Adrenal catecholamine secretion 
ROlHL-18199-03 Effects of ions on vascular reactivity 
ROlHL-18943-03 Contractile activity of single cardiac cells 
ROlHL-19008-02 Carbon dioxide diffusion in lung and 

muscle tissues (dogs) 
ROlHL-19012-03 Smooth muscle of resistance vessels in 
hypertension (rats) 
" ROlHL-19129-04 Cardiac glycosides-Mechanisms of 
cellular actions 
R01HL-19I38-03 Contractile activation of skinned cardiac 
cells (mammals) 
** ROlHL-19139-03 Dispersion of diffusible indicators in the 
body (human, cats, dogs) 
P50HL-19157-02 0001 Studies in cystic fibrosis and 

bronchiolitis - Laboratory core unit 
P50HL-19157-02 0007 Studies in cystic fibrosis and 

bronchiolitis - Analysis of cystic fibrosis factors (human) 
R23HL-19601-01 Cardiac response to chronic metabolic 

acidosis (rats) 
ROIHL-19639-02 Permeability transients of carriers, 

channels and heart 
R01HL-I9673-03 Surgical aspects of shock and hypoxia 

(dogs, monkeys, rats) 
ROlHL-19674-02 Electrolyte permeability of single 

capillaries (frogs) 
ROlHL-20153-02 Intracellular pH and myocardial 

electropharmacology (dogs, guinea pigs) 
ROlHL-20230-02 Analysis of the action potential of 

cardiac muscle (sheep) 
ROlHL-2036503 Molecular mechanisms of anion transport 
** ROlHL-20558-02 Cardiac electrophysiology -Effects of ions 

and drugs 
M POlHL-20592-02 Cell biology of cardiac and skeletal 
muscle 
POlHL-20592-02 0004 Cell biology of cardiac and 
skeletal muscle - Excitation, conduction and contraction - 
Modelling in Purkin/e fibers 
** POlHL-20592-02 0013 Cell biology of cardiac and 
skeletal muscle - Sarcoplasmic reticulum in skinned 
muscle cells (frogs) 

(coritdj 
fie research aspects 
grant number 



I 



BIO 



KOIHL ?0I\\ 01 Sttucluio lunclion idilionships (n red 

c«ll NAK pumps (lotitsl 
ROIHl ?0'?0 0? Myocirdial piotection duiint 

catdiopulmontty bypiss |do(s) 
ROIHl 20??S0? Mechanisms and cellulai lunclions ot lun 

tiansport 

Anesthetic induced myocjididl depirssion 



Cellular aspects ol luni iniury (rats. 



Ion and S hydroxytryptamine transport by 



ROIHl ?0?S4 02 

(rabbits) 
ROIHl ?08 78 0? 

rabbits) 
" P60HI 2098S 01 0004 Northern California sickle cell 

center Characteriiation at irreversibly sickled cells 

(human) 
** ROIHl 21136 02 Ion activities and transport m cardiac 

muscle cells (sheep) 
" R23HI 21150 02 Regulation ol airway mucous glands and 

Ion transport (dogs, ascaris) 
** ROIHl 2117901 Volume regulation Role o( the membrane 

potential (amphiuma) 
ROlHL-21195 02 Innervation ol the heart Acetylcholine 

receptors (trogs) 
•• R01HL2121701 

platelets 
ROIHL 2129402 Voltage clamp ol isolated cardiac 

Purkinie cells (dogs) 
** ROIHl 21314 02 Respiratory tract secretion of ions, water 

and mucus (human, dogs) 
ROIHl 21342 0? Isolation and analysis ol sodium channel 

trom heart (Irogs) 
ROlHl-2167001 Antiarrhythmic studies on 2substituted 

aminoindenes (dogs) 
ROlHl-2173501 Electrophysiology alter healed myocardial 

inlarction (cats) 
R01HL-21742-01 Frequency dependent drug actions in 

cardiac muscle (rabbits) 
** R23HL-2178301 Ionic control ol contractility in anoxic 

myocardium (rabbits, rats) 
ROlHl-2184501 Human red cell membrane- Structure and 

function 
ROlHL-2186018 Factors influencing responses to 

adrenergic drugs (guinea pigs, rats, cats) 
ROIHL-21995-01 Protein phosphorylation and adrenergic 

eWects 
♦* R01HL-22008-01 Lett ventrivular calcium content and 

contractility (rats) 
♦♦ ROlHL-22039-02 Ion transport in cardiac muscle (dogs, 

rodents, cattle) 
ROlHL-2208802 Metabolic basis for diabetic 

microangiopathy (cattle) 
** ROlHL-2213501 Control ol calcium lluxes across cardiac 

membranes (dogs, rabbits, guinea pigs) 
ROlHL-2213702 Structure-lunction pathology ol isolated 

heart cells (mice, rats) 
ROlHL-2223102 Modulation ol calcium control ol cardiac 

myolibriis (rats) 
ROlHL-22264-01 Regulation ol contraction in vascular 

smooth muscle (dogs) 
ROlHL-2255202 Abnormal alveolar permeability and lung 

disease (sheep) 
ROlHL-22562-02 Mechanism ol cardiac action potential 

propagation (tunicates) 
** ROlHL-22568-01 pH effect in heart cells-lnlluence ol 

cardiac drugs (tissue culture, rats) 
R23HL-22575-01 Factors modilying cardiac digoxin eflects 

and content (dogs, cats) 
ROlHL-22836-01 The spontaneously hypertensive kidney 

(rats) 
ROlHL-2312801 Cardiac contractility -Ischemia and 

hypoxia (rabbits, rats) 
ROlHL-23138-01 Myocardial ischemia (dogs. rats, chick 

embryo) 
** ROlHL-23153-01 Mechanisms of altered CA20 transport in 

ischemic heart (dog. rabbit) 
ROlHL-23602-01 Physiology of renin, aldosterone and 

prostaglandin (human, rats, dogs) 

BIOLOGICAL TRANSPORT, ION EXCHANGE AND 
TRANSPORT, ION CARRIERS (lONOPHORES) 

SEE ALSO ANTIBIOTICS, GRAMICIDIN (UNSPECIFIED) 
SEE ALSO ANTIBIOTICS, VALINOMYCIN 
POlHL-06308-18 0025 Mechanisms and therapy of 

circulatory disease - Subcellular calcium pools in the 

genesis of arrhythmias (dogs) 
POlHL-06308-18 0039 Mechanisms and therapy of 

circulatory disease ■ ANS in regulation of electrophysiology - 

Role of Cyclic nulceotides (animals) 
ROlHL-10503-13 Cardiac ion transport and ultra structure 

(rats, guinea pigs, rabbits) 
POIHL-11351-12 0001 Cellular and molecular 

mechanisms of myocardial function - Ionic control of 

myocardial contractility (animals) 
" P01HL-12738-10 0109 Physiologic pharmacology and its 

clinical applications ■ Effects of calcium blockers on 

skeletal and cardiac muscle (cats) 
" P01HL-I2738-10 0110 Physiologic pharmacology and its 

clinical applications - Physiology and pharmacology of 

arrhythmias (dogs) 
POlHL-13262-07 0022 Arterial wall in atherosclerosis - 

Mechanisms of platelet prostaglanoin formation 
P50HL14153-07 0014 Johns Hopkins Lung Center- 
Chronic diseases of airways - Mediator release in asthma 

(human) 



29 

PliOHl 1421/08 0059 Specialized center ol ii<\riir(h in 

Ihiombosis Energy metabolism and platelet lunclion 

(human) 
POIHM49H5 07 001? Adaptation to hypoxia Direct 

ellect ol hypoxia un pulmonary vascular smooth muscif 

(rats, dogs) 
P60HL 15169 05 0018 Support lor center lor sickle cell 

disease Studies on sickle cell disease (human, rats, 

dogs) 
ROIHl 15580 06 Humoral control ol pulmonary and 

systemic circulation (animals) 
POIHI 15832 06 0012 Chemical structural predispositions 

lo lung iniury Contractile structures and conlractilily in 

cells ol lung respiratory tract 
POIHI 1583506 0021 Study ol muscles related to heart 

disease Fast kinetic studies in muscle subcellular 

organelles (animals) 
POIHI 16117 05 Ion movements and membranes in 

cardiovasculai contiol 
POIHI 161 1 7 05 0001 Ion movements and membranes in 

cardiovascular control Developmental studies of 

contractile cell lunctions (rats, rabbits, elasmobranch) 
' POIHL 16117 05 0003 Ion movements and membranes in 

cardiovascular control Fast kinetic study of calcium 

membrane interactions 
* POIHL 16117 05 0005 Ion movements and membranes in 

cardiovascular control Properties of isolated cell 

membranes (rabbits, cats) 
' POIHL 16117 05 0007 Ion movements and membranes in 

cardiovascular control Physiological and molecular 

properties of lonophores (dogs, rabbits) 
R01HL-163I8-21 Biochemistry and pharmacology of Na-K 

transport 
' ROlHL-1647405 Antibiotic-ion interactions (model 

membranes) 
POIHL 16607 05 0006 Calcium ion and control of 

cardiovascular function - Sarcomere and contractile 

dynamics of striated muscle cells (animals) 
P01H116833 04 0011 Hemoglobin and red cell system in 

hemoglobinopathies - Relationship between hemoglobin and 

RBC membrane in sickling cells (human, rats) 

■ POlHL-16833-04 0016 Hemoglobin and red cell system in 

hemoglobinopathies - Calcium-indiced membrane damage 

in Hb SS disease (human, animals) 
P60HL- 17269-04 0023 National heart and blood vessel 

research and demonstration center - Cardiovascular 

pharmacology -Ischemia, shock and heart failure (dog cat 

rat) 
R01HL17516-04 Role of androgen as a risk factor in 

atherogenesis (human, animals) 
R01HL17853-03 Peripheral circulation in heart failure 

(animals) 

■ ROlHL-18599-02 Cardiovascular pharmacology of 

ionophores (dogs) 
' POlHL-18708-03 0005 Oxygen, energy and contractility in 

cardiac tissue - Cytosolic calcium homeostasis and 

bioenergetics of cardiac tissue (animals) 
ROIHL 19044-03 Effect of drugs on development of 

cardiac failure (cats) 
ROlHL-1922603 Vascular smooth muscle in hypertension 

(rats) 
' ROIHL-19639-02 Permeability transients of carriers. 

channels and heart 
ROlHL-20708-02 Voltage clamp of embryonic heart cell 

aggregates (rat and chick embryos) 
POlHL-20984-02 0001 Cellular mechanisms in cardiac 

hypertrophy - Contractile proteins in cardiac hypertrophy 

(rabbits, calves) 
ROlHL-21 195-02 Innervation of the heart -Acetylcholine 

receptors (frogs) 
R01HL-2I217-01 

platelets 
R23HL-2126202 Sodium-calcium interactions in 

mammalian myocardium (rabbits, cats) 
ROlHL-21367-02 Polyether ionophores -Synthesis of X537A 

and analogs 
R01HL-218I2 02 Actions of drugs and ions on cardiac 

membranes (rabbits, guinea pigs) 
ROlHL-21993-01 Hypertensive hypertrophy-Effects of 

cardiac mechanics (rats) 
ROlHL-22039-02 Ion transport in cardiac muscle (dogs. 

rodents, cattle) 
ROlHL-22239-01 The molecular basis of electrical 

excitability (chick embryos, rats) 
R01HL-22354-0I Alpha-adrenergic effects on heart 

metabolism (rats) 
POlHL-22619-01 0008 Cellular mechanisms of heart 

failure - Molecular mechanisms and diflerential contractile 

responsiveness in VSM (dogs) 
POlHL-2261901 0009 Cellular mechanisms ol heart 

lallure - Sarcoplasmic reticulum in cardiac, skeletal and 

smooth muscle (rabbits, dogs) 
POlHL-22619-01 0010 Cellular mechanisms ol heart 

failure - Mitochondria in heart and smooth muscle (rabbits. 

rats, dogs) 
ROlHL-2277801 Total synthesis of natural cardiotonic 

ionophores 
ROlHL-22836-01 

(rats) 
ROlHL-2339201 



BIO 



ROIHl ?15'r)0l 

\fl IptlOII iMl',) 



M,i'.l 'rll (iMiiuli-. Miiiiliiii- vir»l 



Ion and Shydroxytryptamine transport by 



The spontaneously hypertensive kidney 
Membrane binding and transport of 



BIOLOGICAL TRANSPORT, MEMBRANE MODELS 

SEE AISOMIMHKANI, (RriHROCrK GHOS! AND 
Ml MKRANE 
POIHI 08214 15 U025 Chemii.al and biological piopertiet 
of lipids RiosynlhcM', and biological tunctiont ol 
plasmalogen (cattle) 
PfllHI 08214 15 0040 Chemical and biological properties 
111 lipids Nuclear magnetic resonance sludie-, ol lipid'. 
*• POIHI 12157 II 0038 functions and mechani'.m-, ol cell 
membrane ion tiansport Mc'.hani'.ms and interactions ol 
gases and ions with bilayer membranes (human) 
" ROIHl 12528 10 NMR relaxation of liquid crystal systems 
ROIHl 12760 09 Surtacc studies ol membrane lipids and 
proteins 
•• P50HI 14147 08 0003 Specialized center of research in 
thrombosis Surtace thrombogenicity and phospholipid 
vesicle physical properties 
P50HI 1414/ 08 0014 Specialized center of research in 
thrombosis Theoretical models for electrostatic effects in 
blood clot formation 
** P50HI 1414/ 08 0015 Specialised center of research In 
thrombosis Charge related properties of phospholipid 
surfaces in monolayers and vesicles 
ROIHL 15648 06 Lipid metabolism Transport by lateral 

diffusion (human, rabbit, cattle) 
P60HL 16008 06 0018 Wayne State University 
comprehensive sickle cell center Hemoglobin S and RBC 
membranes Pathogenesis of irreversibly sickled cells 
ROIHL 164/4 05 Antibiotic ion interactions (model 
membranes) 

Human red cell membrane in 
Rheology of erythrocyte membrane 



Human red cell membrane in 
Modehng membrane mechanics and 



POIHL 16851 04 0001 

health and disease 

(human, amphiuma 
POIHL- 16851 04 0003 

health and disease 

blood rheology 
ROIHL 1757604 Role of sphingomyelin in biomembranes 

and bilaycrs (rats, other mammals) 
R01HL-18048-04 Dynamics of artificial and biological 

membranes (human) 
ROlHL-18255-04 Lipid-protein interactions and calcium 

transport (models) 
POlHL-18577-03 0003 Lipoproteins -Cell surtacc 

interactions Mechanism of lipid exchange in lipoproteins 

and cell membranes 
ROlHL-19065-02 Molecular oxygen in biological fluids 
ROIHL I9I4803 Myocardial organelle lipid structure and 

function (dog. rat) 
ROlHL-19392-03 Spectroscopic studies of respiratory 

metalloproteins 
ROlHL-19459-03 Dynamics of atherogenesis and 

lipoprotein formation (human, rabbit) 
ROlHL-20073-02 Blood compatible materials by fluid 

perfusion (human, dogs) 



Probes of heart and nerve membranes- 



Mechanisms and cellular functions of ion 



ROlHL-20254-02 

Fluorescent dyes 
ROIHL-2072502 

transport 
** ROlHL-21404-01 Raman spectroscopy of erythrocyte and 

model membranes (human) 
ROlHL-223 15-01 Intraoperative cardiac oxygen supply 

demand (dogs, rabbits, rats) 
ROlHL-22562-02 Mechanism of cardiac action potential 

propagation (tunicates) 
ROlHL-22771-01 Thrombogenic phospholipid surfaces 

(cattle) 
** ROIHL-23183-01 Voltage dependent conductance in 

membranes 

BIOLOGICAL TRANSPORT, MEMBRANE 
PERMEABILITY AND TRANSPORT 

SEE ALSO CARDIOVASCULAR SYSTEM, ENDOTHELIUM 

PERMEABILITY 
SEE ALSO CEREBROVASCULAR SYSTEM. BLOOD-BRAIN 

BARRIER 
SEE ALSO CEREBROVASCULAR SYSTEM. BLOOD- 

CEREBROSPINAL FLUID BARRIER 
SEE ALSO GASTROINTESTINAL FUNCTION ABSORPTION- 
TRANSPORT (GENERAL) 
SEE ALSO KIDNEY FUNCTION, GLOMERUUR FILTRATION 
SEE ALSO KIDNEY FUNCTION, RENAL TUBULAR TRANSPORT 
SEE ALSO MEMBRANE. MEMBRANE (BIOLOGICAL) STRUCTURE 
SEE ALSO METABOLIC DISORDERS INBORN TRANSPORT 

DISORDERS 
SEE ALSO PREGNANCY CIRCULATION, PUCENTAL TRANSFER 
SEE ALSO RESPIRATORY FUNCTION PULMONARY DIFFUSION 
SEE ALSO SKIN ABSORPTION 
" ROlHL-00082-30 
frogs, rats) 
ROlHL-02334-23 



Transmembrane movements (barnacles, 
Micropuncture study of kidney function 



calcium and potassium ionophores 



•Excludes routine methodology OR covers only general projects which preclude indexing at the specific level 
Oriented significantly to above subject. 



(rats, animals) 
R01HL04457-20 Cellular aspects of active transport (fish, 

rabbits, anurans. turtles) 
POlHL-06285-18 0195 Cardiovascular-respiratory 

physiology and biochemistry - Thyroid thermo genesis and 

sodium transport (rats) 
POlHL-06285-18 0196 Cardiovascular-respiratory 

physiology and biochemistry • Hormonal regulation of 

sodium transport -Epithelial cell membranes (toads) 

Icontd) 



M Grant has subproiects describing specific research aspects 
See Appendix for investigator's name and grant number 



BIO 

POlHL-06285-18 0197 Cardiovascularrespiratoty 

physiology and biochemistry - Microperfusion and 

micropuncture of renal tubules (hamsters, desert rats) 
*• P01HL06285-18 0198 Cardiovascular-respiratory 

physiology and biochemistry - Renal tubular secretion of 

hydrogen ion (animals) 
POlHL-06285-18 0200 Cardiovascular-respiratory 

physiology and biochemistry - Medullary counter-current 

system (animals) 
** POlHL-06285-18 0203 Cardiovascular-respiratory 

physiology and biochemistry - Pathways of lipid transport 

in the blood (animals) 
** POlHL-06285-18 0204 Cardiovascular-respiratory 

physiology and biochemistry - Lipoprotein lipase and 

triglyceride transport in chylomicrons (guinea pig, rat) 
POlHL-06285-18 0211 Cardiovascular-respirator> 

physiology and biochemistry • Purple membrane of 

Halobacteria 
POlHL-06285-18 0212 Cardiovascular-respiratory 

physiology and biochemistry - Membrane structure and 

function-Gap junction (bovine) 
POlHL-0631417 0054 Immunologic mechanisms in 

cardiovascular disease ■ Physiology of cell communications 

(mice, frogs, guinea pigs) 
POlHL-06664-17 Cardiopulmonary function in remediable 

vascular disease 
POlHL-0666417 0036 Cardiopulmonary function in 

remediable vascular disease - In vitro studies on the 

mechanism of ischemic damage to cells (rabbits) 
** P01HL06664-17 0038 Cardiopulmonary function in 

remediable vascular disease - The dynamics of ADH- 

stimulated osmotic water flow 
** POlHL-06664-17 0040 Cardiopulmonary function in 

remediable vascular disease - The coupling of ion transport 

to metabolism (toads) 

Regulation of ventilation and 
Electron microscope core research 



M 



POlHL-08805-15 0042 
pulmonary circulation 
laboratory 

POlHL-08805-15 0048 
pulmonary circulation 



Regulation of ventilation and 
Permeability of alveolo -Capillary 

membrane in normal pulmonary hypertensive lung 
R01HL0889314 Structure and function of membrane 

proteins (human) 
POlHL-0889914 0073 Tolerance to respiratory gases in 

health and disease - Biophysical mechanisms Involved in 

isobaric gas counterdiffusion syndrome 
ROlHL-08977-14 Quantitation of flow and solute flux in 

microvessels (cats, rats) 
R01HL0912514 Ultrastructural cytochemistry (human, 

chick) 
ROlHL'09364-14 Ion transport by heart mitochondria 

(cattle, rat, rabbit) 
ROlHL-09610-14 Control of cholesterol metabolism-Bile 

acid transport 
ROlHL-09906-13 Membrane transport processes in red 

blood cells 
ROlHL-09906-13 0021 Membrane transport processes In 

red blood cells - Membrane potentials in human red blood 

cells due to proton gradients 
ROlHL-09906-13 0022 Membrane transport processes in 

red blood cells - Anion transport in dog and cat red cells 
ROlHL-0990613 0024 Membrane transport processes in 

red blood cells - Inhibition of sulfate transport in human 

RBCs by isothiocyanic acid esters 
ROlHL-10503-13 Cardiac ion transport and ultrastructure 

(rats, guinea pigs, rabbits) 
ROIHL-10940-13 Lipid transport (rabbits, cattle, chickens) 
ROlHL-1 II 53-12 Quantitation of flow and solute flux in 

microvessels (cats, rats) 
P01HL-11310-12 0102 Mechanisms of cardiovascular 

disease - Cardiac membrane and ion mobility (dogs) 
ROlHL-1 1901-12 0017 Effects of metabolic surgery on 

the hyperlipidemias - Membrane permeability, blood 

viscosity, oxygen uptake-Rheology studies (rabbits) 
POlHL-12157-11 0033 Functions and mechanisms of cell 

membrane ion transport - Immunology aspects of active 

Na-K transport in sheep red cell (also human, mice) 
P01HL12157-11 0056 Functions and mechanisms of cell 

membrane ion transport - Isotopic fluxes in synthetic 

strands of heart cells (chick embryo) 
POlHL-12157-11 0057 Functions and mechanisms of cell 

membrane ion transport - Electrophysiological 

investigations of synthetic strands of heart muscles (rats) 
POlHL-12157-11 0058 Functions and mechanisms of cell 

membrane ion transport - Ionic and osmotic regulation in 

toadfish-A euryhaline aglomerular teleost 
ROlHL-12528-10 NMR relaxation of liquid crystal systems 
POlHL-12738-10 0044 Physiologic pharmacology and its 

clinical applications - Cardioactive drugs and 

electrophysiological properties of cardiac cells (sheep) 
POlHL-1273810 0110 Physiologic pharmacology and its 

clinical applications - Physiology and pharmacology of 

arrhythmias (dogs) 
ROlHL-12839-09 Flow, transport and membrane 

phenomena in blood (human) 
ROlHL-12879-09 0002 Pulmonary transport and 

metabolism in vivo - Osmotic compartmental model of 

barrier exchange 
ROlHL-12879-09 0011 

metabolism in vivo - 



cells (human, animals) 



Pulmonary transport and 
Membrane characteristics of lung 



30 

ROlHL-12974-10 Tracer kinetics, flows and masses in 

body organs (human, dogs) 
ROlHL-13028-09 Regulation of myocardial fatty acid 

metabolism (rats) 
ROlHL-13029-09 Metabolic regulation of sugar transport 

(pigeons, rats) 
ROlHL-13172-10 Post-trauma lung mechanics and fluid 

exchange (human, dogs, monkeys) 
ROlHL-1323709 Erythrocytes during early development 

(human, animals) 
ROlHL-13256-08 Amino acid transport by red cell 

membranes (pigeons) 
ROlHL-13306-08 Pharmacological control of cardiac 

membrane currents (cattle, rabbits) 
ROlHL-13339-08 Pharmacology of developing cardiac 

tissues (chick embryo) 
R01HL13596-07 Clearance of plasma proteins from 

alveoli 
ROlHL-13645-11 Tryptophan-induced pulmonary 

emphysema (cattle, goats, rabbits) 
R01HL-14092-07 Homeostatic regulation of plasma choline 

(rats, dogs, chickens) 
P50HL-14230-07 0092 A/S SCOR-Lipids. atherosclerosis 

and thrombosis - Tissue lipids -Cell culture studies 

(human) 
POlHL-1438807 0191 Regulation of the circulation in 

pathological states - Regulation of chloride transport in 

epithelial membranes (turtles) 
POlHL-14388-07 0192 Regulation of the circulation in 

pathological states - Renal tubular secretion of magnesium 

(rats) 
POlHL-144 14-07 0014 Environmental influences on 

cardiorespiratory and cellular functions - Temperature and 

acid-base status in tissues, cells, and subcellular system 
POlHL-144 14-07 0016 Environmental influences on 

cardiorespiratory and cellular functions - Effects of 

pressure on membrane and cellular function (human. 

rabbits) 
ROlHL-14483-08 Energy conservation in heart 

mitochondria (cattle, E coli, human) 
ROlHL-14781-08 Lipid deposition in mammalian cells 

(mice) 
ROlHL-14820'07 Factors affecting physiology of biological 

membranes (human) 
ROlHL-14854-07 Lung and tissue mechanics (monkeys, 

dogs) 
P60HL-1515707 0011 Comprehensive center for sickle 

cell disease - Development of specific anti-sickling 

compound (human) 
P60HL-151 57-07 0018 Comprehensive center for sickle 

cell disease - Red blood cell membrane physiology in sickle 

cell anemia (human) 
P60HL-15162-07 0017 Comprehensive sickle cell center - 

Hemoglobin, erythrocytes and sickle cell anemia (human, 

rabbit) 
P60HL-1516207 0020 Comprehensive sickle cell center - 

Biophysical studies of normal and sickle red cells (human) 
ROlHL-15504'05 Animal model for studies on averting 

atherosclerosis (swine) 
ROlHL-15622-05 Computer simulation in cardiology (rats, 

dogs) 
ROlHL-15793-06 Molecular aspects of erythrocyte 

membrane resealing (human) 
POlHL-15835-06 0021 Study of muscles related to heart 

disease - Fast kinetic studies in muscle subcellular 

organelles (animals) 
P60HL- 15999-05 0014 Miami comprehensive sickle cell 

center - Biochemical and morphological parameters of 

sickle cells (human) 
P60HL-16008-06 0018 Wayne State University 

comprehensive sickle cell center - Hemoglobin S and RBC 

membranes -Pathogenesis of irreversibly sickled cells 
R01HL16093-05 Functional properties of hemoglobin and 

erythrocytes 
POlHL-161 17-05 0007 Ion movements and membranes in 

cardiovascular control - Physiological and molecular 

properties of ionophores (dogs, rabbits) 
ROlHL-16328-06 Membrane electrical properties of 

vascular muscle (human, animals) 
ROlHL-1647405 Antibiotic-ion interactions (model 

membranes) 
ROIHL-165 12-04 Lipoprotein metabolism and hormonal 

regulation (chickens) 
ROlHL-16582-05 Artificial lungs (dogs) 
POlHL-16607-05 0001 Calcium ion and control of 

cardiovascular function - Bilayer lipid membranes, 

antibiotic probes, and SR function 
P01HL16607-05 0005 Calcium ion and control of 

cardiovascular function - Chemical modifications of the 

sarcoplasmic reticulum membranes (rabbits) 
ROlHL-16660-06 Phospholipid-cholesterol and 

phospholipid-protein interactions 
ROlHL-16674-05 Airborne metals and lung permeability 

(bullfrogs, rats) 
ROlHL-167 11-05 RBC and endothelial membrane material 

characteristics (human) 
ROlHL-16746-04 Design of ion-selective molecules 
POlHL-16833-04 0008 Hemoglobin and red cell system in 

hemoglobinopathies - Membrane associated phenomena in 

SS disease 



BIO 

POlHL-16833-04 0016 Hemoglobin and red cell system in 
hemoglobinopathies Calcium-indiced membrane damage 
in Hb SS disease (human, animals) 



POIHL- 16833-04 0017 
hemoglobinopathies 
effect (human) 

POlHL-1685104 0006 
health and disease 



Hemoglobin and red cell system in 
Sulfhydryl group blockade antisickling 



Human red cell membrane in 
Hexose transport and erythrocyte 

membrane proteins (human) 
P60HL- 17269-04 0022 National heart and blood vessel 

research and demonstration center - Medicinal chemistry 

(rabbit, dog, guinea pig) 
P60HL- 17269-04 0045 National heart and blood vessel 

research and demonstration center - Regulation of 

lipogenesis in hyperlipoproteinemia (human, tissue culture) 
ROlHL-17411-04 Molecular studies of red blood cell 

spectrin (human) 
ROlHL-1745204 Depolarization induced cardiac 

automaticity (human, animals) 
ROlHL-17571 03 Study of membrane permeability by NMR 

relaxation (human) 
ROIHL 17576-04 Role of sphingomyelin in biomembranes 

and bilayers (rats, other mammals) 
ROlHL-17596-03 Leukocyteendothelial interactions (rats) 
P50HL- 17648-04 0014 Study of ischemic heart disease - 

Antidysrhythmic drugs and mammalian cardiac Purkinje 

fibers (sheep, dog) 
P50HL 17669-04 0022 Ischemic heart disease center 

(SCOR) Pathological studies of human and experimental 

ischemic heart disease 
ROlHL-1 7882-04 Regulation of HMG-COA reductase and 

sterol synthesis (human, mammals) 



Mammalian renal microcirculation 
Limiting factors in oxygen uptake in the 
Regulatory mechanisms in blood 



'Excludes routine nethodology OR covers only general projects which preclude indexing at the specific level. 
"Oriented significantly to above subject. 



R01HL17902-04 

(hamsters) 
R01HL17967-04 

lung 
ROlHL-17998-04 

circulation (dogs) 
ROlHL-18022'03 Role of multicomponent diffusion in gas 

exchange (avian eggs) 
ROlHL-18028'03 Absorption of nonvolatile compounds 

from the lung 
R01HL18038-03 Structure and function of heart 

mitochondria (cattle) 
ROlHL-18048-04 Dynamics of artificial and biological 

membranes (human) 
ROlHL-18053-03 Intracellular Ionic activities in heart 

muscle (frogs) 
ROlHL-1806802 Chemistry and activity of homologous 

heparin fractions (rodents) 
ROlHL-18148-04 Adrenal catecholamine secretion 
ROIHL- 18206-04 Regulation of metabolism in oxygen 

deficient hearts (rats) 
ROlHL-18226-04 Mechanism of oxygen supply to tissue 

(human, animals) 
ROlHL-18255-04 Lipidprotein Interactions and calcium 

transport (models) 
ROlHL-18292-04 Vasodilation and microvascular oxygen 

delivery (dog. hamster) 
ROlHL-18599-02 Cardiovascular pharmacology of 

ionophores (dogs) 
ROlHL-18647-03 Ischemic myocardial injury in cultured 

heart cells (rats) 
ROlHL-18660-03 Neurotransmitter receptors in human 

erythrocytes 
R01HL18798-04 0001 Nervous and ionic factors in 

sudden cardiac death - Potassium loss during myocardial 

ischemia (rabbits) 
ROlHL-18818-04 Stereochemical mechanism of sickling of 

hemoglobin S (human) 
P01HL18827-02 0001 Platelet vessel wall interactions in 

thrombogenesis - Role of endothelial cells in the production 

of thrombi (human, cattle) 
ROlHL-19000-03 Irreversible myocardial injury (rats) 
ROlHL-19068-03 Changes in membrane properties during 

erythropoiesis (chick embryo) 
ROlHL-19082-01 Hypoxia-induced relaxation of vascular 

smooth muscle 
ROlHL-19148-03 Myocardial organelle lipid structure and 

function (dog, rat) 
P50HL19 153-02 0004 SCOR -Pulmonary edemas-Eitology, 

pathogenesis - Physical mechanisms in lung transvascular 

transport-Math models (sheep) 
P50HL-19153-02 0005 SCOR -Pulmonary edemas-Eitology. 

pathogenesis - Lung vascular permeability measured by 

indicator dilution methods (sheep) 
POlHL-19242-02 0002 Study of vascular smooth muscle ■ 

Vascular smooth muscle response to serum lipoproteins 

(rats) 
ROlHL-19315-03 Study of glomerular permeability (fish, 

turtle, frog, chordates, Crustacea) 
R01HL1939902 Atherosclerosis-Early events and 

regression factors (rats) 
ROlHL-19463-02 Pathophysiology of acute renal failure 

(rats) 
ROlHL-19639-02 Permeability transients of carriers. 

channels and heart 
ROlHL-1967303 Surgical aspects of shock and hypoxia 

(dogs, monkeys, rats) 
ROlHL-19733'03 Absorption of antigen through inflamed 

lungs (rabbits) 

(contd) 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



BIO 



POIHI 1973/0? 0004 Cdlulti ind molrculac aspocU ol 

ttspiiitory phyiiok)|y Rapid taaclions and eiYlhtocyta 

•>chan|ts ol blood duiini taspiialory tianspoil 
POIHI 19737 0? 0008 Cellular and moleculai asptcts ol 

r«spi[ato(> physiology Kinatics ol movamant ol acid 

matabolitas Icom call to capillani blood (do|s) 
ROIHI 20061 02 Saium lipoproteins and cell cholesterol 

metabolism (rats, human) 
ROIHI 20070 02 Alpha 1 anlitrypsm deliciency (human 

hamsters) 
ROIHI 20073 02 Blood compatible materials by fluid 

perlusion (human, dogs) 
R01H12015302 Intracellular pH and myocardial 

electropharmacology (dogs, guinea pigs) 
' ROIHI 20177 02 Etiects ol erythrocyte detormability on 

tissue perlusion (rats) 
ROIHL 2023002 Analysis ol the action potential ol 

cardiac muscle (sheep) 
ROIHL 20254 02 Probes ol heart and nerve membranes 

Fluorescent dyes 
ROIHI 20283 02 Maintenance ol cellular integrity in 

ischemic hearts (cats) 

* ROIHL 20303 03 Cholesterol distribution in erythrocyte 

membrane (human, animals) 

* ROIHL 20308 02 Regulation ol myocardial acylcarniline 

transport (rats) 
ROIHL 20366 03 Protein turnover and ammo acid 

transport by lung (rats) 
ROlHL-20544 02 Integrated regulation o( myocardial 

energy metabolism (rats, guinea pigs) 

* POIHL 20592 02 0013 Cell biology ol cardiac and 

skeletal muscle Sarcoplasmic reticulum in skinned 
muscle cells (Irogs) 

* ROIHL 20708-02 Voltage clamp ol embryonic heart cell 

aggregates (rat and chick embryos) 
R01HL20711 01 Structure-function relationships in red 

cell NA-K pumps (goats) 
ROlHL-20720-02 Myocardial protection during 

cardiopulmonary bypass (dogs) 
ROIHL 2072502 Mechanisms and cellular functions of ion 

transport 
ROIHL 20859-02 Beta adrenergic catecholamine receptor 
ROlHL-2088202 Interactions of plasma lipoproteins with 
erythrocytes (Rhesus, human) 
'* P60HL-20985-01 0004 Northern California sickle cell 

center ■ Characterization of irreversibly sickled cells 
(human) 
P60HL-2098501 0006 Northern California sickle cell 

center - Antisickling properties ol imidoesters (human, rats) 
POlHL-2099402 0007 Dynamics of neutrophil elastase in 

the lung ■ The etiology of experimental emphysema (dogs) 
ROlHL-21009-02 Effects of air pollutants on lung cells in 

culture (rats) 
ROlHL-21014-01 Mechanism of the inotropic action of 

cardiac glycosides 
POlHL-2 1016-02 0008 Sickle cell anemia and other 
hemoglobinopathies ■ The clinical variations of sickle cell 
anemia 
ROlHL-2 103801 Electrically induced cardiac EM- 

histochemical changes (animals) 
R23HL-2 105002 Mechanisms of re-expansion pulmonary 

edema (rabbits) 
ROlHL-21076-02 Lung fluid, protein exchange after 

hemorrhagic shock (sheep) 
ROlHL-2 1099-02 Subcellular changes of blood vessels in 

hypertension (rats) 
ROlHL-2 113602 Ion activities and transport in cardiac 

muscle cells (sheep) 
R23HL-2 11 50-02 Regulation of airway mucous glands and 

ion transport (dogs, ascaris) 
ROlHL-21179-01 Volume regulation-Role of the membrane 

potential (amphiuma) 
ROlHL-21195-02 Innervation of the heart-Acetylcholine 

receptors (frogs) 
R23HL-2121301 A model for calcium homeostasis in 
excitable tissue (marine worms) 
** ROlHL-21217-01 Ion and 5-hydroxytryptamine transport &/ 
platelets 
ROlHL-2129402 Voltage clamp of isolated cardiac 
Purkinje cells (dogs) 
** ROlHL-2 1376-02 Blood-gas barrier solute and water 

transport (rabbits) 
** ROlHL-2146901 Active transport and effect of CAOO in 
sickle cell (human) 
ROlHL-21525-02 Effect of cations, anions and water upon 

blood vessels (dogs, rats) 
ROlHL-2157001 Antiarrhythmic studies on 2-substituted 

aminoindenes (dogs) 
ROlHL-21812-02 Actions of drugs and ions on cardiac 
membranes (rabbits, guinea pigs) 
** ROlHL-2184501 Human red cell membrane -Structure and 

function 
•* ROlHL-21849-02 Control of sodium transport and cellular 
respiration (toad bladder) 
R01HL-22039-02 Ion transport in cardiac muscle (dogs. 

rodents, cattle) 
ROlHL-22101-02 Hormone-substrate interaction in diabetic 
myocyte (dogs, rats) 
** ROlHL-22135-01 Control of calcium fluxes across cardiac 
membranes (dogs, rabbits, guinea pigs) 
ROlHL-22177-02 Mechanisms of control of pulmonary 
smooth muscle (dogs) 



ai 

ROlHt 22231 02 Modulillon ol calcium control ol cirdlic 

myolibrili (rats) 
ROIHL 22264 01 Regulation ol contriclion in vascular 

smooth muscle (dogs) 
ROIHL 22281 01 Microprobe analysis and metabolite 

levels ol ischemic mycardium (dogs) 
ROIHL 22327 01 

skin (swine) 
ROIHI 22502 01 

platelet secretion 
ROIHL 22549 02 

membrane (dogs) 
ROIHL 22552 02 

disease (sheep) 
ROIHL 22562 02 



Transport ol arterial blood giMl through 

Role ol phospholnositides in human 
Transport scioss alveolar capillary 
Abnormal alveolar permeabrlity and lung 



Mechanism of cardiac action potential 
propagation (tunicates) 
ROIHL 22568 01 pH effect in heart cells Influence of 
cardiac drugs (tissue culture, rats) 
*• ROIHL 22569 02 Intestinal secretion -Capillary and tissue 
forces (dogs, cats) 
R23HL 22575 01 Factors modilying cardiac digoxin effects 

and content (dogs, cats) 
ROIHL 2288301 Lung epithelial cell interactions in vitro 
** ROIHL 22924 01 The airway mucosal barrier (guinea pigs) 
** R01HL22981 17 Membrane associated functions in 
microorganisms (bacteria, protozoa) 
ROlHL-23015-01 Mechanisms of hypo^incotic pulmonary 

edema (human, dogs) 
R01HL2313801 Myocardial ischemia (dogs. rats, chick 

embryo) 
ROIHL 23142 01 Mechanisms of membrane injury in 

myocardial ischemia (dog) 
ROIHL 23153-01 Mechanisms of altered CA20 transport in 

ischemic heart (dog. rabbit) 
ROlHL-23166-01 Pathology of mitochondria in ischemic 
myocardium (rats, cattle) 
** ROlHL-23183-01 Voltage dependent conductance in 
membranes 
ROIHL 23210 01 Biology ol normal and hypertrophied 
pulmonary vessels (cat. human) 
** ROlHL-23392-01 Membrane binding and transport of 
calcium and potassium ionophores 

BIOLOGICAL TRANSPORT, PASSIVE TRANSPORT 

POlHL-06285-18 0199 Cardiovascular-respiratory 

physiology and biochemistry - Renal tubular reabsorption of 

sodium chloride (hamsters, rabbits) 
POlHL-06308-18 0035 Mechanisms and therapy of 

circulatory disease ■ Mechanisms for electrophysiological 

changes in myocardial infarction (dogs) 
ROIHL 1283909 Flow, transport and membrane 

phenomena in blood (human) 
ROlHL-13029-09 Metabolic regulation of sugar transport 

(pigeons, rats) 
P01HL1438807 0192 Regulation of the circulation in 

pathological states - Renal tubular secretion of magnesium 

(rats) 
ROlHL-20725-02 Mechanisms and cellular functions of ion 

transport 
P60HL-20985-01 0004 Northern California sickle cell 

center - Characterization of irreversibly sickled cells 

(human) 
R23HL-21213-01 A model tor calcium homeostasis in 

excitable tissue (marine worms) 
ROlHL-22135-01 Control of calcium fluxes across cardiac 

membranes (dogs, rabbits, guinea pigs) 

BIOLOGICAL TRANSPORT, PASSIVE TRANSPORT, 
DIFFUSION 

R01HL08977-14 Quantitation of flow and solute flux in 

microvessels (cats, rats) 
ROlHL-12760-09 Surface studies of membrane lipids and 

proteins 
P01HL14388-07 0191 Regulation of the circulation in 

pathological states Regulation of chloride transport in 

epithelial membranes (turtles) 
** ROlHL-15648-06 Lipid metabolism -Transport by lateral 

diffusion (human, rabbit, cattle) 
** ROlHL-18004-02 Transport through arterial wall- 
Biophysical aspects (rabbits) 
ROlHL-18736-03 Protein transport through arterial tissue 

(rabbits) 
** R01HL19008-02 Carbon dioxide diffusion in lung and 

muscle tissues (dogs) 
ROlHL-19065-02 Molecular oxygen in biological fluids 
ROlHL-1945402 Rheological factors in transport across 

arterial wall (dogs) 
" R01HL1949103 Mechanism of iron storage and 

mobilization by ferritin (horse) 
ROlHL-22235-01 Mechanism of cardiac pacemaking 

(rabbits) 
ROlHL-22843-01 Pulmonary physiology in liquid ventilation 

(lambs) 
BIOLOGICAL TRANSPORT, PASSIVE TRANSPORT, 
OSMOSIS 

SEE ALSO BODY FLUID BALANCE, OSMOTIC PRESSURE 

SEE ALSO CELL FLUIDS. OSMOTIC PRESSURE 
R01HL0990613 0019 Membrane transport processes in 

red blood cells - Hemoglobin change and membrane 

potentials in red blood cells at varying volumes 



BIO 

POIHI 143««0; 0183 Regulalion ol the circulation m 

pgtholugiial ililej Vawprtsun in cardiovascular 
regulalion (dogs, rils) 
ROIHI 19320 03 Angiotensin neurophi(macolO|y 

Relationship to sodium 
ROIHI 211/901 Volume regulation Role ol the membrane 
potential (amphiuma) 
BIOLOGICAL TRANSPORT, SECRETORY 
MECHANISMS 

Structural aspects ol lung turlaclant 



Micropuncluie study of kidney lunction 



ROlHlOl/70 26 
system (rats) 
ROIHL 02334 23 
(rats, animals) 
ROIHL 02/51 21 function and metabolism ol serum 

albumin (mammals, fish, amphibians) 
POIHL 031/4 23 0009 Mechanisms ol acute vascular 

reaction to injury Mast cell Irpid interaction (human, rats) 
ROIHL 03181 21 002/ Hemodynamics as applied lo 

surgical problems Hemodynamic studies ol the Gl tract 
(dogs) 
P01HL06285 18 0189 Cardiovascular respiratory 

physiology and biochemistry Mucociliary clearance (c»t», 
dogs) 
POIHL 06285 18 0198 Cardiovascular respiratory 

physiology and biochemistry Renal tubular secretion ol 
hydrogen ion (animals) 
POIHL 06285 18 0200 Cardiovascular respiratory 

physiology and biochemistry Medullary counter current 
system (animals) 
POIHL 06835 1/ 0038 Cardiovascular disease Effect ol 

chronic administration of angiotensin antagonist (rats) 
P01HL06835 17 0056 Cardiovascular disease 

Angiotensin analogs Sarcosine on arterial pressure, 
aldosterone (dogs) 
POIHL 08682-15 0027 Regulation of the cardiovascular 

system Cardiac mechanoreceptors Reflex regulation ol 
renal function (dogs) 
P01HL09011 15 0015 A research and resource program 
in blood - Regulation of synthesis and transport of diverse 
proteins in liver (rats) 
ROlHL-0992113 Mechanisms related to congestive heart 
failure (dogs, human, rat) 

* ROIHL 1061213 0020 Humoral factors in heart failure 

and hypertension - The control of renin release in the dog 

* ROlHL-10612-13 0021 Humoral factors in heart failure 

and hypertension - The control of aldosterone secretion 

(dogs) 
POlHL-1167811 0046 Cardiovascular dynamics and their 

control - Regulation of aldosterone secretion and related 

factors (dogs) 
POlHL-1167811 0047 Cardiovascular dynamics and their 

control - Unidentified pituitary factor in regulation of 

aldosterone secretion (rats) 

* POlHL-1167811 0066 Cardiovascular dynamics and their 

control - Closed-loop analysis of the aldosterone control 

system (dogs) 
ROIHLI 1901-12 0014 Effects of metabolic surgery on 

the hyperlipidemias - Effect of bypass on gastrin levels 

(dogs, human) 
ROlHL-12650-08 Environmental pathobiology of the lung 

(hamsters, rats) 

* ROlHL-12990-09 Control of antidiuretic hormone secretion 

and metabolism (dogs. rats, rabbits) 
ROlHL-1340509 Regulation of lipid metabolism in the 

lung (rats) 
ROlHL-13885-08 0009 Cystic fibrosis and pulmonary 
disease - Respiratory mucus glycoproteins (human, rabbits) 
■* ROlHL-13917-20 Secretion and effects of adrenal 
hormones (human, rabbits, sheep) 
P50HL1414708 0018 Specialized center of research in 

thrombosis • Biochemical aspects of platelet function in 
thrombosis and cell growth (human) 
P50HL142 14-07 0021 Newborn lung center for hyaline 

membrane disease - Development of surfactant system- 
Surfactant production and release (rat. rabbit) 
P50HL-14214-07 0022 Newborn lung center for hyaline 

membrane disease • Functional integrity of surfactant 
system-Hyaline membrane disease (lamb, rat) 
P50HL-14217-08 0059 Specialized center of research in 

thrombosis • Energy metabolism and platelet function 
(human) 
P50HL-14237-07 0004 Support for arteriosclerosis center 

- Synthesis, secretion of normal, abnormal plasma 
lipoproteins (rodents, monkeys) 
POlHL-14388-07 0179 Regulation of the circulation in 

pathological states - Cultured muscle cells and their cross- 
innervation in vitro (rats, sheep) 
** POlHL-14388-07 0192 Regulation of the circulation in 

pathological states • Renal tubular secretion of magnesium 
(rats) 
ROlHL-15307-06 Central nervous control of renin and 

blood pressure (dogs) 
ROlHL-15427-06 Secretion of plasma lipoproteins (rats) 
P01HL15832-06 9001 Chemical-structural predispositions 

to lung injury • Tissue culture studies of lung cell function- 
Core facility 
POlHL-16137-05 0008 Alveolar biology • Macromolecular 

events in pulmonary cells in toxic environments (animals) 
ROlHL-16714-05 Endothelial cell communication in 
homeostasis (human, mammals) 
** ROlHL-16730-03 Physiology of mucociliary transport (rats, 
frogs, rabbits) 

(contd) 



'Excludes routine methodotogy OR covers only general projects whlcti preclude 
**0riented significantly to above subject. 



indexing at the specific level. 



M Grant has subprojeds descnbing specific research aspects 
See Appendix for investigator's name and grant number. 



The endocrine kidney in hypertension 



Human alphalantitrypsin synthesis in 
Cyclic nucleotides and calcium in 



BIO 

ROIHL-18019-04 
(mice) 
** R01HL18148-04 Adrenal catecholamine secretion 

ROlHL-18181-04 Surfactant metabolism-Alveolar cells and 

lung disease (mice, rabbits) 
R01HL18340-04 Electron microscopy of the 

juxtaglomerular apparatus (rats) 
POlHL-18575-03 0005 Mechanisms of vascular changes 

m hypertension - Renin synthesis in normotensive and 
hypertensive pigs (also rats, dogs) 
ROlHL-18601-01 Regulation of neurotransmitter release by 

adenosine (tats) 
ROlHL-18876-03 
vitro 
** R01HL18937-03 
platelets (human) 
ROIHL 1899504 Cardiovascular determinants of 

catecholamine release (dogs) 
P50HL-19157-02 0003 Studies in cystic fibrosis and 

bronchiolitis - Nasal mucosal function in patients with 
cystic fibrosis 
** P50HL-19I57-02 0004 Studies in cystic fibrosis and 

bronchiolitis - Macromolecular regulators of mucus 
secretion-Invertebrate model 
P50HL-19157-02 0007 Studies in cystic fibrosis and 

bronchiolitis - Analysis of cystic fibrosis factors (human) 
M P50HL-19160-02 Mucus abnormality in cystic fibrosis 
** P50HL-19160-02 0001 Mucus abnormality in cystic 

fibrosis • Regulation of respiratory secretions (rat. human) 
** P50HL-19160-02 0002 Mucus abnormality in cystic 

fibrosis • Ultrastructure. cytochemistry of pulmonary 
secretion (human, rat) 
R01HL1916803 Biosynthesis of plasma lipoprotein (rats, 
rabbits) 
** P50HL-19185-02 0001 Pulmonary SCOR-Neonatal 

respiratory distress syndromes - Sites of synthesis, 
secretion and structure of surface active material (rat) 
** P50HL-19185-02 0003 Pulmonary SCOR-Neonatal 

respiratory distress syndromes - Factors affecting formation 
and release of pulmonary surfactant in fetal lambs 
P50HL-19187-02 0004 Pediatric pulmonary SCOR-Hyaline 

membrane disease • Hyaline membrane disease -Surface 
active material, lamellar bodies (mice, rats) 
ROlHL-1972103 Lung inflammation-Lysosomal proteases 
and liposomes (human, rabbits) 
** ROlHL-20278-02 Cellular mechanisms of renin secretion 

(rats) 
** ROlHL-20366-03 Protein turnover and amino acid 
transport by lung (rats) 
ROlHL-2086802 Regulation of glycoprotein biosynthesis in 

lung (swine) 
P50HL-21006-02 0003 Specialized center of research in 
arteriosclerosis ■ Transport of vitamin A in plasma (human, 
rat) 
R23HL-2115002 Regulation of airway mucous glands and 

ion transport (dogs, ascaris) 
R23HL-21369-02 Tracheal mucin synthesis in experimental 

bronchitis (rats) 
R23HL-21413-02 Structure and function of platelet 

calcium-binding protein (human) 
ROlHL-2175611 Vascular disease-Cytochemistry and 

ultrastructure (human, rats. mice, hamsters) 
ROlHL-21996-01 Alteration of digitalis and aldosterone 

disposition (rats, rabbits, mice, dogs) 
ROlHL-22051-01 Role of angiotensin II in vasopressin 
release (human) 
** ROlHL-22333-01 

(rats) 
** ROlHL-2244401 

culture (human) 
" ROlHL-22502-01 
platelet secretion 
ROlHL-22561-01 

circulation (cats) 
ROlHL-22569-02 
forces (dogs, cats) 
** POlHL-22633-01 0001 Cellular and molecular biology of 

lipoprotein metabolism - Secretion of lipoproteins by the 
perfused liver (rats, rabbits) 
'* R23HL-22728-01 Neural control of renin secretion (dogs) 
Regulation of hepatic production of HOL 



Role of angiotensin 
Cellular basis of small airways function 
Bronchial mucus production in organ 
Role of phosphoinositides in human 
Hormonal control of mesenteric 
Intestinal secretion -Capillary and tissue 



ROIHL-22812-01 

(rats) 
ROlHL-22883-01 
ROlHL-23593-01 

secretion (rats) 



Lung epithelial cell interactions in vitro 
Mast cell granules-Structure and 



BIOLOGICAL TRANSPORT, SECRETORY 
MECHANISMS, EXCRETION 

P50HL-14164-07 0037 A/S SCOR -Comparative and 

experimental atherosclerosis - Genetic control of plasma 

cholesterol -Interaction of dietary fatty acid (monkey) 
POlHL-14388-07 0225 Regulation of the circulation in 

pathological states - Release of renal prostaglandins by 

saluretic-diuretic agents (dogs) 
ROlHL-14720-08 Factors governing the renal excretion of 

acid (humans, rats) 
ROlHL-14844-06 Mucous glycoprotein in human respiratory 

epithelium (also wheat) 
ROlHL-19008-02 Carbon dioxide diffusion in lung and 

muscle tissues (dogs) 
ROlHL-19366-03 Renal Starling forces in experimental 

conditions (rats, rabbits) 



32 

BIOLOGICAL TRANSPORT, TRANSPORT 
EFFECTORS 

SEE ALSO BIOLOGICAL TRANSPORT, ION EXCHANGE AND 
TRANSPORT, ION CARRIERS (lONOPHORES) 

SEE ALSO BIOLOGICAL TRANSPORT, TRANSPORT PROTEINS 
(SEE ALSO SPECIFICS) 
" POlHL-063 12-17 0034 Surgical cardiology - Metabolic 

factors in cardiac function -Creatine phosphate depletion 

(animals) 
ROIHL 13029-09 Metabolic regulation of sugar transport 

(pigeons, rats) 
POlHL-14388-07 0191 Regulation of the circulation In 

pathological states - Regulation of chloride transport in 

epithelial membranes (turtles) 
ROlHL-16454-03 Vascular muscle reactivity in 

hypertension (human, rats) 
ROlHL-17452-04 Depolarization induced cardiac 

automaticity (human, animals) 
ROlHL-18003-05 Digitalis -Mechanism and reversal studies 

(dog, sheep, duck, guinea pig, human) 
ROlHL-19733-03 

lungs (rabbits) 
** ROlHL-20308-02 



Absorption of antigen through inflamed 
Regulation of myocardial acylcarnitlne 



transport (rats) 
ROlHL-207 11-01 Structure-function relationships in red 

cell NA-K pumps (goats) 
ROlHL-22444-01 Bronchial mucus production in organ 

culture (human) 
R01HL-22568-01 pH effect in heart cells -Influence of 

cardiac drugs (tissue culture, rats) 
R23HL-22882-01 Modulation by disease of effect of 

furosemide in man 
ROlHL-23161-01 0002 Biology of myocardial ischemia - 

Palmitylcarnitine inhibition of ion pumps in myocardial 

ischemia (dog, sheep) 

BIOLOGICAL TRANSPORT, TRANSPORT 
ENERGETICS 

ROlHL-13029-09 Metabolic regulation of sugar transport 

(pigeons, rats) 
P50HL-142 12-07 0013 Correlated studies of pulmonary 

fibrosis - Mechanism of beryllium pathogenicity in the lung 

(human, rabbit, guinea pig) 
** ROlHL-14483-08 Energy conservation in heart 

mitochondria (cattle, E coli, human) 
ROlHL-15622-05 Computer simulation in cardiology (rats, 

dogs) 
ROlHL-158 13-05 Cardiac anoxia -Protective effect of 

carbohydrate (dogs) 
ROlHL-17729-04 

(human) 
ROlHL-20308-02 



Stimulus-response coupling in platelets 
Regulation of myocardial acylcarnitlne 



transport (rats) 
R0IHL-22135-0I Control of calcium fluxes across cardiac 

membranes (dogs, rabbits, guinea pigs) 
ROlHL-23138-01 Myocardial ischemia (dogs, rats, chick 

embryo) 

BIOLOGICAL TRANSPORT, TRANSPORT 
PROTEINS (SEE ALSO SPECIFICS) 

SEE ALSO ENDOCRINOLOGY, HORMONE BINDING PROTEINS 

SEE ALSO HEMOPROTEINS, HAPTOGLOBINS 

SEE ALSO METALLOPROTEINS, CERULOPUSMIN 

SEE ALSO METALLOPROTEINS, FERRITIN 

SEE ALSO METALLOPROTEINS, TRANSFERRIN 

SEE ALSO PORPHYROPROTEINS, METALLOPORPHYROPROTEINS 

SEE ALSO PROTEIN BINDING 

SEE ALSO PROTEINS, Z PROTEIN 
ROlHL-02835-21 Renal transport carrier for organic 

compounds (dogs, rats) 
ROlHL-05360-19 Cholesterol biosynthesis and its control 

in liver (rats) 
** ROlHL-06221-17 Composition and structure of plasma 

lipoproteins (human, turkeys, baboons) 
ROlHL-08634-15 Enzymic cholesterol synthesis (human. 

rats, protozoa, yeast) 
** ROlHL-08893-14 Structure and function of membrane 

proteins (human) 
ROlHL-10933-13 Fat metabolism and atherosclerosis 

(rabbits, cattle, human, rats) 
ROlHL-10940-13 Lipid transport (rabbits, cattle, chickens) 
ROlHL-12085-10 Lipoprotein-carbohydrate metabolism 

(human, rats) 
ROlHL-14483-08 Energy conservation in heart 

mitochondria (cattle, E coli, human) 
ROlHL-15263-06 Lecithin-Cholesterol acetyltransferase 

(human, rabbits) 
ROlHL-15648-06 Lipid metabolism-Transport by lateral 

diffusion (human, rabbit, cattle) 
ROlHL-16628-05 Regulation of lipid metabolism (rats) 
ROlHL-16660-06 Phospholipid-cholesterol and 

phospholipid-protein interactions 
ROlHL-17371-05 Regualtion of cholesteryl ester levels in 

the aorta (swine) 
ROlHL-17463-03 Composition and structure of plasma 

lipoproteins (human, rabbits) 
ROlHL-17879-04 Molecular structure of the ouabain 

sensitive ATPase (dogs) 
ROlHL-18181-04 Surfactant metabolism -Alveolar cells and 

lung disease (mice, rabbits) 
** POlHL-18208-04 0007 Center for the study of blood cell 

rheology - RBC membrane protein (human) 



'Excludes routine methodology OR covers only general projects which preclude indexing at the specific level. 
••Onented significantly to above subject. 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



BIO 

ROlHL-18255-04 Lipid-protein interactions and calcium 

transport (models) 
POlHL-18577-03 0005 Lipoproteins -Cell surface 

interactions - Chemical synthesis of apolipoproteins and 

apoliprotein fragments 
ROlHL-18619-03 Transferrin iron binding and transport 

properties (chicken, rabbit, human) 
ROlHL-18746-02 Chemical studies on proteolipid 

apoproteins (cattle) 
ROlHL-20365-03 Molecular mechanisms of anion transport 
ROlHL-20711-01 Structure-function relationships in red 

cell NA-K pumps (goats) 
ROlHL-20882-02 Interactions of plasma lipoproteins with 

erythrocytes (Rhesus, human) 
" P50HL-21006-02 0003 Specialized center of research in 

arteriosclerosis - Transport of vitamin A in plasma (human 

rat) 
ROlHL-21217-01 Ion and 5-hydroxytryptamine transport by 

platelets 

BIOLOGICAL TRANSPORT, TRANSPORT 
PROTEINS, PERMEASES 

ROIHL- 17 736-04 Metabolic change during cardiac 

ischemia (rats, dogs) 
ROlHL-18818-04 Stereochemical mechanism of sickling of 

hemoglobin S (human) 

BIOLOGICAL TRANSPORT, TRANSPORT 

PROTEINS, PERMEASES, GLUCOSE PERMEASES 

ROlHL-08893-14 Structure and function of membrane 

proteins (human) 
R01HL-13237-09 Erythrocytes during early development 

(human, animals) 

BIOLOGICALS RESOURCES 

SEE BIOLOGICAL PREPARATIONS AND STANDARDIZATION 
SEE IMMUNOLOGICAL PREPARATIONS (GENERAL)(INCLUDING 
CERTIFICATION AND STANDARDIZATION) 

BIOLOGY (GENERAL)* 

SEE ALSO PHOTOBIOLOGY 

SEE ALSO WATER ENVIRONMENT. AQUATIC BIOLOGY 
SEE ALSO WATER ENVIRONMENT. MARINE BIOLOGY 
** POlHL-20993-02 0009 Population dynamics of arterial 
cells in atherogenesis - Mathematical biology-Core 
R13HL-22068-01 Conference on The Internal Environment' 
(California) 

BIOLOGY, LIFE CYCLE 

ROlHL-18629-04 Influence of aging and hypertension on 
the myocardium (rats) 

BIOLOGY, POLYMORPHISM 

P01HL-03174-23 0006 Mechanisms of acute vascular 

reaction to injury - Atherosclerotic plaque studies using 

mosaic analysis (human) 
ROlHL-04366-19 Plasminogen-Activation and structure- 
function relations (mammals, birds) 
P01HL-09011-15 0001 A research and resource program 

in blood - Genetic markers of human blood and gene 

mapping (human) 
POlHL-0901 1-15 0012 A research and resource program 

in blood - Theoretical population genetics (human) 
ROlHL-15808-06 Role of angiotensinogen in hypertension 

and stroke (human, rabbits) 
ROlHL-17194-03 Comparison of two inherited forms of 

alpha-1-antitrypsin (human) 
P60HL-17265-04 0008 Community blood resource center 

support - Research-Blood genetic markers as biological 

probes (human) 
POlHL-17419-04 0001 Studies on mechanisms of 

hemostasis - Structure and metabolism of fibrinogen 

(human) 
R01HL-1788M5 Biosynthesis and degradation of blood 

group substances (human, animals) 
ROlHL-18612-03 Thin filament control of heart contraction 

(cattle) 
** POlHL-21016-02 0008 Sickle cell anemia and other 

hemoglobinopathies - The clinical variations of sickle cell 

anemia 
** ROlHL-21665-01 Collagen polymorphism and arterial 

structure (monkeys, guinea pigs) 
R23HL-22799-01 Interaction of the complement and 

coagulation systems (monkeys) 
** ROlHL-23194-02 Genetics of hypertension and associated 

variables (human) 

BIOLOGY, SYSTEAAATIC 

SEE ALSO MICROBIAL IDENTIFICATION AND CLASSIFICATION 
(TECHNIQUES) 
P01HL-08214-15 0048 Chemical and biological properties 
of lipids - Lipids in microorganisms and plants 

BIOLOGY, SYSTEMATIC, EVOLUTION AND 
PHYLOGENY 

R01HL-02254-23 Blood coagulation and hemorrhagic 

disease (human, animals) 
ROlHL-02751-21 Function and metabolism of serum 

albumin (mammals, fish, amphibians) 
ROlHL-06950-17 Red cell metabolism (human, 
vertebrates) 
** ROlHL-07047-16 Comparative study of cardiac conduction 
system (human, birds, mammals) 

(contd) 



•lO 

ROIHl 08?99 16 Moleculm bioloiy ol htmerylhitn and 

htinocyaniii (invtrtabralas) 
ROIMI 12486 10 Strucluri lunclion coiiolntion in tho 

ttfiuin (tibbits) 
ROIHL IMD7 0S P«iiphttil Cdculation and lluid balance 

(tish. mammals, human) 
ROIHI 18082 03 Irythrocyl* phosphates and vettebiale 

(as tianspoit (amphibians, leptiles) 
" ROIHI 18868 03 Development ol veitebiale vasculai 

contiol systems (irpliles. amphibians) 
ROIHL 20800 1/ Neuial basis ol lespiiatory and 

vasomotoi activity (cats) 
" ROIHL 20961 02 H«mo|lobin Y chain genes Evolution and 

inducibility (monkeys, human) 

BIOLOGY, SYSTEMATIC, EVOLUTION 
BIOCHEMICAL 

ROIHL 02212 23 Coagulation ol bluod (human) 
ROIHL 04366 19 Plasminogen Activation and structure 

lunction relations (mammals, birds) 
ROIHL 05556 19 Proteins, lipoproteins Structure and 

reactivity (chicken, human, diving mammals) 
ROIHL 06221 17 Composition and structure ol plasma 

lipoproteins (human, turkeys, baboons) 
ROIHL 10642 18 Plasma cholesterol metabolism (human, 

macaca) 
ROIHL 15026 12 Quantitative genetic control ol protein 

synthesis (human, primates, mammals) 
ROIHL 1546006 Molecular adaptation Hemoglobin 
systems ol lish (marine) 
BIOLOGY, SYSTEMATIC, GENETIC STRAINS 
POlHL-06835 17 0018 Cardiovascular disease Fatty 

acid concentration (rats) 
POIHL 06835 17 0019 Cardiovascular disease Fatty 
acid distribution (rats) 
•* ROIHL 10942 09 Study ol genetic hypertension in rats 
P50HL14164 07 0027 A/S SCOR- Comparative and 

experimental atherosclerosis Hyper- and 
hyporesponsiveness to dietary cholesterol (squirrel monkey) 
P50HL-1416407 0028 A7S SCOR -Comparative and 
experimental atherosclerosis Hyper- and 
hyporesponsiveness to dietary cholesterol (Alrican green 
monkey) 
*• P50HL-1416407 0029 A/S SCOR -Comparative and 
experimental atherosclerosis - Development ol pigeon 
substrains 
** P50HL-14164-07 0037 A/S SCOR-Comparative and 

experimental atherosclerosis - Genetic control ol plasma 
cholesterol -Interaction ol dietary tatty acid (monkey) 
P50HL-14164 07 0044 A/S SCOR -Comparative and 
experimental atherosclerosis - Cell biology-atherosclerosis 
project (pigeons) 
P50HL-14236-05 0005 Prevention ol premature 

arteriosclerosis ■ Genetically hyperlipidemic and 
hypolipidemic rats 
** ROlHL-1491306 Hypeilension -Genetic inlluence ol kidney 
(rats) 
POlHL-1683304 0014 Hemoglobin and red cell system in 

hemoglobinopathies - Erythrocyte membrane damage in Hb 
SS disease (human) 
POlHL-17430-05 0001 Control ol coagulation - Porcine 

von Willebrand's disease 
ROlHL-1 7754-03 Pathogenesis and prevention ol 

hypertension sequelae (rats) 
ROlHL-18191-04 Models ol hypoxic pulmonary 

hypertension (cattle, minipigs) 
POlHL-18576-03 0009 Thrombosis research program 
project ■ Biology ol factor VII (human, rabbits, cattle) 
POlHL-1864603 0003 Studies basic to heart 

transplantation - Host responses to xenografts (rodents, 
rabbits) 
ROlHL-18723-03 Genetic heterogeneity ol acid lipase-- 

Atherosclerosis (human) 
ROlHL-18831-03 Microscopy ol spontaneously hypertensive 

arterial lesion (rats) 
ROlHL-18848-03 Etiology and development ol congenital 

heart disease (dogs, cats) 
R01HL-19027-03 Calcium and cyclic AMP in causation ol 
hypertension (rats) 
** P50HL-19362-02 0004 A/S SCOR-Atherosclerosls in 
nonhuman primates - Selective breeding for characters 
related to atherosclerosis (baboons) 
P50HL-19362-02 0012 A/S SCOR -Atherosclerosis in 

nonhuman primates - Induction of chronic hypertension by 
salt loading (baboon) 
** ROlHL-20176-02 Biochemistry and genetics of salt 
hypertension (rats) 
ROlHL-20201-01 Hypertension and vascular steroid 

receptors (rats) 
ROlHL-2044602 
(also rats) 
M ROlHL-20572-02 

hypertension 
** ROlHL-20572-02 0001 Hemodynamic relations to 

metabolism in hypertension - Hemodynamic and myocardial 
functional studies in the SHR (rat) 
ROlHL-20861-01 Cardio-respiratory-renal stress reactions 

(dogs) 
ROlHL-22603-01 Trace metals, vascular activity and 
hypertension (rats) 
** R23HL-22959-01 Heart development in inherited 
cardiomyopathy (hamsters) 



NOIHV 62905 02 
iiitfiiioM:lero^i\ 



33 



Noil hiiiiijin piimaln models of 



Autonomic neuropathy in diabetic mice 
Hemodynamic relations to metabolism in 



BIOLOGY, SYSTEMATIC, SPECIES 

ROim 019/9 22 ArterioscleiOMS in loo «nim«K on 

conliolled diets (animiiK) 
POIHI 031 /4 23 000/ Mechanisms ol acute vascular 

reaction to injuiy Hiviling ol miured myocardium Basal 
lamina scallold (hum.in. lats. dogs) 
POIHL 031 74 ?3 001 1 Mechanisms ol acute vascular 

reaction to injury Mutagen metabolism by artery vnall in 
etiology ol atherosclerosis (human, animals) 
POIHL 06285 18 0203 Cardiovascular respiratory 

physiology and biochemistry Pathways ol lipid transport 
in the blood (animals) 
P01HL06835 17 0030 Cardiovascular disease Synthesis 

and pharmacology ol angiotensin antagonists (rats, cats) 
POIHL 07896 15 0033 Environmental biomedical research 

program Breathing mechanism in birds 
*• POIHL 089 74 14 0024 Natural and experimental 

atherosclerosis Atherosclerosis, sterol and lipoprotein 
metabolism in nonhuman primates 
ROIHL 10612 13 0019 Humoral factors in heart lailure 

and hypertension Pathogenesis ol hypertension in the 
spontaneous hypertensive rat 
POIHL 11351 12 0023 Cellular and molecular 

mechanisms of myocardial lunction Energetics ol 
mammalian muscle (rats) 
** ROIHL 11906 11 Comparative study ol heart lunction 
(cats, rats, hedgehogs, squirrels) 
POIHL 14580-07 0001 Program project in respiratory 

mechanics Micromechanics ol the lung (dogs, rats) 
ROIHL 15026-12 Quantitative genetic control of protein 

synthesis (human, primates, mammals) 
ROIHL 15522-06 Influence ol mannitol on ischemia 

cardiac muscle (dogs, cats, rats) 
ROIHL 15797-05 Lipid metabolism and atherosclerosis in 
primates (monkeys, human, squirrels) 
** ROlHL-15888-05 Comparative stereology ol the 
myocardium (birds, mammals) 
ROIHL 16119-05 Spleen and marrow allografts in 

hereditary anemia (mice) 
POlHL-16137 05 0001 Alveolar biology - Chemical 

characterization of surfactant system -Lipid and lipid 
protein fractions 
POIHL 16137 05 0008 Alveolar biology - Macromolecular 
events in pulmonary cells in toxic environments (animals) 
POlHL-16607-05 0003 Calcium ion and control of 
cardiovascular function - Calcium transport in 
sarcoplasmic membranes (animals) 
POlHL-16833-04 0016 Hemoglobin and red cell system in 
hemoglobinopathies - Calcium-indiced membrane damage 
in Hb SS disease (human, animals) 
ROlHL-16860-05 Mossbauer studies of respiratory 

hemoproteins 
ROlHL-17322-04 Functional characteristics of smooth 

muscle isolated from lung (animals) 
POlHL-17430-05 0007 Control ol coagulation - Platelet 
adhesion, aggregation, ultrasfructure in flowing blood 
(human, animals) 
ROlHL-1756703 Lipoprotein-cytolytic toxin interaction 

(Staphylococcus aureus, mammals, human) 
POlHL-17731-04 0003 Physiological basis of pulmonary 

disease ■ Comparative physiology (vertebrates) 
** ROlHL-17758-04 Development ol collateral ventilation 
(dogs, fish, horses) 
R01HL-17947-04 Experimental renal and neurogenic 

hypertension (human, animals) 
ROlHL-17954-03 Narcotics and the circulation (human, 

dogs, pigs, monkeys) 
ROlHL-18070-04 Regulation of intrapulmonary airways 

and vessels (human, animals) 
ROlHL-1822604 Mechanism of oxygen supply to tissue 

(human, animals) 
POlHL-18574-03 0006 Lipoprotein methodology and 
biomedical applications - Lipoprotein transformation, 
lipolytic enzymes, diet and lipid lowering agents 
POlHL-18646-03 0003 Studies basic to heart 
transplantation - Host responses to xenografts (rodents, 
rabbits) 
P50HL-19362-02 0005 A/S SCOR-Atherosclerosis in 

nonhuman primates - Hybridization to produce primate 
model of atherosclerosis (baboon. Rhesus) 
POlHL-19717-02 0001 Response of the lung to injury - 

Lung elastic tissue (animals) 
ROlHL-20206-02 Carbohydrates-nucleotides and adrenergic 

interactions (rabbits, cats, rats) 
ROlHL-2035202 Defenses of lung cells against oxygen 

toxicity (human, animals) 
POlHL-20984-02 0005 Cellular mechanisms in cardiac 

hypertrophy - Neurohumoral receptors in cardiac growth 
and compensatory hypertrophy (animals) 
ROlHL-21032-02 Injury, wall thickness, and arterial wall 

oxygenation (dogs, rabbits) 
ROlHL-21308-01 Prostaglandins and local control of the 

circulation (rats, dogs) 
ROlHL-21850-01 Calcium transport in the hypertrophied 

myocardium (rats, animals) 
R01HL-22079-0I Heart receptor sites for digitalis and 

steroid hormones (animals) 
ROlHL-22500-01 Conversion of choline to 
phosphatidylcholine in lung (rabbits, pigs) 



POIHI 72619 01 0001 Cellular mwhanismt ol h»il 

lllluct C«ll membrani itolilion and ixon-.lilution IHnf. 
Iimbi) 

BIOMATERIALS 

Ml Al'.O HKJMI DICAl [NClNEfRINC, BIOtOCICAl P(JW(H 

SrSMMS 
Sff AlSOttlOOn COAtiUIAIION ANIIIHROMBOCf NIC 

StlRIAtl 
SEE Also PROSIHfSI', 
SEE ALSO SUHGICAl ADHESIVE "> 

SEE ALSO TISSUE COMPATIBILIIY IRANSPUNl. IMI'IANI 
POIHL 0631? 1/ 0030 Surgical cardiology Total 

artificial heart (calves) 
•• POIHI 0631? 1/ 0043 Surgical cardiology The 

cylindrical ventricular assist device (dogi) 
*• POIHL 06370 1/ 0013 Cardiopulmonary and renal 

pathology research center Morphologic analysis ol 
vascular prosthesis (human, dogs) 
POIHL 11414 11 0027 Thrombosis and atherosclerosil 

program Thermal memory wire lilter to prevent pulmonary 
embolism (human, dogs) 
ROIHL 11418 09 Poly diaminophosphazenes 
ROIHL 11945 10 Synthesis ol artilicial lung and kidney 

systems (sheep, mice, swine) 
POIHL 12373 10 0003 Cardiopulmonary physiology and 

pathophysiology Myocardial function in man 
ROIHL 12839 09 Flow, transport and membrane 
phenomena in blood (human) 
M POIHL 13330 08 Mechanical circulatory support 

POIHL 1333008 0031 Mechanical circulatory support - 

Hemodynamics ol cardiac prosthesis 
POIHL 13330 08 0034 Mechanical circulatory support In 

VIVO test and evaluation ol left ventricular bypass pumps 
(human, cattle) 
** POIHL 1333008 0056 Mechanical circulatory support 

Blood compatibility linings (calves) 
POlHL-13330-08 0059 Mechanical circulatory support 

Physiologic evaluation of circulatory assistance (cattle) 
** POIHL 13330-08 0062 Mechanical circulatory support - 

CORE facilities 
ROlHL-13426 09 Left ventricular bypass for myocardial 
infarction (cattle, human) 
** POlHL-13737-07 0002 Assisted circulation - U-shaped 
mechanical auxiliary ventricle (dogs) 
POlHL-13737-07 0005 Assisted circulation - Piezoelectric 

assist device (animals) 
POIHL 13737 07 0026 Assisted circulation - Hemostatic 

mechanism (human, dogs) 
POlHL-13737-07 0032 Assisted circulation ■ The dynamic 

aortic patch (human, dogs) 
POlHL-13737-07 0033 Assisted circulation - Autologous 
bioprosthetic grafts for coronary artery bypass surgery 
(human, dogs) 
M POlHL-13738-08 Cardiac assist devices and artificial 
hearts 
POlHL-13738-08 0002 Cardiac assist devices and 
artificial hearts - Total replacement with artificial heart 
(calves, sheep, ponies) 
** POlHL-13738-08 0003 Cardiac assist devices and 

artificial hearts - Pathophysiological effects of the artificial 
heart (calves) 
** POlHL-13738-08 0004 Cardiac assist devices and 
artificial hearts - Hematological evaluation of prosthetic 
materials (calves) 
** POlHL-13738-08 0005 Cardiac assist devices and 
artilicial hearts ■ Development of new materials for 
artificial heart and assist devices (sheep, dog) 
** ROlHL-13803-07 Advanced cardiac valvular and vascular 
prosthesis (dogs, baboons) 
ROlHL-13988-07 Elimination of reoperative cardiac 

pacemaker surgery (dogs) 
R01HL14126-17 Effect of function on grafts and implants 
of collagen (dogs, monkeys) 
M POlHL-15195-04 Program project in biological materials 
** POlHL-15195-04 0001 Program project in biological 

materials - Design and synthesis 
** POlHL-15195-04 0002 Program project in biological 

materials - Structural and surface characterization 
** P01HL15195-04 0003 Program project in biological 

materials ■ Mechanical evaluation and fabrication 
** POlHL-15195-04 0004 Program project in biological 

materials - Biological evaluation and surface interaction 
studies (dogs) 
** POlHL-1548606 0004 Studies on thrombosis ■ 

Thrombosis, intravascuair coagulation, platelet aggregation 
(dogs) 
ROlHL-15668-06 Extracorporeal respiratory gas exchange- 

A new approach (dogs) 
R01HL16154-05 Membrane lung perfusion for acute 

respiratory failure (sheep, baboons) 
POlHL-16387-04 0006 The blood vessel and 

thrombogenesis - Mechanism of delayed vessel graft lailure 
(dogs, rabbits) 
ROlHL-16582-05 
" ROlHL-16921-05 
materials 
ROlHL-17369-04 

metabolism (monkeys) 
POIHLI 7430-05 0007 Control ol coagulation - Platelet 

adhesion, aggregation, ultrastructure in flowing blood 
(human, animals) 

(contd) 



Artificial lungs (dogs) 

Synthetic hydrogels as blood tolerable 

Arterial bypass surgery-Structure and 



•Excludes routine meltiodology OR covers only general projects wtiich preclude indexing at the specific level. 
••Oriented significantly to above subject. 



M Grant has subprojects descnbing specillc research aspects. 
See Appendix lor investigator's name and grant number. 



BIO 



Artificial heart and related problems 



R01HL-17623-0S Initial events in thrombus formation on 

surfaces (humana rats) 
R01HL17969-04 Function and structure of semilunar 

valves (dogs) 
R01HL18084-03 

(calves) 
ROlHL-18321-03 Fluid shear or magnetic alignment of 

blood components (human) 
ROlHL-18441-03 Guidelines for polymers acting as elastin 

substitutes 
POlHL-18576-03 0003 Thrombosis research program 

project - Biocompatible materials 
P01HL18576-03 0010 Thrombosis research program 

project - Evaluation of non-thrombogenic materials (cattle) 
ROIHL 1864403 Prosthesis for aortocoronary bypass 

(dogs, baboons) 
ROlHL-18764-03 Biosorbable thromboresistant surfaces 

(dogs, rats, swine, human) 
R01HL'190S5-03 Platelet function during extracorporeal 

perfusion (human, mammals) 
ROlHL-19173-03 Analysis of blood trauma from 

microporous oxygenators (human, dogs, rabbits) 
ROlHL-19350-02 Prevention of thrombosis by applied 

electric fields (sheep) 
ROIHL- 194 19-03 Cellular interactions with foreign 

materials (mammals) 
R01HL-2O037-O2 Left ventricular-aortic bypass and 

composite prosthesis (sheep, swine, cattle) 
R01HL-20073-02 Blood compatible materials by fluid 

perfusion (human, dogs) 
ROlHL-20079-02 Thromboresistant material 
ROlHL-20079-02 0002 Thromboresistant material - 

Thromboresistant materials (sheep) 
ROlHL-20079-02 0003 Thromboresistant material - Blood 

surface interactions (human, cattle) 
ROlHL-20163-02 Competitive coronary flow in native and 

graft vessels (dog) 
ROlHL-20251-02 A novel approach to nonthrombogenic 

polymer surfaces (sheep, cattle) 
ROlHL-20313-02 Surface-induced thrombosis-Modification 

of albumin variants (human, goat) 
ROlflL-203 56-02 Development and evaluation of an 

artificial heart (calves) 
ROlHL-20554-02 Memory-alloy-filters for venous emboli 

(dogs) 
ROlHL-21001-01 

vascular grafts 
ROlHL-2 1194-02 

biomaterials 
R23HL-21271-02 Extracorporeal circulation and protein 

denaturatlon (human) 
R01HL-21632-02 Development of a transcutaneous power 

transfer system (cattle) 
R23f4L-21805-Cl Tissue cell Interactions with vascular 

prostheses (human, rats, mice) 
R01HL-22I 10-02 Healing complications in vascular 

grafting (dogs) 
POlHL-22163 01 Surface thrombogenesis -Mechanisms and 

prevention 
POlHL-22163-01 0001 Surface thrombogenesis- 

Mechanisms and prevention - Initial blood protein and 

platelet interactions with biomaterials (baboons) 
POlHL-22163-01 0002 Surface thrombogenesis - 

Mechanisms and prevention - Laser-scattering detection of 

microemboli in blood flow (baboons) 
POlHL-22163-01 0003 Surface thrombogenesis - 

Mechanisms and prevention ■ In vivo mechanisms of 

biomaterial thrombogenesis and its prevention (baboons) 
POlHL-22163-01 9001 Surface thrombogenesis - 

Mechanisms and prevention - Polymers for studing blood- 
material interactions core 
ROlHL-22338-01 Platelet adhesion and aggregation in a 

flow chamber (human) 
ROIHL-22455-01 Platelet concentration in the marginal 

layer (dogs, human) 
R01HL-22585-01 Plasma proteins adsorbed to artificial 

organs (human, rabbits) 
ROlHL-23899-01 Flow and flexing at blood/biomaterial 

interfaces 
N01HV-12017-15 Fabrication of grafted hydrogel coatings 

for plastic heart assist devices 
NOlHV-12054-14 Development of intimal linings (human, 

cattle) 
NOlHV-12065-16 Fabrication of implantable artificial heart 

devices (animals) 
NOlHV-32913-11 Study electrodeless glow discharge for 

modifying polymer surface 
N01HV-32917-08 Materials development and testing 
NOlHV-32919-12 Material development and testing 

heparinization processes 



Protein and thrombus deposition on 
Development of antithrombogenic plastic 



NOlHV-32949-11 

medical devices 
NOlHV-3295008 
NOlHV-32953-10 
NOlHV-32959-10 

devices 
NOlHV-4291413 

(cattle) 
NOlHV-42928-07 Continued development of carbon film 

deposits for prosthetics 
N01HV42960-07 Development and evaluation of cardiac 

prostheses (calves) 



Modification of silicon elastomers for 

Blood compatible poly-electrolytes 
Materials compatible with blood (dogs) 
Development of materials for heart assist 

Solenoid left ventricular assist system 



34 



NOlHV-42961-Oe Evaluation of biomaterials in contact 

with blood (dogs) 
NOlHV-42969 06 Interactions of natural and chemically 

modified biopolymers with blood (dogs) 
NOlHV-629 11-04 Vena cava ring tests of biomaterials In 

dogs 

Test polymers for circulatory assist 



NOlHV-729 18-01 

devices 
NOlHV-72919-01 

divices 
NOlHV-72933-01 



Test polymers for circulatoiy assist 



Electrical energy transmission technique 

development (dogs) 
NOlHV-72934-01 Development of a left heart assist blood 

pumps (human, cattle) 
NOIHV 72937-00 Left heart assist blood pumps (calves) 
NOlHV-72938-01 Development of a left heart assist blood 

pump 
NOlHV-72939-01 Develop and evaluate left heart assist 

blood pumps (human, calves, pigs) 

BIOMATERIALS, TISSUE SUPPORTING FRAMES 

** POlHL-13330-08 0056 Mechanical circulatory support - 

Blood compatibility linings (calves) 
POlHL-13737 07 0032 Assisted circulation The dynamic 

aortic patch (human, dogs) 
POIHL 13738-08 0001 Cardiac assist devices and 

artificial hearts - Cardiac assist devices (human, sheep) 
*• POlHL-13738-08 0005 Cardiac assist devices and 

artificial hearts - Development of new materials for 

artificial heart and assist devices (sheep, dog) 
R01HL16582-05 Artificial lungs (dogs) 
ROlHL-18644-03 Prosthesis for aortocoronaiv bypass 

(dogs, baboons) 
ROlHL-18764-03 Biosorbable thromboresistant surfaces 

(dogs, rats, swine, human) 
ROlHL-221 10-02 Healing complications in vascular 

grafting (dogs) 
POlHL-22163-01 0003 Surface thrombogenesis - 

Mechanisms and prevention - In vivo mechanisms of 

biomaterial thrombogenesis and its prevention (baboons) 
ROlHL'23542-01 Pulmonary vascular smooth muscle cell 

dynamics (rat, rabbit) 
** NOlHV'12054-14 Development of intimal linings (human, 

cattle) 
** NOlHV-12060-18 Tissue cultured endothelium for vascular 

prosthetic devices (human, animals) 
NOlHV-72934-01 Development of a left heart assist blood 

pumps (human, cattle) 
NOlHV-72939-01 Develop and evaluate left heart assist 

blood pumps (human, calves, pigs) 
** NOlHV-81388-20 Microfiber substrate for growth of intimal 

linings in circulatory assist devices 

BIOMATHEMATICAL AND COMPUTER SCIENCES 
STUDY SECTION 

SEE COMPUTER AND BIOMATHEMATICAL SCIENCES STUDY 
SECTION 

BIOMATHEMATICS 

SEE MATHEMATICS, BIOMATHEMATICS (GENERAL) 
BIOMECHANICS 

SEE BIOPHYSICS. BIOMECHANICS 
BIOMEDICAL DATA COMPUTER PROCESSING 

SEE BIOMEDICAL SYSTEMS AUTOMATED. COMPUTER 
PROCESSING OF LABORATORY DATA (GENERAL) 

BIOMEDICAL ECONOMICS 

SEE HEALTH ECONOMICS 

BIOMEDICAL EDUCATION 

SEE EDUCATION. HEALTH OCCUPATIONS 

BIOMEDICAL ENGINEERING 

SEE ALSO BIOPHYSICS (GENERAL)* 
M POlHL-1 1307-12 Biophysical studies in pediatric 

cardiology 
** POIHLI 1307-12 9002 Biophysical studies in pediatric 

cardiology - Biomedical engineering 
** ROlHL-12493-10 Bioengineering analysis of microvascular 

function (cats, rabbits) 
POlHL-13737-07 0025 Assisted circulation - Driving 

system based on quantitative criteria (human, dogs) 
** POlHL-14985-07 0018 Adaptation to hypoxia ■ 

Bioengineering core 
ROIHL-17821-03 Cavitation phenomena near prosthetic 

devices 
** ROlHL-19350-02 Prevention of thrombosis by applied 

electric fields (sheep) 



M 



ROlHL-20079-02 
R01HL-20219C2 

(rats) 
ROIHL 21188-02 

desquamation 
NOlHV-72933-01 



Thromboresistant material 
Cryopreservation of the isolated heart 

Pulsatory water flux and endothelial cell 

Electrical energy transmission technique 



development (dogs) 

BIOMEDICAL ENGINEERING, BIOLOGICAL 
POWER SYSTEMS 

POlHL-10436-13 0006 A multidisclplinary study of 
congenital heart disease - Ventricular blood pumps and 
valves (human, cattle) 
** ROlHL-13988 07 Elimination of reoperative cardiac 
pacemaker surgery (dogs) 



BIO 

ROlHL-18084-03 Artificial heart and related problems 

(calves) 
R01HL-2035e-02 Development and evaluation of an 

artificial heart (calves) 

Catheter ventricular defibrillation studies 



Signal analysis of turbulence study In 



** ROlHL-20629-02 

(dogs) 
ROlHL-2083502 

blood 
** ROlHL-21632-02 Development of a transcutaneous power 

transfer system (cattle) 
ROlHL-2167401 Development of automatic implanted 

defibrillator (dogs, cattle) 
** NOlHV-72971-01 Energy converters to control heart assist 

devices (human, cattle) 
** NOlHV-72976-02 Energy converters to control heart assist 

devices (human, cattle) 
** NOlHV-82919-00 Development of percutaneous energy 

transmission systems 

BIOMEDICAL ENGINEERING, INSTRUMENTATION 
CENTERS 

** ROlHL'11119-17 Amino acid analyzer for biochemical 

research 
** P01HL11414-11 0036 Thrombosis and atherosclerosis 

program - Electron microscopy core facility 
POlHL-12373-10 0018 Cardiopulmonary physiology and 

pathophysiology - Biochemistry laboratory 
** POlHL-12373-10 0019 Cardiopulmonary physiology and 

pathophysiology - Free ranging animal facility 
ROlHL-20356-02 Development and evaluation of an 

artificial heart (calves) 

BIOMEDICAL ENGINEERING, INSTRUMENTATION 
CLINICAUY ORIENTED 

NOlHB-22922-08 Develop effective therapy for sickle cell 

disease (human, dogs) 
** N01HB-e2962-02 Red cell distributions in cyanate-treated 

blood (human, sheep) 
ROlHL-03181-21 0020 Hemodynamics as applied to 

surgical problems - Blood flow measurement -Cardiac 

output and regional flows (dogs) 
** ROlHL-04651-19 Remote stimulation by radio-frequency 

transmission (dogs, human) 
M POlHL-04664-18 Cardiovascular and lung dynamics 
** POlHL-04664-18 0001 Cardiovascular and lung dynamics 

- X-ray projection image videodensitometry (dogs) 

" P01HL-04e64-18 0002 Cardiovascular and lung dynamics 

- X-ray cross section imaging of organs (dogs) 

** POlHL-04664-18 0003 Cardiovascular and lung dynamics 

- X-ray projection image videometry (human, dogs) 

** POlHL-04664-18 0004 Cardiovascular and lung dynamics 

- X-ray cross section imaging of the circulation (dogs) 

** POlHL-04664-18 0005 Cardiovascular and lung dynamics 

- Applications of current research, equipment and 
techniques 

** POIHL-04664-18 0006 Cardiovascular and lung dynamics 

- Cross section imaging of organ functions using emitted 
radiation (dogs) 

" POlHL-04664-18 0007 Cardiovascular and lung dynamics 

- Development and application of ultrasound imaging 
techniques 

** P01HL04664-18 0008 Cardiovascular and lung dynamics 

- Micrographic video imaging technique 

** P01HL04664-18 0009 Cardiovascular and lung dynamics 

- Biological signal and image processing techniques (dogs) 
** POlHL-0466418 0010 Cardiovascular and lung dynamics 

- Left ventricular dynamics (human) 

POlHL-04664-18 0015 Cardiovascular and lung dynamics 

- Computer system for the cardiovascular laboratory 
** ROlHL-04666-19 Artificially paced hearts-Technology, 

physiology (human, dogs) 
P01HL-06285-18 0146 Cardiovascular-respiratory 

physiology and biochemistry - Pathogenesis and detection 

of hypoxic pulmonary edema (human, animals) 
** POlHL-06308-18 0012 Mechanisms and therapy of 

circulatory disease - Echocardiographic evaluation of 

hemodynamics of arrhythmia (human) 
** POlHL-06308-18 0042 Mechanisms and therapy of 

circulatory disease - Echocardiographic assessment of 

arrhythmias-Myocardial tissue type (human, dogs) 
** POlHL-06308-18 0043 Mechanisms and therapy of 

circulatory disease - Exercise and echocardiographic 

examining techniques (human) 
** POlHL-06308-18 0044 Mechanisms and therapy of 

circulatory disease - Echocardiography to determine site of 

ectopic impulse formation (human, dogs) 
" POlHL-06312-17 0030 Surgical cardiology - Total 

artificial heart (calves) 
** POlHL-06312-17 0041 Surgical cardiology - A 

servomechanism for left ventricular assist (human, dogs, 

sheep) 
P01HL06314-17 0065 Immunologic mechanisms in 

cardiovascular disease - Transplantation biology and 

clinical transplantation 
M POlHL-07293-17 Non-invasive cardiovascular 

measurements 
** POlHL-07293-17 0041 Non-invasive cardiovascular 

measurements - Ventricular volumes and dimensions 

(human) 
" POlHL-07293-17 0042 Non-invasive cardiovascular 

measurements - Ventricular imaging software (human) 

(contd) 



*E>cludes routine methodok)gy OR cavers only general projects which preclude indexing at the specific level. 
"Oiioited significantly to above subject. 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



BIO 



* POIHLO??93 W 0043 Non Invislv* cardlovajcultr 

metsuranitnis (CHO Oopplir instruniinlalion loi caidiac 
maasuftmanti (human) 

* POIHI 07293 U 0044 Non mvasiwa caidiovasculai 

maasuramenti Cardiac dupla> scannai 

* PO1H107293 W 004S Non invasiva caid(ovasculai 

maasuicmanls Cardiac scannar transducai position 
locatini systams (human) 

* POIHI 07293 17 0046 Non invasive cardiovascular 

measuramenis Cardiac scanner signal processors 

* POIHI 07293 17 0047 Non invasive cardiovascular 

measurements Cardiac scanner system software 

* P01H107293 17 0048 Noninvasive cardiovascular 

measurements Cardiac scanner recording and display 
systems component 

* POIHL 07293 17 0049 Non invasive cardiovascular 

maasuiements Cardiac scanner engineering evaluation 
and error analysis 
'* POIHL 07293 17 0050 Noninvasive cardiovascular 
measurements Cardiac dimensions measurements 
engineering evaluation and error analysis 
" P01H107293 17 0051 Noninvasive cardiovascular 

measurements Physiologic evaluation of duplex scanner 
(dogs) 
"* P01HL0729J 17 0052 Noninvasive cardiovascular 

measurements Clinical evaluation of the duplex scanner 
(human) 
•* PO1H107293 17 0053 Non invasive cardiovascular 

measurements Clinical evaluation of cardiac dimensions 
using the duplex scanner (human) 
*• POlHL-07293-17 0054 Non-invasive cardiovascular 
measurements Detection of arterial occlusive disease 
(human) 
** PO1HL07293 17 0055 Noninvasive cardiovascular 
measurements Peripheral vascular transducer position 
locating system 
** P01HL0729317 0056 Non invasive cardiovascular 
measurements Peripheral vascular system software 
** POlHL-0729317 0057 Noninvasive cardiovascular 

measurements Peripheral vascular scanner engineering 
evaluation and error analysis (human) 
** POIHL 07293-17 0058 Non-invasive cardiovascular 
measurements ■ Peripheral duplex scanner physiologic 
evaluation 
** POlHL-07293-17 0059 Noninvasive cardiovascular 
measurements - Intracardiac blood flow measurement 
(human) 
ROlHL-07605-16 Congenital heart disease research 

program (human, dogs) 
POlHL-07896-15 0036 Environmental biomedical research 
program - Respiratory heat loss in deep diving (infants, 
dogs) 
P01HL0868215 0006 Regulation of the cardiovascular 
system ■ Cardiovascular studies of mammalian hibernators 
(sciuromorpha) 
POlHL-08805-15 0045 Regulation of ventilation and 
pulmonary circulation - Integrated description of 
neurochemical respiratory control system 
ROlHL-09609-11 Lung volume and breathing mechanics 

during anesthesia (human) 
ROlHL-09711-13 Instantaneous blood (low in ascending 
aorta (human, dogs) 
** R01HL0983112 Effect of resistivity variations on 
electrocardiogram (human) 
R01HL1041712 Multiple systems in electrocardiography 
(human) 
** P01HL10436-13 0006 A multidisciplinary study of 
congenital heart disease - Ventricular blood pumps and 
valves (human, cattle) 
** P01HL1131012 0093 l^echanisms of cardiovascular 
disease ■ Multiple dipolc electrocardiogram project (human, 
dogs) 
** POlHL-11310-12 9002 Mechanisms of cardiovascular 
disease ■ Core support-centralized electronic laboratory 
** POlHL-11414-11 0024 Thrombosis and atherosclerosis 
program ■ Radiographic demonstration of small coronary 
arteries (human, dogs) 
** P01HL114I411 0027 Thrombosis and atherosclerosis 
program ■ Thermal memory wire filter to prevent pulmonary 
embolism (human, dogs) 
ROlHL-11717-09 Effect of stenotic obstructions on flow in 
arteries (dogs) 
** ROlHL-1 194510 Synthesis of artificial lung and kidney 

systems (sheep, mice, swine) 
** ROlHL-1230708 Non-surgical treatment of congenital 

heart disease (human, dogs) 
** POlHL-1237310 0003 Cardiopulmonary physiology and 
pathophysiology - Myocardial function in man 
R01HL-1261110 Basic and clinical studies of the ST-T 

deflection (human, dogs) 
R01HL-1271510 Dynamic cardiovascular measurement 
using ultrasound 
** POlHL-12738-10 0123 Physiologic pharmacology and its 
clinical applications - Ventricular assistance and 
preservation (human, dogs) 
POlHL-12738-10 0128 Physiologic pharmacology and Its 
clinical applications ■ Recording electrograms from 
specialized cardiac tissues (human, dogs) 
POlHL-12738-10 0131 Physiologic pharmacology and its 
clinical applications - Evaluation of intracardiac shunts by 
contrast echocardiography (dogs) 



3S 

ROIHI 12839 09 Mow. transport and membrane 

phenumgna in blood (human) 
ROIHI 13036 08 Coronary Ihrombojiiftttcli on 

myociiidium anil in vivo dftnrlion (dogs, monkeys) 
POIHI 13330 08 Mechanical circulatory support 
POIHI 13330 08 00.11 Mechanical circulatory support 

Hemodynamics of cardiac prosthesis 
POIHL 1333008 0034 Mechanical circulatory support In 

VIVO test and evaluation ol lelt ventricular bypass pumps 

(human, cattle) 
POIHL 13330 08 0056 Mechanical circulatory support 

Blood compatibility linings (calves) 
POIHL 13330 08 0059 Mechanical ciiculatory support 

Physiologic evaluation ol circulatory assistance (cattle) 
POIHL 1333008 0062 Mechanical circulatory support 

CORE facilities 
ROIHL 1342609 Left ventricular bypass for myocardial 

infarction (cattle, human) 
POIHL 13737 07 Assisted circulation 
' POIHL 13737 07 0005 Assisted circulation Piezoelectric 

assist device (animals) 
' POIHL 13737 07 0006 Assisted circulation Portable 

driving unit for permanent assist devices (dogs) 
' POIHL 13737 07 0008 Assisted circulation Phase shift 

balloon pumping alternate designs 

• POIHL 1373707 0013 Assisted circulation ■ Incorporation 

of sensors (human, dogs) 

• POIHL 13737 07 0025 Assisted circulation Driving 

system based on quantitative criteria (human, dogs) 
P01HL13737 07 0028 Assisted circulation Clinical 

studies of intraaortic balloon pumping 
POIHL 1373707 0032 Assisted circulation The dynamic 

aortic patch (human, dogs) 
POlHL-1373707 0039 Assisted circulation ■ Computer 

controlled Intraortic balloon pumping 
I P01HL1373808 Cardiac assist devices and artificial 

hearts 

* POIHL 13738-08 0001 Cardiac assist devices and 

artificial hearts Cardiac assist devices (human, sheep) 

* P01HLI373808 0002 Cardiac assist devices and 

artificial hearts Total replacement with artificial heart 
(calves, sheep, ponies) 
ROlHL-1380307 Advanced cardiac valvular and vascular 
prosthesis (dogs, baboons) 

♦ POlHL-13851-16 Cyclotron produced isotopes In biology 

and medicine (human, animals) 

* ROIHL 13988-07 Elimination of reoperative cardiac 

pacemaker surgery (dogs) 
P50HL-1413607 0005 Pulmonary SCOR-Aitways 

obstructive diseases - Radiographic studies of airways 

obstructive disease (human) 
P50HL-14136-07 0017 Pulmonary SCOR-Airways 

obstructive diseases ■ Pediatric airways obstructive disease 



(human) 
P50HL-141 36-07 9002 

obstructive diseases 
P50HL-14136-07 9007 

obstructive diseases 
P50HL-14187-07 0008 



Pulmonary SCOR-Airways 
Physiology core (human, animal) 

Pulmonary SCOR-Airways 
Special facilities core 

Pulmonary SCOR-Chemical 

Pulmonary 



mediators in pulmonary vascular responses 
thromboembolism (dogs, human) 
P50HL14187-07 0016 Pulmonary SCOR-Chemical 
mediators in pulmonary vascular responses - Core 
pathology service (dogs, rabbits, human) 
P50HL142 14-07 0036 Newborn lung center for hyaline 

membrane disease - Core-Blomedlcal engineering 
P50HL1421807 0013 Pulmonary SCOR -Newborn lung 
center ■ Longitudinal study of ROS-Monitoring fetal P02 
and PC02 during labor (human) 
P50HL-142 18-07 0014 Pulmonary SCOR -Newborn lung 
center • Longitudinal study of RDS-Monitoring fetal 
breathing movements (human) 
POlHL-144 14-07 0014 Environmental influences on 
cardiorespiratory and cellular functions - Temperature and 
acid-base status in tissues, cells, and subcellular system 
POlHL-144 14-07 9003 Environmental influences on 
cardiorespiratory and cellular functions - Machine and 
electronics shop -Core facility 
POlHL-14580-07 0005 Program project in respiratory 
mechanics - Development and evaluation of tests of 
pulmonary function (human) 
R01HL14644-05 Optimization diastolic augmentation and 

systolic sink (dogs) 
R01HL14645-07 Blood flow measurement by ultrasonic 

catheter tip methods (human, dogs) 
ROlHL-14688-05 Myocardial assessment by inverse 
electrocardiography (monkey) 
' ROlHL-14785-07 Ultrasonic scattering for tissue 

characterization (dogs, cattle, human) 
' ROlHL-150 15-07 New concepts In cardiac ultrasound 

technology (human) 
' ROlHL-15247-05 Extending the life of Implanted 
pacemakers (dogs, human) 
ROlHL-15270-06 Local mechanical properties of the aortic 

tissue (dogs, pigs) 
ROlHL-1559305 Prolonged extracorporeal cardiopulmonary 

support (rats, sheep, rabbits) 
POlHL-15596-05 0001 Coagulation, fibrinolysis, 

hemostasis and hepatitis ■ Defibrination (human) 
* ROIHL 15668-06 Extracorporeal respiratory gas exchange- 
A new approach (dogs) 



• ROIHI 15/81 06 (iuided v«4(ul»i ublittiition ol (.N", 

vatcuUr lesions (human) 
ROIHI 160/6 06 I krtiophy vokjiiy o( librillalioo and 

dafibrillation (human) 
ROIHI 16154 O'j Membrane lung peflusion lor atutr 

respiratory (allure (sheep, baboons) 

• ROIHL 16260 04 Development of clini(;al cine ullnsound 

cardiography 
'• POIHL 1638/04 0005 The blood vessel and 

Ihrombogenesis Fluid enginaerin| coniidtrations in 
Ihrombogenesis 
'* ROIHI 16484 04 Radiographic ventriculomelry for coronsry 

heart disease (human) 
'• ROIHL 1648/05 Computer controlled two dimensional 

echocardiography 
>* ROIHL 16582 05 Artificilllungi (dogs) 
** ROIHL 16759 05 Ultrasonic measurement of cardiac 
geometry and flow 
ROIHL 16791 03 Computer linkage lor a dual camera 
system 
•* ROIHL 16830 05 Non invasive determination of aortic 
blood velocities (human) 
POIHL 16851 04 0009 Human red cell membrane in 

health and disease Blood cell properties in circulatory 
regulation (dogs, rabbits) 
** ROIHL 16901 05 Multipolar linkage between heart 
geometry and surface (human, dogs) 
ROIHL 1690804 Myocardial function, risk factors and 

future CHO (men) 
ROIHL 1690904 Myocardial (unction, risk (actors and 

(uture CHD (men) 
POIHL 16910 05 0002 Regulation o( the peripheral 

circulation Coronary circulation (dogs) 
P01HL1691005 0005 Regulation of the peripheral 

circulation Control of circulation by baroreceptor and 
chemoreceptor reflexes (dog. monkey) 
P60HL- 17269-04 0026 National heart and blood vessel 
research and demonstration center Dynamics of ischemic 
heart disease (human, dog) 
P60HL- 17269-04 0029 National heart and blood vessel 

research and demonstration center Clinical application of 
circulatory assistance (human) 
** P60HL1726904 0030 National heart and blood vessel 
research and demonstration center Cardiovascular 
engineering laboratories (human) 
" P60HL- 1726904 0032 National heart and blood vessel 
research and demonstration center ■ Clinical circulatory 
assist device fabrication 
M P01HL17421-05 Regulation and exchange In the 

microcirculation 
" P01H11742105 0006 Regulation and exchange in the 
microcirculation - Core facilities -Optical instrumentation 
facility 
** P01HL17421-05 0007 Regulation and exchange in the 
microcirculation - Core facllities-fluorometric measurement 
methods for microcirculation 
M ROlHL-17543-03 Magnetic tracers for diagnosis of lung 

disease 
** ROlHL-17543-03 0001 Magnetic tracers for diagnosis of 
lung disease • Chronic, interstitial lung disease (human, 
rabbits) 
** ROlHL-17591-03 Development of electromagnetic 

rheoanglography (human, dogs) 
** ROIHL- 17604-03 Wearable blood pressure and ECG 
recording system 
P50HL-17648-04 0004 Study of ischemic heart disease - 

Radionuclide imaging studies (human, pig) 
P50HL-1764804 0021 Study of ischemic heart disease ■ 
Biventricular contractile responses to acute myocardial 
infarction (mammals) 
** P50HL-17651-04 0016 Ischemic heart disease specialized 
center of research - Retroperfusion of coronary venus 
circulation with therapeutic agents (dogs) 
** P50HL-17651-04 0023 Ischemic heart disease specialized 
center of research - Development of multipurpose catheter 
for monitoring and electronic pacing 
** P50HL17651-04 0035 Ischemic heart disease specialized 
center of research - Core facillties-Biomedical engineering, 
biophysics 
P50HL-17651-04 0037 Ischemic heart disease specialized 
center of research • Measurement of coronary venous 
outflow by thermodllution (human) 
" P50HL-17651-04 0047 Ischemic heart disease specialized 
center of research ■ Clinical core-Automated arrhythmia 
monitoring system 
P50HL-1765504 0012 Study of ischemic heart disease - 

DATA management 
** P50HL-17665-04 0027 Study of Ischemic heart disease ■ 

Positron Imaging of regional myocardial perfusion (human, 
dog) 
** P50HL17667-04 0030 Study of ischemic heart disease - 

Computerized clinical data acquisition and processing 
" P50HL-17667-04 0042 Study of Ischemic heart disease - 
Core-Central instrumentation and software 
P50HL-1767004 0008 Study of Ischemic heart disease - 

Surgical treatment of cardiac rhythm disorders (human, 
dogs) 
** P50HL-17670-04 0014 Study of Ischemic heart disease - 

Real time ultrasound Imaging In ischemic heart disease 
(human, dog) 

(contd) 



•Excludes routine methodokigy OR covers only general projects which preclude indexing at the specific level. 
••Oriented significantly to above subject. 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



BIO 



Artificial heart and related problems 
Preprocessor system for cardiograms 



P50HL-17682-04 0014 Study of ischemic heart disease - 

Myocardial ischemia-Instrumentation and technique (dogs. 

baboons) 
ROlHL-17769-03 New methods of studying blood 

coagulation kinetics 
ROlHL-17826-04 Oxygen delivery to tissue (rat, dog) 
ROlHL-1793104 Normalized body surface potential maps 

(children) 
ROlHL-17974-03 External pneumatic compression in deep 

venous thrombosis (human) 
R01HL18040-04 Waveform dependency in defibrillation 

(calves) 
R01HL18084-03 

(calves) 
ROlHL-18144-03 

(human) 
ROlHL-1819003 Myocardial blood flov» in acute 

myocardial infarction (human, dogs) 
ROlHL-18256-01 Optical properties of platelets and 

erythrocytes (rabbits, dogs, human) 
R01HL18398-04 Mechanisms of delayed and asymetric 

ventricular conduction (human, dogs) 
ROlHL-18492-03 Measurement of regional coronary flow 

reserve (human, dogs) 
POlHL-1857403 Lipoprotein methodology and biomedical 

applications 
POlHL-18574-03 0001 Lipoprotein methodology and 

biomedical applications - Ultracentrifugal and 

eleclrophoretic lipoprotein methodology -Applications 
POlHL-18576-03 0001 Thrombosis research program 

project - Platelet damage from physical forces and 

artificial surfaces (human) 
ROlHL-18644-03 Prosthesis for aortocoronary bypass 

(dogs, baboons) 
POlHL-18646-03 0010 Studies basic to heart 

transplantation - Development and study of a heart 

preservation chamber (dogs, sheep) 
P01HL18708-03 0010 Oxygen, energy and contractility in 

cardiac tissue • Tissue oxygen utilization (rats, dogs) 
ROlHL-187 10-02 Non-invasive reflection oximetry in 

peripheral tissue (dogs) 
ROIHL-1872503 Light-scattering studies of the sickling 

process (human) 
ROlHL-18808-04 0003 Prediction and prevention of 

sudden cardiac death - Technical support (computer) 
ROlHL-18947-02 Indirect mean arterial pressure 

(mammals) 
ROlHL-18968-03 

tomography 
ROlHL-18977-03 Non-invasive diagnosis of peripheral 

arterial disease (human, dogs) 
ROlHL-19003-03 High precision densitometry of coronary 

angiograms 
ROlHL-19019-03 

flow monitoring 
ROlHL-19038-02 Plethysmographic evaluation of carotid 

blood flow (human, rabbits, dogs) 
ROlHL-19065-02 Molecular oxygen in biological fluids 
Rapid specific micro measurement of 



Computer technology for transaxial 



Accurate transcutaneous Doppler blood 



Laser spectroscopy of lipoproteins 
Measurement of airways mechanics 
Heterogeneity of regional myocardial 



ROlHL-1908302 

blood cholesterol 
ROlHL-19095-03 
(human) 
" ROIHL-19118-03 
(human, dog) 
ROlHL-19135-04 
blood flow (dogs) 
** P50HL-19153-02 0008 SCOR-Pulmonary edemas-Eitology. 
pathogenesis ■ Core-Biomedical engineering 
P50HL-19170-02 0008 Harvard pulmonary SCOR -Chronic 

diseases of the airways - Multiple-transient artificial 
coughing (dogs, human) 
P50HL-19170-02 0010 Harvard pulmonary SCOR -Chronic 

diseases of the airways - Computer Core 
** P50HL-I9I87-02 0009 Pediatric pulmonary SCOR-Hyaline 

membrane disease - Non-invasive measurement and 
monitoring of arterial oxygen tension (dogs, sheep) 
** P50HL-19190-02 0009 Pulmonary SCOR-Pathophysiology, 

management of IRDS - Developing non-invasive neonatal 
pulmonary monitoring systems (rabbit, human) 
ROlHL-19275-03 Characterization of collateral blood 
vessels (dogs) 
** R01HL-I9352-03 Respiratory heat and water loss in 

neonates 
•* P50HL-19362-02 0011 A/S SCOR -Atherosclerosis in 

nonhuman primates - Chronic hypertension induced by 
operant conditioning techniques (baboon) 
" ROlHL-19414-03 Protection of myocardium during cardiac 

surgery (dogs, cats, human) 
M R01HL19451-03 Functional characteristics of the left 
heart 
ROlHL-19451-03 0001 Functional characteristics of the 

left heart - Ventricular performance using epicardial 
radiopaque markers (human) 
ROlHL-19451-03 0004 Functional characteristics of the 
left heart - Quantitative coronary arteriography (human) 
** ROlHL-19647-03 Therapeutic aerosols 

R01HL1970403 Aerosol therapy (models, dogs, human) 
** POlHL-19717-02 0046 Response of the lung to injury • 

Bioengineering section 
** R01HL19768-02 Recording and analysis of low levels 
cardiac signals (human, dogs) 



Gated imaging with the MGH x-ray 
Bolus-response measurement of lung 



Tissue analysis by mass spectrometer 
Catheter ventricular defibrillation studies 



Preservation of human platelets for 
Intra-aortic balloon pumping (dogs. 



36 

• R01HL1979102 Ultrasonic monitoring visceral blood 

vessels 
' R01HL1997301 Non-Invasive sickled cell monitor 

development (human) 
' ROlHL-19975-02 Laryngeal biomechanics in pulmonary 

therapy (primates) 
' ROlHL-19993-02 Optical detection of platelet aggregates 

(human, baboons) 
ROlHL-20024-03 Therapeutic aerosols -Characteristics and 

retention (human, dogs) 
' ROlHL-20037-02 Left ventricular-aortic bypass and 

composite prosthesis (sheep, swine, cattle) 
' ROlHL-20077-02 External cardiac stimulation with 

microwave radiation (dogs) 
ROlHL-201 10-02 Microwave methods of lung water 

measurement (dogs, phantom models) 

• ROlHL-2019202 Ciliary activity of the lung studied by 

laser scattering 
ROlHL-2027402 
camera 

• ROlHL-20347-02 

function (human) 

• ROlHL-20351-02 A self-calibrating in vivo blood gas 

monitor (dogs, infants) 
' ROlHL-20356 02 Development and evaluation of an 

artificial heart (calves) 
ROlHL-2037403 Myocardial function -Risk (actors and 

future CHD (human) 
ROlHL-2054602 Chemical analysis of human arterial 

elastin 
ROlHL-20554-02 Memory-alloy-filters for venous emboli 

(dogs) 
POlHL-20592-02 0012 Cell biology of cardiac and 

skeletal muscle - Contractile properties of skinned muscle 

fibers (frogs) 
ROlHL-20607-02 

(dogs) 

■ ROlHL-2062902 

(dogs) 
' ROlHL-2063003 Development of a pulsed Doppler velocity 

detector (human, animals) 
' ROlHL-20632-02 An optimal fetal heart monitor (human) 
ROlHL-2067402 Evaluation of cardiac function with 

radioactive tracers 
ROlHL-207 16-02 Freezing and electromagnetic thawing of 
platelets (rats) 

■ ROlHL-20788-02 

transfusion 
' ROlHL-20803-02 

lambs, cats) 
ROlHL-20815-02 Validation of indirect tests of small 

airways function (human, dogs, ponies) 
' ROlHL-2083502 Signal analysis of turbulence study in 

blood 
ROlHL-20898-02 Ultrasonic evaluation in direct arterial 

surgery (models, cattle, human) 
ROlHL-20979-02 A novel pulsed Doppler flowmeter (dogs) 
R23HL-21 168-01 Hypoxemic respiratory failure-Physiologic 

evaluation (human, dogs) 
R01HL-2I194-02 Development of antithrombogenic plastic 

biomaterials 
R23HL-2 11 99-02 Sound transmission in lung (dog) 
R23HL-21271-02 Extracorporeal circulation and protein 

denaturation (human) 
ROlHL-21278-01 Abnormal cardiac wall motion viewed 

ultrasonically (human, dogs, phantoms) 
ROlHL-21444-02 Pulmonary mechanics during postnatal 

development (human) 
ROlHL-21674-01 Development of automatic implanted 

defibrillator (dogs, cattle) 
R01HL-21707-0I Quantification of infarct size by emission 

tomography (human, dogs) 
ROlHL-21751-02 0003 ThaHium and antimyosin in 

ischemia and infarction ■ Human studies-Ischemia and 

infarction 
ROlHL-22005-01 Intermittent retroperfusion of ischemic 

myocardium (dogs) 
ROlHL-22032-01 Cardiovascular events in hypertensives 

(human) 
ROlHL-2208001 Phosphorus NMR studies on cardiac 

tissue (rats, rabbits) 
ROlHL-2228101 Microprobe analysis and metabolite 

levels of ischemic mycardium (dogs) 
ROlHL-223 15-01 Intraoperative cardiac oxygen supply- 
demand (dogs, rabbits, rats) 
ROlHL-22321-01 Cardiac output from the 

pneumocardiogram (dogs) 
ROlHL-22326-01 Noninvasive measurement of cardiac 

output (dogs) 
ROlHL-22338-01 Platelet adhesion and aggregation in a 

flow chamber (human) 
R23HL-2234601 Hematological injury and pulmonary 

dysfunction (human, mammals) 
ROlHL-22417-01 Microprocessors in medical applications 

(dogs) 
ROlHL-2251201 Ultrasonic instrumentation for 

cardiovascular studies 
ROIHL 22517-01 Engineering development of an ultrasonic 

ventilometer (human) 
R01HL-2260401 Non-invasive system for arteriosclerosis 

studies (human) 



BIO 

ROlHL-22636-01 Newborn lung function during 

mechanical ventilation (human) 
ROlHL-22661-01 Chronic total cardiopulhonary mechanical 

substitution (sheep) 
ROlHL-22699-01 Defibrillation electrode studies (dogs, 

swine) 
ROlHL-22809-01 Coronary-prone behavior and 

cardiovascular reactivity (human) 
ROlHL-2284401 Phrenic nerve pacing-Noninvasive 

diaphragm analysis (human, dogs) 
ROlHL-22854-01 Non-invasive blood pressure 

measurement (rats) 
ROlHL-22888-01 Prosthetic valve endocarditis-Etiology 

and therapy (dogs) 
P60HL-23282-01 0001 Comprehensive hospital/community 

sickle cell center • Fetoscopy for intrauterine diagnosis of 

hemoglobinopathy (human, monkeys) 
ROlHL-23983-01 Quantitative radiocardiography (human. 

dogs) 
NOlHR-32900-09 Pilot study to standardize the 

measurement of 'closing volume' (human) 
NOlHR-6290104 Measure pulmonary function in infants 

and children (also dogs, rabbits) 
NOlHR-62920-02 Noninvasive diagnosis of pulmonary 

hypertension (dog, human) 
N01HV12065-16 Fabrication of implantable artificial heart 

devices (animals) 
NOlHV-42914-13 Solenoid left ventricular assist system 

(cattle) 
NOlHV-42960-07 Development and evaluation of cardiac 

prostheses (calves) 
NOlHV-52966-01 Development and evaluation of an 

ultrasonic imaging system (swine) 
NOlHV-53008-07 Left ventricular assist device-Clinical 

evaluation (human) 
NOlHV-72918-01 

devices 
N01HV-72919-01 



Test polymers for circulatory assist 
Test polymers for circulatory assist 



Left heart assist blood pumps (calves) 
Development of a left heart assist blood 



'Excludes routine methodology OR covers only general projects which preclude indexing at the specific level. 
•*Onented significantly to above subject. 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigator's name and grant number 



divices 
NOlHV-7292404 Noninvasive detection of atherosclerotic 

lesions (human, animals) 
NOlHV-72925-04 Non-invasive detection of atherosclerotic 

lesions (human, monkeys, dogs) 
•* NOlHV-7292604 Ultrasonic imaging development 
** NOlHV-72927-00 Systems for non-invasive detection of 

atherosclerotic lesions (human) 
** NOlHV-72928-04 Develop high resolution ultrasonic 

imaging techniques 
NOlHV-72929-01 Improved detection of atherosclerosis 

(human, dogs) 
NOlHV-72930-02 Atherosclerosis assessment-Angiography 

and ultrasound (dogs, human) 
NOlHV-72931-02 Non-invasive detection of atherosclerotic 

lesions (human, dogs) 
NOlHV-7293200 Noninvasive detection of atherosclerotic 

lesions (human, phantoms) 
** NOlHV-72933-01 Electrical energy transmission technique 

development (dogs) 
" NOlHV-7293401 Development of a left heart assist blood 

pumps (human, cattle) 
** NOlHV-72936-00 Left heart assist device development 

(human, cattle) 
** NOlHV-72937-00 
** NOlHV-72938-01 

pump 
" NOlHV-72939-01 Develop and evaluate left heart assist 

blood pumps (human, calves, pigs) 
** NOlHV-72971-01 Energy converters to control heart assist 

devices (human, cattle) 
" NOlHV-72975-02 Energy converter for left ventrical assist 

devices (calves) 
** NOlHV-72976-02 Energy converters to control heart assist 

devices (human, cattle) 
NOlHV-81388-20 Microfiber substrate for growth of intimal 

linings in circulatory assist devices 
** NOlHV-82919-00 Development of percutaneous energy 

transmission systems 

BIOMEDICAL ENGINEERING, INSTRUMENTATION 
NOT CLINICALLY ORIENTED 

ROlHL-01015-27 Hypertension and left ventricular 

hypertrophy (dogs) 
ROlHL-02493-22 Kidney function in experimental heart 

failure (dogs, rats) 
POlHL-06285-18 0198 Cardiovascular-respiratory 

physiology and biochemistry - Renal tubular secretion of 

hydrogen ion (animals) 
POlHL-06296-18 0002 Cardiovascular and pulmonary 

adaptation to stress - Respiratory muscle blood flow. 

mechanics and metabolism (human, dog) 
POlHL-06314-17 0050 Immunologic mechanisms in 

cardiovascular disease - Physiologic changes in 

lymphocytes (human, mice) 
POlHL-07896-15 0045 Environmental biomedical research 

program - Extravascular lung water dynamics in pulmonary 

oxygen toxicity (human, baboons) 
** POlHL-08214-15 0006 Chemical and biological properties 

of lipids - Analysis and properties of lipids 
POlHL-08214-15 0040 Chemical and biological properties 

of lipids - Nuclear magnetic resonance studies of lipids 
** P01HL08214-15 0047 Chemical and biological properties 

of lipids ■ High resolution liquid chromatography for the 

analysis of biological substances 

(contd) 



^£S 



BIO 

•* POIHI 08805 15 0043 Rtgulslion ot venlilstioii »nd 
pulmonsry citciilation Compulef core tjcility 
ROIHI 089/; 14 Quanlitatioii o( flow and solute tlui in 

miciovessels (cats, lats) 
POIHI 09011 15 00?? A lesearch and resource program 
in blood Cryopreservation ol blood components (human) 
ROIHI 10330 11 Physiological mechanics ol the heart and 

arteries (dogs, rabbits, horses) 
ROIHI 11153 1? Quantitation ol How and solute llu> in 

microvessels (cats, rats) 
POIHI 11307 1? 000? Biophysical studies in pediatric 
cardiology Cardiac eitracellulai electiophysioiogy (human. 
dog, chimpaniee) 
POIHL 11351 12 0018 Cellular and molecular 
mechanisms ol myocardial function Quantitative 
localization of electrolytes in cardiac tissue 
POIHL 11351 1? 0019 Cellular and molecular 
mechanisms ot myocardial function Mechano chemical 
kinetics ol small perturbations 
"* POIHL 11678 11 9003 Cardiovascular dynamics and their 

control Core Instrumentation and machine shop 
•' ROIHL 11822 10 Biophysical studies of macromolecular 
interactions (microorganism, human) 
ROIHL 1252810 NMR relaxation of liquid crystal systems 
ROIHI 13399 16 Heme protein structure and function 

(human, horse, plants, bacteria) 
PO1HL1373707 0037 Assisted circulation Clinical 
measurement of blood flow through aortocoronary vein 
bypass graft 
P50HL 14147-08 0015 Specialized center of research in 
thrombosis ■ Charge related properties ot phospholipid 
surfaces in monolayers and vesicles 
P50HL15092-07 0001 Immune and fibrotic response to 
occupational environments ■ X-ray diffraction study-Dust 
exposure in asbestos cement products manufacturing 
P50HL-15092-07 0010 Immune and fibrotic response to 
occupational environments - Characterization of toluene 
diisocyanate in industrial environments 
POlHL-15194-07 9003 Pathophysiology of 

cardiopulmonary dysfunction ■ Electronics laboratory core 
ROlHL-15740-06 In vitro studies on heart cell function 

(rats) 
P60HL1600806 0017 Wayne State University 
comprehensive sickle cell center - Oxygen transport kinetics 
of pre- and post-sickling cells (human) 
POlHL-16607-05 0006 Calcium ion and control of 
cardiovascular function Sarcomere and contractile 
dynamics of striated muscle cells (animals) 
ROlHL-16828-04 Gradient and transport of oxygen in 

tissue and organs (mammals) 
POlHL-16833-04 0003 Hemoglobin and red cell system in 
hemoglobinopathies - Oxygen binding curves and equilibria 
(human) 
POlHL-16833-04 0008 Hemoglobin and red cell system in 
hemoglobinopathies - Membrane associated phenomena in 
SS disease 
POlHL-16833-04 0015 Hemoglobin and red cell system in 
hemoglobinopathies - Stereochemistry of hemoglobins from 
magnetic circular dichroism (human) 
R01HL-16855-03 Cavitation in biological systems 
(microorganisms, animals) 
** P60HL-17269-04 0016 National heart and blood vessel 
research and demonstration center - New analytical 
methodology for atherosclerosis studies 
•* POlHL-18208-04 00C2 Center for the study of blood cell 
rheology - Holography of RBC shape (human) 
P01HL-18574-C3 0001 Lipoprotein methodology and 
biomedical applications - Ulfracentrifugal and 
electrophoretic lipoprotein methodology-Applications 
POlHL-18576-03 0010 Thrombosis research program 

project - Evaluation of non-thrombogenic materials (cattle) 
POlHL-18576-03 0015 Thrombosis research program 

project ■ Major equipment core 
R01HL-18676-C3 Myocardial sarcomere mechanics (rat) 
ROlHL-18831-03 Microscopy of spontaneously hypertensive 

arterial lesion (rats) 
R01HL18952-03 Metabolism in. perfused fetal and 

newborn rabbit lungs 
POlHL-19259-03 0006 Digoxin-specific antibody in human 
therapy - Core 
** ROlHL-19481-03 High-field NMR studies of respiratory 
proteins (human, horse, fish, microbes) 
ROlHL-19715-02 Respiratory tract deposition of 

hygroscopic aerosols (dogs, human) 
POlHL-19737-02 0012 Cellular and molecular aspects of 
respiratory physiology - Mass spectrometer facility 
** ROlHL-19848-02 Contractile activation by rapid 

temperature jumps (frogs) 
** ROlHL-20354-02 Direct determination of oxygen tension in 

the clinical environment (human, dogs) 
♦* POlHL-20592-02 0003 Cell biology of cardiac and 

skeletal muscle - Cellular magnesium and anion activities 
in ion-specific microelectrodes (frogs) 
P01HL-210I6-02 CC18 Sickle cell anemia and other 
hemoglobinopathies - Scanning and transmission electron 
microscopy 
ROlHL-21371-02 Energy loss microanalysis of myocardial 
cations 
** P01HL-22163-CI 0002 Surface thrombogenesis- 

Mechanisms and prevention - Laser-scattering detection of 
microemboli in blood flow (baboons) 



37 

ROIHI 77??3 01 The cardio pulmonary lunction (do|>. 

niudelsl 
** ROIHI ???33 01 Characterizntmn ol bio materials by 

elastic property 
ROIHI ??3?5 01 Thermodynamics in respiratory protein 

binding (human trout) 
ROIHI ??91/ 01 Miciovasculai picssures in the intact 

beating heart (rabbits) 
R?3Hl ??9?0 01 Dynamic airway behavior (dogs) 
ROIHI ?3?G7 01 Rheology and kinetics of hemoglobin S 

Relation (human) 

BIOMEDICAL ENGINEERING, MEDICAL 
EQUIPMENT SAFETY 

ROIHL 0466b 19 Artificially paced hearts- Technology, 
physiology (human, dogs) 
** ROIHL 15247 05 Extending the life of implanted 
pacemakers (dogs, human) 
P60HL 17269 04 0030 National heart and blood vessel 
research and demonstration center Cardiovascular 
engineering laboratories (human) 
** ROIHL 1997502 Laryngeal biomechanics in pulmonary 
therapy (primates) 
ROIHL 2007702 External cardiac stimulation with 
microwave radiation (dogs) 
** ROIHL 20803 02 Intra aortic balloon pumping (dogs. 

lambs, cats) 
** ROIHL 22699 01 Defibrillation electrode studies (dogs, 
swine) 
NOIHV 42914 13 Solenoid left ventricular assist system 
(cattle) 

BIOMEDICAL FACILITIES 

SEE ALSO ANIMAL FACILITIES, RESOURCES 
SEE ALSO BIOMEDICAL SYSTEMS AUTOMATED 
SEE ALSO HEALTH CARE FACILITIES (GENERAL) 
POIHL 04664 18 0005 Cardiovascular and lung dynamics 
Applications of current research, equipment and 
techniques 
POIHL 04664-18 0011 Cardiovascular and lung dynamics 
- Detection of abnormal segments of the human ventricle 
by measure of asynergy 
POlHL-04664-18 0015 Cardiovascular and lung dynamics 

■ Computer system for the cardiovascular laboratory 
P01HL06350-I7 0018 Hemostasis research program 
project - Varients of factors IX (human, cattle) 
** POlHL-06664-17 0041 Cardiopulmonary function in 

remediable vascular disease - Core facility for quantitative 
microscopy 
P01HL08805-15 0042 Regulation of ventilation and 
pulmonary circulation - Electron microscope core research 
laboratory 
POlHL-08805-15 0043 Regulation of ventilation and 
pulmonary circulation - Computer core facility 
** POlHL-08974-14 9001 Natural and experimental 

atherosclerosis - Core-Lipid chemistry laboratory 
** POIHL-08974-14 9002 Natural and experimental 
atherosclerosis - Core-Histology and histochemistry 
laboratory 
** POlHL-10342-13 9001 The integrated function of 

respiration and circulation ■ Technical core 
** PClHL-11307 12 9001 Biophysical studies in pediatric 

caidiology - Core support-computer science 
** POlHL-1 1307-12 9002 Biophysical studies in pediatric 

cardiology - Biomedical engineering 
** POlHL-11310-12 9001 Mechanisms of cardiovascular 

disease - Core support-hospital beds 
** POlHL-11310-12 9002 Mechanisms of cardiovascular 
disease - Core support-centralized electronic laboratory 
** POlHL-11310-12 9003 Mechanisms of cardiovascular 

disease - Core support-biophysical sciences 
** POlHL-11310-12 9004 Mechanisms of cardiovascular 

disease - Core support-computer facilities 
** POlHL-11678-11 9001 Cardiovascular dynamics and their 

control - Core-Computer services 
** POlHL-1 1678-11 9002 Cardiovascular dynamics and their 

control - Core-Radioimmunoassay and chemical laboratory 
** POlHL-11678-11 9003 Cardiovascular dynamics and their 

control ■ Core -Instrumentation and machine shop 
** POlHL-12373-10 0014 Cardiopulmonary physiology and 
pathophysiology - Analog digital computation and 
simulation facility 
POlHL-12373-10 0015 Cardiopulmonary physiology and 
pathophysiology - Cine angiographic-hemodynamic facility 
POIHL-12373-10 0016 Cardiopulmonary physiology and 
pathophysiology - Histology-histochemistry-Gough laboratory 
** POlHL-12373-10 0018 Cardiopulmonary physiology and 
pathophysiology Biochemistry laboratory 
POlHL-12373-10 0019 Cardiopulmonary physiology and 
pathophysiology - Free ranging animal facility 
** POIHL 12373-10 0020 Cardiopulmonary physiology and 
pathophysiology - Hospitalization and patient care 
POlHL-13330-08 0062 Mechanical circulatory support - 

CORE facilities 
ROlHL-13881-08 The American Red Cross National 
Fractionation Center 
*' ROlHL-13885-08 9001 Cystic fibrosis and pulmonary 
disease - Pulmonary function core facility (infants, 
children) 
** ROlHL-13885-08 9002 Cystic fibrosis and pulmonary 
disease - Computer core facility (human) 



•Excludes routine methodology OR covers only general projects which preclude indexing at the specific level 
"•Oriented significantly to above subject 



M Grant has subprojects describing specific 
See AppendiK for investigator's name and gr 



BIO 

•• ROIHI 13885 08 9003 Cystic librov. and pulmonary 
diKise Fiberoptic bronchoscopy core licilrly (human, 
dogs, sheep) 
ROIHI 13974 0/ Vtnlriculir premitur* txalt and luddtn 

coronary death (human) 
P50HI 14136 07 900? Pulmonary SCOR Airway, 
obstructive diseases Physiology core (human animal) 
*• P50HI 14136 07 9003 Pulmonary SCOR Airway, 
obstructive diseases Pathology core (human, dogs) 
P50HI 14136 07 9004 Pulmonary SCOR Airway, 
obstructive dr.eases Radiology core (human) 
*• P50HI 141160/ 9007 Pulmonary SCOR Airway, 

obstructive diseases Special Isi.ililie', core 
P50HI 14138 05 0014 Center lor re'.earch on 

atherosclerosis Core biostatislic, laboratory 
** P50HI I4I47 08 0016 Specialized center of research in 
thrombosis Nuclear medicine core laboratory (human, 
dogs, rats, rabbits) 
•* PbOni 14147 08 0017 Specialized center ol research in 

thrombosis Core coagulation laboratory (human) 
** P50HL 14153 07 0018 lohns Hopkins lung Center 

Chronic diseases of airways Pulmonary function core 
** P50HI 14153 07 0019 lohns Hopkins lung Center 
Chronic diseases of airways Pathology core (human, 
animal) 
** P50HL 14159 08 0022 Specialized center of research in 

hypertension Core laboratory 
** P50HL 14159 08 0023 Specialized center of research in 

hypertension Core computation 
** P50HL 14159 08 0024 Specialized center of research in 

hypertension Core resources (clinical, animal models) 
•• P50HL 14164 07 0026 A/S SCOR Comparative and 

experimental atherosclerosis Comparative pathology unit 
(pigeons, monkeys) 
** P50HL 14164 07 0034 A/S SCOR Comparative and 

experimental atherosclerosis Core lipid analytic laboratory 
** P50HL 14164-07 0039 A/S SCOR -Comparative and 
experimental atherosclerosis Statistical resource and 
research management unit 
** P50HL-14164-07 0040 A/S SCOR Comparative and 
experimental atherosclerosis Core angiochemistry 
laboratory 
** P50HL 14164-07 0042 A/S SCOR -Comparative and 
experimental atherosclerosis Comparative cardiology 
laboratory (monkeys) 
" P50HL 14164-07 0043 A/S SCOR -Comparative and 

experimental atherosclerosis - Electron microscopy resource 
laboratory 
** P50HL-14187-07 0016 Pulmonary SCOR -Chemical 
mediators in pulmonary vascular responses - Core 
pathology service (dogs, rabbits, human) 
" P50HL-14197-07 0008 Support for center of research on 
arteriosclerosis - Core facility -Lipoprotein preparation, 
immunochemistry 
** P50HL-14214 07 0037 Newborn lung center for hyaline 

membrane disease - Core -Histopafhology laboratories 
** P50HL-14217-08 0063 Specialized center of research in 

thrombosis - Special clinical studies laboratory 
** P50HL 14230 07 9001 A/S SCOR Lipids, atherosclerosis 

and thrombosis Core lipid laboratory 
*♦ P50HL-14230-07 9002 A/S SCOR -Lipids, atherosclerosis 

and thrombosis - Core tissue culture laboratory 
** P50HL-14237-07 0007 Support for arteriosclerosis center 

- Core laboratories 
M POlHL-1438807 Regulation of the circulation in 

pathological states 
** POlHL-1438807 9001 Regulation of the circulation in 

pathological states - Core facility for hypertensive animal 
colony (rats) 
** POIHL 14388-07 9002 Regulation of the circulation in 

pathological states - Core immunoassay laboratory (rabbits) 
** POlHL-14388-07 9003 Regulation of the circulation in 

pathological states - Electron probe projects 
" POlHL-14388-07 9004 Regulation of the circulation in 

pathological states - Core biostatistics unit 
** POlHL-14388 07 9005 Regulation of the circulation in 

pathological states - Core administration 
** POlHL-14414-07 9001 Environmental influences on 
cardiorespiratory and cellular functions ■ Laboratory core 
facility 
** POlHL-14414-07 9002 Environmental influences on 
cardiorespiratory and cellular functions - Core -Computer 
facility 
** POlHL-14414-07 9003 Environmental influences on 
cardiorespiratory and cellular functions - Machine and 
electronics shop -Core facility 
" P50HL-15O62-07 0021 Study of lipoproteins, artery wall. 

and atherosclerosis - Core laboratories 
** P50HL-15092-07 0013 Immune and fibrotic response to 

occupational environments - Epidemiology core resource 
** P50HL-15092 07 0014 Immune and fibrotic response to 
occupational environments Clinical immunology core 
resource 
P60HL-15158-07 00C4 Comprehensive sickle cell center ■ 
Expression of abnormal hemoglobin synthesis in the 
neonate and young child 
** P60HL-15160-07 0012 Center for sickle cell disease - 

Core laboratories 
" POlHL-15194-07 9001 Pathophysiology of 

cardiopulmonary dysfunction - Analytical laboratory core 

(contd) 
research aspects, 
ant number 



P01HL16851-04 0010 
health and disease - 

P01HL16851-04 0011 
health and disease - 

P0IHL16851-04 0012 
health and disease - 

P01HL16878-05 0005 



BIO 

POlHL-15194-07 9002 Pathophysiology of 
cardiopulmonary dysfunction - Data piocessing laboratory 
core 
** P01HL15194-07 9003 Pathophysiology of 

cardiopulmonary dysfunction - Electronics laboratory core 
POlHL-15265-05 0004 Program on surgical control of the 
hyperlipidemias • Coordinating center and central data 
processing facility 
** P50HL-15389-07 0016 Pulmonary SCOR-Hypersensitivity 

pneumonitis - Pulmonary physiology core (human) 
** P50HL1538907 0017 Pulmonary SCOR-Hypersensitivity 

pneumonitis - Immunology core (human) 
** P50HL15389-07 0018 Pulmonary SCOR-Hypersensitivity 

pneumonitis - Pathology core (human, animal) 
** P50HL-15389-07 0019 Pulmonary SCOR-Hypersensitivity 

pneumonitis - Microbiology core (human, animal) 
** P01HL.1583206 9001 Chemical-structural predispositions 
to lung injury Tissue culture studies of lung cell function- 
Core facility 
** POlHL-1583506 0027 Study of muscles related to heart 

disease - Core ll-lntermediate voltage EM of muscle 
** P6OHL-160O5-O5 9001 Comprehensive sickle cell center - 

Core laboratory and counseling (human) 
*• POlHL-16769-05 0009 Pathobiologic and host defense 
reactions in the lung - Electron microscopy and tissue 
culture core laboratory 
POlHl-16769-05 0011 Pathobiologic and host defense 
reactions in the lung ■ Core -Laboratory for biomedical 
preparation (rabbits) 
M POlHL-16851-04 Human red cell membrane in health and 
disease 

Human red cell membrane in 
Core facility -Hematology clinic 

Human red cell membrane in 
Ultrastructure laboratory-Core facility 

Human red cell membrane in 
Computer unit-Core facility 
Control of ventilation in health 
and disease - Program core 
P60HL- 17269-04 0004 National heart and blood vessel 
research and demonstration center - Atherosclerosis - 
Clinical surgical aspects (human) 
P60HL-17269-04 0027 National heart and blood vessel 
research and demonstration center - Non-invasive 
evaluation of cardiac functlon-lschemic heart disease 
(human, dog) 
** POIHL- 1742 1-05 0006 Regulation and exchange in the 
microcirculation - Core facilities -Optical instrumentation 
facility 
** P50HL-1 7646-04 0001 Study of ischemic heart disease - 

Core clinical investigation unit 
** P50HL- 17646-04 0002 Study of ischemic heart disease - 

Core data management 
** P50HL-1 7646-04 0003 Study of ischemic heart disease - 

Core pathology facility (human, dogs) 
** P50HL-17646-04 0004 Study of ischemic heart disease - 

Core experimental animal laboratories 
** P50HL-17648-04 0020 Study of ischemic heart disease - 
Core pathology laboratory-lschemic heart disease (human, 
animal) 
M P50HL-17651-04 Ischemic heart disease specialized center 
of research 
P50HL-1 7651-04 0032 Ischemic heart disease specialized 
center of research - Cardiovascular surgery core (human, 
dogs) 
** P50HL-17651-04 0033 

center of research 
" P50HL-17651-04 0035 
center of research 
biophysics 

** P50HL-17651-04 0036 Ischemic heart disease specialized 
center of research - Core facilities -Cardiovascular 
pathology (human, dog) 
P50HL-1 7651-04 0046 Ischemic heart disease specialized 
center of research - Clinical core-Physiological 
changes/biochemical effects of myocardial ischemia 
P50HL-17651-04 0047 Ischemic heart disease specialized 
center of research - Clinical core-Automated arrhythmia 
monitoring system 
** P50HL-1 7655-04 0010 Study of ischemic heart disease - 

Core facility -Cardiovascular pathology (human, animal) 
** P50HL-17655-04 0011 Study of ischemic heart disease - 
Core facility -Cardiovascular nuclear medicine (human, dog) 
** P50HL-17665-04 0008 Study of ischemic heart disease - 
Core laboratory-CPK isoenzyme measurement and 
myocardial necrosis evaluation 



Ischemic heart disease specialized 
Core facilities -Computer sciences 

Ischemic heart disease specialized 
Core facilities-Biomedical engineering, 



Study of ischemic heart disease 
Study of ischemic heart disease 



P50HL-1 7665-04 0030 

Data management 
P50HL-1 7667-04 0038 

Clinical core unit 
P50HL-17667-04 0039 Study of ischemic heart disease - 

Core human investigative laboratories 
P50HL-1 7667-04 0040 Study of ischemic heart disease - 

Core biochemistry-Cardiac metabolism (human) 
P50HL 17667-04 0041 Study of ischemic heart disease - 

Biophysical sciences core-Data collection and retrieval 
P50HL-1 7667-04 0042 Study of ischemic heart disease - 

Core-Central instrumentation and software 
P50HL-1 7667-04 0044 Study of ischemic heart disease - 

Core-Data management and analysis 
P50HL- 17670-04 0016 Study of ischemic heart disease - 

Core pathology laboratory (human, dogs, monkeys) 



Study of ischemic heart disease 
Study of ischemic heart disease 



38 

P50HL-17670-04 0017 Study of ischemic heart disease 

Core enzymology laboratory (human) 
P50HL-17670-04 0018 Study of ischemic heart disease ■ 

Core electrocardiogram laboratory (human) 
P50HL- 17682-04 0008 

Clinical core unit 
P50HL-17682-04 0009 

Computer core unit 
P50HL- 17682-04 0010 Study of ischemic heart disease - 

Core clinical enzyme laboratory (human, mice, dogs, rats) 
P50HL-17682-04 0011 Study of ischemic heart disease - 

Nuclear medicine core unit (human, dogs, rabbits, mice) 
P50HL-17682-04 0012 Study of ischemic heart disease - 

Pathology core laboratory (human) 
P50HL-1 7682-04 0023 Study of ischemic heart disease - 

Core cell and organ culture laboratory (mice) 
P50HL-183 18-03 0001 Pathogenesis and complications of 

hypertension - Core clinical program 
P50HL-18318-03 0002 Pathogenesis and complications of 

hypertension - Core experimental animal facility (rats. 

rabbits) 
P50HL-18318-03 0003 Pathogenesis and complications of 

hypertension - Core biochemical laboratory 
P50HL-18323-04 0033 SCOR hypertension center - Core 

laboratory-Renin, aldosterone and bradykinin methodology 
P50HL 18323-04 0034 SCOR hypertension center - Core- 
Data management 
POlHL-18575-03 0011 Mechanisms of vascular changes 

in hypertension - Chemistry laboratory core facility 
POlHL-18575-03 0012 Mechanisms of vascular changes 

in hypertension - Anatomy core facility 
POlHL-18575-03 0013 Mechanisms of vascular changes 

in hypertension - Biosfatistical core 
POlHl-18576-03 0014 Thrombosis research program 

project - Immunology core 
POlHL-18576-03 0015 Thrombosis research program 

project - Major equipment core 
POlHL-18576-03 0016 Thrombosis research program 

project - Radiochemistry core 
POlHL-18577-03 0008 Lipoproteins-Cell surface 

interactions - Core laboratory 1 
POIHL 18577-03 0011 Lipoproteins-Cell surface 

interactions Core laboratory 4 
POlHL-18708-03 0008 Oxygen, energy and contractility in 

cardiac tissue - Cardiac cell culture facility 
POIHL- 189 74-03 0014 Experimental neurogenic 

hypertension program - Administrative core 

Experimental neurogenic 
Neurochemistry core 
Experimental neurogenic 
Neuroanatomy core 
Experimental neurogenic 
Computer-physiology core 
SCOR-Pulmonary edemas-Eitology, 



* POlHL-18974-03 0015 

hypertension program 
' POlHL-18974-03 0016 

hypertension program 
' POlHL-18974-03 0017 

hypertension program 

• P50HL-191 53-02 0007 

pathogenesis - Core-Experimental laboratories and support 
facilities 
' P50HL-191 53-02 0008 SCOR-Pulmonaiy edemas-Eitology, 

pathogenesis - Core -Biomedical engineering 
' P50HL-191 55-02 0008 Pathophysiology of pulmonary 

edema - Core microscopy laboratory 
' P50HL-19156-02 0006 Pulmonary SCOR -Chronic diseases 

of airways - Core microscopy laboratory 
■ P50HL-191 57-02 0001 Studies in cystic fibrosis and 

bronchiolitis - Laboratory core unit 
' P50HL-19157-02 0002 Studies in cystic fibrosis and 

bronchiolitis - Clinical core 
' P50HL-191 70-02 0010 Harvard pulmonary SCOR -Chronic 

diseases of the airways - Computer Core 
' P50HL-191 71-02 0012 Pulmonary SCOR -Lung injury by 

childhood infections - Laboratory support core 
' P50HL-191 85-02 0012 Pulmonary SCOR -Neonatal 
respiratory distress syndromes - Core microscopy lab 
P50HL-19187-02 0013 Pediatric pulmonary SCOR-Hyaline 

membrane disease - Research resources core 
P50HL-191 90-02 0001 Pulmonary SCOR -Pathophysiology, 
management of IRDS - Core-Clinical research center 
(infants) 
P50HL-19 190-02 0002 
management of IRDS 
dissemination 
POIHL- 192 59-03 0006 

therapy - Core 
P50HL-19362-02 0013 A/SSCOR-Atherosclerosis in 
nonhuman primates - Core laboratory-Lipid biochemistry 
(baboons) 
P50HL-19362-02 0014 A/S SCOR -Atherosclerosis in 
nonhuman primates - Core laboratory-Behavior observation 
and manipulation (baboon) 
P50HL-19362-02 0015 A/S SCOR -Atherosclerosis in 
nonhuman primates - Core laboratory-Pathology and 
morphometry (baboons) 
P50HL- 193 62-02 0016 A/S SCOR -Atherosclerosis in 
nonhuman primates - Core laboratory-Animal services 



Pulmonary SCOR -Pathophysiology, 
Core-Demonstration and 

Digoxin-specific antibody in human 



(baboon) 
P50HL-19362-02 0017 

nonhuman primates - 

statistical analysis 
POlHL-19737-02 0012 

res|>iratory physiology 
POlHL-19737-02 0013 

respiratory physiology 



A/S SCOR -Atherosclerosis in 
Core laboratory -Data management. 

Cellular and molecular aspects of 

- Mass spectrometer facility 

Cellular and molecular aspects of 

- Cell metabolism analytical facility 



BIO 

POlHL-19737-02 0014 Cellular and molecular aspects of 

respiratory physiology - Cell separation facility 
POlHL-20552-02 9001 The development and regression of 

cardiac hypertrophy - Core A-Pathology 
POlHL-20552-02 9003 The development and regression of 

cardiac hypertrophy - Core D-Amino acids analysis 
POlHL-20581-01 9001 Vascular neuroeffector 

mechanisms in health and disease - Morphology core 
POlHL-20581 01 9002 Vascular neuroeffector 

mechanisms in health and disease - Biochemistry core 
POlHL-20592-02 0014 Cell biology of cardiac and 

skeletal muscle - Core laboratory 
POlHL-20948-02 9001 Molecular basis of cholesterol 

metabolism - Tissue culture core laboratory 
POIHL 20948-02 9002 Molecular basis of cholesterol 

metabolism - Microscopy core laboratory 
POlHL-20984-02 Cellular mechanisms in cardiac 

hypertrophy 
POlHL-20984-02 9001 Cellular mechanisms in cardiac 

hypertrophy - Animal models and preparation of contractile 

proteins 
POlHL-20984-02 9002 Cellular mechanisms in cardiac 

hypertrophy - The heart in organ culture 
POlHL-20993-02 0011 Population dynamics of arterial 

cells in atherogenesis - Light and electron microscopy 

laboratories-Core 
POlHL-20993-02 0012 Population dynamics of arterial 

cells in atherogenesis - Chemistry laboratory -Core 
POIHL-20994-02 Dynamics of neutrophil elastase in the 

lung 
POlHL-20994-02 9001 Dynamics of neutrophil elastase in 

the lung - Biochemistry and immunology core 
POlHL-20994-02 9002 Dynamics of neutrophil elastase in 

the lung - Ultrastructural core 
POIHL 20994-02 9003 Dynamics of neutrophil elastase in 

the lung - Autoradiography-Histology core 
POlHL-2 1016-02 0018 Sickle cell anemia and other 

hemoglobinopathies - Scanning and transmission electron 

microscopy 
POlHL-2 1584-02 9001 Respiratory mechanics in normal 

and abnormal states - Technical and equipment core 
ROlHL-2 1684-02 0003 Radionuclide infarct sizing and 

therapy evaluation - Core pathology laboratory (dogs, 

human) 
POlHL-22163-01 9001 Surface thrombogenesis- 

Mechanisms and prevention - Polymers for studing blood- 
material interactions core 
POlHL-22602-01 9001 Pathophysiology of the 

endothelium - Morphology core 
POlHL-22602-01 9002 Pathophysiology of the 

endothelium - Core -Culture of blood vessel-Derived cells 
POlHL-22619-01 9001 Cellular mechanisms of heart 

failure - Experimental pathological models core 
POlHL-22619-01 9002 Cellular mechanisms of heart 

fail 
POlHl-22619-01 9003 Cellular mechanisms of heart 

failure - Computer facility core 

P01HLt»J63MUj(Mi|lcheml6l#utofda(HhlW(eimtetM)lflgy of 

lipoprotein metabolism - Tissue culture core 
POlHL-22633-01 9002 Cellular and molecular biology of 

lipoprotein metabolism - Lipoprotein laboratory core 
P60HL-23282-01 Comprehensive hospital/community sickle 

cell center 
P60HL-23282-01 9001 Comprehensive hospital/community 

sickle cell center - Core-lnstitutionalization of education, 

screening and counseling 
P60HL-23282-01 9002 Comprehensive hospital/community 

sickle cell center - Core-Model sickle cell service for 

neighborhood health centers 
NOlHR-62930-03 Lung cell resource facility 

Modification of silicon elastomers for 



NOlHV-32949-11 
medical devices 

N01HV-72950-02 
trial 



Central laboratory for propranolol heart 



•Excludes routine methodology OR covers only general projects which preclude indexing at the specific level 
•*Oriented significantly to above subject- 



M Grant has subprojects describing specific research aspects. 
See Appendix for investieator's name and grant number 



BIOMEDICAL MANPOWER 

SEE HEALTH SCIENCES PROFESSIONS, HEALTH SCIENCES 
MANPOWER 

BIOMEDICAL REGISTRIES AND REFERRAL 
CENTERS 

SEE ALSO BLOOD PRESERVATION. BLOOD BANKS, CENTERS- 
RESOURCES-REGISTRIES 
SEE ALSO CHEMICAL AND DRUG REGISTRIES, REFERRAL 

CENTERS AND RESOURCES 
SEE ALSO GENETIC REGISTRIES AND REFERRAL CENTERS 
SEE ALSO HEALTH RECORD SYSTEMS, PATIENT (DISEASE) 

REGISTRIES 
SEE ALSO HEALTH SCIENCES PROFESSIONS, HEALTH 

SCIENCES MANPOWER DATA AND REGISTRIES 
SEE ALSO TISSUE (CELL) CULTURE, CELL CULTURE 
COLLECTIONS BANKS AND REGISTRIES 
SEE ALSO TISSUE COMPATIBILITY-TRANSPLANTATION 
RESOURCES, REFERRAL CENTERS AND 
REGISTRIES 
SEE ALSO TISSUE RESOURCES, REGISTRIES 
ROlHL-04651-19 Remote stimulation by radio-frequency 
transmission (dogs, human) 
M POlHL-04664-18 Cardiovascular and lung dynamics 
POlHL-08899-14 0072 Tolerance to respiratory gases in 
health and disease - Inert gas exchange isobaric gas 
counterdiffusion and decompression 

(csntd) 



■lO 

801HI 10&I2 12 Thrombojis ind htmostisis AntlYJii, 

mtthodi «nd ilindicdi (human, cattlt. venom) 
•* PSOHl 14164 07 0039 US SCOR Compilative ind 

aipeiimtntal atharoscltrasit Statiitical rasourct and 

lesaaich mana|«mant unit 
** P60HL 15158 07 0008 Compuhanjive sickle cell centei 

Con lalraiatory ol tlie centei 
P60HL 1726904 0004 National heart and blood vessel 

rtstaich and demonstiation centei Atheioscleiosis 

Clinical surgical aspects (human) 
P60HL 17292 04 0023 Veimont Lunt Centei Health 

inhumation lesouices 
POIHI 18575 03 0013 Mechanisms ol visculai changes 

in hypertension Biostatistical coie 
*• NOIHV 53010 03 NAS NRC twin tegistry 

BIOMEDICAL RESEARCH 

SFf HEALIH SCIENCFS RESEARCH (GENERAL)* 
BIOMEDICAL RESEARCH-EVAIUATION- 
PLANNING 

SEE HEALTH SCIENCES RESEARCH ANALYSIS EVALUATION 
PUNNING 
BIOMEDICAL RESOURCES (GENERAL) 

SEE ALSO ANIMAL FACILITIES, RESOURCES 

SEE ALSO BIOLOGICAL PREPARATIONS AND STANDARDIZATION 

SEE ALSO BLOOD PRESERVATION. BLOOD BANKS. CENTERS 

RESOURCES REGISTRIES 
SEE ALSO CHEMICAL AND DRUG REGISTRIES. REFERRAL 

CENTERS AND RESOURCES 
SEE ALSO IMMUNOLOGICAL PREPARATIONS 

(GENERAUdNCLUOING CERTIFICATION AND 
STANDARDIZATION) 
SEE ALSO TISSUE (CELL) CULTURE, CELL CULTURE 
COLLECTIONS BANKS AND REGISTRIES 
SEE ALSO TISSUE RESOURCES, REGISTRIES 
ROIHL 1088013 Purification ot human erythropoietin tor 

research use 
POIHL 13330 08 0062 Mechanical circulatoiv support 

CORE facilities 
ROIHL 13587 06 Synthesis of renin inhibitors and analog 

phosphatides (rats) 
P60HL15168-07 0001 Comprehensive sickle cell disease 

center - Screening program (human) 
R01HL1667505 Human urinary erythropoietin collection 
POlHL-18708-03 0008 Oxygen, energy and contractility in 
cardiac tissue - Cardiac cell culture facility 
•* P01HL19717-02 0046 Response of the lung to injury ■ 

Bioengineering section 
ROlHL-202 19-02 Cryopreservation of the isolated heart 
(rats) 
BIOMEDICAL SYSTEMS AUTOMATED 

SEE ALSO COMPUTER (GENERAL) INCL COMPUTER DATA 

PROCESSING (GENERAL) 
SEE ALSO COMPUTER CENTERS 
SEE ALSO HOSPITALS. INTENSIVE CARE UNITS 
SEE ALSO OPTICS. IMAGE PROCESSING ANALYSIS AND 

DISPLAY* 
POlHL-0466418 0008 Cardiovascular and lung dynamics 

■ Micrographic video imaging technique 
P01HL0821415 0047 Chemical and biological properties 
of lipids • High resolution liquid chromatography for the 
analysis of biological substances 
P01HL-0901M5 0017 A research and resource program 
in blood • Operations research laboratory 
** P01HL11310-12 0093 Mechanisms of cardiovascular 

disease - Multiple dipole electrocardiogram project (human, 
dogs) 
POlHL-12373-10 0014 Cardiopulmonary physiology and 

pathophysiology - Analog digital computation and 
simulation facility 
P50HL14138-05 0008 Center for research on 
atherosclerosis - Core lipid laboratory (human) 
P50HL1414105 0008 SCOR for atherosclerosis in 
childhood - Core laboratory 
*♦ P50HL-14236-05 0012 Prevention of premature 

arteriosclerosis ■ Automated lipid analysis 
** POlHL-15265-05 0003 Program on surgical control of the 

hyperlipidemias ■ Central lipid laboratory 
** P60HL-17269-04 0016 National heart and blood vessel 
research and demonstration centei - Nev» analytical 
methodology for atherosclerosis studies 
ROlHL-20546-02 Chemical analysis of human arterial 

elastin 
ROlHL-20751-01 High speed liquid chromatography of 

hemoglobins (human) 
ROlHL-20788-02 Preservation of human platelets for 
transfusion 
BIOMEDICAL SYSTEMS AUTOMATED, COMPUTER 

ASSISTED DIAGNOSIS 
M POlHL-0466418 Cardiovascular and lung dynamics 

P01HL-04664-18 0003 Cardiovascular and lung dynamics 

■ X-ray projection image videometry (human, dogs) 
POlHL-0466418 0005 Cardiovascular and lung dynamics 

- Applications of current research, equipment and 
techniques 

POlHL-04664-18 0009 Cardiovascular and lung dynamics 

- Biological signal and image processing techniques (dogs) 
•* POlHL-04664-18 0010 Cardiovascular and lung dynamics 

- Lett ventricular dynamics (human) 



39 

' POIHI 04664 18 0011 Caidiovasculai and lung dynamics 

Detection ol abnormal jegmanls ol the human ventricle 
by measure ot asyneigy 
' POlHt 04664 18 0012 Cardiovascular and lung dynamics 

Quantitative single plane lelt venlriculai angiogiaphy 
(human) 
' POIHI 04664 18 0013 Cardiovascular and lung dynamics 

Ventriculai (unction in coionaiy disease using NTC and 
ventiiculogiams (human) 
' P01H104664 18 0014 Caidiovasculai and lung dynamics 

Clinical application of computer analysis ol ventricular 
wall motion 
POIHL 04664 18 0015 Cardiovascular and lung dynamics 

Computei system lor the cardiovascular laboiatory 
POIHI 06308 18 0010 Mechanisms and therapy ol 

circulatory disease Ventricular arrhythmias during exercise 
to CHO and myocardial ischemia (human) 

• R01H107575 15 Analysis ot time coherent cardiovascular 

data 

* POIHL 11678 11 0058 Cardiovascular dynamics and their 

control Overall control of the circulation Computer 
analysis 
POIHL 12373 10 0014 Cardiopulmonary physiology and 

pathophysiology Analog digital computation and 
simulation facility 
ROIHL 1397407 Ventricular premature beats and sudden 

coronary death (human) 
ROIHL 15016 07 New concepts in cardiac ultrasound 
technology (human) 
*• ROIHL 1504706 Digital computer analysis of the 
electrocardiogram (human) 
ROIHL 15191 07 Multiparameter methods for 

cardiovascular research 
POIHL 15265 05 0012 Program on surgical control of the 

hyperlipidemias Central arteriography-Radiography 
laboratory (human) 
** R01HL16260-04 Development of clinical cine ultrasound 

cardiography 
•• ROlHL-16403 05 Prognostication by computer-Analyzed 
vectorcardiogram (human) 
ROlHL-16487-05 Computer controlled two dimensional 
echocardiography 
" ROlHL-1679103 Computer linkage for a dual camera 
system 
ROlHL-16901-05 Multipolar linkage between heart 

geometry and surface (human, dogs) 
ROlHL-16908-04 Myocardial function, risk factors and 

future CHD (men) 
ROlHL-16909-04 Myocardial function, risk factors and 
future CHD (men) 
** P60HL-17269-04 0026 National heart and blood vessel 
research and demonstration center - Dynamics of ischemic 
heart disease (human, dog) 
P60HL-17269-04 0027 National heart and blood vessel 
research and demonstration center - Non-invasive 
evaluation of cardiac function-lschemic heart disease 
(human, dog) 
P60HL-1 7292-04 0031 Vermont Lung Center - Regional 

respiratory computer network 
P50HL-17646-04 0002 Study of ischemic heart disease - 

Core data management 
P50HL-17646-04 0010 Study ot ischemic heart disease - 
Compliance in ischemic myocardium-Altered cardiac 
performance (human, dogs) 
** P50HL-17648-04 0006 Study of ischemic heart disease ■ 
Ventricular performance and myocardial perfusion in 
obstructive coronary disease 
** P50HL-1 7648-04 0033 Study of ischemic heart disease - 

Data management-Electrocardiographic analysis system 
** P50HL-17648-04 0034 Study of ischemic heart disease - 

Data management-Hemodynamic data 
P50HL-17651-04 0016 Ischemic heart disease specialized 
center of research - Retropertusion of coronary venus 
circulation with therapeutic agents (dogs) 
P50HL-17651-04 0032 Ischemic heart disease specialized 
center of research ■ Cardiovascular surgery core (human, 
dogs) 
P50HL-17651-04 0039 Ischemic heart disease specialized 
center of research ■ Measurement and prediction of infarct 
size (human, dog) 
P50HL- 176 55-04 0011 Study of ischemic heart disease ■ 
Core facility-Cardiovascular nuclear medicine (human, dog) 
** P50HL-17655-04 0012 Study of ischemic heart disease - 

DATA management 
** P50HL-17667-04 0029 Study of ischemic heart disease - 
Computei diagnosis of cardiac arrhythmias after open 
heart surgery (human) 
** P50HL-17669-04 0013 Ischemic heart disease center 

(SCOR) ■ Exercise in patients with ischemic heart disease 
P50HL-17669-04 0023 Ischemic heart disease center 

(SCOR) - Patients with acute myocardial infarction and 
myocardial ischemia (human) 
P50HL-17570-04 0008 Study of ischemic heart disease - 
Surgical treatment of cardiac rhythm disorders (human, 
dogs) 
P50HL-17670-04 0014 Study of ischemic heart disease - 

Real time ultrasound imaging in ischemic heart disease 
(human, dog) 
P50HL-17670-04 0018 Study of ischemic heart disease - 

Core electrocardiogram laboratory (human) 
** ROlHL-17931-04 Normalized body surface potential maps 
(children) 



■lO 

ROIHI 18/6') 04 Studies in \uivivoit ot Itthil •iihylhmin 

(human) 
ROIHI 18/76 04 Prevention ot acuta and lata! 

cardiovascular disease (human) 
ROIHI 187H3 04 Detection and control ol venlriculai 

premature beats (human) 
ROlHt 18805 04 0001 Sudden cardnt dealh and Iht 

onset ol myocardial infarction Predictive value ol 
maximum exercise stiess testing (human) 
ROIHI 18805 04 0005 Sudden caidiac death and the 

onset ot myocaidial infaiction Sudden death suivivoii 
Radionuclide studies (human) 
M ROIHL 18808 04 Piediclion and piewention of sudden 
caidiac death 
ROIHL 18808 04 0001 Piediction and pievention ot 

sudden caidiac death Piognoslic signilicance ol 
piemature ventricular contractions (human) 
•* ROIHL 18808 04 0003 Prediction and prevention of 

sudden cardiac death Technical support (computei) 
POIHL 19717 02 0046 Response ol the lung to injury 

Bioengineeiing section 
ROIHL 20374 03 Myocaidial function Risk factois and 

future CHD (human) 
ROIHL 20632 02 An optimal fetal heart monitor (human) 
ROIHL 20674 02 Evaluation of caidiac function with 

ladioactive liaceis 
ROIHL 20835 02 Signal analysis of tuibulence study in 

blood 
ROIHL 2089503 0001 Cineangiogiaphic studies of 

caidiovasculai system Videodensitometiy and valvular 
leguigitation (human, dogs) 
ROIHL 20895 03 0003 Cineangiogiaphic studies of 

caidiovasculai system Densitometry in coionaiy stenosis 
(human) 
ROlHL-2089503 0005 Cineangiogiaphic studies of 

caidiovasculai system Computeiized axial tomogiaphy- 
Caidiac wall motion and infaiction (dogs) 
R23HL21253-01 Anatomical models in computei aided 

image analysis 
ROIHL 2127801 Abnoimal caidiac wall motion viewed 

ultrasonically (human, dogs, phantoms) 
ROlHL-21654-01 Autonomic deteiminants of airhythmia 

due to ischemia (cats) 
ROlHL-21684-02 0004 Radionuclide infarct sizing and 

therapy evaluation Image analysis -Kinetics of infarction, 
ventricular function (human, animal) 
ROlHL-21684-02 0005 Radionuclide infarct sizing and 

therapy evaluation - Clinical evaluation of radioisotope 
imaging methods for quantifying infarct size 
ROlHL-21690-02 Sequential multinuclide study of acute 

infarction (human, dogs) 
ROlHL-21707-01 Quantification of infarct size by emission 

tomography (human, dogs) 
ROlHL-21710-01 Electrocardiographic methods of 

quantifying infarct size (human, dogs) 
ROlHL-2175102 0003 Thallium and antimyosin in 

ischemia and infarction - Human studies-Ischemia and 
infarction 
** ROlHL-21785-01 Left ventricular wall motion analysis 
ROlHL-21796-01 Applied pulsatile hemodynamics in 
vascular surgery (dogs) 
** ROlHL-21846-01 Cardiac failure detection by radiography 
and optics (monkeys) 
R23HL-22004-01 Imaging and EGG studies in acute and 

chronic IHO (human) 
ROlHL-22321-01 Cardiac output from the 

pneumocardiogram (dogs) 
ROlHL-22326-01 Noninvasive measurement of caidiac 

output (dogs) 
R23HL-22787-01 Caidiac volume by biplane 

echocaidiography (human) 
R01HL-23983-01 Quantitative ladiocaidiogiaphy (human, 

dogs) 
NOlHV-72924-04 Non-invasive detection of atheioscleiotic 

lesions (human, animals) 
NOlHV-72927-00 Systems foi non-invasive detection of 

atheioscleiotic lesions (human) 
NOlHV-72928-04 Develop high resolution ultiasonic 
imaging techniques 
BIOMEDICAL SYSTEMS AUTOMATED, COMPUTER 
ASSISTED MEDICAL DECISION MAKING 
SEE ALSO BIOMEDICAL SYSTEMS AUTOMATED, COMPUTER 
ASSISTED DIAGNOSIS 
M POlHL-04664-18 Caidiovasculai and lung dynamics 
** POlHL-04664-18 0010 Caidiovasculai and lung dynamics 

- Left ventiiculai dynamics (human) 

POlHL-04664-18 0012 Caidiovascular and lung dynamics 

- Quantitative single plane left ventiiculai angiogiaphy 
(human) 

** POlHL-04664-18 0015 Caidiovasculai and lung dynamics 

- Computei system for the caidiovasculai laboratoiy 
POlHL-06350-17 0015 Hemostasis reseaich piogram 

project - Genetics (human) 
ROlHL-07575-15 Analysis of time-coherent cardiovascular 

data 
R01HL-12085-10 Lipoprotein-carbohydrate metabolism 

(human, rats) 
P50HL-14138-05 0014 Center for leseaich on 

atheioscleiosis - Core biostatistics laboratoiy 
P50HL14214-07 0033 Newborn lung center for hyaline 

membiane disease - Statistical modeling, predictive 

classification in clinical management of HMD 

(contd) 



•Excludes routine methodology OR coveis only general projects which preclude indexing at the specific level. 
"Oriented significantly to above subject. 



M Gram has subprojects descnbing specific reseaich aspects, 
See Appendix foi investigators name and giant number. 



Computer- 
Regional 



BIO 

" P60HL17292-04 0029 Vermont Lung Center 

assisted pre-operative evaluation (human) 
** P60HL-1 7292-04 0031 Vermont Lung Center 

respiratory computer network 
P50HL-1 7667-04 0029 Study ot ischemic heart disease ■ 

Computer diagnosis of cardiac arrhythmias after open 

heart surgery (human) 
•* P50HL-17670-04 0001 Study of ischemic heart disease - 

Data management 
ROlHL-22963-01 Symbolic logic analysis of congenital 

heart disease (human) 

BIOMEDICAl SYSTEMS AUTOMATED, COMPUTER 
ASSISTED PATIENT CARE 

SEE ALSO BIOMEDICAL SYSTEMS AUTOMATED. PATIENT 

MONITORING (MONITORING DEVICES) 
SEE ALSO HOSPITALS, INTENSIVE CARE UNITS 
P01HL-06308-18 0044 Mechanisms and therapy of 

circulatory disease - Echocardiography to determine site of 
ectopic impulse formation (human, dogs) 
" POlHL-11310-12 0065 Mechanisms of cardiovascular 

disease ■ Algorithms for arterial pressure by automatic 
vasoactive agents control (human) 
P01HL-12738-I0 0092 Physiologic pharmacology and its 
clinical applications - Subendocardial ischemia following 
open heart surgery (human) 
M POIHL 13737-07 Assisted circulation 

POlHl-13737-07 0013 Assisted circulation - Incorporation 
of sensors (human, dogs) 
** POlHL-13737-07 0025 Assisted circulation - Driving 
system based on quantitative criteria (human dogs) 
*• POlHL-13737-07 0039 Assisted circulation ■ Computer 

controlled intraortic balloon pumping 
** POlHL-16851-04 0012 Human red cell membrane m 

health and disease - Computer unit -Core facility 
P60HL-17269-04 0030 National heart and blood vessel 

research and demonstration center • Cardiovascular 
engineering laboratories (human) 
** P60HL1 7269-04 0031 National heart and blood vessel 

research and demonstration center - Computer-assisted 
data acquisition and clinical data processing 
P60HL17292-04 0029 Vermont Lung Center - Computer- 
assisted pre-operative evaluation (human) 
P50HL-17651-04 0034 Ischemic heart disease specialized 

center of research ■ Core facilities -Data management 
P50HL-1 7667-04 0029 Study of ischemic heart disease ■ 
Computer diagnosis of cardiac arrhythmias after open 
heart surgery (human) 
P50HL-18323-04 0034 SCOR hypertension center - Core- 

Data management 
ROlHL-22517-01 Engineering development of an ultrasonic 
ventilometer (human) 

BIOMEDICAL SYSTEMS AUTOMATED, COMPUTER 
PROCESSING OF CLINICAL DATA 

SEE ALSO BIOMEDICAL SYSTEMS AUTOMATED, COMPUTER 

ASSISTED DIAGNOSIS 
SEE ALSO BIOMEDICAL SYSTEMS AUTOMATED. COMPUTER 
ASSISTED MEDICAL DECISION MAKING 
NOlHB-72982-03 Statistical coordinating center for sickle 

cell disease 
R01HL02254-23 Blood coagulation and hemorrhagic 

disease (human, animals) 
ROlHL-02799-22 Abnormal hemoglobins (human) 
ROlHL-03429-18 Central nervous system and coronary 

heart disease (human) 
POlHL-04664-18 0001 Cardiovascular and lung dynamics 

- X-ray projection image videodensitometry (dogs) 
P01HL0466418 0003 Cardiovascular and lung dynamics 

- X-ray projection image videometry (human, dogs) 
POlHL-04664-18 0005 Cardiovascular and lung dynamics 

- Applications of current research, equipment and 
techniques 

P01HL04664-18 0010 Cardiovascular and lung dynamics 

■ Left ventricular dynamics (human) 
POlHL-04664-18 0011 Cardiovascular and lung dynamics 

• Detection of abnormal segments of the human ventricle 
by measure of asynergy 

POlHL-04664-18 0013 Cardiovascular and lung dynamics 

- Ventricular function in coronary disease using NTG and 
ventriculograms (human) 

P01HL0466418 0014 Cardiovascular and lung dynamics 

• Clinical application of computer analysis of ventricular 
wall motion 

POlHL-04664-18 0015 Cardiovascular and lung dynamics 

- Computer system for the cardiovascular laboratory 
ROlHL-04666-19 Artificially paced hearts-Technology, 

physiology (human, dogs) 
POlHL-0628518 0146 Cardiovascular-respiratory 

physiology and biochemistry - Pathogenesis and detection 

of hypoxic pulmonary edema (human, animals) 
POlHL-06296-18 0003 Cardiovascular and pulmonary 

adaptation to stress - Human exercise studies (human. 

dogs) 
P01HL-06308I8 0010 Mechanisms and therapy of 

circulatory disease - Ventricular arrhythmias during exercise 

to CHD and myocardial ischemia (human) 
P01HL06308-18 0011 Mechanisms and therapy of 

circulatory disease • Blood flow and electrical dysfunction 

in ventricular arrhythmia (human) 
POlHL-06314-17 0065 Immunologic mechanisms in 

cardiovascular disease - Transplantation biology and 

clinical transplantation 



40 

ROlHL-07139-17 Cardiodynamics and metabolism of 

congestive failure (human, dogs) 
ROlHL-07575-15 Analysis of time-coherent cardiovascular 

data 
ROlHL-0947411 Natural history-congenital heart defects- 
Joint study (human) 
ROlHL-1041712 Multiple systems in electrocardiography 

(human) 
ROlHL-107 18-10 Natural history of congenital heart 

defects-Joint study (human) 
POIHLI 1307-12 0002 Biophysical studies in pediatric 

cardiology Cardiac extracellular electrophysiology (human. 

dog, chimpanzee) 
** POlHL-l 1307-12 9001 Biophysical studies in pediatric 

cardiology ■ Core support -computer science 
POlHL-1131012 0071 Mechanisms of cardiovascular 

disease - Electrophysiological studies of atrial flutter 

(human) 
POIHLI 13 10-12 0072 Mechanisms of cardiovascular 

disease - Electrophysiological studies of atrial tachycardia 

with block (human) 
POlHL-1131012 0081 Mechanisms of cardiovascular 

disease ■ Analysis of regional left ventricular function 

(human) 
POlHL-l 13 10-12 0083 Mechanisms of cardiovascular 

disease - Ventricular volume and hemodynamics in adult 

congenital heart disease 
POlHL-11310-12 0084 Mechanisms of cardiovascular 

disease - Evaluation of cardiac function in chronic renal 

failure (human) 
POIHL 11310-12 0092 Mechanisms of cardiovascular 

disease - Exercise electrophysiology (human) 
POIHLI 13 10-12 0093 Mechanisms of cardiovascular 

disease ■ Multiple dipole electrocardiogram project (human, 

dogs) 
POlHL-1131012 9002 Mechanisms of cardiovascular 

disease • Core support-centralized electronic laboratory 
ROlHL-1 1907-08 Mechanisms of physiological responses 

to exercise (human, dogs) 
POlHL-1237310 0014 Cardiopulmonary physiology and 

pathophysiology ■ Analog digital computation and 

simulation facility 
R01HL1254207 Natural history, congenital heart defects- 
Joint study (human) 
P01HL12738-10 0117 Physiologic pharmacology and its 

clinical applications • Ventricular arrhythmias in ischemic 

heart disease (human) 
P01HL13330-08 0062 Mechanical circulatory support - 

CORE facilities 
POlHL-13737-07 0013 Assisted circulation - Incorporation 

of sensors (human, dogs) 
P01HL1373707 0025 Assisted circulation ■ Driving 

system based on quantitative criteria (human, dogs) 

* R01HL13885-08 9002 Cystic fibrosis and pulmonary 

disease ■ Computer core facility (human) 
ROlHL-1397407 Ventricular premature beats and sudden 

coronary death (human) 
P50HL-1413607 0005 Pulmonary SCOR-Airways 

obstructive diseases - Radiographic studies of airways 

obstructive disease (human) 

* P50HL-141 36-07 9001 Pulmonary SCOR-Airways 

obstructive diseases - Biometrics core 
P50HL-14138-05 0014 Center for research on 

atherosclerosis - Core biostatistics laboratory 
P50HL-1413805 0016 Center for research on 

atherosclerosis - Computer analysis of angiograms 

* P50HL-141 59-08 0023 Specialized center of research In 

hypertension - Core computation 
P50HL-14164-07 0039 A/S SCOR-Comparative and 
experimental atherosclerosis - Statistical resource and 
research management unit 
P50HL-141 92-08 0008 Specialized center of research in 
hypertension • New radiographic methods-Recognition of 
renovascular hypertension (human, dog) 
P50HL-142 12-07 0017 Correlated studies of pulmonary 

fibrosis - Biometry core 
P50HL-142 14-07 0033 Newborn lung center for hyaline 

membrane disease - Statistical modeling, predictive 
classification in clinical management of HMD 
P50HL-14214.07 0036 Newborn lung center for hyaline 

membrane disease • Core-Biomedical engineering 
P50HL-142 18-07 0011 Pulmonary SCOR-Newborn lung 

center - Administrative and computer core 
P50HL-142 18-07 0012 Pulmonary SCOR-Newborn lung 

center - Longitudinal study of RDS-On-line fetal and 
neonatal monitoring (human) 
ROlHL-143 78-07 Lipemias and reconstructive cardiac 

surgery (human) 
POlHL-14388-07 0183 Regulation of the circulation in 

pathological states - Vasopressin in cardiovascular 
regulation (dogs, rats) 
P01HL144 14-07 0007 Environmental influences on 
cardiorespiratory and cellular functions - Neural control of 
respiration (human, cats) 
R01HL14688-05 Myocardial assessment by inverse 

electrocardiography (monkey) 
R01HL1504706 Digital computer analysis of the 

electrocardiogram (human) 
P60HL151 57-07 0002 Comprehensive center for sickle 

cell disease - Central data bank and research file 
P60HL15160-07 0009 Center for sickle cell disease - 
Natural history of sickle cell disease (human) 



Computer controlled two dimensional 
Mathematical models for studying sickle- 
Structure and function of blood proteins 
Innervation of coronary arteries and heart 
Ultrasonic measurement of cardiac 



•Excludes routine methodology OR covers only general projects which preclude indexing at the specific level 
Oriented significantly to above subject. 



M Grant has subproiects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



BIO 

ROlHL-15190-07 Physiological basis of arrhythmias and 

their therapy (human) 
P01HL1526505 0011 Program on surgical control of the 

hyperlipidemias - Central electrocardiography laboratory 
(human) 
■* P50HL- 15389-0 7 0020 Pulmonary SCOR-Hypersensitivity 

pneumonitis - Computer applications and data analysis 
core 
ROlHL-15390-12 Regulation of blood flow in the 

microcirculation 
ROlHL-15676-06 The role of occult myocardial failure in 

human shock (human, dogs) 
P60HL-16005-05 0018 Comprehensive sickle cell center - 
Comprehensive study-Natural history of sickle cell disease 
in adults (human) 
P60HL-16008-06 0012 Wayne State University 
comprehensive sickle cell center - Central data 
management -Computer system 
ROlHL-16403-05 Prognostication by computer-Analyzed 

vectorcardiogram (human) 
R01HL1646105 Late results of valve replacement- 
Computer analysis (human) 
R01HL1648404 Radiographic vcntriculometry for coronary 

heart disease (human) 
ROlHL-1648705 

echocardiography 
R01HL1658004 

cell disease 
ROlHL-16601-05 

(human, cattle) 
R01HL1665706 

(rats) 
R01HL16759-05 

geometry and flow 
ROlHL-16791-03 Computer linkage for a dual camera 

system 
R01HL16901-05 Multipolar linkage between heart 

geometry and surface (human, dogs) 
POlHL-16910-05 0007 Regulation of the peripheral 
circulation - CNS -Behavioral influences on circulation 
(baboons) 
' P60HL-1 7269-04 0031 National heart and blood vessel 
research and demonstration center - Computer-assisted 
data acquisition and clinical data processing 
P60HL- 17292-04 0031 Vermont Lung Center - Regional 

respiratory computer network 
ROlHL-17358-04 Ventilatory adjustments for optimal 

oxygenation (dogs, rats) 
R01HL1757804 Exercise performance in children with 

heart disease 
R01HL-17604-03 Wearable blood pressure and ECG 

recording system 
P50HL-17646-04 0002 Study of ischemic heart disease - 

Core data management 
P50HL-17646-04 0010 Study of ischemic heart disease ■ 
Compliance in ischemic myocardium-Altered cardiac 
performance (human, dogs) 
P50HL-17648-04 0032 Study of ischemic heart disease - 

Data management-Statistics and data files 
P50HL-17648-04 0033 Study of ischemic heart disease ■ 

Data management-Electrocardiographic analysis system 
P50HL-1 7648-04 0034 Study of ischemic heart disease • 

Data management-Hemodynamic data 
P50HL-17651-04 0033 Ischemic heart disease specialized 

center of research - Core facilities -Computer sciences 
P50HL-1765104 0034 Ischemic heart disease specialized 

center of research - Core facilities -Data management 
P50HL-17655-04 0012 Study of ischemic heart disease - 

DATA management 
P50HL-17665-04 0018 Study of ischemic heart disease - 
Computer correlation of data-Patients with ischemic heart 
disease 
P50HL-1766504 0027 Study of ischemic heart disease - 
Positron imaging of regional myocardial perfusion (human, 
dog) 
P50HL-1 7665-04 0030 Study of ischemic heart disease - 

Data management 
P50HL-17667-04 0001 Study of ischemic heart disease - 

Natural history of ischemic heart disease (human) 
P50HL- 17667-04 0030 Study of ischemic heart disease - 

Computerized clinical data acquisition and processing 
P50HL-17667-04 0039 Study of ischemic heart disease - 

Core human investigative laboratories 
P50HL-1 7667-04 0041 Study of ischemic heart disease - 

Biophysical sciences core-Data collection and retrieval 
P50HL17667-04 0042 Study of ischemic heart disease ■ 

Core-Central instrumentation and software 
P50HL-1 7667-04 0044 Study of ischemic heart disease ■ 

Core-Data management and analysis 
P50HL-17670-04 0001 Study of ischemic heart disease ■ 

Data management 
P50HL-1 7670-04 0008 Study of ischemic heart disease - 
Surgical treatment of cardiac rhythm disorders (human, 
dogs) 
P50HL17670-04 0014 Study of ischemic heart disease ■ 

Real time ultrasound imaging in ischemic heart disease 
(human, dog) 
P50HL-17670-04 0018 Study of ischemic heart disease - 

Core electrocardiogram laboratory (human) 
P50HL-17682-04 0009 Study of ischemic heart disease - 
Computer core unit 

(contd) 



BIO 



POIHI 1/'3I 04 0006 Physiological b»Ms ol pulmoniiY 

dliHse Vantiltlion ptilusion latios (human, dots) 
POIHI \Ui\ 04 OOU Physiological biiMS ol pulmomiy 

diseasa SlalistitJ and computing Coi« 
ROIMI 17993 04 000.' Vonliiculai dynamics lioiii 
surgically inserted maikeis Ult venliicio (unction in 
human caidiac allotiatt 
ROIHI 18144 03 Piepiocessoi sys(«im loi caidiogums 

(human) 
PSOHl 18318 03 0001 Pathogenesis and complications ol 

hypertension Coie clinical piogiam 
PbOHl 18323 04 0033 SCOR hypertension center Cote 
lalwratory Renin, aldosterone and bradykinin methodology 
• PMHl 183?3 04 0034 SCOR hypertension center Core 

Data management 
ROIHI 18672 03 Dynamic studies ol clot structure 

formation (human) 
ROIHI 1877604 Prevention ot acute and (atal 

cardiovascular disease (human) 
ROIHI 1880804 0001 Prediction and prevention of 
sudden cardiac death Prognostic signilicance ol 
premature ventricular contractions (human) 
ROIHL 1880804 0003 Prediction and prevention of 
sudden cardiac death Technical support (computer) 
ROIHI 1896803 Computer technology lor transaxial 

tomography 
ROIHL 19053 03 Vascular anatomy of the telencephalon 

(human) 
P50H1. 19153 02 0008 SCOR Pulmonary edemas Eitology, 
pathogenesis Core Biomedical engineering 
*• P50HL 1917002 0010 Harvard pulmonary SCOR Chronic 
diseases of the airways Computer Core 
P50HL 19362 02 0017 A/S SCOR Atherosclerosis in 
nonhuman primates Core laboratory- Data management, 
statistical analysis 
ROIHL 1940603 Grading of atherosclerosis by CW dopplei 

ultrasound (human, dogs) 
ROIHL 19451 03 0001 Functional characteristics of the 

left heart Ventricular performance using epicardial 
radiopaque markers (human) 
R01HL19451-03 0003 functional characteristics of the 
left heart ■ Left ventricular segmental contraction (human, 
dogs) 
R01HL19451-03 0004 Functional characteristics of the 

left heart - Quantitative coronary arteriography (human) 
P01HL1971702 0044 Response of the lung to injury • 

Lung sound analysis (human) 
R01HL1979102 Ultrasonic monitoring visceral blood 

vessels 
R01HL1986403 0002 Blood pressure of children and 

young adults ■ Data epidemiology center 
ROlHL-2027402 Gated imaging with the MGH x-ray 

camera 
ROlHL-2035602 Development and evaluation of an 

artificial heart (calves) 
ROlHL-20597-02 Electrophysiologic correlates of 

myocardial ischemia (human, dogs, rabbits) 
ROlHL-20677-02 Radionuclide studies in congenital heart 

disease 
ROlHL-20724-01 Behavioral consequences of hypertension 

(human) 
ROlHL-20751-01 High speed liquid chromatography of 

hemoglobins (human) 
ROlHL-21052-01 Evaluation of a digitalis therapy advisor 
R01HL-21088-02 Genetic patterns in deaths from Ml and 

stroke in Utah 
ROlHL-21221-02 Clinical antiarrhythmic and 

pharmacodynamic studies 
R23HL-2125301 Anatomical models in computer-aided 

image analysis 
POlHL-21584-02 0006 Respiratory mechanics in normal 
and abnormal states - Respiratory mechanics in health and 
disease (human, pigs) 
*• P01HL-2158402 9002 Respiratory mechanics in normal 

and abnormal states - Computational and statistical core 
facility 
ROlHL-22636-01 Newborn lung function during 

mechanical ventilation (human) 
NOlHR-62901-04 Measure pulmonary function in infants 

and children (also dogs, rabbits) 
NOlHV-12156-10 Lipid research clinic 
NOIHV-12158-10 Establishment of a lipid research clinic 
NOlHV-12159-09 Lipid research clinic 
NOlHV-12160-15 Establishment of a lipid research clinic 
N01HV-22914-08 Establishment of a lipid research clinic 
NOlHV-32931-09 Establishment of a lipid research clinic 

center 
NOlHV-53015-09 Establishment of a lipid research clinic 

(human) 
NOlHV-72927-00 Systems for non-invasive detection of 

atherosclerotic lesions (human) 
N01HV-72928-04 Develop high resolution ultrasonic 
imaging techniques 
BIOMEDICAL SYSTEMS AUTOMATED, COMPUTER 
PROCESSING OF LABORATORY DATA 
(GENERAL) 
ROlHL-01015-27 Hypertension and left ventricular 

hypertrophy (dogs) 
R01HL-02363-20 Kinetics of water and electrolytes in 
shock (dogs, rats) 



41 

POIHI 04664 IB 0001 Cardiovascular and lung dynamics 

X ray pro|mlion image vldeodensilumetry (dog%) 
POIHI 0(i?8;i 18 0173 Ciidioviscular respiratory 

physiology and biochemistry Skeletal and cardiac muscle 
lunction 
POIHI 06296 18 0007 Cardiovascular and pulmonaiy 

adaptation to stress Cardiovascular control during 
isometric exercise (cats) 
ROIHt u;;23 I'j Retlex control of vascular capacitance in 

shock 
ROIHI 0/8/8 16 Metabolism of neutral sterols (rats. 

rabbits) 
POIHI 08214 15 0006 Chemical and biological properties 

ol lipids Analysis and properties of lipids 
' POIHI 08805 15 0043 Regulation of ventilation and 

pulmonary circulation Computer core lacility 
POIHL 08899 14 0028 Tolerance to respiratory gases in 

health and disease Inert gas exchange, oxygen influences 
organs and tissues (human, rabbits, dogs) 
ROIHI 09921 13 Mechanisms related to congestive heart 

failure (dogs, human, rat) 
ROIHL 10330 11 Physiological mechanics of the heart and 

arteries (dogs, rabbits, horses) 
ROIHL 10881 13 Structure and function of 
microcirculation (hamsters, rats, cats, dogs) 
• POIHL 11307 12 9001 Biophysical studies in pediatric 

cardiology Core support computer science 
POIHL 11307-12 9002 Biophysical studies in pediatric 

cardiology Biomedical engineering 
POIHL 11310 12 0093 Mechanisms of cardiovascular 

disease Multiple dipole electrocardiogram proiect (human, 
dogs) 
POIHL 12373 10 0014 Cardiopulmonary physiology and 

pathophysiology Analog digital computation and 
simulation facility 
ROlHL-12711 09 Mathematical approach to cardiovascular 

mechanics (human, animals) 
POIHL 12738 10 0044 Physiologic pharmacology and its 

clinical applications Cardioactive drugs and 
electrophysiological properties of cardiac cells (sheep) 
ROIHL 12879-09 0010 Pulmonary transport and 
metabolism in vivo - Lung morphometry in control and 
edematous lungs (dogs) 
ROIHL 13036-08 Coronary thrombosis-Effects on 
myocardium and in vivo detection (dogs, monkeys) 
ROlHL-13187-09 Central neural control of cardiovascular 

function (cats) 
POlHL-13480-09 0017 Cardiac electrophysiology - Body 

surface potential mapping (human, dogs) 
** POlHL-1348009 0032 Cardiac electrophysiology Cardiac 

activation sequence (dogs) 
POlHL-13737-07 0007 Assisted circulation - 

Determination of cardiac status by use of balloon pump 
(dogs) 
POlHL-1373707 0034 Assisted circulation - Phasic aortic 

flow and cardiac output from phasic pressures (dogs) 
POlHL-13737-07 0035 Assisted circulation ■ Mapping the 

geometry and elasticity of the aorta 
POlHL-1373808 0005 Cardiac assist devices and 
artificial hearts - Development of new materials for 
artificial heart and assist devices (sheep, dog) 
ROlHL-13917-20 Secretion and effects of adrenal 

hormones (human, rabbits, sheep) 
P50HL-141 59-08 0023 Specialized center of research in 

hypertension - Core computation 
POlHL-14388-07 0214 Regulation of the circulation in 

pathological states - Deformation pattern and stress 
analysis of the left ventricle 
POlHL-14388-07 0215 Regulation of the circulation in 

pathological states - Left ventricle model in 
pathophysiologic states 
POlHL-14388-07 0217 Regulation of the circulation in 

pathological states ■ Fluid mechanics of aortic flow (dogs, 
human) 
** POlHL-1441407 9001 Environmental influences on 

cardiorespiratory and cellular functions ■ Laboratory core 
facility 
** P01HL-U4 14-07 9002 Environmental influences on 

cardiorespiratory and cellular functions - Core-Computer 
facility 
R01HL1464507 Blood flow measurement by ultrasonic 

catheter tip methods (human, dogs) 
P50HL-15092-07 0001 Immune and fibrotic response to 

occupational environments • X-ray diffraction study-Dust 
exposure in asbestos cement products manufacturing 
** P01HL151 9407 9002 Pathophysiology of 

cardiopulmonary dysfunction - Data processing laboratory 
core 
ROlHL-15622-05 Computer simulation in cardiology (rats, 

dogs) 
ROlHL-15698-12 Factors affecting the action of 

anticoagulants (rats, human) 
ROlHL-15799-04 Effect of anesthetics on myocardial 

function (cats) 
P60HL-16005-05 0015 Comprehensive sickle cell center - 

Molecular basis for the sickling phenomenon 
ROlHL-16076-06 Electrophysiology of fibrillation and 

defibrillation (human) 
ROlHL-16093-05 Functional properties of hemoglobin and 
erythrocytes 



HIO 

POIHI 16178 05 0004 Control of ventilation in htallh 

and diwise l»«urotnn»mille(» in the iiipiralory %r»l«<" 
(cats) 
POIHI 168/8 05 000') Control ot venlllalion in hiillh 

and disease Program core 
ROIHI 16901 O'l Multipolar linkage ImIwmii hml 

geometry and surlato (human, dogs) 
POIHI 16910 05 0008 Regulation of the ptriphtril 

circulation Circulation to bone (dogs, baboons) 
P60Ht 1/269 04 0016 National heart and blood vejtti 

research and demonstration center New analytical 
methodology lor atherosclerosis studies 
ROIHL 1/452 04 Depolarization inductd cirdiac 

automaticity (human, animals) 
ROIHI 1/532 04 Infarct si« ECG. angio, path, orrelalion 

in dogs 
ROIHL 17592 03 Activation and contraction heal in 

enlarged hearts (rabbits) 
ROIHL 17702 04 Electro optical dyes as probes c( heart 

excitability 
POIHL 1//3I 04 0002 Physiological basis of pulmonary 

disease Biomechanics of the lung (frogs, cats) 
POIHL 17731 04 0012 Physiological basis ol p'llmonary 

disease Statistics and computing Core 
ROIHL 17859 04 Computational methods in cardiac fluid 

dynamics 
ROIHL 1799804 Regulatory mechanisms in blood 

circulation (dogs) 
ROIHL 18156 02 Hemodynamics in curved arteries 
POIHL 18208 04 0002 Center for the study of blood cell 

rheology Holography of RBC shape (human) 
POIHL 18208 04 0005 Center for the study of hlood cell 

rheology RBC deformability and capillary flow 
interrelations (human, mice) 
* POIHL 18575 03 0013 Mechanisms of vascular changes 

in hypertension Biostatistical core 
ROIHL 18794 04 Prospective studies of conduction disease 

(human) 
ROlHL-1886803 Development of vertebrate vascular 

control systems (reptiles, amphibians) 
ROIHL 18969 02 Arterial wall oxygenation (rabbits.' dogs) 
POIHL 18974 03 0017 Experimental neurogenic 

hypertension program Computer physiology core 
ROlHL-19045-03 Electrophysiology of cardiac automaticity 

(human, dogs) 
R01HL19076-03 Vagal control of heart rate- A biophysical 

model (rabbits) 
P50HL-19153-02 0008 SCOR Pulmonary edemas Eitology. 

pathogenesis Core- Biomedical engineering 
ROlHL-19460-03 Mechanics of the papillary muscle and 

the left ventricle (cats, rabbits) 
POlHL-197 17-02 0046 Response of the lung tj injury • 

Bioengineering section 
ROIHL 19824-02 Mass transfer in the mictocir-ulation 
ROIHL 1983002 Shear to aortic histamine synihcsis and 
permeability (dogs) 
** ROlHL-20678-02 Cardiovascular adaptation to stress in 
disease states (dogs) 
R01HL-20800-17 Neural basis of respiratory and 
vasomotor activity (cats) 
** POlHL-21584-02 9002 Respiratory mechanics in normal 

and abnormal states - Computational and statistic-l core 
facility 
ROlHL-21672-01 Antiarrhythmic drug action on VIVIAZ of 

cardiac cells 
ROlHL-21764-01 Ultramicroanalysis of prostaglandins and 

related compounds (rats) 
ROlHL-22136-02 Histamine and cardiac adenyl cyclase 
ROlHL-22223-01 The cardiopulmonary junction (dogs. 

models) 
ROlHL-22329-01 Active prosthetic myocardium-Effects on 

LV function (dogs) 
ROlHL-22562-02 Mechanism of cardiac action potential 

propagation (tunicates) 
NOlHV-32933-07 Hypertension detection and follow-up 
program central laboratory (human) 

BIOMEDICAL SYSTEMS AUTOMATED, 
ELECTRONIC RECORDING SYSTEMS 

POlHL-12373-10 0015 Cardiopulmonary physiology and 

pathophysiology - Cine angiographic-hemodynamic facility 
ROlHL-16759-05 Ultrasonic measurement of cardiac 

geometry and flow 
ROlHL-18040-04 Waveform dependency in defibrillation 
(calves) 
BIOMEDICAL SYSTEMS AUTOMATED, HEALTH 
CARE FACILITIES (SYSTEMS) AUTOMATED 
SEE ALSO BIOMEDICAL SYSTEMS AUTOMATED, COMPUTER 

ASSISTED DIAGNOSIS 
SEE ALSO BIOMEDICAL SYSTEMS AUTOMATED, COMPUTER 

ASSISTED MEDICAL DECISION MAKING 
SEE ALSO BIOMEDICAL SYSTEMS AUTOMATED, COMPUTER 

ASSISTED PATIENT CARE 
SEE ALSO BIOMEDICAL SYSTEMS AUTOMATED. COMPUTER 

PROCESSING OF CLINICAL DATA 
SEE ALSO BIOMEDICAL SYSTEMS AUTOMATED, PATIENT 

MONITORING (MONITORING DEVICES) 
R01HL16791-03 Computer linkage for a dual camera 
system 



:fntd) 



•Excludes routine methodology OR covers only general projects which preclude indexing at the specific level. 
**Oriented signitlcantty to above subject. 



M Grant has subproiects describing specific research aspects. 
See Appendix for Investigator's name and grant number. 



Vermont Lung Center - Health 
Study of ischemic heart disease 



BIO 

BIOMEDICAL SYSTEMS AUTOMATED, HEALTH 
CARE FACILITIES (SYSTEMS) INFORMATION 
SYSTEMS 

SEE ALSO HEALTH RECORDS (SYSTEMS) AUTOMATED 
P01HL0901M5 0017 A research and resource program 

in blood - Operations research laboratory 
** P01HL10436-13 0009 A multidisciplinary study of 

congenital heart disease • Pathophysiology and 

morphogenesis of congenital heart disease (human) 
R01HL-1388108 The American Red Cross National 

Fractionation Center 
" P50HL-1423605 0010 Prevention of premature 

arteriosclerosis ■ Computer programs 
** P60HL-1515707 0002 Comprehensive center for sickle 

cell disease ■ Central data bank and research file 
P60HL-15168-D7 0002 Comprehensive sickle cell disease 

center ■ Patient care 
** P01HL15265-05 0004 Program on surgical control of the 

hyperhpidemlas - Coordinating center and central data 

processing facility 
** P60HL- 16008-06 0012 Wayne State University 

comprehensive sickle cell center • Central data 

management-Computer system 
R01HL1679103 Computer linkage for a dual camera 

system 
P60HL17265-04 0001 Community blood resource center 

support - Demonstration and evaluation 
** P60HL- 17269-04 0031 National heart and blood vessel 

research and demonstration center - Computer-assisted 

data acquisition and clinical data processing 
" P60HL- 17292-04 0023 

information resources 
** P50HL-17646-04 0002 

Core data management 
" P50HL- 1765 1-04 0034 Ischemic heart disease specialized 

center of research ■ Core facilities -Data management 
** P50HL1765504 0012 Study of ischemic heart disease ■ 

DATA management 
" P50HL-17665-04 0018 Study of ischemic heart disease - 

Computer correlation of data-Patients with Ischemic heart 

disease 
** P50HL1766504 0030 Study of ischemic heart disease ■ 

Data management 
** P50HL-1 7667-04 0001 Study of ischemic heart disease - 

Natural history of Ischemic heart disease (human) 
** P50HL1 7667-04 0030 Study of Ischemic heart disease - 

Computerized clinical data acquisition and processing 
P50HL-1 7667-04 0038 Study of ischemic heart disease - 

Clinical core unit 
" P50HL-17667-04 0041 Study of Ischemic heart disease - 

Biophysical sciences core-Data collection and retrieval 
** P50HL1766704 0042 Study of ischemic heart disease - 

Core -Central instrumentation and software 
** P50HL-17667 04 0044 Study of ischemic heart disease ■ 

Core -Data management and analysis 
" P50HL-1 7670-04 0001 

Data management 
** P50HL17682-04 0009 
Computer core unit 
" P50HL-18323-04 0034 
Data management 
NOlHV-22914-08 Establishment of a lipid research clinic 
NOIHV 32973-12 Coordinating center for collaborative 
studies on coronary artery surgery 

BIOMEDICAL SYSTEMS AUTOMATED, MAGNETIC 
RECORDING SYSTEMS 

" POIHL 12738-10 0128 Physiologic pharmacology and Its 
clinical applications - Recording electrograms from 
specialized cardiac tissues (human, dogs) 
R01HL16791-03 Computer linkage for a dual camera 
system 

BIOMEDICAL SYSTEMS AUTOMATED, 
MONITORING DEVICES 

SEE ALSO AIR SAMPLING-MONITORING 

SEE ALSO BIOMEDICAL SYSTEMS AUTOMATED PATIENT 
MONITORING (MONITORING DEVICES) 

SEE ALSO HEART DISORDERS DIAGNOSIS 

ELECTROCARDIOGRAPHY MONITOR* 
ROlHL-01015-27 Hypertension and left ventricular 

hypertrophy (dogs) 
R01HL-n945-10 Synthesis of artificial lung and kidney 

systems (sheep, mice, swine) 
POlHL-13330-08 0034 Mechanical circulatory support ■ In 

vivo test and evaluation of left ventricular bypass pumps 

(human, cattle) 
P01HL13330-08 0062 Mechanical circulatory support - 

CORE facilities 
ROlHL-13426-09 Left ventricular bypass for myocardial 

infarction (cattle, human) 
ROIHL-13988-07 Elimination of reoperative cardiac 

pacemaker surgery (dogs) 
** ROlHL-16292-05 0020 Surgery and non-obstructive 

coronary insufficiency ■ Limitation of transthoracic ECG In 

detecting subendocardial ischemia (dogs) 
** ROIHL-16292-05 0021 Surgery and non-obstructive 

coronary insufficiency ■ Pulsatile assistance on 

subendocardial perfusion during bypass (dogs) 
ROIHL 1648705 Computer controlled two dimensional 

echocardiography 



Study of ischemic heart disease ■ 
Study of Ischemic heart disease - 
SCOR hypertension center - Core- 



42 

** P60HL- 17269-04 0030 National heart and blood vessel 

research and demonstration center ■ Cardiovascular 

engineering laboratories (human) 
P50HL-17682-04 0014 Study of Ischemic heart disease ■ 

Myocardial Ischemia -Instrumentation and technique (dogs. 

baboons) 
P50HL- 17682-04 0015 Study of ischemic heart disease - 

Acute myocardial ischemia and Infarction and their 

reversibility (dogs, baboons) 
ROIHL- 18084-03 Artificial heart and related problems 

(calves) 
ROlHL-18947-02 Indirect mean arterial pressure 

(mammals) 
P50HL-19187-02 0009 Pediatric pulmonary SCOR -Hyaline 

membrane disease - Noninvasive measurement and 

monitoring of arterial oxygen tension (dogs, sheep) 
ROlHL-19678-01 Quantification of intrathoracic fluid by 

Impedance (human, dogs) 
ROlHL-20354-02 Direct determination of oxygen tension in 

the clinical environment (human, dogs) 
ROlHL-20356-02 Development and evaluation of an 

artificial heart (calves) 
ROlHL-20632-02 An optimal fetal heart monitor (human) 
ROlHL-22274-01 Quantltating In series effects In cardiac 

arrhythmias (dogs) 
ROlHL-22604-01 Non-invasive system for arteriosclerosis 

studies (human) 
** ROlHL-22854-01 Non-Invasive blood pressure 

measurement (rats) 
N01HR-62920-02 Noninvasive diagnosis of pulmonary 

hypertension (dog, human) 

BIOMEDICAL SYSTEMS AUTOMATED, PATIENT 
MONITORING (MONITORING DEVICES) 

SEE ALSO HEART DISORDERS DIAGNOSIS, 

ELECTROCARDIOGRAPHY MONITOR* 
SEE ALSO HOSPITALS, INTENSIVE CARE UNITS 
ROlHL-09609-11 Lung volume and breathing mechanics 

during anesthesia (human) 
POlHL-1 1310-12 0058 Mechanisms of cardiovascular 
disease Dynamic response to vasodilating agents 
postoperatively (human) 
ROlHL-13341-06 Lymph -An Indication of splanchnic tissue 

respiration (dogs, human, rats) 
ROlHL-13974-07 Ventricular premature beats and sudden 

coronary death (human) 
P50HL-1421407 0036 Newborn lung center for hyaline 
membrane disease Core-Blomedical engineering 
** P50HL-14218-07 0012 Pulmonary SCOR -Newborn lung 
center - Longitudinal study of RDS -On line fetal and 
neonatal monitoring (human) 
** P50HL-14218-07 0013 Pulmonary SCOR-Newborn lung 
center - Longitudinal study of RDS -Monitoring fetal P02 
and PC02 during labor (human) 
** P50HL-14218-07 0014 Pulmonary SCOR-Newborn lung 
center - Longitudinal study of RDS-MonitorIng fetal 
breathing movements (human) 
ROlHL-16487-05 Computer controlled two dimensional 

echocardiography 
ROlHL-16830-05 Noninvasive determination of aortic 
blood velocities (human) 
** R01HL-17604-03 Wearable blood pressure and ECG 
recording system 
P50HL-1 7646-04 0001 Study of Ischemic heart disease - 

Core clinical Investigation unit 
P50HL-1 7646-04 0002 Study of Ischemic heart disease - 
Core data management 
** P50HL- 17648-04 0033 Study of ischemic heart disease - 
Data management -Electrocardiographic analysis system 
P50HL-1 7651-04 0033 Ischemic heart disease specialized 

center of research ■ Core facilities-Computer sciences 
P50HL-1765104 0035 Ischemic heart disease specialized 
center of research - Core facllitles-Biomedical engineering, 
biophysics 
♦* P50HL-17651-04 0047 Ischemic heart disease specialized 
center of research - Clinical core -Automated arrtiythmia 
monitoring system 
P50HL1766504 0030 Study of Ischemic heart disease - 
Data management 
** P50HL 17667-04 0018 Study of Ischemic heart disease ■ 
Arrhythmias in ischemic heart disease (human) 
P50HL1766704 0029 Study of ischemic heart disease - 
Computer diagnosis of cardiac arrhythmias after open 
heart surgery (human) 
'* P50HL-17667-04 0030 Study of ischemic heart disease - 
Computerized clinical data acquisition and processing 
P50HL-17667-04 0039 Study of ischemic heart disease - 

Core human Investigative laboratories 
P50HL-17667-04 0042 Study of ischemic heart disease ■ 

Core -Central instrumentation and software 
P50HL1 7682-04 0008 Study of ischemic heart disease - 

Clinical core unit 
P50HL-1 7682-04 0009 Study of ischemic heart disease - 

Computer core unit 
ROlHL-18710-02 Non-invasive reflection oximetry In 

peripheral tissue (dogs) 
P50HL-1919002 0001 Pulmonary SCOR -Pathophysiology, 
management of IRDS - Core-Clinical research center 
(infants) 
* P50HL-19190-02 0009 
management of IRDS 



Pulmonary SCOR-Pathophysiology, 
Developing non-invasive neonatal 



pulmonary monitoring systems (rabbit, human) 



•ExclucJes routine methodology OR covets only general projects wtiich preclude indexing 
■•Oriented significantly to above subject 



at the specific level. 



M Grant lias subprojects describing specific researcli aspects. 
See Appendix tor investigator's name and grant number. 



BIO 

R01HL-19414-D3 Protection of myocardium during cardiac 

surgery (dogs, cats, human) 
RO 1 HL-19844-02 Behavioral control of essential 

hypertension (human) 
ROIHL 19973-01 Non-invasive sickled cell monitor 

development (human) 

ROlHL-19993-02 Optical detection of platelet aggregates 

(human, baboons) 
R01HL-20024-03 Therapeutic aerosols-Characteristics and 

retention (human, dogs) 
ROlHL-20110-02 Microwave methods of lung water 
measurement (dogs, phantom models) 
** ROlHL-20351-02 A self-calibrating in vivo blood gas 
monitor (dogs. Infants) 
ROlHL-20364-01 Episodic hypertension associated with 

human behavior (air traffic controllers) 
ROlHL-22321-01 Cardiac output from the 
pneumocardiogram (dogs) 
** ROlHL-22417-01 Microprocessors In medical applications 

(dogs) 
** ROlHL-22517-01 Engineering development of an ultrasonic 

ventllometer (human) 
** ROlHL-22636-01 Newborn lung function during 

mechanical ventilation (human) 
** ROlHL-228 15-01 Regional myocardial function after 
revascularization (dogs) 

BIOMEDICAL SYSTEMS AUTOMATED, 
TELEMEDICINE (GENERAL) 

SEE ALSO BIOMEDICAL SYSTEMS AUTOMATED TELEMETERING 
AND REMOTE SENSING 

SEE ALSO ELECTRONIC STIMULATORS, RAOIOFREQUENCY 
CONTROLLED 
ROlHL-0465119 Remote stimulation by radio-frequency 

transmission (dogs, human) 
R01HL-1679I-03 Computer linkage for a dual camera 

system 
R01HL-18769-04 Studies In survivors of lethal arrhythmias 

(human) 

BIOMEDICAL SYSTEMS AUTOMATED, 
TELEMETERING AND REMOTE SENSING 

M POlHL-13738-08 Cardiac assist devices and artificial 

hearts 
P01HL1373808 0001 Cardiac assist devices and 

artificial hearts - Cardiac assist devices (human, sheep) 
POlHL-13738-08 0002 Cardiac assist devices and 

artificial hearts ■ Total replacement with artificial heart 

(calves, sheep, ponies) 
ROIHL 13988-07 Elimination of reoperative cardiac 

pacemaker surgery (dogs) 
** P50HL-17682-D4 0014 Study of Ischemic heart disease • 

Myocardial ischemia-Instrumentation and technique (dogs, 

baboons) 
P50HL-1 7682-04 0015 Study of Ischemic heart disease - 

Acute myocardial ischemia and infarction and their 

reversibility (dogs, baboons) 

BIOMETRY 

SEE MATHEMATICS, STATISTICS (INCLUDING BIOMETRY) 
BIONOMICS 

SEE PSYCHOLOGY, BEHAVIOR ANIMAL 

BIOPERIODICITY, BIOLOGICAL CLOCKS 

SEE ALSO ENVIRONMENT, ADAPTATION, HIBERNATION 
** POlHL-08682-15 0006 Regulation of the cardiovascular 
system - Cardiovascular studies of mammalian hibernators 
(sciuromorpha) 

BIOPERIODICITY, CIRCADIAN RHYTHMS 

R01HL03303-2I Factors regulating electrolyte excretion by 

the kidney (human, dogs) 
ROlHL-05360-19 Cholesterol biosynthesis and its control 

In liver (rats) 
ROlHL-06975-18 Pathogenesis and prevention of 

hypertension (rats) 
R01HL-0991M2 Hormonal and dietary modification of 

NaCl toxicity (rats) mice) 
ROlHL-10612-13 0018 Humoral factors in heart failure 

and hypertension - The pathogenesis of experimental renal 

hypertension (dogs, rabbits, rats) 
ROlHL-10612-13 0019 Humoral factors in heart failure 

and hypertension • Pathogenesis of hypertension In the 

spontaneous hypertensive rat 
ROlHL-11046-12 Renin, angiotensin, steroids. Ions and 

blood pressure (human, sheep, rabbits) 
ROIHL-13917-20 Secretion and effects of adrenal 

hormones (human, rabbits, sheep) 
P50HL 14141-05 0002 SCOR for atherosclerosis in 

childhood - Intrauterine environment of proband group 

(human) 
R01HL-I5658-05 Intrarenal regulation of sodium 

reabsorption 
ROlHL-1679605 Cholesterol regulation by HMG-CoA 

reductase (rats, human) 
ROlHL-16918-05 Role of steroids In hypertension (human) 
ROlHL-17724-03 Oral contraceptives and hypertension 

(rats) 
P01HL17871-04 0013 Kidney, sodium, cardiac output, 

arterioles and hypertension - Perfusion pressure and renal 

sodium excretion (rats) 
R01HL18730-03 Role of mineralocorticoids in low renin 

hypertension (human, rats) 

(contd) 



BIO 



E>p»tim«nt(l naufogenic 
Modtl ol sustmnad arteiial 



fOlHl 189M 03 0006 

hypertension progiim 

hyptrltnsion (cats) 
ROIHl 1906303 Chol»st«iol and lipoprotein melabolism 

(rat hepatocytes) 
ROIHL 2W7901 Steroids m adrenal legeneralion 

hypertension (rats) 
NOIHR ?29?001 Identity and quantity cystic librosis 

tactois (human) 
BIOPHYSICAL CHEMISTRY (GENERAL)* 

Stt Also BIOPHYSICS AND BIOPHYSICAl CHEMISTRY STUDY 
SECTION 
POIHI 11310 1? 009? Mechanisms ol cardiovascular 

disease Structural tunctional relationships ol neuronal 

differential alloantigens (mice) 
POIHI 11310 12 0098 Mechanisms ol cardiovascular 

disease Protein chemistry ol thy 1 and related 

synaptosomal proteins (mice) 
POIHL 11310 12 0102 Mechanisms ol cardiovascular 

disease Cardiac membrane and ion mobility (dogs) 
•* ROIHL 13198 21 Blood coagulation Physico chemical 

properties (human, cattle) 
** ROIHL 22402 01 Heparin biophysical, chemical and 

biological aspects (mice, human) 
NOIHV 52907 04 Interactions ol platelets with collagens 

(human, mammals) 

BIOPHYSICS (GENERAL)* 

SEE ALSO BIOMEDICAL ENGINEERING 
SEE ALSO PHYSICAL PROPERTIES, RHEOLOGY (NOT INCL. 
BLOOD) 
** P01HL08899 14 0073 Tolerance to respiratory gases in 
health and disease ^ Biophysical mechanisms involved in 
isobaric gas counterdiffuslon syndrome 
** P01HL11310-12 0094 Mechanisms of cardiovascular 
disease Physics of pulsatile fluid flow (dogs) 
POlHL-1131012 0102 Mechanisms of cardiovascular 
disease ■ Cardiac membrane and ion mobility (dogs) 
•* POlHL-1131012 9003 Mechanisms of cardiovascular 

disease - Core support-biophysical sciences 
** R01HL1249410 Continuum mechanics in biophysics 

(human, animals) 
** P01HL1441407 0004 Environmental influences on 

cardiorespiratory and cellular functions Role of diffusion 
in gas exchange (chicken egg) 
** R0]HL-1449505 Solid and structural mechanics of lungs 
(mammals) 
POIHL- 15832-06 0005 Chemical-structural predispositions 
to lung injury Pulmonary structure and stress-strain 
relationships (rats) 
ROlHL-17503-03 Vascular bubbles in decompression 

sickness (minipig, dog, goat) 
R01HL-18676-03 Myocardial sarcomere mechanics (rat) 
Energy output and efficiency of left 



ROlHL-18933-03 
ventricle (dog) 
ROlHL-19647-03 
ROlHL-20079-02 
ROlHL-20105-02 



Therapeutic aerosols 
Thromboresistant material 
Deposition of hygroscopic aerosols in 
bronchi (dogs, human, models) 
** ROlHL-20749-01 Developing heart -Biophysical aspects 

(sheep) 
** ROlHL-20750-01 Studies in sickle cell disease (human) 
ROlHL-22505-01 Molecular pathology of fibrinogen and 
factor XIII (human, animals) 

BIOPHYSICS, BIOMECHANICS 

P0IHL-06664-I7 0042 Cardiopulmonary function in 

remediable vascular disease - Physiologic studies on vein 

grafts (dogs) 
POlHL-1 1310-12 9003 Mechanisms of cardiovascular 

disease - Core support-biophysical sciences 
** POlHL-14388-07 0214 Regulation of the circulation in 

pathological states - Deformation pattern and stress 

analysis of the left ventricle 
** POlHL-14388-07 0215 Regulation of the circulation In 

pathological states - Left ventricle model in 

pathophysiologic states 
POlHL-14388-07 0216 Regulation of the circulation in 

pathological states - Development and regression of 

ventricular hypertrophy (cats, rats) 
POlHL-14388-07 0219 Regulation of the circulation In 

pathological states Myocardial ischemia and infarction in 

animals (dogs) 
** R01HL-14854-07 Lung and tissue mechanics (monkeys, 

dogs) 
P50HL-I9170-02 0006 Harvard pulmonary SCOR -Chronic 

diseases of the airways - Mechanism of overdistension 

(human, animal) 
ROlHL-20163-02 Competitive coronary flow In native and 

graft vessels (dog) 
** ROlHL-20773-02 Surfactant, pulmonary edema, and lung 

mechanics (rabbits) 
ROlHL-21095-02 Enzymes of M tuberculosis and 

obstructive lung disease (human, rodents) 
R01HL-23205-0I Contraction of pulmonary vascular 

smooth muscle (cat) 
ROlHL-23240-01 Pulmonary vascular muscle metabolism 

and contractility (rats, cattle) 



43 

BIOPHYSICS AND BIOPHYSICAl CHEMISTRY 
STUDY SECTION 

•• ROllll OI6t)? n Iquilibiij in Ihc libiinORfn libiiii 

conversion (human cattle) 
•• ROIHI 05556 19 Proteins lipoproteins Sliutluie and 

reactivity (chicken, human, diving mammals) 
•• ROIHI 05949 18 ' 

labbits) 
•• ROIHI 0/451 16 



allostery (human) 
ROIHI 08893 14 

proteins (human) 
ROIHL 09544 I? 

(animals) 
ROIHL 09739 13 
ROIHL 10383 12 



Biochemistry of muscle contraction (rats. 
Hemoglobin S gelation and hemoglobin 
Structure and function of membrane 
Biochemistry of contractile proteins 



Biophysical studies of proteins (human) 
Physical chemical studies of hemoglobins 

and erythrocyte (human) 
ROIHL 11511 10 Structure of ferritin and it» role in iron 

metabolism (horse, rats, human) 
ROIHL 11822 10 Biophysical studies of macromolecular 

interactions (microorganism, human) 
ROIHL 12256 15 Polymerization of sickle cell hemoglobin 

(human) 
ROIHI 1239510 X-ray study of oxygen-carrying cobalt 

complexes 
ROIHL 12524 10 Reaction of hemoglobin with ligands and 

antibodies (human, carp) 
ROIHL 12526 09 Raman spectra of heme proteins and 

related molecules 
ROlHL-12528-10 NMR relaxation of liquid crystal systems 
ROlHL-12760 09 Surface studies of membrane lipids and 

proteins 
ROlHL-13157-09 Molecular oxygen carriers -Synthesis, 

structure, bonding 
ROlHL-13164-07 Interaction of the alpha and beta chains 

of human hemoglobin 
ROIHL 13399-16 Heme protein structure and function 

(human, horse, plants, bacteria) 
ROlHL-13531-06 Coboglobms -Cobalt substituted myo- and 



hemoglobins 
ROlHL-1365208 

(mushroom) 
ROlHL-13909-27 

macromolecules 
ROlHL-13989-05 

structure 
ROlHL-1402006 

platelets (rabbit) 
R01HL14111-07 



Metal sites in metalloproteins 
Physlochemistry and immunology of 
Role of water in respiratiory protein 
Characterization of myosin from blood 



Cholesteryl esters in membranes and 

atherosclerosis (human, swine) 
ROlHL-14271-07 Physico-chemical properties of tracheal 

mucus (dogs, frogs) 
ROlHL-14508-10 Structure and function of respiratory 

hemoprotelns 
R01HL14509-07 Hypertension-Chemistry and biophysics 

of angiotensin 
ROlHL-14680-07 Specific enrichment of myoglobins for 

carbon 13 NMR (catacea) 
ROIHL 14938-06 Contractile proteins of heart muscle 



(dogs, rabbits) 
R01HL15155-05 
ROlHL-15284-06 

studies (human 
ROlHL-15293-07 



Rheology of pulmonary secretions (dogs) 
Hemoglobin and myoglobin kinetic 
animals) 
Sickle cell hemoglobin -Interactions and 

aggregation (human) 
ROlHL-15378-06 Ultrastructure of antihypertensive 

prostaglandins 
ROIHL 15391-07 EPR studies on rotational motion of 

myosin and actin 
ROlHL-15460-06 Molecular adaptation-Hemoglobin 

systems of fish (marine) 
R0IHL-15627-D6 X-ray and chemical studies of 

metalloporphynns 
ROlHL-15648-06 Lipid metabolism -Transport by lateral 

diffusion (human, rabbit, cattle) 
ROlHL-15679-06 Heart and smooth muscle contractile 

protein (swine, cattle, rabbits, chickens) 
ROIHL 15958-06 X-ray diffraction analysis of thrombin 

and neurotoxin 
ROlHL-15980-06 Reactions of hemcprotelns and oxygen 

(cattle) 
ROlHL-16087-05 Structural and dynamic study of model 

heme complexes (yeast) 
ROlHL-1609305 Functional properties of hemoglobin and 

erythrocytes 
R01HL-1610r05 Protein-hpid Interaction (bacteria, 

models) 
ROlHL-16166-05 Structure of alpha-l-antitrvpsin In 

relation to emphysema (human) 
ROlHL-16474-05 Antiblotlc-ion interactions (model 

membranes) 
R01HL-16601-05 Structure and function of blood proteins 

(human, cattle) 
R01HL-1666C-06 Phospholipld-cholesterol and 

phospholipidprotein interactions 
ROlHL-16678-03 Fluorescent probe studies of heart 

muscle proteins (rabbit, dog) 
ROlHL-16860-05 Mossbauer studies of respiratory 

hemoprotelns 
ROlHL-16891-05 The folding of hemoglobin 
ROlHL-16927-05 Structure and function of normal and 

abnormal hemoglobin (human) 



Microcrystallme and crystalline fibrinogen 
Thin filament control ol heart contraction 



BIO 

ROIHI 17411 04 Mokculir iludi<« of red blood cell 

iptctrin (human) 
ROIHI 1/494 0/ Meihanitm ol liqand binding to 

hemoglobin (human) 
ROIHI 1/55901 Mructunl elocidition ol hurt 

cytochrome C oxidate 
ROIHI 1/56/03 lipoprotein cytolytic loiin inltiittion 

(Slaphylococcui aureut. mammals human) 
ROIHI 1/5/103 Study ol membrane permeability by NMR 

lelaialion (human) 
ROIHI 1/5/6 04 Role ol sphingomyelin in biomembrantt 

and bilayers (rah, other mammals) 
' ROIHI 1/826 04 Oxygen delivery to tissue (rat dog) 
' ROIHL 1/82804 Kinetic sludic of hemerythiin reactionj 

(marine worms) 

■ ROIHI 1/8/804 Structural studies ol the human 

erythrocyte membrane 

* ROIHL 18004 02 Transport through arterial wall 

Biophysical aspects (rabbits) 
' ROIHL 1804804 Dynamics of artificial and biological 

membranes (human) 
' ROIHL 1822604 Mechanism of oxygen supply to tissue 

(human, animals) 

■ ROIHL 1825504 Lipid-protem interactions and calcium 

transport (models) 

* ROIHL 18256-01 Optical properties of platelets and 

erythrocytes (rabbits, dogs, human) 

* ROIHL 1827203 Heart adenyl cyclase complex (beef 

heart) 

* ROlHL-18304 03 FT infrared spectroscopy of heart muscle 

energetics (cattle) 

* ROIHL 18309-04 Oxygen transport -Hemoglobins with 

modified hemes (horse) 

* ROIHL 18441 03 Guidelines for polymers acting as elastin 

substitutes 

* ROIHL 18516 03 Atherosclerosis and the arterial 

contractile proteins (pigs, rabbits) 

* ROIHL 18533-03 

(cattle bacteria) 

* R01HL1861203 

(cattle) 

* ROIHL 18619-03 Transferrin iron binding and transport 

properties (chicken, rabbit, human) 

* ROlHL-18623 12 Physical chemistry of biologically active 

lipids (bacteria, plant, cattle, human) 
■* R01HL-18634-03 Quarternary structure of erythro and 

chlorocruorins (invertebrates) 
'* ROlHL-18660-03 

erythrocytes 
'* ROIHL 18725-03 

process (human) 
'* ROlHL-18737-03 Human erythrocyte membrane structure 
'* ROlHL-18746-02 Chemical studies on proteollpid 

apoproteins (cattle) 
** ROlHL-1881804 Stereochemical mechanism of sickling of 

hemoglobin S (human) 
■* R01HL-188I9-07 Chemical studies on sickle cell 

hemoglobin (human) 
** ROlHL-18905-04 Acquisition of native conformation of 

proteins (human, cattle) 
** ROlHL-19065-02 
** ROlHL-19095-03 

(human) 
** ROlHL-19392-03 

metalloproteins 
** ROlHL-19456-03 Immunoglobulins associated with serum 

hyperviscosity (human) 
** ROlHL-19459-03 Dynamics of atherogenesis and 

lipoprotein formation (human, rabbit) 
** ROlHL-19481-03 High field NMR studies of respiratory 

proteins (human, horse, fish, microbes) 
** ROIHL 1948803 Picosecond laser studies of heme- 

protems 
** ROlHL-19491-03 Mechanism of Iron storage and 

mobilization by ferritin (horse) 
** ROlHL-19973-01 Non-mvaslve sickled cell monitor 

development (human) 
** ROlHL-19982-02 Blood coagulation -Protein- metal ion-llpid 

Interactions 
** R01HL-20241-02 Shear and area moduli for abnormal red 

cell membranes (human) 
** ROIHL 20319-02 Assembly, structure and interactions of 

fibrin (human) 
** R01HL20350-02 Crystal structure of llpids-Cholesterol 
** ROlHL-20464-01 Regulation of cardiac and skeletal 

muscle contraction (mammals) 
" ROlHL-20882-02 Interactions of plasma lipoproteins with 

erythrocytes (Rhesus, human) 
** ROlHL-2 11 70-01 Molecular structure of human serum 

transferrin 
** ROlHL-21483-01 Electronic, thermodynamic and kinetics 

of hemoglobin 
" ROlHL-21757-01 Elastin structure -ONA breathing- 
Hemoglobin S gelation 
** ROlHL-21791-01 Precipitation of proteins with poly 

(ethylene glycol) (human) 
" ROlHL-22050-01 Organization of succinic oxidase In heart 
** ROlHL-22052-01 Organization of free cholesterol in serum 

lipoproteins (human, dogs) 
** ROlHL-22081-20 The mechanism of collagen formation 

(human, cattle) 

(conid) 



Neurotransmitter receptors In human 
Light-scattering studies of the sickling 



Molecular oxygen in biological fluids 
Laser spectroscopy of lipoproteins 

Spectroscopic studies ol respiratory 



•Excludes routine melhodoiogy OR covers only general projects which preclude indexing at the specific level 
**Orient€J significantly to above subject 



M Grant has subprojcctsdescnbing specific research aspects 
See Appendix lor investigator's name and grant number. 



BIO 

ROlHL-22194-02 Allostcric function of platelet contractile 
proteins (human) 
" ROlHL-22208-02 Elastin structure, fibrogenesis and 

disease (ctiickens. rabbits) 
** ROlHL-22270-01 Platelet glycoprotein (human) 

ROlHL-22325-01 Thermodynamics in respiratory protein 

binding (human, trout) 
ROlHL-22432-01 Molecular studies of human erythrocyte 

membranes 
ROlHL-22461-01 Cardiac tropomyosm and tropomyosin- 
action interactions (rabbit) 
" ROlHL-2257001 Interactions of sterols in biological 

systems (human) 
** ROIHL 22654 01 Molecular structure of sickle cell fibers 
(human) 
ROlHL-2268201 Structure and function of high density 

lipoprotein (human, rat) 
ROlHL-22771-01 Thrombogenic phospholipid surfaces 
(tattle) 
** ROIHL 22985 01 Properties and assembly of 2-disk 

proteins (human, other species) 
** ROlHL-2300301 Bulk-surface distribution of cholesteryl 

esters 
** ROIHL 23267 01 Rheology and kinetics of hemoglobin S 

gelation (human) 
" ROlHL-2339201 Membrane binding and transport of 

calcium and potassium ionophores 
** ROlHL-2361501 Biochemistry of contractile proteins 
(chicken, rabbit) 

BIOPSY 

SEE DIAGNOSTIC TESTS, BIOPSY* 
BIOSTATISTICS 

SEE MATHEMATICS, STATISTICS (INCLUDING BIOMETRY) 
BIOSYNTHESIS OF CARBOHYDRATES 

SEE CARBOHYDRATES BIOSYNTHESIS 
BIOSYNTHESIS OF FATTY ACIDS 

SEE FATTY ACIDS BIOSYNTHESIS 
BIOSYNTHESIS OF HEMOPROTEINS 

SEE HEMOPROTEINS BIOSYNTHESIS 
BIOSYNTHESIS OF HORMONES 

SEE ENDOCRINOLOGY, HORMONES BIOSYNTHESIS 
BIOSYNTHESIS OF LIPIDS 

SEE LIPIDS METABOLISM, LIPOGENESIS 
BIOSYNTHESIS OF MEMBRANES 

SEE MEMBRANE SYNTHESIS AND RECONSTITUTION 
BIOSYNTHESIS OF NEUROTRANSMITTERS 

SEE NEUROTRANSMITTERS BIOSYNTHESIS 
BIOSYNTHESIS OF NUCLEIC ACIDS 

SEE NUCLEIC ACIDS SYNTHESIS 

BIOSYNTHESIS OF PEPTIDE-POLYPEPTIDE 
HORMONES 

SEE ENDOCRINOLOGY, HORMONES BIOSYNTHESIS, PEPTIDE- 
POLYPEPTIDE HORMONES BIOSYNTHESIS 

BIOSYNTHESIS OF PROTEINS 

SEE PROTEINS BIOSYNTHESIS 

BIOSYNTHESIS OF STEROIDS 

SEE STEROIDOGENESIS 

BIOSYNTHESIS OF VITAMINS 

SEE VITAMINS BIOSYNTHESIS 
BIOTIN 

SEE VITAMIN B, BIOTIN 

BIOTRANSFORMATION (METABOUSM) 

SEE METABOLISM, BIOTRANSFORMATION 

BIPHENYLS, HALOGENATED 

SEE HALOBENZENES, HALOGENATED BIPHENYLS-TRIPHENYLS 
AND ANALOGS 

BIROS* 

SEE ALSO BODY FLUID BALANCE, IONIC, SALT GUND 
** POlHL-0789615 0033 Environmental biorredical research 

program - Breathing mechanism in birds 

BIRDS, CHICK EMBRYO* 

ROlHL-18714-04 Cardiovascular matrix-Morphogenesis 
and maturation (human, chick embryo, mammal) 

BIROS, PIGEONS* 

P50HL-14164-07 0025 A/S SCOR-Comparative and 
experimental atherosclerosis - Animal care resource and 
laboratory animal medicine unit (monkeys, pigeons) 

P50HL14I64-07 0029 A/S SCOR-Comparative and 
experimental atherosclerosis - Development of pigeon 
substrains 
" P50HL-15389-07 0014 Pulmonary SCOR-Hypcrsensitivity 

pneumonitis - Fractionation and characterization of pigeon 
antigens 

BIROS, QUAIL* 

ROlHL-15840-02 Sugar-induced heart lesions and vitamin 
K deficiency (birds, mammals subhuman) 



44 

BIREFRINGENCE 

SEE OPTICS, BIREFRINGENCE* 
BIRTH 

SEE PREGNANCY, BIRTH 
BIRTH CONTROL 

SEE FAMILY PUNNING 
SEE FERTILITY 
SEE PREGNANCY 

BIRTH WEIGHT (ANIMALS) 

SEE AGE (ANIMAL), INFANTS, BIRTH WEIGHT 
BISBENZYLISOQUINOLINES 

SEE OUINOLINES, BISBENZYLISOQUINOLINES 
BISHYDROXYCOUMARIN 

SEE BENZO-ALPHA PYRONES, BISHYDROXYCOUMARIN 
BISULFITES 

SEE SULFITES, BISULFITES 
BLACK AMERICANS 

SEE SOCIAL CROUPS ETHNIC, AMERICANS, BLACK 
AMERICANS 

BLACK LIPID BILAYER MEMBRANE 

SEE BIOLOGICAL TRANSPORT, MEMBRANE MODELS 
BLACK LUNG 

SEE RESPIRATORY DISORDERS, PNEUMOCONIOSIS 
BLACK RACE 

SEE SOCIAL GROUPS, RACIAL STOCKS, BLACK RACE 
BLASTOCYST 

SEE PREGNANCY, EMBRYO-FETUS 
BLEOMYCIN 

SEE ANTIBIOTICS, BLEOMYCIN 
BLOCK ANESTHESIA 

SEE SENSORY DEPRESSION, ANESTHESIA CONDUCTION 
BLOCKING ANTIBODIES 

SEE IMMUNOLOGY, ANTIBODIES, BLOCKING ANTIBODIES 
BLOOD 

SEE BLOOD AND RE SYSTEM, BLOOD* 
BLOOD AND RE DISORDERS, ANEMIA 
SEE ALSO IRON CHELATION THERAPY 
P60HL-151 57-07 0001 Comprehensive center for sickle 

cell disease - Screening program (human) 
P60HL1599905 0019 Miami comprehensive sickle cell 

center - Fetal-adult hemoglobin switch (mouse, monkey) 
ROlHL-16022-05 Determinants of the ventilatory response 
to hypoxia (goats, cats) 
** ROlHL-161 19-05 Spleen and marrow allografts in 
hereditary anemia (mice) 
ROlHL-17462-03 Role of glycosphingolipids in platelet 

aggregation (rats, human, dogs) 
POlHL-17731-04 0010 Physiological basis of pulmonary 

disease - Gas exchange kinetics (dogs) 
ROlHL-18328-03 Hemoglobin function and tissue 

oxygenation (human, dogs) 
R0IHL19270-03 Effects of erythropoiesis on platelets and 

hemostasis (rats) 
ROlHL-22650-01 Regulatory mechanisms of erythropoietin 
production (human, rats, mice) 

BLOOD AND RE DISORDERS, ANEMIA APLASTIC 

NOlHB-62963-03 International bone marrow transplant 

registry 
NOlHB-62964-03 International bone marrow transplant 

registry 
ROlHL-06242-18 Kinetic studies of blood (human) 
ROlHL-20961-02 Hemoglobin Y-chain genes-Evolution and 

inducibility (monkeys, human) 

BLOOD AND RE DISORDERS, ANEMIA APLASTIC 
CONGENITAL 

ROlHL-20899-02 Cellular mechanisms of hemoglobin F 
regulation (human) 

BLOOD AND RE DISORDERS, ANEMIA 
HEMOLYTIC 

SEE ALSO BLOOD GROUP INCOMPATIBILITY 
** ROlHL-07652-14 Destruction of red blood cells in 

hemolytic anemias (human, guinea pigs) 
ROlHL-12944-09 Enzymatic and biochemical studies on 

blood cells (human) 
ROlHL-14131-18 Abnormal hemoglobin syndromes 

(human) 
R01HL15125-07 Molecular pathology of genetic disorders 

in man 
P60HL1600505 0022 Comprehensive sickle cell center - 

Regulation of erythropoiesis in patients with sickle cell 

anemia 
R01HL16421-08 Determinants of RBC deformability and 

capillary flow (human, mice) 
POlHL-16833-04 0011 Hemoglobin and red cell system in 

hemoglobinopathies ■ Relationship between hemoglobin and 

RBC membrane in sickling cells (human, rats) 
ROlHL-18163-04 Red cell membrane effects due to 

oxidizing agents 



BLO 

** POlHL-18208-04 0005 Center for the study of blood cell 

rheology ■ RBC deformability and capillary flow 

interrelations (human, mice) 
ROlHL-19532-01 Oxygen toxicity in the red cell (human) 
P60HL-20985-01 0007 Northern California sickle cell 

center - Immunohematologic abnormalities in sickle cell 

anemia (human) 
•* ROlHL-21159-02 Pathophysiological effects of hypoxia 

(rats) 
ROlHL-2365401 Selected topics on blood transfusion 

(rabbits, human) 

BLOOD AND RE DISORDERS, ANEMIA 
HEMOLYTIC AUTOIMMUNE 

R01HL-1003613 Biology of red cell antigen-antibody 

reaction (human) 
ROlHL-1299409 The Rh complex of red cells (human) 
BLOOD AND RE DISORDERS, ANEMIA 
HEMOLYTIC CONGENITAL (GENERAL) 
SEE ALSO HEMOPROTEINS, HEMOGLOBINOPATHIES 
SEE ALSO METABOLIC DISORDERS INBORN, GLUCOSES- 

PHOSPHATE DEHYDROGENASE DEFICIENCY 
SEE Also MlTAECLIC DISORDERS INBORN, 

PHOSPHOGLYCERATE KINASE DEFICIENCY 
SEE ALSO METABOLIC DISORDERS INBORN, PYRUVATE 
KINASE DEFICIENCY 
ROlHL-07449-17 Formation and survival of red blood cells 

(human) 
ROlHL-12944-09 Enzymatic and biochemical studies on 
blood cells (human) 
** ROlHL-12972-09 Glutathione deficiency in red cells 

(sheep, dogs) 
** R01HL-1993302 Membrane and red cell dysfunction In 
hemolytic anemia (human) 

BLOOD AND RE DISORDERS, ANEMIA 

HEMOLYTIC CONGENITAL, EILIPTOCYTOSIS 
HEREDITARY 

POlHL-18208-04 0005 Center for the study of blood cell 

rheology ■ RBC deformability and capillary flow 
interrelations (human, mice) 

ROlHL-20241-02 Shear and area moduli for abnormal red 
cell membranes (human) 

BLOOD AND RE DISORDERS, ANEMIA 

HEMOLYTIC CONGENITAL, NONSPHEROCYTIC 

SEE ALSO BLOOD AND RE DISORDERS, ANEMIA HEMOLYTIC 
CONGENITAL, ELLIPTOCYTOSIS HEREDITARY 
ROlHL-07449-17 Formation and survival of red blood cells 
(human) 

BLOOD AND RE DISORDERS, ANEMIA 

HEMOLYTIC CONGENITAL, SPHEROCYTOSIS 
HEREDITARY (GENERAL) 

ROlHL-07449-17 Formation and survival of red blood cells 

(human) 
R01HL-16421-08 Determinants of RBC deformability and 

capillary flow (human, mice) 
P01HL-1683304 0011 Hemoglobin and red cell system in 

hemoglobinopathies - Relationship between hemoglobin and 

RBC membrane in sickling cells (human, rats) 
POlHL-18208-04 0001 Center for the study of blood cell 

rheology ■ Physiological basis of reversible erythrocyte 

shape change (human, firefly) 
POlHL-1820804 0005 Center for the study of blood cell 

rheology - RBC deformability and capillary flow 

interrelations (human, mice) 
POlHL-18208-04 0007 Center for the study of blood cell 

rheology - RBC membrane protein (human) 
R01HL1855103 Spectrin, actin. lipid and red cell 

membrane structure 
ROlHL-18660-03 Neurotransmitter receptors in human 

erythrocytes 
ROlHL-20241-02 Shear and area moduli for abnormal red 

cell membranes (human) 
ROlHL-21404-01 Raman spectroscopy of erythrocyte and 

model membranes (human) 
** ROlHL-22432-01 Molecular studies of human erythrocyte 

membranes 

BLOOD AND RE DISORDERS, ANEMIA 
HYPOCHROMIC MICROCYTIC 

SEE ALSO BLOOD AND RE DISORDERS. ANEMIA 
SIDEROBUSTIC 

SEE ALSO HEMOPROTEINS, HEMOGLOBINOPATHIES, 
THALASSEMIA 
ROlHL-06242 18 Kinetic studies of blood (human) 
R01HL07139-17 Cardiodynamics and metabolism of 

congestive failure (human, dogs) 
P60HL1600505 0022 Comprehensive sickle cell center - 

Regulation of erythropoiesis in patients with sickle cell 

anemia 
ROlHL-1667505 Human urinary erythropoietin collection 
ROlHL-1816304 Red cell membrane effects due to 

oxidizing agents 

BLOOD AND RE DISORDERS, ANEMIA 
MEGALOBLASTIC 

P60HL-16005-05 0022 Comprehensive sickle cell center - 
Regulation of erythropoiesis in patients with sickle cell 
anemia 



•Excludes routine methodology OR covers only general projects which preclude indexing at the specific level. 
"Oriented si(nificantly to above subject. 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



(contd) 



•lO 

BLOOD AND RE DISORDERS, ANEMIA 
SIDEROBLASTIC 

ROIHI 20000 03 lion ovtiload in homo/ygous beta 
IhalasstmK (human) 

BLOOD AND RE DISORDERS, BLOOD DISORDERS 

(GENERAL) 

Sll ALSO BLOOD AND Rt OlSORDtRS. ANiMIA 

Sft ALSO BLOOD AND Rt DISORDERS. BONl MARROW 

SEE ALSO BLOOD AND RE DISORDERS. HEMORRHAGIC 

DISORDERS 
SEE ALSO BLOOD AND RE DISORDERS. LEUKOCYTE 

DISORDERS 
SEE ALSO BLOOD COAGULATION DISORDERS 
SEE ALSO BLOOD GROUP INCOMPAIIBIIITY 
SEE ALSO BLOOD PLATELETS DISORDERS 
SEE ALSO BLOOD PROTEINS DISORDERS 
SEE ALSO HEMOPROIEINS. HEMOGLOBINOPATHIES 
SEE ALSO HEMOPROTtlNS. HEMOGLOBINURIA. PAROXYSMAL 

NOCTURNAL 
SEE ALSO HEMOPROTEINS. METHEMOGLOBINEMIA 
SEE ALSO KIDNEY DISORDERS. UREMIA 
•* ROIHI 1283909 Flow, tiansport and membrane 

phenomena in blood (human) 
"* ROIHL 1294409 Enzymatic and biochemical studies on 
blood cells (human) 
ROIHL 1S722 06 Hemorrheology studies related to in vivo 

blood (low (human) 
POIHL 16833 04 Hemoglobin and red cell system in 

hemoglobinopathies 
POIHL 16851 04 Human red cell membrane in health and 
disease 

Human red cell membrane in 
Rheology of erythrocyte membrane 



M 



M 



POlHL-16851 04 0001 
health and disease 
(human, amphiuma) 

POIHL 16851 04 0009 
health and disease - 



Human red cell membrane in 
Blood cell properties in circulatory 

regulation (dogs, rabbits) 
P01HL16851-04 0010 Human red cell membrane in 

health and disease • Core facility-Hematology clinic 
ROlHL-1782103 Cavitation phenomena near prosthetic 

devices 
R01HL17881-15 Biosynthesis and degradation of blood 

group substances (human, animals) 
R01HL'I8163-04 Red cell membrane effects due to 

oxidizing agents 
P01HL18208-04 

rheology 
ROlHL-1916302 

Atlantic cod 
ROlHL-1916403 

Atlantic cod 
R01HL1917303 



Center for the study of blood cell 
Piscine erythrocytic necrosis in the 
Piscine erythrocytic necrosis in the 



Analysis of blood trauma from 
microporous oxygenators (human, dogs, rabbits) 
ROlHL-2030303 Cholesterol distribution in erythrocyte 
membrane (human, animals) 
** ROlHL-22219-01 Prostacyclin and peroxides in blood and 
membrane disease 

BLOOD AND RE DISORDERS, BONE MARROW 

SEE ALSO BLOOD AND RE DISORDERS. ANEMIA APLASTIC 
R23HL-21212-02 Alveolar macrophage function in 
Pseudomonas infection (dgs) 

BLOOD AND RE DISORDERS, BONE MARROW, 
POLYCYTHEMIA 

POlHL-06285-18 0133 Cardiovascular-respiratory 

physiology and biochemistry • Decreased uterine blood flow 
and fetal development (lambs) 
POlHL-0628518 0136 Cardiovascular-respiratory 
physiology and biochemistry - Fetal microcirculation in 
utero (rabbits, lambs) 
** P01HL-11310I2 0095 Mechanisms of cardiovascular 
disease - Blood and transfusion disorders (human, rats, 
monkeys) 
POlHL-14985-07 0003 Adaptation to hypoxia - Hypoxia 
and oxygen transport (human, dogs) 
" P01HL14985-07 0013 Adaptation to hypoxia ■ Chronic 
mountain sickness (men) 



ROlHL-16656-06 

(dogs) 
ROlHL-2 11 59-02 

(rats) 
ROlHL-22650-01 



Left ventricular function in exercise 
Pathophysiological effects of hypoxia 



Regulatory mechanisms of eivthropoietin 
production (human, rats, mice) 

BLOOD AND RE DISORDERS, HEMORRHAGIC 
DISORDERS 

SEE ALSO BLOOD COAGUUTION DISORDERS 
SEE ALSO BLOOD PUTELETS DISORDERS 
SEE ALSO CARDIOVASCUUR DISORDERS. HEMORRHAGE 
SEE ALSO NASAL DISORDERS. EPISTAXIS 
** ROlHL-01601-30 Blood coagulation and hemorrhagic 

disease (horseshoe crabs) 
** ROlHL-01661-27 Hemostatic mechanisms (human) 

ROlHL-02212-23 Coagulation of blood (human) 
** ROlHL-02254-23 Blood coagulation and hemorrhagic 

disease (human, animals) 
** ROlHL-10582-12 Thrombosis and hemostasis-Analysis, 

methods and standards (human, cattle, venom) 
** R01HL13629-08 Hemorrhagic diseases (human) 

ROlHL-14595-07 Primary disorders of platelet function 
(human, rats) 



Collection, function and transfusion of 
The role of leukocytes in thrombotic 



45 

ROIHI 15335 06 The nature of the collagen plattitt 

Milviaction (aniiniM 
ROIIU 1/462 03 Role ol glycotphingolipidt in plll«l«l 

aggregation (i»t\. human, dogi) 
ROlHt 21403 02 Blood clotting kinetics studied by 

iddiuiminunoiis^ny (huinon) 

BLOOD AND RE DISORDERS, LEUKOCYTE 
DISORDERS 

SEE Also IMMUNIIY, IMMUNOIOGICAI UNRf SPONSIVf NFSS 
SEE ALSO MtlABOlIC DISORDERS INBORN. ANGIONEUROTIC 

EDEMA (HEREDITARY) 
SEE ALSO METABOLIC DISORDERS INBORN. CHEOIAK HIGASHI 
SYNDROME 
ROIHL 1666006 Phospholipid cholesterol and 

phospholipid protein interactions 
ROIHL 17437 03 Perfusion lung'-Role ol traumatized 

leukocytes (dogs, human) 
ROIHL 20807 02 Detection of familial hypercholesterolemia 
(human) 
BLOOD AND RE DISORDERS, LEUKOCYTE 
DISORDERS, AGRANULOCYTOSIS 
NOIHB 6297002 Collection, function and transfusion of 

granulocytes 
NOIHB 62973 05 
granulocytes 
•* R01HL14739-06 

disease (human, dogs) 
P01HL1857603 0007 Thrombosis research program 

protect Relationships between coagulability and 
thrombosis (human, animals) 

BLOOD AND RE DISORDERS, LEUKOCYTE 
DISORDERS, LEUKOCYTOSIS 

ROlHL-1568505 Hemopoietic regulators produced in cell 

culture (human, animals) 
POlHL-1864603 0006 Studies basic to heart 

transplantation - Reduction or elimination of existing 

presensitization (human, animals) 

BLOOD AND RE DISORDERS, LEUKOCYTE 
DISORDERS, LEUKOPENIA 

SEE ALSO BLOOD AND RE DISORDERS. LEUKOCYTE 
DISORDERS, AGRANULOCYTOSIS 
** ROlHL-06242-18 Kinetic studies of blood (human) 
ROlHL-15647-06 Hematopoietic studies of cyclic 

hematopoiesis (dogs) 
P60HL-17265-04 0009 Community blood resource center 
support Research -Developing granulocyte transfusion 
therapy (human, rabbit) 
R23HL-2121202 Alveolar macrophage function in 
Pseudomonas infection (dgs) 

BLOOD AND RE DISORDERS, LEUKOCYTE 
DISORDERS, PHAGOCYTE DYSFUNCTION 
(GENERAL) 

** P60HL-16005-05 0020 Comprehensive sickle cell center - 
Studies of the immunologic defect in sickle cell anemia 
(human) 
R23HL19584-01 Alveolar macrophage responses to toxic 
particle exposure (guinea pigs, human) 

BLOOD AND RE DISORDERS, MAST CELL 
HYPERPLASIA 

•* POlHL-14985-07 0010 Adaptation to hypoxia - Pulmonary 
mast cell (animals) 

BLOOD AND RE DISORDERS, SPLENIC 
DISORDERS 

R01HL-19430-03 Congenital heart malformations and 

situs inversus (mice) 
ROlHL-2008602 Circulatory control of splenic function 
(rats) 
BLOOD AND RE DISORDERS, SPLENIC 

DISORDERS, SPLENOMEGALY 
** ROlHL-18997-02 Ischemic therapy in experimental 
hypersplenism (rats, dogs) 
ROlHL-20086-02 Circulatory control of splenic function 
(rats) 
BLOOD AND RE DISORDERS CHEMOTHERAPY 
SEE ALSO BLOOD AND RE SYSTEM PHARMACOLOGY 
SEE ALSO BLOOD COAGULATION. ANTICOAGUUNTS 
SEE ALSO BLOOD COAGULATION, FIBRINOLYTIC AGENTS 
SEE ALSO BLOOD COAGUUTION. HEMOSTATICS 
SEE ALSO HEMOPROTEINS. HEMOGLOBINOPATHIES, SICKLING 

INHIBITORS 
SEE ALSO IRON CHELATION THERAPY 
NOlHB-729 16-02 Crisis and pain symptom prophylaxis by 

oral zinc therapy (human) 
ROlHL-01601-30 Blood coagulation and hemorrhagic 

disease (horseshoe crabs) 
R01HL-02799-22 Abnormal hemoglobins (human) 
P01HL-07896-15 0057 Environmental biomedical research 
program - Effects of dipyridamole and aspirin on 
decompression thrombocytopenia (human) 
ROlHL-1058212 Thrombosis and hemostasis-Analysis, 

methods and standards (human, cattle, venom) 
P01HL11414-11 0004 Thrombosis and atherosclerosis 

program - Platelet function and nonthrombogenic surfaces 
(human) 



BLO 

POIHI II4I4 II 0033 Thiombo-.r. •ml .li.riuv l.iojii 

piogrnrn Human couinarin induced prothromliin 
ROIHt 129/2 09 Glutathione delirieniy in red callt 

(iheep. dog%) 
POIHL 13/38 08 0003 Cardiac ai>iit dtvicet and 

artificial hearts Palhophyiiological •tfectt of the artilirial 
heart (calves) 
•• ROIHL 13/54 08 Postoperative Ihiomboembolism in 
surgical patients (human) 
P60HL 15158 0/ 0011 Compreheniive tickle cell center 

Clinical services Adult patients 
P60HI 15169 05 0018 Support for center lor sickle cell 

disease Studies on sickle cell disease (human rats, 
dogs) 
P60HL 15170 05 0001 Support lor center lor sickle cell 

anemia Adult clinical services 
POIHL 15486 06 0006 Studies on thrombosis Clinical 

investigation unit 
ROIHL 15593 05 Prolonged extracorporeal cardiopulmonary 
support (rats, sheep, rabbits) 
•* POIHL 15596 05 0001 Coagulation, fibrinolysis, 

hemostasis and hepatitis Defibrination (human) 
M P60HL 15999 05 Miami comprehensive sickle cell center 
** P60HL 15999 05 0008 Miami comprehensive sickle cell 

center Cyanate effect on host defense Cellular and 
humoral (human, guinea pig. rabbits) 
ROIHL 1637504 Investigation ol hemoglobin S properties 
(human) 
M POIHL 1743005 Control ol coagulation 
** POIHL 17430 05 0001 Control ol coagulation Porcine 

von Willebrand's disease 
ROIHL 18012 04 Cellular defects in nocturnal 
hemoglobinuria (human) 
M POIHL 1857603 Thrombosis research program project 
POIHL 18576 03 0013 Thrombosis research program 

project Early warning and monitoring lest systems in 
thrombotic disease (human) 
ROlHL-1881503 Surgical vascular disorders (human, 
dogs) 
** ROlHL-18819-07 Chemical studies on sickle cell 
hemoglobin (human) 
ROlHL-2092001 Control of hemoglobin synthesis (baboon) 
R23HL-21212 02 Alveolar macrophage function in 
Pseudomonas infection (dgs) 

BLOOD AND RE DISORDERS CONGENITAL 
(HEREDITARY) 

SEE ALSO BLOOD AND RE DISORDERS. ANEMIA APLASTIC 

CONGENITAL 
SEE ALSO BLOOD AND RE DISORDERS. ANEMIA HEMOLYTIC 

CONGENITAL (GENERAL) 
SEE ALSO BLOOD COAGULATION DISORDERS 
SEE ALSO BLOOD PROTEINS DISORDERS CONGENITAL 
SEE ALSO HEMOPROTEINS, HEMOGLOBINOPATHIES 
SEE ALSO IMMUNOPATHOLOGY, IMMUNOLOGIC DEFICIENCY 
DISORDERS 
R01HL-0ie48-31 Blood coagulation and hemophilia (dogs. 

swine) 
ROlHL-022 12-23 Coagulation of blood (human) 
R01HL02254-23 Blood coagulation and hemorrhagic 

disease (human, animals) 
ROlHL-04366-19 Plasminogen -Activation and structure- 
function relations (mammals, birds) 
** ROlHL-05168-19 Inhomogencity of hemoglobin types 

(human) 
** R01HL-05351-18 Blood group antigens and antibodies 
(human, rabbits, sheep) 
P01HL06314-17 0047 Immunologic mechanisms in 

cardiovascular disease - Role of intravascular coagulation 
(human, animals) 
ROlHL-0916313 Control mechanisms in hemostasis 
(human) 
** R01HL12944-09 Enzymatic and biochemical studies on 

blood cells (human) 
** R01HL13585-05 Heterogeneity of NADH methemoglobin . 
reductase (human) 
ROlHL-14131-18 
(human) 



Abnormal hemoglobin syndromes 
Primary disorders of platelet function 



R01HL14595-07 

(human, rats) 
ROlHL-15647-06 Hematopoietic studies of cyclic 

hematopoiesis (dogs) 
R01HL-16U9-05 Spleen and marrow allografts in 

hereditary anemia (mice) 
ROlHL-17752-03 Purified human clotting factor IX- 

Immunologic studies (human) 
R01HL18507-03 Clinical studies of Fletcher factor 

(human) 
ROlHL-18586-03 Role of platelet lipids in hemostasis and 

thrombosis (human) 
ROlHL-19272-03 Studies on the Passovoy factor (human) 
ROlHL-19646-03 An immunologic study of hemoglobin 

variation in man 
ROlHL-20751-01 High speed liquid chromatography of 

hemoglobins (human) 
ROlHL-20925-01 The acetylation of fetal hemoglobin 

(human) 
POlHL-2101602 0012 Sickle cell anemia and other 

hemoglobinopathies - Stimulation of Hb F synthesis in a 

permanent cell line 
R23HL-21428-02 Expression of human globin in 

thalassemia (human) 

(contd) 



'Excludes routine methodology OR covers only general projects which preclude indexing at the specific level. 
**0nented significantly to at»ve subject. 



M Grant has subprojects descnbing specific research aspects. 
See Appendix for investigator's name and grant number 



BLO 

" ROIHL 21487-01 Molecular characterization of 

Glanzmann's thrombasthenia (human) 
" R01HL-2I975-01 Studies on normal and abnormal factor 

IX (human, dogs, cows) 
R23HL-22621-01 Blood cell-mediated pulmonary (human) 

BLOOD AND RE DISORDERS DIAGNOSIS (INCL 
EXAMS)* 

SEE ALSO BLOOD COAGUUTION TESTS* 
SEE ALSO BLOOD (HEMATOLOGIC) TESTS* 
ROlHL-02212-23 Coagulation of blood (human) 
** P60HL-15157-07 0001 Comprehensive center for sickle 

cell disease - Screening program (human) 
*• P60HL-15158-07 0004 Comprehensive sickle cell center - 

Expression of abnormal hemoglobin synthesis in the 

neonate and young child 
P60HL-15I60-07 0009 Center for sickle cell disease ■ 

Natural history of sickle cell disease (human) 
** P6aHL15160-07 0012 Center for sickle cell disease ■ 

Core laboratories 
** P60HL1516007 0013 Center for sickle cell disease - 

Immunochemical diagnosis of hemoglobinopathies (infants) 
** P60HL-1516007 0017 Center for sickle cell disease - 

Demonstration-Education, screening, counseling, patient 

care 
** P60HL-1516207 0011 Comprehensive sickle cell center - 

Core program-Genetic counseling and diagnostic screening 
** P60HL15162-07 0018 Comprehensive sickle cell center - 

Biochemical and genetic studies of sickle cell anemia 

(human) 
** P60HL-1516807 0001 Comprehensive sickle cell disease 

center - Screening program (human) 
P60HL1516807 0010 Comprehensive sickle cell disease 

center - Sickle cell center project (children) 
M POlHL-1548606 Studies on thrombosis 

POlHL-15486-06 0001 Studies on thrombosis - Studies on 

chemistry of fibrinogen (human, dogs) 
POlHL-15486-06 0002 Studies on thrombosis - 

Characterization of antisera to fibrinopeptlde B (human, 

rabbits) 
** P01HL15596-05 0001 Coagulation, fibrinolysis, 

hemostasis and hepatitis - Defibrination (human) 
ROlHL-15722-06 Hemorrheology studies related to in vivo 

blood flow (human) 
M P60HL15999-05 Miami comprehensive sickle cell center 
** P60HL-15999-05 0004 Miami comprehensive sickle cell 

center - Education, screening and counseling 
** P60HL-16005-05 9001 Comprehensive sickle cell center - 

Core laboratory and counseling (human) 
** P60HL16008-0G 0011 Wayne State University 

comprehensive sickle cell center ■ Education, screening and 

counseling 
** P60HL-16008-06 0020 Wayne State University 

comprehensive sickle cell center - Genetic and physiological 

studies of sickle cell anemia (human) 
** POIHL-16387-04 0005 The blood vessel and 

thrombogenesis - Fluid engineering considerations in 

thrombogenesis 
P01HL-I7419-04 0001 Studies on mechanisms of 

hemostasis - Structure and metabolism of fibrinogen 

(human) 
M POlHL-17430-05 Control of coagulation 
** POlHL-17430-05 0001 Control of coagulation - Porcine 

von Willebrand's disease 
** POIHL 17430-05 0005 Control of coagulation - The 

activation of prothrombin (human, cattle, dogs) 
** POlHL-17430-05 0006 Control of coagulation - Activation 

fragments of prothrombin in vitro and in vivo (human, 

dogs, cattle) 
** R01HL-I7769-03 New methods of studying blood 

coagulation kinetics 
ROIHL 18012-04 Cellular defects in nocturnal 

hemoglobinuria (human) 
M P01HL18576-03 Thrombosis research program project 
*' P01HL18576-03 0013 Thrombosis research program 

proiect Early warning and monitoring test systems in 

thrombotic disease (human) 
ROlHL-1872503 Light-scattering studies of the sickling 

process (human) 
ROIHL 20856-02 Platelet transfusions-Usage and 

complications (human) 
M P60HL-2098501 Northern California sickle cell center 
** P60HL 20985-01 0009 Northern California sickle cell 

center ■ Patient services (children, adults) 
** P60HL-20985-01 0010 Northern California sickle cell 

center Prenatal diagnosis of sickle cell anemia 
P01HL2101602 0017 Sickle cell anemia and other 

hemoglobinopathies ■ The hereditary clinic core 
** P01HL-22I63-01 0002 Surface fhrombogenesis- 

Mechanisms and prevention - Laser-scattering detection of 

microemboli in blood flow (baboons) 
P60HL-2328201 9001 Comprehensive hospital/community 

sickle cell center ■ Core -Institutionalization of education, 

screening and counseling 

BLOOD AND RE DRUGS (GENERAL) 

SEE ALSO BLOOD AND RE SYSTEM, HEMATOPOIETIC FACTORS 

SEE ALSO BLOOD COAGULATION, ANTICOAGUUNTS 

SEE ALSO BLOOD COAGUUTION. ANTIFIBRINOLYTIC AGENTS 

SEE ALSO BLOOD COAGUUTION, FIBRINOLYTIC AGENTS 

SEE ALSO BLOOD COAGUUTION, HEMOSTATICS 

SEE ALSO BLOOD SUBSTITUTES 



46 

SEE ALSO HEMOPROTEINS, HEMOGLOBINOPATHIES, SICKLING 

INHIBITORS 
ROlHL-22338-01 Platelet adhesion and aggregation in a 
flow chamber (human) 

BLOOD AND RE SYSTEM, BLOOD* 

SEE ALSO BLOOD AND RE SYSTEM, HEMATOLOGY 
SEE ALSO BLOOD AND RE SYSTEM, HEMATOPOIESIS 
SEE ALSO BLOOD AND RE SYSTEM, HEMATOPOIETIC TISSUE 
SEE ALSO BLOOD AND RE SYSTEM, IMMUNOHEMATOLOGY 

(GENERAL) 
SEE ALSO BLOOD CELLS 
SEE ALSO BLOOD COAGULATION 
SEE ALSO BLOOD GROUPS 
SEE ALSO BLOOD PRESERVATION 
SEE ALSO BLOOD PROTEINS 
SEE ALSO BLOOD TOXICOLOGY 
SEE ALSO BLOOD TRANSFUSION 

SEE ALSO CARDIOVASCUUR FUNCTION, BLOOD CIRCUUTION 
DYNAMICS (GENERAL) 
** POlHL-03174-23 0010 Mechanisms of acute vascular 
reaction to in|ury - Search for mutagens in the human 
blood (bacteria, animals) 
** P01HL14414-07 0014 Environmental Influences on 

cardiorespiratory and cellular functions - Temperature and 
acid-base status in tissues, cells, and subcellular system 
*' POIHL 15596-05 0016 Coagulation, fibrinolysis, 

hemostasis and hepatitis - Hepatitis-B antigen in whole 
blood, plasma and plasma fractions (human, monkeys) 
** ROlHL-16921-05 Synthetic hydrogels as blood tolerable 
materials 
ROlHL-22406-01 Isobanc vascular bubbles and 
decompression sickness (goats, models) 

BLOOD AND RE SYSTEM, BLOOD, PLASMA 

POlHL-06835-17 0045 Cardiovascular disease ■ Pressure- 

volume-renin relationship in human hypertension 
P01HL06835-17 0046 Cardiovascular disease • Renin 

activity during salt depletion in essential hypertension 

(human) 
ROlHL-13198-21 Blood coagulation-Physico-chemical 

properties (human, cattle) 
POlHL-13262-07 0018 Arterial wall in atherosclerosis - 

Vasoactive factors of human plasma 
P60HL-15I60-07 0014 Center for sickle cell disease - 

Replacement therapy of opsonin deficiency in sickle cell 

anemia (children) 
** POlHL-15596-05 0016 Coagulation, fibrinolysis, 

hemostasis and hepatitis - Hepatitis-B antigen in whole 

blood, plasma and plasma fractions (human, monkeys) 
ROlHL-16346-09 Enzyme assay for blood clotting (human) 
ROlHL-16445-05 Regulation of plasma protein 

biosynthesis (rats, rabbits) 
ROlHL-17487-04 Adrenergic-vasoregulation interactions in 

hypertension (human) 
ROlHL-17847-04 Cardiovascular and renal functions of 

marmots 
P50HL-18828-03 0003 Specialized center of research in 

thrombosis ■ Structure and function of plasma coagulation 

inhibitors (human) 
ROlHL-19320-03 Angiotensin neuropharmacology- 

Relationship to sodium 
ROlHL-20218-02 Fibrinogen catabolism and intravascular 

coagulation (human) 
ROlHL-20301-02 

human blood 



ROlHL-20558-02 
and drugs 

ROlHL-21094-01 
(dogs) 

ROlHL-21139-02 

ROlHL-21239-02 



Genetics of glycosyitransferases In 
Cardiac electrophysiology-Effects of ions 
Arterial baroreceptors and renal function 



Molecular biology of factor XIII (human) 
Isolation and mechanism of action of 
thromboxane A2 (human, rabbits) 
ROlHL-21540-02 Specific inhibitors of coagulation and 

fibrinolysis (rats, rabbits, dogs) 
ROlHL-21764-01 Ultramicroanalysis of prostaglandins and 

related compounds (rats) 
ROIHL-22051-01 
release (human) 



ROlHL-22273-01 

(rats) 
ROlHL-22627-01 



Role of angiotensin II in vasopressin 
Oral and lung absorption of nitroglycerin 



An inhibitor of platelet adhesion to 

artificial organs (human) 
ROlHL-22996-01 Venom proteases-Action on plasma 

protease inhibitors (human) 
ROlHL-23726-01 Treatment of ventricular arrhythmias with 

propranolol (human) 

BLOOD AND RE SYSTEM, BLOOD, SERUM 

SEE ALSO IMMUNOLOGY, ANTIBODIES, IMMUNE SERA 
SEE ALSO IMMUNOLOGY, SEROLOGY* 
ROlHL-06924-16 Humoral and metabolic aspects of 

cardiac function (mammals, non-human, human) 
P01HL-08682-15 0006 Regulation of the cardiovascular 

system ■ Cardiovascular studies of mammalian hibernators 

(sciuromorpha) 
R01HL13885-08 0007 Cystic fibrosis and pulmonary 

disease ■ Alveolar macrophage defense mechanism 

(human, rabbits) 
ROlHL-13885-08 0008 Cystic fibrosis and pulmonary 

disease - Pseudomonas specific activation of alveolar 

macrophages (human, rabbits) 



BLO 

ROlHL-13885-08 0009 Cystic fibrosis and pulmonary 

disease ■ Respiratory mucus glycoproteins (human, rabbits) 
POIHL- 178 12-04 0004 Thrombosis and plasma proteins - 

Serum-platelet interaction (human) 
ROlHL-1906603 Synthesis and evaluation of 

prostaglandin metabolites (guinea pigs) 
P50HL19157-02 0007 Studies in cystic fibrosis and 

bronchiolitis - Analysis of cystic fibrosis factors (human) 
R23HL-21083-02 Pharmacokinetics of digoxin and digitoxin 

in humans (rats) 
R23HL-21411-02 Control of extracellular lysosomal 

hydrolase levels (rats) 
R23HL-2257501 Factors modifying cardiac digoxin effects 

and content (dogs, cats) 
NOlHR-72922-01 Cystic fribrosis factor identicalion and 

quantification (human) 
NOlHR-72923-01 Cystic fibrosis factor identification and 

quantification (human) 

BLOOD AND RE SYSTEM, BLOOD 
FRACTIONATION 

SEE ALSO BLOOD TREATMENT, LEUKAPHERESIS 

SEE ALSO BLOOD TREATMENT, PUSMAPHERESIS 

** ROIHL- 1388 1 -08 The American Red Cross National 

Fractionation Center 
" POlHL-15596-05 0007 Coagulation, fibrinolysis, 
hemostasis and hepatitis - Structural studies and 
fractionation of urokinase (human) 
** POlHL-15596-05 0008 Coagulation, fibrinolysis, 
hemostasis and hepatitis - Structural studies and 
fractionation of antihemophilic factor (human) 
** P01HL15596-05 0016 Coagulation, fibrinolysis, 

hemostasis and hepatitis ■ Hepatitis-B antigen in whole 
blood, plasma and plasma fractions (human, monkeys) 
" POlHL-1559605 0020 Coagulation, fibrinolysis, 
hemostasis and hepatitis ■ Affinity chromatography 
P60HL-1 5996-06 0010 Cincinnati comprehensive sickle 
cell center - Whole blood viscosity in sickle cell anemia 
(human) 
P60HL-17265-04 0001 Community blood resource center 

support - Demonstration and evaluation 
ROIHL-19946-03 Reduction of iron overload in 
thalassemia (children, rabbits, dogs, monkeys) 
** ROlHL-20788-02 Preservation of human platelets for 
transfusion 
ROlHL-208 18-02 Platelet storage at 22 degrees C 

(human) 
P60HL-20985-01 0004 Northern California sickle cell 
center Characterization of irreversibly sickled cells 
(human) 
ROlHL-21791-01 Precipitation of proteins with poly 
(ethylene glycol) (human) 

BLOOD AND RE SYSTEM, BONE MARROW 

SEE ALSO BLOOD AND RE SYSTEM, HEMATOPOIHIC TISSUE 
SEE ALSO BLOOD CELLS, ERYTHROBUSTS AND ERYTHROIO 

STEM CELLS 
POlHL-1131012 0095 Mechanisms of cardiovascular 
disease - Blood and transfusion disorders (human, rats, 
monkeys) 
** P01HL18208-04 0003 Center for the study of blood cell 
rheology - Bone marrow microcirculation (rats, mice) 
P01HL18208-04 0005 Center for the study of blood cell 
rheology - RBC deformability and capillary flow 
interrelations (human, mice) 
ROlHL-19933-02 Membrane and red cell dysfunction in 

hemolytic anemia (human) 
ROlHL-20961-02 Hemoglobin Y-chain genes -Evolution and 

inducibility (monkeys, human) 
ROlHL-23736-04 Sickle cell anemia and hemoglobin 
synthesis (monkeys) 

BLOOD AND RE SYSTEM, BONE MARROW 
TRANSPLANTATION 

** NOlHB-6296303 International bone marrow transplant 

registry 
** NOIHB-62964-03 International bone marrow transplant 

registry 
POlHL-06314-17 0066 Immunologic mechanisms in 

cardiovascular disease - Sensitization, cell-mediated 

cytotoxicity, role of lymphocytes (human, mice) 
POlHL-13108-09 0016 Clinical heart transplantation ■ 

Total lymphoid irradiation for immune response (dogs) 
R01HL13987-04 Transplantation of the lung (dogs) 
ROlHL-15647-06 Hematopoietic studies of cyclic 

hematopoiesis (dogs) 
** ROlHL-16119-05 Spleen and marrow allografts in 

hereditary anemia (mice) 
P60HL-17265-04 0006 Community blood resource center 

support - Research-Evaluation of platelet transfusions 

(human, dog) 
P60HL17265-04 0008 Community blood resource center 

support - Research-Blood genetic markers as biological 

probes (human) 
ROlHL-19333-03 Hematopoietic chimerism (mice, monkey) 

BLOOD AND RE SYSTEM, HEMATOLOGY 

SEE ALSO BLOOD AND RE SYSTEM, BLOOD* 

SEE ALSO BLOOD AND RE SYSTEM. IMMUNOHEMATOLOGY 

(GENERAL) 
SEE ALSO BLOOD (HEMATOLOGIC) TESTS* 
SEE ALSO HEMATOLOGY STUDY SECTION 

(contd) 



•Excludes routint methodology OR covers only general proiecls which preclude indexing at the specific level 
**Oriented significantly to above subject 



M Grant has subprojects describing specific research aspects 
See Appendix for investigator's name and grant number. 



BIO 

POIHI 08899 14 0018 Toltttnci to («>pli«tory |ius in 

hMlth ind dijtis* Ettccts o( rfjplratoiy |is«i it 

titrtm* prtssuits (human) 
" ROIHI 10!>82 1? Thiombosij (nd hemostasis Analysis, 

methods and standards (human, cattla. venom) 
" POIHL 13738 08 0004 Caidiac assist devices and 

aititicial hearts Hematological evaluation a( prosthetic 

materials (calves) 
KOHL 16008 06 0009 Wayne State University 

comprahtnsive sickle cell center Natural history of sickle 

cell anemia (human) 
ROIHL I62M0S Pathogenesis ot bubble and clot 

toimation (lish) 
** POIHI 168SI 04 0010 Human ted cell membrane in 

health and disease Core facility Hematology clinic 
P60HL U26504 0010 Community blood resource center 

support Blood resources educational program 
" ROIHI 1740204 Mechanism ot contact activation ot 

intrinsic clotting (human) 
ROIHL 20106 02 Coupling ot platelet contractile proteins 

to librin (human) 
ROIHI 2078802 Preservation ot human platelets tor 

transfusion 
ROIHL 22603 01 Trace metals, vascular activity and 

hypertension (rats) 

BLOOD AND RE SYSTEM, HEMATOPOIESIS 

** ROIHL 15647-06 Hematopoietic studies of cyclic 

hematopoiesis (dogs) 
** P50HL- 1882803 0009 Specialized center ot research in 

thrombosis Platelet formation and megakaryocyte cell 

biology (guinea pig, human) 
** ROIHL 1933303 Hematopoietic chimensm (mice, monkey) 
ROlHL-2008602 Circulatory control of splenic function 

(rats) 
ROIHL 2090202 Studies on marginal band system of 

erythrocytes (amphibians, reptiles, fish) 

BLOOD AND RE SYSTEM, HEMATOPOIESIS, 
ERYTHROPOIESIS 

ROlHL-01601-30 Blood coagulation and hemorrhagic 
disease (horseshoe crabs) 
** ROlHL-03357-21 Humoral control of blood cell formation 

and release (rats, mice) 
•* ROlHL-04612-20 Feedback between red cell production 

and oxygen transport (rabbits, rats) 
*• R01HL07449-17 

(human) 
M P01HL-08899U 

and disease 
** ROlHL-1056712 Erythropoietin-Immunoassay and 
characterization (dogs) 
R01HL13237-09 Erythrocytes during early development 

(human, animals) 
ROlHL-15647-06 Hematopoietic studies of cyclic 
hematopoiesis (dogs) 
** P60HL15999-05 0019 Miami comprehensive sickle cell 
center ■ Fetal-adult hemoglobin switch (mouse, monkey) 
P60HL-1 5999-05 0021 Miami comprehensive sickle cell 
center ■ Diphosphonates-Eiythrocyte calcium loading, 
maturation (human, chick embryo) 
** P60HL-16005-05 0013 Comprehensive sickle cell center - 
Study of regulation of eiythropoiesis in vitro (human, rat, 
hamster, rabbit) 
** P60HL-16005-05 0022 Comprehensive sickle cell center ■ 
Regulation of erythropoiesis in patients with sickle cell 
anemia 
R01HL16580-04 Mathematical models for studying sickle- 
cell disease 
** R01HL16654-06 
(human) 
ROlHL-16675-05 
ROlHL-18186-04 



Formation and survival of red blood cells 
Tolerance to respiratory gases in health 



Regulation in developing erythroid cells 



Human urinary erythropoietin collection 
Cardiac allografts in autologous 

radiation chimeras (rats, dogs) 
ROlHL-19068-03 Changes in membrane properties during 

erythropoiesis (chick embryo) 
ROlHL-19270-03 Effects of erythropoiesis on platelets and 

hemostasis (rats) 
ROlHL-19933-02 Membrane and red cell dysfunction in 

hemolytic anemia (human) 
ROlHL-20300-02 Histone H5 and avian erythropoiesis 

(chickens, rabbits) 
ROlHL-20913-02 Cell culture studies of 

hemoglobinopathies (human) 
ROlHL-20922-02 Control of human fetal hemoglobin 

synthesis 
ROlHL-21683-02 Purification of erythropoietin (human) 
ROIHL-2170102 Purification of erythropoietin (human) 
** ROlHL-22650-01 Regulatory mechanisms of erythropoietin 

production (human, rats, mice) 
ROlHL-24048-01 Regulation of hemoglobin synthesis in 

chick embryos 

BLOOD AND RE SYSTEM, HEMATOPOIESIS, 
LEUKOPOIESIS 

** ROlHL-03357-21 Humoral control of blood cell formation 
and release (rats, mice) 
ROlHL-15647-06 Hematopoietic studies of cyclic 
hematopoiesis (dogs) 



4/ 



BLOOD AND RE SYSTEM, HEMATOPOIETIC 
FACTORS 

SI I ALSO BLOOD AND Rf SYSTEM, RE SIIMUIAIING 

FACTORS 
SEE Also HIOOD COAGUIAIION. IHROMBOPOIESIS 
STIMUIATINC FACIORS 
ROIHI 2019/ 02 Maintenance and repair of vascular 

endothelium (human, animals) 
ROIHI 21303 02 Collagen synthesis by cuMured human 
vasculai cells 

BLOOD AND RE SYSTEM, HEAAATOPOIETIC 
FACTORS, ERYTHROPOIETIC INHIBITORS 

ROIHI 21686 02 Purification of erythropoietin (human) 
BLOOD AND RE SYSTEM, HEMATOPOIETIC 
FACTORS, ERYTHROPOIETIN 

SEE ALSO VITAMIN B12 
*• NOIHB 82924 00 Source of human urinary erythropoietin 
** NOIHB 82926 00 Source ot human urinary erythropoietin 
ROIHL 03357 21 Humoral control of blood cell formation 
and release (rats, mice) 
** ROIHL 04612 20 Feedback between red cell production 
and oxygen transport (rabbits, rats) 
R01HL07449 17 Formation and survival of red blood cells 
(human) 
** ROIHL 10567 12 Erythropoietin- Immunoassay and 

characterization (dogs) 
** ROIHL 1088013 Purification of human erythropoietin (or 
research use 
ROIHL 14637-05 Thrombopoietin ■Immunoassay and 
characterization (mice) 
" P60HL-151 7005 0017 Support for center for sickle cell 
anemia - Control of hemoglobulin synthesis (human) 
R01HL15647-06 Hematopoietic studies of cyclic 
hematopoiesis (dogs) 
** ROlHL-1568505 Hemopoietic regulators produced in cell 
culture (human, animals) 
P60HL-16005-05 0013 Comprehensive sickle cell center • 
Study of regulation of erythropoiesis in vitro (human, rat, 
hamster, rabbit) 
" P60HL-1600505 0022 Comprehensive sickle cell center - 
Regulation of erythropoiesis in patients with sickle cell 
anemia 
** R01HL16675-05 Human urinary erythropoietin collection 
" POlHL-1820804 0003 Center for the study of blood cell 
rheology - Bone marrow microcirculation (rats, mice) 
ROlHL-2091202 Control on non-alpha chain synthesis in 

thassemic mice 
ROlHL-20961-02 Hemoglobin Y-chain genes-Evolution and 
Inducibility (monkeys, human) 
** ROlHL-21676-02 Purification and properties of 

erythropoietin (human) 
** ROlHL-21683-02 Purification of erythropoietin (human) 
** ROlHL-21686-02 Purification of erythropoietin (human) 
** ROlHL-21692-02 Purification of erythropoietin (human) 
** ROlHL-21701-02 Purification of erythropoietin (human) 
•* ROlHL-22650-01 Regulatory mechanisms of erythropoietin 
production (human, rats, mice) 

BLOOD AND RE SYSTEM, HEAAATOPOIETIC 
TISSUE 

SEE ALSO BLOOD AND RE SYSTEM, BONE MARROW 
SEE ALSO BLOOD AND RE SYSTEM, SPLEEN 
SEE ALSO BLOOD CELLS, HEMATOPOIETIC STEM CELLS 
(GENERAL) 
ROlHL-209 12-02 Control on non-alpha chain synthesis in 
thassemic mice 

BLOOD AND RE SYSTEM, 

IMMUNOHEMATOLOGY (GENERAL) 

ROlHL-022 54-23 Blood coagulation and hemorrhagic 

disease (human, animals) 
ROlHL-03424-21 Formation and properties of prothrombin 

derivatives (human, animals) 
ROlHL-07652-14 Destruction of red blood cells in 

hemolytic anemias (human, guinea pigs) 
R01HL08399-15 Platelet injury in infections and allergic 

diseases (human) 
** ROlHL-10036-13 Biology of red cell antigen-antibody 

reaction (human) 
ROlHL-1056712 Erythropoietin-Immunoassay and 

characterization (dogs) 
ROlHL-11154-12 Blood group antigens and antibodies 

(human) 
P01HL11310-12 0095 Mechanisms of cardiovascular 

disease - Blood and transfusion disorders (human, rats, 

monkeys) 
R01HL-n686-09 Dynamics of thrombus formation and 

dissolution (human, chickens) 
** R01HL1299409 The Rh complex of red cells (human) 
R01HL13336-09 Biochemistry and physiology of human 

platelets 
** ROlHL-13585-05 Heterogeneity of NADH methemoglobin 

reductase (human) 
ROlHL-13629-08 Hemorrhagic diseases (human) 
P60HL-1 51 58-07 0020 Comprehensive sickle cell center - 

Immunochemical investigation of hemoglobin variants 

(human) 
ROlHL-15690-07 Hydrolytic enzymes of blood in health 

and disease (human, animals) 
** ROlHL-16626-05 Studies of antibodies to antihemophilic 

factors (human, rabbits) 



NO I HI M,b4bO'i 

(human) 
ROIHI 16/20 02 
ROIHL 16/5/04 
ROIHI 168/2 04 



BLO 



Paltiotiiolrjiy uf \hiun\ln9mUo\ii. dllo(d«fl 



Pliteitt i|ir«|ali«n (human) 
Autoimmune Ihrombocytopania (monkty) 
Antihemophilii liilor (human) 
P60H1 1/265 04 0003 Community blood r««ourca c«nt(( 

support Research Human factor IX Role in tntriniic 
clotting (al^o baboons dogs) 
P60HI 1/265 04 0006 Community blood resource canter 

support Research Evaluation of platelet tiansfutioni 
(human, dog) 
ROIHI 1//52 03 Purified human clotting laclor IX 

Immunologic studies (human) 
ROIHL 18012 04 Cellular delects in nocturnal 

hemoglobinuria (human) 
ROIHI 18186 04 Cardiac allografts in autologous 

radiation chimeras (rats, dogs) 
ROIHI 1885903 Brochemlstry of human factor XI (human) 
ROIHL 18935 03 '' '■nen. soluble fibrin 

interaction (humoni 
ROIHL 1910502 Detection and adherence of fibrin 
monomer complexes (human) 
** ROIHL 19646 03 An immunologic study of hemoglobin 

variation in man 
•• ROIHL 1976/ 01 Palhochemistry of fibrinogen (humans) 
** ROIHL 20014 02 Radioimmunoassay of hyper and 
hypocoagulable states (rabbits) 
ROIHL 20314 02 Host defense against S pheumoniae in 

sickle cell disease (human) 
P60HL 20985 01 0007 Northern California sickle cell 
center Immunohemalologic abnormalities in sickle cell 
anemia (human) 
R23HL 2120802 Structure function relationships of human 

factor VIII 
ROlHL-2137901 Structure of factor VIII Von Willebrand 

protein (human) 
ROlHL-2140302 Blood clotting kinetics studied by 
radioimmunoassay (human) 
** ROlHL-2143102 Factor II antigen and coagulant activity 

(human, animals) 
** ROlHL-2 1543-02 Structure-function relation of blood 
clotting proteins (rabbits) 
R23HL-21730-01 vWagll A new vWD deficient antigen 

(human) 
ROlHL-21975-01 Studies on normal and abnormal factor 
IX (human, dogs, cows) 
** ROlHL-22355-01 Purification, structure and function of 
factor VIII (human) 
ROlHL-22505-01 Molecular pathology of fibrinogen and 

factor XIII (human, animals) 
ROlHL-22671-01 Removal of senescent and stored human 

red cells 
R23HL-22799-01 Interaction of the complement and 

coagulation systems (monkeys) 
ROlHL-23654-01 Selected topics on blood transfusion 
(rabbits, human) 

BLOOD AND RE SYSTEM, LYMPH 

** ROlHL-03180-21 Relation of lymphatics to 

cardiopulmonary function (dogs) 
ROlHL-10940-13 Lipid transport (rabbits, cattle, chickens) 
P01HL11678-11 0070 Cardiovascular dynamics and their 

control - Interaction of the four Starling forces (dogs) 
" ROlHL-13341-06 Lymph -An indication of splanchnic tissue 

respiration (dogs, human, rats) 
P50HL-14164-07 0033 A/S SCOR-Comparative and 

experimental atherosclerosis - Comparative studies of 

lipoprotein distribution and metabolism (monkeys) 
P50HL14164-07 0037 A/S SCOR-Comparative and 

experimental atherosclerosis - Genetic control of plasma 

cholesterol-Interaction of dietary fatty acid (monkey) 
** ROlHL-17781-03 Hypertension, kidney disease and renal 

lymph (dogs, rats) 

BLOOD AND RE SYSTEM, LYMPH FLOW 

ROlHL-04512-19 Ultrastructural studies of capillary 

permeability (rats, mice) 
POlHL-08899-14 0025 Tolerance to respiratory gases in 

health and disease - Effects of oxygen on cardiopulmonary 

gas transport functions (dogs) 
" POlHL-11678 11 0035 Cardiovascular dynamics and their 

control - Lymph flow rate and protein concentration (dogs) 
POlHL-11678-11 0036 Cardiovascular dynamics and their 

control - Pulmonary capillary dynamics and edema (dogs) 
POlHL-11678-11 0039 Cardiovascular dynamics and their 

control - Capillary and interstitial fluid dynamics of the 

intestine (cats) 
R01HL16916-04 0001 The role of albumins in lung water 

accumulation - Capillary permeability (dogs, human) 
** R01HL18010-04 Capillary transport ot large molecules 

(dogs, sheep) 
M P50HL-19153-02 

pathogenesis 
P50HL 19153-02 0001 SCOR-Pulmonary edemas-Eitology, 

pathogenesis • Prostaglandins and the lung circulation 

(sheep) 
P50HL19153-02 0002 SCOR-Pulmonary edemas-Eitology, 

pathogenesis - Lung fluid dynamics-Classical mediators 

and their inhibitors (sheep) 
P50HL19153-02 0003 SCOR-Pulmonary edemas-Eitology, 

pathogenesis - Possible inhibitors of mediator release and 

pulmonary vascular response (sheep) 

(contd) 



SCOR-Pulmonary edemas-Eitology, 



*Ewludes routine melhodok>gy OR cavers only general proiects which preclude indexing at the specific level. 
"Oriented significantly to above subject. 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigator's name and grant number 



BLO 



48 



BLO 



" P50HL-19153-02 0004 SCOR-Pulmonaiy edemas-Eitology, 
pathogenesis Physical mechanisms In lung transvascular 
transport -Math models (sheep) 
P50HL19153-02 0007 SCOR-Pulmonaty edemas-Eitology, 

pathogenesis - Core-Experimental laboratories and support 
facilities 
** R01HL19370-03 Coronary capillary exchange-The effects 
of ischemia (dogs, sheep) 
POlHL-20994-02 0001 Dynamics of neutrophil elastase in 
the lung • Dynamics of neutrophil elastase in normal 
animals (dogs, rabbits) 
ROlHL-21076-02 Lung fluid, protein exchange after 

hemorrhagic shock (sheep) 
ROlHL-21452-02 Pulmonary capillary filtration in 

myocardial ishemia (dogs) 
ROlHL-2149802 Pathophysiology of edema (rats, cats) 
ROlHL-21948-01 Capillary, tissue volume and lymph flow 

in lung edema (sheep, cattle) 
ROlHL-22520-01 Pulmonary vascular response to group B 
Streptococci (human, mammals) 
** R01HL-22549-02 Transport across alveolar capillary 
membrane (dogs) 
POlHL-22602-01 0002 Pathophysiology of the 

endothelium - Molecular charge and endothelial 
permeability (rats, mice) 
** ROlHL-22911-01 Mechanism of clearance of lung edema 

fluid (dogs) 
** R23HL-22933-01 Transvascular fluid and protein exchange 
in the lung (sheep) 

BIOOO AND RE SYSTEM, LYMPHATIC 
CIRCULATION (GENERAL) 

** ROlHL-03180-21 Relation of lymphatics to 

cardiopulmonary function (dogs) 
ROIHL 12493-10 Bioengineering analysis of microvascular 

function (cats, rabbits) 
R01HH3341-06 Lymph -An indication of splanchnic tissue 

respiration (dogs, human, rats) 
** ROlHL-1390108 Ontogeny, ultrastructure, function in 

lymphatic system (birds, fish, mammals) 
ROlHL-1615405 Membrane lung perfusion for acute 

respiratory failure (sheep, baboons) 
ROlHL-17596-03 Leukocyte-endothelial interactions (rats) 
P50HL-1764604 0005 Study of ischemic heart disease - 

Biochemical markers and mediators of myocardial ischemic 

injury 
P50HL-1915502 0004 Pathophysiology of pulmonary 

edema - Physical and chemical effects of multiple 

pulmonary emboli (sheep) 
** P50HL19155-02 0005 Pathophysiology of pulmonary 

edema - Protein exchange sites and lymph protein 

concentration in lung (mice, sheep) 
P50HL19185-02 0004 Pulmonary SCOR-Neonatal 

respiratory distress syndromes - Fluid and protein transport 

in fetal and newborn lung (sheep, rabbits) 

BLOOD AND RE SYSTEM, LYMPHATIC 
CIRCULATION, THORACIC DUCT 

R01HL13341-06 Lymph-An indication of splanchnic tissue 
respiration (dogs, human, rats) 

BLOOD AND RE SYSTEM, LYMPHATIC DUCT 
DRAINAGE 

POlHL-06285-18 0145 Cardiovascular-respiratory 

physiology and biochemistry - Pulmonary, pleural and 

systemic microcirculation (animals) 
** POlHL-06312-17 0029 Surgical cardiology - Cardiac 

lymphatics in the transplanted heart (dogs) 
ROlHL-1317210 Post-trauma lung mechanics and fluid 

exchange (human, dogs, monkeys) 
ROlHL-23211-01 Active normoxic pulmonary vasodilatation 

(rat. dog, sheep) 

BLOOD AND RE SYSTEM, LYMPHATIC TISSUE 

SEE ALSO BLOOD AND RE SYSTEM, SPLEEN 
** POlHL-13 108-09 0016 Clinical heart transplantation ■ 

Total lymphoid irradiation for immune response (dogs) 
" POlHL-16769-05 0010 Pathobiologic and host defense 
reactions in the lung - Bronchus associated lymphoid 
tissue and delayed hypersensitivity (rabbits) 
ROlHL-19741-03 Murine CRD -A model of chronic 

pulmonary inflammation (mice, rats) 
ROlHL-19760-01 Cellular immune responses of the lung 

(mice, guinea pigs) 
ROlHL-22924-01 The airway mucosal barrier (guinea pigs) 

BLOOD AND RE SYSTEM, LYMPHATIC TISSUE, 
LYMPH NODES 

** R01HL08696-15 0010 Orthotopic heart transplantation - 
Transplantation immunology-Total lymphoid irradiation 
(dogs, primates) 
P01HL16769-05 0003 Pathobiologic and host defense 
reactions in the lung • Pathobiologic mechanisms of 
delayed sensitivity reactions in the lung (animals) 
R01HL17596-03 Leukocyte-endothelial interactions (rats) 
ROlHL-20954-02 Hyperlipoproteinemia (rats, human) 

BLOOD AND RE SYSTEM, MACROPHAGES 

SEE ALSO LIVER CELLS, KUPFFER CELLS 
SEE ALSO RESPIRATORY SYSTEM, ALVEOLAR MACROPHAGES 
P01HL-03174-23 0005 Mechanisms of acute vascular 

reaction to injury - Renal small vessel didease -Cell and 

matrix response (human, mice) 



POlHL-063 14-17 0046 

cardiovascular disease 

(human, mice) 
POlHL-063 14-17 0048 

cardiovascular disease 

(rats, mice) 
POlHL-063 14-17 0052 

cardiovascular disease 



Immunologic mechanisms in 
Mediators of immune injury 

Immunologic mechanisms in 
Pathogenesis of glomerulonephritis 



Immunologic mechanisms in 
Role of cyclic nucleotides in 

neutrophil function (human) 
POlHL-063 14-17 0064 Immunologic mechanisms in 

cardiovascular disease - Diabetic vascular disease (human, 

rats, mice) 
** POlHL-06314-17 0066 Immunologic mechanisms in 

cardiovascular disease - Sensitization, cell-mediated 

cytotoxicity, role of lymphocytes (human, mice) 
POlHL-06314-17 0067 Immunologic mechanisms In 

cardiovascular disease - Mitogenic and antigenic activation 

of lymphocyte sub-populations 
ROlHL-07652-14 Destruction of red blood cells in 

hemolytic anemias (human, guinea pigs) 
POlHL-08682-15 0019 Regulation of the cardiovascular 

system - Hepatic immunophysiology and host-defense in 

shock (rat, dog, human) 
POlHL-08682-15 0020 Regulation of the cardiovascular 

system - Hepatic metabolic basis of shock (rat) 
ROlHL-12839-09 Flow, transport and membrane 

phenomena in blood (human) 
P50HL-14147-08 0006 Specialized center of research in 

thrombosis - Clearance mechanisms of coagulation 

moieties (human, rabbits, rodents) 
P50HL-141 53-07 0004 Johns Hopkins Lung Center- 
Chronic diseases of airways - Macrophage enzymes in lung 

injury, inflammation and repair (rabbit) 
P50HL-15061-07 0009 Response of lung to injury - 

Alveolar macrophages (human, rabbits) 
P60HL-15999-05 0008 Miami comprehensive sickle cell 

center - Cyanate effect on host defense -Cellular and 

humoral (human, guinea pig. rabbits) 
POlHL-174 17-05 0003 Experimental lung transplantation 

- Methods for detecting lung allograft rejection (dogs) 
P01HL18827-02 0006 Platelet vessel wall interactions in 

thrombogenesis - Platelet immune injury in man 
ROIHL- 190 10-03 Metabolism and cell biology of lung 

surfactant system (rabbits, sheep) 
P50HL-191 71-02 0007 Pulmonary SCOR-Lung injury by 

childhood infections - Immunologic studies in models of 

lower respiratory tract infection (rodents) 
ROlHL-194 19-03 Cellular interactions with foreign 

materials (mammals) 
ROlHL-19628-03 Mechanisms of pulmonary alveolar 

proteinoses (human, rats) 
** R01HL19732-03 Lymphokines in pulmonary 

granulomatous inflammation (mice) 
ROlHL-19774-03 Pathogenesis of chronic lung disease 

(rats, mice, bacteria) 
ROlHL-19779-03 Biochemical basis of oxygen damage to 

lung cells (guinea pigs, rats) 
ROlHL-20104-03 Pulmonary granulomatous inflammations 

(mice) 
ROlHL-21047-01 Studies of coxsackievirus-induced 

myocarditis in mice 
R23HL-21 134-02 Immune function and fibrogenesis in 

silicosis (guinea pigs) 
ROlHL-21156-02 Antitrypsin and other causes of chronic 

lung disease 
** R23HL-212 12-02 Alveolar macrophage function in 

Pseudomonas infection (dgs) 
R23HL-21805-01 Tissue cell interactions with vascular 

prostheses (human, rats, mice) 
ROlHL-22456-01 Lipoproteins in bioregulation of the 

immune response (mice, human) 
" ROlHL-22474-01 Cholesterol metabolism and 

atherosclerosis (rats, human, rabbits) 
ROlHL-2255501 Structure and function of platelet 

activating factor (rabbits, human) 
** ROlHL-22671-01 Removal of senescent and stored human 

red cells 
ROlHL-22739-01 

atherosclerosis 
ROlHL-23654-01 

(rabbits, human) 

BLOOD AND RE SYSTEM, MAST CELLS 

ROlHL-02953-17 Autonomic and cardiovascular 
pharmacology (rats, rabbits, dogs, guinea pigs) 
** POlHL-031 74-23 0009 Mechanisms of acute vascular 
reaction to injury - Mast cell lipid interaction (human, rats) 
POlHL-0789615 0043 Environmental biomedical research 
program - Effect of hyperbaric oxygen on the lung (human, 
rabbits) 
P50HL-141 53-07 0015 Johns Hopkins Lung Center- 

Chronic diseases of airways ■ Kinins and human lung 
** POlHL-14985-07 0010 Adaptation to hypoxia - Pulmonary 

mast cell (animals) 
** POlHL-164 11-04 0001 Blood systems in coagulation and 
vessel disease - Molecular studies of the role of 
complement in blood coagulation (human, rabbits) 
POIHL- 178 13-04 0001 Lung disease and the oxygenation 
of blood and tissue - Diffuse interstitial lung disease- 
Pathophysiology (human, dogs) 
** ROlHL-1906203 Pharmacologic control of mast cell 
phosphodiesterase (human, rats) 



Evolution and progression of pediatric 
Selected topics on blood transfusion 



** P50HL-19156-02 0004 Pulmonary SCOR-Chronic diseases 

of airways - Interactions between mast cells, mediators 

and nerves in canine asthma 
ROlHL-19777-03 Regulation of hypersensitivity in the lung 

(rats, guinea pigs, rabbits, human) 
** R23HL-21089-02 Localization of mediators in dispersed 

lung cells (guinea pigs, human) 
R01HL-215e5-02 Pathogenesis of inflammatory lung injury 

(rats, rabbits) 
R23HL-22011-01 Adrenergic receptor cyclase system in 

sensitized lung (rats, guinea pigs) 
ROlHL-22402-01 Heparin-biophysical, chemical and 

biological aspects (mice, human) 
ROlHL-23209-01 Autonomic receptors of the pulmonary 

vasculature (mammals) 
** ROlHL-23593-01 Mast cell granules-Structure and 

secretion (rats) 

BLOOD AND RE SYSTEM, MEGAKARYOCYTES 

ROlHL-13336-09 Biochemistry and physiology of human 

platelets 
R01HL14637-05 Thrombopoietin-lmmunoassay and 
characterization (mice) 
** POlHL-18208-04 0003 Center for the study of blood cell 

rheology - Bone marrow microcirculation (rats, mice) 
ROlHL-18714-04 Cardiovascular matrix-Morphogenesis 

and maturation (human, chick embryo, mammal) 
P50HL 18828-03 0001 Specialized center of research in 
thrombosis Membrane biology and hemostasis (human) 
P50HL-18828-03 0005 Specialized center of research in 
thrombosis - Platelet inflammatory factors in thrombosis 
(human, guinea pig) 
** P50HL-18828-03 0009 Specialized center of research in 
thrombosis - Platelet formation and megakaryocyte cell 
biology (guinea pig. human) 
ROlHL-19270-03 Effects of erythropoiesis on platelets and 
hemostasis (rats) 
** R01HL-2082e-02 Megakaryocyte proliferation and its 

control (mice) 
** POlHL-22633-01 0003 Cellular and molecular biology of 
lipoprotein metabolism Sterol metabolism in platelets and 
megakaryocytes (human, rabbits, guinea pigs) 

BLOOD AND RE SYSTEM, RE STIMULATING 
FACTORS 

SEE ALSO BLOOD AND RE SYSTEM, HEMATOPOIETIC FACTORS 
" ROlHL-1800203 Circulatory shock, trauma and RE-system 
function (rats) 

BLOOD AND RE SYSTEM, RETICULOENDOTHELIAL 
SYSTEM (GENERAL) 

POlHL-08682-15 0019 Regulation of the cardiovascular 

system - Hepatic immunophysiology and host-defense in 

shock (rat, dog, human) 
POlHL-08682-15 0020 Regulation of the cardiovascular 

system Hepatic metabolic basis of shock (rat) 
** POlHL-08682-15 0021 Regulation of the cardiovascular 

system Hypoglycemia in pathogenesis of shock (dog) 
R01HL18284-04 Aging erythrocytes-Bio-recognitlon and 

elimination (monkeys) 
** ROlHL-18731-02 RES stimulating materials in 

experimental shock (dogs) 
R23HL-21271-02 Extracorporeal circulation and protein 

denaturation (human) 
ROlHL-22470-01 Liposome myocardial uptake in infarct 

and ischemia (dogs, rats, mice) 

BLOOD AND RE SYSTEM, SPLEEN 

SEE ALSO BLOOD AND RE DISORDERS, SPLENIC DISORDERS 
ROlHL-07723-15 Reflex control of vascular capacitance in 

shock 
POIHL- 16 748-05 0006 Cellular and immunological basis 

of pulmonary diseases - Sarcoidosis -Studies with bronchial 

lavage (human) 
ROlHL-18096-04 Vasoactive agents in splanchnic viscera 

(primates, dogs) 
POlHL-18208-04 0003 Center for the study of blood cell 

rheology - Bone marrow microcirculation (rats, mice) 
** POlHL-18208-04 0004 Center for the study of blood cell 

rheology - Splenic microcirculation (rats, mice) 
ROlHL-18995-04 Cardiovascular determinants of 

catecholamine release (dogs) 
** ROIHL-20086-02 Circulatory control of splenic function 

(rats) 
ROlHL-20787-02 Thromboxanes and prostaglandins- 

Biochemical pharmacology (rabbits, human) 
ROlHL-21159-02 Pathophysiological effects of hypoxia 

(rats) 
ROlHL-22367-01 Estrogen receptors in very low density 

lipoproteins (chicken livers) 

BLOOD AND RE SYSTEM, SPLEEN TISSUE (CELLS) 
TRANSPLANTATION 

** R01HL-16119-05 Spleen and marrow allografts in 
hereditary anemia (mice) 
ROlHL-20086-02 Circulatory control of splenic function 

(rats) 
ROlHL-20170-02 Pulmonary infection in splenectomized 
animals (mice) 

BLOOD AND RE SYSTEM, SPLENECTOMY 

ROlHL-13341-06 Lymph-An indication of splanchnic tissue 

respiration (dogs, human, rats) 
ROlHL-16757-04 Autoimmune' thrombocytopenia (monkey) 

(contd) 



'Excludes routine methodokigy OR covers only general projects which preclude indexing at the specific level. 
"Oriented sicnificantty to above subject. 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



BLO 



49 



BIO 



Biochemistry and physiology of human 



RUIHl 1899/02 Ischemic thetipy In uptrlmantil 

hypecipUnlsni (ids. dogs) 
ROIHl 19760 01 Cellulai imnuing lesponsts ol tht luni 

(mica, guinaa pigs) 
ROIHL 20086 02 Clrculaloty contiol ol splanic lunclion 

(rats) 
" ROIHL 2U WO 02 PulmonaiY intection in splenactomijod 

animals (mica) 
P60HI 23282 01 0002 Compiehensive huspital/community 

sickle cell cental Clinical ev.iluatian ol alleinate 

pathaway ol compliment activation 

BLOOD AND RE SYSTEM, THYMECTOMY 

KOIHL 16246 06 Immunologic studios in 

postpericaidiotomy syndrome (human) 
ROIHL 22301 01 Immunogenetics ol chronic pulmonaiy 

intlammation (mice) 

BLOOD AND RE SYSTEM, THYMOSIN 

P60HL'1600806 0019 Wayne State Univeisily 
comprehensive sickle cell centei Cell mediated immunity 
in sickle cell anemia (human) 

ROIHL 19/74 03 Pathogenesis of chronic lung disease 
(rats. mice, bacteria) 

BLOOD AND RE SYSTEM EXAMINATIONS 

StE BLOOD AND RE DISORDERS DIAGNOSIS (INCL EXAMS)* 

BLOOD AND RE SYSTEM PHARMACOLOGY 

SEE ALSO BLOOO AND RE DISORDERS CHEMOTHERAPY 
NOIHB'22922 08 Develop etfective therapy lor sickle cell 

disease (human, dogs) 
POIHL 04664 18 0008 Cardiovascular and lung dynamics 

■ Micrographic video imaging technique 
R01HL09163 13 Control mechanisms in hemostasis 

(human) 
** ROlHL-0973913 Biophysical studies of proteins (human) 
ROIHL 10383 12 Physical chemical studies of hemoglobins 

and erythrocyte (human) 
ROIHL 1225615 Polymerization of sickle-cell hemoglobin 

(human) 
R01HL1333609 

platelets 
R01HL-13466-08 Pulmonary platelets in shock, trauma 

and embolization (dogs. pigs, rats) 
** P50HL1421708 0057 Specialized center of research in 

thrombosis - Pharmacology-Platelet biochemistry (human, 

animal) 
** P50HL-14217 08 0061 Specialized center of research in 

thrombosis - Pharmacology-Comparison of platelets and 

vascular smooth muscle (animal) 
ROlHL-14739-06 The role of leukocytes in thrombotic 

disease (human, dogs) 
P60HL1515707 0009 Comprehensive center for sickle 

cell disease - Red cell membrane alterations during 

sickling (human) 
P60HL-15157-07 0011 Comprehensive center for sickle 

cell disease - Development of specific anti-sickling 

compound (human) 
P60HL-15158-07 0011 Comprehensive sickle cell center - 

Clinical services-Adult patients 
P60HL15162-07 0019 Comprehensive sickle cell center - 

RBC-Blood rheology in sickle cell anemia and related 

disorders (human, animal) 
P60HL-1516807 0009 Comprehensive sickle cell disease 

center - Spin-label study of sickling (human) 
** ROlHL-15293-07 Sickle cell hemoglobin-Interactions and 

aggregation (human) 
ROlHL-15668-06 Extracorporeal respiratory gas exchange- 

A new approach (dogs) 
*• P60HL1 5999-05 0021 Miami comprehensive sickle cell 

center - Diphosphonates-Erythrocyte calcium loading, 

maturation (human, chick embryo) 
POlHL-16387-04 0005 The blood vessel and 

thrombogenesis - Fluid engineering considerations in 

thrombogenesis 
ROlHL-16582-05 
R01HL-I6647-05 

(human) 
POlHL-16833-04 0009 

hemoglobinopathies 

(human) 
POlHL-16833-04 0017 

hemoglobinopathies 

effect (human) 
P60HL-1 7265-04 0003 Community blood resource center 

support - Research-Human factor IX-Role in intrinsic 

clotting (also baboons, dogs) 
ROlHL-1 7479-04 Blood storage -The production of 

cardiotoxic material (dogs, human, swine) 
R01HL-17571-03 Study of membrane permeability by NMR 

relaxation (human) 
ROlHL-17596-03 Leukocyte-endothelial interactions (rats) 
ROlHL-17747-04 Endothelial injury and regeneration (rats) 
POlHL-17812-04 0004 Thrombosis and plasma proteins - 

Serum-platelet interaction (human) 
POIHL-17812-04 0005 Thrombosis and plasma proteins - 

In vitro systems of normal platelets, white cells, sera 

(human) 
ROlHL-1793003 Platelet membrane function-Assessment 

and application (animals) 
ROlHL-18002-03 Circulatory shock, trauma and RE-system 

function (rats) 



Artificial lungs (dogs) 

Studies on the control of sickle cell crisis 

Hemoglobin and red cell system in 
Rheological studies of sickled cells 

Hemoglobin and red cell system in 
Sulfhydryl group blockade antisickling 



POIHI 18208 04 UDOS Cenlei tor the kludy ol bliiud mil 

rheology RH(' deloiiiiiibility and capillary How 

intorielnlluns (human, micel 
POIMI l8S/6 0:i onni llirumbosis research program 

pinicrt Phitrli't d.image liom physical forces and 

ditiliiial surfiiies (humnn) 
POIHL 185/6 0:1 000/ Ihrombosis research program 

project Relationships between coagulability and 

thrombosis (human, animals) 
POIHL 185/6 03 0012 Thrombosis research program 

protect Synthetic anticoagulant and thrombolytic agents 

(dogs) 
ROIHL 1864403 Prosthesis lor aortocoronary bypass 

(dogs, baboons) 
ROIHL 18660 03 Neurotransmitter receptors in human 

erythrocytes 
POIHL 18827 02 0006 Platelet vessel wall interactions in 

thrombogenesis Platelet immune injury in man 
P50HL 18828 03 0004 Specialized centei ol research in 

thrombosis Membrane changes in platelet physiology Role 

of complement (mice, human) 
P50HL 18828 03 0005 Specialized center of research in 

Ihrombosis Platelet inflammatory factors in thrombosis 

(human, guinea pig) 
P50HL 18828 03 0008 Specialized center of research in 

thrombosis Biochemistry, physiology Platelets and 

subcellular platelet particles (human) 
P50HL 18828 03 0009 Specialized center of research in 

thrombosis Platelet lormation and megakaryocyte cell 

biology (guinea pig, human) 
ROIHL 1909503 Laser spectroscopy of lipoproteins 

(human) 
** R01HL1953201 
R01HL-20319 02 

fibrin (human) 
** P60HL-20985 01 0006 Northern California sickle cell 

center - Antisickling properties of imidoesters (human, rats) 
POlHL-21016-02 0010 Sickle cell anemia and other 

hemoglobinopathies Alkylureas as potential antisickling 

agents 
R23HL-2 11 29-02 The antisickling effects of imidoesters 
R23HL-214 13-02 Structure and function of platelet 

calcium-binding protein (human) 
** ROlHL-22035 01 Molecular modification of heparin by 

chemical means (sheep) 
POlHL-22163-01 0003 Surface thrombogenesis - 

Mechanisms and prevention - In vivo mechanisms of 

biomaterial thrombogenesis and its prevention (baboons) 
ROlHL-221 94-02 Allosteric function of platelet contractile 

proteins (human) 
ROlHL-22607-01 Role of apolipoprolein E in lipoprotein 

metabolism (human) 

BLOOD BACTERICIDAL ACTIVITY (GENERAL) 

SEE IMMUNITY, BACTERICIDAL DEFENSES (GENERAL) 

BLOOD BANKS 

SEE BLOOD PRESERVATION, BLOOD BANKS, CENTERS- 
RESOURCES-REGISTRIES 

BLOOD-BRAIN BARRIER 

SEE CEREBROVASCUUR SYSTEM, 



Oxygen toxicity in the red cell (human) 
Assembly, structure and interactions of 



BLOOD-BRAIN BARRIER 



BLOOD CELL COUNT 

SEE BLOOO (HEMATOLOGIC) TESTS, BLOOD CELL COUNT- 
BLOOD CELL DEPLETION THERAPY, LYMPHOCYTE 
DEPLETION 

SEE ALSO BLOOD AND RE SYSTEM, LYMPHATIC DUCT 
DRAINAGE 
ROlHL-14799-07 Cardiac heterotransplantation- 
Immunologic modification (mice, rat) 

BLOOD CELL DEPLETION THERAPY, T 
LYMPHOCYTE DEPLETION 

ROlHL-08696-15 0010 Orthotopic heart transplantation - 
Transplantation immunology-Total lymphoid irradiation 
(dogs, primates) 

BLOOD CELL FORMATION 

SEE BLOOD AND RE SYSTEM. HEMATOPOIESIS 

BLOOD CELLS 

** ROlHL-12944-09 Enzymatic and biochemical studies on 

blood cells (human) 
** POlHL-16851-04 0009 Human red cell membrane in 

health and disease - Blood cell properties in circulatory 

regulation (dogs, rabbits) 
** POlHL-16851-04 0012 Human red cell membrane in 

health and disease - Computer unit-Core facility 

BLOOD CELLS, ERYTHROBLASTS AND ERYTHROID 
STEM CELLS 

SEE ALSO BLOOD AND RE DISORDERS. ANEMIA 
SIDEROBLASTIC 
ROlHL-046 12-20 Feedback between red cell production 

and oxygen transport (rabbits, rats) 
P60HL-I5999-05 0019 Miami comprehensive sickle cell 

center - Fetal-adult hemoglobin switch (mouse, monkey) 
ROlHL-20300-02 Histone H5 and avian erythropoiesis 
(chickens, rabbits) 
*♦ ROlHL-20899-02 Cellular mechanisms of hemoglobin F 
regulation (human) 
ROlHL-20905-02 Synthesis of fetal hemoglobin in erythroid 
cells (sheep, human) 



*Excludet routine methodology OR covers only general projects which preclude indexing 
••Onented significantly to above subject. 



BLOOD CELLS, ERYTHROCYTES 

Ml AI'.U IIIIKiD AND hi iJl'.UNDI N'.. ANI MIA 

SI I Al',>0 BIOUD AND Ri DI'.UROI K;.. UONi MARROW 

POIYIYIHIMIA 
SEE ALSO fiLOUb AND Rl '.y:,I(M. HrMAIOPOIF^S. 

fRYIIlROCOIIM', 
Stf AISOBIOOD IRIAtMFNI I'lA'.MAI'IIIRISIS 
SEE Also HIMUPROIIIN',. Ml M(JOI UIIINOPATHIES 
SEI AISOMfMHRANf IRYIIIROCYIE UHOSI AND 

MIMIIKANf 
SE! ALSO PROILINS. MEMBRANE PROTEINS. SPECTRIN 
" NOIHB 62962 02 Red cell diilributioni in cyanilf-traaled 
blood (human, sheep) 
POIHI 03174 23 0000 Mechanisms of acute vatcular 

reaction to injury Atherosclerotic plaque sludiei using 
mosaic analysis (human) 
POIHL 03174 23 0010 Mechanisms of acute vascular 

leaction to injury Search lot mutagens in the human 
blood (bacteria, animals) 
POIHI 06835 1/ 0019 Cardiovascular disease Fatty 

acid distribution (rats) 
•• RaiHL06950 17 Red cell metabolism (human, 

vertebrates) 
" R01HL07449 1/ Formation and survival of red blood cells 
(human) 
POIHL 09011 15 0001 A research and resource program 

in blood Genetic markers of human blood and gene 
mapping (human) 
" ROIHL 09906 13 0019 Membrane transport processes in 

red blood cells Hemoglobin change and membrane 
potentials in red blood cells at varying volumes 
" ROIHL 09906 13 0020 Membrane transport processes in 

red blood cells - Calibration of a fluorescent probe for 
erythrocytes 
** ROlHL-09906 13 0021 Membrane transport processes in 

red blood cells Membrane potentials in human red blood 
cells due to proton gradients 
" ROIHL 09906-13 0022 Membrane transport processes in 

red blood cells Anion transport in dog and cat red cells 
** ROIHL 09906 13 0023 Membrane transport processes in 

red blood cells Cation and anion movements in two sub 
groups of dog erythrocytes 
** ROIHL 09906 13 0024 Membrane transport processes in 

red blood cells - Inhibition of sulfate transport in human 
RBCs by isothiocyanic acid esters 
** ROlHL-09906 13 0025 Membrane transport processes in 

red blood cells - Mechanism of propranolol induced Ca- 
dependent K efflux from human RBCs 
** ROIHL 10036-13 Biology of red cell antigen-antibody 

reaction (human) 
** ROIHL 10383-12 Physical-chemical studies of hemoglobins 
and erythrocyte (human) 
ROlHL-11152-12 Vascular physiology (human, cats, dogs) 
R01HL-U901-12 0017 Effects of metabolic surgery on 

the hyperlipidemias - Membrane permeability, blood 
viscosity, oxygen uptake-Rheology studies (rabbits) 
ROlHL-12684-09 Angiotensin I and converting enzyme in 
hypertension (human, primates, dogs) 
** ROlHL-12972-09 Glutathione deficiency in red cells 

(sheep, dogs) 
** POlHL-13108-09 0012 Clinical heart transplantation • 

Human T cell sheep erythrocyte receptors 
** ROlHL-13237-09 Erythrocytes during early development 
(human, animals) 
ROlHL-13585-05 Heterogeneity of NADH methemoglobin 

reductase (human) 
POlHL-13737-07 0026 Assisted circulation • Hemostatic 

mechanism (human, dogs) 
ROlHL-14127-16 Methemoglobinemia and antihypertensive 

drugs (cats, mice, rats) 
P50HL-14217-08 0050 Specialized center of research in 

thrombosis - Electron microscopy section (dogs) 
P50HL-14230-07 0093 A/S SCOR-Lipids, atherosclerosis 

and thrombosis Clinical studies involving cellular lipid 
content (human) 
POlHL-14414-07 0014 Environmental influences on 

cardiorespiratory and cellular functions - Temperature and 
acid-base status in tissues, cells, and subcellular system 
POlHL-14985-07 0011 Adaptation to hypoxia - 

Prostaglandins in the control of the pulmonary circulation 
(animals) 
POlHL-14985-07 0012 Adaptation to hypoxia - Direct 

effect of hypoxia on pulmonary vascular smooth muscle 
(rats, dogs) 
P50HL-15061-07 0013 Response of lung to injury - 

Exchange transfusion in infants with respiratory distress 
syndrome (human, sheep) 
ROIHL 15124-05 Genesis of hypertension in renal disease 

(human, dogs) 
P60HL-15157-07 0011 Comprehensive center for sickle 

cell disease - Development of specific antisickling 
compound (human) 
P60HL-15157-O7 0012 Comprehensive center for sickle 

cell disease - Sickling and intracellular pH (human) 
** P60HL-15160-07 0011 Center for sickle cell disease - 

Study of human sickle cells in an animal model (rats) 
** P60HL-15162-07 0017 Comprehensive sickle cell center - 

Hemoglobin, erythrocytes and sickle cell anemia (human, 
rabbit) 
** P60HL-15162-07 0019 Comprehensive sickle cell center - 

RBC-Blood rheology in sickle cell anemia and related 
disorders (human, animal) 

(contd) 



at the specific level. 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



so 



BLO 



Studies on the control of sicKle cell crisis 



Left ventricular function in exercise 



Hemoglobin and red cell system In 
Rheological studies of sickled cells 



P0lHL-lSt9407 0006 Pathophysiology of 

cardiopulmonary dysfunction - Kinetics of gas exchange- 
Velocity of Bohr effect in erythrocytes (human) 
P01HI.1519407 0009 Pathophysiology of 

cardiopulmonary dysfunction ■ Kinetics of gas exchange- 
Diffusion and erythrocytes reaction rates (human, dogs) 
POlHL-15194-07 0022 Pathophysiology of 

cardiopulmonary dysfunction - Kinetics of gas exchange - 

Pulmonary carbon dioxide exchange (dogs) 
ROlHL-15226-06 Interaction of blood cells with fibrinogen 

and fibrin (human, animals) 
ROlHL'15722-06 Hemorrheology studies related to in vivo 

blood flow (human) 
P60HL-1 5996-06 0010 Cincinnati comprehensive sickle 

cell center - Whole blood viscosity in sickle cell anemia 

(human) 
P60HL-15999-05 0014 Miami comprehensive sickle cell 

center - Biochemical and morphological parameters of 

sickle cells (human) 
P60HL-1 5999-05 0021 Miami comprehensive sickle cell 

center - Diphosphonates-Eiythrocyte calcium loading, 

maturation (human, chick embryo) 
P60HL-1600806 0014 Wayne State University 

comprehensive sickle cell center - Zinc and red blood cell 

metabolism in sickle cell anemia (rats, human) 
P60HL-1600g-06 0016 Wayne State University 

comprehensive sickle cell center - Red blood cell glycolysis 

In sickle cell patients 
P60HL-16008-06 0017 Wayne State University 

comprehensive sickle cell center - Oxygen transport kinetics 

of pre- and post-sickling cells (human) 
ROlHL-16093-05 Functional properties of hemoglobin and 

erythrocytes 
ROlHL-16421-08 Determinants of RBC deformability and 

capillary flow (human, mice) 
R01HL-16580-04 Mathematical models for studying sickle- 
cell disease 
ROlHL-16647-05 

(human) 
ROlHL-16656-06 

(dogs) 
POlHL-16833-04 0009 

hemoglobinopathies - 

(human) 
POlHL-16833-04 0016 Hemoglobin and red cell system in 

hemoglobinopathies - Calcium-indiced membrane damage 

In Hb SS disease (human, animals) 
POlHL-16851-04 Human red cell membrane in health and 

disease 
P01HI-168S1-04 0009 Human red cell membrane in 

health and disease - Blood cell properties in circulatory 

regulation (dogs, rabbits) 
POlHL-16851-04 0011 Human red cell membrane in 

health and disease - Ultrastructure laboratory-Core facility 
POlHL-16910-05 0001 Regulation of the peripheral 

circulation - Quantitative studies of microcirculatory control 

(bats) 
ROlHL-16931-04 Red cell storage and transfusion 

(human, animals) 
ROlHL-17571-03 Study of membrane permeability by NMR 

relaxation (human) 
ROlHL-17808-03 Effect of altered oxygen affinity on 

oxygen transport (human, rats) 
ROlHL-1 7878-04 Structural studies of the human 

erythrocyte membrane 
ROlHL-17881-15 Biosynthesis and degradation of blood 

group substances (human, animals) 
ROlHL-17963-04 Human erythrocyte carbonic anhydrase 
ROlHL-17967-04 Limiting factors in oxygen uptake in the 

lung 
' ROlHL-18082-03 Erythrocyte phosphates and vertebrate 

gas transport (amphibians, reptiles) 
POlHL-18208-04 Center for the study of blood cell 

rheology 
POlHL-18208-04 0001 Center for the study of blood cell 

rheology - Physiological basis of reversible erythrocyte 

shape change (human, firefly) 
' POlHL-18208-04 0002 Center for the study of blood cell 

rheology - Holography of RBC shape (human) 
POIHL-18208-04 0004 Center for the study of blood cell 

rheology - Splenic microcirculation (rats, mice) 
' P01HL-lg208-04 0005 Center for the study of blood cell 

rheology - RBC deformability and capillary flow 

interrelations (human, mice) 
POlHL-18208-04 0006 Center for the study of blood cell 

rheology - Analysis of flow in arterioles and capillaries 

(human) 
ROIHL- 182 56-01 Optical properties of platelets and 

erythrocytes (rabbits, dogs, human) 
ROlHL-18284-04 Aging erythrocytes-Blo-recognition and 

elimination (monkeys) 
ROIHL-18328-03 Hemoglobin function and tissue 

oxygenation (human, dogs) 
' R01HL-18S51-03 Spectrin, actin, lipid and red cell 

membrane structure 
' ROlHL-18660-03 Neurotransmitter receptors in human 

Cfythrocytes 
R01HL-1872S-03 

process (human) 
ROlHL-18818-04 



Light-scattering studies of the sickling 



Stereochemical mechanism of sickling of 



hemoglobin S (human) 



ROIHL- 194 19-03 Cellular interactions with foreign 
materials (mammals) 
** ROlHL-19532-01 Oxygen toxicity in the red cell (human) 
POlHL-19737-02 0008 Cellular and molecular aspects of 
respiratory physiology - Kinetics of movement of acid 
metabolites from cell to capillary blood (dogs) 
ROlHL-19824-02 Mass transfer in the microcirculation 
R01HL-1994e-03 Reduction of Iron overload in 
thalassemia (children, rabbits, dogs, monkeys) 
ROlHL-20074-02 Structure and function of amidinated 
human hemoglobin 
** ROlHL-20 177-02 Effects of erythrocyte deformability on 
tissue perfusion (rats) 
ROlHL-20520-03 Protein modification-The key to diabetic 
sequelae (human, animal) 
** ROlHL-207 11-01 Structure-function relationships in red 

cell NA-K pumps (goats) 
** ROlHL-20882-02 Interactions of plasma lipoproteins with 

erythrocytes (Rhesus, human) 
** ROlHL-20902-02 Studies on marginal band system of 
erythrocytes (amphibians, reptiles, fish) 
ROlHL-20925-01 The acetylation of fetal hemoglobin 
(human) 
** ROlHL-20943-02 Comparision of microsphere and RBC 

behavior in vivo 
** P60HL-20985-01 0003 Northern California sickle cell 
center - Kinetics of sickling and clinical manifestations in 
sickling disorders (human) 
** P60HL-20985-01 0004 Northern California sickle cell 
center - Characterization of irreversibly sickled cells 
(human) 
** P60HL-20985-01 0006 Northern California sickle cell 

center - Antisickling properties of imidoesters (human, rats) 
POlHL-21016-02 0001 Sickle cell anemia and other 
hemoglobinopathies - Supramolecular models of Hb S- 
Mutational and EM approach 
** POlHL-21016-02 0006 Sickle cell anemia and other 
hemoglobinopathies - Analysis of the oxygen dissociation 
curve of Hb S-containing red cells 
R23HL-2 11 29-02 The antisickling effects of imidoesters 
ROlHL-21 179-01 Volume regulation -Role of the membrane 
potential (amphiuma) 
** R23HL-2 13 28-02 The I blood group antigen of human 

erythrocyte membrane 
** ROlHL-21845-01 Human red cell membrane-Structure and 
function 
ROlHL-21995-01 Protein phosphorylation and adrenergic 
effects 
** ROlHL-22123-02 The role of the red cell in diabetic 
atherosclerosis (human) 
POlHL-22 163-01 0002 Surface thrombogenesis- 
Mechanisms and prevention - Laser-scattering detection of 
microemboli in blood flow (baboons) 
ROlHL-22233-01 Characterization of bio-materials by 

elastic property 
ROlHL-22555-01 Structure and function of platelet 
activating factor (rabbits, human) 
** ROlHL-22671-01 Removal of senescent and stored human 

red cells 
** ROlHL-23200-01 Isolation of CA binding proteins from 
erythrocytes (human) 
ROlHL-23900-01 Mechanical measurement of cell 

membrane viscosity (human) 
ROlHL-23983-01 Quantitative radiocardiography (human, 
dogs) 

BLOOD CELLS, ERYTHROCYTES, HEMOLYSIS 

SEE ALSO BLOOD AND RE DISORDERS, ANEMIA HEMOLYTIC 
SEE ALSO BLOOD (HEMATOLOGIC) TESTS, OSMOTIC 

FRAGILITY* 
SEE ALSO BLOOD TOXICOLOGY, HEMOLYSINS 
** R01HL-07652-14 Destruction of red blood cells in 

hemolytic anemias (human, guinea pigs) 
ROlHL-12839-09 Flow, transport and membrane 

phenomena in blood (human) 
POlHL-13738-08 0002 Cardiac assist devices and 

artificial hearts - Total replacement with artificial heart 

(calves, sheep, ponies) 
POlHL-13738-08 0003 Cardiac assist devices and 

artificial hearts - Pathophysiological effects of the artificial 

heart (calves) 
POlHL-13738-08 0004 Cardiac assist devices and 

artificial hearts - Hematological evaluation of prosthetic 

materials (calves) 
POlHL-13738-08 0005 Cardiac assist devices and 

artificial hearts - Development of new materials for 

artificial heart and assist devices (sheep, dog) 
ROlHL-13803-07 Advanced cardiac valvular and vascular 

prosthesis (dogs, baboons) 
P50HL-142 17-08 0051 Specialized center of research in 

thrombosis - Microcirculation section (bat, hamster) 
ROlHL-15793-06 Molecular aspects of erythrocyte 

membrane resealing (human) 
P60HL-15999-05 0014 Miami comprehensive sickle cell 

center - Biochemical and morphological parameters of 

sickle cells (human) 
P60HL-16005-05 0022 Comprehensive sickle cell center - 

Regulation of erythropoiesis in patients with sickle cell 

anemia 
** R01HL-ie421-08 Determinants of RBC deformability and 

capillary flow (human, mice) 
ROlHL-16711-05 RBC and endothelial membrane material 

characteristics (human) 



Hemoglobin and red cell system in 
Erythrocyte membrane damage in Hb 



POlHL-16833-04 0014 

hemoglobinopathies 

SS disease (human) 
P01HL-ie851-04 0003 Human red cell membrane in 

health and disease - Modeling membrane mechanics and 

blood rheology 
ROlHL-16938-05 Effect of physical forces on blood (dogs, 

human) 
P60HL- 17269-04 0032 National heart and blood vessel 

research and demonstration center - Clinical circulatory 

assist device fabrication 
POlHL-17731-04 0010 Physiological basis of pulmonary 

disease - Gas exchange kinetics (dogs) 
** ROlHL-18012-04 Cellular defects in nocturnal 

hemoglobinuria (human) 
" ROlHL-18163-04 Red cell membrane effects due to 

oxidizing agents 
** POlHL-18208-04 0004 Center for the study of blood cell 

rheology - Splenic microcirculation (rats, mice) 
P50HL-18828-03 0004 Specialized center of research in 

thrombosis - Membrane changes in platelet physiology-Role 

of complement (mice, human) 
** ROlHL-19163-02 Piscine erythrocytic necrosis in the 

Atlantic cod 
** ROlHL-19164-03 Piscine erythrocytic necrosis in the 

Atlantic cod 
** P60HL-20985-01 0007 Northern California sickle cell 

center - Immunohematologic abnormalities in sickle cell 

anemia (human) 
ROlHL-23654-01 Selected topics on blood transfusion 

(rabbits, human) 

BLOOD CELLS, ERYTHROCYTES, RETICULOCYTES 

ROlHL-06950-17 Red cell metabolism (human, 

vertebrates) 
P60HL-16008-06 0018 Wayne State University 

comprehensive sickle cell center - Hemoglobin S and RBC 

membranes-Pathogenesis of irreversibly sickled cells 
POlHL-18208-04 0003 Center for the study of blood cell 

rheology - Bone marrow microcirculation (rats, mice) 
ROlHL-19324-02 Mechanisms of the inhibition of sickling 

by DBA (human) 
ROlHL-20859-02 Beta adrenergic catecholamine receptor 
POlHL-2 10 16-02 0005 Sickle cell anemia and other 

hemoglobinopathies - Ligand kinetics in normal and Hb S 

containing erythrocytes (human) 
POlHL-21016-02 0011 Sickle cell anemia and other 

hemoglobinopathies - Metabolic effects of antisickling 

agents (hamsters) 
ROlHL-23736-04 Sickle cell anemia and hemoglobin 

synthesis (monkeys) 

BLOOD CELLS, HEMATOPOIETIC STEM CELLS 
(GENERAL) 

SEE ALSO BLOOD CELLS, ERYTHROBUSTS AND ERYTHROID 
STEM CELLS 
** ROlHL-15685-05 Hemopoietic regulators produced in cell 
culture (human, animals) 
POIHL- 174 17-05 0004 Experimental lung transplantation 
- Methods for suppressing lung allograft rejection (dogs, 
mice) 
ROlHL-18186-04 Cardiac allografts in autologous 
radiation chimeras (rats, dogs) 



ROlHL-19333-03 
ROlHL-20826-02 

control (mice) 
ROlHL-20912-02 

thassemic mice 
ROlHL-22555-01 



Hematopoietic chimerism (mice, monkey) 
Megakaryocyte proliferation and its 

Control on non-alpha chain synthesis in 



Structure and function of platelet 
activating factor (rabbits, human) 

BLOOD CELLS, LEUKOCYTES 

SEE ALSO BLOOD CELLS, LYMPHOCYTES 

SEE ALSO BLOOD CELLS, MONOCYTES 

SEE ALSO BLOOD TREATMENT, LEUKAPHERESIS 

SEE ALSO HYPERSENSITIVITY, TRANSFER FACTOR 

(HYPERSENSITIVITY) 
SEE ALSO IMMUNOLOGY, ANTIBODIES, HEMAGGLUTININS, 
LEUKO-AGGLUTININS 
POlHL-06350-17 0019 Hemostasis research program 

project - Microcirculation (human, rats, rabbits) 
POlHL-09011-15 0001 A research and resource program 
in blood - Genetic markers of human blood and gene 
mapping (human) 
ROlHL-12 138-08 Nutritional regulation of enzyme activity 

(rats, human) 
ROlHL-12745-10 Enzymes and inhibitors of cholesterol 

biosynthesis (rats, human, swine) 
ROlHL-12833-09 Genetic and environmental influences on 

lung disease (human) 
ROlHL-13336-09 Biochemistry and physiology of human 

platelets 
PSOHL-14217-08 0050 Specialized center of research in 

thrombosis - Electron microscopy section (dogs) 
P50HL-14217-08 0052 Specialized center of research in 
thrombosis - Radioisotope nuclear medicine section 
(human, dog) 
P50HL-14230-07 0093 A/S SCOR -Lipids, atherosclerosis 
and thrombosis - Clinical studies involving cellular lipid 
content (human) 
** ROlHL-14262-07 Leukocyte proteases and their lung 
targets (human, dogs, rabbits) 

(contd) 



*EKMes nwtinc meltiodohity OR ewers only general projects which preclude Indexing at the specifk level. 
"'^laiiK', si^niHcanUy to alOM ubicct. 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



BIO 



SI 



• LO 



ROIHL 14739 06 Ihe colt of Itukocytts In thrombotic 

disMs* (hum«nc da|>) 
POIHl 1498S07 0011 Adaptation (0 tiypoali 

Prosli|l(ndins in llw control ol the pulmonary circulation 

(animals) 
RCIHI Ib22e06 Interaction ol blood cells with librinogen 

and tibrin (human, animals) 
POIHL 1S48606 0003 Studies on thrombosis 

Mechanism and prevention ol tibiinopeplide 6 degradation 

(human) 
ROIHL IMS) 06 Blood coagulation Platelet plasma 

protein interaction (human) 
POIHL IS83? 06 0004 Chemical structural predispositions 

to lung injury Pioteohrtic activity leucocytes in patients 

with obstructive lung disease 
P60HL lS999 0b 0008 Miami comprehensive sicMe cell 

center Cyanate eftect on host defense Cellular and 

humoral (human, guinea pig. rabbits) 
POIHL 168M 04 0001 Human red cell membrane in 

health and disease Rheology of erythrocyte membrane 

(human, amphiuma) 
POIHL 16851 04 0003 

health and disease 

blood rtieology 
POIHL- 16851 04 0008 

health and disease 

(human) 
POIHL 16851 04 0009 

health and disease 



Human red cell membrane in 
Modeling membrane mechanics and 



Human red cell membrane in 
Force balance in red cell interactions 



Human red cell membrane in 
Blood cell properties in circulatory 
regulation (dogs, rabbits) 
POIHL 16851 04 0011 Human red cell membrane in 

health and disease Ultrastructure laboratory-Core facility 
** ROIHL 16938 05 Effect of physical forces on blood (dogs. 

human) 
** ROlHL-17437-03 Perfusion lung' -Role of traumatized 

leukocytes (dogs, human) 
** ROlHL-1759603 Lcukocyte-endothelial interactions (rats) 
P01HL1781204 0007 Thrombosis and plasma proteins ■ 
Blood components-Response to endotoxin (dogs, baboons) 
** ROlHL-17964-04 The alternate pathway for fibrinolysis 
(human) 
ROIHL 18012-04 Cellular defects in nocturnal 
hemoglobinuria (human) 
M POIHL- 18208-04 Center for the study of blood cell 
rheology 
POIHL- 1820804 0001 Center for the study of blood cell 
rheology - Physiological basis of reversible erythrocyte 
shape change (human, firefly) 
ROlHL-19223-03 Control of cholesterogenesis in leukocytes 

and liver (rats, human) 
R01HL19777-03 Regulation of hypersensitivity in the lung 

(rats, guinea pigs, rabbits, human) 
ROlHL-20220-03 Anaphylatoxins as inflammatory and 

chemotactic agents (guinea pig. rabbit, human) 
ROlHL-20875-02 Chronic obstructive pulmonary disease- 
Familial/genetic (human) 
** R01HL-20971-10 Membrane glycoproteins of platelets and 

leukocytes (human) 
** ROlHL-2 1548-01 Pathogenesis of pulmonary 
thromboembolic disease (human, mammals) 
ROlHL-22053-02 The disordered lipid metabolism of 

diabetes mellitus (chickens, mammals, human) 
ROlHL-22257-01 Leukokinesis enhancing factor and lung 

infections (human, rats) 
R23HL-22346-01 Hematological injury and pulmonary 
dysfunction (human, mammals) 
** R23HL-22437-01 Leukotactic mediators in lung 
inflammatory reactions (rats, rabbits, human) 
ROlHL-2247001 Liposome myocardial uptake in infarct 
and ischemia (dogs. rats, mice) 
** ROlHL-2258501 Plasma proteins adsorbed to artificial 
organs (human, rabbits) 
ROlHL-22738-01 Role of bioelectric potentials in platelet 

adherence (bats, rats, hamsters) 
ROlHL-23586-06 Pharmacologic control of hypersensitivity 

phenomena (human) 
ROlHL-23595-01 Experimental emphysema-Depression of 
protease inhibitors (rats, hamsters) 

BLOOD CELLS, LEUKOCYTES, BASOPHILS 

SEE ALSO BLOOD AND RE SYSTEM. MAST CEUS 
P50HL-14153-07 0015 Johns Hopkins Lung Center- 
Chronic diseases of airways - Kinins and human lung 
** R23HL-21089-O2 Localization of mediators in dispersed 

lung cells (guinea pigs, human) 
" ROlHL-22555-01 Structure and function of platelet 
activating factor (rabbits, human) 

BLOOD CELLS, LEUKOCYTES, EOSINOPHILS 

POlHL-06835-17 0060 Cardiovascular disease - 
Ventricular performance experimental models of arterial 
hypertension (rats, dogs) 

R23HL-21134-02 Immune function and fibrogenesis in 
silicosis (guinea pigs) 

BLOOD CELLS, LEUKOCYTES, GRANULOCYTES 
(GENERAL) 

SEE ALSO BLOOD AND RE DISORDERS. LEUKOCYTE 
DISORDERS. AGRANULOCYTOSIS 
** NOlHB-62970-02 Collection, function and transfusion of 

granulocytes 
** NOlHB-62971-03 Collection, function and transfusion of 
granulocytes 



N0IH6 629/2 05 
granulocytes 

NOIHB 629/3 05 
granulocytes 

ROIHL 06242 18 

ROIHL 147/8 10 



Collection, tunctioii nod transfusion of 



Collection, lunclmn and transfusion ol 



Kinetic studies ol blood (human) 
Proteolytic en/ymns and inhibitois in 

lung disease (mammals, human) 
ROIHL 15685 05 Hemopoietic regulators produced in cell 

culture (human, animals) 
ROIHL 16254 05 Pathogenesis of bubble and clot 

formation (fish) 
" P60Ht 1/265 04 0009 Community blood resource center 

support Research Developing granulocyte transfusion 

therapy (human, rabbit) 
POIHL 185/6-03 0009 Thrombosis research program 

project Biology of factor VII (human, rabbits, cattle) 
POIHL 185 77 03 0001 Lipoproteins Cell surface 

interactions Structural studies of serum lipoproteins in 

man and dogs 
** ROIHL 1972503 Complement induced pulmonary injury 

(dogs, rabbits, sheep) 
** ROIHL 20807 02 Detection of familial hypercholesterolemia 

(human) 
POIHL 20994-02 0005 Dynamics of neutrophil elastase in 

the lung - Protease inhibitors in pulmonary inflammation 

and emphysema (rabbits) 
R23HL22621 01 Blood cell mediated pulmonary (human) 
ROlHL-23899-01 Flow and flexing at blood/biomaterial 

interfaces 

BLOOD CELLS, LEUKOCYTES, NEUTROPHILS 



POIHL 06314 17 0046 
cardiovascular disease 
(human, mice) 

POlHL-06314 17 0052 
cardiovascular disease 



Immunologic mechanisms in 
Mediators of immune injury 



Immunologic mechanisms in 
Role of cyclic nucleotides in 

neutrophil function (human) 
R01HL09125-14 Ultrastructural cytochemistry (human. 

chick) 
ROlHL-14700-05 Humoral and lung protease-antiprotease 

role in obstructive disease (human) 
ROlHL-15647-06 Hematopoietic studies of cyclic 

hematopoiesis (dogs) 
POlHL-15832-06 0004 Chemical-structural predispositions 

to lung injury Proteolytic activity leucocytes in patients 

with obstructive lung disease 
P01HL-1S832-06 0009 Chemical-structural predispositions 

to lung injury - Immunology-Enzyme degradation products 

of human lung elastin and microfibril 
P60HL- 15999-05 0008 Miami comprehensive sickle cell 

center - Cyanate effect on host defense -Cellular and 

humoral (human, guinea pig, rabbits) 
P60HL-16008-06 0015 Wayne State University 

comprehensive sickle cell center - Trace elements in sickle 

cell disease (human) 
POlHL-16769-05 0002 Pathobiologic and host defense 

reactions in the lung - Pathogenesis of complement 

dependent injury to the lungs (rabbits) 
POlHL-16769-05 0004 Pathobiologic and host defense 

reactions in the lung - Pathogenesis of Pseudomonas and 

Serratia pneumonias (rabbits) 
P60HL-I7265-04 0009 Community blood resource center 

support - Research-Developing granulocyte transfusion 

therapy (human, rabbit) 
P50HL-18828-03 0005 Specialized center of research In 

thrombosis - Platelet inflammatory factors in thrombosis 

(human, guinea pig) 
ROlHL-19072-03 Modification of tissue injury in 

myocardial infarction (dogs, human) 
ROlHL-194 19-03 Cellular interactions with foreign 

materials (mammals) 
ROIHL- 196 28-03 Mechanisms of pulmonary alveolar 

proteinoses (human, rats) 
ROlHL-19721-03 Lung inflammation-Lysosomal proteases 

and liposomes (human, rabbits) 
ROlHL-19741-03 Murine CRD-A model of chronic 

pulmonary inflammation (mice, rats) 
ROlHL-197 79-03 Biochemical basis of oxygen damage to 

lung cells (guinea pigs, rats) 
ROIHL- 198 06-03 Chemotactic control of airway phagocytes 

(human, rabbits) 
ROlHL-20002-03 Pulmonary complications of viral 

infections (children) 
ROlHL-203 14-02 Host defense against S pheumoniae in 

sickle cell disease (human) 
POIHL-20994-02 Dynamics of neutrophil elastase in the 

lung 
POlHL-2099402 0001 Dynamics of neutrophil elastase in 

the lung - Dynamics of neutrophil elastase in normal 

animals (dogs, rabbits) 
POlHL-20994-02 0002 Dynamics of neutrophil elastase in 

the lung - Neutrophil and neutrophilic elastase in human 

lungs 
POlHL-20994-02 0003 Dynamics of neutrophil elastase in 

the lung - Neutrophil elastase flux in models of lung 

disease (dogs) 
POlHL-20994-02 0007 Dynamics of neutrophil elastase in 

the lung - The etiology of experimental emphysema (dogs) 
R23HL-21 116-02 Mechanisms of membrane and tissue 

damage in lung (dogs, rabbits) 
R23HL-21 134-02 Immune function and fibrogenesis in 

silicosis (guinea pigs) 



N2IHI 21805 01 Tutu* cell inlwictioni with vatiular 

prostheses (human, rat-., mice) 
R23HI 2199/ 01 Pulmonary immunopalhology in Ihn 

compromised host (guinea pigs) 
ROIHI 22555 01 Structure and tuntlion of pl»l»li-l 

activating factor (rabbits, human) 
•• R23HI 22823 01 Phagocylit and immune defense 

mechanisms of the lung (mice) 
ROIHI 23161 01 0005 Biology ol myocardial ischemia 

Localization ol r.omplemcnl in myocardial Inlifction (dog) 

BLOOD CELLS, LYMPHOCYTES 

NOIHB 72919 08 Hemoglobin carhamylalnn in Ihe 

treatment of sickle cell anemia (human, dogs) 
ROIHL 03180 21 Relation of lymphatics to 

cardiopulmonary function (dogs) 
POIHL 06314 1/ Immunologic mechanisms in 

cardiovascular disease 
POIHL 06314 17 0048 

cardiovascular disease 

(rats, mice) 
POIHL 06314 1/ 0050 

cardiovascular disease 



M 



Immunologic mechanism] in 
Pathogenesis ol glomerulonephrrtis 



Immunologic mechanisms in 
Physiologic changes in 

lymphocytes (human, mice) 
POIHL 06314 17 0052 Immunologic mechanisms in 

cardiovascular disease Role ol cyclic nucleotides in 

neutrophil function (human) 
P01HL06314 17 0059 Immunologic mechanisms in 

cardiovascular disease Immunogenetic response to 

streptococcal antigens in man 
POlHL-06314 17 0064 Immunologic mechanisms in 

cardiovascular disease Diabetic vascular disease (human. 

rats, mice) 
POlHL-06370 17 0004 Cardiopulmonary and renal 

pathology research center Lymphocytes in graft rejection 

and immune surveillance (human) 
ROlHL-07652-14 Destruction of red blood cells in 

hemolytic anemias (human, guinea pigs) 
ROlHL-09125-14 Ultrastructural cytochemistry (human. 

chick) 
POlHL-13108-09 0013 Clinical heart transplantation 

Cardiomyopathic lymphocyte responsiveness to cultured 

endothelium 
POlHL-13108-09 0016 Clinical heart transplantation - 

Total lymphoid irradiation for immune response (dogs) 
ROlHL-13885-08 0006 Cystic fibrosis and pulmonary 

disease - Cell mediated immunity and Pseudomonas 

infections in cystic fibrosis (human) 
ROlHL-13885-08 0008 Cystic fibrosis and pulmonary 

disease - Pseudomonas specific activation of alveolar 

macrophages (human, rabbits) 
P60HL- 15999-05 0008 Miami comprehensive sickle cell 

center - Cyanate eflect on host defense-Cellular and 

humoral (human, guinea pig. rabbits) 
POlHL-16411-04 0003 Blood systems in coagulation and 

vessel disease Molecular events involving the late stages 

of coagulation (rabbits) 
POlHL-16748-05 Cellular and immunological basis of 

pulmonary diseases 

Cellular and immunological basis 
Sarcoidosis -Studies with bronchial 



Pathobiologic and host defense 
Immunogenetic factors in 



POlHL-1674805 0006 

of pulmonary diseases 

lavage (human) 
POlHL-16769-05 0007 

reactions in the lung 

sarcoidosis (human) 
ROlHL-17487-04 Adrenergic-vasoregulation interactions in 

hypertension (human) 
ROIHL- 17 595-03 Leukocyte-endothelial interactions (rats) 
ROlHL-18936-02 Heart preservation and transplantation 

studies (rat) 
ROIHL- 1965 1-03 Host factors in pathogenesis of 

respiratory disease (human, hamsters) 
ROlHL-20807-02 Detection of familial hypercholesterolemia 

(human) 
POlHL-20948-02 0002 Molecular basis of cholesterol 

metabolism - LDL pathway in cell lines with informative 

properties other than fibroblasts 
POlHL-20948-02 0003 Molecular basis of cholesterol 

metabolism - LDL pathway in vivo (human, rats, guinea 

pigs) 
POlHL-20948-02 0004 Molecular basis of cholesterol 

metabolism - Genetic analysis of the LDL pathway (human) 
POlHL-20948-02 9001 Molecular basis of cholesterol 

metabolism - Tissue culture core laboratory 
ROlHL-21156-02 

lung disease 
ROlHL-21565-02 



Antitrypsin and other causes of chronic 
Pathogenesis of inflammatory lung injury 



(rats, rabbits) 
ROlHL-22415-01 Mechanisms responsible for disease 

severity in asthma (human) 
** ROlHL-22456-01 Lipoproteins in bioregulation of the 

immune response (mice, human) 
ROlHL-22555-01 Structure and function of platelet 

activating factor (rabbits, human) 
POlHL-22602-01 0003 Pathophysiology of the 

endothelium - Mechanisms of endothelial proliferation 

(human, animals) 

BLOOD CELLS, B LYMPHOCYTES 

** POlHL-06314-17 0066 Immunologic mechanisms in 

cardiovascular disease - Sensitization, cell-mediated 
cytotoxicity, role of lymphocytes (human, mice) 

(contd) 



'Excludes rautirw melhodokxy OR cavers only general projects which preclude indexing at the specific level. 
"Oiieiited significantly to above subject 



M Grant has subprojects descnbing specific research aspects. 
See Appendix for investigator's name and grant number 



BLO 



52 



BLO 



** POlHL-0631417 0067 Immunologic mechanisms in 

cardiovascular disease - Mitogenic and antigenic activation 

of lymphocyte sub-populations 
P01HLC6370-17 0001 Cardiopulmonary and renal 

pathology research center - The humoral and cellular 

mechanisms of allograft rejection (monkeys) 
POlHL-06370-17 0014 Cardiopulmonary and renal 

pathology research center - Quantitative morphology in 

cardiac disease (human, rats, dogs) 
POlHL-06370-17 0018 Cardiopulmonary and renal 

pathology research center - Cytochemistry and immunology 

of lymnhoproliferative disorders (human) 
POlHL-06835-17 0060 Cardiovascular disease ■ 

Ventricular performance experimental models of arterial 

hypertension (rats, dogs) 
P50HL-14212-07 0014 Correlated studies of pulmonary 

fibrosis - Pulmonary lavage cells, secretions in diffuse 

intersititial lung disease (human) 
P50HL 15061-07 0006 Response of lung to injury ■ 

Complement synthesis by pulmonary macrophages (guinea 

pigs, human) 
P60HL-16008-06 0019 Wayne State University 

compiehensive sickle cell center - Cell mediated immunity 

in sickle cell anemia (human) 
P01HL-lb748-05 0002 Cellular and immunological basis 

of pulmonary diseases - Immunological function of alveolar 

macrophages (rabbits, sheep, mice) 
POlHL-16769-05 0010 Pathobiologic and host defense 

reactions in the lung - Bronchus associated lymphoid 

tissue and delayed hypersensitivity (rabbits) 
POIHL 18646-03 0001 Studies basic to heart 

transplantation - Individualized regulation of 

immunosuppression (dogs, rats) 
POlHL-18646-03 0002 Studies basic to heart 

transplantation - Detection of rejection (dogs) 
POlHL-18646-03 0004 Studies basic to heart 

transplantation - Presensitization-Detection, incidence and 

clinical significance 
POlHL-18646-03 0006 Studies basic to heart 

transplantation - Reduction or elimination of existing 

presensitization (human, animals) 
POlHL-18646-03 0009 Studies basic to heart 

transplantation - Pathologic aspects of cardiac allograft 

rejection (sheep, dogs) 
POlHL-19717-02 0041 Response of the lung to injury - 

Cellular immunity in interstitial lung disease (human) 
ROlHL-19/41-03 Murine CRD -A model of chronic 

pulmonaiy inflammation (mice, rats) 
R01HL19779-03 Biochemical basis of oxygen damage to 

lung cells (guinea pigs, rats) 
ROIHL 20095-03 Role of lymphokines and monocytes in 

lung fibrosis (human, guinea pigs, rats) 
R23HL-21 134-02 Immune function and fibrogenesis in 

silicosis (guinea pigs) 
R23HL-21212-02 Alveolar macrophage function in 

Pseudomonas infection (dgs) 
ROlHL-22301 01 Immunogenetics of chronic pulmonary 

inflammation (mice) 
ROlHL-22456-01 Lipoproteins in bioregulation of the 

immune response (mice, human) 
ROlHL-23631-01 Immunogenetic factors in allergic 

respiratory diseases (human) 

BLOOD CELLS, T LYMPHOCYTES 

" POlHL-06314-17 0066 Immunologic mechanisms in 

cardiovascular disease - Sensitization, cell-mediated 

cytotoxicity, role of lymphocytes (human, mice) 
*' POlHL-06314-17 0067 Immunologic mechanisms in 

cardiovascular disease • Mitogenic and antigenic activation 

of lymphocyte sub-populations 
POlHL-06370-17 0001 Cardiopulmonary and renal 

pathology research center - The humoral and cellular 

mechanisms of allograft rejection (monkeys) 
POlHL-0637017 0014 Cardiopulmonary and renal 

pathology research center - Quantitative morphology in 

cardiac disease (human, rats, dogs) 
POIHL 0637017 0018 Cardiopulmonary and renal 

pathology research center - Cytochemistry and immunology 

of lymphoproliferative disorders (human) 
ROIHL 0869615 0019 Orthotopic heart transplantation ■ 

Suppressor cell stimulation (dogs, mice) 
POlHL-1310809 0003 Clinical heart transplantation - 

Endomyocardial biopsy pathology 
** POIHL 13108 09 0012 Clinical heart transplantation - 

Human T cell sheep erythrocyte receptors 
POlHL-13108-09 0015 Clinical heart transplantation ■ 

Antithymocyte globulin analysis and clinical effects 
P50HL-I4212-07 0014 Correlated studies of pulmonary 

fibrosis - Pulmonary lavage cells, secretions in diffuse 

intersititial lung disease (human) 
P50HL 1506107 0006 Response of lung to injury - 

Complement synthesis by pulmonary macrophages (guinea 

pigs, human) 
P60HL- 16008-06 0019 Wayne State University 

comprehensive sickle cell center - Cell mediated immunity 

in sickle cell anemia (human) 
R01HL16651-05 Evaluation of steroid therapy in 

sarcoidosis (human) 
POlHL-16748-05 0002 Cellular and immunological basis 

of pulmonary diseases - Immunological function of alveolar 

macrophages (rabbits, sheep, mice) 



POlHL-16769-05 0008 Pathobiologic and host defense 

reactions in the lung - Pulmonary immunocytologic defense 

mechanisms against bacteria (human, animals) 
POlHL-16769-05 0010 Pathobiologic and host defense 

reactions in the lung - Bronchus associated lymphoid 

tissue and delayed hypersensitivity (rabbits) 
ROlHL-17404-05 Immunologic mechanisms in heart 

disease (mice) 
POlHL-174 17-05 0003 Experimental lung transplantation 

- Methods for detecting lung allograft rejection (dogs) 
P01HL18646-03 0001 Studies basic to heart 

transplantation - Individualized regulation of 

immunosuppression (dogs, rats) 
POlHL-18646-03 0004 Studies basic to heart 

transplantation - Presensitization-Detection, incidence and 

clinical significance 
POlHL-18646-03 0006 Studies basic to heart 

transplantation - Reduction or elimination of existing 

presensitization (human, animals) 
P01HL18646-03 0009 Studies basic to heart 

transplantation - Pathologic aspects of cardiac allograft 

rejection (sheep, dogs) 
POlHL-197 17-02 0041 Response of the lung to injury ■ 

Cellular immunity in interstitial lung disease (human) 
ROlHL-19741-03 Murine CRD -A model of chronic 

pulmonary inflammation (mice, rats) 
ROlHL-19760-01 Cellular immune responses of the lung 

(mice, guinea pigs) 
ROlHL-19774-03 Pathogenesis of chronic lung disease 

(rats, mice, bacteria) 
ROlHL-19779-03 Biochemical basis of oxygen damage to 

lung cells (guinea pigs, rats) 
ROlHL-20095-03 Role of lymphokines and monocytes in 

lung fibrosis (human, guinea pigs, rats) 
R23HL-21134-02 Immune function and fibrogenesis in 

silicosis (guinea pigs) 
R23HL-212 12-02 Alveolar macrophage function in 

Pseudomonas infection (dgs) 
ROIHL 21829-01 Etiology of obstructive airway disease in 

children (also monkeys) 
ROlHL-22301-01 Immunogenetics of chronic pulmonary 

inflammation (mice) 
ROlHL-22456-01 Lipoproteins in bioregulation of the 

immune response (mice, human) 
ROlHL-2363101 Immunogenetic factors in allergic 

respiratory diseases (human) 

BLOOD CELLS, T LYMPHOCYTES, HELPER 

R23HL-21089-02 Localization of mediators in dispersed 
lung cells (guinea pigs, human) 

BLOOD CELLS, T LYMPHOCYTES, KILLER 

P50HL-1600806 0019 Wayne State University 

comprehensive sickle cell center ■ Cell mediated immunity 

in sickle cell anemia (human) 
P01HL18646-03 0003 Studies basic to heart 

transplantation - Host responses to xenografts (rodents, 

rabbits) 

BLOOD CELLS, T LYMPHOCYTES, SUPPRESSOR 

ROlHL-22301-01 Immunogenetics of chronic pulmonary 
inflammation (mice) 

BLOOD CELLS, MONOCYTES 

POlHL-06314-17 0067 Immunologic mechanisms in 

cardiovascular disease - Mitogenic and antigenic activation 

of lymphocyte sub-populations 
ROlHL-07652-14 Destruction of red blood cells in 

hemolytic anemias (human, guinea pigs) 
P50HL-15061-07 0009 Response of lung to injury - 

Alveolar macrophages (human, rabbits) 
P60HL16005-05 0020 Comprehensive sickle cell center - 

Studies of the immunologic defect In sickle cell anemia 

(human) 
R01HL17581-03 Patent ductus arteriosus and pulmonary 

hypertension (dogs) 
POlHL-18646-03 0009 Studies basic to heart 

transplantation - Pathologic aspects of cardiac allograft 

rejection (sheep, dogs) 
ROlHL-19731-03 Collagen in interstitial fibrosis of lung 

(human) 
R01HL-19732-03 Lymphokines in pulmonary 

granulomatous inflammation (mice) 
** ROlHL-20095-03 Role of lymphokines and monocytes in 

lung fibrosis (human, guinea pigs, rats) 
** ROlHL-20807-02 Detection of familial hypercholesterolemia 

(human) 
** ROlHL-22474-01 Cholesterol metabolism and 

atherosclerosis (rats, human, rabbits) 
ROlHL-22555-01 Structure and function of platelet 

activating factor (rabbits, human) 

BLOOD CENTERS 

SEE BLOOD PRESERVATION. BLOOD BANKS, CENTERS- 
RESOURCES-REGISTRIES 

BLOOD-CEREBROSPINAL FLUID BARRIER 

SEE CEREBROVASCULAR SYSTEM, BLOOD-CEREBROSPINAL 
FLUID BARRIER 

BLOOD CHEMISTRY 

SEE CHEMISTRY. CLINICAL, BLOOD 



BLOOD CIRCULATION DYNAMICS 

SEE CARDIOVASCULAR FUNCTION, BLOOD CIRCUUTION 
DYNAMICS (GENERAL) 

BLOOD CIRCULATION TIME 

SEE CARDIOVASCULAR FUNCTION. BLOOD CIRCULATION TIME 

BLOOD CIRCULATORY SYSTEMS 

SEE ADRENAL CIRCULATION 

SEE CARDIOVASCULAR SYSTEM 

SEE CEREBROVASCULAR SYSTEM 

SEE EYE CIRCULATION 

SEE GASTROINTESTINAL CIRCULATION 

SEE KIDNEY CIRCULATION 

SEE LIVER CIRCULATION 

SEE RESPIRATORY CIRCUUTION 

BLOOD COAGULATION 

SEE ALSO BLOOD PLATELETS 
SEE ALSO BLOOD STASIS 

SEE ALSO CARDIOVASCULAR DISORDERS, EMBOLISM 
SEE ALSO CARDIOVASCULAR DISORDERS, HEMORRHAGE 
SEE ALSO CARDIOVASCULAR DISORDERS, THROMBOSIS 
SEE ALSO VITAMIN K 
N01HB-22919-08 Hemoglobin carbamylation in the 
treatment of sickle cell anemia (human, dogs) 
** R01HL-01662-25 Equilibria in the fibrinogen-fibrin 
conversion (human, cattle) 
P01HL06314-17 0064 Immunologic mechanisms in 

cardiovascular disease - Diabetic vascular disease (human, 
rats, mice) 
** ROlHL-07835-17 Experimental hypertension and renal 
circulation (rats, rabbits) 
ROlHL-10582-12 Thrombosis and hemostasis-Analysis, 
methods and standards (human, cattle, venom) 
** R01HL13198-21 Blood coagulation-Physico-chemical 
properties (human, cattle) 
P01HL-I3737-07 0026 Assisted circulation - Hemostatic 

mechanism (human, dogs) 
POlHL-13738-08 0001 Cardiac assist devices and 

artificial hearts - Cardiac assist devices (human, sheep) 
POlHL-13738-08 0004 Cardiac assist devices and 

artificial hearts - Hematological evaluation of prosthetic 
materials (calves) 
M P50HL-14147-08 Specialized center of research in 

thrombosis 
" P50HL-14147-08 0013 Specialized center of research in 
thrombosis - Mathematical models of blood coagulation 
kinetics 
** P50HL-14147-08 0014 Specialized center of research in 
thrombosis Theoretical models for electrostatic effects in 
blood clot formation 
P50HL-14147-08 0015 Specialized center of research in 

thrombosis - Charge related properties of phospholipid 
surfaces in monolayers and vesicles 
P50HL-14147-08 0016 Specialized center of research in 
thrombosis ■ Nuclear medicine core laboratory (human, 
dogs, rats, rabbits) 
** P50HL-14147-08 0017 Specialized center of research in 

thrombosis - Core coagulation laboratory (human) 
** P50HL-1421708 0055 Specialized center of research in 

thrombosis - Coagulation section -Platelet coagulant activity) 
(human) 
POlHL-15195-04 0004 Program project in biological 

materials - Biological evaluation and surtace interaction 
studies (dogs) 
M POlHL-15486-06 Studies on thrombosis 

POIHL- 15486-06 0003 Studies on thrombosis - 
Mechanism and prevention of fibrinopeptlde 8 degradation 
(human) 
POlHL-15486-06 0004 Studies on thrombosis - 

Thrombosis, intravascuair coagulation, platelet aggregation | 
(dogs) 
** ROlHL-15491-06 Blood coagulation-Platelet-plasma 

protein interaction (human) 
** ROlHL-15593-05 Prolonged extracorporeal cardiopulmonary! 

support (rats, sheep, rabbits) 
** ROIHL- 15887-05 Enzymes of blood coagulation and 
fibrinolysis (human) 
ROlHL-15958-06 X-ray diffraction analysis of thrombin 
and neurotoxin 
** P60HL15996-06 0001 Cincinnati comprehensive sickle 

cell center - Coagulation mechanisms in sickle cell diseasel 
(human) 
** ROlHL-16254-05 Pathogenesis of bubble and clot 

formation (fish) 
M POlHL-16411-04 Blood systems in coagulation and vessel] 

disease 

** POlHL-16411-04 0001 Blood systems in coagulation and] 

vessel disease - Molecular studies of the role of 
complement in blood coagulation (human, rabbits) 
ROlHL-16582-05 Artificial lungs (dogs) 
** ROlHL-16919-05 Proteins of blood coagulation (human. 

bovine) 
** ROlHL-16955-05 Heparin, blood coagulation and lipid 

metabolism (human) 
M POlHL-17430-05 Control of coagulation 

P01HL17430-05 0001 Control of coagulation - Porcine 

von Willebrand's disease 
POlHL-1 7430-05 0002 Control of coagulation - Isolation 

of ristocetin -von Willebrand factor (swine) 
POlHL-17430-05 0005 Control of coagulation - The 

activation of prothrombin (human, cattle, dogs) 



(contd) 



'Excludes routine methodokiey OR covers only general proiects which preclude indexing at the specific level. 
"Oneirted significantly to alwve subject 



M Grant has subprojeds describing specific research aspects. 
See Appendix for investigator's name and grant number. 



BLO 



ROIHl 17S03'03 ViKuItt bubbl«i in dicompitssion 

sickn*si (minlpii. do|. |oit) 
ROIHl i;b2b03 Molgculai basis ol colligan plittid 

intaiiclKin (human, lat) 
ROIHI i;;6903 Naw mathods at studying blood 

coaiulation kinatlcs 
POIHL W812 04 Thiombosis and plasma piotains 
POIHL 1/81204 000b Thiombosis and plasma protams 

In viUo systems ol no(mal platelets, white cells, sera 

(human) 
POIHL 18576 03 Thrombosis research program proiect 
POIHL 18b7603 0011 Thrombosis research program 

prolact Proteolysis and platelet (unction (human, cattle, 

rabbits) 
POIHL 18576 03 0014 Thrombosis research program 

protect Immunology core 
PbOHL 18828 03 Specialiied center ol research In 

thrombosis 
PbOHL 18828 03 0003 Specialiied center of research in 

thrombosis - Structure and lunction of plasma coagulation 

inhibitors (human) 
PbOHL 1882803 0008 Specialized center ol research in 

thrombosis Biochemistry, physiology Platelets and 

subcellular platelet particles (human) 
PbOHL 18828 03 0009 Specialized center of research in 

thrombosis Platelet formation and megakaryocyte cell 

biology (guinea pig. human) 
ROIHL 18834 04 Metal dependent complex formation in 

blood coagulation (human, cattle) 
R01HL19982 02 Blood coagulation-Protein metal lonlipid 

interactions 
ROIHL 2007902 0003 Thromboresistant material Blood 

surlace interactions (human, cattle) 
ROlHL-2016102 Role ol gamma-carboxyglutamic acid in 

blood coagulation (human, cattle) 



The mechanism of action of vitamin K 
Platelet storage at 22 degrees C 

Studies of enzymes in human platelet 



ROlHL-20577-03 
ROlHL-20818-02 

(human) 
R23HL-21490-02 

membranes 
** ROlHL-2154002 Specific inhibitors of coagulation and 

fibrinolysis (rats, rabbits, dogs) 
ROlHL-2176901 Blood compatible benzamidine containing 

polymers 
ROlHL-22270-01 Platelet glycoprotein (human) 
ROlHL-2255501 Structure and function of platelet 

activating factor (rabbits, human) 
** ROlHL-2277101 Thrombogenic phospholipid surfaces 

(cattle) 
ROlHL-2287501 Crotalase-Chemistry, physiology, clinical 

potential (rats, rabbits) 

BLOOD COAGULATION, ACTIVATION PRODUCT 

SEE ALSO BLOOD COAGULATION, FACTOR XI 
SEE ALSO BLOOD COAGULATION, HAGEMAN FACTOR 
R01HL13423-08 Structure-function studies of plasminogen 
and plasmin (human) 
** ROlHL-15817-06 Plasminogen activators from tissues 
(human, pig, cattle) 
ROlHL-16633-04 Chemistry and biology of factor IX 

activator (human, mice, rats) 
ROlHL-17402-04 Mechanism of contact activation of 
intrinsic clotting (human) 
** ROlHL-18859-03 Biochemistry of human factor XI (human) 
ROlHL-20846-02 Purification of bovine plasminogen 

proactivator 
ROlHL-21592-01 Lipoproteins and coagulation factors in 
atherosclerosis (pigeons) 

BLOOD COAGULATION, ANTICOAGULANTS 

SEE ALSO BLOOD COAGUUTION. ANTITHROMBIN 
SEE ALSO BLOOD COAGUUTION. HIRUDEN 
SEE ALSO BLOOD COAGULATION. THROMBOPOIESIS 
INHIBITORS 
ROlHL-01601-30 Blood coagulation and hemorrhagic 

disease (horseshoe crabs) 
ROlHL-01661-27 Hemostatic mechanisms (human) 
** ROlHL-02212-23 Coagulation of blood (human) 
ROlHL-02254-23 Blood coagulation and hemorrhagic 

disease (human, animals) 
POlHL-06312-17 0030 Surgical cardiology - Total 

artificial heart (calves) 
POlHL-06350-17 0018 Hemostasis research program 

project - Varients of factors IX (human, cattle) 
ROlHL-07835-17 Ejperimental hypertension and renal 

circulation (rats, rabbits) 
ROlHL-09163-13 Control mechanisms in hemostasis 
(human) 
*• ROlHL-10582-12 Thrombosis and hemostasis-Analysis. 

methods and standards (human, cattle, venom) 
** POlHL-11310-12 0103 Mechanisms of cardiovascular 
disease - Heparin-Metabolism and function 
POlHL-11414-11 0033 Thrombosis and atherosclerosis 
program - Human coumarin-induced prothrombin 
** POlHL-11414-11 0035 Thrombosis and atherosclerosis 
program - Mechanism of action of vitamin K (rats) 
ROlHL-1 1880-10 Physiology and pathology of blood 

platelets (human, dogs) 
POlHL-13330-08 0056 Mechanical circulatory support 

Blood compatibility linings (calves) 
ROlHL-13587-06 Synthesis of renin inhibitors and analog 
phosphatides (rats) 



53 



POIHL 13738 08 0002 Ctrdlic aiiiti devices and 

iriltlciil hearts Total replacement with Ktiliclal heart 

(cahres, sheep, ponies) 
POIHL 13738 08 0003 Cardiac assist devices and 

artilicial henrls Pathophysiological ollects ol the artlllclil 

heart (calves) 
ROIHL 13/54 08 Postoperative thromboembolism in 

surgical patients (human) 
P50HI 1418/07 0008 Pulmonary SCOR -Chemical 

mediators in pulmonary vascular responses Pulmonary 

thromboembolism (dogs, human) 
ROIHL 14/39 06 Ihe role ol leukocytes in thrombotic 

disease (human, dogs) 
ROIHL 1484/0/ Mechanism ol action ol vitamin K and 

anticoagulants (rats) 
ROIHL 14992 0/ Mechanism ol thrombin action (human) 
POIHL 15596 05 001/ Coagulation, fibrinolysis, 

hemostasis and hepatitis Heparin and antithrombin III 
ROIHL 1561905 Regulation ol prothrombin synthesis in 

cultured cells (rats) 
ROIHL 15698 12 Factors affecting the action of 

anticoagulants (rats, human) 
ROIHL 15/2806 The carbohydrate of the blood clotting 

glycoproteins (mammals) 
ROIHL 16461 05 Late results of valve replacement 

Computer analysis (human) 
ROIHL 1658205 Artificial lungs (dogs) 
ROIHL 16634 13 Regulation of metabolism in fibroblasts 

and platelets (human, rabbits, sheep) 
ROIHL 1691905 Proteins of blood coagulation (human, 

bovine) 
ROIHL 1695505 Heparin, blood coagulation and lipid 

metabolism (human) 
P60HL1726504 0006 Community blood resource center 

support Research-Evaluation of platelet transfusions 

(human, dog) 
ROlHL-17408-03 Fresh blood rheology-Relation to 

cardiovascular risk (human) 
ROlHL-17479-04 Blood storage-The production of 

cardiotoxic material (dogs, human, swine) 
ROlHL-17513-04 Role of PF-4 in detecting and promoting 

thrombosis (human, primates) 
ROlHL-17726-03 Bacterial heparinasc in diagnostic 

coagulation studies 
ROlHL-17747-04 Endothelial injury and regeneration (rats) 
ROlHL-17752-03 Purified human clotting factor IX- 

Immunologic studies (human) 
ROlHL-17964-04 The alternate pathway for fibrinolysis 

(human) 
' ROlHL-18068-02 Chemistry and activity of homologous 

heparin fractions (rodents) 
' ROlHL-18245-03 Transition state analog inhibitors of 

thrombin (human, cattle) 
POlHL-18576-03 0003 Thrombosis research program 

project - Biocompatible materials 
POlHL-18576-03 0010 Thrombosis research program 

project ■ Evaluation of non-thrombogenic materials (cattle) 
' POlHL-18576-03 0012 Thrombosis research program 

project - Synthetic anticoagulant and thrombolytic agents 

(dogs) 
POlHL-18576-03 0013 Thrombosis research program 

project - Early warning and monitoring test systems in 

thrombotic disease (human) 

Cerebral blood flow after cardiac arrest 



Organization of arterial ground substance 



ROlHL-18590-03 

(dogs, monkeys) 
ROlHL-18625-03 

(cattle) 
ROlHL-18672-03 Dynamic studies of clot structure 

formation (human) 
ROlHL-18738-02 Prevention of postoperative venous 

thrombi (human, cattle) 
ROlHL-18764-03 Biosorbable thromboresistant surfaces 

(dogs, rats, swine, human) 
ROlHL-18815-03 Surgical vascular disorders (human. 

dogs) 
ROlHL-19105-02 Detection and adherence of fibrin 

monomer complexes (human) 
P50HL-191 55-02 0004 Pathophysiology of pulmonary 

edema - Physical and chemical effects of multiple 

pulmonary emboli (sheep) 
ROlHL-19255-03 Evaluation of diagnostic clinical 

hemorrheology (human) 
ROlHL-19322-03 Role of pituitary hormones in the action 

of vitamin K (rats) 
ROlHL-19331-03 Hirudin isolation and utilization (leeches) 
ROlHL-19350-02 Prevention of thrombosis by applied 

electric fields (sheep) 
ROlHL-19772-02 Role of warfarin metabolism in 

antivitamin K activity (rats) 
ROlHL-19820-02 The chemistry and biological effects of 

heparin (Rhesus, human, other mammals) 
ROlHL-20073-02 Blood compatible materials by fluid 

perfusion (human, dogs) 
ROlHL-20577-03 The mechanism of action of vitamin K 
R01HL-2n39-02 Molecular biology of factor XIII (human) 
R23HL-21271-02 Extracorporeal circulation and protein 

denaturation (human) 
ROlHL-21403-02 Blood clotting kinetics studied by 

radioimmunoassay (human) 
ROlHL-214 76 02 Anticoagulant drug absorption 

interactions (rats) 



UlU 

ROIHl 21540 0? Specific inhlbilori of coagulation and 

llbrlnohftit (ratt. rabbit%, do|il 
ROIHI 21544 02 Proteins ol coagulation and Hagenian 

factor pathways (human, goats) 
HOIHI 21548 01 Pathogenesis ol pulmonary 

Ihionibonmtjohc disease (human, mammals) 
ROIHI 2l/(<)0'i Heparin and heparan tullate Slruclurt 

and activity Ibeel. hog) 
" ROIHI 22035 01 Molecular modification ol heparin by 

chemical means (sheep) 
ROIHI 221 19 01 Biochemistry ol platelet function in 

thrombose and cell growth (rabbits) 
•• ROIHI 17ni 01 A new source ol hyaluronidase and 

anticoagulants (leeches) 
ROIHI 22402 01 Heparin biophysical, chemical and 

biological aspects (mice, human) 
ROIHL 22980 01 Kinetic and mechanistic studies ol blood 

coagulation (human, cattle) 
ROIHI 23899 01 Flow and flexing at blood/biomalerial 

interfaces 
** NOIHV 32919 12 Material development and testing 

heparinizalion processes 
NOIHV 72939 01 Develop and evaluate left heart assist 

blood pumps (human, calves, pigs) 

BLOOD COAGULATION, ANTICOAGULANTS, 
PLATELET AGGREGATION INHIBITORS 

POIHL 06350 17 0019 Hemostasis research program 

project Microcirculation (human, rats, rabbits) 
ROIHL 08888 12 Cooperative study of drugs and coronary 

heart disease (men) 
ROIHL 10445 09 Cooperative study of drugs and coronary 

heart disease (men) 
ROIHL 10705 09 Cooperative study of drugs and coronary 

heart disease (men) 
ROIHL 11372-08 Cooperative study ol drugs and coronary 

heart disease (men) 
POlHL-11414 11 0004 Thrombosis and atherosclerosis 

program - Platelet function and nonthrombogenic surfaces 
(human) 
** ROlHL-11775-11 Platelet mechanisms in disease (human, 
primates) 
R01HL-1194510 Synthesis of artificial lung and kidney 

systems (sheep, mice, swine) 
ROIHL 13036-08 Coronary thrombosis -Effects on 
myocardium and in vivo detection (dogs, monkeys) 
ROlHL-13629-08 Hemorrhagic diseases (human) 
P50HL 14147-08 0001 Specialized center of research in 

thrombosis - Role of aspirin, other anti platelet agents in 
platelet lunction (rat, human) 
P50HL-14217-08 0054 Specialized center of research in 

thrombosis - Coagulation section -Platelet aggregation 
(human, pig, rabbit, dog) 
P50HL-14217-08 0055 Specialized center of research in 

thrombosis - Coagulation section-Platelet coagulant activity 
(human) 
" P50HL-14217-08 0058 Specialized center of research in 
thrombosis - Mechanisms of induction and inhibition of 
platelet reaction (human, pig) 
P50HL-14217-08 0062 Specialized center of research in 

thrombosis - Coagulation section -Factor VIII and Factor XII 
(human, cattle) 
P50HL-14230-07 0097 A/S SCOR -Lipids, atherosclerosis 

and thrombosis - Studies of circulating platelet aggregates 
(human) 
** ROlHL-14344-07 Platelet function and adenine nucleotide 
metabolism (human) 
ROlHL-15374-03 Cooperative study of drugs and coronary 

heart disease (human) 
ROlHL-15580-06 Humoral control of pulmonary and 

systemic circulation (animals) 
ROlHL-15593-05 Prolonged extracorporeal cardiopulmonary 

support (rats, sheep, rabbits) 
ROlHL-15681-06 Coronary flow studies of partially 

obstructed vessels (dogs) 
POlHL-16387-04 0005 The blood vessel and 

thrombogenesis - Fluid engineering considerations in 
thrombogenesis 
ROlHL-16582-05 Artificial lungs (dogs) 
" ROlHL-16720-02 Platelet aggregation (human) 

P60HL-1 7265-04 0006 Community blood resource center 

support - Research -Evaluation of platelet transfusions 
(human, dog) 
POlHL-17430-05 0007 Control of coagulation - Platelet 

adhesion, aggregation, ultrastructure in flowing blood 
(human, animals) 
P50HL-17648-04 0023 Study of ischemic heart disease - 

Chemical mediators of inflammation in acute myocardial 
infarction (mammals) 
ROlHL-17747-04 Endothelial injury and regeneration (rats) 
ROlHL-17921-04 Peroxy radicals to prostaglandins in 

vessels and lung 
ROlHL-18288-04 Intraoperative protection of the 

myocardium (dogs, rats) 
R01HL-18502-03 Enzymatic regulation of platelet function 

(human) 
P01HL18576-03 0003 Thrombosis research program 

project - Biocompatible materials 
POlHL-18576-03 0007 Thrombosis research program 

project - Relationships between coagulability and 
thrombosis (human, animals) 
POlHL-18576-03 0010 Thrombosis research program 

project - Evaluation of non-thrombogenic materials (cattle) 

(contd) 



^Excludes routine methodok)gy OR covers onhi general projects which preclude indexing at the specific levet- 
**0neflted significantly to above subject. 



M Grant has subprojects descnbing specihc research aspects 
See Appendix for investigator's name and grant number. 



BLO 

R01HL18644-03 Prosthesis for aortocoronary bypass 

(dogs, baboons) 
** POlHL-18645-03 0006 Biology of the artery wall and 

atherosclerosis - The platelet and atherosclerosis (monkeys, 

baboons) 
ROlHL-18764-03 Biosorbable thromboresistant surfaces 

(dogs, rats, swine, human) 
P01HL18827-02 0003 Platelet vessel wall interactions in 

thrombogenesis - Tumor cell and platelets In 

thrombogenesis and metastasis (human, animals) 
POlHL-1882702 0005 Platelet vessel wall interactions in 

thrombogenesis - Platelet vessel wall interactions in 

thrombogenesis (human) 
P01HL1882702 0006 Platelet vessel wall interactions in 

thrombogenesis ■ Platelet immune injury in man 
P50HL-18828-03 0001 Specialized center of research in 

thrombosis - Membrane biology and hemostasis (human) 
P50HL-18828-03 0005 Specialized center of research in 

thrombosis - Platelet inflammatory factors m thrombosis 

(human, guinea pig) 
** ROlHL-18932-03 Brain microcirculation observed in vivo 

after trauma (mice) 
ROlHL-18937-03 Cyclic nucleotides and calcium in 

platelets (human) 
ROIHL- 1900 1-03 Atherosclerosis in bleeder and drug 

treated subjects (pigs) 
ROlHL-19055-03 Platelet function during extracorporeal 

perfusion (human, mammals) 
** R01HL19n2-03 Atherosclerosis studies (monkeys) 
ROIHL 19278-03 Ristocetin induced platelet aggregation 

(human) 
ROIHL 19996-02 Role of membrane proteins in platelet 

function (human, rabbits) 
** ROlHL-2014002 Glycoproteins of platelet membrane and 

platelet function (human) 
** ROlHL-20251-02 A novel approach to nonthrombogenic 

polymer surfaces (sheep, cattle) 
ROlHL-20313-02 Surface-induced thrombosis-Modification 

of albumin variants (human, goat) 
R23HL-2 1298-02 Coronary vasomotion (dogs, pigs) 
** ROlHL-21533-02 Platelet inhibitor drug in coronary surgery 

(human) 
POlHL-22163-01 0003 Surface thrombogenesis- 

Mechanisms and prevention - In vivo mechanisms of 

biomaterial thrombogenesis and its prevention (baboons) 
** ROlHL-22445-01 Platelet inhibitors-Effect on coronary 

bypass grafts (dogs) 
ROlHL-22527-01 Prostacyclin-thromboxanes In the 

cardiovascular system (human, rabbits) 
POlHL-22602-01 0001 Pathophysiology of the 

endothelium - Platelet-endothelial interactions in vitro 

(human, cattle) 
ROlHL-22612-01 Stabilized prostacyclins to treat vascular 

disease 
" ROlHL-22627-01 An inhibitor of platelet adhesion to 

artificial organs (human) 
** ROlHL-22951-01 Studies on the affect of vitamin E on 

platelets (human, rats) 
ROlHL-231 14-01 Control of platelet aggregation in shock 

(dogs, rabbits) 
ROlHL-23603-01 

disease (rats) 
** NOlHV-42984-05 Interactions of modified biopolymers with 

blood (humans, rats) 
NOlHV-52901-06 Aspirin-myocardial infarction study 
NOlHV-52941-04 Center for aspirin-myocardial infarction 

study (human) 

BLOOD COAGULATION, ANTIFIBRINOLYTIC 
AGENTS 

P50HL-1421708 0049 Specialized center of research in 

thrombosis - Fibrinolysis section -Clinical studies 
POlHL-15596-05 0001 Coagulation, fibrinolysis, 

hemostasis and hepatitis - Defibrination (human) 
P01HL18574-03 0006 Lipoprotein methodology and 

biomedical applications - Lipoprotein transformation, 

lipolytic enzymes, diet and lipid lowering agents 
ROlHL-20846-02 Purification of bovine plasminogen 

proactivator 
ROIHL'2 1540-02 Specific inhibitors of coagulation and 

fibrinolysis (rats, rabbits, dogs) 
ROlHL-22289-01 Endothelial cell mediated fibrinolysis 

(rabbits) 
ROlHL-22573-01 Treatment of post surgical 

vasoconstriction (dogs, monkeys, human, rats) 
ROIHL 22875-01 Crotalase -Chemistry, physiology, clinical 

potential (rats, rabbits) 

BLOOD COAGULATION, ANTITHROMBIN 

SEE ALSO BLOOD COAGULATION, FIBRIN 
SEE ALSO BLOOD COAGULATION, HEPARIN CO-FACTOR 
** R01HL02262 23 Mechanisms regulating plasma proteins 
and solutes (human, dogs) 

R01HL03424-21 Formation and properties of prothrombin 
derivatives (human, animals) 

ROlHL-0436619 Plasminogen -Activation and structure- 
function relations (mammals, birds) 

ROlHL-09739-13 Biophysical studies of proteins (human) 

POlHL'11310-12 0103 Mechanisms of cardiovascular 
disease - Heparin-Metabolism and function 

ROlHL-12820-09 In vitro regulation of prothrombin 
activation 

ROIHL 13160-08 Human thrombin (also cattle) 



Morphogenesis of hypertensive vascular 



54 

** ROlHL-1499207 Mechanism of thrombin action (human) 
** P01HL15596-05 0017 Coagulation, fibrinolysis, 

hemostasis and hepatitis - Heparin and antithrombin III 
ROlHL'15887-05 Enzymes of blood coagulation and 

fibrinolysis (human) 
** R01HL-16238-05 Protein structure in coagulation and 

fibrinolysis (human) 
ROlHL-16355-05 Reactions of thrombin and collagen with 

platelets (human) 
** ROlHL-16919-05 Proteins of blood coagulation (human, 

bovine) 
R01HL-16955-0S Heparin, blood coagulation and lipid 

metabolism (human) 
R01HL17513-04 Role of PF-4 in detecting and promoting 

thrombosis (human, primates) 
POlHL-1781204 0004 Thrombosis and plasma proteins - 

Serum-platelet interaction (human) 
ROlHL-18333-05 Thrombogenesis and hemostatic balance 

(rabbits, human) 
POlHL-18576-03 0011 Thrombosis research program 

project - Proteolysis and platelet function (human, cattle. 

rabbits) 
P50HL-18828-03 0003 Specialized center of research in 

thrombosis - Structure and function of plasma coagulation 

inhibitors (human) 
" ROlHL-19131-04 Hypercoagulability and assays for its 

protection (human) 
** ROlHL-20337-02 Thromboembolic diseases (human) 
** ROlHL-211 13-01 Control mechanisms in coagulation 

(cattle) 
ROlHL-21403-02' Blood clotting kinetics studied by 

radioimmunoassay (human) 
ROlHL-22035-01 Molecular modification of heparin by 

chemical means (sheep) 
ROlHL-221 19-01 Biochemistry of platelet function in 

thrombosis and cell growth (rabbits) 
R01HL-22227-01 A new source of hyaluronidase and 

anticoagulants (leeches) 
ROlHL-22471-01 Biochemistry of prothrombin quick 

(human) 
R23HL-22799-01 Interaction of the complement and 

coagulation systems (monkeys) 
ROlHL-22996-01 Venom proteases-Action on plasma 

protease inhibitors (human) 

BLOOD COAGULATION, ANTITHROMBOGENIC 
SURFACE 

R01HL-0ie48-31 Blood coagulation and hemophilia (dogs. 

swine) 
POlHL-06370-17 0013 Cardiopulmonary and renal 

pathology research center - Morphologic analysis of 

vascular prosthesis (human, dogs) 
ROlHL-10582-12 Thrombosis and hemostasis-Analysis, 

methods and standards (human, cattle, venom) 
** POlHL-11414-11 0004 Thrombosis and atherosclerosis 

program - Platelet function and nonthrombogenic surfaces 

(human) 
ROlHL'11775-11 Platelet mechanisms in disease (human, 

primates) 
ROlHL-1 1945-10 Synthesis of artificial lung and kidney 

systems (sheep, mice, swine) 
M POlHL-13330-08 Mechanical circulatory support 

POlHL-13330-08 0034 Mechanical circulatory support - In 

vivo test and evaluation of left ventricular bypass pumps 

(human, cattle) 
** POlHL-13330-08 0056 Mechanical circulatory support - 

Blood compatibility linings (calves) 
ROlHL-13426-09 Left ventricular bypass for myocardial 

infarction (cattle, human) 
** P01HL13737-07 0002 Assisted circulation - U-shaped 

mechanical auxiliary ventricle (dogs) 
POlHL-13737-07 0032 Assisted circulation - The dynamic 

aortic patch (human, dogs) 
P01HL13738-08 0004 Cardiac assist devices and 

artificial hearts - Hematological evaluation of prosthetic 

materials (calves) 
P50HL-14147-08 0003 Specialized center of research In 

thrombosis - Surface thrombogenicity and phospholipid 

vesicle physical properties 
POlHL-1519604 0002 Program project in biological 

materials - Structural and surface characterization 
POlHL-15195-04 0004 Program project in biological 

materials - Biological evaluation and surface interaction 

studies (dogs) 
ROlHL-15593-05 Prolonged extracorporeal cardiopulmonary 

support (rats, sheep, rabbits) 
ROlHL-15668-06 Extracorporeal respiratory gas exchange- 

A new approach (dogs) 
ROlHL-16921-05 Synthetic hydrogels as blood tolerable 

materials 
P60HL-17269-04 0030 National heart and blood vessel 

research and demonstration center - Cardiovascular 

engineering laboratories (human) 
POlHL-17430-05 0007 Control of coagulation - Platelet 

adhesion, aggregation, ultrastructure in flowing blood 

(human, animals) 
** R01HL17623-05 Initial events in thrombus formation on 

surfaces (human, rats) 
ROlHL-1808403 Artificial heart and related problems 

(calves) 
ROlHL-185 19-03 Albumin, endothelium and 

hemocompatibility (human, dog, cattle, rabbit) 
M P01HL18576-03 Thrombosis research program project 



BLO 

POlHL-18576-03 0003 Thrombosis research program 

project - Biocompatible materials 
POlHL-18576-03 0010 Thrombosis research program 

project - Evaluation of nonthrombogenic materials (cattle) 
ROlHL-18644-03 Prosthesis for aortocoronary bypass 

(dogs, baboons) 
POlHL-1864503 0006 Biology of the artery wall and 

atherosclerosis - The platelet and atherosclerosis (monkeys. 

baboons) 
ROlHL'18764-03 Biosorbable thromboresistant surfaces 

(dogs, rats, swine, human) 
ROlHL-19055-03 Platelet function during extracorporeal 

perfusion (human, mammals) 
ROlHL-19173-03 Analysis of blood trauma from 

microporous oxygenators (human, dogs, rabbits) 
ROlHL-19350-02 Prevention of thrombosis by applied 

electric fields (sheep) 
ROlHL-19419-03 Cellular interactions with foreign 

materials (mammals) 
ROlHL-20073-02 Blood compatible materials by fluid 

perfusion (human, dogs) 
ROlHL-2007902 Thromboresistant material 
ROIHL 20079-02 0001 Thromboresistant material Active 

and passive thromboresistant surfaces 
ROlHL-2007902 0002 Thromboresistant material - 

Thromboresistant materials (sheep) 
ROIHL 20079-02 0003 Thromboresistant material ■ Blood 

surface interactions (human, cattle) 
ROlHL-20251'02 A novel approach to nonthrombogenic 

polymer surfaces (sheep, cattle) 
ROlHL-20313-02 Surface-induced thrombosis-Modification 

of albumin variants (human, goat) 
ROlHL-20356-02 Development and evaluation of an 

artificial heart (calves) 
ROlHL-21001-01 

vascular grafts 
ROlHL-2 11 94-02 



Protein and thrombus deposition on 
Development of antithrombogenic plastic 



'Excludes routine methodotogy OR covers only general projects which preclude indexing 
"Onentwl >if nificantly to above lubject. 



biomaterials 

R23HL-21271-02 Extracorporeal circulation and protein 
denaturation (human) 

R23HL-21805-01 Tissue cell Interactions with vascular 
prostheses (human, rats, mice) 

ROlHL-22 110-02 Healing complications in vascular 
grafting (dogs) 
M POlHL-22163-01 Surface thrombogenesis-Mechanisms and 

prevention 
** POlHL-22163-01 0001 Surface thrombogenesis- 
Mechanisms and prevention - Initial blood protein and 
platelet interactions with biomaterials (baboons) 
** POlHL-22163-01 0002 Surface thrombogenesis- 
Mechanisms and prevention - Laser-scattering detection of 
microemboli in blood flow (baboons) 
** POlHL-22163-01 0003 Surface thrombogenesis- 
Mechanisms and prevention - In vivo mechanisms of 
biomaterial thrombogenesis and its prevention (baboons) 
" POlHL-2216301 9001 Surface thrombogenesis- 
Mechanisms and prevention - Polymers for studing blood- 
material interactions core 

ROlHL-22338-01 Platelet adhesion and aggregation in a 
flow chamber (human) 

R01HL2245501 Platelet concentration in the marginal 
layer (dogs, human) 

ROlHL-22585-01 Plasma proteins adsorbed to artificial 
organs (human, rabbits) 
** ROlHL-22627-01 An inhibitor of platelet adhesion to 

artificial organs (human) 
** ROlHL-23899-01 Flow and flexing at blood/biomaterial 
interfaces 

NOlHV-12060-18 Tissue cultured endothelium for vascular 
prosthetic devices (human, animals) 

NOlHV-32919-12 Material development and testing 
heparinization processes 
" N01HV-3295008 Blood compatible poly-electrolytes 
** NOlHV-32953-10 Materials compatible with blood (dogs) 

NOlHV-32907-04 Interactions of platelets with collagens 
(human, mammals) 

NOlHV-72934-01 Development of a left heart assist blood 
pumps (human, cattle) 

NOlHV-72936-00 Left heart assist device development 
(human, cattle) 

NOlHV-72938-01 Development of a left heart assist blood 
pump 

NOlHV-7293901 Develop and evaluate left heart assist 
blood pumps (human, calves, pigs) 

NOlHV-81388-20 Microfiber substrate for growth of intimal 
linings in circulatory assist devices 

BLOOD COAGULATION, CLOT RETRACTION 

ROlHL-16938-05 Effect of physical forces on blood (dogs, 
human) 
M POlHL-17812-04 Thrombosis and plasma proteins 
** POlHL-17812-04 0004 Thrombosis and plasma proteins - 
Serum-platelet interaction (human) 
POlHL-17812-04 0005 Thrombosis and plasma proteins - 

In vitro systems of normal platelets, white cells, sera 
(human) 
ROlHL-18030-04 The role of contractile proteins in 

platelets (human, rabbits) 
ROlHL-20 106-02 Coupling of platelet contractile proteins 
to fibrin (human) 

(contd) 



at the specific level. 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



BIO 

•LOOO COAGULATION, CLOniNO FACTORS 
(OENEKAl) 

** ROIHI lObS? 12 Thrombojij »nd h«mosl«sis Aimlyjis, 
mtthods and sttndicds (humin. cattlt. venom) 
ROIHL 12820 09 In vilio ra|ul<lion of piolhrombin 
•ctivttion 
•• P50HL 1414/ 08 0018 Specmliigd cenlei ot f«seaich in 
thrombosis Biocbtmical aspects ot platelet function in 
thrombosis and cell iiowth (human) 
PbOHL 1421708 0054 Specialiied center ot research in 

thrombosis Coagulation section Platelet aggregation 
(human, pig. rabbit, dog) 
•* PiOHL 14217 08 OObb Specialiied center ol research in 
thrombosis Coagulation section Platelet coagulant activity 
(human) 
ROIHL 14847 07 Mechanism ot action ot vitamin K and 

anticoagulants (rats) 
ROIHI 14992 07 Mechanism of thrombin action (human) 
•* ROIHL 1572806 The carbohydrate ot the blood clotting 
glycoproteins (mammals) 
P60HL 1599606 0001 Cincinnati comprehensive sickle 

cell center Coagulation mechanisms in sickle cell disease 
(human) 
P60HL 17265 04 0003 Community blood resource center 
support Research Human factor IX-Role in intrinsic 
clotting (also baboons, dogs) 
P60HL 17265 04 0007 Community blood resource center 
support ■ Research Massive transfusion and trauma 
(human) 
" ROIHL 1740204 Mechanism of contact activatron of 

intrinsic clotting (human) 
** ROIHL 1867203 Dynamic studies of clot structure 
formation (human) 
ROIHL 18859-03 Biochemistry ot human (actor XI (human) 
P50HL 19155-02 0004 Pathophysiology of pulmonary 

edema Physical and chemical effects of multiple 
pulmonary emboli (sheep) 
** ROlHL-1927203 Studies on the Passovoy factor (human) 
ROlHL-20313-02 Surface-induced thrombosis -Modification 

of albumin variants (human, goat) 
ROlHL-2100101 Protein and thrombus deposition on 
vascular grafts 
** ROlHL-21543-02 Structure-function relation of blood 

clotting proteins (rabbits) 
** ROIHL 21544-02 Proteins of coagulation and Hageman 

factor pathways (human, goats) 
** ROlHL-21592-01 Lipoproteins and coagulation factors in 

atherosclerosis (pigeons) 
** ROlHL-2253001 Active site studies on blood proteases 
(human) 
ROlHL-23899-01 Flow and flexing at blood/biomaterial 
interfaces 

BLOOD COAGULATION, CRYOFIBRINOGEN 

P50HL-14147-08 0006 Specialized center of research in 

thrombosis - Clearance mechanisms of coagulation 

moieties (human, rabbits, rodents) 
POlHL-17419-04 0001 Studies on mechanisms of 

hemostasis - Structure and metabolism of fibrinogen 

(human) 

BLOOD COAGULATION, FACTOR V 

ROlHL-03424-21 Formation and properties of prothrombin 

derivatives (human, animals) 
R01HL-12820-09 In vitro regulation of prothrombin 
activation 
** POlHL-13108-09 0014 Clinical heart transplantation - 
Platelets and coagulation in accelerated graft coronary 
atherosclerosis 
P50HL-14147-08 0013 Specialized center of research in 
thrombosis ■ Mathematical models of blood coagulation 
kinetics 
** POlHL-15596-05 0018 Coagulation, fibrinolysis. 

hemostasis and hepatitis - Increased plasma lipids on 
blood coagulation and thrombosis (human, animals) 
POlHL-17430-05 0005 Control of coagulation - The 

activation of prothrombin (human, cattle, dogs) 
POIHL 17430-05 0006 Control of coagulation - Activation 
fragments of prothrombin in vitro and in vivo (human, 
dogs, cattle) 
POIHL- 178 12-04 0004 Thrombosis and plasma proteins 

Serum-platelet interaction (human) 
ROlHL-18435-03 Properties of thrombin and Ac-globulin 
(human, animals) 
** POIHL- 1882 7-02 0007 Platelet vessel wall interactions in 
thrombogenesis Biochemistry and role factor V in 
thrombogenesis (human, cattle) 
P50HL- 18828-03 0001 Specialized center of research in 

thrombosis - Membrane biology and hemostasis (human) 
P50HL18828-03 0002 Specialized center of research in 
thrombosis - Endothelial cell biology (human, guinea pig) 
ROIHL 18834-04 Metal-dependent complex formation in 
blood coagulation (human, cattle) 
** ROlHL-18852-03 Biochemical studies on the blood 
coagulation process (human, cattle) 
R01HL-19I31-04 Hypercoagulability and assays for its 

protection (human) 
ROlHL-21403-02 Blood clotting kinetics studied by 

radioimmunoassay (human) 
ROlHL-22471-01 Biochemistry of prothrombin quick 

(human) 
R23HL-22799-01 Interaction of the complement and 
coagulation systems (monkeys) 

•Exdudes routine melhodokigy OR covers onhr general projects which preclude indexing 
Onented significantly to above subject. 



SS 

ROIHL 2287501 Crolalase Chemistry, physiology, cliniial 

potential (rats, rabbits) 
ROIHL 72955 01 metres o( prothrombin activation 

BLOOD COAGULATION, FACTOR VII 

HOIHI 15596 05 0016 Coagulation, fibrinolysis. 

hemostasis and hepatitis Hepatitis B antigen in whole 

blood, plasma and plasma fractions (human, monkeys) 
POIHL 15596 05 001/ Coagulation, fibrinofysis. 

hemostasis and hepatitis Heparin and antilhiombin III 
** POIHL 1559605 0018 Coagulation, fibrinofysis. 

hemostasis and hepatitis Increased plasma lipids on 

blood coagulation and thrombosis (human, animals) 
ROIHL 15728 06 The carbohydrate of the bfood clotting 

glycoproteins (mammals) 
•* ROIHL 1691905 Proteins of blood coagulation (human, 

bovine) 
ROIHL 16955-05 Heparin, blood coagulation and lipid 

metabolism (human) 
" POIHL 1857603 0009 Thrombosis research program 

project Biology of factor VII (human, rabbits, cattle) 
ROIHL 197 72 02 Role of warfarin metaboMsm in 

antivitamin K activity (rats) 
ROIHL 19982 02 Blood coagulation Protern metal ion lipid 

interactions 
•* ROIHL 21 113 01 

(cattle) 
ROIHL 22530-01 

(human) 
R01HL22875-01 Crotalase-Chemistry, physiology, clinrcal 

potential (rats, rabbits) 
** ROlHL-22980-01 Kinetic and mechanistic studies of blood 

coagulation (human, cattle) 

BLOOD COAGULATION, FACTOR VIII 

SEE ALSO BLOOD COAGUUTION DISORDERS, HEMOPHILIA 
" NOlHB-53016-05 Cooperative study of factor VIII inhibitors 

in patients with hemophilia 
** NOlHe-5301804 Cooperative studies of factor VIII 

inhibitors in patients with hemophilia 
** NOlHB-530 19-06 Cooperative study of factor VIII inhibitors 

in patients with hemophilia 
** NOlHB-53020-04 Cooperative study of factor VIII inhibitors 

in patients with hemophilia 
" NOlHB-53021-05 Cooperative study of factor VIII inhibitors 

in patients with hemophilia 
** NOlHB-53023-04 Cooperatrve study of factor VIII inhibitors 

in patients with hemophilia 
** NOlHB-53024-04 Cooperative studies of factor VIII 

inhibrtors in patients with hemophilia 
** NOlHB-53025-05 Cooperative studies of factor VIII 

inhibitors in patients with hemophilia 
" NOlHB-53035-04 Factor VIII inhibitors in patients with 



Control mechanisms in coagulation 
Active site studies on blood proteases 



hemophilia 
ROlHL-01648-31 

swine) 
ROlHL-01661-27 
ROlHL-02254-23 



Blood coagulation and hemophilia (dogs. 



Hemostatic mechanisms (human) 
Blood coagulation and hemorrhagic 
disease (human, animals) 
POlHL-031 74-23 0005 Mechanisms of acute vascular 
reaction to injury - Renal small vessel didease-Cell and 
matrix response (human, mice) 
■ POlHL-06350-17 0005 Hemostasis research program 
project - Purification of plasma antihemophilic factor 
(human) 
POlHL-06350-17 0015 Hemostasis research program 

project • Genetics (human) 
P01HL0635017 0018 Hemostasis research program 

project - Varients of factors IX (human, cattle) 
ROlHL-09163-13 Control mechanisms in hemostasis 

(human) 
ROlHL-09902-13 Comparative study of coagulation and 

vascular disease (animals) 
R01HL-I0582-12 Thrombosis and hemostasls-Analysis, 

methods and standards (human, cattle, venom) 
POlHL-13108-09 0014 Clinical heart transplantation - 
Platelets and coagulation in accelerated graft coronary 
atherosclerosis 
ROIHL- 136 29-08 Hemorrhagic diseases (human) 
P50HL-142 17-08 0055 Specialized center of research in 
thrombosis - Coagulation section-Platelet coagulant activity 
(human) 
P50HL-142 17-08 0058 Specialized center of research in 
thrombosis - Mechanisms of induction and inhibition of 
platelet reaction (human, pig) 
P50HL-14217-08 0062 Specialized center of research in 
thrombosis - Coagulation section-Factor VIII and Factor XII 
(human, cattle) 
P50HL-14230-07 0098 A/S SCOR-Lipids, atherosclerosis 

and thrombosis - Molecular properties of factor VIII (cattle, 
human, mice) 
ROlHL-14595-07 
(human, rats) 
ROlHL-14697-07 Role of platelet membranes in 

hemostasis (human) 
ROlHL-15230-05 Molecular basis of V Willebrand's disease 

and hemophilia (human, cattle) 
ROlHL-15474-06 Structure and function of the 

antihemophilic factor (human, cattle) 
ROlHL-15491-06 Blood coagulation-Platelet-plasma 
protein interaction (human) 



Primary disorders of platelet function 



BIO 

" POIHI 15596 05 0008 Coagulation. ribiinolyiK. 

hemoslitii ind hepatifii Mruclural tludiei and 
froctionalion ol antihemophilic factor (human) 
" P0IHM5596 05 0010 Coagulation. Iibrinolyiit. 

hemostaiis and hepafitli Von Willtbrand t factor (human) 
" POIHI 15596 05 0014 Coagulation, fibrinolysis. 

hemostasis and hepatitis Von Wiflebrand factor and 
platelet retention in glass bead columns (swine) 
•• POIHI 15596 05 0018 Coagulation, fibrinoly.is. 

hemostasis and hepatitis fncreased plasma lipids on 
blood coagulation and thrombosis (human, animals) 
" ROIHI 1561506 Structure function studies of human 

factor VIII/vWF 
•' POIHI 1638/04 0008 The bkwd vessel and 

thrombogenesis Factor VIII m hemostasis (human, 
rabbits) 
•• POIHL 16411 04 0005 Blood systems in coagulation and 

vessel disease Chemical analysis of serum components 
associated with coagulation (human, animal) 
** POIHL 16411 04 0006 Blood systems in coagulation and 

vessel disease Factor VII Immunochemistry and 
immunobiology (human, mice) 
•* ROIHL 16626 05 Studies of antibodies to antihemophilic 

factors (human, rabbits) 
** ROIHL 16872 04 Antihemophilic factor (human) 
*• ROIHL 1691905 Proteins of blood coagulation (human, 

bovine) 
** P60HL 17265 04 0002 Community blood resource center 

support Research Human factor VIM 
P60HL 17265 04 0007 Community blood resource center 

support Research Massive transfusion and trauma 
(human) 
•• POlHL-1 7430-05 0002 Control of coagulation Isolation 

of ristocetin-von Willebrand factor (swine) 
" POIHL 18576 03 0005 Thrombosis research program 
project Molecular basis of von Willebrand's disease and 
hemophilia (human, cattle) 
P50HL 18828-03 0001 Specialized center of research in 

thrombosis Membrane biology and hemostasis (human) 
** P50HL-18828-03 0002 Specialized center of research in 
thrombosis Endothelial cell biology (human, guinea pig) 
ROlHL-18834-04 Metal-dependent complex formation in 

blood coagulation (human, cattle) 
ROlHL-18852-03 Biochemical studies on the blood 

coagulation process (human, cattle) 
ROlHL-19267-02 Serial comparative study of Von 

Willebrand's disease (human) 
ROIHL 1927803 Ristocetin induced platelet aggregation 
(human) 
** ROlHL-20517-03 Diabetes, somatotropin, factor VIII and 

atherosclerosis (human, animal) 
** R23HL-21208-02 Structure-function relationships of human 

factor VIII 
** ROlHL-2 13 79-01 
protein (human) 
ROlHL-21403-02 Blood clotting kinetics studied by 

radioimmunoassay (human) 
ROlHL-21644-01 Fibronectin and related glycoproteins 
(human, rodents) 
•* R23HL-21730-01 vWagll-A new vWD deficient antigen 
(human) 
ROlHL-22266-01 Production of proteases by lung cells in 
culture (human, rodents, rabbits, sheep) 
** ROlHL-22355-01 Purification, structure and function of 
factor VIII (human) 
ROlHL-22471-01 Biochemistry of prothrombin quick 

(human) 
ROlHL-22875-01 Crotalase-Chemistry, physiology, clinical 

potential (rats, rabbits) 
ROlHL-22980-01 Kinetic and mechanistic studies of blood 
coagulation (human, cattle) 

BLOOD COAGULATION, FACTOR IX 

SEE ALSO BLOOD COAGULATIOff DISORDERS, CHRISTMAS 
DISEASE 
ROlHL-02254-23 Blood coagulation and hemorrhagic 

disease (human, animals) 
ROlHL-03424-21 Formation and properties of prothrombin 

derivatives (human, animals) 
** POlHL-06350-17 0018 Hemostasis research program 

project - Varients of factors IX (human, cattle) 
ROlHL-10582-12 Thrombosis and hemostasis-Analysis, 

methods and standards (human, cattle, venom) 
P50HL-14147-08 0017 Specialized center of research in 

thrombosis - Core coagulation laboratory (human) 
ROIHL- 15230-05 Molecular basis of V Willebrand's disease 

and hemophilia (human, cattle) 
POlHL-15596-05 0016 Coagulation, fibrinolysis, 

hemostasis and hepatitis ■ Hepatitis-B antigen in whole 

blood, plasma and plasma fractions (human, monkeys) 
POlHL-15596-05 0017 Coagulation, fibrinolysis, 

hemostasis and hepatitis - Heparin and antithrombin III 
ROlHL-15728-06 The carbohydrate of the blood-clotting 

glycoproteins (mammals) 
POlHL-16387-04 0002 The blood vessel and 

thrombogenesis - Hormonal effects on thrombogenesis 

(rats, rabbits) 
ROlHL-16633-04 Chemistry and biology of factor IX 

activator (human, mice, rats) 
** ROlHL-16919-05 Proteins of blood coagulation (human, 

bovine) 
ROlHL-16955-05 Heparin, blood coagulation and lipid 

metabolism (human) 



Structure of factor Vlll-Von Willebrand 



at the specific level. 



M Grant has subprajects describing specific research aspeds- 
See Appendix for investigator's name and grant number 



(contd) 



BLO 

** P60HL-17265-04 0003 Community blood resource center 
support • Research-Human factor IX-Role in intrinsic 
clotting (also baboons, dogs) 
•* ROlHL-17752-03 Purified human clotting factor IX- 
Immunologic studies (human) 
R01HL18245-03 Transition state analog inhibitors of 
thrombin (human, cattle) 
** POlHL-18576-03 0007 Thrombosis research program 
project - Relationships between coagulability and 
thrombosis (human, animals) 
ROlHL-18834-04 Metal-dependent complex formation in 

blood coagulation (human, cattle) 
RaiHL-19131-04 Hypercoagulability and assays for its 
protection (human) . „ u , 

** R01HL19331-03 Hirudin isolation and utilization (leeches) 
ROlHL-19772-02 Role of warfarin metabolism in 

antiuitamin K activity (rats) 
R01HL-19982-02 Blood coagulation-Protein-metal lon-lipid 

interactions . 

ROlHL-20161-02 Role of gamma-carboxyglutamic acid in 
blood coagulation (human, cattle) 
** ROlHL-2111301 Control mechanisms in coagulation 

(cattle) ^ , , , 

** ROlHL-21975-01 Studies on normal and abnormal tactor 
IX (human, dogs, cows) 
ROlHL-22530-01 Active site studies on blood proteases 

ROlHL-22980-01 Kinetic and mechanistic studies of blooa 
coagulation (human, cattle) 
BLOOD COAGULATION, FACTOR X 

ROlHL-03424-21 (formation and properties of prothrombin 

derivatives (human, animals) 
P01HL0635017 0018 Hemostasis research program 

project • Varients of factors IX (human, cattle) 
ROlHL-10582-12 Thrombosis and hemostasis-Analysis, 

methods and standards (human, cattle, venom) 
R01HL1282009 In vitro regulation of prothrombin 

activation - 

P50HL-14147-08 0003 Specialized center of research in 

thrombosis - Surface thrombogenicity and phospholipid 

vesicle physical properties , 

P50HL-14147-08 0013 Specialized center of research in 

thrombosis - Mathematical models of blood coagulation 

kinetics . 

P50HL-14147-08 0017 Specialized center of research in 

thrombosis ■ Core coagulation laboratory (human) 
P50HL-14217-08 0055 Specialized center of research in 

thrombosis • Coagulation section-Platelet coagulant activity 

R01HTf5230-05 Molecular basis of V Willebrand's disease 

and hemophilia (human, cattle) 
POlHL-15596-05 0014 Coagulation, fibrinolysis, 
hemostasis and hepatitis ■ Von Willebrand factor and 
platelet retention in glass bead columns (swine) 
P01HH5596-05 0016 Coagulation, fibrinolysis, 
hemostasis and hepatitis - Hepatitis-B antigen in whole 
blood plasma and plasma fractions (human, monkeys) 
POlHL-15596-05 0017 Coagulation, fibrinolysis, 

hemostasis and hepatitis ■ Heparin and antithrombin III 
" P01HL15596-05 0018 Coagulation, fibrinolysis, 

hemostasis and hepatitis - Increased plasma lipids on 

blood coagulation and thrombosis (human, animals) 

R01HL15728-06 The carbohydrate of the blood-clotting 

glycoproteins (mammals) 
ROlHL-15887-05 Enzymes of blood coagulation and 

fibrinolysis (human) 
ROlHL-16150-05 Primary structure of prothrombin (canie, 
human) . 

•* ROlHL-16238-05 Protein structure in coagulation and 
fibrinolysis (human) 
POlHL-1641104 0003 Blood systems in coagulation ana 
vessel disease - Molecular events involving the late stages 
of coagulation (rabbits) 
•* ROlHL-16919-05 Proteins of blood coagulation (human, 

bovine) , . j , j 

R01HL16955-05 Heparin, blood coagulation and lipid 

metabolism (human) 
POlHL-1743005 0005 Control of coagulation • The 

activation of prothrombin (human, cattle, dogs) 
P01HL17812-04 0004 Thrombosis and plasma proteins - 

Serum-platelet interaction (human) 
ROlHL-1824503 Transition state analog inhibitors of 

thrombin (human, cattle) 
ROlHL-18333-05 Thrombogenesis and hemostatic balance 

(rabbits, human) 
POlHL-18576-03 0007 Thrombosis research program 

project - Relationships between coagulability and 

thrombosis (human, animals) 
POlHL-18827-02 0007 Platelet vessel wall interactions in 

thrombogenesis - Biochemistry and role factor V m 

thrombogenesis (human, cattle) 
ROlHL-18834-04 Metal-dependent complex formation in 

blood coagulation (human, cattle) 
ROlHL-18852-03 Biochemical studies on the blood 

coagulation process (human, cattle) 
ROlHL-19131-04 Hypercoagulability and assays for its 

protection (human) 
♦• ROlHL-19282-03 Regulation of the activation of human 

factor X /I u \ 

*• ROlHL-19331-03 Hirudin isolation and utilization (leeches) 
ROlHL-19772-02 Role of warfarin metabolism in 
antivitamin K activity (rats) 



56 

ROlHL-19982-02 Blood coagulation-Protein-metal ion-lipid 

interactions 
ROlHL-21113-01 Control mechanisms in coagulation 

(""'^' , ^ A ,, 

ROlHL-21403-02 Blood clotting kinetics studied by 

radioimmunoassay (human) 
ROlHL-21543-02 Structure-function relation of blood 

clotting proteins (rabbits) 
ROlHL-22530-01 

(human) 
ROlHL-22771-01 

(cattle) 
' ROlHL-22955-01 
ROlHL-2298001 



BLO 



Genesis of atherosclerotic lesions 
Microcrystalline and crystalline fibrinogen 



Active site studies on blood proteases 
Thrombogenic phospholipid surfaces 



inetics of prothrombin activation 
Kinetic and mechanistic studies of blood 
coagulation (human, cattle) 
BLOOD COAGULATION, FACTOR XI 

** ROlHL-01661-27 Hemostatic mechanisms (human) 

P50HL-14217-08 0055 Specialized center of research in 

thrombosis - Coagulation section -Platelet coagulant activity 
(human) . 

POlHL-164 11-04 0002 Blood systems in coagulation and 

vessel disease - Early stages of coagulation and 
cardiovascular disease (human, rabbits) 
ROIHL 16633-04 Chemistry and biology of factor IX 
activator (human, mice, rats) 
** ROlHL-16919-05 Proteins of blood coagulation (human, 
bovine) 
R01HL17402-04 Mechanism of contact activation ot 

intrinsic clotting (human) 
P01HL18576-03 0007 Thrombosis research program 
project ■ Relationships between coagulability and 
thrombosis (human, animals) 
ROlHL-18650-03 Platelet collagen interaction (human) 
R01HL18834-04 Metal-dependent complex formation in 
blood coagulation (human, cattle) 
** ROlHL-18859-03 Biochemistry of human factor XI (human) 
R01HL191 31-04 Hypercoagulability and assays for its 

protection (human) 
ROlHL-21544-02 Proteins of coagulation and Hageman 

factor pathways (human, goats) 
ROlHL-21975-01 Studies on normal and abnormal factor 

IX (human, dogs, cows) 
ROlHL-22530-01 Active site studies on blood proteases 

(human) « ui j 

ROlHL-22980-01 Kinetic and mechanistic studies of blood 
coagulation (human, cattle) 
BLOOD COAGULATION, FIBRIN 

ROlHL-01601-30 Blood coagulation and hemorrhagic 

disease (horseshoe crabs) 
ROlHL-01662-25 Equilibria in the fibrinogenfibrin 

conversion (human, cattle) 
ROlHL-022 12-23 Coagulation of blood (human) 
POlHL-0635017 0020 Hemostasis research program 
project - Structure and function of coagulant venom 
proteases . 

** POlHL-06835-17 0028 Cardiovascular disease - Muoies 
in thrombosis-fibrinogen in fibrin transport (human) 
R01HL07379-13 Structure and function of fibrinogen 

(human) « i 

R01HL10582-12 Thrombosis and hemostasis-Analysis. 

methods and standards (human, cattle, venom) 
ROlHL-1 1822-10 Biophysical studies of macromolecular 

interactions (microorganism, human) 
ROlHL-13198-21 Blood coagulation-Physico-chemical 

properties (human, cattle) 
R01HL-13596-07 Clearance of plasma proteins trom 

alveoli , . . 

P50HL-14147-08 0006 Specialized center of research in 
thrombosis • Clearance mechanisms of coagulation 
moieties (human, rabbits, rodents) 
P50HL-14187-07 0008 Pulmonary SCOR-Chemical 

mediators in pulmonary vascular responses - Pulmonary 
thromboembolism (dogs, human) 
P50HL-14217-08 0054 Specialized center of research in 
thrombosis - Coagulation section -Platelet aggregation 
(human, pig. rabbit, dog) 
P50HL-14236-05 0003 Prevention of premature 
arteriosclerosis - Intravascular clotting in patients with 
hyperlipidemia . 

** ROlHL-15226-06 Interaction of blood cells with fibrinogen 

and fibrin (human, animals) 
*• POIHL- 154 86-06 0001 Studies on thrombosis • Studies on 

chemistry of fibrinogen (human, dogs) 
POIHL- 154 86-06 0002 Studies on thrombosis - 

Characterization of antisera to fibrinopeptide B (human, 
rabbits) 
** POlHL-15596-05 0001 Coagulation, fibrinolysis, 
hemostasis and hepatitis ■ Defibrination (human) 
" POlHL-15596-05 0002 Coagulation, fibrinolysis, 

hemostasis and hepatitis ■ Radioimmunoassay of 
fibrinogen and fibrin derivatives (human) 
•* R01HL16361-03 Fibrin complexes in intermediary 
coagulation (human, rabbits) 
POlHL-16411-04 0002 Blood systems in coagulation and 
vessel disease - Early stages of coagulation and 
cardiovascular disease (human, rabbits) 
POlHL-174 19-04 0003 Studies on mechanisms of 

hemostasis • Characterization of fibrinogen (human) 
ROlHL-17964-04 The alternate pathway for fibrinolysis 
(human) 



ROlHL-18473-04 
(human, mules) 

♦ ROlHL-18533-03 

(cattle, bacteria) 

* POlHL-18576-03 0002 Thrombosis research program 

project ■ Molecular basis of fibrin formation (human, cattle, 
lamprey) 
ROlHL-18644-03 Prosthesis for aortocoronary bypass 
(dogs, baboons) 
■* ROlHL-18672-03 Dynamic studies of clot structure 

formation (human) 
•* ROlHL-18935-03 Platelets, fibrinogen, soluble fibnn 

interaction (human) 
'* ROlHL-19105-02 Detection and adherence ot fibrin 
monomer complexes (human) 
R01HL19767-01 Pathochemistry of fibrinogen (humans) 
** ROlHL-20014-02 Radioimmunoassay of hyper and 

hypocoagulable states (rabbits) 
" ROlHL-2010602 Coupling of platelet contractile proteins 

to fibrin (human) 
** ROlHL-20218-02 Fibrinogen catabolism and intravascular 

coagulation (human) 
** ROlHL-20319-02 Assembly, structure and interactions ot 
fibrin (human) 
ROlHL-21001-01 Protein and thrombus deposition on 

vascular grafts . 

P50HL-2 1006-02 0006 Specialized center of research in 
arteriosclerosis - Intravascular coagulation and thrombosis 
in hyperlipidemia (human) 
ROlHL-21548-01 Pathogenesis of pulmonary 
thromboembolic disease (human, mammals) 
ROlHL-2 1644-01 Fibronectin and related glycoproteins 

(human, rodents) 
ROlHL-22505-01 Molecular pathology of fibrinogen and 

factor Xlll (human, animals) 
ROlHL-22955-01 inetics of prothrombin activation 

BLOOD COAGULATION, FIBRIN STABILIZING 
FACTOR 

** ROlHL-02212-23 Coagulation of blood (human) 

POlHL-06835-17 0027 Cardiovascular disease - Studies 

in thrombosis-cross-linking of fibrinogen (human) 
ROlHL-07379-13 Structure and function of fibrinogen 

(human) 
ROlHL-10582-12 Thrombosis and hemostasis-Analysis. 

methods and standards (human, cattle, venom) 
P50HL-14217-08 0048 Specialized center of research in 

thrombosis Fibrinolysis section-Structural studies (human, 

** ROlHL-16346-09 Enzyme assay for blood clotting (human) 
ROlHL-16361-03 Fibrin complexes in intermediary 

coagulation (human, rabbits) 
R01HL-1776903 New methods of studying blood 

coagulation kinetics 
ROlHL-20106-02 Coupling of platelet contractile proteins 

to fibrin (human) 
ROlHL-20319-02 Assembly, structure and interactions ot 
fibrin (human) 
" ROlHL-21 139-02 Molecular biology of factor Xlll (human) 
ROlHL-21644-01 Fibronectin and related glycoproteins 
(human, rodents) 
** ROlHL-22505-01 Molecular pathology of fibrinogen and 

factor Xlll (human, animals) 
BLOOD COAGULATION, FIBRINOGEN 

SEE ALSO BLOOD COAGULATION, CRYOFIBRINOGEN 
SEE ALSO BLOOD COAGUUTION DISORDERS. 

AFIBRINOGENEMIA 
ROlHL-01601-30 Blood coagulation and hemorrhagic 

disease (horseshoe crabs) 
ROlHL-01662-25 Equilibria in the fibrinogenfibrin 
conversion (human, cattle) 
** ROlHL-02262-23 Mechanisms regulating plasma proteins 
and solutes (human, dogs) 
ROlHL-03181-21 0025 Hemodynamics as applied to 

surgical problems • Vascular stenosis (dogs) 
POlHL-06350-17 0020 Hemostasis research program 
project - Structure and function of coagulant venom 
proteases 
** POlHL-06835-17 0027 Cardiovascular disease - Studies 

in thrombosis-cross-linking of fibrinogen (human) 
** POlHL-06835-17 0028 Cardiovascular disease - Studies 

in thrombosis-fibrinogen in fibrin transport (human) 
*• ROlHL-07379-13 Structure and function of fibrinogen 
(human) 
ROlHL-0839915 Platelet injury in infections and allergic 
diseases (human) 
" POlHL-09011-15 0002 A research and resource program 

in blood - Biosynthesis of fibrinogen (dogs) 
ROlHL-10608-12 Digoxin-specific antibodies (human) 
ROlHL-11822-10 Biophysical studies of macromolecular 

interactions (microorganism, human) 
ROlHL-13036-08 Coronary thrombosis-Effects on 
myocardium and in vivo detection (dogs, monkeys) 
ROlHL-13198-21 Blood coagulation-Physico-chemical 

properties (human, cattle) 
ROlHL-13596-07 Clearance of plasma proteins from 
alveoli . 

•* P50HL-14147-08 0006 Specialized center of research in 

thrombosis - Clearance mechanisms of coagulation 
moieties (human, rabbits, rodents) 

(contd) 



•taludes rouline methodok)g, OR covers only general proiects which preclude 
••Oriented significantly to above subject. 



indexing at the specific level. 



M Grant has subpro)ects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



uo 

PSOHl 14147 Oa 0007 Speclalligd ctntor o( resssrch in 
thrombosis Ridioactive ti<c«ts in iBCOgnitian ol 
inttavisrulai coagulition (human. (lo|i>) 
•• P50HL 14? 17 08 0048 SpecialKod cantai ol (oseaich in 

thrombosis fibrinolysis saction Stiucliiral studies (human, 
animal) 
PSOHL 14217 08 0049 Specialirad canter ol research in 

thrombosis fibrinolysis section Clinical studies 
P50MI 1421708 OOiO Specialiied center ol research in 

thrombosis Electron microscopy section (do|sl 
PSOHL 14217 08 00S4 Specialiied center ol research in 
thrombosis Coagulation section Platelet aggregation 
(human, pig, rabbit, dog) 
ROIHL 1499207 Mechanism of thrombin action (human) 
POIHL 1S19S04 0002 Progrnm project in biological 
materials Structural and surlace characteruation 
"• ROIHI 1S226 06 Interaction ot blood cells with fibrinogen 

and libiin (human, animals) 
•* POIHL 1S486 06 0001 Studies on thrombosis Studies on 

chemistry ot librinogen (human, dogs) 
•• P01HL15486 06 0002 Studies on thrombosis 

Characterization ol antisera to librinopeptide B (human, 
rabbits) 
** POIHL 15486 06 0003 Studies on thrombosis 

Mechanism and prevention of librinopeptide B degradation 
(human) 
*' POIHL 15486 06 0004 Studies on thrombosis 

Thrombosis, intravascuair coagulation, platelet aggregation 
(dogs) 
•* P01HL1548606 0006 Studies on thrombosis Clinical 
investigation unit 
ROIHL 1559305 Prolonged extracorporeal cardiopulmonary 
support (rats sheep, rabbits) 
** POIHL 15596-05 0001 Coagulation, fibrinolysis, 
hemostasis and hepatitis Defibrination (human) 
'* P01HL1559605 0002 Coagulation, fibrinolysis, 

hemostasis and hepatitis - Radioimmunoassay of 
fibrinogen and fibrin derivatives (human) 
** P01HL1559605 0003 Coagulation, fibrinolysis, 

hemostasis and hepatitis ■ Plasmin degraded fibrinogen 
fractions (human) 
P01HL1559605 0016 Coagulation, fibrinolysis, 
hemostasis and hepatitis - Hepatitis B antigen in whole 
blood, plasma and plasma fractions (human, monkeys) 
POlHL-15596-05 0017 Coagulation, fibrinolysis, 

hemostasis and hepatitis - Heparin and antithrombin III 
P60HL- 1599606 0001 Cincinnati comprehensive sickle 

cell center - Coagulation mechanisms in sickle cell disease 
(human) 
** R01HL16361-03 Fibrin complexes in intermediary 

coagulation (human, rabbits) 
** P01HL-I641I04 0003 Blood systems in coagulation and 
vessel disease - Molecular events involving the late stages 
of coagulation (rabbits) 
** R01HL1644505 Regulation of plasma protein 

biosynthesis (rats, rabbits) 
'* ROlHL-16646-05 Pathobiology of thromboembolic disorders 
(human) 
P60HL17265 04 0003 Community blood resource center 

support ■ Research-Human factor IX-Role in intrinsic 
clotting (also baboons, dogs) 
M POlHL-17419-04 Studies on mechanisms of hemostasis 
** POlHL-1741904 0001 Studies on mechanisms of 

hemostasis ■ Structure and metabolism of fibrinogen 
(human) 
** POlHL-1 74 19-04 0003 Studies on mechanisms of 

hemostasis - Characterization of fibrinogen (human) 
•* POIHL- 174 19-04 0006 Studies on mechanisms of 

hemostasis - Effect of hormones, drugs and other agents 
on fibrinogen synthesis (chick) 
" POIHL- 174 19-04 0007 Studies on mechanisms of 

hemostasis - Structural analysis of ordered forms of 
fibrinogen (human, cattle) 
ROlHL-17503-03 Vascular bubbles in decompression 

sickness (minipig, dog, goat) 
ROlHL-17623-05 Initial events in thrombus formation on 

surfaces (human, rats) 
POlHL-17812-04 0007 Thrombosis and plasma proteins - 
Blood components-Response to endotoxin (dogs, baboons) 
ROlHL-17930-03 Platelet membrane function-Assessment 

and application (animals) 
ROIHL- 17964-04 The alternate pathway for fibrinolysis 

(human) 
ROlHL-18533-03 Microcrystalline and crystalline fibrinogen 

(cattle, bacteria) 
POlHL-18576-03 0002 Thrombosis research program 
proiect - Molecular basis of fibrin formation (human, cattle, 
lamprey) 
POlHL-18576-03 0007 Thrombosis research program 
project - Relationships between coagulability and 
thrombosis (human, animals) 
* ROIHL 18935-03 Platelets, fibrinogen, soluble fibrin 
interaction (human) 
R01HL-19I05-02 Detection and adherence of fibrin 

monomer complexes (human) 
ROlHL-19173-03 Analysis of blood trauma from 
microporous oxygenators (human, dogs, rabbits) 
ROIHL- 194 1 9-03 Cellular interactions with foreign 

materials (mammals) 
ROlHL-19767-01 Pathochemistry of fibrinogen (humans) 
ROlHL-20014-02 Radioimmunoassay of hyper and 
hypccoagulable states (rabbits) 



57 

ROIHI 20079 02 0003 !hromhorosi%l«nl mnlriinl lllood 

suilace interaclions (human, cattle) 
•• ROlHt 20092 0? Structural and biological propiirtiK% ol 

libiinugen (human, rabbits) 
RUIHt 2021802 fibrinogen catabolism and intravascular 

coagulation (human) 
ROIHI 20313 02 Surface-induced thrombosls-Madilicalion 

ol albumin variants (human, goat) 
ROIHI 20J19 0? Assembly, structure and interactions ol 

fibrin (human) 
ROIHI 21001 01 Protein and thrombus deposition on 

vascular grafts 
P50HL 21006 02 0006 Specialized center ol research in 

arteriosclerosis Intravascular coagulation and thrombosis 

in hyperlipidemia (human) 
R01HL2127302 Fibrinogen labeling with radiometals 
ROIHL 21548 01 Pathogenesis ol pulmonary 

thromboembolic disease (human, mammals) 
POIHL 2?163 01 0001 Surface thrombogenesis 

Mechanisms and prevention Initial blood protein and 

platelet interactions with biomaterials (baboons) 
** ROIHL ??505 01 Molecular pathology of fibrinogen and 

factor XIII (human, animals) 
ROIHL ??87501 Crotalase-Chemistry, physiology, clinical 

potential (rats, rabbits) 
•* N01HV3?917 08 Materials development and testing 

BLOOD COAGULATION, FIBRINOLYSIS 

SEE ALSO BLOOD COAGULATION, PUSMIN 
** R01HL01601 30 Blood coagulation and hemorrhagic 
disease (horseshoe crabs) 
ROIHL 01661-27 Hemostatic mechanisms (human) 
** R01HL02254-23 Blood coagulation and hemorrhagic 

disease (human, animals) 
** ROIHL 04366-19 Plasminogen-Activation and structure- 
function relations (mammals, birds) 
ROlHL-11172-12 Physiology and biochemistry of 

fibrinolytic enzymes (human, animals) 
ROlHL-13423-08 Structure function studies of plasminogen 

and plasmin (human) 
ROlHL-13466-08 Pulmonary platelets in shock, trauma 

and embolization (dogs, pigs, rats) 
P50HL-14147 08 0006 Specialized center of research in 
thrombosis - Clearance mechanisms of coagulation 
moieties (human, rabbits, rodents) 
P50HL-14187-07 0008 Pulmonary SCOR -Chemical 

mediators in pulmonary vascular responses - Pulmonary 
thromboembolism (dogs, human) 
** P50HL-14217-08 0048 Specialized center of research in 

thrombosis - Fibrinolysis section-Structural studies (human, 
animal) 
** P50HL-142 17-08 0049 Specialized center of research in 

thrombosis - Fibrinolysis section -Clinical studies 
P50HL- 142 17-08 0050 Specialized center of research in 

thrombosis - Electron microscopy section (dogs) 
P50HL-142 17-08 0063 Specialized center of research in 

thrombosis - Special clinical studies laboratory 
P60HL-15160-07 0016 Center for sickle cell disease - 

Kinin and plasmin system in sickle cell disease (human) 
ROIHL 15535-06 Structure and function of human plasmin 
M POlHL-15596-05 Coagulation, fibrinolysis, hemostasis and 
hepatitis 
POlHL-15596-05 0002 Coagulation, fibrinolysis, 

hemostasis and hepatitis - Radioimmunoassay of 
fibrinogen and fibrin derivatives (human) 
'* ROlHL-15690-07 Hydrolytic enzymes of blood in health 
and disease (human, animals) 
ROlHL-15817-06 Plasminogen activators from tissues 
(human, pig, cattle) 
** ROlHL-15887-05 Enzymes of blood coagulation and 

fibrinolysis (human) 
** ROlHL-16238-05 Protein structure in coagulation and 
fibrinolysis (human) 
POlHL-164 11-04 0003 Blood systems m coagulation and 

vessel disease - Molecular events involving the late stages 
of coagulation (rabbits) 
ROlHL-16582-05 Artificial lungs (dogs) 
R0IHL-I6642-05 Biochemistry and pathophysiology of 
plasma kallikrein (human, animals) 
** POIHL 17812-04 0002 Thrombosis and plasma proteins ■ 

Activators of fibrinolysis-Synthesis and degradation 
(human, cattle) 
** ROlHL-17964-04 The alternate pathway for fibrinolysis 

(human) 
" POlHL-18576-03 0012 Thrombosis research program 

project - Synthetic anticoagulant and thrombolytic agents 
(dogs) 
ROlHL-186 18-04 Purification and function of human HMW 
kininogen 
** ROlHL-186 72-03 Dynamic studies of clot structure 
formation (human) 
ROlHL-18738-02 Prevention of postoperative venous 

thrombi (human, cattle) 
ROlHL-188 15-03 Surgical vascular disorders (human, 

dogs) 
POlHL-18827-02 0007 Platelet vessel wall interactions in 

thrombogenesis - Biochemistry and role factor V in 
thrombogenesis (human, cattle) 
ROlHL-19131-04 Hypercoagulability and assays for its 

protection (human) 
ROlHL-19287-03 The antihypertensive function of the 
renal medulla (human, rats, rabbits) 



ROIHI 20014 02 Radioimmunoaixy ol hypai and 

hypocoigulable ttitei (rtbbitt) 
KOI HI 20846 0? Purilicitlon ol bovine pltiniino|tn 

proactivator 
ROIHL ?l4r>0 0? Lipoprat«in\, hemotliiii and 

atheroscloroMt (human, rabbil-.) 
** ROlHt 2154002 Sptcilic inhibitori ol coagulalion and 

librinolyMS (rait, Mbhil-,. dogs) 
ROIHI 21544 0? fiu\cin\ ol coagulation and Hageman 

laclor pathways (human, goats) 
ROIHL ? 1548 01 Pathogenesis ol pulmonary 

thromboembolic disease (human, mammals) 
" ROIHL 22289 01 Lndolhelial cell mediated fibrinolysii 

(rabbits) 
ROIHL 22996 01 Venom proteases Action on plaimi 

protease inhibitors (human) 
NOIHV 22917 11 Lipid research clinic (human) 

BLOOD COAGULATION, FIBRINOLYTIC AGENTS 

SfE ALSO BIOOO COAGIJU^TION, LYSOKINASf 
SEE ALSO BIOOD COAGUUTIOf*, PIASMIN 
SEE ALSO BLOOD COAGUUIION, UROKINASE 
SEE ALSO IMMUNOLOGY, ANTIGENS BACTERIAL, 
STREPTOKINASE 
R01HL04366 19 Plasminogen- Activation and structure 

function relations (mammals, birds) 
ROIHL 13036-08 Coronary thrombosis Effects on 
myocardium and in vivo detection (dogs, monkeys) 
ROIHL 1375408 Postoperative thromboembolism in 

surgical patients (human) 
P50HL 1421708 0049 Specialized center of research in 

thrombosis - Fibrinolysis section- Clinical studies 
R01HL-I5593 05 Prolonged extracorporeal cardiopulmonary 

support (rats, sheep, rabbits) 
ROlHL-18672 03 Dynamic studies of clot structure 

formation (human) 
ROIHL 21544 02 Proteins of coagulation and Hageman 

factor pathways (human, goats) 
ROIHL 22227-01 A new source of hyaluronidase and 
anticoagulants (leeches) 

BLOOD COAGULATION, HAGEMAN FACTOR 

ROIHL 01661 27 Hemostatic mechanisms (human) 
POlHL-06350 17 0015 Hemostasis research program 

project - Genetics (human) 
P50HL-14217-08 0055 Specialized center of research in 

thrombosis - Coagulation section-Platelet coagulant activity 

(human) 
** P50HL-14217-08 0062 Specialized center of research in 

thrombosis - Coagulation section -Factor VIII and Factor XII 

(human, cattle) 
P60HL-15160-07 0016 Center for sickle cell disease 

Kinin and plasmin system in sickle cell disease (human) 
POlHL-15195-04 0002 Program project in biological 

materials - Structural and surface characterization 
POlHL-15596-05 0014 Coagulation, fibrinolysis, 

hemostasis and hepatitis - Von Willebrand factor and 

platelet retention in glass bead columns (swine) 
** ROlHL-15690-07 Hydrolytic enzymes of blood in health 

and disease (human, animals) 
ROlHL-16238-05 Protein structure in coagulation and 

fibrinolysis (human) 
** POlHL-16411-04 0002 Blood systems in coagulation and 

vessel disease - Early stages of coagulation and 

cardiovascular disease (human, rabbits) 
" POlHL-16411-04 0005 Blood systems in coagulation and 

vessel disease - Chemical analysis of serum components 

associated with coagulation (human, animal) 
ROlHL-16642-05 Biochemistry and pathophysiology of 

plasma kallikrein (human, animals) 
** ROlHL-16919-05 Proteins of blood coagulation (human, 

bovine) 
ROlHL-17402-04 Mechanism of contact activation of 

intrinsic clotting (human) 
R01HL-I8618-04 Purification and function of human HMW 

kininogen 
M POlHL-18827-02 Platelet vessel wall interactions in 

thrombogenesis 
** POlHL-18827-02 0002 Platelet vessel wall interactions in 

thrombogenesis - Interactions of vessel wall 

macromolecules with factor XII (human, rats) 
P50HL-18828-03 0006 Specialized center of research in 

thrombosis - Etiology and pathogenesis of atherosclerosis 

(rabbit, monkey, rat, human) 
ROlHL-19131-04 Hypercoagulability and assays for its 

protection (human) 
P50HL-19157-02 0008 Studies in cystic fibrosis and 

bronchiolitis - Serum proteins in cystic fibrosis (human) 
ROlHL-20846-02 Purification of bovine plasminogen 

proactivator 
** ROlHL-21544-02 Proteins of coagulation and Hageman 

factor pathways (human, goats) 
ROlHL-22530-01 Active site studies on blood proteases 

(human) 

BLOOD COAGULATION, HEMOSTATICS 

ROlHL-10582-12 Thrombosis and hemostasis-Analysis. 

methods and standards (human, cattle, venom) 
ROlHL-13629-08 Hemorrhagic diseases (human) 
ROlHL-15615-06 Structure-function studies of human 

factor VIII/vWF 
ROlHL-17769-03 New methods of studying blood 

coagulation kinetics 



•Excludes routine methodotogy OR covers only general projects which preclude indexing 
'Onented significantly to above subject 



at the specific level. 



M Grant has subprojects descnbing specific research aspects. 
See Appendix for investigators name and grant number. 



(contd) 



BLO 

*• R01HL1824904 Isolation and identification of platelet 

membrane (human) 
** ROlHL-18333-05 Thrombogenesis and hemostatic balance 
(rabbits, human) 
ROlHL-19278-03 Ristocetin induced platelet aggregation 
(human) 
BLOOD COAGULATION, HEPARIN CO-FACTOR 
P60HLU230-07 0098 A/S SCOR-Lipids, atherosclerosis 
and thrombosis ■ Molecular properties of factor VIII (cattle, 
human, mice) 
ROlHL-1691905 Proteins of blood coagulation (human, 
bovine) 
BLOOD COAGULATION, HIRUDEN 
•* R01HL16238-05 Protein structure in coagulation and 

fibrinolysis (human) 
** ROIHL 1933103 Hirudin isolation and utilization (leeches) 
R01HL20079-02 0003 Thromboresistant material - Blood 
surface interactions (human, cattle) 
BLOOD COAGULATION, LYSOKINASE 
SEE ALSO IMMUNOLOGY, ANTIGENS BACTERIAL, 

STREPTOKINASE 
POlHL-16411-04 0002 Blood systems in coagulation and 
vessel disease • Early stages of coagulation and 
cardiovascular disease (human, rabbits) 
M POlHL-18827-02 Platelet vessel wall interactions in 
thrombogenesis 
POlHL-18827-02 0003 Platelet vessel wall interactions in 
thrombogenesis ■ Tumor cell and platelets in 
thrombogenesis and metastasis (human, animals) 
R23HL-2 11 89-01 Regulation of pulmonary endothelial cell 

activities (human, cattle) 
ROlHL-21548-01 Pathogenesis of pulmonary 
thromboembolic disease (human, mammals) 
ROlHL-22266-01 Production of proteases by lung cells in 

culture (human, rodents, rabbits, sheep) 
R01HL-22289-01 Endothelial cell mediated fibrinolysis 
(rabbits) 
** ROlHL-22939-01 Human kinin and fibrinolytic systems 

and renal disease (human) 
BLOOD COAGULATION, PLASMIN 

SEE ALSO BLOOD COAGULATION, FIBRINOLYTIC AGENTS 
ROlHL-04366-19 Plasminogen -Activation and structure- 
function relations (mammals, birds) 
POlHL-06350-17 0020 Hemostasis research program 
project • Structure and function of coagulant venom 
proteases 
ROlHL-10582-12 Thrombosis and hemostasis-Analysis, 
methods and standards (human, cattle, venom) 
** R01HL11172-12 Physiology and biochemistry of 

fibrinolytic enzymes (human, animals) 
** ROlHL-13423-08 Structure-function studies of plasminogen 
and plasmin (human) 
ROlHL-13596-07 Clearance of plasma proteins from 
alveoli . 

** P50HL-14147-08 0006 Specialized center of research in 
thrombosis - Clearance mechanisms of coagulation 
moieties (human, rabbits, rodents) 
** P60HL1 5160-07 0016 Center for sickle cell disease ■ 
Kinin and plasmin system in sickle cell disease (human) 
POIHLI 5486-06 0001 Studies on thrombosis - Studies on 

chemistry of fibrinogen (human, dogs) 
POIHL- 15486-06 0003 Studies on thrombosis - 
Mechanism and prevention of fibrinopeptide B degradation 
(human) 
** ROlHL-15535-06 Structure and function of human plasmin 
** POlHL-15596-05 0003 Coagulation, fibrinolysis, 

hemostasis and hepatitis - Plasmin degraded fibrinogen 
fractions (human) 
P01HL1559605 0007 Coagulation, fibrinolysis, 
hemostasis and hepatitis - Structural studies and 
fractionation of urokinase (human) 
POlHL-1559605 0019 Coagulation, fibrinolysis, 
hemostasis and hepatitis ■ Protamine assay and serine 
proteases 
R01HL15615-06 Structure function studies of human 

factor VIII/vWF 
ROlHL-15690-07 Hydrolytic enzymes of blood in healtn 

and disease (human, animals) 
R01HL1588705 Enzymes of blood coagulation and 

fibrinolysis (human) 
ROIHL 16361-03 Fibrin complexes in intermediary 

coagulation (human, rabbits) 
P01HL1641104 0002 Blood systems in coagulation and 

vessel disease Early stages of coagulation and 
cardiovascular disease (human, rabbits) 
POlHL-16411-04 0003 Blood systems in coagulation and 

vessel disease ■ Molecular events involving the late stages 
of coagulation (rabbits) 
R01HL16919-05 Proteins of blood coagulation (human, 

bovine) 
P01HL17812-04 0001 Thrombosis and plasma proteins ■ 

Thrombosis and plasma proteins (cattle, guinea pigs) 
R01HL18533-03 Microcrystalline and crystalline fibrinogen 

(cattle, bacteria) 
POlHL-1857603 0005 Thrombosis research program 
project - Molecular basis of von Willebrand's disease and 
hemophilia (human, cattle) 
P01HL18576-03 0012 Thrombosis research program 
project • Synthetic anticoagulant and thrombolytic agents 
(dogs) 



58 

ROlHL-18672-03 Dynamic studies of clot structure 

formation (human) . 

P50HL-1882803 0003 Specialized center of research m 
thrombosis - Structure and function of plasma coagulation 
inhibitors (human) 
R01HL19131-04 Hypercoagulability and assays for its 

protection (human) 
ROlHL-200 14-02 Radioimmunoassay of hyper and 

hypocoagulable states (rabbits) 
ROlHL-20319-02 Assembly, structure and interactions of 

fibrin (human) 
ROlHL-2084602 Purification of bovine plasminogen 

proactivator 
P50HL-2 1006-02 0006 Specialized center of research in 

arteriosclerosis ■ Intravascular coagulation and thrombosis 
in hyperlipidemia (human) 
ROlHL-2154002 Specific inhibitors of coagulation and 

fibrinolysis (rats, rabbits, dogs) 
ROlHL-21544-02 Proteins of coagulation and Hageman 

factor pathways (human, goats) 
ROlHL-22530-01 Active site studies on blood proteases 

(human) 
ROlHL-22996-01 Venom proteases-Action on plasma 
protease inhibitors (human) 
BLOOD COAGULATION, PLASMINOGEN 
** ROlHL-04366-19 Plasminogen-Activation and structure- 
function relations (mammals, birds) 
R01HL10582-12 Thrombosis and hemostasis-Analysis, 
methods and standards (human, cattle, venom) 
** R01HL11172-12 Physiology and biochemistry of 
fibrinolytic enzymes (human, animals) 
ROIHLI 3 160-08 Human thrombin (also cattle) 
** ROlHL-13423-08 Structure-function studies of plasminogen 
and plasmin (human) 
R01HL13466-08 Pulmonary platelets in shock, trauma 

and embolization (dogs, pigs, rats) 
R01HL13596-07 Clearance of plasma proteins from 

alveoli . 

P50HL141 47-08 0006 Specialized center of research in 
thrombosis ■ Clearance mechanisms of coagulation 
moieties (human, rabbits, rodents) 
** ROlHL-15535-06 Structure and function of human plasmin 
** POlHL-15596-05 0007 Coagulation, fibrinolysis, 
hemostasis and hepatitis - Structural studies and 
fractionation of urokinase (human) 
" POlHL-15596-05 0019 Coagulation, fibrinolysis, 

hemostasis and hepatitis - Protamine assay and serine 
proteases 
** ROlHL-15817-06 Plasminogen activators from tissues 
(human, pig, cattle) 
ROlHL-16150-05 Primary structure of prothrombin (came, 
human) . 

** R01HL16238-05 Protein structure in coagulation and 

fibrinolysis (human) 
** P01HL1781204 0001 Thrombosis and plasma proteins 

Thrombosis and plasma proteins (cattle, guinea pigs) 
** POIHL 17812-04 0002 Thrombosis and plasma proteins - 
Activators of fibrinolysis -Synthesis and degradation 
(human, cattle) 
** R01HL1796404 The alternate pathway for fibrinolysis 
(human) . 

P50HL-18828-03 0003 Specialized center of research in 
thrombosis - Structure and function of plasma coagulation 
inhibitors (human) 
** ROlHL-20846-02 Purification of bovine plasminogen 

proactivator . 

** ROlHL-22266-01 Production of proteases by lung cells in 
culture (human, rodents, rabbits, sheep) 
ROlHL-22289-01 Endothelial cell mediated fibrinolysis 

(rabbits) 
ROlHL-22530-01 Active site studies on blood proteases 
(human) 
BLOOD COAGULATION, PLATELET FACTOR III 
P50HL-142 17-08 0055 Specialized center of research in 
thrombosis ■ Coagulation section -Platelet coagulant activity 
(human) , , . 

*♦ POlHL-15486-06 0005 Studies on thrombosis - Isolation 
and characterization of PF4 antigens (rabbits) 
P60HL-15996-06 0001 Cincinnati comprehensive sickle 
cell center - Coagulation mechanisms in sickle cell disease 
(human) 
POlHL-1781204 0004 Thrombosis and plasma proteins - 

Serum-platelet interaction (human) 
POlHL-18576-03 0001 Thrombosis research program 
project ■ Platelet damage from physical forces and 
artificial surfaces (human) 
** ROlHL-203 17-02 Procoagulant lipoproteins -Biochemistry 
and bioactivity (goats, rabbits) 
ROlHL-20411-03 Platelet fatty acid metabolism in 
diabetes (rat, rabbit, guinea pig) 
BLOOD COAGULATION, PROTHROMBIN 
SEE ALSO BLOOD COAGULATION DISORDERS, 

HYPOPROTHROMBINEMIAS 
R01HL01601-30 Blood coagulation and hemorrhagic 
disease (horseshoe crabs) 
** R01HL03424-21 Formation and properties of prothrombin 
derivatives (human, animals) 
P01HL0635017 0018 Hemostasis research program 
project - Varients of factors IX (human, cattle) 



BLO 

R01HL09163-13 Control mechanisms in hemostasis 

(human) 
POlHL-1141411 0033 Thrombosis and atherosclerosis 

program ■ Human coumarininduced prothrombin 
R01HL12820-09 In vitro regulation of prothrombin 

activation 
ROlHL-13160-08 Human thrombin (also cattle) 
R01HL13198-21 Blood coagulation -Physico-chemical 

properties (human, cattle) 
P50HL-14147-08 0003 Specialized center of research in 
thrombosis ■ Surface thrombogenicity and phospholipid 
vesicle physical properties 
P50HL-14147-08 0013 Specialized center of research in 
thrombosis - Mathematical models of blood coagulation 
kinetics , . . 

P50HL-14147-08 0014 Specialized center of research in 
thrombosis Theoretical models for electrostatic effects in 
blood clot formation 
ROlHL-14847-07 Mechanism of action of vitamin K and 

anticoagulants (rats) 
POlHL-15596-05 0016 Coagulation, fibrinolysis, 
hemostasis and hepatitis - Hepatitis-B antigen in whole 
blood plasma and plasma fractions (human, monkeys) 
POlHL-15596-05 0017 Coagulation, fibrinolysis, 
hemostasis and hepatitis - Heparin and antithrombin III 
* POlHL-15596-05 0018 Coagulation, fibrinolysis, 
hemostasis and hepatitis • Increased plasma lipids on 
blood coagulation and thrombosis (human, animals) 
'* R01HL1561905 Regulation of prothrombin synthesis in 

cultured cells (rats) 
■• ROlHL-15728-06 The carbohydrate of the blood-clotting 
glycoproteins (mammals) 
ROlHL-15887-05 Enzymes of blood coagulation and 

fibrinolysis (human) 
ROlHL-15958-06 X-ray diffraction analysis of thrombin 
and neurotoxin 
•• R01HL16150-05 Primary structure of prothrombin (cattle, 

human) 
" ROlHL-1623805 Protein structure in coagulation and 
fibrinolysis (human) 
ROlHL-1663304 Chemistry and biology of factor IX 

activator (human, mice, rats) 
R01HL16919-05 Proteins of blood coagulation (human, 
bovine) . 

•* POlHL-17430-05 0005 Control of coagulation - The 

activation of prothrombin (human, cattle, dogs) 
** POlHL-17430-05 0006 Control of coagulation • Activation 
fragments of prothrombin in vitro and in vivo (human, 
dogs, cattle) . 

** POlHL-17812-04 0004 Thrombosis and plasma proteins - 
Serum-platelet interaction (human) 
ROlHL-18245-03 Transition state analog inhibitors of 

thrombin (human, cattle) 
ROlHL-18435-03 Properties of thrombin and Ac-globulin 

(human, animals) 
P01HL-1857"03 0007 Thrombosis research program 
project ■ i.elationships between coagulability and 
thrombosis (human, animals) 
ROIHL 18834-04 Metal-dependent complex formation in 

blood coagulation (human, cattle) 
ROlHL-18852-03 Biochemical studies on the blood 

coagulation process (human, cattle) 
R01HL19131-04 Hypercoagulability and assays for its 

protection (human) 
ROlHL-19282-03 Regulation of the activation of human 
factor X .t . 

** ROlHL-19322-03 Role of pituitary hormones in the action 
of vitamin K (rats) 
R01HL1977202 Role of warfarin metabolism in 

antivitamin K activity (rats) 
ROlHL-19982-02 Blood coagulation-Protein-metal lon-hpid 
interactions 
** ROlHL-2016102 Role of gamma-carboxyglutamic acid in 

blood coagulation (human, cattle) 
** ROlHL-20577-03 The mechanism of action of vitamin K 
ROlHL-21113-01 Control mechanisms in coagulation 

** ROlHL-2140302 Blood clotting kinetics studied by 

radioimmunoassay (human) 
** ROlHL-21431-02 Factor II antigen and coagulant activity 

(human, animals) 
** R01HL-21543-02 Structure-function relation of blood 

clotting proteins (rabbits) 
** ROlHL-22471-01 Biochemistry of prothrombin quick 

(human) 
ROlHL-22530-01 Active site studies on blood proteases 

(human) 
** ROlHL-2277101 Thrombogenic phospholipid surfaces 

(cattle) , . . 

R23HL-22799-01 Interaction of the complement ana 

coagulation systems (monkeys) 
** ROlHL-22955-01 inetics of prothrombin activation 

BLOOD COAGULATION, THROMBIN 

ROlHL-01601-30 Blood coagulation and hemorrhagic 

disease (horseshoe crabs) 
ROlHL-01662-25 Equilibria in the fibrinogen-fibrin 
conversion (human, cattle) 
** R01HL02212-23 Coagulation of blood (human) 
" R01HL02262-23 Mechanisms regulating plasma proteins 

and solutes (human, dogs) 
** ROlHL-03424-21 Formation and properties of prothrombin 
derivatives (human, animals) 

(contd) 



•Excludes routine methodotogy OR covers only general projects which preclude 
"Oriented significantly to above subject. 



indexing at the specific level. 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



BIO 

P0IH1063I4 17 0054 Immunologic mechanljms in 

Cirdlov«»cul«i diiMs* Phyjiology ol coll communlc^llon^ 
(nilct. Itogs. |uin*i pigs) 
flOlHl'09163 13 Control mechinlsms In hemoslisii 

(humin) 
ROIHI 09/39 13 Biophyjiol studits o( pioleins (humin) 
ROIHI 10b82 12 Thrombosis and h«mo$l«sis Analysis, 

mtthods and standaids (human, cattlt. venom) 
ROIHL 11963 10 Biochomlsti> ot blood vtssel loimjtion 

and disease (swine) 
ROIHL 1282009 In witco regulation o( prottirombin 
activation 
** ROIHL 1316008 Human thrombin (also cattle) 
ROIHL 13198 21 Blood coagulation Physico-chemical 

properties (human, cattle) 
POIHL 13262 O; 0022 Arlerial wall in atherosclerosis 

Mechanisms ot platelet prostaglanoin toimation 
ROIHL 1402006 Characteruation ol myosin Irom blood 

platelets (rabbit) 
P50HI 14147 08 0001 Specialised center ot research in 
thrombosis Role of aspirin, other anti platelet agents in 
platelet function (tat. human) 
P50HL 14147 08 0012 Specialued center ol research in 

thrombosis Tissue culture study of arterial cells (human, 
hamster) 
P50HL 1414708 0013 Specialiied center of research in 
thrombosis • Mathematical models of blood coagulation 
kinetics 
P50H11423007 0095 A/S SCOR Lipids, atherosclerosis 
and thrombosis Blood platelet adherence to endothelial 
smooth muscle cells, fibroblast (human) 
P50HL 14230 07 0096 VS SCORLipids. atherosclerosis 
and thrombosis Ultrastructural studies of endothelial cells 
(human) 
P50HL- 1423007 0098 A/S SCOR-Lipids. atherosclerosis 
and thrombosis - Molecular properties of factor VIII (cattle, 
human, mice) 
ROlHL-14697-07 Role of platelet membranes in 

hemostasis (human) 
ROIHL 14992-07 Mechanism of thrombin action (human) 
ROlHL-15230-05 Molecular basis of V Willebrand's disease 

and hemophilia (human, cattle) 
ROIHL- 15335-06 The nature of the collagen-platelet 

interaction (animals) 
POlHL-15486-06 0003 Studies on thrombosis - 
Mechanism and prevention of fibrinopeptide B degradation 
(human) 
POlHL-15596-05 0017 Coagulation, fibrinolysis. 

hemostasis and hepatitis - Heparin and antifhrombin III 
R01HL-I5616-04 Platelet membrane proteins in 

aggregation (human) 
ROlHL-15887-05 Enzymes of blood coagulation and 
fibrinolysis (human) 
'* ROlHL-15958-06 X-ray diffraction analysis of thrombin 
and neurotoxin 
ROlHL-16150-05 Primary structure of prothrombin (cattle, 

human) 
ROlHL-16238-05 Protein structure in coagulation and 

fibrinolysis (human) 
ROIHL- 16346-09 Enzyme assay for blood clotting (human) 
R01HL-I6355-05 Reactions of thrombin and collagen with 

platelets (human) 
ROlHL-16361-03 Fibrin complexes in intermediary 

coagulation (human, rabbits) 
ROlHL-16633-04 Chemistry and biology of factor IX 

activator (human, mice, rats) 
ROlHL-16634-13 Regulation of metabolism in fibroblasts 
and platelets (human, rabbits, sheep) 
* ROlHL-16720-02 Platelet aggregation (human) 
ROlHL-16872-04 Antihemophilic factor (human) 
ROlHL-16919-05 Proteins of blood coagulation (human, 

bovine) 
R01HL-16955-05 Heparin, blood coagulation and lipid 

metabolism (human) 
POlHL-1743005 0006 Control of coagulation - Activation 
fragments of prothrombin in vitro and in vivo (human, 
dogs, cattle) 
ROlHL-1 751304 Role of PF-4 in detecting and promoting 

thrombosis (human, primates) 
POIHLI 7812-04 0004 Thrombosis and plasma proteins - 

Seromplatelet interaction (human) 
POlHL-17812-04 0005 Thrombosis and plasma proteins ■ 
In vitro systems of normal platelets, white cells, sera 
(human) 
ROIHL- 17930-03 Platelet membrane function-Assessment 

and application (animals) 
ROlHL-18245-03 Transition state analog inhibitors of 

thrombin (human, cattle) 
R01HL-I8435-03 Properties of thrombin and Ac-globulin 

(human, animals) 
POIHL-18576-03 0001 Thrombosis research program 
project - Platelet damage from physical forces and 
artificial surfaces (human) 
POIHL-18576-03 0005 Thrombosis research program 
project ■ Molecular basis of von Willebrands disease and 
hemophilia (human, cattle) 
POlHL-18576-03 0011 Thrombosis research program 

project ■ Proteolysis and platelet function (human, cattle 
rabbits) 
POlHL-1857603 0012 Thrombosis research program 
project - Synthetic anticoagulant and thrombolytic agents 
(dogs) 



I* 

Point 18827 02 000/ Platelet vo^el wall interactions in 

thiombogenesis Biochemistry and role factor V in 
thfombogenesls (human, cattle) 
PbOHl 18H28 03 0003 Specialized center ot research In 

thrombosis Structure and function of plasma coagulation 
inhibitors (human) 
P50HL 1882803 0004 Specialized center ot research in 

thrombosis Membrane changes m platelet physiology Role 
ol complement (mice, human) 
ROIHL 18834 04 Metal dependent complex formation in 

blood coagulation (human, cattle) 
ROIHI 18852 03 Biochemical studies on the blood 

coagulation process (human, cattle) 
ROIHL 18935 03 Platelets, fibrinogen, soluble fibrin 

interaction (human) 
ROIHL 19282 03 Regulation of the activation ot human 

factor X 
ROIHL 19331-03 Hirudin isolation and utilization (leeches) 
ROIHL- 195 14-03 Proteinase Inhibitor model with clinical 

potential 
ROIHL 2007902 0003 Thromboresistant material Blood 

surface interactions (human, cattle) 
ROIHL 205 17 03 Diabetes, somatotropin, factor VIII and 

atherosclerosis (human, animal) 
ROIHL 20971 10 Membrane glycoproteins ol platelets and 

leukocytes (human) 
P50HL-21006-02 0006 Specialized center of research in 
arteriosclerosis - Intravascular coagulation and thrombosis 
in hyperlipidemia (human) 
ROIHL 2111301 Control mechanisms in coagulation 

(cattle) 
R23HI-21208-02 Structure-function relationships of human 

factor VIII 
ROlHL-21403-02 Blood clotting kinetics studied by 

radioimmunoassay (human) 
ROlHL-2 1540-02 Specific inhibitors of coagulation and 

fibrinolysis (rats, rabbits, dogs) 
ROlHL-21548-01 Pathogenesis of pulmonary 
thromboembolic disease (human, mammals) 
ROlHL-21 769-01 Blood compatible benzamidine containing 

polymers 
ROlHL-2250201 Role of phosphoinositides in human 

platelet secretion 
ROlHL-22771-01 Thrombogenic phospholipid surfaces 

(cattle) 
R23HL-22799-01 Interaction of the complement and 

coagulation systems (monkeys) 
ROlHL-22875-01 Crotalase-Chemistry. physiology, clinical 

potential (rats, rabbits) 
ROlHL-22955-01 inetics of prothrombin activation 
BLOOD COAGULATION, THROMBOPLASTIN 
ROlHL-10582-12 Thrombosis and hemostasis-Analysis. 

methods and standards (human, cattle, venom) 
ROlHL-1 1686-09 Dynamics of thrombus formation and 

dissolution (human, chickens) 
ROlHL-13198-21 Blood coagulation -Physico-chemical 

properties (human, cattle) 
ROlHL-14739-06 The role of leukocytes in thrombotic 

disease (human, dogs) 
ROlHL-152 15-06 Role of complement in intravascular 

coagulation (rabbits, mice) 
POlHL-15486-06 0003 Studies on thrombosis - 

Mechanism and prevention of fibrinopeptide B degradation 
(human) 
POlHL-15486-06 0004 Studies on thrombosis - 

Thrombosis, intravascuair coagulation, platelet aggregation 
(dogs) 
POlHL-16411-04 0001 Blood systems in coagulation and 
vessel disease - Molecular studies of the role of 
complement in blood coagulation (human, rabbits) 
POlHL-16411-04 0002 Blood systems in coagulation and 
vessel disease - Early stages of coagulation and 
cardiovascular disease (human, rabbits) 
POlHL-17430-05 0005 Control of coagulation - The 

activation of prothrombin (human, cattle, dogs) 
POlHL-17430-05 0006 Control of coagulation - Activation 

fragments of prothrombin in vitro and in vivo (human, 
dogs, cattle) 
ROlHL-1 7769-03 New methods of studying blood 

coagulation kinetics 
POIHL-18576-03 0007 Thrombosis research program 

project - Relationships between coagulability and 
thrombosis (human, animals) 
** POlHL-18576-03 0009 Thrombosis research program 
project - Biology of factor VII (human, rabbits, cattle) 
ROlHL-203 17-02 Procoagulant lipoproteins-Biochemistry 

and bioactivity (goats, rabbits) 
ROlHL-22980-01 Kinetic and mechanistic studies of blood 
coagulation (human, cattle) 

BLOOD COAGULATION, THROMBOPOIESIS 
INHIBITORS 

ROlHL-022 12-23 Coagulation of blood (human) 
ROlHL-10582-12 Thrombosis and hemostasis-Analysis. 

methods and standards (human, cattle, venom) 
ROlHL-1 1686-09 Dynamics of thrombus formation and 

dissolution (human, chickens) 
ROlHL-11775-11 Platelet mechanisms in disease (human, 

primates) 
ROlHL-14637-05 Thrombopoietin-lmmunoassay and 

characterization (mice) 
ROlHL-14992-07 Mechanism of thrombin action (human) 



•bchides routine melhodotogy OR covers only general projects which preclude indexine 
Onented significantly to above subject. 



BIO 

ROIHI 1588/05 Cniymo ot blood lotiulalion and 

lihrinolysis (human) 
ROIHI 17/69 0] New methods ol studying blood 

roagutation kinclics 
ROIHI 1/964 04 The sHernate pathway tor fibrinolysis 

(human) 
ROIHL 18333 05 Thrombogenesis and hemostatic balance 

(rabbits, human) 
" P50HL 18828 03 0003 Specialized c«nltr ot riMirch in 

thrombosis Structure and function ol plasma coagulation 

inhibitors (human) 
ROlHt 20218 0? Fibrinogen catabolism and intravascular 

coagulation (human) 
ROIHI 21460 0? lipoproleini. hemostasis and 

atherosclerosis (human, rabbits) 
ROIHL 21548 01 Pathogenesis of pulmonary 

thromboembolic disease (human, mammals) 
" NOIHV 5290704 Interactions of platelets with collagent 

(human, mammals) 

BLOOD COAGULATION, THROMBOPOIESIS 
STIMULATING FACTORS 

ROIHL 14637 05 Thrombopoietin Immunoassay and 

characterization (mice) 
ROIHL 15647 06 Hematopoietic studies of cyclic 

hematopoiesis (dogs) 

BLOOD COAGULATION, THROMBOPOIESIS 
STIMULATING FACTORS, THROMBOPOIETIN 

ROIHL 01601 30 Blood coagulation and hemorrhagic 

disease (horseshoe crabs) 
ROIHL 10567 12 Erythropoietin- Immunoassay and 

characterization (dogs) 
ROIHL 14637-05 Thrombopoietin-lmmunoassay and 

characterization (mice) 
ROIHL 15647-06 Hematopoietic studies of cyclic 

hematopoiesis (dogs) 
ROIHL 20826-02 Megakaryocyte proliferation and its 

control (mice) 

BLOOD COAGULATION, THROMBOSTHENIN 

ROIHL 14020-06 Characterization of myosin from blood 

platelets (rabbit) 
ROlHL-l 7769-03 New methods ol studying blood 

coagulation kinetics 
ROIHL 2031902 Assembly, structure and interactions of 

fibrin (human) 

BLOOD COAGULATION, UROKINASE 

ROlHL-04366 19 Plasm inogen-Activation and structure- 
function relations (mammals, birds) 
ROlHL-10582-12 Thrombosis and hemostasis-Analysis. 

methods and standards (human, cattle, venom) 
R01HL-13423-08 Structure-function studies of plasminogen 

and plasmin (human) 
P50HL-14217-08 0049 Specialized center of research in 

thrombosis - Fibrinolysis section-Clinical studies 
P50HL-14217-08 0052 Specialized center of research in 

thrombosis - Radioisotope nuclear medicine section 

(human, dog) 
** POlHL-15596-05 0001 Coagulation, fibrinolysis, 

hemostasis and hepatitis - Defibrination (human) 
" POlHL-15596-05 0007 Coagulation, fibrinolysis, 

hemostasis and hepatitis - Structural studies and 

fractionation of urokinase (human) 
ROlHL-15817-06 Plasminogen activators from tissues 

(human, pig, cattle) 
ROlHL-16150-05 Primary structure of prothrombin (cattle, 

human) 
ROlHL-21540-02 Specific inhibitors of coagulation and 

fibrinolysis (rats, rabbits, dogs) 
ROlHL-22939-01 Human kinin and fibrinolytic systems 

and renal disease (human) 

BLOOD COAGULATION DISORDERS 

SEE ALSO BLOOD AND RE DISORDERS, HEMORRHAGIC 
DISORDERS 

SEE ALSO BLOOD PLATELETS DISORDERS 
ROlHL-02262 23 Mechanisms regulating plasma proteins 

and solutes (human, dogs) 
ROlHL-04366-19 Plasminogen-Activation and structure- 
function relations (mammals, birds) 
** POlHL-06350-17 0015 Hemostasis research program 

project - Genetics (human) 
ROlHL-09163-13 Control mechanisms in hemostasis 

(human) 
R01HL09902-13 Comparative study of coagulation and 

vascular disease (animals) 
ROlHL-11775-11 Platelet mechanisms in disease (human, 

primates) 
R01HL-I1880-10 Physiology and pathology of blood 

platelets (human, dogs) 
P50HL-14147-08 0017 Specialized center of research in 

thrombosis - Core coagulation laboratory (human) 
P50HL-14217-08 0048 Specialized center of research in 

thrombosis - Fibrinolysis section -Structural studies (human, 

animal) 
P50HL-14217-08 0055 Specialized center of research in 

thrombosis ■ Coagulation section-Platelet coagulant activity 

(human) 
ROlHL-15474-06 Structure and function of the 

antihemophilic factor (human, cattle) 
M POlHL-15596-05 Coagulation, fibrinolysis, hemostasis and 

hepatitis 



at the specific level. 



M Grant has subprojects describing specific research aspects 
See Appendix for investigator's name and grant number. 



(contd) 



BIO 



P01HL16411-04 Blood systems in coagulation and vessel 

disease 
R01HL16445-05 Regulation of plasma protein 

biosynthesis (rats, rabbits) 
ROlHL-16919-05 Proteins ot blood coagulation (human, 

bovine) 
P60HL-17265-04 0007 Community blood resource center 
support - Research-Masswe transfusion and trauma 
(human) 
H POlHL-17430-05 Control of coagulation 

ROlHL-17973-04 Cultured aortic endothelial cells (human, 
cattle, dogs, swine) , „ ,, „ 

P01HL-18208-04 0001 Center for the study of blood cell 
rheology ■ Physiological basis of reversible erythrocyte 
shape change (human, firefly) 
** ROlHL-18507-03 Clinical studies of Fletcher factor 
(human) . 

M P01HL1857603 Thrombosis research program proiect 
** ROlHL-18672-03 Dynamic studies of clot structure 

formation (human) 
** R01HL19255-03 Evaluation of diagnostic clinical 
hemorrheology (human) 
RClHL-19272-03 Studies on the Passovoy factor (human) 
ROlHL-19322-03 Role of pituitary hormones in the action 
of vitamin K (rats) 
** ROlHL-20014-02 Radioimmunoassay of hyper and 

hypocoagulable states (rabbits) 
** ROlHL-20092-02 Structural and biological properties ot 

fibrinogen (human, rabbits) 
** ROlHL-21487-01 Molecular characterization of 

Glanzmann's thrombasthenia (human) 
BLOOD COAGULATION DISORDERS, 

AFIBRINOGENEMIA 
** POlHL-15486-06 0003 Studies on thrombosis • 

Mechanism and prevention of fibrinopeptide B degradation 
(human) 
M P01HL17419-04 Studies on mechanisms ot hemostasis 

BLOOD COAGULATION DISORDERS, CHRISTMAS 
DISEASE 

SEE ALSO BLOOD COAGUUTION, FACTOR IX 
** P60HL-1 7265-04 0003 Community blood resource center 
support - Research -Human factor IX -Role in intrinsic 
clotting (also baboons, dogs) 
ROlHL-17752-03 Purified human clotting factor IX - 

Immunologic studies (human) 
ROlHL-20161-02 Role of gamma-carboxyglutamic acid in 

blood coagulation (human, cattle) 
ROlHL-21975-01 Studies on normal and abnormal factor 
IX (human, dogs, cows) 
BLOOD COAGULATION DISORDERS, FACTOR VII 
DEFICIENCY 

ROlHL-09902-13 Comparative study of coagulation and 
vascular disease (animals) 
BLOOD COAGULATION DISORDERS, FACTOR XI 
DEFICIENCY 
POlHL-06350-17 0018 Hemostasis research program 

project - Varients of factors IX (human, cattle) 
ROlHL-09902-13 Comparative study of coagulation and 
vascular disease (animals) 
BLOOD COAGULATION DISORDERS, 
HEMOPHILIA 
SEE ALSO BLOOD COAGULATION, FACTOR VIII 
SEE ALSO BLOOD COAGULATION DISORDERS, CHRlSTfiflAS 

DISEASE 
SEE ALSO BLOOD COAGUUTION DISORDERS, FACTOR XI 

DEFICIENCY 
SEE ALSO BLOOD COAGULATION DISORDERS, VON 

WILLEBRAND'S DISEASE 
NOlHB-53016-05 Cooperative study of factor VIII inhibitors 
in patients with hemophilia 
** NOlHB-53018-04 Cooperative studies of factor Vlll 

inhibitors in patients with hemophilia 

" NOlHB-53019-06 Cooperative study of factor Vlll inhibitors 

in patients with hemophilia ^ i,i.„,c 

" N01HB-53020-04 Cooperative study of factor Vlll inhibitors 

in patients with hemophilia . ki.„,. 

" NOlHB-53021-05 Cooperative study of factor Vlll inhibitors 

in patients with hemophilia 

•♦ NOlHB-5302304 Cooperative study of factor Vlll inhibitors 

in patients with hemophilia 
•• NOlHB-5302404 Cooperative studies of factor Vlll 

inhibitors in patients with hemophilia 
** NOIHB 53025-05 Cooperative studies of factor Vlll 

inhibitors in patients with hemophilia 
*• NOlHB-53035-04 Factor Vlll inhibitors in patients with 
hemophilia , . 

** ROlHL-01648-31 Blood coagulation and hemophilia (dogs, 

swine) 
ROlHL-01661-27 Hemostatic mechanisms (human) 
ROlHL-02254-23 Blood coagulation and hemorrhagic 

disease (human, animals) 
POlHL-0635017 0005 Hemostasis research program 

project Purification of plasma antihemophilic factor 

(human) 
POlHL-06350-17 0015 Hemostasis research program 

project Genetics (human) 
R01HL-09163I3 Control mechanisms in hemostasis 

(human) 



60 

ROlHL-09902-13 Comparative study of coagulation and 

vascular disease (animals) 
ROlHL-1058212 Thrombosis and hemostasis-Analysis, 

methods and standards (human, cattle, venom) 
ROlHL-13629-08 Hemorrhagic diseases (human) 
' R01HL15230-05 Molecular basis of V Willebrand's disease 

and hemophilia (human, cattle) 
ROlHL-1547406 Structure and function of the 

antihemophilic factor (human, cattle) 
ROlHL-15491-06 Blood coagulation-Platelet-plasma 

protein interaction (human) 

* P01HL15596-05 0008 Coagulation, fibrinolysis, 

hemostasis and hepatitis ■ Structural studies and 
fractionation of antihemophilic factor (human) 

* P01HL1641104 0006 Blood systems in coagulation and 

vessel disease ■ Factor Vll-lmmunochemistry and 
immunobiology (human, mice) 
ROlHL-16626-05 Studies of antibodies to antihemophilic 
factors (human, rabbits) 
■* R01HL1687204 Antihemophilic factor (human) 
'* P60HL-17265-04 0001 Community blood resource center 

support - Demonstration and evaluation 
" P60HL-17265-04 0002 Community blood resource center 
support - Research -Human factor Vlll 
P60HL-17265-04 0003 Community blood resource center 

support - Research -Human factor IX-Role in intrinsic 
clotting (also baboons, dogs) 
R01HL1746203 Role of glycosphingolipids in platelet 

aggregation (rats, human, dogs) 
P01HL17812-04 0002 Thrombosis and plasma proteins • 
Activators of fibrinolysis-Synthesis and degradation 
(human, cattle) 
** POlHL-18576-03 0005 Thrombosis research program 

project - Molecular basis of von W/illebrand's disease and 
hemophilia (human, cattle) 
POlHL-18576-03 0007 Thrombosis research program 
project Relationships between coagulability and 
thrombosis (human, animals) 
POlHL-18576-03 0009 Thrombosis research program 

project - Biology of factor VII (human, rabbits, cattle) 
ROlHL-21379-01 Structure of factor VlllVon Willebrand 
protein (human) j , » » 

** ROlHL-223 55-01 Purification, structure and function ot 

factor Vlll (human) 
BLOOD COAGULATION DISORDERS, 

HYPOPROTHROMBINEMIAS 
** ROlHL-2247101 Biochemistry of prothrombin quick 

(human) 
BLOOD COAGULATION DISORDERS, 
INTRAVASCULAR COAGULATION 
DISSEMINATED 
SEE ALSO HEMOPROTEINS, HEMOGLOBINOPATHIES, SICKLE 

CELL CRISIS 
ROlHL-01601-30 Blood coagulation and hemorrhagic 

disease (horseshoe crabs) 
ROlHL-02254-23 Blood coagulation and hemorrhagic 
disease (human, animals) 
" POlHL-063 14-17 0047 Immunologic mechanisms in 

cardiovascular disease - Role of intravascular coagulation 
(human, animals) 
** POlHL-06835-17 0027 Cardiovascular disease ■ Studies 

in thrombosis-cross-linking of fibrinogen (human) 
" POlHL-06835-17 0028 Cardiovascular disease ■ Studies 
in thrombosis-fibrinogen in fibrin transport (human) 
P01HL10342-13 0028 The integrated function of 
respiration and circulation - Mediator release, 
hemodynamics and respiratory function in anaphylaxis 

(dogs) ■ « 1 ■ 

ROIHL 10582-12 Thrombosis and hemostasis-flnalysis, 

methods and standards (human, cattle, venom) 
ROlHL-10608-12 Digoxin-specific antibodies (human) 
** POlHL-11310-12 0095 Mechanisms of cardiovascular 
disease - Blood and transfusion disorders (human, rats, 
monkeys) ^ . j 

ROlHL-1 1686-09 Dynamics of thrombus formation and 
dissolution (human, chickens) 
** ROlHL-1346608 Pulmonary platelets in shock, trauma 
and embolization (dogs, pigs, rats) 
POlHL-13738-08 0002 Cardiac assist devices and 
artificial hearts ■ Total replacement with artificial heart 
(calves, sheep, ponies) 
" P01HL13738-08 0003 Cardiac assist devices and 

artificial hearts - Pathophysiological effects of the artificial 
heart (calves) 
M P50HL1414708 Specialized center of research in 

thrombosis . 

P50HL-1414708 0006 Specialized center of research in 

thrombosis - Clearance mechanisms of coagulation 

moieties (human, rabbits, rodents) 
** P50HL-14147-08 0007 Specialized center of research in 

thrombosis - Radioactive tracers in recognition of 

intravascular coagulation (human, dogs) 
" P50HL-14236-05 0003 Prevention of premature 

arteriosclerosis - Intravascular clotting in patients with 

hyperlipidemia 
** ROlHL-1473906 The role of leukocytes m thrombotic 

disease (human, dogs) 
** ROlHL-15215-06 Role of complement in intravascular 

coagulation (rabbits, mice) 
M POlHL-15486-06 Studies on thrombosis 



M 



BLO 

POlHL-15486-06 0003 Studies on thrombosis ■ 
Mechanism and prevention of fibrinopeptide B degradation 
(human) 

POlHL-15486-06 0004 Studies on thrombosis - 

Thrombosis, intravascuair coagulation, platelet aggregation 

POIHL- 15486-06 0005 Studies on thrombosis - Isolation 

and characterization of PF4 antigens (rabbits) 
P01HL1559605 0001 Coagulation, fibrinolysis, 

hemostasis and hepatitis ■ Defibrination (human) 
POlHL-15596-05 0002 Coagulation, fibrinolysis, 
hemostasis and hepatitis - Radioimmunoassay of 
fibrinogen and fibrin derivatives (human) 
ROlHL-1625405 Pathogenesis of bubble and clot 

formation (fish) 
ROlHL-16361-03 Fibrin complexes in intermediary 
coagulation (human, rabbits) 
■ P01HL1641104 0001 Blood systems in coagulation and 
vessel disease - Molecular studies of the role of 
complement in blood coagulation (human, rabbits) 
' POlHL-1641104 0002 Blood systems in coagulation and 
vessel disease • Early stages of coagulation and 
cardiovascular disease (human, rabbits) 
* POlHL-16411-04 0004 Blood systems in coagulation and 
vessel disease - Platelets reactions in vascular injury 
(human, animals) 
R01HL16603-05 Human and experimental renal diseases 

(animals) . 

R01HL16634-13 Regulation of metabolism in fibroblasts 

and platelets (human, rabbits, sheep) 
ROlHL-16646-05 Pathobiology of thromboembolic disorders ^ 

(human) 
P01HL17419-04 Studies on mechanisms ot hemostasis 
P01HL17419-04 0001 Studies on mechanisms of 

hemostasis • Structure and metabolism of fibrinogen 
(human) 
POlHL-17430-05 0005 Control of coagulation • Ihe 

activation of prothrombin (human, cattle, dogs) 
POlHL-17430-05 0006 Control of coagulation - Activationl 
fragments of prothrombin in vitro and in vivo (human, 
dogs, cattle) • , . .v 

ROlHL-17752-03 Purified human clotting factor IX - 

Immunologic studies (human) 
P01HL1857603 0007 Thrombosis research program 

project - Relationships between coagulability and 
thrombosis (human, animals) 
POlHL-1857603 0009 Thrombosis research program 
project - Biology of factor VII (human, rabbits, cattle) 
P01HL18576-03 0012 Thrombosis research program 
project ■ Synthetic anticoagulant and thrombolytic agents 
(dogs) 
POlHL-18827-02 Platelet vessel wall interactions in 

thrombogenesis 
■* POlHL-18827-02 0003 Platelet vessel wall interactions in 
thrombogenesis - Tumor cell and platelets in 
thrombogenesis and metastasis (human, animals) 
•* P01HL18827-02 0007 Platelet vessel wall interactions in 
thrombogenesis - Biochemistiy and role factor V in 
thrombogenesis (human, cattle) 
R01HL19105-02 Detection and adherence of fibrin 

monomer complexes (human) 
ROlHL-19270-03 Effects of erythropoiesis on platelets ana 
hemostasis (rats) 
** ROlHL-20014-02 Radioimmunoassay of hyper and 

hypocoagulable states (rabbits) 
** ROlHL-20218-02 Fibrinogen catabolism and intravascular 

coagulation (human) . 

** P50HL-21006-02 0006 Specialized center of research in 
arteriosclerosis - Intravascular coagulation and thrombosis 
in hyperlipidemia (human) 
R01HL-2U31-02 Factor II antigen and coagulant activity 

(human, animals) 
ROlHL-2 1460-02 Lipoproteins, hemostasis and 

atherosclerosis (human, rabbits) 
ROlHL-21548-01 Pathogenesis of pulmonary 
thromboembolic disease (human, mammals) 
BLOOD COAGULATION DISORDERS, VON 
WILLEBRAND'S DISEASE 
SEE ALSO BLOOD COAGULATION, FACTOR Vlll 
ROlHL-01601-30 Blood coagulation and hemorrhagic 
disease (horseshoe crabs) 
" ROlHL-01648-31 Blood coagulation and hemophilia (dogs. 
swine) . 

ROlHL-01661-27 Hemostatic mechanisms (human) 
ROlHL-02254 23 Blood coagulation and hemorrhagic 

disease (human, animals) 
POlHL-0635017 0005 Hemostasis research program 

proiect ■ Purification of plasma antihemophilic factor 
(human) 
P01HL06350-17 0015 Hemostasis research program 

project • Genetics (human) 
ROlHL-09902-13 Comparative study of coagulation and 

vascular disease (animals) 
P50HL-14217-08 0055 Specialized center of research in 

thrombosis ■ Coagulation section-Platelet coagulant activit 
(human) . 

P50HL-14217-08 0058 Specialized center of research in 

thrombosis - Mechanisms of induction and inhibition of 
platelet reaction (human, pig) 
ROlHL-14595-07 Primary disorders of platelet function 

(human, rats) 

(contd) 



M 



•Excludes routine melhodokigy OR covers only general projects which preclude 
••OrieiTted significantly to above subject 



indexing at the specific level. 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigators name and grant number. 



■lO 



■ R0IHU!>230 0i Moltculii bull Of V Wlllabiand'] dUease 

•nd htmophilit (human, cattle) 

■ POIHI lbS96 0b 0008 Coatulation, tibiinolysiv 

hamostasis and hapatitis Sttuctuial sludias and 

Itactionatlon of antihtmophllic tactoi (human) 
' POIHL lii96 0b 0010 Coaiulalion, (ibiinolysis. 

hamostasis and hepatitis Von Willebiand's lactoi (human) 
' POIHI 15596 05 0014 Coatulation. (ibrinolysiv 

hamostasis and hepatitis Von Willebiand tacloi and 

platelet letention in (lass bead columns (swine) 
POIHL 1638; 04 0005 The blood vessel and 

thrombogenesis - fluid snilneetini consideiations in 

thrombogenesis 
POIHL 1638; 04 0008 The blood vessel and 

thrombogenesis Factor VIII in hamostasis (human, 

rabbits) 
POIHL 1641104 0006 Blood systems in coagulation and 

vessel disease Factor VII Immunochemistry and 

immunobiology (human, mice) 
ROIHL 16626 05 Studies ot antibodies to antihemophilic 

factors (human, rabbits) 
ROIHL 16872 04 Antihemophilic factor (human) 
P60HI 1726504 0002 Community blood resource center 

support Research Human factor VIII 
P01HL1743005 0001 Control of coagulation Porcine 

von Willebrand's disease 
POIHL 17430 05 0002 Control of coagulation Isolation 

of ristocetin- von Willebrand factor (swine) 
POIHL 1743005 0008 Control of coagulation ■ Cultures 

of von Willebrand endothelial cells (pigs) 
ROIHL 1797304 Cultured aortic endothelial cells (human, 

cattle, dogs, swine) 
POIHL 18576-03 0005 Thrombosis research program 

project Molecular basis of von Willebrand's disease and 

hemophilia (human, cattle) 
P50HL 18828-03 0002 Specialized center of research In 

thrombosis ■ Endothelial cell biology (human, guinea pig) 
ROlHL-19001-03 Atherosclerosis in bleeder and drug 

treated subjects (pigs) 
ROlHL-19267-02 Serial comparative study of Von 

Willebrand's disease (human) 
ROlHL-20924-02 Atherosclerosis and arterial cell functions 

(human, rabbits) 
R23HL-21208-02 

factor VIII 
ROlHL-21379-01 

protein (human) 
R23HL-2 1730-01 
(human) 



Structure-function relationships of human 
Structure of factor Vlll-Von Willebrand 
vWagll-A new vWD deficient antigen 



granulocytes 
NOlHB-62973-05 

granulocytes 
ROlHL-05351-18 



BLOOD COAGULATION TESTS* 

SEE ALSO BLOOD COAGUUTION, CLOT RETRACTION 
** NOlHB-53020-04 Cooperative study of factor VIII inhibitors 

in patients with hemophilia 
ROlHL-02212-23 Coagulation of blood (human) 
ROlHL-10582-12 Thrombosis and hemostasis-Analysis, 

methods and standards (human, cattle, venom) 
P50HL-14217-08 0063 Specialized center of research in 

thrombosis - Special clinical studies laboratory 
** POlHL-15596-05 0019 Coagulation, fibrinolysis, 

hamostasis and hepatitis - Protamine assay and serine 

proteases 
" R01HL-I6346-09 Enzyme assay for blood clotting (human) 
P01HL-17430-05 0001 Control of coagulation - Porcine 

von Willebrand's disease 
POlHL-17430-05 0002 Control of coagulation - Isolation 

of ristocetin-von Willebrand factor (swine) 
** ROlHL-1 7726-03 Bacterial heparinase in diagnostic 

coagulation studies 
P01HL18576-03 0013 Thrombosis research program 

project ■ Early warning and monitoring test systems in 

thrombotic disease (human) 
R01HL18618-04 Purification and function of human HII/IW 

kininogen 
** ROlHL-19105-02 Detection and adherence of fibrin 

monomer complexes (human) 
ROlHL-21487-01 Molecular characterization of 

Glanzmann's thrombasthenia (human) 
N01HV-22917-U Lipid research clinic (human) 

BLOOD COAGULATION TESTS, PROTHROMBIN 
TIME* 

ROIHL- 15840-02 Sugar-induced heart lesions and vitamin 
K deficiency (birds, mammals subhuman) 

BLOOD COAGULATION TESTS, THROMBIC 
INDEX* 

NOlHV-42961-06 Evaluation of biomaterials in contact 
with blood (dogs) 
** NOlHV-42969-06 Interactions of natural and chemically 
modified biopolymers with blood (dogs) 
NO lHV-629 11-04 Vena cava ring tests of biomaterials in 
dogs 

BLOOD DISORDERS (GENERAL) 

SEE BLOOD AND RE DISORDERS. BLOOD DISORDERS 
(GENERAL) 

BLOOD DISORDERS CONGENITAL (HEREDITARY) 

SEE BLOOD AND RE DISORDERS CONGENITAL (HEREDITARY) 
BLOOD DONORS 

SEE BLOOD TRANSFUSION. BLOOD DONORS 

^Excludes routine methodology OR covers onhi general projects which preclude indexing at the specific level 
Onented significanthr to above subject. 



61 

BLOOD FILTERS 

Sll moon IHIAIMfNI, BIOOO IIIIFRS 
BLOOD FLOW 

SF( CAROIOVASCIIIAR fllNCllON. HI OOD (lOW 
BLOOD FLOW IMPEDANCE 

Sff CARDIOVASCUIAR FUNCTION. BIOOD FlOW IMPfOANCF 
BLOOD FLOW MEASUREMENTS 

SFF CARDIOVASCUIAR DISORDFRS DIAGNOSIS, BLOOD FLOW 
MFASURFMFNIS* 

BLOOD Flow OSCILLATORY 

SEE CARDIOVASCUUR FUNCTION, BLOOD FLOW 
OSCILLATORY 

BLOOD FLOWMETERS 

SFF CARDIOVASCUIAR DISORDERS DIAGNOSIS, BLOOD FLOW 
MFASUREMFNTS* 

BLOOD FRACTIONATION 

SEE BLOOD AND RE SYSTEM. BLOOD FRACTIONATION 
BLOOD GROUP ANTIGENS 

SEE BLOOD GROUPS ANTIGENS 
BLOOD GROUP INCOMPATIBILITY 

SEE ALSO BLOOD GROUPS 
SEE ALSO BLOOD TRANSFUSION 
ROIHL 10036 13 Biology of red cell antigen-antibody 
reaction (human) 

BLOOD GROUP INCOMPATIBILITY PERINATAL, 
ABO HEMOLYTIC DISEASE NEWBORN 

SEE ALSO BLOOD GROUPS. ABO (H) SYSTEM 
ROlHL-05351-18 Blood group antigens and antibodies 
(human, rabbits, sheep) 

BLOOD GROUP ISOANTIBODIES 

SEE BLOOO GROUPS ISOANTIBODIES 
BLOOD GROUP ISOANTIGENS 

SEE BLOOD GROUPS ANTIGENS 
BLOOD GROUPS 

SEE ALSO TISSUE COMPATIBILITY-TRANSPLANT. 
HISTOCOMPATIBILITY TYPING 
POlHL-031 74-23 0006 Mechanisms of acute vascular 

reaction to injury - Atherosclerotic plaque studies using 
mosaic analysis (human) 
** R01HL05351-18 Blood group antigens and antibodies 

(human, rabbits, sheep) 
** POlHL-09011-15 0001 A research and resource program 

in blood - Genetic markers of human blood and gene 
mapping (human) 
** POlHL-09011-15 0012 A research and resource program 
in blood - Theoretical population genetics (human) 

Molecular pathology of genetic disorders 



Genetics of glycosyltransferases in 
Pathogenesis of pulmonary 



ROlHL-1512507 

in man 
** ROlHL-20301-02 

human blood 
ROlHL-21548-01 

thromboembolic disease (human, mammals) 

BLOOD GROUPS, ABO (H) SYSTEM 

SEE ALSO BLOOO GROUP INCOMPATIBILITY PERINATAL. ABO 

HEMOLYTIC DISEASE NEWBORN 
SEE ALSO IMMUNOLOGY. SECRETORY (ANTIBODY) (FACTOR) 

SYSTEM 
NOlHB-62970-02 Collection, function and transfusion of 



Collection, function and transfusion of 



Blood group antigens and antibodies 
(human, rabbits, sheep) 
ROlHL-151 25-07 Molecular pathology of genetic disorders 
in man 
** R01HL17881-15 Biosynthesis and degradation of blood 
group substances (human, animals) 
ROlHL-20301-02 Genetics of glycosyltransferases in 
human blood 

BLOOD GROUPS, BOMBAY 

R01HL-2030I 02 Genetics of glycosyltransferases in 
human blood 

BLOOD GROUPS, MNSS SYSTEM 

ROlHL-05351-18 Blood group antigens and antibodies 

(human, rabbits, sheep) 
R01HL-2030102 Genetics of glycosyltransferases in 

human blood 

BLOOD GROUPS, RH SYSTEM 

SEE ALSO BLOOD GROUPS ISOANTIBODIES, RH ANTIBODIES 



ROlHL-12994-09 
R01HL-23I08-01 

(human) 
ROlHL-2402102 

activity (human) 



The Rh complex of red cells (human) 
Membrane biochemistry of RH antigens 

Erythocyte membrane sulfhydrls and Rh 



BLOOO GROUPS ANTIGENS 

SEE ALSO BLOOD GROUPS 
SEE ALSO TISSUE COMPATIBILITY-TRANSPLANT, 
ISOALLOANTIGENS 
ROlHL-05351-18 Blood group antigens and antibodies 
(human, rabbits, sheep) 



M Grant has subprojects descnbing specific research aspects 
See Appendix for investigator's name and grant number. 



POIHI 09011 15 0001 A research and rtuurci program 

in blood Genetic marheii of human blood and |gn« 

mapping (human) 
ROIHL 10036 I'l Biology of red cell *nti|tn antibody 

reaction (human) 
" ROIHI lll')4 12 Bk)Od group antigent and antibodi*! 

(human) 
POIHI 1215/ II 0033 Functions and mcchanismi of call 

membrane ion transport Immunology aip«cti of active 

Na K transport in sheep red cell (alto human, mice) 
•• ROIHI 12994 09 The Rh complex of rod cells (human) 
ROIHI I4H44 06 Mufou-, glycoprotein in human reipiritory 

epithelium (also whr^al) 
POIHI 15486 06 0005 Studies on thrombosis Isolation 

and characterization of PF4 antigens (rabbits) 
ROIHL 16774 04 Genetic epidemiology of hyperlipemia 

(Honolulu) 
PGOHL 1/265 04 0008 Community blood resource center 

support Research Blood genetic markers as biological 

probes (human) 

BLOOD GROUPS ANTIGENS, II ANTIGENS 

** R23HL 21328 02 The I blood group antigen of human 
erythrocyte membrane 

BLOOD GROUPS ISOANTIBODIES 

SEE ALSO TISSUE COMPATIBILITY TRANSPLANT. 
ISOALLOANTIBODIES 
ROIHL 08696 15 0011 Orthotopic heart transplantation 
Transplantation immunology-lmmunodepressive factor 
(human, dogs) 
*• ROIHL 11154 12 Blood group antigens and antibodies 
(human) 
P6QHL 1726504 0008 Community blood resource center 

support Research- Blood genetic markers as biological 
probes (human) 

BLOOD GROUPS ISOANTIBODIES, RH 
ANTIBODIES 

ROIHL 05351-18 Blood group antigens and antibodies 
(human, rabbits, sheep) 

BLOOD LIPIDS 

SEE LIPIDS BLOOD 

BLOOD LIPOPROTEIN DISORDERS 

SEE LIPOPROTEINS BLOOD. DYSLIPOPROTEINEMIAS 
BLOOD OSMOTIC PRESSURE 

POIHL 11678-11 0020 Cardiovascular dynamics and their 

control ■ Circulatory and pulmonary fluid dynamics during 

pulmonary edema 
R01HL12493-10 Bioengineering analysis of microvascular 

function (cats, rabbits) 
P50HL-14218-07 0017 Pulmonary SCOR-Newborn lung 

center ■ Transvascular fluid exchange, vasoactive mediators 

in ROS (sheep, cat) 
P60HL-15162-07 0019 Comprehensive sickle cell center - 

RBCBIood rheology in sickle cell anemia and related 

disorders (human, animal) 
P01HL-1685I-04 0001 Human red cell membrane in 

health and disease - Rheology of erythrocyte membrane 

(human, amphiuma) 
POlHL-16910-05 0001 Regulation of the peripheral 

circulation - Quantitative studies of microcirculatory control 

(bats) 
POlHL-17421-05 0001 Regulation and exchange in the 

microcirculation - Mass transfer and microcirculatory 

function (rats) 
ROlHL-2063401 Blood volume and venous return in 

thermal strain (human) 
ROlHL-20818-02 Platelet storage at 22 degrees C 

(human) 
ROlHL-21145-02 Response of atria to hyperosmolality- 

Mechanisms (rabbits) 
ROIHL 21188-02 Pulsatory water flux and endothelial cell 

desquamation 
R23HL-2143402 Intrinsic control of coronary blood flow by 

chemicals (guinea pigs) 
ROlHL-21498-02 Pathophysiology of edema (rats, cats) 

BLOOD OSMOTIC PRESSURE, HYPEROSMOLARITY 

ROlHL-18288-04 Intraoperative protection of the 
myocardium (dogs, rats) 

BLOOO OXYGENATORS 

SEE CARDIOVASCULAR SURGERY, CIRCULATORY ASSIST 
BLOOO OXYGENATORS 

BLOOD PLATELET AGGREGATION 

SEE BLOOD PUTELETS, PUTELET AGGREGATION 
BLOOD PLATELET PRESERVATION 

SEE BLOOO PRESERVATION, PLATELET PRESERVATION 
BLOOD PLATELET TRANSFUSION 

SEE BLOOO TRANSFUSION. PLATELET TRANSFUSION 
BLOOD PLATELET TYPING 

P01HL-11310-12 Mechanisms of cardiovascular disease 
P60HL17265-04 0006 Community blood resource center 

support - Research-Evaluation of platelet transfusions 

(human, dog) 
P01HL-1882702 Platelet vessel wall interactions in 

thrombogenesis 

(contd) 



BLO 

P01HL18827-02 0006 Platelet vessel wall Interactions in 

thrombogenesis Platelet immune injury in man 
ROlHL-20856-02 Platelet transtusions-Usage and 
complications (human) 
BLOOD PLATELETPHERESIS 

SEE BLOOD TREATMENT. PLATELETPHERESIS 

BLOOD PLATELETS 

SEE ALSO BLOOD AND RE SYSTEM, MEGAKARYOCYTES 
NOlHI-32926-10 Analysis of lipoproteins (animals) 
RClHL-01601-30 Blood coagulation and hemorrhagic 

disease (horseshoe crabs) 
ROlHL-01648-31 Blood coagulation and hemophilia (dogs, 

swine) 
ROlHL-01803-23 0017 Arteriosclerosis, glomerulonephritis, 
rheumatic fever - Contractile and relaxing proteins of blood 
vessels and platelets (mammals, human) 
R01HL0506218 Lipid metabolism in cultured cells 
(human, rats, rabbits) 
M POlHL-06314-17 Immunologic mechanisms in 

cardiovascular disease 
** P01HL-063U-17 0047 Immunologic mechanisms in 

cardiovascular disease • Role of intravascular coagulation 
(human, animals) 
POlHL-06314-17 0053 Immunologic mechanisms in 
cardiovascular disease - Cellular functions controlled by 
cyclic GMP (human, mice, guinea pigs) 
ROlHL-07379-13 Structure and function of fibrinogen 
(human) 
" R01HL08399-15 Platelet injury in infections and allergic 
diseases (human) 
ROlHL-09902-13 Comparative study of coagulation and 

vascular disease (animals) 
ROIHL 10582 12 Thrombosis and hemostasis-Analysis, 
methods and standards (human, cattle, venom) 
M POlHL-11414-11 Thrombosis and atherosclerosis program 
** POlHL-1 1414-11 0004 Thrombosis and atherosclerosis 
program Platelet function and nonthrombogenic surfaces 
(human) 
** ROlHL-11775-11 Platelet mechanisms in disease (human, 

primates) 
** ROIHLI 1880-10 Physiology and pathology of blood 

platelets (human, dogs) 
•* R01HL13036-08 Coronary thrombosis -Effects on 
myocardium and in vivo detection (dogs, monkeys) 
*• POlHL-13108-09 0014 Clinical heart transplantation - 
Platelets and coagulation in accelerated graft coronary 
atherosclerosis 
ROlHL-13160-08 Human thrombin (also cattle) 
ROlHL-13198-21 Blood coagulation-Physico-chemical 
properties (human, cattle) 
** POlHL-13262-07 0022 Arterial wall in atherosclerosis - 

Mechanisms of platelet prostaglanoln formation 
•* R01HL13336-09 Biochemistry and physiology of human 
platelets 
POlHL-13737-07 0026 Assisted circulation - Hemostatic 

mechanism (human, dogs) 
POlHL-13738-08 0004 Cardiac assist devices and 
artificial hearts - Hematological evaluation of prosthetic 
materials (calves) 
** ROlHL-14020-06 Characterization of myosin from blood 

platelets (rabbit) . 

M P50HL-14147-08 Specialized center of research in 

thrombosis . 

** P50HL-1414708 0001 Specialized center of research in 
thrombosis - Role of aspirin, other anti-platelet agents m 
platelet function (rat, human) 
P50HL-14147-08 0007 Specialized center of research in 
thrombosis • Radioactive tracers in recognition of 
intravascular coagulation (human, dogs) 
P50HL-14147-08 0016 Specialized center of research in 
thrombosis Nuclear medicine core laboratory (human, 
dogs, rats, rabbits) 
P50HL-14147-08 0017 Specialized center of research in 
thrombosis Core coagulation laboratory (human) 
" P50HL-14147-08 0018 Specialized center of research in 
thrombosis - Biochemical aspects of platelet function in 
thrombosis and cell growth (human) 
P50HL-14164-07 0044 A/S SCOR -Comparative and 
experimental atherosclerosis - Cell biology-atherosclerosis 
project (pigeons) 
P50HL-14217-08 0050 Specialized center of research in 
thrombosis • Electron microscopy section (dogs) 
" P50HL- 142 17-08 0055 Specialized center of research in 
thrombosis Coagulation section-Platelet coagulant activity 
(human) 
*• P50HL14217-08 0057 Specialized center of research in 
thrombosis - Pharmacology-Platelet biochemistry (human, 

animal) . 

*• P50HL-14217-08 0058 Specialized center of research in 

thrombosis Mechanisms of induction and inhibition of 

platelet reaction (human, pig) 
•* P50HL- 142 17-08 0059 Specialized center of research in 

thrombosis - Energy metabolism and platelet function 

(human) 
P50HL-14217-08 0061 Specialized center ot research in 

thrombosis - Pharmacology-Comparison of platelets and 

vascular smooth muscle (animal) 
P50HL-14217-08 0062 Specialized center of research in 

thrombosis - Coagulation section -factor VIII and Factor XII 

(human, cattle) 



62 

P50HL-14217-08 0063 Specialized center of research in 

thrombosis - Special clinical studies laboratory 
P50HL-14230-07 0093 A/S SCOR-Lipids, atherosclerosis 

and thrombosis - Clinical studies involving cellular lipid 

content (human) 

* P50HL-14230-07 0095 A/S SCOR-Lipids, atherosclerosis 

and thrombosis - Blood platelet adherence to endothelial 
smooth muscle cells, fibroblast (human) 
P50HL-14230-07 0096 A/S SCOR-Lipids, atherosclerosis 

and thrombosis - Ultrastructural studies of endothelial cells 
(human) 

* P50HL-14230-07 0097 A/S SCOR-Lipids, atherosclerosis 

and thrombosis - Studies of circulating platelet aggregates 
(human) 

* ROlHL-14344-07 Platelet function and adenine nucleotide 

metabolism (human) 
'* ROlHL-14697-07 Role of platelet membranes in 

hemostasis (human) 
" ROlHL-14890-07 Platelet prostaglandins (human, rabbits) 
POlHL-14985-07 0007 Adaptation to hypoxia - Control of 

pulmonary circulation, histamine and the sympathetics 
(animals) 
POlHL-14985-07 0011 Adaptation to hypoxia - 

Prostaglandins in the control of the pulmonary circulation 
(animals) , 

** R01HL14992-07 Mechanism of thrombin action (human) 
POlHL-15195-04 0002 Program project in biological 
materials - Structural and surface characterization 
** R01HL15226-06 Interaction of blood cells with fibrinogen 

and fibrin (human, animals) 
" ROlHL-15335-06 The nature of the collagen-platelet 
interaction (animals) 
P01HL-15486-a6 0005 Studies on thrombosis Isolation 
and characterization of PF4 antigens (rabbits) 
** ROlHL-15491-06 Blood coagulation-Platelet-plasma 
protein interaction (human) 
ROlHL-15593-05 Prolonged extracorporeal cardiopulmonary 
support (rats, sheep, rabbits) 
•* POlHL-15596-05 0012 Coagulation, fibrinolysis, 

hemostasis and hepatitis ■ Platelet function-Phorbol ester 
and zymosan-induced release activity 
** POlHL-15596-05 0014 Coagulation, fibrinolysis, 

hemostasis and hepatitis - Von Willebrand factor and 
platelet retention in glass bead columns (swine) 
" ROIHL- 156 16-04 Platelet membrane proteins in 
aggregation (human) 
ROlHL-15647-06 Hematopoietic studies of cyclic 

hematopoiesis (dogs) 
ROlHL-16254-05 Pathogenesis of bubble and clot 
formation (fish) 
** ROlHL-16355-05 Reactions of thrombin and collagen with 
platelets (human) 
POlHL-16387-04 0004 The blood vessel and 
thrombogenesis - Analysis of vascular basement membrane 
by enzymatic methods (human) 
POlHL-16411-04 0001 Blood systems in coagulation and 
vessel disease - Molecular studies of the role of 
complement in blood coagulation (human, rabbits) 
POlHL-16411-04 0002 Blood systems in coagulation and 
vessel disease - Early stages of coagulation and 
cardiovascular disease (human, rabbits) 
POlHL-16411-04 0003 Blood systems in coagulation and 
vessel disease - Molecular events involving the late stages 
of coagulation (rabbits) 
** POlHL-164 11-04 0004 Blood systems in coagulation and 
vessel disease - Platelets reactions in vascular injury 
(human, animals) 
POlHL-164 11-04 0006 Blood systems in coagulation and 
vessel disease - Factor Vll-lmmunochemistry and 
immunobiology (human, mice) 
ROlHL-16577-04 Lipoprotein lipase chemistry and function 
(rats, cattle, human) 
** ROlHL-16634-13 Regulation of metabolism in fibroblasts 
and platelets (human, rabbits, sheep) 
R01HL16642-05 Biochemistry and pathophysiology ot 

plasma kallikrein (human, animals) 
R01HL16646-05 Patbobiology of thromboembolic disorders 

(human) 
ROlHL-167 14-05 Endothelial cell communication in 

homeostasis (human, mammals) 
ROlHL-16757-04 'Autoimmune' thrombocytopenia (monkey) 
ROlHL-16921-05 Synthetic hydrogels as blood tolerable 

materials 
ROlHL-16938-05 Effect of physical forces on blood (dogs, 

t'll'''3n) . . , . i,k;«,\ 

R01HL-16952-05 Cardiovascular pathology (rats, rabbits) 
P01HL17430-05 0005 Control of coagulation - The 

activation of prothrombin (human, cattle, dogs) 
POlHL-17430-05 0008 Control of coagulation - Cultures 

of von Willebrand endothelial cells (pigs) 
ROlHL-17487-04 Adrenergic-vasoregulation interactions in 

hypertension (human) 
ROlHL-17503-03 Vascular bubbles in decompression 

sickness (minipig, dog, goat) 
*• ROlHL-17513-04 Role of PF-4 in detecting and promotmg 

thrombosis (human, primates) 
•* ROlHL-17525-03 Molecular basis of collagen-platelet 

interaction (human, rat) 
** ROlHL-17729-04 Stimulus-response coupling in platelets 

(human) 



BLO 

* POlHL-17812-04 0005 Thrombosis and plasma proteins - 

In vitro systems of normal platelets, white cells, sera 
(human) . 

* POlHL-17812-04 0007 Thrombosis and plasma proteins - 

Blood components-Response to endotoxin (dogs, baboons) 

* ROlHL-17930-03 Platelet membrane function-Assessment 

and application (animals) 
■* R01HL17973-04 Cultured aortic endothelial cells (human, 

cattle, dogs, swine) 
■* R01HL18030-04 The role of contractile proteins in 
platelets (human, rabbits) 
ROlHL-18179-03 Heart, platelet, and muscle myosins and 
actomyosins (cattle) , ^i j .u 

POIHL- 18208-04 0001 Center for the study of blood cell 
rheology - Physiological basis of reversible erythrocyte 
shape change (human, firefly) 
** ROlHL-18249-04 Isolation and identification of platelet 
membrane (human) 
ROIHL 18256-01 Optical properties of platelets and 
erythrocytes (rabbits, dogs, human) 
** ROIHL 18502-03 Enzymatic regulation of platelet function 
(human) 
ROlHL-18519-03 Albumin, endothelium and 

hemocompatibility (human, dog, cattle, rabbit) 
P01HL18576-03 0007 Thrombosis research program 
protect - Relationships between coagulability and 
thrombosis (human, animals) 
•• POlHL-18576-03 0011 Thrombosis research program 
project - Proteolysis and platelet function (human, cattle, 
rabbits) , , . ■ ., 

" ROlHL-18584-03 Effects of physical forces on platelets 

•• ROIHL- 18586-03 Role of platelet lipids in hemostasis and 

thrombosis (human) 
•* ROlHL-18650-03 Platelet collagen interaction (human) 
" R01HL18714-04 Cardiovascular matrix-Morphogenesis 

and maturation (human, chick embryo, mammal) 
M POlHL-18827-02 Platelet vessel wall interactions in 
thrombogenesis 
POlHL-18827-02 0001 Platelet vessel wall interactions in 
thrombogenesis - Role of endothelial cells in the production 
of thrombi (human, cattle) 
** P01HL18827-02 0006 Platelet vessel wall interactions in 

thrombogenesis - Platelet immune injury in man 
M P50HL-18828-03 Specialized center of research in 

thrombosis . 

** P50HL-18828-03 0001 Specialized center of research in 
thrombosis - Membrane biology and hemostasis (human) 
P50HL-18828-03 0002 Specialized center of research in 
thrombosis - Endothelial cell biology (human, guinea pig) 
P50HL-18828-03 0004 Specialized center of research in 
thrombosis ■ Membrane changes in platelet physiology-Role 
of complement (mice, human) 
** P50HL-18828-03 0008 Specialized center of research in 
thrombosis - Biochemistry, physiology-Platelets and 
subcellular platelet particles (human) 
** P50HL-18828-03 0009 Specialized center of research in 
thrombosis - Platelet formation and megakaryocyte cell 
biology (guinea pig, human) 
** ROlHL-18935-03 Platelets, fibrinogen, soluble tibrin 

interaction (human) 
** R01HL-18937-03 Cyclic nucleotides and calcium in 
platelets (human) 
ROlHL-19001-03 Atherosclerosis in bleeder and drug 
treated subjects (pigs) 
** ROlHL-19055-03 Platelet function during extracorporeal 
perfusion (human, mammals) 
ROlHL-19203-03 Surgical approach to congenital heart 
diseases (dogs, primates) 
** ROlHL-19270-03 Effects of erythropoiesis on platelets ana 
hemostasis (rats) . 

ROlHL-19323-03 Studies of platelet microtubule protein 
ROlHL-19806-03 Chemotactic control of airway phagocytes 
(human, rabbits) 
** ROlHL-19996-02 Role of membrane proteins in platelet 

function (human, rabbits) 
-* ROlHL-201 14-02 Collagen-platelet interaction and human 

aorta collagen (human) 
** ROlHL-20411-03 Platelet fatty acid metabolism in 
diabetes (rat, rabbit, guinea pig) 
ROlHL-20522-03 Peripheral arterial disease in the diabetic 
(human) 
" ROlHL-20794-02 Prostaglandin synthesis in human 

platelets (also in sheep, rabbit) 
** ROlHL-20826-02 Megakaryocyte proliferation and its 
control (mice) 
ROlHL-20902-02 Studies on marginal band system ot 

erythrocytes (amphibians, reptiles, fish) 
ROlHL-20924-02 Atherosclerosis and arterial cell functions 
(human, rabbits) 
** ROlHL-20956-02 Early events following stimulation ot 

human platelets , , . , . a 

" ROlHL-20971-10 Membrane glycoproteins of platelets ano 

leukocytes (human) 
** P50HL-21006-02 0004 Specialized center ot research in 
arteriosclerosis - Regulation of growth of human arterial 
smooth muscle cells by platelets 
** P50HL-2 1006-02 0006 Specialized center of research in 
arteriosclerosis - Intravascular coagulation and thrombosis 
in hyperlipidemia (human) 
** R23HL-21 128-02 ATP utilization in platelet contractile 

mechanisms (human, rabbits) 

(contd) 



•tttludes routine methodotogy OR covers only general proiects which preclude 
**Onaited significaiitly to above subject. 



indexing at the specific level. 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigators name and grant number. 



The mechanisni ol collagen lormation 



ROIHL 21217 01 Ion and S hydroxytiYptaniina tiansport by 

pittflttt 
R23HL 21413 02 Structure and function ol platelet 

calcium binding prptain (human) 
ROIHL 214/1 02 Structure function studies on actin and 

myosin (human, protojoa. labbits. cattle) 
R23HI 2149002 Studies ot eniymes in human platelet 

membranes 
ROIHL 21b92 01 Lipoproteins and coagulation factors in 

atherosclerosis (pigeons) 
ROIHL 21644 01 Fibronectin and lelated glycopioteins 

(human, rodents) 
R23HL'2173001 vWagll A new vWD deficient antigen 

(human) 
ROIHL 2176401 Ultramlcroanalysis ot prostaglandins and 

related compounds (rats) 
ROIHL 21988 01 Biochemistry of human platelet 

chemotaxis 
ROIHL 22081 20 

(human, cattle) 
ROIHL'22119 01 Biochemistry of platelet function in 

thrombosis and cell growth (rabbits) 
ROIHL'22194'02 Allosteric function of platelet contractile 

proteins (human) 
ROlHl-2227001 Platelet glycoprotein (human) 
ROIHI'2233801 Platelet adhesion and aggregation in a 

flow chamber (human) 
R23HL'22346 01 Hematological injury and pulmonaiy 

dysfunction (human, mammals) 
ROIHL 2240601 Isobaric vascular bubbles and 

decompression sickness (goats, models) 
*• ROIHL 2245501 Platelet concentration in the marginal 

layer (dogs, human) 
ROlHL-2247101 Biochemistry of prothrombin quick 

(human) 
** ROlHL-2250201 Role of phosphoinositides in human 

platelet secretion 
ROlHL'22505-01 Molecular pathology of fibrinogen and 

factor XIII (human, animals) 
ROlHL-2252701 Prostacyclin-thromboxanes in the 

cardiovascular system (human, rabbits) 
ROlHL-2257301 Treatment of post surgical 

vasoconstriction (dogs, monkeys, human, rats) 
ROlHL-2258201 Pulmonary and circulatory alterations 

induced by IGE 
ROlHL-2258302 Ultrastructural study of endothelium in 

thrombosis (human) 
M POlHL-2260201 Pathophysiology of the endothelium 
•* POlHL-2260201 0001 Pathophysiology of the 

endothelium - Platelet-endotbelial interactions in vitro 

(human, cattle) 
** POlHL-22602-01 0004 Pathophysiology of the 

endothelium - Endothelium, platelets smooth muscle and 

atherosclerosis (rabbits) 
*• POlHL-2263301 0003 Cellular and molecular biology of 

lipoprotein metabolism - Sterol metabolism in platelets and 

megakaryocytes (human, rabbits, guinea pigs) 
** NOlHV-42984-05 Interactions of modified biopolymers with 

blood (humans, rats) 

BLOOD PLATELETS, PLATELET ACTIVATING 
FACTOR 

SEE ALSO FATTY ACIDS, UNSATURATED FATTY ACIDS, 
THROMBOXANES 
POlHL-1 1310-12 0095 Mechanisms of cardiovascular 
disease • Blood and transfusion disorders (human, rats, 
monkeys) 
** ROlHL-17525-03 Molecular basis of collagen-platelet 
interaction (human, rat) 
ROlHL-1 7747-04 Endothelial injury and regeneration (rats) 
M POlHL-1864503 Biology of the artery wall and 

atherosclerosis 
** POIHL 18645-03 0001 Biology of the artery wall and 
atherosclerosis - Primate arterial smooth muscle and 
atherosclerosis 
POlHL-18645-03 0003 Biology of the artery wall and 

atherosclerosis - Synthesis of connective tissue proteins by 
smooth muscle cells (human, monkeys) 
POlHL-18645-03 0005 Biology of the artery wall and 
atherosclerosis - Effects of atherosclerosis risk factors on 
endothelium of the primate 
** POlHL-18645-03 0006 Biology of the artery wall and 

atherosclerosis - The platelet and atherosclerosis (monkeys, 
baboons) 
•* P50HL-18828-03 0005 Specialized center of research in 
thrombosis - Platelet inflammatory factors in thrombosis 
(human, guinea pig) 
P50HL-18828-03 0008 Specialized center of research in 
thrombosis - Biochemistry, physiology -Platelets and 
subcellular platelet particles (human) 
ROlHL-21533-02 Platelet inhibitor drug in coronary surgery 



(human) 
ROlHL-21565-02 

(rats, rabbits) 
ROlHL-22555-01 



Pathogenesis of inflammatory lung injury 

Structure and function of platelet 
activating factor (rabbits, human) 

BLOOD PLATELETS, PLATELET AGGREGATION 

SEE ALSO BLOOD COAGUUTION. ANTICOAGULANTS. PUTELET 
AGGREGATION INHIBITORS 
ROlHL-01648-31 Blood coagulation and hemophilia (dogs, 

swine) 
ROlHL-01661-27 Hemostatic mechanisms (human) 



«3 

ROIHl 01803 23 0014 ArtfrlOWlWMll. Itomerulanephrltii. 
rheumatic fever Regenerated tndolhlllum on lipid 
accumulation in arterial wall (rabbit) 
ROIML 03424 21 lormnlioii nnd properlioj ot prolhrombin 

derivatives (human, animals) 
POIHL 04664 18 0008 Cardiovascular and lung dynamlci 

Micrographic video imaging technique 
' POIHI U6312 1/ 0046 Surgical cardiology The 

lelalionship of pioslaglandins to heart disease 
POIHL 06350 17 0005 Hemostasis research program 

project Purification of plasma antihemophilic factor 
(human) 
' P01H106350 17 0019 Hemostasis research program 

pioiect Microcirculation (human, rats, rabbits) 
POIHL 06835 17 0063 Cardiovascular disease Studies 

on prostaglandins (human, rabbits) 
POIHL 07896 15 0057 Environmental biomedical research 
program Effects of dipyridamole and aspirin on 
decompression thrombocytopenia (human) 
• POIHL 11310 12 0095 Mechanisms of cardiovascular 

disease Blood and transfusion disorders (human, rats, 
monkeys) 
POIHL 11414 11 0037 Thrombosis and atherosclerosis 
program Vascular intimal injury and healing (rabbits, 
rats) 
ROlHL-11775-11 Platelet mechanisms in disease (human, 

primates) 
ROIHL 11802 10 Cardiovascular surgical research (dogs. 

sheep, swine, cats, monkeys) 
ROIHL 11880-10 Physiology and pathology of blood 

platelets (human, dogs) 
ROIHL 11897-11 Pathogenesis of experimental 

atherosclerosis (rabbits, guinea pigs) 
R01HL-11945-10 Synthesis of artificial lung and kidney 

systems (sheep, mice, swine) 
ROlHL-12839-09 Flow, transport and membrane 

phenomena in blood (human) 
ROIHL 13198-21 Blood coagulation- Physico-chemical 

properties (human, cattle) 
P01HL-13330-08 0056 Mechanical circulatory support - 

Blood compatibility linings (calves) 
ROIHL 13336-09 Biochemistry and physiology of human 
platelets 
' ROlHL-13466-08 Pulmonary platelets in shock, trauma 
and embolization (dogs, pigs, rats) 
P50HL-14147-08 0001 Specialized center of research in 

thrombosis - Role of aspirin, other anti-platelet agents in 
platelet function (rat. human) 
P50HL-14147-08 0012 Specialized center of research in 

thrombosis - Tissue culture study of arterial cells (human, 
hamster) 
P50HL-14147-08 0017 Specialized center of research in 

thrombosis - Core coagulation laboratory (human) 
P50HL-142 14-07 0031 Newborn lung center for hyaline 

membrane disease - Essential fatty acid deficiency and 
HMD (human) 
P50HL-14217-08 Specialized center of research in 

thrombosis 
P50HL-142 17-08 0051 Specialized center of research in 

thrombosis - Microcirculation section (bat. hamster) 
P50HL-14217-08 0054 Specialized center of research in 
thrombosis - Coagulation section-Platelet aggregation 
(human, pig. rabbit, dog) 
P50HL-14217-08 0055 Specialized center of research in 
thrombosis - Coagulation section -Platelet coagulant activity 
(human) 
P50HL-142 17-08 0057 Specialized center of research in 

thrombosis - Pharmacology-Platelet biochemistry (human, 
animal) 
P50HL-142 17-08 0058 Specialized center of research in 
thrombosis - Mechanisms of induction and inhibition of 
platelet reaction (human, pig) 
P50HL-1421708 0059 Specialized center of research in 
thrombosis - Energy metabolism and platelet function 
(human) 
P50HL-142 17-08 0061 Specialized center of research in 
thrombosis - Pharmacology-Comparison of platelets and 
vascular smooth muscle (animal) 
P50HL-14217-08 0063 Specialized center of research in 

thrombosis - Special clinical studies laboratory 
P50HL- 142 30-07 A/S SCOR-Lipids, atherosclerosis and 

thrombosis 
P50HL-14230-07 0094 A/S SCOR-Lipids, atherosclerosis 

and thrombosis - Studies of atherosclerosis and regression 
(monkeys) 
P50HL-14230-07 0095 A/S SCOR-Lipids, atherosclerosis 

and thrombosis - Blood platelet adherence to endothelial 
smooth muscle cells, fibroblast (human) 
P50HL-14230-07 0097 A/S SCOR-Lipids, atherosclerosis 

and thrombosis - Studies of circulating platelet aggregates 
(human) 
P50HL-14230-07 0098 A/S SCOR-Lipids, atherosclerosis 

and thrombosis - Molecular properties of factor VIII (cattle, 
human, mice) 
ROIHL 14344-07 Platelet function and adenine nucleotide 

metabolism (human) 
ROlHL-14595-07 Primary disorders of platelet function 

(human, rats) 
ROlHL-14697-07 Role of platelet membranes in 

hemostasis (human) 
ROlHL-14890-07 Platelet prostaglandins (human, rabbits) 



'Excludes routine methodok>gy OR covers only general projects which preclude indexing 
••Oriented significanthi to above subject. 



at the specific level. 



M Grant has subprojects descnbing specific research aspects 
See Appendix for investigator's name and grant number. 



•ID 

POIHI 14985 0/ 0014 Adaptation lo hypoxia High 

attitude pulmonary edema (human, raft, dogil 
ROIHl 14992 0/ Mechanitm of thrombin action (human) 
POIHI 15195 04 0004 Program project in biological 

materials Biological evaluation and turtace interaction 
studies (dogs) 
ROIHL 15215 06 Role of complement in inliavaicular 

coagulation (rabbits, mice) 
ROIHl 15226 06 Interaction of blood celli with fibrinogen 

and fibrin (human, animals) 
ROIHl 15230 05 Molecular basis of V Witlebrand'l OlMtM 

and hemophilia (human, cattle) 
ROIHl 15335 06 The nature of the collagen platelet 

interaction (animals) 
ROIHl 154/4 06 Structure and function of the 

antihemophilic factor (human, cattle) 
POIHL 15486 06 0004 Studies on thrombosis 

Thrombosis, intravascualr coagulation, platelet aggregation 
(dogs) 
ROIHL 15491 06 Blood coagulation Platelet plasma 
protein interaction (human) 
' POIHL 1559605 0012 Coagulation, fibrinotysis. 

hemostasis and hepatitis Platelet function Phorbol ester 
and zymosan induced release activity 
ROIHL 1561506 Structure function studies of human 
factor VIII/vWF 
' ROIHL 15616 04 Platelet membrane proteins in 
aggregation (human) 
ROIHL 15681 06 Coronary flow studies of partially 
obstructed vessels (dogs) 
' POIHL 15835-06 0004 Study of muscles related to heart 

disease Actomyosin systems and cell motility (slime 
molds, human) 
' P60HL-1599606 0001 Cincinnati comprehensive sickle 

cell center - Coagulation mechanisms in sickle cell disease 
(human) 
ROlHL-16355-05 Reactions of thrombin and collagen with 

platelets (human) 
POlHL-16387-04 0005 The blood vessel and 

thrombogenesis - Fluid engineering considerations in 
thrombogenesis 
ROlHL-16634-13 Regulation of metabolism in fibroblasts 

and platelets (human, rabbits, sheep) 
R01HL-16720-02 Platelet aggregation (human) 
R01HL-16938-05 Effect of physical forces on blood (dogs. 

human) 
P60HL-1 7265-04 0007 Community blood resource center 

support - Research-Massive transfusion and trauma 
(human) 
ROIHL 17355-04 Pulmonary vascular adjustments in 

circulatory collapse (dogs, rats) 
P01HL17430-05 Control of coagulation 
P01HL17430-05 0001 Control of coagulation - Porcine 

von Willebrand's disease 
POlHL-17430-05 0002 Control of coagulation - Isolation 

of ristocetin-von Willebrand factor (swine) 
POlHL-17430-05 0007 Control of coagulation - Platelet 

adhesion, aggregation, ultrastructure in flowing blood 
(human, animals) 
ROlHL-17462-03 Role of glycosphingolipids in platelet 

aggregation (rats, human, dogs) 
ROIHL- 175 13-04 Role of PF-4 in detecting and promoting 

thrombosis (human, primates) 
ROIHL-17516-04 Role of androgen as a risk factor in 

atherogenesis (human, animals) 
ROIHL- 17623-05 Initial events in thrombus formation on 

surfaces (human, rats) 
ROlHL-17729-04 Stimulus-response coupling in platelets 

(human) 
ROlHL-17769-03 New methods of studying blood 

coagulation kinetics 
POlHL-17812-04 Thrombosis and plasma proteins 
POlHL-17812-04 0004 Thrombosis and plasma proteins - 

Serum-platelet interaction (human) 
POlHL-17812-04 0005 Thrombosis and plasma proteins - 
In vitro systems of normal platelets, white cells, sera 
(human) 
ROlHL-18030-04 The role of contractile proteins in 

platelets (human, rabbits) 
ROlHL-18239-03 Dietary fat composition and 

prostaglandin synthesis (rats) 
R01HL-18256-01 Optical properties of platelets and 

erythrocytes (rabbits, dogs, human) 
ROlHL-18288-04 Intraoperative protection of the 

myocardium (dogs, rats) 
ROlHL-18321-03 Fluid shear or magnetic alignment of 

blood components (human) 
ROlHL-18502-03 Enzymatic regulation of platelet function 

(human) 
POIHL-18576-03 0001 Thrombosis research program 

project - Platelet damage from physical forces and 
artificial surfaces (human) 
POlHL-18576-03 0004 Thrombosis research program 

project - Mechanism and control of collagen-platelet 
interaction 
P01HL18576-03 0005 Thrombosis research program 
project - Molecular basis of von Willebrand's disease and 
hemophilia (human, cattle) 
POlHL-18576-03 0011 Thrombosis research program 

project - Proteolysis and platelet function (human, cattle, 
rabbits) 

(contd) 



BLO 

** R01HL-1858A03 Effects of physical forces on platelets 
(human) 
ROlHL-18625-03 Organization of arterial ground substance 
(cattle) 
•* ROlHL-1865003 Platelet collagen interaction (human) 
ROlHL-187 14-04 Cardiovascular matrix-Morphogenesis 

and maturation (human, chick embryo, mammal) 
POlHL-18827-02 0003 Platelet vessel wall interactions in 

thrombogenesis - Tumor cell and platelets in 
thrombogenesis and metastasis (human, animals) 
** POlHL-18827-02 0005 Platelet vessel wall interactions in 

thrombogenesis - Platelet vessel wall interactions in 
thrombogenesis (human) 
M P50HL-18828-03 Specialized center of research in 
thrombosis 
P50HL-18828-03 0001 Specialized center of research in 
thrombosis ■ Membrane biology and hemostasis (human) 
** P50HL-18828-03 0004 Specialized center of research in 
thrombosis ■ Membrane changes in platelet physiology-Role 
of complement (mice, human) 
*• PbOHL-18828-03 0005 Specialized center of research in 

thrombosis - Platelet inflammatory factors in thrombosis 
(human, guinea pig) 
** P50HL-18828-03 0008 Specialized center of research in 
thrombosis • Biochemistry, physiology-Platelets and 
subcellular platelet particles (human) 
ROlHL-18932-03 Brain microcirculation observed in vivo 

after trauma (mice) 
ROlHL-18935-03 Platelets, fibrinogen, soluble fibrin 
interaction (human) 
** ROlHL-18937-03 Cyclic nucleotides and calcium in 

platelets (human) 
** ROlHL-19001-03 Atherosclerosis in bleeder and drug 
treated subjects (pigs) 
ROlHL-19055-03 Platelet function during extracorporeal 

perfusion (human, mammals) 
ROlHL-19255-03 Evaluation of diagnostic clinical 
hemorrheology (human) 
*' ROlHL-19278-03 Ristocetin induced platelet aggregation 
(human) 
ROlHL-19323-03 Studies of platelet microtubule protein 
P50HL-19362-02 0006 A/S SCOR -Atherosclerosis in 
nonhuman primates • Effects of cigarette smoking on 
atherosclerosis (baboon) 
** ROlHL-19993-02 Optical detection of platelet aggregates 
(human, baboons) 
ROlHL-20079-02 0001 Thromboresistant material ■ Active 

and passive thromboresistant surfaces 
ROlHL-20079-02 0002 Thromboresistant material - 

Thromboresistant materials (sheep) 
ROlHL-20079-02 0003 Thromboresistant material ■ Blood 

surface interactions (human, cattle) 
ROlHL-201 14-02 Collagen-platelet interaction and human 
aorta collagen (human) 
** ROlHL-20140-02 Glycoproteins of platelet membrane and 

platelet function (human) 
** ROlHL-20337-02 Thromboembolic diseases (human) 
ROlHL-20411-03 Platelet fatty acid metabolism in 

diabetes (rat. rabbit, guinea pig) 
ROlHL-20517-03 Diabetes, somatotropin, factor VIII and 

atherosclerosis (human, animal) 
ROlHL-20520-03 Protein modification-The key to diabetic 
sequelae (human, animal) 
** ROlHL-20563-02 Restoring microcirculation after platelet 
aggregation 
ROlHL-20787-02 Thromboxanes and prostaglandins- 
Biochemical pharmacology (rabbits, human) 
** ROlHL-21001-01 Protein and thrombus deposition on 

vascular grafts 
** R23HL-21128-02 ATP utilization in platelet contractile 
mechanisms (human, rabbits) 
ROlHL-21239-02 Isolation and mechanism of action of 

thromboxane A2 (human, rabbits) 
ROlHL-21487-01 Molecular characterization of 

Glanzmann's thrombasthenia (human) 
R23HL-2 1490-02 Studies of enzymes in human platelet 

membranes 
ROlHL-21565-02 Pathogenesis of inflammatory lung iniury 

(rats, rabbits) 
ROlHL-21769-01 Blood compatible benzamidine containing 
polymers 
** ROlHL-21988-01 Biochemistry of human platelet 

chemolaxis 
•* P01HL22163-01 0001 Surface thrombogenesis - 

Mechanisms and prevention - Initial blood protein and 
platelet interactions with biomaterials (baboons) 
POlHL-22163-01 0002 Surface thrombogenesis - 

Mechanisms and prevention - Laser-scattering detection of 
microemboli in blood flow (baboons) 
ROlHL-22219-01 Prostacyclin and peroxides in blood and 
membrane disease 
** ROlHL-22338 01 Platelet adhesion and aggregation in a 
flow chamber (human) 
ROlHL-22355-01 Purification, structure and function of 
factor VIII (human) 
** ROlHL-224 15-01 Mechanisms responsible for disease 
severity in asthma (human) 
ROlHL-22445-01 Platelet inhibitors -Effect on coronary 

bypass grafts (dogs) 
ROlHL-22502-01 Role of phosphoinositides in human 
platelet secretion 



64 

ROlHL-22582-01 Pulmonary and circulatory alterations 
induced by IGE 
** ROlHL-22585-01 Plasma proteins adsorbed to artificial 
organs (human, rabbits) 
POlHL-22602-01 0001 Pathophysiology of the 
endothelium - Platelet-endothelial interactions in vitro 
(human, cattle) 
R23HL-22621-01 Blood cell-mediated pulmonary (human) 
** POlHL-22633-01 0003 Cellular and molecular biology of 

lipoprotein metabolism - Sterol metabolism in platelets and 
megakaryocytes (human, rabbits, guinea pigs) 
** ROlHL-22738-01 Role of bioelectric potentials in platelet 
adherence (bats, rats, hamsters) 
ROlHL-22739-01 Evolution and progression of pediatric 
atherosclerosis 
** ROlHL-22946-01 Prostaglandins, platelet aggregation and 

vasoactivity (human, rats, rabbits) 
** ROlHL-22951-01 Studies on the affect of vitamin E on 

platelets (human, rats) 
** ROlHL-230 10-01 Control and mechanism of platelet 

aggregation (human) 
** ROlHL-231 14-01 Control of platelet aggregation in shock 
(dogs, rabbits) 
ROlHL-23899-01 Flow and flexing at blood/biomaterial 
interfaces 
** NOlHV-52907-04 Interactions of platelets with collagens 

(human, mammals) 
BLOOD PLATELETS DEFECTS QUALITATIVE 

SEE BLOOD PLATELETS DISORDERS. THROMBOCYTOPATHY 
BLOOD PLATELETS DISORDERS 

SEE ALSO BLOOD AND RE DISORDERS. HEMORRHAGIC 

DISORDERS 
SEE ALSO BLOOD COAGULATION DISORDERS 
** POlHL-06314-17 0047 Immunologic mechanisms in 

cardiovascular disease - Role of intravascular coagulation 
(human, animals) 
** ROlHL-09902-13 Comparative study of coagulation and 
vascular disease (animals) 
ROlHL-10582-12 Thrombosis and hemostasis -Analysis, 
methods and standards (human, cattle, venom) 
** ROlHL-11880-10 Physiology and pathology of blood 

platelets (human, dogs) 
** ROlHL-13629-08 Hemorrhagic diseases (human) 
ROlHL-13754-08 Postoperative thromboembolism in 
surgical patients (human) 
** P50HL-142 17-08 0059 Specialized center of research in 
thrombosis - Energy metabolism and platelet function 
(human) 
** ROlHL-14595-07 Primary disorders of platelet function 
(human, rats) 
ROlHL-14637-05 Thrombopoietin -Immunoassay and 

characterization (mice) 
ROlHL-15616-04 Platelet membrane proteins in 

aggregation (human) 
ROlHL-161 54-05 Membrane lung perfusion for acute 

respiratory failure (sheep, baboons) 
POlHL-16387-04 0009 The blood vessel and 

thrombogenesis - Role of pituitary gland in the 
pathogenesis of arteriosclerotic lesions (rats) 
ROlHL-16720-02 Platelet aggregation (human) 
" POlHL-17430-05 0007 Control of coagulation • Platelet 
adhesion, aggregation, ultrastructure in flowing blood 
(human, animals) 
ROlHL-17462-03 Role of glycosphingolipids in platelet 

aggregation (rats, human, dogs) 
POlHL-17812-04 0002 Thrombosis and plasma proteins - 

Activators of fibrinolysis -Synthesis and degradation 
(human, cattle) 
ROIHL 18586-03 Role of platelet lipids in hemostasis and 
thrombosis (human) 
** ROlHL-18650-03 Platelet collagen interaction (human) 
R01HL-18815-03 Surgical vascular disorders (human, 
dogs) 
** POlHL-18827-02 0006 Platelet vessel wall interactions in 

thrombogenesis - Platelet immune injury in man 
** ROlHL-19996-02 Role of membrane proteins in platelet 
function (human, rabbits) 
ROlHL-20140-02 Glycoproteins of platelet membrane and 

platelet function (human) 
ROlHL-204 11-03 Platelet fatty acid metabolism in 

diabetes (rat, rabbit, guinea pig) 
ROlHL-20794-02 Prostaglandin synthesis in human 
platelets (also in sheep, rabbit) 
** ROlHL-21460-02 Lipoproteins, hemostasis and 
atherosclerosis (human, rabbits) 

BLOOD PLATELETS DISORDERS, 

THROMBOCYTHEMIA, HEMORRHAGIC 

ROlHL-01601-30 Blood coagulation and hemorrhagic 

disease (horseshoe crabs) 
ROIHL-19270-03 Ettects of erythropoiesis on platelets and 

hemostasis (rats) 
" POlHL-22602-01 0001 Pathophysiology of the 

endothelium - Platelet-endothelial interactions in vitro 

(human, cattle) 
POlHL-22602-01 0004 Pathophysiology of the 

endothelium - Endothelium, platelets smooth muscle and 

atherosclerosis (rabbits) 



BLO 

BLOOD PLATELETS DISORDERS, 
TH ROMBOCYTOPATH Y 

SEE ALSO BLOOD COAGULATION DISORDERS, VON 

WILLEBRANDS DISEASE 
R01HL02254-23 Blood coagulation and hemorrhagic 

disease (human, animals) 
ROlHL-07652-14 Destruction of red blood cells in 

hemolytic anemias (human, guinea pigs) 
ROlHL-09902-13 Comparative study of coagulation and 

vascular disease (animals) 
P50HL-14217-08 0059 Specialized center of research in 

thrombosis - Energy metabolism and platelet function 

(human) 
ROlHL-14595-07 Primary disorders of platelet function 

(human, rats) 
ROlHL-15616-04 Platelet membrane proteins in 

aggregation (human) 
** ROlHL-21487-01 Molecular characterization of 

Glanzmann's thrombasthenia (human) 
ROlHL-23010-01 Control and mechanism of platelet 
aggregation (human) 

BLOOD PLATELETS DISORDERS, 
TH ROMBOCYTOPEN lA 

" POlHL-07896-15 0057 Environmental biomedical research 
program - Effects of dipyridamole and aspirin on 
decompression thrombocytopenia (human) 
R01HL11880-10 Physiology and pathology of blood 

platelets (human, dogs) 
P50HL-14217-08 0055 Specialized center of research in 

thrombosis - Coagulation section-Platelet coagulant activity 
(human) 
ROlHL-14739-06 The role of leukocytes in thrombotic 

disease (human, dogs) 
P01HL-14985-07 0007 Adaptation to hypoxia - Control of 
pulmonary circulation, histamine and the sympathetics 
(animals) 
ROIHL 15593-05 Prolonged extracorporeal cardiopulmonaty 

support (rats, sheep, rabbits) 
ROlHL-15647-06 Hematopoietic studies of cyclic 

hematopoiesis (dogs) 
POlHL-16411-04 0004 Blood systems in coagulation and 
vessel disease - Platelets reactions in vascular injury 
(human, animals) 
ROIHL 16646-05 Pathobiology of thromboembolic disorders 

(human) 
ROlHL-16714-05 Endothelial cell communication in 
homeostasis (human, mammals) 
** ROlHL-16757-04 'Autoimmune' thrombocytopenia (monkey) 
P60HL-17265-04 0006 Community blood resource center 
support - Research-Evaluation of platelet transfusions 
(human, dog) 
POlHL-18576-03 0007 Thrombosis research program 

project - Relationships between coagulability and 
thrombosis (human, animals) 
POlHL-18645-03 0006 Biology of the artery wall and 
atherosclerosis - The platelet and atherosclerosis (monkeys, 
baboons) 
ROlHL-19203-03 Surgical approach to congenital heart 

diseases (dogs, primates) 
ROlHL-20140-02 Glycoproteins of platelet membrane and 

platelet function (human) 
ROlHL-20818-02 Platelet storage at 22 degrees C 

(human) 
ROlHL-20856-02 Platelet transfusions-Usage and 

complications (human) 
ROlHL-20924-02 Atherosclerosis and arterial cell functions 

(human, rabbits) 
ROlHL-21429-02 Transport of LDL in arterial wall (human, 

mammals) 
ROlHL-21565-02 Pathogenesis of inflammatory lung injury 
(rats, rabbits) 
BLOOD PLATELETS DISORDERS, 

THROMBOCYTOPENIC PURPURA 
** ROlHL-13336-09 Biochemistry and physiology of human 

platelets 
•* ROlHL-13629-08 Hemorrhagic diseases (human) 

P60HL-17265-04 0006 Community blood resource center 
support - Research-Evaluation of platelet transfusions 
(human, dog) 
** POlHL-18576-03 0011 Thrombosis research program 
project - Proteolysis and platelet function (human, cattle, 
rabbits) 
POlHL-18827-02 0006 Platelet vessel wall interactions in 

thrombogenesis - Platelet immune injury in man 
P50HL-18828-03 0005 Specialized center of research in 

thrombosis ■ Platelet inflammatory factors in thrombosis 
(human, guinea pig) 
BLOOD PRESERVATION 

SEE ALSO BLOOD AND RE SYSTEM, BLOOD FRACTIONATION 
*♦ ROIHL 07449-17 Formation and survival of red blood cells 

(human) 
M POlHL-09011-15 A research and resource program in 
blood 
POlHL-09011-15 0017 A research and resource program 

in blood - Operations research laboratory 
♦* P01HL09011-15 0022 A research and resource program 

in blood - Cryopreservation of blood components (human) 
ROlHL-11154-12 Blood group antigens and antibodies 

(human) 

(contd) 



•Excludes routine melhodokigy OR covers onhi general projects which preclude 
"Oriented significantly to above subiect 



indexing at the specific level. 



M Grant has subprojects descnbing specific research aspects. 
See Appendix for investigator's name and grant number. 



National blood banking data needs 
Collection, function and transfusion ol 

Collection, (unction and transtusion of 

Collection, function and transtusion of 

Collection, (unction and transfusion of 



BLO 

ROIMI is;?? 06 Htmorthaoloiy studies related to in wn/o 
blood (low (human) 
•• ROIHI 16931 04 Red cell s(ora|e and (ians(usion 

(human, animals) 
M P60HI i;?65 0< Community blood resource center support 
P60HL i;?6b04 0001 Community blood resource center 

support Demonstration and evaluation 
P60HL 1/26S04 000? Community blood resource center 

support Research Massive transtusion and trauma 
(human) 
•• ROlHl 1/47904 Blood storage The production o( 
cardiotoiic material (dogs, human, swine) 
ROlHl ??6?1 01 Removal o( senescen( and s(ored human 
red cells 

BLOOD PRESERVATION, BLOOD BANKS, 
CENTERS-RESOURCES-REGISTRIES 

NOIHB 62967 03 Blood banking seivices on a regional 
basis 
"• N01HB62968-07 
N01H8 6297002 

granulocytes 
NOlHB-6297103 

granulocytes 
NOlHB-62972 05 

granulocytes 
NOlHB-6297305 
granulocytes 
•' P01HL0901115 0017 A research and resource program 

in blood Operations research laboratory 
•• P01HL0901115 0022 A research and resource program 
in blood Cryopreservation of blood components (human) 
R01HL13567 06 Ion transport across cell membranes 
(human) 
** ROIHL 13881 08 The American Red Cross National 
Fractionation Center 
ROIHL 15722-06 Hemorrheology studies related to in vivo 
blood flow (human) 
M P60HL 1726504 Community blood resource center support 
P60HL1 7265-04 0001 Community blood resource center 

support - Demonstration and evaluation 
P60HL- 17265-04 0010 Community blood resource center 
support ■ Blood resources educational program 

BLOOD PRESERVATION, LEUKOCYTE 
PRESERVATION 

P60HL-1 7265-04 0009 Community blood resource center 
support - Research -Developing granulocyte transfusion 
therapy (human, rabbit) 

ROlHL-1747904 Blood storage-The production of 
cardiotoxic material (dogs, human, swine) 

BLOOD PRESERVATION, PLATELET 
PRESERVATION 

** ROlHL-13629-08 Hemorrhagic diseases (human) 

P50HL-14217-08 0055 Specialized center of research in 
thrombosis ■ Coagulation section-Platelet coagulant activity 
(human) 
P60HL-1 7265-04 0006 Community blood resource center 
support - Research -Evaluation of platelet transfusions 
(human, dog) 

Enzymatic regulation of platelet function 



ROIHL-18502-03 

(human) 
ROlHL-19323-03 
ROlHL-19996-02 



Studies of platelet microtubule protein 
Role of membrane proteins in platelet 
function (human, rabbits) 
ROlHL-20666-02 Cell biology of platelet preservation 



(human) 
** R01HL-20695-02 
** ROlHL-20716-02 

platelets (rats) 
** R01HL-207I8-02 

platelets 
** ROlHL-20788-02 

transfusion 
** ROlHL-20818-02 

(human) 



Stored plateletes (human) 

Freezing and electromagnetic thav»ing of 

Microstructural integrity of stored human 

Preservation of human platelets for 

Platelet storage at 22 degrees C 



BLOOD PRESSURE 

SEE CARDIOVASCULAR FUNCTION, BLOOD PRESSURE 
BLOOD PRESSURE GRADIENT TECHNIQUE 

SEE CARDIOVASCULAR DISORDERS DIAGNOSIS BLOOD 
PRESSURE GRADIENT TECHNIQUE* 
BLOOD PROTEINS 

SEE ALSO ALBUMINS. SERUM ALBUMIN 

SEE ALSO BLOOD COAGUUTION 

SEE ALSO BLOOD PROTEINS DISORDERS 

SEE ALSO GLOBULINS. CORTICOSTEROID BINDING GLOBULIN 

SEE ALSO GLOBULINS. SERUM GLOBULINS 

SEE ALSO HALOPROTEINS. THYROXINE BINDING PROTEINS 

SEE ALSO HEMOPROTEINS. HAPTOGLOBINS 

SEE ALSO HEMOPROTEINS. HEMOGLOBIN 

SEE ALSO IMMUNOLOGY, COMPLEMENT 

SEE ALSO METALLOPROTEINS. CERULOPLASMIN 

SEE ALSO METALLOPROTEINS. FERRITIN 

SEE ALSO METALLOPROTEINS, HEMERYTHRIN 

SEE ALSO MHALLOPROTEINS. HEMOCYANIN 

SEE ALSO METALLOPROTEINS. TRANSFERRIN 
N01HI-32926-1Q Analysis of lipoproteins (animals) 
ROlHL-02262-23 Mechanisms regulating plasma proteins 
and solutes (human, dogs) 



65 

POIHL 0.11/4 ?3 0009 Mechanisms ol icul* vascular 

rtJition lo iniury Mast cell lipid interaction (human, rats) 
M POIHI 09011 I'j A research and resource program in 

blood 
•• POIHI 0901 1 I'j 000? A research and resource program 

in blood Biosynthesis ol librinogen (dogs) 
ROIHI 09/39 IJ Biophysical studios of proteins (human) 
POIHI 116/8 II 0036 Cardiovascular dynamics and their 

control Pulmonary capillary dynamics and edema (dogs) 
POIHL 12157 11 0055 functions and mechanisms of cell 

membrane ion transport Growth and development of 
synthetic strand heart cells in culture (chick embryo) 
ROIHL 12421 10 Pathophysiology of circulatory shock 

(dogs, baboons) 
ROIHL 12839 09 Flow, transport and membrane 

phenomena in blood (human) 
ROIHL 13596 07 Clearance of plasma proteins from 

alveoli 
POIHL 1373808 0004 Cardiac assist devices and 

artificial hearts Hematological evaluation of prosthetic 
materials (calves) 
ROIHL 13881 08 The American Red Cross National 

Fractionation Center 
P50HL 14147 08 0006 Specialized center of research in 

thrombosis Clearance mechanisms of coagulation 
moieties (human, labbits. rodents) 
P60HL-1516905 0018 Support for center (or sickle cell 

disease Studies on sickle cell disease (human, rats, 
dogs) 
POIHL 15195-04 0002 Program project in biological 

materials Structural and surface characterization 
** ROlHL-15491 06 Blood coagulation -Platelet-plasma 
protein interaction (human) 
ROlHL-15520-06 Total blood replacement by fluorocarbons 

and polyols (rats) 
POlHL-15596-05 0017 Coagulation, fibrinolysis. 

hemostasis and hepatitis - Heparin and antithrombin III 
POlHL-15596-05 0020 Coagulation, fibrinolysis. 

hemostasis and hepatitis - Affinity chromatography 
ROlHL-15646 03 Lipid studies in vascular smooth muscle 

cells (human, monkeys) 
P60HL-15999-05 0020 Miami comprehensive sickle cell 

center - Deficiency in complement dependent humoral 
immunity -Sickle cell disease (human) 
R01HL-16601-05 Structure and function of blood proteins 

(human, cattle) 
R01HL-I6921-05 Synthetic hydrogels as blood tolerable 

materials 
P60HL-17265-04 0002 Community blood resource center 

support - Research-Human factor VIII 
P60HL-17265-04 0003 Community blood resource center 
support - Research-Human factor IX-Role in intrinsic 
clotting (also baboons, dogs) 
P01HL-I7430-05 0002 Control of coagulation - Isolation 

of ristocetin-von Willebrand factor (swine) 
ROlHL-17623-05 Initial events in thrombus formation on 
surfaces (human, rats) 
^i POlHL-17812-04 Thrombosis and plasma proteins 

POlHL-17812-04 0001 Thrombosis and plasma proteins - 

Thrombosis and plasma proteins (cattle, guinea pigs) 
POlHL-1781204 0004 Thrombosis and plasma proteins - 

Serum-platelet interaction (human) 
POlHL-17812-04 0005 Thrombosis and plasma proteins - 

In vitro systems of normal platelets, white cells, sera 
(human) 

* POlHL-17812-04 0007 Thrombosis and plasma proteins - 

Blood components-Response to endotoxin (dogs, baboons) 
ROlHL-17995-04 Cellular synthesis and release of 

mucopolysaccharides (rabbits) 
ROlHL-18010-04 Capillary transport of large molecules 

(dogs, sheep) 
ROlHL-18012-04 Cellular defects in nocturnal 

hemoglobinuria (human) 
R01HL-I8321-03 Fluid shear or magnetic alignment of 

blood components (human) 
ROlHL-18473-04 Genesis of atherosclerotic lesions 

(human, mules) 

* ROlHL-185 19-03 Albumin, endothelium and 

hemocompatibility (human, dog. cattle, rabbit) 

* P50HL-191 57-02 0008 Studies in cystic fibrosis and 

bronchiolitis - Serum proteins in cystic fibrosis (human) 
ROlHL-193 16-03 Study of glomerular permeability (fish. 

turtle, frog, chordates, Crustacea) 
ROlHL-19399-02 Atherosclerosis-Early events and 

regression factors (rats) 

* ROlHL-19419-03 Cellular interactions with foreign 

materials (mammals) 
R01HL-I9539-03 Pathology of hypertensive-associated 

arteritis (rabbits) 
ROlHL-20079-02 0001 Thromboresistant material - Active 

and passive thromboresistant surfaces 
■ ROlHL-20079-02 0003 Thromboresistant material - Blood 

surface interactions (human, cattle) 
ROlHL-20 106-02 Coupling of platelet contractile proteins 

to fibrin (human) 
ROlHL-2030102 Genetics of glycosyltransferases in 

human blood 
ROIHL 20846-02 Purification of bovine plasminogen 

proactivator 
P50HL-21006-02 0003 Specialized center of research in 

arteriosclerosis - Transport of vitamin A in plasma (human 

rat) 



BLO 



Mechaniimt of reeipantion pulmofiary 



*&dudes iDutioe methodokigy OR covers only general projects which preclude indexing 
Oriented significantly to above subject 



at the specific level. 



M Grant has subprojects descnbing specific research aspects 
See Appendix for investigators name and grant number. 



R71HI 71050 07 

edema (ribbitil 
ROIHI 71498 02 Pathophyiiolofy of edema (rati, call) 
RUIHI 2154801 Pttho|tn«tis ol pulmonary 
thromboembolic diteatt (human, mammali) 
ROIHI 7159201 lipoproleini ind coi|ulitton fictori In 

atherosclerosis (pigeons) 
ROIHI 7164401 Fibronectin and related (tycoprottini 
(human, rodents) 
•* ROIHI 71/91 01 Precipitation of proteins with poly 
(ethylene glycol) (human) 
ROIHI 21988 01 Biochemistry ol human platelet 
chemotaiis 
•• POIHI 77163 01 0001 Surface thrombogenesis 

Mechanisms and prevention Initial blood protein and 
platelet interactions with biomaterials (baboons) 
POIHI 22163 01 0003 Surface thrombogenesis 

Mechanisms and prevention In vivo mechanisms of 
biomaterial thrombogenesis and its prevention (baboons) 
*• ROIHL 22530 01 Active site studies on blood proteases 
(human) 
ROIHL 22569 02 Intestinal secretion Capillary and tissue 
forces (dogs, cats) 
** ROIHL 22585 01 Plasma proteins adsorbed lo artificial 

organs (human, rabbits) 
*• POIHL 22602 01 0002 Pathophysiology of the 

endothelium Molecular charge and endothelial 
permeability (rats, mice) 
•* R23HL 22933 01 Transvascular fluid and protein exchange 

in the lung (sheep) 
" ROIHL 2389901 Flow and flexing at blood/biomaterial 

interfaces 
•• NOlHR.72923-01 Cystic fibrosis factor identification and 

quantification (human) 
** NOlHV-32917 08 Materials development and testing 

BLOOD PROTEINS DISORDERS 

SEE ALSO HEMOPROTEINS. HEMOGLOBIN. METHEMOGLOBIN 
SEE ALSO HEMOPROTEINS. METHEMOGLOBINEMIA 
SEE ALSO LIPOPROTEINS BLOOD. DYSLIPOPROTEINEMIAS 
POlHL-09011-15 0005 A research and resource program 

in blood Characterization of hepatitis-B antigen and the 
cause of serum hepatitis (human) 
R01HL-09I63-13 Control mechanisms in hemostasis 

(human) 
ROlHL-19255-03 Evaluation of diagnostic clinical 

hemorrheology (human) 
ROlHL-22607-01 Role of apolipoprotein E in lipoprotein 
metabolism (human) 
" ROlHL-22618-01 Role of apolipoproteins in 
hypertriglyceridemia (human) 

BLOOD PROTEINS DISORDERS, HYPERVISCOSITY 
SYNDROME 

ROlHL-1925503 Evaluation of diagnostic clinical 

hemorrheology (human) 
R01HL19456-03 Immunoglobulins associated with serum 

hyperviscosity (human) 

BLOOD PROTEINS DISORDERS, 
HYPOPROTEINEMIA 

SEE ALSO LIPOPROTEINS BLOOD. HYPOUPOPROTEINEMIA 
R01HL12493-10 Biocngineering analysis of microvascular 
function (cats, rabbits) 

BLOOD PROTEINS DISORDERS CONGENITAL 

SEE ALSO BLOOD COAGUUTION DISORDERS 

SEE ALSO HEMOPROTEINS, HEMOGLOBINOPATHIES 

SEE ALSO METABOLIC DISORDERS INBORN. ACATAUSEMIA 

SEE ALSO METABOLIC DISORDERS INBORN. 

HEPATOLENTICULAR DEGENERATION 
SEE ALSO METABOLIC DISORDERS INBORN. 

HYPOLIPOPROTEINEMIAS FAMILIAL 
ABETALIPOPROTEINEMIA 
SEE ALSO METABOLIC DISORDERS INBORN. 

HYPOLIPOPROTEINEMIAS FAMILIAL. TANGIER 
DISEASE 
ROlHL-02799-22 Abnormal hemoglobins (human) 
POlHL-06350-17 0015 Hemostasis research program 

project - Genetics (human) 
ROlHL-07449-17 Formation and survival of red blood cells 

(human) 
ROlHL-09163-13 Control mechanisms in hemostasis 

(human) 
ROlHL-09902-13 Comparative study of coagulation and 
vascular disease (animals) 
** R01HL-I6872-04 Antihemophilic factor (human) 

ROlHL-18834-04 Metal-dependent complex formation in 

blood coagulation (human, cattle) 
ROlHL-19267-02 Serial comparative study of Von 

Willebrand's disease (human) 
R01HL-20074-02 Structure and function of amidinafed 

human hemoglobin 
ROlHL-20092-02 Structural and biological properties of 

fibrinogen (human, rabbits) 
ROlHL-20142-02 Functional studies of abnormal human 

hemoglobins 
ROlHL-20161-02 Role of gamma-carboxyglutamic acid in 

blood coagulation (human, cattle) 
ROlHL-20920-01 Control of hemoglobin synthesis (baboon) 
ROlHL-21403-02 Blood clotting kinetics studied by 
radioimmunoassay (human) 

(contd) 



BLO 

** R23HL-21730-01 vWagll-A new vWD deficient antigen 

(human) 
** ROlHL-22505-01 Molecular pathology of fibrinogen and 
factor XIII (human, animals) 
R23HL-22799-01 Interaction of the complement and 
coagulation systems (monkeys) 
BLOOD REPLACEMENT PERFUSION (WHOLE 
BODY) 
SEE BLOOD TREATMENT. WHOLE BODY PERFUSION (BLOOD 
REPLACEMENT) 

BLOOD RESOURCES - REGISTRIES 

SEE BLOOD PRESERVATION, BLOOD BANKS, CENTERS- 
RESOURCES-REGISTRIES 

BLOOD RHEOLOGY 

SEE ALSO BLOOD OSMOTIC PRESSURE 

SEE ALSO BLOOD VISCOSITY-VISCOELASTICITY 

SEE ALSO CARDIOVASCULAR DISORDERS DIAGNOSIS, BLOOD 

FLOW MEASUREMENTS* 
SEE ALSO CARDIOVASCULAR FUNCTION. BLOOD CIRCULATION 

DYNAMICS (GENERAL) 
SEE ALSO CARDIOVASCULAR FUNCTION, BLOOD FLOW 
SEE ALSO CARDIOVASCULAR FUNCTION, BLOOD FLOW 

IMPEDANCE 
SEE ALSO CARDIOVASCULAR FUNCTION. BLOOD FLOW 

OSCILUTORY 
SEE ALSO CARDIOVASCULAR FUNCTION. VASOMOTION, PULSE 

PRESSURE WAVES 
SEE ALSO HEART DISORDERS DIAGNOSIS, PICK METHOD* 
** ROlHL-1 1901-12 0017 Effects of metabolic surgery on 
the hyperlipidemias - Membrane permeability, blood 
viscosity, oxygen uptake-Rheology studies (rabbits) 
** POlHL-12738-10 0069 Physiologic pharmacology and its 
clinical applications - Blood rheology in coronary heart 
disease (dogs) 
** ROlHL-12839-09 Flow, transport and membrane 
phenomena in blood (human) 
RClHL-13426-09 Left ventricular bypass for myocardial 
infarction (cattle, human) 
** POlHL-14388-07 0217 Regulation of the circulation in 
pathological states - Fluid mechanics of aortic flow (dogs, 
human) 
** P60HL15162-07 0019 Comprehensive sickle cell center ■ 
RBC-Blood rheology in sickle cell anemia and related 
disorders (human, animal) 
ROIHL- 152 70-06 Local mechanical properties of the aortic 
tissue (dogs, pigs) 
** R01HL-15722-06 Hemorrheology studies related to in vivo 
blood flow (human) 
ROlHL-16236-04 Detailed characteristics of coronary blood 

flow (horses, dogs, calves) 
POlHL-16387-04 0005 The blood vessel and 
thrombogenesis • Fluid engineering considerations in 
thrombogenesis 
** ROlHL-16421-08 Determinants of RBC deformability and 
capillary flow (human, mice) 
ROIHL- 16580-04 Mathematical models for studying sickle- 
cell disease 
•* ROlHL-16711-05 RBC and endothelial membrane material 

characteristics (human) 
•* POlHL-15833-04 0009 Hemoglobin and red cell system in 
hemoglobinopathies • Rheological studies of sickled cells 
(human) 
M POlHL-16851-04 Human red cell membrane in health and 

disease 
** POlHL-16851-04 0001 Human red cell membrane in 

health and disease - Rheology of erythrocyte membrane 
(human, amphiuma) 
** POlHL-1685104 0003 Human red cell membrane in 
health and disease - Modeling membrane mechanics and 
blood rheology 
POlHL-16851-04 0005 Human red cell membrane in 
health and disease - Relation of hemoglobin species to 
membrane properties (human) 
** POlHL-16851-04 0008 Human red cell membrane in 

health and disease - Force balance in red cell interactions 
(human) 
POlHL-16851-04 0009 Human red cell membrane in 

health and disease - Blood cell properties in circulatory 
regulation (dogs, rabbits) 
ROlHL-16938-05 Effect of physical forces on blood (dogs, 
human) 
** ROlHL-17408-03 Fresh blood rheology-Relation to 
cardiovascular risk (human) 
ROlHL-17591-03 Development of electromagnetic 

rheoangiography (human, dogs) 
ROlHL-17821-03 Cavitation phenomena near prosthetic 
devices 
M POlHL-18208-04 Center for the study of blood eel! 
rheology 
P01HL1820804 0004 Center for the study of blood cell 

rheology Splenic microcirculation (rats, mice) 
** POlHL-18208-04 0005 Center for the study of blood cell 
rheology - RBC deformability and capillary flow 
interrelations (human, mice) 
POlHL-18208-04 0006 Center for the study of blood cell 
rheology - Analysis of flow in arterioles and capillaries 
(human) 
** R01HL18321-03 Fluid shear or magnetic alignment of 
blood components (human) 



66 

' P50HL-18323-04 0042 SCOR hypertension center - Blood 

viscosity and blood volume in hypertensive disease 

(human, dog) 
ROlHL-18584-03 Effects of physical forces on platelets 

(human) 
ROlHL-18672-03 Dynamic studies of clot structure 

formation (human) 

* ROlHL-188 18-04 Stereochemical mechanism of sickling of 

hemoglobin S (human) 

* ROlHL-19255-03 Evaluation of diagnostic clinical 

hemorrheology (human) 
ROlHL-19993-02 Optical detection of platelet aggregates 

(human, baboons) 
ROlHL-200 79-02 0003 Thromboresistant material • Blood 

surface interactions (human, cattle) 
ROlHL-20163-02 Competitive coronary flow in native and 

graft vessels (dog) 
ROlHL-20177-02 Effects of erythrocyte deformability on 
tissue perfusion (rats) 
■* ROlHL-20829-02 Fluid mechanics of heart valve 

prostheses (dogs, human) 
'* P60HL-20985-01 0003 Northern California sickle cell 
center - Kinetics of sickling and clinical manifestations in 
sickling disorders (human) 
ROlHL-21001-0! Protein and thrombus deposition on 

vascular grafts 
P50HL-2 1006-02 0001 Specialized center of research in 

arteriosclerosis - Clinic and core program 
POlHL-21016-02 0013 Sickle cell anemia and other 
hemoglobinopathies • Microcirculatory response to sickle 
cell treated with anti-sickling agents (rats) 
** ROlHL-21 188-02 Pulsatory water flux and endothelial cell 
desquamation 
ROlHL-21270-01 Correlation of arterial hemodynamics and 
morphology (human) 
** ROlHL-21859-01 Unsteady flow in arterial bifurcations 

(human) 
** ROlHL-22233-01 Characterization of bio-materials by 

elastic property 
** ROlHL-22338-01 Platelet adhesion and aggregation in a 
flow chamber (human) 
ROlHL-22455-01 Platelet concentration in the marginal 

layer (dogs, human) 
ROlHL-22783-01 Hemodynamic induction of Intimal 
fibromuscular lesion 
** ROlHL-23267-01 Rheology and kinetics of hemoglobin S 
gelation (human) 
ROlHL-23899-01 Flow and flexing at blood/biomaterial 
interfaces 

BLOOD STASIS 

ROlHL-01601-30 Blood coagulation and hemorrhagic 
disease (horseshoe crabs) 
** ROlHL-01648-31 Blood coagulation and hemophilia (dogs, 

swine) 
** ROIHL 01661-27 Hemostatic mechanisms (human) 
** ROlHL-022 54-23 Blood coagulation and hemorrhagic 
disease (human, animals) 
POlHL-06314-17 0047 Immunologic mechanisms in 

cardiovascular disease - Role of intravascular coagulation 
(human, animals) 
M POlHL-06350-17 Hemostasis research program project 
P01HL06350-17 0005 Hemostasis research program 
project - Purification of plasma antihemophilic factor 
(human) 
** P01HL06350-17 0015 Hemostasis research program 
project - Genetics (human) 
POlHL-06350 17 0018 Hemostasis research program 

project - Varients of factors IX (human, cattle) 
POlHL-06350-17 0019 Hemostasis research program 

project ■ Microcirculation (human, rats, rabbits) 
POlHL-06350-17 0020 Hemostasis research program 

project - Structure and function of coagulant venom 
proteases 
** ROlHL-09163-13 Control mechanisms in hemostasis 

(human) 
** R01HL-09902-13 Comparative study of coagulation and 
vascular disease (animals) 
ROlHL-10582-12 Thrombosis and hemostasis -Analysis, 

methods and standards (human, cattle, venom) 
ROIHL 11775-11 Platelet mechanisms in disease (human, 
primates) 
** ROlHL-11880-10 Physiology and pathology of blood 
platelets (human, dogs) 
R01HL13160-08 Human thrombin (also cattle) 
ROlHL-13198-21 Blood coagulation-Physico-chemical 

properties (human, cattle) 
POIHL 13262-07 0022 Arterial wall in atherosclerosis - 

Mechanisms of platelet prostaglanoin formation 
P01HL-I3737-07 0002 Assisted circulation - U-shaped 

mechanical auxiliary ventricle (dogs) 
** POlHL-13737-07 0026 Assisted circulation - Hemostatic 

mechanism (human, dogs) 
P50HL14147-08 0017 Specialized center of research in 

thrombosis - Core coagulation laboratory (human) 
P50HL-142 17-08 0055 Specialized center of research in 
thrombosis • Coagulation section-Platelet coagulant activity 
(human) 
ROlHL-14344-07 Platelet function and adenine nucleotide 

metabolism (human) 
ROIHL 1459507 Primary disorders of platelet function 
(human, rats) 



BLO 

* R01HL-14697-07 Role of platelet membranes in 
hemostasis (human) 
ROlHL-14992-07 Mechanism of thrombin action (human) 
POlHL-15195-04 0004 Program project in biological 

materials - Biological evaluation and surface interaction 
studies (dogs) 
■* ROlHL-1533506 The nature of the collagen-platelet 
Interaction (animals) 
ROlHL-15474-06 Structure and function of the 
antihemophilic factor (human, cattle) 
tfl POIHL- 15486-06 Studies on thrombosis 

ROlHL-15491-06 Blood coagulation -Platelet-plasma 
protein interaction (human) 
VI POlHL-15596-05 Coagulation, fibrinolysis, hemostasis and 
hepatitis 
ROlHL-15616-04 Platelet membrane proteins in 

aggregation (human) 
ROIHL- 15690-07 Hydrolytic enzymes of blood in health 

and disease (human, animals) 
POlHL-16387-04 0005 The blood vessel and 
thrombogenesis - Fluid engineering considerations in 
thrombogenesis 
P01HL16387-04 0006 The blood vessel and 
thrombogenesis - Mechanism of delayed vessel graft failure 
(dogs, rabbits) 
** POlHL-16387-04 0008 The blood vessel and 

thrombogenesis - Factor VIII in hemostasis (human, 
rabbits) 
** P01HL16411-04 0003 Blood systems in coagulation and 
vessel disease - Molecular events Involving the late stages 
of coagulation (rabbits) 
** POlHL-164 11-04 0005 Blood systems in coagulation and 
vessel disease • Chemical analysis of serum components 
associated with coagulation (human, animal) 
ROIHL- 1642 1-08 Determinants of RBC deformability and 

capillary flow (human, mice) 
P60HL-1726504 0001 Community blood resource center 
support - Demonstration and evaluation 
** P60HL-17265-04 0007 Community blood resource center 
support - Research -Massive transfusion and trauma 
(human) 
M POlHL-17419-04 Studies on mechanisms of hemostasis 
** POlHL-17419-04 0001 Studies on mechanisms of 

hemostasis ■ Structure and metabolism of fibrinogen 
(human) 
** POlHL-17419-04 0003 Studies on mechanisms of 
hemostasis • Characterization of fibrinogen (human) 
** P01HL17419-04 0006 Studies on mechanisms of 

hemostasis Effect of hormones, drugs and other agents 
on fibrinogen synthesis (chick) 
** POlHL-17419-04 0007 Studies on mechanisms of 
hemostasis - Structural analysis of ordered forms of 
fibrinogen (human, cattle) 
M POlHL-17430-05 Control of coagulation 
** POlHL-17430-05 0001 Control of coagulation • Porcine 
von Willebrand's disease 
P01HL17430 05 0002 Control of coagulation - Isolation 

of ristocetin-von Willebrand factor (swine) 
POlHL-17430-05 0005 Control of coagulation - The 

activation of prothrombin (human, cattle, dogs) 
POlHL-1743005 0007 Control of coagulation - Platelet 
adhesion, aggregation, ultrastructure in flowing blood 
(human, animals) 
ROlHL-17462-03 Role of glycosphingolipids in platelet 

aggregation (rats, human, dogs) 
R01HL17513-04 Role of PF-4 in detecting and promoting 

thrombosis (human, primates) 
ROlHL-17525-03 Molecular basis of collagen-platelet 

interaction (human, rat) 
ROlHL-17729-04 Stimulus-response coupling in platelets 

(human) 
ROlHL-17930-03 Platelet membrane function-Assessment 
and application (animals) 
** ROlHL-18030-04 The role of contractile proteins in 
platelets (human, rabbits) 
ROlHL-18321-03 Fluid shear or magnetic alignment of 

blood components (human) 
ROlHL-18502-03 Enzymatic regulation of platelet function 
(human) 
M POlHL-18576-03 Thrombosis research program project 
POlHL-18576 03 0004 Thrombosis research program 
project - Mechanism and control of collagen-platelet 
interaction 
** POlHL-18576-03 0007 Thrombosis research program 
project - Relationships between coagulability and 
thrombosis (human, animals) 
** P01HL18576-03 0009 Thrombosis research program 

project ■ Biology of factor VII (human, rabbits, cattle) 
POlHL-18576-03 0012 Thrombosis research program 

project - Synthetic anticoagulant and thrombolytic agents 
(dogs) 
** R01HL1858603 Role of platelet lipids in hemostasis and 
thrombosis (human) 
ROlHL-18650-03 Platelet collagen interaction (human) 
R01HL1881503 Surgical vascular disorders (human. 

dogs) 
POlHL-18827-02 0007 Platelet vessel wall interactions in 
thrombogenesis ■ Biochemistry and role factor V in 
thrombogenesis (human, cattle) 
P50HL18828-03 0001 Specialized center of research in 
thrombosis - Membrane biology and hemostasis (human) 

(contd) 



'Eidudes routine methodotogy OR covers only general projects which preclude 
"Oriented significantly to above subject. 



Indexing at the specific level. 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



•lO 



67 



PbOHl 18828 03 000? Sptclaliitd centitr ol tmaacch in 

thcomboils Endothelial call biology (human, |uin«a pig) 
RUIHl 18834 04 Mttaldapandent complei loimation in 

blood coagulation (human, cattle) 
ROIHL I893S03 Platelets. Iibnnogen. soluble libiin 

interaction (human) 
ROIHI 192;003 Ellects ol eiythiopoiesis on plilelels and 

hemostasis (rats) 
ROIHI 19282 03 Regulation ol the activation of human 

ladoi X 
ROIHL 1999602 Role ol membrane proteins in platelet 

(unction (human, rabbits) 
ROIHI 20014 02 Radioimmunoassay of hyper and 

hypocoagulable states (rabbits) 
ROIHL 20106 02 Coupling ol platelet conliactile proteins 

to fibrin (human) 
ROIHI 20?87 02 Thromboxanes and prostaglandins" 

Biochemical pharmacology (rabbits, human) 
ROIHL 20846 02 Purification of bovine plasminogen 

proactivator 
ROIHL 20956 02 Early events following stimulation of 

human platelets 
POIHL 21016 02 0013 Sickl« cell anemia and othei 

hemoglobinopathies Microcirculalory response to sicKle 

cell treated with anti sicKling agents (rats) 
R01HL2111301 

(cattle) 



Physiologic pharmacology and its 
Olood theology in coronary hearl 



Control mechanisms in coagulation 

Ion and Shydroxytryptamine transport by 

Structure of factor VlllVon Willebrand 



ROlHL-21217-01 

platelets 
R01HL2137901 

protein (human) 
R01HL2146002 Lipoproteins, hemostasis and 

atherosclerosis (human, rabbits) 
ROIHL 2148701 Molecular characterization of 

Glanzmann's thrombasthenia (human) 
R23HL-21490-02 Studies of enzymes in human platelet 

membranes 
ROlHl-21988 01 

chemotaxis 
ROlHL-22289-01 

(rabbits) 
ROlHl-22355-01 



Biochemistry of human platelet 
Endothelial cell mediated fibrinolysis 



Purification, structure and function of 
factor VIII (human) 
ROlHL-2250201 ' Role of phosphoinositides in human 

platelet secretion 
ROlHL-22583-02 Ultrastructural study of endothelium in 

thrombosis (human) 
POlHL-2260201 0001 Pathophysiology of the 

endothelium • Platelet-endothelial interactions in vitro 
(human, cattle) 
ROlHL-22671-01 Removal of senescent and stored human 

red cells 
ROlHL-2295501 inetics of prothrombin activation 
BLOOD SUBSTITUTES 
** ROlHL-1552006 Total blood replacement by fluorocarbons 

and polyols (rats) 
** R01HLI6643-02 Fluorocarbon emulsions as artificial 
blood (animals) 
ROlHL-17705-04 Kallikrein-kinin system in hypertension 
(human, rats, dogs) 
** ROlHL-17794-03 Chelating agents as blood substitutes 
** ROlHL-17844-04 Artificial blood substitutes-02-binding 

iron chelates (human, mammals) 
** ROlHL-23 120-01 Chelating agents as blood substitutes 

BLOOD SUBSTITUTES, PLASMA SUBSTITUTES 

POIHLI 1678-11 0034 Cardiovascular dynamics and their 

control - Renal function curves in intact dogs 

ROlHL-14693-07 Survival value of physiological responses 
to hypoxia (dogs) 

R01H1.-18010-04 Capillary transport of large molecules 
(dogs, sheep) 

BLOOD SUGAR 

SEE CARBOHYDRATE BALANCE, BLOOO SUGAR 
BLOOD SUPPLY 

SEE CARDIOVASCULAR SYSTEM. BLOOD SUPPLY 
BLOOO SUPPLY OF NEOPLASMS 

SEE NEOPLASMS VASCULAR SUPPLY 
BLOOD (HEMATOLOGIC) TESTS* 

ROIHL 10567 12 Erythropoietin-Immunoassay and 
characterization (dogs) ' 

** P50HL-14230-07 0097 A/S SCOR -Lipids, atherosclerosis 
and thrombosis - Studies of circulating platelet aggregates 
(human) 
P60HL-15158-07 0008 Comprehensive sickle cell center ■ 

Core laboratory of the center 
P60HL- 17265-04 0001 Community blood resource center 

support - Demonstration and evaluation 
** ROlHL-18256-01 Optical properties of platelets and 
erythrocytes (rabbits, dogs, human) 

BLOOD (HEMATOLOGIC) TESTS, BLOOD CELL 
COUNT* 

ROlHl-03181-21 0025 Hemodynamics as applied to 

surgical problems - Vascular stenosis (dogs) 
ROlHL-11152-12 Vascular physiology (human, cats, dogs) 
ROlHL-12530-10 Emphysema-Respiratory function in 
diseas* (human, dogs, rats) 



** POIHI 12/38 10 0069 

ilinical applications 

disease (dogs) 
POIHL 149850/ 0013 Adaptation to hypoxia Chronic 

mountain sickness (man) 
ROIHL 1504/ 06 Digital computer analysis ol the 

electrocardiogram (human) 
P60HL 15169 05 0019 Support for center for sicklo cell 

disease Central screening and reference laboratory 
ROIHL 15520 06 Total blood replacement by fluorocarbons 

and polyols (rats) 
POIHL 16851 04 0009 Human red cell membrane in 

health and disease Blood cell properties in circulatory 

regulation (dogs, rabbits) 
POIHL 18208 04 0003 Center lor the study of blood cell 

rheology Bone marrow microcirculation (rats, mice) 
ROIHL 18321 03 Fluid shear or magnetic alignment of 

blood components (human) 
P50HL 19153 02 0005 SCOR Pulmonary edemas Eitology, 

pathogenesis Lung vascular permeability measured by 

indicator dilution methods (sheep) 
ROIHL 19203 03 Surgical approach to congenital heart 

diseases (dogs, primates) 
ROIHL 19270 03 Effects of erythropoiesis on platelets and 

hemostasis (rats) 
ROIHL 19993 02 Optical detection of platelet aggregates 

(human, baboons) 
POIHL 22163-01 0002 Surface thrombogenesis 

Mechanisms and prevention Laser scattering detection ol 

microemboli in blood How (baboons) 

BLOOD (HEMATOLOGIC) TESTS, BLOOD 
SEDIMENTATION, ERYTHROCYTE* 

R01HL18321 03 Fluid shear or magnetic alignment ol 
blood components (human) 

BLOOD (HEAAATOLOGIC) TESTS, OSMOTIC 
FRAGILITY* 

R01HL18660-03 Neurotransmitter receptors in human 

erythrocytes 
ROlHL-20882-02 Interactions ol plasma lipoproteins with 

erythrocytes (Rhesus, human) 

BLOOD TOXICOLOGY 

SEE ALSO IMMUNOLOGICAL TESTS AND IMMUNOASSAY, 
HEMAGGLUTINATION* 
NOlHB-22919-08 Hemoglobin carbamylation in the 

treatment of sickle cell anemia (human, dogs) 
NOIHB 22922 08 Develop effective therapy for sickle cell 

disease (human, dogs) 
POlHL-09011-15 0022 A research and resource program 

in blood - Ciyopreservation of blood components (human) 
R01HL23654-01 Selected topics on blood transfusion 

(rabbits, human) 
NOlHV-32950-08 Blood compatible poly-electrolytes 
NOlHV-32953-10 Materials compatible with blood (dogs) 

BLOOO TOXICOLOGY, BACTEREMIA-SEPTICEMIA 

" ROlHL-02363-20 Kinetics of water and electrolytes in 
shock (dogs, rats) 
ROlHL-03181-21 0029 Hemodynamics as applied to 
surgical problems - Indocyanine green clearance for 
estimation of hepatic blood flow (human) 
POlHL-06350-17 0019 Hemostasis research program 

project - Microcirculation (human, rats, rabbits) 
ROlHL-08659-14 Myocardial performance and metabolism 
in the newborn (sheep) 
M POlHL-08682-15 Regulation of the cardiovascular system 
** POlHL-08682-15 0019 Regulation of the cardiovascular 
system - Hepatic immunophysiology and host-defense in 
shock (rat, dog, human) 
** POlHL-08682-15 0020 Regulation of the cardiovascular 

system - Hepatic metabolic basis of shock (rat) 
** POlHL-08682-15 0021 Regulation of the cardiovascular 

system - Hypoglycemia in pathogenesis of shock (dog) 
** P01HL-08899-I4 0010 Tolerance to respiratory gases in 

health and disease • High oxygen pressure in septic shock 
(human) 
** ROlHL-12421-10 Pathophysiology of circulatory shock 
(dogs, baboons) 
P50HL-151 62-07 0021 Comprehensive sickle cell center - 

Pneumococcal vaccine in sickle cell disease (children) 
P60HL15169-05 0009 Support for center for sickle cell 

disease - Infections in sickle cell anemia (human) 
ROlHL-15593-05 Prolonged extracorporeal cardiopulmonary 

support (rats, sheep, rabbits) 
P01HL164 11-04 0004 Blood systems in coagulation and 

vessel disease - Platelets reactions in vascular injury 
(human, animals) 
ROlHL-16642-05 Biochemistry and pathophysiology of 

plasma kallikrein (human, animals) 
POlHL-16769-05 0002 Pathobiologic and host defense 

reactions in the lung - Pathogenesis of complement 
dependent injury to the lungs (rabbits) 
** ROlHL-17479-04 Blood storage-The production of 

cardiotoxic material (dogs, human, swine) 
** ROlHL-17751-03 Experimental endocarditis (rabbits) 
•* P01HL-17812-04 0007 Thrombosis and plasma proteins ■ 

Blood components-Response to endotoxin (dogs, baboons) 
R01HL19030-03 Tissue protection during circulatory 
interruption (dogs) 



•Excludes n)utine melhodotogy OR covers only general projects which preclude indexing 
"Wented significantly to above subject. 



at the specific level. 



M Grant has subprojects descnbing specific research aspects 
See Appendix for investigator's name and grant number 



MO 

P50m 19151 07 0001 SCOR Pulmonary cdamai Filoloty. 

pathu|tn«ii« Protlaflandins and lh< lung circulation 

(sheep) 
P50HI 19153 02 0007 StOR Pulmonary tdtmai (itolofy. 

palhogenesis lung lluid dynamic* Clattiol mediatoit 

and their inhibilor\ (sheep) 
" P50HI 19153 07 0001 SCOR Pulmonary edemai Fitoloiy. 

pathogenesis Possible inhibitors ol mediator rtleai* and 

pulmonary vascular response (sheep) 
ROIHI 19374 03 Pharmacology ol kinini in cardiovascular 

disease (rats, rabbits) 
ROIHI 196/3 03 Surgical aspects of shock and hypoxia 

(dogs, monkeys, rals) 
ROIHL 19/75 03 Complement inducwl pulmonary injury 

(dogs, rabbits, sheep) 
*• ROIHL 1997/02 Genesis of circulatory shock by 

pancreatic peptides (cats, dogs) 
ROIHI 203/1 02 Intravascular redistribution of blood 

volume (dogs) 
ROIHL 20787 02 Thromboxanes and prostaglandins 

Biochemical pharmacology (rabbits, human) 
R73HL21116 02 Mechanisms of membrane and tissue 

damage in lung (dogs, rabbits) 
ROIHL 2117202 Regional oxygen consumption of heart 

and other organs (animals) 
ROIHL 2243502 Pulmonary alveolar capillary permeability 

characteristic (dogs) 
ROIHL 22520 01 Pulmonary vascular response to group B 

Streptococci (human, mammals) 
** R01HL2311401 Control of platelet aggregation in shock 

(dogs, rabbits) 
R01HL2361801 Substrate metabolism in isolated 

myocytes in shock (dogs, rats, guinea pigs) 

BLOOD TOXICOLOGY, HEMOLYSINS 

SEE ALSO BLOOD CELLS. ERYTHROCYTES, HEMOLYSIS 
SEE ALSO PHOSPHOLIPIDS. PHOSPHOGLYCERIDES. 
LYSOLECITHIN 
ROIHL 19532-01 Oxygen toxicity in the red cell (human) 

BLOOD TOXICOLOGY, HEMOTOXINS 

** ROlHL-17479-04 Blood storage-The production ol 
cardiotoxic material (dogs, human, swine) 

BLOOD TRANSFUSION 

SEE ALSO BLOOO GROUP INCOMPATIBILITY 

SEE ALSO BLOOD SUBSTITUTES 

SEE ALSO CARDIOVASCULAR SURGERY, EjaRACORPOREAL 
CIRCULATION, CROSS CIRCULATION 
NOlHB-62963-03 International bone marrow transplant 

registry 
NOlHB-62964-03 International bone marrow transplant 

registry 
ROlHL-0869615 0011 Orthotopic heart transplantation - 

Transplantation immunology-lmmunodepressive factor 

(human, dogs) 
POlHL-09011-15 0017 A research and resource program 

in blood - Operations research laboratory 
P01HL-090I1 15 0022 A research and resource program 

in blood - Cryopreservation of blood components (human) 
ROlHL-10582-12 Thrombosis and hemostasis-Analysis, 

methods and standards (human, cattle, venom) 
** P01Hm310-12 0095 Mechanisms of cardiovascular 

disease - Blood and transfusion disorders (human, rats, 

monkeys) 
P60HL 15158-07 0004 Comprehensive sickle cell center - 

Expression of abnormal hemoglobin synthesis in the 

neonate and young child 
P60HL-15158-07 0012 Comprehensive sickle cell center - 

Clinical seivices-Pediatric patients 
** P50HL-15160-07 0011 Center for sickle cell disease - 

Study of human sickle cells in an animal model (rats) 
** P60HL-15160 07 0014 Center for sickle cell disease - 

Replacement therapy of opsonin deficiency in sickle cell 

anemia (children) 
P60HL-16008-06 0014 Wayne State University 

comprehensive sickle cell center - Zinc and red blood cell 

metabolism in sickle cell anemia (rats, human) 
ROlHL-16626-05 Studies of antibodies to antihemophilic 

factors (human, rabbits) 
** ROlHL-16931-04 Red cell storage and transfusion 

(human, animals) 
M P60HL-1 7265-04 Community blood resource center support 
P60HL-17265-04 0001 Community blood resource center 

support - Demonstration and evaluation 
P60HL-17265-04 0007 Community blood resource center 

support ■ Research-Massive translusion and trauma 

(human) 
P60HL 17265-04 0008 Community blood resource center 

support - Research-Blood genetic markers as biological 

probes (human) 
POlHL-17430-05 0001 Control of coagulation - Porcine 

von Willebrand's disease 
ROlHL-17479-04 Blood storage-The production of 

cardiotoxic material (dogs, human, swine) 
POlHL-18646-03 0004 Studies basic to heart 

transplantation - Presensitization -Detection, incidence and 

clinical significance 
ROlHL-19898-03 Desferrioxamine therapy in thalassemia 

(dogs. rats, children) 
** ROlHL-19946-03 Reduction of iron overload in 

thalassemia (children, rabbits, dogs, monkeys) 

(contd) 



BLO 

** ROlHL-19961-03 Management of hemosiderosis in 

thalassemia (childrenn adults) 
** R01HL19993-02 Optical detection of platelet aggregates 
(human, baboons) 
ROlHL-20000-03 Iron overload in homozygous beta 

thalassemia (human) 
ROlHL-20016-03 Chelator development for thalassemia 

(human, mice, rats, dogs, monkeys) 
ROlHL-20141-02 Biochemical approaches to management 

of iron overload (human, sheep, dogs) 
P60HL-20985-01 0007 Northern California sickle cell 

center - Immunohematologic abnormalities in sickle cell 
anemia (human) 
ROlHL-22671-01 Removal of senescent and stored human 
red cells 
** ROlHL-22838-01 Post-transfusion hepatitis in newborn 
children 
P60HL-2328201 0002 Comprehensive hospital/community 
sickle cell center - Clinical evaluation of alternate 
pathaway of compliment activation 
** ROlHL-23654-01 Selected topics on blood transfusion 

(rabbits, human) 
BLOOD TRANSFUSION, AUTOTRANSFUSION 
ROlHL-16656-06 Left ventricular function in exercise 

(dogs) 
ROlHL-18815-03 Surgical vascular disorders (human, 

dogs) 
ROlHL-207 16-02 Freezing and electromagnetic thawing of 
platelets (rats) 
** ROlHL-22005-01 Intermittent retroperfusion of ischemic 

myocardium (dogs) 
BLOOD TRANSFUSION, BLOOD DONORS 

NOlHB-62970-02 Collection, function and transfusion of 

granulocytes 
NOlHB-6297305 Collection, function and transfusion of 

granulocytes 
P01HL-0901M5 0017 A research and resource program 
in blood ■ Operations research laboratory 
** POlHL-09011-15 0018 A research and resource program 
in blood ■ Hepatitis B in normal populations -Epidemiology, 
risk factors and transmission 
POlHL-09011-15 0020 A research and resource program 
in blood - Passive immunization in the prevention of 
transmission of hepatitis B (human) 
P60HL15996-06 0008 Cincinnati comprehensive sickle 
cell center ■ Patient care (children, adults) 
** P60HL-17265-04 0001 Community blood resource center 

support ■ Demonstration and evaluation 
ROlHL-23654-01 Selected topics on blood transfusion 
(rabbits, human) 
BLOOD TRANSFUSION, EXCHANGE 

SEE ALSO BLOOD TREATMENT, WHOLE BODY PERFUSION 
(BLOOD REPLACEMENT) 
** P50HL-15061-07 0013 Response of lung to injury ■ 

Exchange transfusion in infants with respiratory distress 
syndrome (human, sheep) 
R01HL15215-06 Role of complement in intravascular 
coagulation (rabbits, mice) 
** P60HL-16C0505 0021 Comprehensive sickle cell center - 
Management of pregnancy in sickle cell anemia (human) 
P60HL-16005-05 0022 Comprehensive sickle cell center - 

Regulation of erythropoiesis in patients with sickle cell 
anemia 
POlHL-19737-02 0006 Cellular and molecular aspects of 
respiratory physiology - Tissue oxygenation and 
mitochondrial respiratory activity (sheep) 
ROlHL-20337-02 Thromboembolic diseases (human) 

BLOOD TRANSFUSION, LEUKOCYTE 
TRANSFUSION 

** NOlHB-62970-02 Collection, function and transfusion of 

granulocytes 
** NOlHB-62971-03 Collection, function and transfusion of 

granulocytes 
** NOlHB-62972-05 Collection, function and transfusion of 

granulocytes 
" NOlHB-6297305 Collection, function and transfusion of 

granulocytes 
** P60HL-17265-04 0009 Community blood resource center 

support Research -Developing granulocyte transfusion 
therapy (human, rabbit) 
R23HL-21997-01 Pulmonary immunopathology in the 
compromised host (guinea pigs) 
BLOOD TRANSFUSION, PLATELET TRANSFUSION 
P01HL1131012 0095 Mechanisms of cardiovascular 
disease - Blood and transfusion disorders (human, rats, 
monkeys) 
ROlHL-13629-08 Hemorrhagic diseases (human) 
R01HL14637-05 Thrombopoietin -Immunoassay and 
characterization (mice) 
" P60HL1 7265-04 0006 Community blood resource center 

support • Research -Evaluation of platelet transfusions 
(human, dog) 
ROlHL-207 16-02 Freezing and electromagnetic thawing of 

platelets (rats) 
ROlHL-2078802 Preservation of human platelets for 

transfusion 
ROlHL-20818-02 Platelet storage at 22 degrees C 
(human) 



68 

** ROlHL-2085602 Platelet transfusions -Usage and 

complications (human) 
BLOOD TREATMENT, BLOOD FILTERS 

R01HL12839-09 Flow, transport and membrane 

phenomena in blood (human) 
P60HL17265-04 0009 Community blood resource center 

support - Research -Developing granulocyte transfusion 
therapy (human, rabbit) 
ROlHL-19993-02 Optical detection of platelet aggregates 
(human, baboons) 
** ROlHL-205 54-02 Memory-alloy-filters for venous emboli 

(dogs) 
BLOOD TREATMENT, BLOOD FILTERS, VENA 

CAVA FILTERS 
** POlHL-11414-11 0027 Thrombosis and atherosclerosis 

program ■ Thermal memory wire filter to prevent pulmonary 
embolism (human, dogs) 
BLOOD TREATMENT, HEMODIALYSIS 

SEE ALSO KIDNEY PROSTHESIS, ARTIFICIAL KIDNEY 
** NOlHB-229 19-08 Hemoglobin carbamylation in the 

treatment of sickle cell anemia (human, dogs) 
** NOlHB-22922-08 Develop effective therapy for sickle cell 

disease (human, dogs) 
** NOlHB-62962-02 Red cell distributions in cyanate-treated 
blood (human, sheep) 
R01HL00340-29 Electrolyte disturbance in cardio-renal 
disease (human, dogs, rats) 
** POlHL-06370-17 0013 Cardiopulmonary and renal 
pathology research center - Morphologic analysis of 
vascular prosthesis (human, dogs) 
POlHL-0683517 0064 Cardiovascular disease - Studies 

in atherosclerosis (human, animals) 
P01HL0901M5 0020 A research and resource program 

in blood - Passive immunization in the prevention of 
transmission of hepatitis B (human) 
POlHL-090 11-15 0023 A research and resource program 

in blood ■ Evaluation of hepatitis B vaccine in endemic 
settings (human) 
P01HL1131012 0084 Mechanisms of cardiovascular 

disease ■ Evaluation of cardiac function in chronic renal 
failure (human) 
ROlHL-12839-09 Flow, transport and membrane 

phenomena in blood (human) 
ROlHL-14092-07 Homeostatic regulation of plasma choline 

(rats, dogs, chickens) 
R01HL14133-08 Intrarenal regulation of sodium 

reabsorption (dogs, hamsters, rats) 
R01HL1512405 Genesis of hypertension in renal disease 
(human, dogs) 
** R01HL1566806 Extracorporeal respiratory gas exchange- 
A new approach (dogs) 
R01HL162 19-05 Mechanisms of atherogenesis in chronic 

uremia (human, rats) 
ROlHL-18923-02 Steroid-induced hyperlipidemia and 

hypertension (human, rats) 
ROlHL-19428-03 Role of angiotensin sensitivity in renin 
release (human) 
** ROlHL-20141-02 Biochemical approaches to management 
of iron overload (human, sheep, dogs) 
ROlHL-201 77-02 Effects of erythrocyte deformability on 

tissue perfusion (rats) 
ROlHL-2262701 An inhibitor of platelet adhesion to 

artificial organs (human) 
ROIHL 23899-01 Flow and flexing at blood/biomaterial 
interfaces 
BLOOD TREATMENT, LEUKAPHERESIS 

P60HL17265-04 0009 Community blood resource center 

support - Research -Developing granulocyte transfusion 
therapy (human, rabbit) 
BLOOD TREATMENT, PLASMAPHERESIS 

POlHL-1141411 0033 Thrombosis and atherosclerosis 

program - Human coumarin-induced prothrombin 
P01HL17430-05 0001 Control of coagulation - Porcine 

von Willebrand's disease 
POlHL-1743005 0002 Control of coagulation - Isolation 
of ristocetin-von Willcbrand factor (swine) 

BLOOD TREATMENT, PLATELETPHERESIS 

P60HL-17265-04 0006 Community blood resource center 

support ■ Research-Evaluation of platelet transfusions 
(human, dog) 
BLOOD TREATMENT, WHOLE BODY PERFUSION 

(BLOOD REPLACEMENT) 
** R01HL-I5520-06 Total blood replacement by fluorocarbons 

and polyols (rats) 
** R01HL17844-04 Artificial blood substitutes -02-binding 
iron chelates (human, mammals) 

BLOOD TYPES 

SEE BLOOD GROUPS 

BLOOD VESSELS 

SEE CARDIOVASCULAR SYSTEM, BLOOD VESSELS (GENERAL) 

BLOOD VESSELS DISORDERS (GENERAL) 

SEE CARDIOVASCULAR DISORDERS, VASCULAR DISORDERS 
(GENERAL) 



BLO 

BLOOD VESSELS NEOPLASMS 

SEE NEOPLASMS OF CARDIOVASCULAR SYSTEM 
BLOOD VESSELS PRESERVATION 

SEE CARDIOVASCULAR TISSUE PRESERVATION 

BLOOD VESSELS PROSTHESIS 

SEE CARDIOVASCUUR PROSTHESIS, BLOOD VESSELS 
PROSTHESIS 
BLOOD VESSELS RESTORATION 

SEE CARDIOVASCULAR SURGERY, BLOOD VESSELS 
RESTORATION 
BLOOD VESSELS SHUNTS ARTERIOVENOUS 
ABNORMAL 
SEE CARDIOVASCULAR DISORDERS, ARTERIOVENOUS SHUNTS 
ABNORMAL 
BLOOD VESSELS SHUNTS ARTERIOVENOUS 
NORMAL 
SEE CARDIOVASCUUR SYSTEM. ARTERIOVENOUS 
ANASTOMOSIS NORMAL 

BLOOD VESSELS SHUNTS COLLATERAL 
CIRCULATION NORMAL 

SEE CARDIOVASCULAR SYSTEM, BLOOD SUPPLY, COLUTERAL 
CIRCUUTION 
BLOOD VESSELS SHUNTS DUCTUS ARTERIOSUS 
EMBRYONIC 

SEE CARDIOVASCULAR SYSTEM, DUCTUS ARTERIOSUS 
EMBRYONIC 
BLOOD VESSELS SHUNTS SURGICAL 

SEE CARDIOVASCUUR SURGERY, CARDIOVASCUUR SHUNTS 
BLOOD VESSELS TRANSPLANTATION 

SEE CARDIOVASCUUR TRANSPUNTATION, BLOOD VESSELS 
TRANSPUNTATION 
BLOOD VISCOSITY-VISCOELASTICITY 

SEE ALSO BLOOD PROTEINS DISORDERS, HYPERVISCOSITY 
SYNDROME 
*• ROlHL-03181-21 0025 Hemodynamics as applied to 
surgical problems - Vascular stenosis (dogs) 
ROlHL-08977-14 Quantitation of flow and solute flux in 

microvessels (cats, rats) 
ROlHL-1190112 0017 Effects of metabolic surgery on 
the hyperlipidemias • Membrane permeability, blood 
viscosity, oxygen uptake -Rheology studies (rabbits) 
ROlHL-12256-15 Polymerization of sickle-cell hemoglobin 

(human) 
POlHL-12738-10 0069 Physiologic pharmacology and its 

clinical applications ■ Blood rheology in coronary heart 
disease (dogs) 
ROlHL-12775-08 Cerebral microcirculation (mice) 
P60HL 15157-07 0011 Comprehensive center for sickle 

cell disease ■ Development of specific anti-sickling 
compound (human) 
P60HL-15162-07 0019 Comprehensive sickle cell center ■ 

RBC-Blood rheology in sickle cell anemia and related 
disorders (human, animal) 
** P60HL1599606 0010 Cincinnati comprehensive sickle 
cell center - Whole blood viscosity in sickle cell anemia 
(human) 
P01HL16387-04 0005 The blood vessel and 
thrombogenesis ■ Fluid engineering considerations in 
thrombogenesis 
ROlHL-1642108 Determinants of RBC deformability and 

capillary flow (human, mice) 
POlHL-1683304 0008 Hemoglobin and red cell system in 
hemoglobinopathies - Membrane associated phenomena in 
SS disease 
POlHL-16833-04 0009 Hemoglobin and red cell system in 
hemoglobinopathies - Rheological studies of sickled cells 
(human) 
M P01HL16851-04 Human red cell membrane in health and 

disease 
•* POlHL-16851-04 0001 Human red cell membrane in 
health and disease - Rheology of erythrocyte membrane 
(human, amphiuma) 
POlHL-1685104 0003 Human red cell membrane in 

health and disease ■ Modeling membrane mechanics and 
blood rheology 
ROlHL-16927-05 Structure and function of normal and 

abnormal hemoglobin (human) 
R01HL16938-05 Effect of physical forces on blood (dogs, 

human) 
R01HL17408-03 Fresh blood rheology-Relation to 

cardiovascular risk (human) 
POlHL-1820804 0004 Center for the study of blood cell 

rheology - Splenic microcirculation (rats, mice) 
POlHL-18208-04 0005 Center for the study of blood cell 

rheology RBC deformability and capillary flow 
interrelations (human, mice) 
POlHL-18208-04 0006 Center for the study of blood cell 

rheology - Analysis of flow m arterioles and capillaries 
(human) 
** P50HL18323-04 0042 SCOR hypertension center ■ Blood 

viscosity and blood volume in hypertensive disease 
(human, dog) 
R01HL18467 03 Fingertip blood flow in normals and 
Raynaud's disease (human) 

(contd) 



•Ettludes iDutine nethodotogy OR covers only general projects which preclude 
"Oiiented significanthf to above subject. 



ndexing at the specific level. 



M Giant has subproieds describing specific research aspects. 
See Appendix tor Investigatot's name and grant number. 



Characterisation of bio materials by 



■lO 

" ROIHL I8i84 03 EflKts of physlcil force] on plotolits 

(human) 
ROIHL 18672 03 Dynamic studlts ot clot structure 

formation (human) 
ROIHL 19203 03 Surgical approach to conienilal heart 

diseasts (dO|S. primates) 
ROIHL 192S5 03 Evaluation ol diagnostic clinical 

htmorrhaology (human) 
ROIHL 20106 02 Coupling ol platelet contiactile proteins 

to fibrin (human) 
P60HL 20985 01 0003 Northern Calilomia sickle cell 

center Kinetics ol sicKlmg and clinical manileslations in 

sickling disorders (human) 
POIHL 21016 02 0013 Sickle cell anemia and othei 

hemoglobinopathies Microcirculatory response to sickle 

cell treated with antisickling agents (rats) 
ROIHL'22223-OI The cardio pulmonary {unction (dogs. 

models) 
** R01HL2223301 

elastic property 
ROIHL 224SS'01 Platelet concentration in the marginal 

layer (dogs, human) 
*• ROlHL-2326701 Rheology and kinetics of hemoglobin S 

gelation (human) 
" ROlHL-2390001 Mechanical measurement ol cell 

membrane viscosity (human) 

BIOOD VOLUME 

SEE CARDIOVASCULAR FUNCTION. BLOOD VOLUME 
BLOODLETTING 

POIHL 1131012 0095 Mechanisms of cardiovascular 
disease Blood and transfusion disorders (human, rats, 
monkeys) 

BLOOM'S SYNDROME 

SEE GENETIC DISORDERS. BLOOMS SYNDROME 
BODY CAVITIES, DIAPHRAGM 

SEE ALSO BODY CAVITY DISORDERS, DIAPHRAGMATIC HERNIA 
SEE ALSO NERVOUS SYSTEM, SPINAL NERVES. PHRENIC 
NERVE 
** ROlHL-04651-19 Remote stimulation by radio-frequency 
transmission (dogs, human) 
POlHL-14580-07 0003 Program project in respiratory 

mechanics - Chest wall mechanics and respiratory control 
(human, dogs) 
R01HL1771504 Respiratory muscle afferents in 

respiratory control (cats) 
ROlHL-18007-05 Neural mechanisms controling motor act 

of breathing (cats, human) 
POlHL-21584-02 0004 Respiratory mechanics in normal 

and abnormal states - Effects of anesthesia on respiratory 
mechanics (dogs) 
** R13HL-22525-0I International symposium on the 

diaphragm (Virginia) 
** ROlHL-22844-01 Phrenic nerve pacing-Noninvasive 

diaphragm analysis (human, dogs) 
" R0IHL-23985-0I Role of the diaphragm in regional lung 
mechanics (dogs) 

BODY CAVITIES, MEDIASTINUM 

POlHL-21584-02 0004 Respiratory mechanics in normal 

and abnormal states - Effects of anesthesia on respiratory 
mechanics (dogs) 

BODY CAVITIES, MESENTERY 

ROlHL-06736-18 Biogenic-mechanical factors in 

microcirculation (rats, gerbils) 
ROlHL-10881-13 Structure and function of 

microcirculation (hamsters, rats, cats, dogs) 
R01HL-1249310 Bioengineering analysis of microvascular 

function (cats, rabbits) 
ROlHL-13437-09 Physical and mechanical parameters in 

the microcirculation (animals) 
** P01HL-I7421-05 0003 Regulation and exchange in the 

microcirculation - Transcapillary fluid exchange in rat 

intestinal muscle, mucosa, and mesentery 
P01HL1742105 0004 Regulation and exchange in the 

microcirculation - Localization of flow regulation in the 

microcirculation (cats, human) 
POlHL-17871-04 0009 Kidney, sodium, cardiac output, 

arterioles and hypertension • Kidney, sodium, cardiac 

output, arterioles and hypertension 
ROlHL-18831-03 Microscopy of spontaneously hypertensive 

arterial lesion (rats) 
** POlHL-20581-01 0004 Vascular neuroeffector 

mechanisms in health and disease - Neuroeffector 

characteristics of mesenteric and pulmonary blood vessels 

(rabbits) 
R01HL-2I351-02 Renal and vascular control by 

sympathetic ganglia (animals) 
** ROlHL-22561-01 Hormonal control of mesenteric 

circulation (cats) 

BODY CAVITIES, OMENTUM 

ROlHL-12493-10 Bioengineering analysis of microvascular 
function (cats, rabbits) 

BODY CAVITIES, PERITONEUM 

R23HL-21 134-02 Immune function and fibrogenesis in 
silicosis (guinea pigs) 

BODY CAVITIES, PLEURAL CAVITY 

SEE ALSO BODY REGIONS, THORAX 



ROIHI 14495 05 
(mnminnM 



69 

Solid jind tliudural mechanics ol lung) 



Dietary effects on cholesterol metabolism 
Effect of exercise upon the hypertensive 



BODY CAVITY DISORDERS, DIAPHRAGMATIC 
HERNIA 

ROIMI 15526 05 Respiratory mechanics in children 
ROIHI 19839 09 Factors in youth predisposing to chronic 
diseases (lormoi college students) 

BODY CAVITY DISORDERS, PERITONEAL 

ROIHL 131/2 10 Post trauma lung mechanics and fluid 
exchange (human, dogs, monkeys) 

BODY CAVITY DISORDERS, PERITONEAL 
EFFUSIONS, ASCITES 

ROIHI 18020 04 Splanchnic hemodynamics in man 
ROIHL 22051 01 Role of angiotensin II in vasopressin 
release (human) 

BODY CAVITY DISORDERS, PLEURAL 

POIHL 06312 17 0050 Surgical cardioloey Prevention ol 

pericardial and pleural adhesions by silicone oil (dogs) 
ROIHL 13172 10 Post trauma lung mechanics and fluid 

exchange (human, dogs, monkeys) 
POIHL 21584 02 0002 Respiratory mechanics in normal 

and abnormal states Lung mechanics Regional 

delormation and ventilation (dogs) 

BODY CAVITY DISORDERS, PLEURAL, 
PNEUMOTHORAX (GENERAL) 

SEE ALSO RESPIRATORY DISORDERS, ATELECTASIS 
ROIHL 13172 10 Post-trauma lung mechanics and fluid 
exchange (human, dogs, monkeys) 
** R23HL-21050 02 Mechanisms of re-expansion pulmonary 
edema (rabbits) 

BODY CAVITY DISORDERS, PLEURAL EFFUSIONS 

** POlHL-06285-18 0145 Cardiovascular-respiratory 

physiology and biochemistry - Pulmonary, pleural and 

systemic microcirculation (animals) 
** ROlHL-19678-01 Quantification of intrathoracic fluid by 

impedance (human, dogs) 
POIHL 19717-02 0043 Response of the lung to injury - 

Asbestosis as a model of usual interstitial pneumonia 

(human) 
R23HL-21050-02 Mechanisms of re-expansion pulmonary 

edema (rabbits) 

BODY COMPOSITION 

ROlHL-03299-21 

(rats, rabbits) 
R01HL-21578-01 

adolescent 

BODY FLUIDS (AND RELATED SUBSTANCES) 

SEE ALSO BIOLOGICAL TRANSPORT, FLUID EXCHANGE AND 
TRANSPORT 

SEE ALSO BLOOD AND RE SYSTEM, BLOOD* 

SEE ALSO BLOOD AND RE SYSTEM, LYMPH 

SEE ALSO CELL FLUIDS 

SEE ALSO EAR, LABYRINTHINE FLUIDS 

SEE ALSO EYE, AQUEOUS HUMOR 

SEE ALSO NERVOUS SYSTEM CENTRAL, CEREBROSPINAL 

FLUID 
SEE ALSO URINE* 
POlHL-06835 17 0059 Cardiovascular disease - 

Metyrapone-induced hypertension in dog 
** POlHL-082 14-15 0047 Chemical and biological properties 

of lipids - High resolution liquid chromatography for the 

analysis of biological substances 
R01HL-I0942-09 Study of genetic hypertension in rats 
** POlHL-11678-11 0020 Cardiovascular dynamics and their 

control - Circulatory and pulmonary fluid dynamics during 

pulmonary edema 
POlHL-11678-11 0064 Cardiovascular dynamics and their 

control - Renal medulla -Control of renal hemodynamics, 

electrolyte excretion (dogs) 
** POlHL-11678-11 0065 Cardiovascular dynamics and their 

control - Body fluid volumes in the genesis of hypertension 

(dogs) 
POlHL-11678-11 0068 Cardiovascular dynamics and their 

control - Basic hemodynamics (rats, dogs) 
ROlHL-12990-09 Control of antidiuretic hormone secretion 

and metabolism (dogs, rats, rabbits) 
ROlHL-131 72-10 Post-trauma lung mechanics and fluid 

exchange (human, dogs, monkeys) 
ROIHL-13901-08 Ontogeny, ultrastructure, function in 

lymphatic system (birds, fish, mammals) 
ROlHL-16855-03 Cavitation in biological systems 

(microorganisms, animals) 
R01HL-19065-02 Molecular oxygen in biological fluids 
ROlHL-19678-01 Quantification of intrathoracic fluid by 

impedance (human, dogs) 
ROlHL-19825-02 Renin-volume interactions in coarctation 

hypertension (dogs) 
ROlHL-21498-02 Pathophysiology of edema (rats, cats) 
ROlHL-22026-01 Endogenous prostaglandins in asthma 
ROlHL-22233-01 Characterization of bio-materials by 

elastic property 
ROIHL-22506-01 Hemodynamics of the clinical 

hypertensions 



BOD 

BODY FLUIDS, EXTRACEUULAR SPACE 
(COMPARTMENT) 

Ml Also CONNfCtlVI TI5SUf, GROUND MlhMANCf 
ROIHI 02163 20 Kinetics ol wiler and elertrolytti In 

shock (dogs, rnh) 
" PUIMI II6/H 11 0015 Cardiovatcultr dynamici end Ihfir 

Lonliol lymph How rale and protein concentration (dogl) 
" POIHI 116/8 II 0039 Cardiovascular dynamics and their 

control Capillary and inlerilitial lluid dynamics ol Ihe 

intestine (cats) 
POIHL 116/8 II 0040 Cardiovascular dynamics and their 

control Control of plasma potassium concentration (dors) 
" POIHI II6/K n 005/ Cardiovascular dynamics and Iheir 

control Return of urine lo circulation using cystico caval 

shunt (dogs) 
POIHL 116/8 II 00/0 Cardiovascular dynamics and their 

control Interaction ol Ihe lour Starling forces (dogs) 
ROIHL 13841 16 Respiration during altitude 

acclimatization (goals, dogs, rats, rabbits) 
P50HL 14159 08 0008 Specialized center ol research in 

hypertension Renal function and sodium metabolism in 

hypertension (rats, human, rabbits) 
P50HL 14214 07 0025 Newborn lung center for hyaline 

membrane disease Pulmonary vascular permeability and 

lung water Hyaline membrane disease (sheep) 
POIHL 14388 0/ 0154 Regulation of the circulation in 

pathological states Energetics of smooth muscle 

contraction (rats) 
POIHL 15835-06 0023 Study of muscles related to heart 

disease Cellular basis ol the Frank Starling curve (Irogs, 

rats) 
ROIHL 16658 05 Intrarenal regulation of sodium 

reabsorption 
ROIHL 17366-05 Mechanisms in the production of renal 

hypertension (rabbits, dogs) 
P50HL 18318-03 0004 Pathogenesis and complications of 

hypertension Steroid and renin profiles in hypertension 

(rats, human) 
P50HL-18318-03 0007 Pathogenesis and complications of 

hypertension Humoral factors and renal function in 

experimental hypertension (rats) 
P50HL-18318-03 0010 Pathogenesis and complications of 

hypertension - Hemodynamics in mineralocorticoid and low 

renin hypertension (human) 
POlHL-18575-03 0002 Mechanisms of vascular changes 

in hypertension - Endocrines. electrolytes, and 

hemodynamics in hypertension (pigs) 
ROlHL-20153-02 Intracellular pH and myocardial 

electropharmacology (dogs, guinea pigs) 
ROlHL-2074901 

(sheep) 
ROlHL-20878 02 



Developing heart -Biophysical aspects 
Cellular aspects of lung injury (rats. 
Dynamics of interstitial space in whole 



*£icludes routine methodokigy OR covers only general projects wtilch preclude indexing 
"Oriented significantly to above subject 



at the specific level. 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



rabbits) 
** R01HL-2I282-01 

animals (rats) 
** ROlHL-22261-01 Compliance of fluid spaces in advancing 

hypertension (rats) 
ROlHL-22281-01 Microprobe analysis and metabolite 

levels of ischemic mycardium (dogs) 
ROlHL-22594-01 Reflex control of the circulation in heart 

failure (dogs) 
POIHL 22619-01 0008 Cellular mechanisms of heart 

failure - Molecular mechanisms and differential contractile 

responsiveness in VSM (dogs) 
ROlHL-22911-01 Mechanism of clearance of lung edema 

fluid (dogs) 
ROlHL-23201-01 Mechanisms of hypertension (human, 

rats) 

BODY FLUIDS, EXUDATES AND TRANSUDATES 

SEE ALSO BODY FLUID BALANCE, EDEMA 
POlHL-10342-13 0006 The integrated function of 

respiration and circulation - Lung inflation effects on 

pulmonary vasculature and interstitial space (dogs) 
ROlHL-13596-07 Clearance of plasma proteins from 

alveoli 
POlHL-15832-06 0010 Chemical-structural predispositions 

to lung injury - Kinin generating systems in pulmonary 

disease (human, animals) 

BODY FLUIDS, MILK 

SEE ALSO REPRODUCTIVE SYSTEM FEMALE, MAMMARY 
GLANDS 
ROlHL-18712-03 Iron deficiency-hyperlipidemia in 
development (rats) 

BODY FLUIDS, MUCUS 

SEE ALSO PROTEOGLYCANS, MUCIN 
SEE ALSO RESPIRATORY SYSTEM, BRONCHIAL MUCUS 
ROlHL-14271-07 Physico-chemical properties of tracheal 

mucus (dogs, frogs) 
ROIHL-16730-03 Physiology of mucociliary transport (rats, 
frogs, rabbits) 
** P50HL-19157-02 0003 Studies in cystic fibrosis and 

bronchiolitis - Nasal mucosal function in patients with 
cystic fibrosis 
** P50HL-19157-02 0004 Studies in cystic fibrosis and 

bronchiolitis - Macromolecular regulators of mucus 
secretion-Invertebrate model 

BODY FLUIDS, SPUTUM 

SEE ALSO ORAL-PHARYNGEAL. SALIVA 

SEE ALSO RESPIRATORY SYSTEM. BRONCHIAL MUCUS 

(contd) 



BOD 

R01HLU844-06 Mucous glycoprotein in human tespiratorv 

epithelium (also wheat) 
P50HL-19160-02 0002 Mucus abnormality in cystic 
fibrosis - Ultrastructure, cytochemistry of pulmonary 
secretion (human, rat) 
BODY FLUIDS, TISSUE SPACES 

POlHL-06285-18 0212 Cardiovascular-respiratory 
physiology and biochemistry - Membrane structure and 
function-Gap junction (bovine) 
BODY FLUIDS, VISCOSITY-VISCOELASTICITY 

SEE ALSO BLOOD VISCOSITY-VISCOELASTICITY 
** R01HL-U271-07 Physico-chemical properties of tracheal 

mucus (dogs, frogs) 
*• ROlHL-15155-05 Rheology of pulmonary secretions (dogs) 
ROlHL-16730-03 Physiology of mucociliary transport (rats, 

frogs, rabbits) 
ROlHL-20989-01 Pathophysiology of bronchial asthma 
(sheep, dogs) 
BODY FLUID BALANCE, ACID-BASE 

SEE ALSO ACIDS-BASES, HYDROGEN-ION CONCENTRATION 
SEE ALSO RESPIRATORY GAS LEVELS, BOHR EFFECT 
SEE ALSO URINE ACIDITY 
♦* R01HL-00340 29 Electrolyte disturbance in cardio-renal 

disease (human, dogs, rats) 
** R01HL-00759-29 Regulation of electrolyte and acid base 
equilibrium (dogs) 
ROlHL-02363-20 Kinetics of water and electrolytes in 

shock (dogs, rats) 
POlHL-06285-18 0182 Cardiovascular-respiratory 
physiology and biochemistry - Structure and function of 
vascular chemoreceptors (cats, rats) 
POlHL-06285-18 0188 Cardiovascular-respiratory 
physiology and biochemistry - Physiology and pharmacology 
in regulation of airways-hyperirritability (animals) 
** POlHL-06285-18 0197 Cardiovascular-respiratory 
physiology and biochemistry - Microperfusion and 
micropuncture of renal tubules (hamsters, desert rats) 
POlHL-06285-18 0198 Cardiovascular-respiratory 
physiology and biochemistry - Renal tubular secretion of 
hydrogen ion (animals) 
P01HL-08805-15 0006 Regulation of ventilation and 

pulmonary circulation - Adaptation of lungfish-Estivation 
P01HL-08899-14 0031 Tolerance to respiratory gases in 
health and disease - Studies in exercise (human, dogs) 
** P01HL-08899-14 0033 Tolerance to respiratory gases in 
health and disease - Acid-base related influences of 
hypoxia (human) 
•* P01HL-08899-U 0034 Tolerance to respiratory gases in 
health and disease - Hyperoxygenation and respiratory 
response to acid-base stimuli (human, dog) 
POlHL-08899-14 0041 Tolerance to respiratory gases in 
health and disease - Blood gas transport and brain 
circulatory control (human) 
** POlHL-10342-13 0023 The integrated function of 

respiration and circulation - Carbon dioxide transport and 
CSF acid base balance (hogs, pigs) 
ROlHL-12677-10 Surgical physiologic studies of isolated 

kidneys (dogs, rats) 
R01HL-12777-09 Mechanisms in cardiac performance 

(dogs, human) 
ROlHL-13257-09 Inhalation anesthesia on myocardial 

metabolism (dogs, swine, human) 
P50HL-14218-07 0004 Pulmonary SCOR-Newborn lung 

center - Metabolism of infants with respiratory distress 
syndrome (human) 
*• P50HL-14218-07 0018 Pulmonary SCOR-Newborn lung 
center - Whole body buttering in acute hypercapnia (dogs) 
POlHL-144 14-07 0010 Environmental influences on 

cardiorespiratory and cellular functions - Pressure effects 
on cardiac electrical phenomena (animals) 
** POlHL-14414-07 0014 Environmental influences on 

cardiorespiratory and cellular functions - Temperature and 
acid-base status In tissues, cells, and subcellular system 
ROlHL-14720-08 Factors governing the renal excretion of 
acid (humans, rats) 
** P60HL-15157-07 0012 Comprehensive center for sickle 
cell disease - Sickling and intracellular pH (human) 
ROIHL 15469-06 Human ventilatory adaptation (also, 
dogs, rats) 
*• ROIHL- 158 10-06 Electrolyte physiology and respiratory 
acid-base (dogs) 
ROlHL-16292-05 0002 Surgeiy and non-obstructive 
coronary insufficiency - Effects of hypothermia during 
cardiopulmonary bypass (dogs) 
ROlHL-16463-05 Localization of airways obstruction and 

responses 
ROIHL 16916-04 0002 The role of albumins in lung water 
accumulation ■ Lung water balance-Forces, models and 
albumin concentrations (rabbits, dogs) 
ROlHL-17352-03 Physiological regulation during chronic 

hyperthermia (sheep) 
ROlHL-17629-03 Developmental aspects of cardiovascular 

function (human, cats, rabbits) 
POIHL-17731-04 0010 Physiological basis of pulmonary 

disease - Gas exchange kinetics (dogs) 
ROIHL- 17963-04 Human erythrocyte carbonic anhydrase 
ROlHL-18082-03 Erythrocyte phosphates and vertebrate 
gas transport (amphibians, reptiles) 
•* ROlHl-18351-03 Brain metabolism, acid-base balance, 
and respiration 



70 

ROlHL-18371-03 Pulmonary hypertension and ventilation 

pathophysiology (dogs) 
ROlHL-18489-03 Hemodynamic interactions of vasoactive 

chemicals (rats) 
ROlHL-18798-04 0001 Nervous and ionic factors in 
sudden cardiac death - Potassium loss during myocardial 
ischemia (rabbits) 
P50HL-191 90-02 0006 Pulmonary SCOR -Pathophysiology, 
management of IRDS - Asphyxia-Respiratory control (dogs) 
P50HL-191 90-02 0007 Pulmonary SCOR -Pathophysiology, 
management of IRDS - Asphyxia-Cerebral metabolism (dog, 
rat) 
POlHL-19737-02 0005 Cellular and molecular aspects ot 

respiratory physiology - Interaction of respiratory exchanges 
and blood gas parameters (human, animals) 
** ROlHL-201 53-02 Intracellular pH and myocardial 
electropharmacology (dogs, guinea pigs) 
ROlHL-20262-02 Cardiac glycosides and the mechanism 

of the sodium-potassium pump 
ROlHL-20568-03 Respiration during prolonged hypercapnia 

(rats) 
ROlHL-20635-03 Factors in lung development (rat and 

chick embryo) 
ROlHL-22258-01 New aspects of pharmacology related to 

carbonic anhydrase 
R23HL-22575-01 Factors modifying cardiac digoxin effects 
and content (dogs, cats) 
** ROlHL-22650-01 Regulatory mechanisms of erythropoietin 

production (human, rats, mice) 
BODY FLUID BALANCE, ACID-BASE, ACIDOSIS 
SEE ALSO CARBOHYDRATES METABOLISM DISORDERS. 

DIABHIC ACIDOSIS 
SEE ALSO KETONE BODIES 
SEE ALSO METABOLIC DISORDERS (INBORN), RENAL 

TUBULAR ACIDOSIS 
SEE ALSO RESPIRATORY DISORDERS. ACIDOSIS, 
RESPIRATORY 
ROlHL-02888-22 Interrelationships of circulation and 

respiration (opossum, cats) 
POlHL-06285-18 0125 Cardiovascular-respiratory 
physiology and biochemistry - Myocardial function in the 
fetal and neonatal lamb 
POlHL-06285-18 0188 Cardiovascular-respiratory 
physiology and biochemistry - Physiology and pharmacology 
in regulation of airways-hyperirritability (animals) 
POlHL-06296-18 0005 Cardiovascular and pulmonary 
adaptation to stress ■ Regulation of ventricular 
performance (animals) 
** ROlHL-08659-14 Myocardial performance and metabolism 
In the newborn (sheep) 
POlHL-08899-14 0035 Tolerance to respiratory gases in 
health and disease - Simulation of the increased 
metabolism of exercise (dogs) 
POlHL-10436-13 0005 A multidisciplinary study of 
congenital heart disease - Pulmonary physiology In 
congenital heart disease (human) 
ROlHL-11046-12 Renin, angiotensin, steroids, ions and 

blood pressure (human, sheep, rabbits) 
POlHL-11351-12 0015 Cellular and molecular 
mechanisms of myocardial function - Effects of hypoxia 
and ischemia on ion exchange and heart function (rabbits) 
ROlHL-1 1907-08 Mechanisms of physiological responses 

to exercise (human, dogs) 
POlHL-14414-07 0014 Environmental influences on 

cardiorespiratory and cellular functions - Temperature and 
acid-base status in tissues, cells, and subcellular system 
ROlHL-14646-05 Pathophysiology of myocardial ischemia 

(dogs, rats) 
POlHL-14985-07 0003 Adaptation to hypoxia - Hypoxia 
and oxygen transport (human, dogs) 
•* POlHL-14985-07 0005 Adaptation to hypoxia - Control 
mechanisms in the pulmonary microcirculation (animals) 
ROlHL-15522-06 Influence of mannitol on ischemia 

cardiac muscle (dogs, cats, rats) 
POlHL-15832-06 0007 Chemical-structural predispositions 
to lung injury - Inactivation of vasoactive agents by the 
lung (human, rats, cats, dogs) 
ROlHL-16022-05 Determinants of the ventilatory response 
to hypoxia (goats, cats) 
** P50HL-17669-04 0006 Ischemic heart disease center 
(SCOR) Studies of hypoxic, acidotic and ischemic cardiac 
muscle (dogs) 
P50HL-17669-04 0007 Ischemic heart disease center 
(SCOR) - Relationship between myocardial depression and 
compliance (dogs, cats) 
P50HL-17569-04 0011 Ischemic heart disease center 
(SCOR) - Lysosomal function and lysosomal enzymes in 
normal and ischemic heart (rabbit) 
P50HL-17669-04 0022 Ischemic heart disease center 
(SCOR) - Pathological studies of human and experimental 
ischemic heart disease 
P50HL-17682-04 0024 Study of ischemic heart disease ■ 
Phosphorylation of cardiac contractile proteins during 
ischemia (rat, guinea pig) 
ROIHL 18647-03 Ischemic myocardial injury in cultured 

heart cells (rats) 
ROlHL-194 10-03 Dynamic interrelations underlying 
exercise hyperpnea (human) 
** R23HL-19601-01 Cardiac response to chronic metabolic 
acidosis (rats) 
ROlHL-201 53-02 Intracellular pH and myocardial 
electropharmacology (dogs, guinea pigs) 



BOD 

ROlHL-21187-01 Potassium, norepinephrine, and coronary 

arterial tone (dogs) 
R23HL-21262-02 Sodium-calcium interactions in 

mammalian myocardium (rabbits, cats) 
R23HL-22575-01 Factors modifying cardiac digoxin effects 

and content (dogs, cats) 
ROlHL-22650-01 Regulatory mechanisms of erythropoietin 

production (human, rats, mice) 
ROlHL-23128-01 Cardiac contractility-Ischemia and 

hypoxia (rabbits, rats) 
ROlHL-23166-01 Pathology of mitochondria in ischemic 
myocardium (rats, cattle) 
BODY FLUID BALANCE, ACID-BASE, ALKALOSIS 
POlHL-08899-14 0030 Tolerance to respiratory gases in 
health and disease - Dynamic characteristics of respiratory 
control components (human, cats) 
P50HL-14218-07 0018 Pulmonary SCOR-Newborn lung 

center - Whole body buffering in acute hypercapnia (dogs) 
ROlHL-14693-07 Survival value of physiological responses 

to hypoxia (dogs) 
POlHL-14985-07 0002 Adaptation to hypoxia - Oxygen 

transport in man at high altitude 
POlHL-14985-07 0003 Adaptation to hypoxia - Hypoxia 

and oxygen transport (human, dogs) 
POlHL-14985-07 0009 Adaptation to hypoxia - Influence 
of chemosensitivity on control of breathing during sleep 
(human, dogs) 
** ROlHL-15810-06 Electrolyte physiology and respiratory 
acid-base (dogs) 
POlHL-15832-06 0007 Chemical-structural predispositions 
to lung injury - Inactivation of vasoactive agents by the 
lung (human, rats, cats, dogs) 
ROlHL-16022-05 Determinants of the ventilatory response 

to hypoxia (goats, cats) 
ROlHL-16658-05 Intrarenal regulation of sodium 

reabsorption 
ROlHL-18328-03 Hemoglobin function and tissue 

oxygenation (human, dogs) 
ROlHL-18730-03 Role of mineralocorticoids in low renin 

hypertension (human, rats) 
R23HL-19601-01 Cardiac response to chronic metabolic 

acidosis (rats) 
ROlHL-20153-02 Intracellular pH and myocardial 

electropharmacology (dogs, guinea pigs) 
ROlHL-20196-02 Regulation of coronary arterial smooth 

muscle 
ROlHL-22390-01 Effect of chloride on renin (rats, dogs) 
R23HL-22575-01 Factors modifying cardiac digoxin effects 
and content (dogs, cats) 
BODY FLUID BALANCE, ACID-BASE, 
ANTIACIDOSIS DRUGS 
P50HL-19 185-02 0007 Pulmonary SCOR-Neonatal 
respiratory distress syndromes - Sodium bicarbonate and 
albumin in resuscitation of preterm infants (human) 

BODY FLUID BALANCE, BODY WATER 

SEE ALSO BIOLOGICAL TRANSPORT, FLUID EXCHANGE AND 

TRANSPORT 
SEE ALSO CELL FLUIDS, CELL WATER 
SEE ALSO NUTRIENT INTAKE ACTIVITY. DRINKING BEHAVIOR 

(WATER) 
SEE ALSO NUTRIENT INTAKE ACTIVITY, THIRST 
R01HL-00340-29 Electrolyte disturbance in cardio-renal 

disease (human, dogs, rats) 
ROlHL-02363-20 Kinetics of water and electrolytes in 
shock (dogs, rats) 
** POlHL-06312-17 0047 Surgical cardiology - Myocardial 

extravascular water (dogs) 
** POlHL-1 1578-11 0027 Cardiovascular dynamics and their 
control - Vasopressin and thirst in control of body fluid 
volumes and osmolality (dogs) 
POlHL-11678-11 0035 Cardiovascular dynamics and their 
control - Lymph flow rate and protein concentration (dogs) 
** POlHL-11678-11 0046 Cardiovascular dynamics and their 
control - Regulation of aldosterone secretion and related 
factors (dogs) 
POlHL-11678-11 0058 Cardiovascular dynamics and their 
control - Overall control of the circulation-Computer 
analysis 
ROlHL-12690-09 Systemic and local vascular adjustment 

in shock (monkeys, cats) 
P50HL-14159-08 0008 Specialized center of research in 
hypertension - Renal function and sodium metabolism in 
hypertension (rats, human, rabbits) 
P50HL-14214-07 0025 Newborn lung center for hyaline 
membrane disease - Pulmonary vascular permeability and 
lung water-Hyaline membrane disease (sheep) 
P50HL-14218-07 0017 Pulmonary SCOR-Newborn lung 
center - Transvascular fluid exchange, vasoactive mediators 
in RDS (sheep, cat) 
P50HL-14218-07 0018 Pulmonary SCOR-Newborn lung 

center - Whole body buffering in acute hypercapnia (dogs) 
POlHL-14388-07 0192 Regulation of the circulation in 

pathological states - Renal tubular secretion of magnesium 
(rats) 
POIHL 14414-07 0004 Environmental influences on 

cardiorespiratory and cellular functions - Role of diffusion 
in gas exchange (chicken egg) 
ROlHL-15655-05 Blood flow and gas exchange in placenta 
and lungs (sheep) rabbits) 

(contd) 



*Exdudes routine methodotogy OR covers only general projects which preclude 
"Ohented significantly to above subject. 



Indexing at the specific level. 



M Grant has subprojects describing specific research aspects. 
See Appendix for Investigator's name and grant number 



too 



ROIHL 16916 04 000? Tht roll ol llbumlni In lung wit*r 

<ccumul<lion lung watti hilince Fotc«, modals and 

albumin concantrations (labbits. do|}) 
ROIHl 16916 04 0011 Tb« role of albumins in lung nalur 

accumulation Wbola body disltibution and airhanie ol 

albumin (rabbits, human, monkeyj) 
ROIHI i;b;i 03 Study ot membrant parmeability by NMR 

ralaiation (human) 
POIHl 18575 03 0002 Machanisms ol vasculii changes 

in hyp«rtansion Endocrints. tieclrolytes. and 

hemodynamics m hypertension (pigs) 
POINL \«bli 03 000b Mechanisms ot vascular changes 

in hypertension Renin synthesis in normotensive and 

hypertensive pigs (also rats, dogs) 
PSOHL 191SS 02 0001 Pathophysiology ot pulmonary 

edema Pulmonary edema study unit (human, dog) 
ROIHL 20861 01 Cardio-raspiritoiy renal stress reactions 

(dogs) 
ROIHL 2180001 

excretion 
ROIHL 2261701 

(sheep) 
ROIHL 2285901 



Angiotensin effects on water intake and 
Angiotensin, hypertension and the CNS 
Effect of carbon mononide on the 



developing heart (rats) 

BODY FLUID BALANCE, BODY WATER, 
DEHYDRATION 

SEE ALSO BODY FLUID BALANCE. BODY WATER LOSS 
POIHL 11678 11 0040 Cardiovascular dynamics and their 

control Control ot plasma potassium concentration (dogs) 
P60HL 15157 07 0018 Comprehensive center lor sickle 

cell disease Red blood cell membrane physiology in sickle 

cell anemia (human) 
ROIHL 1920903 Role of ADH in experimental renal 

hypertension (dogs, rats) 
ROIHL 2205101 Role of angiotensin II in vasopressin 

release (human) 

BODY FLUID BALANCE, BODY WATER EXCESS 

SEE ALSO BODY FLUID BALANCE. EDEMA 
ROlHL-20110'02 Microwave methods of lung water 
measurement (dogs, phantom models) 

BODY FLUID BALANCE, BODY WATER LOSS 

SEE ALSO BODY FLUID BAUNCE. BODY WATER. 

DEHYDRATION 
SEE ALSO SKIN SECRETIONS. SWEAT 
SEE ALSO URINE* 
ROlHL-1935203 Respiratory heat and water loss in 

neonates 
ROlHL-21126-02 Exercise-induced bronchospasm in 
children 

BODY FLUID BALANCE, EDEMA 

SEE ALSO BODY FLUIDS, EXUDATES AND TRANSUDATES 

SEE ALSO BRAIN DISORDERS. BRAIN EDEMA 

SEE ALSO CAROIOVASCUUR DISORDERS, HYPERTENSION 

(SYSTEMIC) 
SEE ALSO CARDIOVASCULAR DISORDERS, HYPERTENSION 

(SYSTEMIC). ANGIOTENSIN-RENIN-ALDOSTERONE- 
ASSOCIATED 
SEE ALSO EYE DISORDERS. PAPILLEDEMA 
SEE ALSO METABOLIC DISORDERS INBORN, ANGIONEUROTIC 

EDEMA (HEREDITARY) 
SEE ALSO RESPIRATORY DISORDERS, PULfi/IONARY EDEMA 
ROlHL-02493-22 Kidney function in experimental heart 

failure (dogs, rats) 
POlHL-06285-18 0143 Cardiovascular-respiratory 
physiology and biochemistry - Myocardial ischemia (human, 
dogs, lambs) 
** POlHL-06664-17 0010 Cardiopulmonary function in 
remediable vascular disease - Ischemia and acute renal 
failure (rats) 
** POlHL-1 1310-12 0053 Mechanisms of cardiovascular 
disease Ventricular pressure-volume after cardipulmonary 
bypass (dogs) 
POlHL-11310-12 0063 Mechanisms of cardiovascular 
disease - Myocardial function, metabolism and cellular 
integrity after heart surgery (dogs) 
P01HL-1I678-11 0035 Cardiovascular dynamics and their 

control - Lymph flow rate and protein concentration (dogs) 
POlHL-1 1678-11 0068 Cardiovascular dynamics and their 
control - Basic hemodynamics (rats, dogs) 
** ROlHL-12421-10 Pathophysiology of circulatory shock 
(dogs, baboons) 
R01HL12493-10 Bioengineering analysis of microvascular 

function (cats, rabbits) 
ROlHL-12974-10 Tracer kinetics, flows and masses in 
body organs (human, dogs) 
** ROlHL-13323-08 Intrarenal pressure and renal function 

(human, dogs) 
** POlHL-14388-07 0232 Regulation of the circulation in 
pathological states - Idiopathic cyclic edema 
ROlHL-15522-06 Influence of mannitol on ischemia 

cardiac muscle (dogs, cats, rats) 
R01HL-16658-05 Intrarenal regulation of sodium 
reabsorption 
** ROIHL- 17458-04 Renal control of sodium excretion (rats) 
P50HL- 17665-04 0021 Study of ischemic heart disease - 
Identification, prevention-Myocardial ischemia in 
cardiopulmonary bypass (dog) 



71 

PbOHt 17667 04 002? Study ol ischemic heart diiaau 

Preventing myocardial injury in surgery using 

cardiopulmonary bypass (human, rat) 
PbOHl 17669 04 0006 Ischamic heart dliaau center 

(SCOR) Studies ol hypoxic, acidotic and iichimic cardiac 

muscle (dogs) 
P50HL 1/669 04 0022 Ischemic heart disease center 

(SCOR) Pathological studies ol human and experimental 

ischemic heart disease 
ROIHL 18024 03 Regional myocardial flow and function 

relationships (dogs) 
POIHL 18646 03 0008 Studies basic to heart 

transplantation Immunophysiology and early detection ol 

reiection (dogs) 
POIHL 1864603 0009 Studies basic to heart 

transplantation Pathologic aspects ol cardiac allograft 

reiection (sheep, dogs) 
ROIHL 18862 02 Thirst and its contribution to edema 

(dogs) 
ROIHL 1967801 Quantification of intrathoracic fluid by 

impedance (human, dogs) 
ROIHL 20080 02 Surgically induced myocardial edema 

(dogs) 
ROIHL 20143 02 Hypothermic circulatory arrest Cerebral 

vascular change (dogs) 
ROIHL 20201 01 Hypertension and vascular steroid 

receptors (rats) 
ROIHL 20283 02 Maintenance of cellular integrity in 

ischemic hearts (cats) 
ROIHL 20648 01 Physical factors and coronary flow (dogs) 
R23HL 21066 02 Angiotensin and prostaglandin control of 

aldosterone (rats) 

Pathophysiology of edema (rats, cats) 
Natural history of the postphlebitic 



Role of angiotensin II in vasopressin 



•* R01HL21498-02 
ROlHL-21572-01 

syndrome 
ROIHL 22051 01 

release (human) 
•* POlHL-22602-01 0002 Pathophysiology of the 

endothelium Molecular charge and endothelial 

permeability (rats, mice) 
ROlHL-2360201 Physiology of renin, aldosterone and 

prostaglandin (human, rats, dogs) 

BODY FLUID BALANCE, IONIC 

SEE ALSO ADRENAL GLANDS DISORDERS, 

HYPERALDOSTERONISM 
SEE ALSO BIOLOGICAL TRANSPORT, ACTIVE TRANSPORT, ION 

PUMPS 
SEE ALSO BIOLOGICAL TRANSPORT, ION EXCHANGE AND 

TRANSPORT 
SEE ALSO BLOOD TREATMENT. HEMODIALYSIS 
SEE ALSO BODY FLUID BALANCE. ACID-BASE 
SEE ALSO CALCIUM (MINERAL) BALANCE (METABOLISM) 
SEE ALSO CAROIOVASCUUR DISORDERS. HYPERTENSION 

(SYSTEMIC). ANGIOTENSIN-RENIN-ALDOSTERONE- 
ASSOCIATED 
SEE ALSO KIDNEY FUNCTION 
SEE ALSO NUTRIENT INTAKE ACTIVITY, SALT INTAKE 
ROlHL-02228-24 Respiration, circulation, and heat 

regulation in exercise (bird, mammals) 
ROlHL-02334-23 Micropuncture study of kidney function 
(rats, animals) 
** R01HL02363-20 Kinetics of water and electrolytes in 

shock (dogs, rats) 
** ROlHL-02493-22 Kidney function in experimental heart 

failure (dogs, rats) 
** ROlHL-03303-21 Factors regulating electrolyte excretion by 
the kidney (human, dogs) 
POlHL-06285-18 0145 Cardiovascular-respiratory 

physiology and biochemistry • Pulmonary, pleural and 
systemic microcirculation (animals) 
" P01HL06285-18 0197 Cardiovascular-respiratory 

physiology and biochemistry - Microperfusion and 
micropuncture of renal tubules (hamsters, desert rats) 
POlHL-06285-18 0200 Cardiovascular-respiratory 
physiology and biochemistry - Medullary counter-current 
system (animals) 
" POlHL-063 12-17 0051 Surgical cardiology - Diuretic 
therapy on myocardial electrolyte composition and water 
content (human) 
POlHL-06664-17 0037 Cardiopulmonary function in 

remediable vascular disease - Salt and water balance of 
cells and tissues (rabbits) 
POlHL-06835-17 0048 Cardiovascular disease • 
Aldosterone producing adenoma prediction of curability 
(human) 
** POlHL-0868215 0026 Regulation of the cardiovascular 

system • Hypertension-High renin vs low renin (dog) 
** POlHL-08682-15 0027 Regulation of the cardiovascular 

system - Cardiac mechanoreceptors -Reflex regulation of 
renal function (dogs) 
** ROlHL-09906-13 0019 Membrane transport processes in 
red blood cells - Hemoglobin change and membrane 
potentials in red blood cells at varying volumes 
ROlHL-106 12-13 0018 Humoral factors in heart failure 
and hypertension - The pathogenesis of experimental renal 
hypertension (dogs, rabbits, rats) 
ROlHL-109 14-10 Renal sodium transport in experimental 
aldosteronism (dogs) 
** ROlHL-1 1046-12 Renin, angiotensin, steroids, ions and 

blood pressure (human, sheep, rabbits) 
M P01HL11678-11 Cardiovascular dynamics and their 
control 



BOD 

POIHl 116/8 II 00?/ Cardiovaiculai dynamict and intii 

control Vatoprtiiin and Ihirtt in control ol body lluid 

volumtt and otmolality (do|t| 
POIHl 116/8 II 0031 Cardiovaiculai dynamic! and than 

control Hyparlantion caused by ilimulalion ol lanal 

sympathetic nerval Idogi) 
POIHl 116/8 II 0040 Cardiovascular dynamics and Ihair 

control Control of plasma potaiiium concentration Idogi) 
POIHl 116/8 II 0060 Cardiovascular dynamics and thair 

control Salt and water balance in one kidney Goldblalt 

hypertension (rat) 
POIHl 1215/ II 0058 Functions and mechaniimi ol call 

membrane ion transport Ionic and osmotic regulation in 

loadfish A euryhaline aglomerular teleosl 
ROIHL 1282/08 Regulation of sodium excretion (dogs, 

rats) 
ROIHl 1323/ 09 Erythrocytes during early development 

(human, animals) 
ROIHl 1342/ 09 Neural control of blood volume (monkeys. 

dogs) 
ROIHL 14306 07 Quantification of arterial pressure control 

(dogs) 

Regulation of the circulation In 
Renal tubular secretion of magnesium 



Regulation of the circulation in 
Kallikrein kinin system in hypertension 

Regulation of the circulation in 
Kallikrein kinin system in hypertension 



POIHL 1438807 0192 

pathological states 

(rats) 
POIHL 1438807 0223 

pathological states 

(rats) 
POIHL 1438807 0224 

pathological states 

(human) 
ROIHL 14720 08 Factors governing the renal excretion of 

acid (humans, rats) 
ROIHL 1546906 Human ventilatory adaptation (also, 

dogs, rats) 
ROIHL' 158 10-06 Electrolyte physiology and respiratory 

acid-base (dogs) 
ROIHL 16657 06 Innervation of coronary arteries and heart 

(rats) 
PO1HL-16910-05 0001 Regulation of the peripheral 

circulation - Quantitative studies of microcirculatory control 

(bats) 
ROlHL-17407-05 Peripheral circulation and fluid balance 

(fish, mammals, human) 



Cardiovascular and renal functions of 

Studies in lung preservation (dogs) 
Capillary transport of large molecules 



ROlHL-17847-04 

marmots 
ROlHL-17944-03 
ROlHL-1801004 

(dogs, sheep) 
ROIHL 18288-04 Intraoperative protection of the 

myocardium (dogs, rats) 
P50HL-18318-03 0007 Pathogenesis and complications of 

hypertension - Humoral factors and renal function in 

experimental hypertension (rats) 
P50HL-18323 04 0011 SCOR hypertension center - 

Endocrine profiling on a selected normal population 

(human) 
P50HL-18323-04 0037 SCOR hypertension center - 

Adrenocortical factors in childhood hypertension 
P50HL-18323-04 0045 SCOR hypertension center ■ 

Laboratory programs -Prorenin (human) 
ROlHL-18426-04 Regulation of renal hemodynamics (dogs) 
POlHL-18575-03 0002 Mechanisms of vascular changes 

in hypertension - Endocrines. electrolytes, and 

hemodynamics in hypertension (pigs) 
ROlHL-18579-03 Vasoactive hormones and blood pressure 

regulation (dogs, rats, rabbits) 
ROlHL-18798-04 Nervous and ionic factors In sudden 

cardiac death 

Nervous and ionic factors in 
Potassium loss during myocardial 



ROlHL-18798-04 0001 
sudden cardiac death 
ischemia (rabbits) 

ROlHL-18798-04 0002 
sudden cardiac death 



•Excludes routine methodokigy OR covers only general projects which preclude Indexing 
**0nented significanthi to above subject. 



at the specific level. 



M Grant has subprojects descnbing specific research aspects. 
See Appendix for investigator's name and grant number. 



Nervous and ionic factors in 
Electron microprobe, ultrastructure 

analysis of ischemic myocardium (dog, rabbit) 
R01HL18845-04 Regulation of renal circulation and salt 

excretion (rats, dogs) 
ROlHL-1886202 Thirst and its contribution to edema 

(dogs) 
ROlHL-19320-03 Angiotensin neuropharmacology - 

Relationship to sodium 
R23HL-19601-01 Cardiac response to chronic metabolic 

acidosis (rats) 
ROlHL-20176-02 Biochemistry and genetics of salt 

hypertension (rats) 
ROlHL-20190-02 

(dogs) 
ROlHL-20201-01 

receptors (rats) 
ROlHL-2086101 

(dogs) 
R23HL-21066-02 

aldosterone (rats) 
ROlHL-21092-02 Factors other than renin in renal 

hypertension (rats) 
ROlHL-21094-01 Arterial baroreceptors and renal function 

(dogs) 
ROlHL-21272-02 Sodium homeostasis and renal 

prostaglandins (dogs) 
R01HL-21274-0I Prorenin-Physiological and biochemical 

analysis (human) 

(contd) 



Pathogenesis of cardiac hypertrophy 
Hypertension and vascular steroid 
Cardiorespiratory-renal stress reactions 
Angiotensin and prostaglandin control of 



BOD 

** ROlHL-21525-02 Effect of cations, anions and water upon 

blood vessels (dogs, rats) 
ROlHL-21673-01 Pathophysiology of venous changes in 

hypertension (rats, rabbits, human, dogs) 
ROlHL-21800-01 Angiotensin effects on water intake and 

excretion 
ROlHL-22069-02 Experimental renal arterial hypertension 

(dogs) 
R23HL-22245-02 Functional characteristics of atrial 

receptors (rats) 
ROlHL-22411-01 Neuroendocrine involvement in 

hypertension (rats) 
ROlHL-22482-01 Circulatory hemodynamics and sodium 

excretion (dogs) 
R23HL-22575-01 Factors modifying cardiac digoxin effects 

and content (dogs, cats) 
ROlHL-23166-01 Pathology of mitochondria in ischemic 

myocardium (rats, cattle) 
** ROlHL-23600-01 Ions, water, and hypertension (human, 

dogs, rats) 
ROlHL-2360301 Morphogenesis of hypertensive vascular 

disease (rats) 

BODY FLUID BALANCE, IONIC, HYPERKALEMIA 

P01HL10342-13 0024 The integrated function of 

respiration and circulation - Cytochrome P450 and 

physiological response to hypoxia (rats) 
R01HL18796-04 Experimental cardiac arrhythmias (dogs) 
ROlHL-1903003 Tissue protection during circulatory 

interruption (dogs) 
** ROlHL-21786-01 Long-term effects of myocardial 

protection (dogs, rats) 
ROlHL-22123-02 The role of the red cell in diabetic 

atherosclerosis (human) 

BODY FLUID BALANCE, IONIC, HYPOKALEMIA 

SEE ALSO CARDIOVASCULAR DISORDERS, HYPERTENSION 

(SYSTEMIC), ANGIOTENSIN-RENIN-ALDOSTERONE- 
ASSOCIATED 
SEE ALSO METABOLIC DISORDERS INBORN, BARTTER'S 

SYNDROME 
R01HL-00340-29 Electrolyte disturbance in cardio-rena! 

disease (human, dogs, rats) 
ROlHL-00759-29 Regulation of electrolyte and acid base 
equilibrium (dogs) 
" R01HL-02986-21 Zonal renal change with potassium 
deficiency (rats, human) 
ROlHL-03303-21 Factors regulating electrolyte excretion by 

the kidney (human, dogs) 
POlHL-06835-17 0059 Cardiovascular disease ■ 

Metyrapone-induced hypertension in dog 
ROlHL-1 1046-12 Renm, angiotensin, steroids, ions and 
blood pressure (human, sheep, rabbits) 
•* R01HL-12792-09 Local control of the microcirculation 

(hamsters, rats) 
** ROlHL-12997-07 Myocardial defects induced by potassium 
depletion (human, rats, cats) 
ROlHL-16918-05 Role of steroids in hypertension (human) 
ROlHL-1873003 Role of mineralocorticoids in low renin 

hypertension (human, rats) 
ROlHL-19933-02 Membrane and red cell dysfunction in 
hemolytic anemia (human) 
** ROlHL-21525-02 Effect of cations, anions and water upon 
blood vessels (dogs, rats) 
RClHL-22390-01 Effect of chloride on renin (rats, dogs) 
ROlHL-23602-01 Physiology of renin, aldosterone and 
prostaglandin (human, rats, dogs) 

BODY FLUID BALANCE, IONIC, HYPONATREMIA 

RGlHL-00759-29 Regulation of electrolyte and acid base 

equilibrium (dogs) 
POlHL-06835-17 0047 Cardiovascular disease - 

Spironolactone in primary aldosteroidism (human) 
P01HL06835-17 0049 Cardiovascular disease - Selective 

hypoaldosteronism (human) 
POlHL-06835-17 0050 Cardiovascular disease ■ 18- 

Hydroxylase block in the 17 alpha-hydroxylase deficiency 

syndrome (human) 
ROlHL-10612-13 0018 Humoral factors in heart failure 

and hypertension - The pathogenesis of experimental renal 

hypertension (dogs, rabbits, rats) 
POIHL 11678-11 0001 Cardiovascular dynamics and their 

control - Body fluid volumes in the genesis of hypertension 

(rats, dogs) 

BODY FLUID BALANCE, IONIC, SALT GLAND 

ROlHL-16318-21 Biochemistry and pharmacology of Na-K 
transport 

BODY FLUID BALANCE, OSMOTIC PRESSURE 

SEE ALSO BLOOD OSMOTIC PRESSURE 
SEE ALSO CELL FLUIDS, OSMOTIC PRESSURE 
SEE ALSO SENSE ORGANS, OSMORECEPTORS 
** POlHL-06285-18 0199 Cardiovascular-respiratory 

physiology and biochemistry - Renal tubular reabsorption of 
sodium chloride (hamsters, rabbits) 
ROIHL 10881 13 Structure and function of 
microcirculation (hamsters, rats, cats, dogs) 
*• POlHL-11678-11 0027 Cardiovascular dynamics and their 
control - Vasopressin and thirst in control of body fluid 
volumes and osmolality (dogs) 
POlHL-1 1678-11 0035 Cardiovascular dynamics and their 
control - Lymph flow rate and protein concentration (dogs) 



72 



POlHL-1 1678-11 0036 Cardiovascular dynamics and their 

control - Pulmonary capillary dynamics and edema (dogs) 
POlHL-1 1678-11 0039 Cardiovascular dynamics and their 

control - Capillary and interstitial fluid dynamics of the 

intestine (cats) 
** POlHL-11678-11 0057 Cardiovascular dynamics and their 

control - Return of urine to circulation using cystico-caval 

shunt (dogs) 
POlHL-11678-11 0070 Cardiovascular dynamics and their 

control - Interaction of the four Starling forces (dogs) 
POlHL-121 57-11 0058 Functions and mechanisms of cell 

membrane ion transport - Ionic and osmotic regulation in 

toadfish -A euryhaline aglomerular teleost 
ROlHL-12792-09 Local control of the microcirculation 

(hamsters, rats) 
M ROlHL-12879-09 Pulmonary transport and metabolism in 

vivo 
** ROlHL-12879-09 0002 Pulmonary transport and 

metabolism in vivo - Osmotic compartmental model of 

barrior exchange 
P01HL-14388-07 0192 Regulation of the circulation in 

pathological states - Renal tubular secretion of magnesium 

(rats) 
ROlHL-15655-05 Blood flow and gas exchange in placenta 

and lungs (sheep) rabbits) 
P50HL-17665-04 0021 Study of ischemic heart disease - 

Identification, prevention-Myocardial ischemia in 

cardiopulmonary bypass (dog) 
ROlHL-18426-04 Regulation of renal hemodynamics (dogs) 
ROlHL-20080-02 Surgically induced myocardial edema 

(dogs) 
ROlHL-21376-02 Blood-gas barrier solute and water 

transport (rabbits) 
R23HL-22933-01 Transvascular fluid and protein exchange 

in the lung (sheep) 
ROlHL-23015-01 Mechanisms of hypo-oncotic pulmonary 

edema (human, dogs) 

BODY FLUID BALANCE, OSMOTIC PRESSURE, 
HYPEROSMOLARITY 

P50HL-17669-04 0006 Ischemic heart disease center 

(SCOR) - Studies of hypoxic, acidotic and ischemic cardiac 

muscle (dogs) 
P50HL-17669-04 0022 Ischemic heart disease center 

(SCOR) - Pathological studies of human and experimental 

ischemic heart disease 
ROlHL-17944-03 Studies in lung preservation (dogs) 
ROlHL-18590-03 Cerebral blood flow after cardiac arrest 

(dogs, monkeys) 
ROlHL-19030-03 Tissue protection during circulatory 

interruption (dogs) 
R23HL-21663-01 Regulation of collagen biosynthesis 

(chick, embryo) 

BODY FLUID BALANCE THERAPY 

SEE ALSO BLOOD TREATMENT, HEMODIALYSIS 
SEE ALSO NUTRITION, DIET THERAPEUTIC, SALT RESTRICTED 
R01HL-02363-20 Kinetics of water and electrolytes in 

shock (dogs, rats) 
ROlHL-13172-10 Post-trauma lung mechanics and fluid 
exchange (human, dogs, monkeys) 

BODY MOVEMENT DISORDERS 

SEE NEUROMOTOR DISORDERS 

BODY MOVEMENT SENSE 

SEE SENSORY-PERCEPTUAL PROCESSES, PROPRIOCEPTION 

BODY PHYSICAL CHARACTERISTICS (GENERAL) 

SEE ALSO SKELETAL DISORDERS DIAGNOSIS (INCL E)(AMS)* 
** P50HL-14136-07 0004 Pulmonary SCOR-Airways 

obstructive diseases - Morphometric studies of developing 

emphysema (human) 
P50HL-15103-07 0001 A/S SCOR-Early natural history of 

arteriosclerosis - Clinical research-Bogalusa heart study 

(children) 
** ROlHL-18639-03 Human anatomy for cardiac prostheses 

(human) 
ROlHL-19859-03 Epidemiological studies, precursors of 

hypertension (human) 
ROlHL-19864-03 0001 Blood pressure of children and 

young adults - Follow up of students from Dormont, 

Pennsylvania 
ROlHL-19869-03 Antecedents of adolescent hypertension 

(human) 
ROlHL-19870-03 Hypertensive progeny-Physical and 

humoral precursor search 
ROlHL-19956-03 High blood pressure in the young 

(human) 
ROlHL-19984-02 Blood pressure and immunogenetic 

factors in the young (human) 
ROlHL-20124-02 Coronary risk factors (human) 
ROlHL-20159-03 Genetic epidemiology of precursors of 

hypertension (human) 
NO lHV-530 10-03 NAS-NRC twin registry 

BODY POSITION SENSE 

SEE SENSORY-PERCEPTUAL PROCESSES. PROPRIOCEPTION 

BODY REGIONS (GENERAL) 

SEE ALSO ORAL-PHARYNGEAL (REGION) 
SEE ALSO SKELETAL SYSTEM. LIMB 
P01HL-13480-09 0017 Cardiac electrophysiology - Body 
surface potential mapping (human, dogs) 



BOD 

BODY REGIONS, ABDOMEN 

POlHL-14414-07 0007 Environmental influences on 

cardiorespiratory and cellular functions - Neural control of 

respiration (human, cats) 
POlHL-21584-02 0004 Respiratory mechanics In normal 

and abnormal states - Effects of anesthesia on respiratory 

mechanics (dogs) 

BODY REGIONS, THORAX 

SEE ALSO BODY CAVITIES, PLEURAL CAVITY 
SEE ALSO INJURIES, CHEST 

SEE ALSO RESPIRATORY FUNCTION, RESPIRATION, THORACIC 
PRESSURE 
** P01HL-14580-07 0003 Program project in respiratory 

mechanics - Chest wall mechanics and respiratory control 
(human, dogs) 
ROlHL-16292-05 0020 Surgery and non-obstructive 
coronary insufficiency - Limitation of transthoracic ECG in 
detecting subendocardial ischemia (dogs) 
** ROlHL-18639-03 Human anatomy for cardiac prostheses 
(human) 
P50HL-19170-02 0006 Harvard pulmonary SCOR-Chronic 

diseases of the airways - Mechanism of overdistension 
(human, animal) 
R01HL-19678-01 Quantification of intrathoracic fluid by 

impedance (human, dogs) 
R01HL-20110-02 Microwave methods of lung water 

measurement (dogs, phantom models) 
R23HL-21406-01 Respiratory muscles in regulation of 

infant breathing (human) 
POlHL-2 1584-02 0004 Respiratory mechanics in normal 
and abnormal states - Effects of anesthesia on respiratory 
mechanics (dogs) 

BODY TEMPERATURE 

SEE TEMPERATURE (BODY) 
BODY TEMPERATURE REGULATION 

SEE TEMPERATURE (BODY) REGULATION 

BODY VOLUME 

ROlHL-13172-10 Post-trauma lung mechanics and fluid 
exchange (human, dogs, monkeys) 

BODY WATER BALANCE 

SEE BODY FLUID BALANCE, BODY V<ATER 

BODY WATER EXCESS 

SEE BODY FLUID BALANCE, BODY WATER EXCESS 

BODY WATER LOSS 

SEE BODY FLUID BAUNCE, BODY WATER LOSS 

BODY WEIGHT 

SEE ALSO AGE (ANIMAL), INFANTS. BIRTH WEIGHT 
SEE ALSO GROW/TH AND DEVELOPMENT 
R01HL-01979-22 Arteriosclerosis in zoo animals on 

controlled diets (animals) 
ROlHL-03299-21 Dietary effects on cholesterol metabolism 

(rats, rabbits) 
POlHL-06835-17 0017 Cardiovascular disease - Studies 

on obese hypertensive rats 
POlHL-06835-17 0018 Cardiovascular disease - Fatty 

acid concentration (rats) 
POlHL-06835-17 0019 Cardiovascular disease - Fatty 

acid distribution (rats) 
POlHL-06835-17 0020 Cardiovascular disease ■ Lipid 

metabolism (rats) 
POlHL-06835-17 0024 Cardiovascular disease - Studies 

on the obese spontaneously hypertensive rat 
POlHL-06835-17 0046 Cardiovascular disease - Renin 

activity during salt depletion in essential hypertension 

(human) 
R01HL-U901-12 0019 Effects of metabolic surgery on 

the hyperlipidemias - Cholesterol, bileacids, lipoproteins in 

obese humans 
ROlHL-15174-06 CV disease epidemiology-Second 

generation studies (human) 
ROlHL-18040-04 Waveform dependency in defibrillation 

(calves) 
ROlHL-18235-03 Cardiovascular fitness and other risk 

factors (human) 
ROlHL-19858-03 UMMC-Blood pressure precursors and 

consequences (human) 
ROlHL-19864-03 0001 Blood pressure of children and 

young adults - Follow up of students from Dormont, 

Pennsylvania 
ROlHL-20629-02 Catheter ventricular defibrillation studies 

(dogs) 
ROlHL-22123-02 The role of the red cell in diabetic 

atherosclerosis (human) 

BODY WEIGHT, OBESITY 

SEE ALSO METABOLIC DISORDERS INBORN, OBESITY 

HEREDITARY HYPERGLYCEMIC 
SEE ALSO NUTRIENT INTAKE ACTIVITY, APPETITE 

DEPRESSANTS 
SEE ALSO NUTRITION, DIET THERAPEUTIC, REDUCING DIET 
R01HL-02063-23 Biochemistry and function of lipids and 
cell membranes (human, yeast, animals) 
** POlHL-06835-17 0017 Cardiovascular disease - Studies 
on obese hypertensive rats 
POlHL-06835-17 0018 Cardiovascular disease - Fatty 

acid concentration (rats) 

(contd) 



•Excludes routine methodotogy OR covers only general projects which preclude indexing at the specific level. 
**Oriented significantly to above subject. 



M Grant has subproiects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



P0tHl0683!> i; 0019 Ctidlovticulir dlMlsr Lilly 

icid distiibulion (latsl 
POIHl 0683!) 17 0020 Ctidlovisculai disaast liiiid 

matabolisni dais) 
POIH1.0683!> U 00.'4 Catdiovaicuiai disaas* Studias 

on tha obaja spontaneously liypertansiva lat 
ROIHl 09914 13 The inyocaidium in diabetes mellitus 
(dogs, inonkeys) 

Eltects ol metabolic surgery on 
Partial ileal bypass (human) 

Etiects ol metabolic surgery on 
Ellecl ot bypass on gasliin levels 



ROIHI 11901 U 0001 
the hyperlipidenuas 

ROIHL 11901 12 OOM 
the hyperlipidenuas 
(dogs, human) 

ROIHL 11901 12 0019 
the hyperlipidemias 
obese humans 

ROIHI 11901 12 0020 
the hyperlipidemias 



EMects ot metabolic surgery on 
Cholesterol, bileacids. lipoproteins in 



Ellects ol metabolic surgery on 
leiuno ileal bypass Endogenous 

animal model ol obesity (rats) 
ROIHL I208S 10 Lipoproteincarbohydtate ntetabolism 

(human, lats) 
ROIHL 1362606 Lipoprotein lipase and lipoprotein 

removal (human, rats, bjcteria) 
P50HL 14164 07 0041 A/S SCOR Comparative and 

experimental atherosclerosis Nonhuman primate pediatric 

atherosclerosis risk lactor 
P50HL 1423007 0088 A/S SCOR Lipids, atherosclerosis 

and thrombosis Coronary risk tactors in school children 

The Muscatine study 
P50HL 14236-05 0009 Prevention ol premature 

arteriosclerosis - Clinical studies on cholesterol metabolism 

(human) 
POIHL- 1498507 0004 Adaptation to hypoxia Control ol 

breathing in respiratory tailure (human, dogs) 
P01HL1498507 0009 Adaptation to hypoxia Inlluence 

ol chemosensitivity on control ol breathing during sleep 

(human, dogs) 
P50HL1510307 0001 A/S SCOR Early natural history ol 

arteriosclerosis Clinical research Bogalusa heart study 

(children) 
R01HL1677404 Genetic epidemiology ol hyperlipemia 

(Honolulu) 
P50HL- 183 18-03 0002 Pathogenesis and complications ol 

hypertension - Core experimental animal lacility (rats. 

rabbits) 
P50HL-19362-02 0002 A/S SCOR -Atherosclerosis in 

nonhuman primates - Inlant caloric intake, adipose tissue 

development and atherosclerosis (baboon) 
R01HL1987003 Hypertensive progeny-Physical and 

humoral precursor search 
R01HL19877-02 Prevention ol high blood pressure in 

children 
ROlHL-20159-03 Genetic epidemiology ol precursors ol 

hypertension (human) 
ROlHL-20439-02 Ellects ol insulin on neurovascular 

transmission (human, rats, rabbits, hamsters) 
ROlHL-21010-02 Glycemia. other traits and CV death in 

40.000 persons 
ROlHL-21416-02 Atherosclerosis in nev» modles o! 

diabetes mellitus 
R23HL-22345-02 0001 Behavioral cardiovascular 

compliance strategies - Long term modilication of dietary 

patterns (human) 
ROlHL-22378-01 Psyco-somatic predictors ol CHO in 

adolescence (human) 
** ROlHL-23201-01 Mechanisms of hypertension (human. 

rats) 
N01HV.12159-09 Lipid research clinic 
NOlHV-6295504 Data collection in clinical pathology and 

morbid anatomy (men) 

BOHR EFFECT 

SEE RESPIRATORY GAS LEVELS. BOHR EFFECT 

BOMBAY BLOOD GROUP 

SEE BLOOD GROUPS. BOMBAY 

BOMBESIN 

SEE ENDOCRINOLOGY. HORMONES. PEPTIDE-POLYPEPTIDE 
HORMONES 

BOND CLEAVAGE 

SEE CHEMICAL BONDS. BOND CLEAVAGE 
BOND FREQUENCIES 

SEE CHEMICAL BONDS, VIBRATIONS 
BONOS 

SEE CHEMICAL BONDS 
BONE 

SEE SKELETAL SYSTEM. BONE 
BONE CIRCULATION 

SEE SKELETAL SYSTEM CIRCUUTION 
BONE DENSITY 

SEE SKELETAL SYSTEM. BONE DENSITY 
BONE MARROW 

SEE BLOOD AND RE SYSTEM. BONE MARROW 

BONE MARROW DISORDERS 

SEE BLOOD AND RE DISORDERS, BONE MARROW 



73 

BONE MARROW OIANT CELLS 

SI I HIOIID AND Rl SYSIIM Ml liAMRYOCYIf S 

BONE MARROW LYMPHOCYTES 

sii moon cms, h iymcmocyiis 

BONE MARROW TRANSPLANTATION 

Slf BIOOO AND Rf SYSIIM, HON! MARROW 
IRANSPLANIAIION 

BONE NECROSIS 

S!l SKIiriAl DISORDERS, BONE NECROSIS 
BONE NECROSIS ISCHEMIC 

SEt SKIIFIAl DISORDERS, BONE NECROSIS ISCHEMIC 
BONE PROSTHESIS 

SFE SKELETAL TISSUE PROSTHESIS. BONE 
BONE SCANNING 

SEE SKELETAL VISUALIZATION, BONE SCANNING* 

BORANES 

SEE METALS. BORON COMPOUNDS, BORANES 

BOROHYDRIDES 

SEE METALS, BORON COMPOUNDS. BORANES 
BOVIDS 

SEE MAMMALS. ARTIODACTYLA, CAHLE* 
BOVINE SERUM ALBUMIN 

SEE ALBUMINS, SERUM ALBUMIN BOVINE 
BRADYCARDIA 

SEE HEART DISORDERS. ARRHYTHMIA, BRAOYCARDIA 
BRADYKININ 

SEE PEPTIDES, VASOACTIVE PEPTIDES, KALLIDIN 9 

BRADYKININ-ASSOCIATED HYPERTENSION 

SEE CARDIOVASCULAR DISORDERS, HYPERTENSION 
(SYSTEMIC), KININS-BRADYKININ-KALLIKREIN- 
ASSOCIATED 

BRAIN 

SEE ALSO CEREBROVASCULAR SYSTEM 

SEE ALSO CEREBROVASCUUR SYSTEM, CEREBRAL 

CIRCUUTION 
SEE ALSO NERVOUS SYSTEM CENTRAL 
SEE ALSO PITUITARY GLAND 
SEE ALSO SENSE ORGANS 
ROlHL-10384-13 Blood How and nucleotide metabolism 
(animals) 
** POlHL-14388-07 0207 Regulation ol the circulation in 

pathological states - Brain and renin-angiotension 
interaction in spontaneous hypertension (rats) 
R01HL-I8007-05 Neural mechanisms controling motor act 

ol breathing (cats, human) 
ROlHL-21471-02 Structurelunction studies on actin and 
myosin (human, protozoa, rabbits, cattle) 
** ROlHL-21969-01 Prevention of myocardial hypoxia during 
bypass (rats, mice, squirrels) 
R0)HL-22088-02 Metabolic basis for diabetic 
microangiopathy (cattle) 

BRAIN, AUDITORY CORTEX 

** POlHL-08899-14 0052 Tolerance to respiratory gases in 

health and disease - Oxygen effects on auditory and 
vestibular function (human, guinea pigs) 

BRAIN, BASAL GANGLIA, CAUDATE NUCLEUS 

POlHL-14388-07 0151 Regulation of the circulation in 

pathological states - Catecholamine release in potassium 

ion-free contractures in the caudal artery 
POlHL-14388-07 0152 Regulation of the circulation in 

pathological states - Ion flux alterations in caudal artery in 

SHR 
** POlHL-18974-03 0009 Experimental neurogenic 

hypertension program - Biochemistry ol brain tyrosine 

hydroxylase (rats) 
ROlHL-201 94-01 Brain catecholamines in control ol blood 

pressure (rats) 

BRAIN, BRAIN STEM 

POlHL-06835-17 0060 Cardiovascular disease - 

Ventricular performance experimental models of arterial 

hypertension (rats, dogs) 
POlHL-07896-15 0008 Environmental biomedical research 

program - Otologic studies under hyperbaric conditions 

(human, animals) 
POlHL-10342-13 0019 The integrated function of 

respiration and circulation - Cerebral circulation and 

metabolism (dogs) 
ROlHL-13187-09 Central neural control ol cardiovascular 

lunction (cats) 
POlHL-13851-16 Cyclotron produced isotopes in biology 

and medicine (human, animals) 
** ROlHL-13888-15 Regulation ol respiration 

ROlHL-16648-16 Integrated control ol cardiovascular 

activity (cats) 
** POIHL 16878-05 0003 Control of ventilation in health 

and disease - Brain stem respiratory neurons in response 

mechanical/chemical loading (animal) 
POlHL-16878-05 0004 Control of ventilation in health 

and disease - Neurotransmitters in the respiratory system 

(cats) 



'Excludes routine methodology OR covere only general projects which preclude indexing at the specific level. 
••Onented significantly to above subject. 



BRA 

NOIHl 1/90/04 llrain i«(ulilion ol caiditr tiihylhrnia 

(pi|i citi. rilt) 
POIHI 189/4 03 0001 liperimintal nturo|anic 

hypertention progiim Cantial naural tytlamt r«fulttin| 

■ rtariAl pre\iur« (rabbiti) 
P50H1 I9IB/0? 0011 Pgdiitiic pulmonary SCOR Hyalint 

membrane disease (lUcIt ol hypoiit and hyparcapnii on 

developing nervous system (monkey, human) 
ROIHL 20194 01 Brain catecholamines in control ol blood 

pressure (rats) 
" ROIHI 705/4 01 Brain slam integration ol chamoracaplof 

activity (cats) 
" ROIHI 20800 17 Neural basil ol ratpiralory and 

vasomotor activity (cats) 
ROIHL 21257 02 Breathing in sleep Airway control and 

blood gases (cats) 
R23HL 21914 01 Studies ol vasomotor control (rati) 
" R0IHL224I801 Neural control ol cardio respiratory 

lunction (cats) 

BRAIN, CENTRAL SPACES 

SEE ALSO NERVOUS SYSTEM CENTRAL. CEREBROSPINAL 
FLUID 
POIHL 14388 07 0207 Regulation ol the circulation in 

pathological states Brain and renin angiotension 
interaction in spontaneous hypertension (rats) 
ROIHL 2179901 Circumventricular sites ol pressor action 
ol angiotensin II (rats) 

BRAIN, CENTRAL SPACES, CEREBRAL 
VENTRICLES 

ROIHL 1932003 Angiotensin neuropharmacology 
Relationship to sodium 

BRAIN, CENTRAL SPACES, CHOROID PLEXUS 

** POlHL-08899 14 0054 Tolerance to respiratory gases in 

health and disease - Glucose transport across choroid 
plexus (dogs) 
ROlHL-1932003 Angiotensin neuropharmacology- 
Relationship to sodium 

BRAIN, CEREBELLAR CORTEX, PURKINJE CELLS 

POlHL-0789615 0008 Environmental biomedical research 

program - Otologic studies under hyperbaric conditions 
(human, animals) 

BRAIN, CEREBELLAR NUCLEI 

POlHL-16910-05 0007 Regulation ol the peripheral 

circulation - CNS~Behavioral inlluences on circulation 
(baboons) 
** R23HL-22747-01 Cardiodynamics and hypertension under 
cerebellar control (dogs) 

BRAIN, CEREBELLUM 

ROlHL-09913-13 Cerebral veins -Anatomic and radiologic 

correlation (human) 
POlHL-16910-05 0007 Regulation ol the peripheral 

circulation - CNS-Behavioral inlluences on circulation 

(baboons) 

BRAIN, CEREBRAL CORTEX 

SEE ALSO BRAIN, AUDITORY CORTEX 
SEE ALSO BRAIN ELECTRICAL ACTIVITY 
POlHL-07896-15 0030 Environmental biomedical research 

program - Narcosis caused by inert gases at raised 

pressures (human, animals) 
" POlHL-07896-15 0049 Environmental biomedical research 

program - Effects ol hyperbaric oxygen and pressure on 

cerebral enzymes (rats) 
POlHL-07895-15 0052 Environmental biomedical research 

program - Effects ol hypoxia on cerebral lunction 
ROlHL-11906-11 Comparative study of heart function 

(cats, rats, hedgehogs, squirrels) 
POlHL-14388-07 0193 Regulation of the circulation m 

pathological states - Ontogenesis ol central nervous system 

amines in hypertension (rats) 
RO1HL-18601-01 Regulation ol neurotransmitter release by 

adenosine (rats) 
R0IHL-18932-03 Brain microcirculation observed in vivo 

after trauma (mice) 
ROlHL-20500-02 Diabetic human brain microvascular 

basement membrane (human) 

BRAIN, CEREBRAL CORTEX, MOTOR CORTEX 

POlHL-06296-18 0007 Cardiovascular and pulmonary 

adaptation to stress - Cardiovascular control during 
isometric exercise (cats) 

BRAIN, CEREBRUM 

SEE ALSO BRAIN, LIMBIC SYSTEM 

SEE ALSO BRAIN. LIMBIC SYSTEM. SEPTAL AREA 

SEE ALSO BRAIN LESIONS SUR"" ' " 

POlHL-14388-07 0179 Regulation ol 1,,^ .,,.,.u,o ,. , 

pathological states - Cultured muscle cells and their cross- 
innervation in vitro (rats, sheep) 
** POlHL-14388-07 0180 Regulation ol the circulation in 

pathological states - Regulation of cerebral blood flow 
(dogs, monkeys) 
** ROlHL-19053-03 Vascular anatomy ol the telencephalon 
(human) 
ROlHL-21799-01 Circumventricular sites ol pressor action 
ol angiotensin II (rats) 

Icontd) 



M Grant has subprojects descnbing specific research aspects. 
See Appendix lor investigator's name and grant number 



BRA 

BRAIN, CEREBRUM, FRONTAL LOBE 

ROlHL-09913-13 Cerebral veins-Anatomic and radiologic 
correlation (human) 

BRAIN, CEREBRUM, HIPPOCAMPAL FORMATION 

ROlHL-09913-13 Cerebral veins-Anatomic and radiologic 

correlation (human) 
R01HL17800-04 Pulmonary reflexes -Central pathways 

(cats, dogs, rabbits) 

BRAIN, CEREBRUM, OCCIPITAL LOBE 

ROlHL-09913-13 Cerebral veins-Anatomic and radiologic 
correlation (human) 

BRAIN, CEREBRUM, ORBITAL GYRI 

ROlHL-02888 22 Interrelationships of circulation and 
respiration (opossum, cats) 

BRAIN, CEREBRUM, PARIETAL LOBE 

ROlHL-09913-13 Cerebral veins-Anatomic and radiologic 
correlation (human) 

BRAIN, DRINKING REGULATORY CENTERS 

POlHL-14388-07 0156 Regulation of the circulation in 

pathclogical states - Blood pressure with drinking to 
intracranial angiotensin II injections (rats) 

BRAIN, HYPOTHALAMUS 

SEE ALSO PITUITARY DIENCEPHALON (HORMONES) 
ROlHL-02888-22 Interrelationships of circulation and 

respiration (opossum, cats) 
ROlHL-06736-18 Biogenic-mechanical factors in 

microcirculation (rats, gerbils) 
POlHL-08682-15 0006 Regulation of the cardiovascular 

system - Cardiovascular studies of mammalian hibernators 

(sciuromorpha) 
POlHL-08682-15 0017 Regulation of the cardiovascular 

system - Neurally induced cardiac dysrhythmias (dog) 
POlHL-08682-15 0022 Regulation of the cardiovascular 

system - Blood pressure responses and preganglionic 

sympathetic outflow (cat) 
POlHL-10342-13 0019 The integrated function of 

respiration and circulation - Cerebral circulation and 

metabolism (dogs) 
ROlHL-13454-08 Behavioral stress and cardiomyopathy 

(monkeys, cats) 
P01HL-1438807 0193 Regulation of the circulation in 

pathological states • Ontogenesis of central nervous system 

amines in hypertension (rats) 
** ROlHL-14560-07 Hypertension produced by sympathetic 

dysfunction (human, rats) 
** ROlHL-15307-06 Central nervous control of renin and 

blood pressure (dogs) 
ROlHL-1631505 Analysis of interaction between CNS 

vasomotor systems (cats, rats) 
ROlHL-16648-16 Integrated control of cardiovascular 

activity (cats) 
POlHL-1691005 0007 Regulation of the peripheral 

circulation - CNS-Behavioral influences on circulation 

(baboons) 
** R01HL17907-04 Brain regulation of cardiac arrhythmia 

(pigs, cats, rats) 
ROlHL-1808503 

monkeys) 
ROIHL- 1860 1-01 

adenosine (rats) 
R01HL19144-03 Contraceptive steroids and experimental 

hypertension (rats) 
R01HL19209-03 Role of ADH in experimental renal 

hypertension (dogs, rats) 
ROIHL 20194-01 Brain catecholamines in control of blood 

pressure (rats) 
" ROlHL-22411-01 Neuroendocrine involvement in 

hypertension (rats) 

BRAIN, LIMBIC SYSTEM 

SEE ALSO BRAIN, CEREBRUI^, HIPPOCAMPAL FORMATION 
P01HL18974-03 0012 Experimental neurogenic 

hypertension program • Immunohistochemistry of central 
monoamine neurons (rats) 

BRAIN, LIMBIC SYSTEM, SEPTAL AREA 

** P01HL18974-03 0011 Experimental neurogenic 

hypertension program • Biochemistry and regulation of 
brain tryptophane hydroxylase (rats) 

BRAIN, MEDULLA OBLONGATA 

SEE ALSO BRAIN, RESPIRATORY CENTER 
POlHL-08805-15 0046 Regulation of ventilation and 

pulmonary circulation - Sites and modes of interaction of 

peripheral and central chemoreccptors 
ROlHL-13841 16 Respiration during altitude 

acclimatization (goats, dogs, rats, rabbits) 
POIHL 1498507 0009 Adaptation to hypoxia ■ Influence 

of chemosensitivity on control of breathing during sleep 

(human, dogs) 
ROlHL-15392-06 Autonomic and circulatory actions of 

anesthetics (dog, cat, rabbit, monkey) 
ROlHL'16648-16 Integrated control of cardiovascular 

activity (cats) 
ROIHL- 1768906 Neurophysiologic studies of respiratory 

control (cats) 
P01HL18974-03 0001 Experimental neurogenic 

hypertension program - Central neural systems regulating 

arterial pressure (rabbits) 



Neural factors in atherogenesis (squirrel 
Regulation of neurotransmitter release by 



74 

BRAIN, MEDULLA OBLONGATA, AREA 
POSTREMA 

ROIHL 22617-01 Angiotensin, hypertension and the CNS 
(sheep) 
BRAIN, MEDULLA OBLONGATA, SOLITARY 
TRACT NUCLEUS 

POlHL-14388-07 0193 Regulation of the circulation in 
pathological states - Ontogenesis of central nervous system 
amines in hypertension (rats) 

POlHL-18974-03 0006 Experimental neurogenic 
hypertension program - Model of sustained arterial 



hypertension (cats) 
POlHL-18974-03 0008 
hypertension program 
(rats) 



Experimental neurogenic 
Monoamines and hypertension 



BRAIN, MESENCEPHALON 

POlHL-14388-07 0183 Regulation of the circulation in 
pathological states - Vasopressin in cardiovascular 
regulation (dogs, rats) 

ROlHL-17903-03 Regional circulatory responses to hypoxia 
(rats, cats, rabbits) 

BRAIN, MESENCEPHALON, COLLICULUS 
INFERIOR 

ROlHL-19394-03 Biochemistry and regulation of taurine in 
the heart (rats, guinea pigs, cats) 

BRAIN, MESENCEPHALON, RAPHE NUCLEUS, 
DORSAL 

** POlHL-18974-03 0011 Experimental neurogenic 

hypertension program - Biochemistry and regulation of 
brain tryptophane hydroxylase (rats) 
POlHL-18974-03 0012 Experimental neurogenic 

hypertension program - Immunohistochemistry of central 
monoamine neurons (rats) 

BRAIN, PONS 

** POlHL-08682-15 0037 Regulation of the cardiovascular 

system - Central nervous regulation of cardiopulmonary 

mechanisms (cats) 
POlHL-14388-07 0183 Regulation of the circulation in 

pathological states - Vasopressin in cardiovascular 

regulation (dogs, rats) 
POlHL-16878-05 0003 Control of ventilation in health 

and disease - Brain stem respiratory neurons in response 

mechanical/chemical loading (animal) 
ROlHL-17689-06 Neurophysiologic studies of respiratory 

control (cats) 

BRAIN, PONS, TRIGEMINAL NUCLEUS (SPINAL) 

** POlHL-18974-03 0001 Experimental neurogenic 

hypertension program - Central neural systems regulating 
arterial pressure (rabbits) 

BRAIN, PROSENCEPHALON (GENERAL) 

** ROlHL-224 18-01 Neural control of cardiorespiratory 
function (cats) 

BRAIN, REGULATORY CENTERS (GENERAL) 

POIHL- 143 88-07 0229 Regulation of the circulation in 
pathological states - Mechanism of postural hypotension 
(human) 

BRAIN, RESPIRATORY CENTER 

SEE ALSO RESPIRATORY SYSTEM REFLEXES 
POlHL-11678-11 0009 Cardiovascular dynamics and their 
control - Control of respiration (cat. human) 
** ROlHL-13888-15 Regulation of respiration 

ROlHL-14102-07 Human physiology at 5360 meters- 
Mountain environment 
R01HL15659-05 Dynamic isolation studies of control of 
respiration (human) 
** ROlHL-16022-05 Determinants of the ventilatory response 

to hypoxia (goats, cats) 
** ROlHL-16430-05 Neural control of respiration (cats) 
POlHL-1687805 0003 Control of ventilation in health 
and disease - Brain stem respiratory neurons in response 
mechanical/chemical loading (animal) 
" POlHL-16878-05 0004 Control of ventilation in health 
and disease - Neurotransmitters in the respiratory system 
(cats) 
ROlHL-177 15-04 Respiratory muscle afferenfs In 
respiratory control (cats) 
** ROlHL-17800-04 Pulmonary reflexes-Central pathways 

(cats, dogs, rabbits) 
** P50HL-1919002 0006 Pulmonary SCOR -Pathophysiology, 
management of IRDS ■ Asphyxia-Respiratory control (dogs) 
ROlHL-205 74-03 Brain stem integration of chemoreceptor 
activity (cats) 
** ROlHL-20800-17 Neural basis of respiratory and 
vasomotor activity (cats) 
R23HL-21405-01 Respiratory muscles in regulation of 
infant breathing (human) 

BRAIN, RETICULAR FORMATION 

POlHL-10342-13 0019 The integrated function of 
respiration and circulation ■ Cerebral circulation and 
metabolism (dogs) 

ROlHL-21532-02 Cardiovascular homeostasis and learning 
(frogs, rats, human) 



BRA 

BRAIN, SUBCORTICAL STRUCTURES 

POlHL-07896-15 0029 Environmental biomedical research 
program Oxygen-helium diving resulting in high pressure 
nervous syndrome (human, animals) 

BRAIN, THALAMUS 

** ROlHL-22732-01 Central organization of cardiac afferent 
nerves (cats, monkeys) 

BRAIN, VISUAL PATHWAYS 

** POlHL-07896-15 0051 Environmental biomedical research 
program - Relationships of retinal circulation to disease 
(rabbits) 
.** POlHL-08899-14 0047 Tolerance to respiratory gases in 
health and disease - Oxygen effects on visual function 
(human) 

BRAIN CELLS 

ROlHL-04457-20 Cellular aspects of active transport (fish, 
rabbits, anurans, turtles) 

BRAIN CIRCULATION DYNAMICS 

SEE CEREBROVASCULAR SYSTEM. BRAIN CIRCULATION 

BRAIN CONCUSSION 

SEE BRAIN INJURY 

BRAIN CONTROL 

SEE PSYCHOLOGY, BRAIN CONTROL 

BRAIN DEATH 

SEE DEATH, CEREBRAL 

BRAIN DISORDERS 

SEE ALSO CEREBROVASCULAR DISORDERS 

SEE ALSO CONGENITAL ABNORMALITIES, BRAIN (GENERAL) 

SEE ALSO NERVOUS DISORDERS, MYELINOPATHIES 

(GENERAL) 
SEE ALSO NERVOUS DISORDERS CENTRAL (GENERAL) 
SEE ALSO NEUROMOTOR DISORDERS, PARKINSON'S DISEASE 
SEE ALSO PSYCHOLOGY ABNORMAL, MENTAL DISORDERS 
(GENERAL) 
POlHL-13851-16 Cyclotron produced isotopes in biology 
and medicine (human, animals) 

BRAIN DISORDERS, BRAIN EDEMA 

P01HL06285-18 0147 Cardiovascular-respiratory 

physiology and biochemistry - Metabolic regulation of 

cerebral microcirculation (cats) 
ROlHL-16643-02 Fluorocarbon emulsions as artificial 

blood (animals) 
R13HL-20765-01 Eleventh Princeton Conference on 

Cerebrovascular Disease (new jersey) 

BRAIN DISORDERS, CEREBELLAR DISORDERS 

ROlHL-09913-13 Cerebral veins-Anatomic and radiologic 
correlation (human) 

BRAIN DISORDERS, CEREBRAL ATROPHY 
DIFFUSE, SENILE DEMENTIA 

** POlHL-07896-15 0055 Environmental biomedical research 
program - Cerebral blood flow by Xenon-133 inhalation 
(human) 
NOlHV-52971-06 Reexamination of Framingham heart 
study cohort 

BRAIN DISORDERS, EPILEPSY 

SEE ALSO NEUROMOTOR DISORDERS, CONVULSIONS 
ROlHL-19394-03 Biochemistry and regulation of taurine in 

the heart (rats, guinea pigs, cats) 
ROlHL-21756-11 Vascular disease-Cytochemistry and 

ultrastructure (human, rats, mice, hamsters) 

BRAIN DISORDERS CONGENITAL 

SEE CONGENITAL ABNORMALITIES, BRAIN (GENERAL) 

BRAIN EDEMA 

SEE BRAIN DISORDERS, BRAIN EDEMA 

BRAIN ELECTRICAL ACTIVITY 

SEE ALSO BRAIN DISORDERS, EPILEPSY 
POlHL-08899-14 0006 Tolerance to respiratory gases in 

health and disease - Effects of extreme pressures of inert 
gases in macaque monkey 
** POlHL-08899-14 0013 Tolerance to respiratory gases in 

health and disease - Oxygen and carbon dioxide effects 
upon human brain metabolism 
** POlHL-08899-14 0022 Tolerance to respiratory gases in 
health and disease - Effect of inert gas and hydrostatic 
pressures on physiological functions (monkey) 
** P50HL-142 14-07 0032 Newborn lung center for hyaline 
membrane disease - Evoked electroencephalographic 
potential in infants with HMD (human) 
POIHL 14388-07 0183 Regulation of the circulation in 

pathological states - Vasopressin in cardiovascular 
regulation (dogs, rats) 
ROlHL-1643005 Neural control of respiration (cats) 
ROIHL 17715-04 Respiratory muscle afferents in 
respiratory control (cats) 
** P50HL-19187-02 0011 Pediatric pulmonary SCOR-Hyaline 
membrane disease - Effects of hypoxia and hypercapnia on 
developing nervous system (monkey, human) 

BRAIN INJURY 

SEE ALSO INJURIES, HEAD AND NECK 
** ROlHL-18932-03 Brain microcirculation observed in vivo 
after trauma (mice) 

(contd) 



•Excludes routine mcthodokigy OR covers onty general projects which preclude indexing at the specific level. 
**Onented significantly lo above subject. 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



Human ventilatoiy adaptation (also, 
Reactions ot hemeproteins and oxygen 



BRA 

BRAIN INTERHEMISPHERIC ACTIVITY, CEREBRAL 
DOMINANCE 

PbONl I4.M4 0/ 0013 Nawboin lung center lor hyillne 

membrane disease Developmental outcome ol children 
who had HMD as infants 

BRAIN ISCHEMIA AND HYPOXIA 

Sn CCREBROVASCUIAR DISORDFRS. BRAIN ISCHEMIA AND 

HYPOXIA 

BRAIN LESIONS SURGICAL 

** ROIHL 1790/04 Brain regulation ol cardiac arrhythmia 
(pigs. cats, rats) 

BRAIN LESIONS SURGICAL, CEREBELLECTOMY 

ROIHL 09913 13 Cerebral veins Anatomic and radiologic 
correlation (human) 

BRAIN LESIONS SURGICAL, DECEREBRATION 

POIHL 06296 18 0007 Cardiovascular and pulmonary 

adaptation to stress Cardiovascular control during 
isometric exercise (cats) 

BRAIN MAPPING 

ROIHI 21257 02 Breathing in sleep Airway control and 
blood gases (cats) 

BRAIN METABOLISM 

ROIHL'02477 23 Biosynthesis and function of lipids 

(microorganisms, rats) 
•• P01HL08899-14 0055 Tolerance to respiratory gases in 

health and disease Oxygen effects on organ functions - 

Extension of tolerance 
ROIHL'14020'06 Characterization of myosin from blood 

platelets (rabbit) 
P50HL 1421807 0018 Pulmonary SCOR-Newborn lung 

center Whole body buffering in acute hypercapnia (dogs) 
ROIHL 15469-06 

dogs, rats) 
ROIHL 1598006 

(cattle) 
ROlHL.16828-04 Gradient and transport of oxygen in 

tissue and organs (mammals) 
R01HL1856703 A routine diagnostic test for minimal 

heart damage (human, rat) 
*• POlHL-18974-03 0010 Experimental neurogenic 

hypertension program - Biochemistry and regulation of 

PNMT in brain (rats) 
ROIHL 18994-03 Substance P-Occurrence, pharmacology 

and physiology (mammals non-human, human) 
P50HL-19190-02 0006 Pulmonary SCOR -Pathophysiology. 

management of IRDS - Asphyxia-Respiratory control (dogs) 
** P50HL-1919002 0007 Pulmonary SCOR-Pathophysiology. 

management of IROS - Asphyxia-Cerebral metabolism (dog, 

rat) 
ROlHL-20194-01 Brain catecholamines in control of blood 

pressure (rats) 
ROlHL-20317-02 Procoagulant lipoproteins-Biochemistry 

and bioactivity (goats, rabbits) 

BRAIN NEOPLASMS 

SEE NEOPLASMS OF BRAIN 
BRAIN OSCIUOGRAPHY 

SEE BRAIN ELECTRICAL ACTIVITY 
BRAIN SCANNING 

SEE BRAIN VISUALIZATION, BRAIN SCANNING* 
BRAIN STEM 

SEE BRAIN, BRAIN STEM 

BRAIN STIMULATOR (PACEAAAKER) 

SEE BRAIN STIMUUTORS ELECTRONIC 

BRAIN STIMULATORS ELECTRONIC 

R01HLI1153-12 Quantitation of flov» and solute flux in 

microvessels (cats, rats) 
POlHL-1273810 0042 Physiologic pharmacology and its 

clinical applications - Centrogenic cardiac arrhythmias 

(cats) 
R01HL13454-08 Behavioral stress and cardiomyopathy 

(monkeys, cats) 
R01HL1456007 Hypertension produced by sympathetic 

dysfunction (human, rats) 
ROlHL-15562-05 Regulation of skeletal muscle blood flow 



(dogs) 
ROlHL-17907-04 

(pigs, cats, rats) 
R01HL18085 03 

monkeys) 



Brain regulation of cardiac arrhythmia 
Neural factors in atherogenesis (squirrel 



BRAIN TUMOR 

SEE NEOPUSMS OF BRAIN 

BRAIN VISUALIZATION, BRAIN SCANNING* 

POlHL-04664-18 0009 Cardiovascular and lung dynamics 
- Biological signal and image processing techniques (dogs) 

ROlHL-0991313 Cerebral veins-Anatomic and radiologic 
correlation (human) 
** POlHL-13851-16 Cyclotron produced isotopes in biology 
and medicine (human, animals) 



*E>dudes routine me(hodok>gy OR covers only general projects which preclude Indexing 
**Oneiited significantly to above subject. 



75 

BRAIN VISUALIZATION, ULTRASONIC 
ECHOENCEPHAIOORAPHY* 

ROIHI 16260 04 Oiwrluiinirnt of clinical cine ultrasound 
rnrdiogiaphy 

BRAIN WAVE DETERMINATION OF DEATH 

SfF OfATH. CFRFBRAl 

BRAN, DIETARY 

SEE NUTRITION. DIETARY CONSTITUENTS, DIETARY RESIDUES 
FIBERS 

BRANCHED CHAIN AMINO ACIDS 

SFF AMINO ACIDS, BRANCHED CHAIN AMINO ACIDS 
BRAZIL 

SEE GEOGRAPHICAL SITES, S AMERICA, BRAZIL 
BREAST NEOPLASMS 

SEE NEOPLASMS OF REPRODUCTIVE SYSTEM, BREAST 
NEOPLASMS 

BRETYLIUM 

SEE PHENYULKYUMINES, BENZYLAMINES. BRETYLIUM 
lOSYWTE 

BROMINE RADIOISOTOPES 

SEE RADIOISOTOPES, BROMINE 

BROMOCH LOROTRIFLUOROETHANE 

SEE HALOALKANES, HALOTHANE 
S-BROMODEOXYURIDINE 

SEE HALOPYRIMIDINE NUCLEOSIDES, HALOURACIL 
NUCLEOSIDES, 5 BROMODEOXYURIDINE 

BROMSULPHTHALEIN 

SEE BENZOFURANONES, PHTHALIOES, BROMSULPHTHALEIN 
BRONCHI 

SEE RESPIRATORY SYSTEM, BRONCHI 
BRONCHIAL ASTHAAA 

SEE HYPERSENSITIVfTY, RESPIRATORY HYPERSENSITIVITY, 
ASTHMA 

BRONCHIAL CIRCULATION 

SEE RESPIRATORY CIRCUUTION, BRONCHIAL CIRCULATION 
BRONCHIAL DISORDERS (GENERAL) 

SEE RESPIRATORY DISORDERS, BRONCHIAL DISORDERS 
(GENERAL) 

BRONCHIAL MUCUS 

SEE RESPIRATORY SYSTEM, BRONCHIAL MUCUS 

BRONCHIAL NEOPLASMS (GENERAL) 

SEE NEOPLASMS OF RESPIRATORY SYSTEM, BRONCHIAL 
NEOPLASMS 

BRONCHIECTASIS 

SEE RESPIRATORY DISORDERS, BRONCHIECTASIS 
BRONCHIOLE 

SEE RESPIRATORY SYSTEM, BRONCHIOLE 
BRONCHITIS ACUTE 

SEE RESPIRATORY DISORDERS. BRONCHITIS ACUTE 

BRONCHITIS CHRONIC AND EMPHYSEAAA 

SEE RESPIRATORY DISORDERS, BRONCHITIS CHRONIC AND 
EMPHYSEMA 

BRONCHOCONSTRICTORS 

SEE RESPIRATORY DRUGS, BRONCHOCONSTRICTORS 
BRONCHO DILATORS 

SEE RESPIRATORY DRUGS, BRONCHODILATORS 
BRONCHOGRAPHY 

SEE RESPIRATORY VISUALIZATION, BRONCHOGRAPHY* 
BRONCHOMOTION 

SEE RESPIRATORY FUNCTION. BRONCHOMOTION 
BRONCHOPULMONARY LAVAGE 

SEE RESPIRATORY ASSIST AND OXYGEN ADMINISTRATION, 
PULMONARY LAVAGE 

BRONCHOSCOPY 

SEE RESPIRATORY VISUALIZATION, BRONCHOSCOPY* 
BRONCHOSPASM 

SEE RESPIRATORY DISORDERS. BRONCHOSPASM 
BROWNING REACTION 

SEE CHEMICAL REACTIONS. BROWNING REACTION 
BRUSH BORDER MEMBRANES 

SEE MEMBRANE. BRUSH BORDER MEMBRANES 
BUFADIENOLIDES 

SEE CARDIAC GLYCOSIDES AGLYCONES. BUFADIENOLIDES 
BUFFERS 

SEE ACIDS-BASES, BUFFERS 
BUNDLE BRANCH BLOCK 

SEE HEART DISORDERS, ARRHYTHMIA, HEART BLOCK. 
BUNDLE BRANCH 

at the specific level. 



M Grant has subprojects descnbing specific research aspects. 
See Appendix tor investigator's name and grant number. 



CM 

BUNOU OF HIS 

SI I HIARI CONDUCTION SYSTFM. BUNDII OF Hl^ 

BURN THERAPY 

SI I IHIHAPY. BURN IHIRAPY 

BURNS 

Sir INIUKItS. BURNS 
BURNS, ELECTRICAL 

SFf INIURIIS. BURNS. ElFCTRICAl 
BURSA DEPENDENT IMMUNE SYSTEM 

Sri IMMUNITY, HIJMORAI IMMUNIIY 

BUTANOL, BUTYL ALCOHOL 

SEE ALCOHOLS. BUTANOL 

BUTYRIC ACID 

SEE FAHY ACIDS. BUTYRIC ACID 

BUTYRYLCHOLINESTERASE 

SEE CHOLINE ESTERASES 
BYPASS ARTERIOVENOUS ABNORMAL 

SEE CARDIOVASCULAR DISORDERS. ARTERIOVENOUS SHUNTS 
ABNORMAL 

BYPASS ARTERIOVENOUS NORMAL 

SEE CARDIOVASCULAR SYSTEM. ARTERIOVENOUS 
ANASTOMOSIS NORMAL 

BYPASS CARDIOVASCULAR ABNORMAL 

SEE CONGENITAL ABNORMALITIES. CARDIOVASCULAR SHUNTS 
ABNORMAL 

BYPASS CARDIOVASCULAR SURGICAL 

SEE CARDIOVASCULAR SURGERY. CARDIOVASCULAR SHUNTS 
BYPASS COLLATERAL CIRCULATION NORMAL 

SEE CARDIOVASCUUR SYSTEM. BLOOD SUPPLY, COLLATERAL 
CIRCULATION 

BYPASS CORONARY 

SEE HEART REVASCULARIZATION, CORONARY BYPASS 

BYPASS DUCTUS ARTERIOSUS EMBRYONIC 

SEE CARDIOVASCULAR SYSTEM, DUCTUS ARTERIOSUS 
EMBRYONIC 

BYPASS HEART EXTRACARDIAC ABNORMAL 

SEE CONGENITAL ABNORMALITIES, CARDIOVASCUUR SHUNTS 
ABNORMAL 

BYPASS HEART INTRACARDIAC ABNORMAL 

SEE CONGENITAL ABNORMALITIES, HEART SEPTAL DEFECTS 
BYPASS HEART-LUNG 

SEE CARDIOVASCULAR SURGERY, CIRCULATORY ASSIST. 
HEART-LUNG BYPASS 

BYPASS HEART SURGICAL 

SEE CARDIOVASCUUR SURGERY, CIRCUUTORY ASSIST. 
HEART BYPASS SURGICAL 

BYSSINOSIS 

SEE RESPIRATORY DISORDERS, BYSSINOSIS 
C 

SEE IMMUNOLOGY, COMPLEMENT 
CACHEXIA, PITUITARY 

SEE PITUITARY GUND DISORDERS, HYPOPfTUITARISM 
CADAVER (TISSUE) 

SEE DEATH. CADAVER (TISSUE) 
CADMIUM (COMPOUNDS) 

SEE METALS, HEAVY METALS, CADMIUM 
CAFFEINE 

SEE PURINES, XANTHINES, CAFFEINE 
CALCIFICATION INHIBITORS (CALCIUM 
NEGATIVE BALANCE DRUGS) 
P50HL-14230-07 0094 A/S SCOR-Lipids, atherosclerosis 
and thrombosis - Studies of atherosclerosis and regression 
(monkeys) 
P60HL15999-05 0021 Miami comprehensive sickle cell 
center - Diphosphonates-Erythrocyte calcium loading, 
maturation (human, chick embryo) 

CALCIFICATION PATHOLOGIC 

SEE CALCIUM (MINERAL) IMBAUNCES, CALCIFICATION 
PATHOLOGIC 

CALCIFICATION PHYSIOLOGIC 

SEE CALCIUM (MINERAL) BAUNCE, CALCIFICATION 
PHYSIOLOGIC 

CALCINOSIS 

SEE CALCIUM (MINERAL) IMBAUNCES, CALCIFICATION 
PATHOLOGIC 

CALCITONIN 

SEE THYROID HORMONES, (THYROjCALCFTONIN 
CALCIUM 

ROlHL-00340-29 Electrolyte disturbance in cardio-renal 

disease (human, dogs, rats) 
ROlHL-02212-23 Coagulation ot blood (human) 

(contd) 



BRA 



Micropuncture study of kidney function 



Biocfiemistry of contractile proteins 



ROlHL-02334-23 
(rats, animals) 
ROlHL-05883-18 0001 Reflex control of resistance and 

capacitance vessels ■ Naturally occurring uasoactiue 
substances and the vascular neuroetfectors (dog) 
ROlHL-05883-18 0002 Reflex control of resistance and 
capacitance vessels - Adenosine, adenine nucleotides and 
vascular smootti muscle (dog) 
ROlHL-05949-18 Biochemistry of muscle contraction (rats, 

rabbits) 
POlHL-06285-18 0195 Cardiovascular-respiratory 
physiology and biochemistry - Thyroid thermogenesis and 
sodium transport (rats) 
POlHL-06308-18 0039 Mechanisms and therapy of 

circulatory disease - ANS in regulation of electrophysiology- 
Role of cyclic nulceotides (animals) 
POlHL-06312-17 0051 Surgical cardiology ■ Diuretic 

therapy on myocardial electrolyte composition and water 
content (human) 
POlHL-06314-17 0047 Immunologic mechanisms in 
cardiovascular disease - Role of intravascular coagulation 
(human, animals) 
POlHL-06314-17 0054 Immunologic mechanisms in 

cardiovascular disease • Physiology of cell communications 
(mice, frogs, guinea pigs) 
POlHL-0631417 0057 Immunologic mechanisms in 

cardiovascular disease - Antigens in cardiovascular disease 
(human) 
ROlHL-09283-14 Pharmacology of molluscan hearts (also 

rabbits) 
ROlHL-09544-12 
(animals) 
* ROlHL-09906-13 0025 Membrane transport processes in 
red blood cells - Mechanism of propranolol induced Ca- 
dependent K efflux from human RBCs 
ROlHL-10384-13 Blood flow and nucleotide metabolism 

(animals) 
ROlHL-1089712 Effects of hormones on cardiac 

electrogenesis (rabbits, guinea pigs, dogs) 
R01HL10942-09 Study of genetic hypertension in rats 
POlHL-1 1307-12 0003 Biophysical studies in pediatric 

cardiology - Cellular biophysics (animals) 
POlHL-11351-12 0018 Cellular and molecular 

mechanisms of myocardial function - Quantitative 
localization of electrolytes in cardiac tissue 
ROlHL-1 1906-11 Comparative study of heart function 

(cats, rats, hedgehogs, squirrels) 
POlHL-12157-11 0038 Functions and mechanisms of cell 

membrane ion transport - Mechanisms and interactions of 
gases and ions with bilayer membranes (human) 
ROlHL-12486-10 Structure-function correlation in the 

atrium (rabbits) 
ROlHL-12528-10 
ROlHL-12820-09 

activation 
ROlHL-12997-07 Myocardial defects induced by potassium 

depletion (human, rats, cats) 
ROlHL-13198-21 Blood coagulation -Physico-chemical 

properties (human, cattle) 
ROlHL-13257-09 Inhalation anesthesia on myocardial 

metabolism (dogs, swine, human) 
POlHL-13262-07 0016 Arterial wall in atherosclerosis - 
Lipids in elastin preparations from atherosclerotic plaques 
(human, animals) 
ROlKL-13349-06 Analysis of activation process in heart 

muscle (guinea pigs, rabbits, human) 
ROlHL-14020-06 Characterization of myosin from blood 

platelets (rabbit) 
P50HL-14147-08 0003 Specialized center of research in 
thrombosis - Surface thrombogenicity and phospholipid 
vesicle physical properties 
P50HL-14147-08 0013 Specialized center of research in 

thrombosis - Mathematical models of blood coagulation 
kinetics 
P50HL-14230-07 0097 A/S SCOR -Lipids, atherosclerosis 

and thrombosis - Studies of circulating platelet aggregates 
(human) 
•* POlHL-14388-07 0153 Regulation of the circulation in 

pathological states - Subcellular distribution of calcium 
(rats) 
ROlHL-14461-08 Cardiac metabolism in heart failure 

(rats) 
ROlHL-14483-08 Energy conservation in heart 

mitochondria (cattle, E coli, human) 
ROlHL-14523-07 Generation and regulation of force in 

smooth muscle (animals) 
ROIHL 14614-07 Voltage control of contraction in heart 

(sheep) 
ROlHL-14820-07 Factors affecting physiology of biological 

membranes (human) 
ROlHL-14890-07 Platelet prostaglandins (human, rabbits) 
ROlHL-14899-07 Mechanism and prevention of cardiac 

arrhythmias (dogs) 
R01HL-14903-07 A new index of cardiac contractility 

(human, dogs, baboons) 
ROlHL-15013-07 Lung oxidative metabolism and energy 

production (rodents, rabbits) 
ROIHL 15391-07 EPR studies on rotational motion of 

myosin and actin 
ROlHL-15498-06 Effects of physical training on heart 
(rats) 



NMR relaxation of liquid crystal systems 
In vitro regulation of prothrombin 



76 

ROlHL-15512-06 Drug treatment of stenosing primate 

atherosclerosis (rabbits, monkeys) 

ROlHL-15728-06 The carbohydrate of the blood-clotting 

glycoproteins (mammals) 

ROlHL-15740-06 In vitro studies on heart cell function 

(rats) 

* ROlHL-15799-04 Effect of anesthetics on myocardial 

function (cats) 
POlHL-15832-06 0012 Chemical-structural predispositions 

to lung injury - Contractile structures and contractility in 

cells of lung respiratory tract 
POlHL-15835-06 0001 Study of muscles related to heart 

disease - Control of contraction-relaxation of heart and 

muscle (rabbits, chickens) 
POlHL-15835-06 0011 Study of muscles related to heart 

disease - Energetics and mechanism of muscle contraction 

(frogs, rabbits) 
POlHL-15835-06 0012 Study of muscles related to heart 

disease - Contraction and energetics of visceral and 

vascular smooth muscles (rabbits) 
POlHL-15835-06 0013 Study of muscles related to heart 

disease - Cardiac bioenergetics (rats) 

* POlHL-15835-06 0018 Study of muscles related to heart 

disease Pharmacology of excitation coupling in muscle 

(frog, barnacles) 
POlHL-1 5835-06 0023 Study of muscles related to heart 

disease - Cellular basis of the Frank-Starling curve (frogs, 

rats) 
ROlHL-15852-06 Vascular ion transport and hypertensive 

mechanisms 
ROlHL-15887-05 Enzymes of blood coagulation and 

fibrinolysis (human) 
ROlHL-16010-16 Cellular basis of cardiac contractility 

(frogs) 
POlHL-161 17-05 0002 Ion movements and membranes in 

cardiovascular control - Fluorescence and excitation- 
contraction coupling in heart (frogs) 
** POlHL-161 17-05 0003 Ion movements and membranes in 

cardiovascular control - Fast kinetic study of calcium 

membrane interactions 
** POlHL-161 17-05 0005 Ion movements and membranes in 

cardiovascular control - Properties of isolated cell 

membranes (rabbits, cats) 
POlHL-161 17-05 0007 Ion movements and membranes in 

cardiovascular control - Physiological and molecular 

properties of ionophores (dogs, rabbits) 
R01HH6346-09 Enzyme assay for blood clotting (human) 
ROlHL-16421-08 Determinants of RBC deformability and 

capillary flow (human, mice) 
** ROlHL-16436-04 

function (rats) 



Role of calcium and thyroxine in heart 
Contraction in heart and other striated 
Intrarenal regulation of sodium 



ROlHL-16606-11 

muscles (frogs) 
ROlHL-166 58-05 

reabsorption 
ROlHL-16660-06 Phospholipid-cholesterol and 

phospholipid-protein interactions 
ROlHL-16678-03 Fluorescent probe studies of heart 

muscle proteins (rabbit, dog) 
POlHL-16683-04 0002 Function and growth of cardiac 

and skeletal muscle - Myosin, actin. ATP, interaction in 

solution 
ROlHL-16746-04 Design of ion-selective molecules 
POlHL-16833-04 0014 Hemoglobin and red cell system in 

hemoglobinopathies - Erythrocyte membrane damage in Hb 

SS disease (human) 
R01HL17322-04 Functional characteristics of smooth 

muscle isolated from lung (animals) 
ROlHL-17335-05 Contractile properties of hypertensive 

arterioles (rats) 
POlHL-17430-05 0005 Control of coagulation - The 

activation of prothrombin (human, cattle, dogs) 
ROlHL-17451-05 Digitalis effects on cardiac automaticity 

mechanisms 
ROIHL 17721-04 Effect of sex hormones on vascular 

connective tissue (rats) 
ROlHL-17729-04 Stimulus-response coupling in platelets 

(human) 
ROlHL-18032-03 Development of normal and myopathic 

mammalian heart (hamsters) 
ROIHL- 180 50-04 Mechanisms of cardiovascular 

teratogenesis (chick embryo) k embryo) 
ROlHL-18070-04 Regulation of intrapulmonary airways 

and vessels (human, animals) 
ROlHL-18148-04 Adrenal catecholamine secretion 
ROlHL-18199-03 Effects of ions on vascular reactivity 
P01HL-18208-04 0001 Center for the study of blood cell 

rheology - Physiological basis of reversible erythrocyte 

shape change (human, firefly) 
POlHL-18208-04 0007 Center for the study of blood cell 

rheology - RBC membrane protein (human) 
* ROlHL-18255-04 Lipid-protein interactions and calcium 

transport (models) 
ROlHL-18280-03 Regulation of cardiac contractility and 

metabolism (rats) 
ROlHL-185 16-03 Atherosclerosis and the arterial 

contractile proteins (pigs, rabbits) 
ROlHL-18554-03 Taurine metabolism in mammalian heart 

(rodents, cattle, swine) 
ROlHL-18612-03 

(cattle) 



•Excludes routine methodotogy OR covers only general projects which preclude 
"Onented sitnificanthi to above subiect 



ROlHL-18737-03 
ndexing at the specific level. 



Thin filament control of heart contraction 
Human erythrocyte membrane structure 



CAL 

POlHL-18827-02 0007 Platelet vessel wall interactions in 

thrombogenesis - Biochemistry and role factor V in 
thrombogenesis (human, cattle) 
ROlHL-18834-04 Metal-dependent complex formation in 

blood coagulation (human, cattle) 
ROlHL-18852-03 Biochemical studies on the blood 

coagulation process (human, cattle) 
ROlHL-18937-03 Cyclic nucleotides and calcium in 

platelets (human) 
ROlHL-19012-03 Smooth muscle of resistance vessels in 

hypertension (rats) 
ROlHL-19072-03 Modification of tissue injury in 

myocardial infarction (dogs, human) 
ROlHL-19138-03 Contractile activation of skinned cardiac 

cells (mammals) 
ROIHL 19148-03 Myocardial organelle lipid structure and 

function (dog. rat) 
ROlHL-19252-02 Vascular connective tissue -Role in 

atherosclerosis (rabbits) 
R01HL-19324-02 Mechanisms of the inhibition of sickling 

by DBA (human) 
ROlHL-19378-03 Relation of mitochondrial changes to 

cardiac failure (dogs, rats) 
ROlHL-19414-03 Protection of myocardium during cardiac 

surgery (dogs, cats, human) 
R23HL-19501-01 Cardiac response to chronic metabolic 

acidosis (rats) 
POlHL-19737-02 0004 Cellular and molecular aspects of 

respiratory physiology - Rapid reactions and erythrocyte 
exchanges of blood during respiratory transport 
ROlHL-19848-02 Contractile activation by rapid 

temperature jumps (frogs) 
ROlHL-19982-02 Blood coagulation-Protein-metal ion-lipid 

interactions 
ROlHL-20079-02 0001 Thromboresistant material - Active 

and passive thromboresistant surfaces 
ROlHL-20087-02 Developmental processes in pulmonary 

hypertension (rats) 
ROlHL-20161-02 Role of gamma-carboxyglutamic acid in 

blood coagulation (human, cattle) 
ROlHL-20190-02 Pathogenesis of cardiac hypertrophy 



(dogs) 
ROlHL-20196-02 

muscle 
ROlHL-20319-02 

fibrin (human) 
ROlHL-20369-03 
ROlHL-20464-01 



Regulation of coronary arterial smooth 
Assembly, structure and interactions of 



The effect of alcohol on the heart (rats) 
Regulation of cardiac and skeletal 

muscle contraction (mammals) 
P01HL-20552-02 0003 The development and regression of 

cardiac hypertrophy - Muscle mechanics of the 

hypertrophied left ventricle (rats) 
POlHL-20592-02 0004 Cell biology of cardiac and 

skeletal muscle - Excitation, conduction and contraction- 
Modelling in Purkinje fibers 
POlHL-20592-02 0013 Cell biology of cardiac and 

skeletal muscle - Sarcoplasmic reticulum in skinned 

muscle cells (frogs) 
ROlHL-20643-02 Analysis of heart cell contraction (rats) 
ROlHL-20720-02 Myocardial protection during 

cardiopulmonary bypass (dogs) 
ROlHL-20725-02 

transport 



Mechanisms and cellular functions of ion 
Coronary flow regulation by adenosine 



ROlHL-20782-01 

(rats, dogs) 
ROlHL-20882-02 Interactions of plasma lipoproteins with 

erythrocytes (Rhesus, human) 
ROlHL-20902-02 Studies on marginal band system of 

erythrocytes (amphibians, reptiles, fish) 
ROlHL-20956-02 Early events following stimulation of 

human platelets 
POlHL-20984-02 0004 Cellular mechanisms in cardiac 

hypertrophy - Myofibril accumulation in cardiac and 
vascular muscle cells in hypertrophy 
POlHL-20993-02 0007 Population dynamics of arterial 

cells in atherogenesis - Interaction of lipoproteins in 
hypercholesteremia (human, swine) 
ROlHL-21 103-01 Parametric mechanical studies of 

hypertensive arteries (dogs, rats) 
ROlHL-2 11 39-02 Molecular biology of factor XIII (human) 
ROlHL-21145-02 Response of atria to hyperosmolality- 

Mechanisms (rabbits) 
R23HL-21208-02 Structure-function relationships of human 

factor VIII 
ROlHL-21294-02 Voltage clamp of isolated cardiac 

Purkinje cells (dogs) 
ROlHL-21312-01 Sarcomere mechanics in disrupted 

ventricular muscle (guinea pigs) 
ROlHL-21329-02 Beta-receptor regulation and cardiac 

sites of drug action (cat. guinea pig. rat) 
ROlHL-21371-02 Energy loss microanalysis of myocardial 

cations 
R23HL-21488-01 Myosin-linked regulation in vertebrate 

smooth muscle (calf aorta) 
ROlHL-21493-02 Contractility in cardiac failure (hamsters) 
ROlHL-21543-02 Structure-function relation of blood 

clotting proteins (rabbits) 
ROlHL-21820-01 Regulatory role of myosin in cardiac 

hypertrophy (dogs) 
ROlHL-21860-18 Factors influencing responses to 
adrenergic drugs (guinea pigs. rats, cats) 

(contd) 



M Grant has subprojects describing specific research aspects. 
See Appendix for Investigators name and grant number. 



*MM^jUMmaatlrimyt^j 



CAL 



The spontaneously hypertensive kidney 



ROIHI 21922 01 Trinjitnt cumnts Inductd by 

ilrvphanthidin m lh( hatil 
NOIHL 2I9/S 01 SludKS on normal ind abnotmal lacloi 

IX (human, dois. cows) 
ROIHL 2198801 Biochamistty ol human plalalet 

chtmotKis 
** ROIHI'2200801 Lett ventrivular calcium content and 

contractility (rati) 
ROIHI. 22039 02 Ion transport {n cardiac muscle (do|s. 

rodants, cattle) 
ROIHL 22088 02 Metabolic basis tor diabetic 

microangiopathy (cattle) 
** ROIHL 22137 02 Structure (unction pathology ot isolated 

heart cells (mice, rats) 
** ROIHL 22177 02 Mechanisms ot control ot pulmonary 

smooth muscle (dogs) 
ROIHL 22194 02 Allosteric function ol platelet contractile 

proteins (human) 
ROlHL-22216'02 Vascular mechanisms in renal 

hypertension (dogs) 
ROIHL'22281 01 Microprobe analysis and metabolite 

levels ot ischemic mycardium (dogs) 
ROIHL 2236101 Regulation of cardiac adaptation to 

exercise (rats) 
ROIHL'22401-01 Regulation ot tension and active state in 

the heart 
R01HL22426-01 Initiation ot the heartbeat-A voltage 

clamp study (bullfrogs, rabbits) 
ROIHL 22461 01 Cardiac tropomyosin and tropomyosin- 

action interactions (rabbit) 
R01HL-22500-01 Conversion of choline to 

phosphatidylcholine in lung (rabbits, pigs) 
ROlHL-22505-01 Molecular pathology of fibrinogen and 

factor XIII (human, animals) 
R01HL-22560-02 Stnjcture and motion of cilia 

(Tetrahymena, mussels) 
** POlHL-2261901 0005 Cellular mechanisms of heart 

failure - Molecular mechanism of regulation of cardiac 

muscle contraction (cattle) 
** POlHL-22619-01 0006 Cellular mechanisms of heart 

failure - Phosphorylation of contractile proteins in cardiac 

muscle contraction (dogs, rabb 
POlHL-22619-01 0008 Cellular mechanisms of heart 

failure - Molecular mechanisms and differential contractile 

responsiveness in VSM (dogs) 
ROlHL-2277101 Thrombogenic phospholipid surfaces 

(cattle) 
** ROlHL-2283601 

(rats) 
ROlHL-22868-01 Presynaptic regulatory mechanisms in 

hypertension (rats, dogs) 
R01HL-22955-0I inetics of prothrombin activation 
R23HL-22959-01 Heart development in inherited 

cardiomyopathy (hamsters) 
R01HL-229850I Properties and assembly of Z-disk 

proteins (human, other species) 
ROlHL-23010-01 Control and mechanism of platelet 

aggregation (human) 
ROlHL-23206-01 Repetitive exercise and cardiac 

enlargement (dogs) 
ROlHL-2339201 Membrane binding and transport of 

calcium and potassium ionophores 
ROlHL-23593-fll Mast cell granules -Structure and 

secretion (rats) 
ROlHL-23614-02 Pharmacology of relaxation in smooth 

muscle (mollusks) 
ROlHL-23615-01 Biochemistry of contractile proteins 

(chicken, rabbit) 
ROlHL-2399001 Role of phosphoprotein in cardiac 

inotropic responses 
ROlHL-23994-01 Biochemical properties ot human cardiac 

myosin 

CALCIUM (MINERAL) BALANCE (METABOLISM) 

ROlHL-04512-19 Ultrastructural studies of capillary 

permeability (rats, mice) 
R01HL10018-11 Effect of aging on beating heart cells in 

culture (rats) 
** R01HL1218609 Calcium transients in striated muscle 

and other cells (mammals, frogs) 
R01HL1330209 Uptake and metabolism of lipids by the 

liver (rats) 
** R01HL13870-09 Control of myocardial sarcotubular 

calcium stores (dogs) 
P50HL14147-08 0014 Specialized center of research in 

thrombosis ■ Theoretical models tor electrostatic effects in 

blood clot formation 
P50HL-14217-08 0057 Specialized center of research in 

thrombosis Pharmacology-Platelet biochemistry (human, 

animal) 
P01HL14388-07 0167 Regulation of the circulation in 

pathological states - Increased reactivity of artery vascular 

muscle in spontaneously hypertensive rat 
POlHL-14388-07 0172 Regulation of the circulation in 

pathological states - cAMP-dependent protein kinase from 

heart and vascular smooth muscle (guinea pigs) 
ROIHL- 14820-0 7 Factors affecting physiology of biological 

membranes (human) 
P60HL-15157-07 0009 Comprehensive center for sickle 

cell disease - Red cell membrane alterations during 

sickling (human) 



77 

P60HL 15169 OS 0018 Support tor cento lor sickle cell 

disease Studies on sickle cell disease (human, rati, 
dogs) 
" P60HL 1599905 0014 Miami comprehensive sickle cell 

center Biochemical and morphological parameters of 
sickle cells (human) 
" ROIHI 16003 08 Sources and roles ol cdclum In smooth 
muscle eiiitation (rats) 
ROIHL 16/14 05 Fndolholial cell communication in 

homeostasis (human, mammals) 
P60HI 17265 04 0003 Community blood resource center 

support Research Human (actor IX Role in intrinsic 
clotting (also baboons, dogs) 
P60HL 17269 04 0007 National heart and blood vessel 

research and demonstration center Correlative studies of 
experimental myocardial ischemia (dog) 
•• P60HL 17269 04 0019 National heart and blood vessel 

research and demonstration center Sarcoplasmic 
reticulum (dog. rabbit, hamster, cat) 
ROIHL 17597 05 Role of plasma lipoproteins in 

atherosclerosis (swine, human) 
P50HI 1764804 0023 Study of ischemic heart disease ■ 

Chemical mediators of inflammation in acute myocardial 
infarction (mammals) 
P50HL 17669 04 0006 Ischemic heart disease center 
(SCOR) Studies of hypoxic, acidotic and ischemic cardiac 
muscle (dogs) 
P50HL 17669 04 0022 Ischemic heart disease center 

(SCOR) Pathological studies of human and experimental 
ischemic heart disease 
P50HL 17670-04 0022 Study of ischemic heart disease - 
Myocardial metabolism in hypoxia and recover (rabbit, 
toad, dog) 
P50HL-17682-04 0012 Study of ischemic heart disease ■ 

Pathology core laboratory (human) 
P50HL 17682-04 0024 Study of ischemic heart disease - 
Phosphorylation of cardiac contractile proteins during 
ischemia (rat, guinea pig) 
** ROlHL-18077-04 Smooth muscle cell organization and 
Ca20 concentration control (chickens) 
ROlHL-18824-03 Mechanisms of heart failure in 

myopathic hamster 
ROIHL 19000-03 Irreversible myocardial injury (rats) 
ROlHL-19394-03 Biochemistry and regulation of taurine in 

the heart (rats, guinea pigs, cats) 
ROlHL-19399-02 Atherosclerosis -Early events and 

regression factors (rats) 
ROlHL-19633-02 Pathogenesis and pharmacology of lung 

fibrosis (rats, rabbits) 
ROlHL-20426-03 

(dog. rat) 
ROlHL-20558-02 

and drugs 
ROlHL-207 54-02 

(rabbits) 
ROlHL-21014-01 
cardiac glycosides 
** R23HL-212 13-01 A model for calcium homeostasis in 
excitable tissue (marine worms) 
R23HL-214 13-02 Structure and function of platelet 
calcium-binding protein (human) 
" R01HL-21670-0I Antiarrhythmic studies on 2-substifuted 

aminoindenes (dogs) 
** ROlHL-22135-01 Control of calcium fluxes across cardiac 

membranes (dogs, rabbits, guinea pigs) 
** ROlHL-22231-02 Modulation of calcium control of cardiac 
myofibrils (rats) 
ROlHL-22555-01 Structure and function of platelet 

activating factor (rabbits, human) 
R23HL-22575-01 Factors modifying cardiac digoxin effects 

and content (dogs, cats) 
R23HL-22984-01 Cyclic AMP dependent protein kinases in 

hypertension (rat) 
ROlHL-23138-01 Myocardial ischemia (dogs. rats, chick 
embryo) 
♦* ROlHL-231 53-01 Mechanisms of altered CA20 transport in 
ischemic heart (dog. rabbit) 
ROlHL-23161-01 0003 Biology of myocardial ischemia - 
Phosphorylase coupling to myocardial sarcoplasmic 
reticulum (dog) 
R01HL-23249-0I Actin-myosin interaction in pulmonary 
smooth muscle (cattle) 

CALCIUM (MINERAL) BALANCE, CALCIFICATION 
PHYSIOLOGIC 

POlHL-10436-13 0008 A multidisciplinary study of 

congenital heart disease - Physiologic consequences of 
chronic hypoxemia (human) 
" POlHL-11310-12 0101 Mechanisms of cardiovascular 

disease - Molecular pathogenesis of vascular disease 

CALCIUM (MINERAL) BALANCE, PHOSPHORUS 
BALANCE (METABOLISM) 

ROlHL-10503-13 Cardiac ion transport and ultrastructure 
(rats, guinea pigs, rabbits) 

CALCIUM (MINERAL) IMBALANCES, 
CALCIFICATION PATHOLOGIC 

** POlHL-11310-12 0101 Mechanisms of cardiovascular 

disease - Molecular pathogenesis of vascular disease 
ROlHL-15965-06 Experimental atherosclerosis and elastin 
metabolism (chicks) 



Myocardial function in diabetes mellitus 
Cardiac electrophysiology-Effects of ions 
Anesthetic-induced myocardial depression 
Mechanism of the inotropic action of 



'Excludes nwtine methodokigy OR covers only general projects which preclude indexing 
"Onented signiflcantty to above subject. 



at the specific level. 



M Grant has subprojects descnbing specific research aspects. 
See Appendix for investigator's name and grant number. 



CAP 

** ROIHL 20764 02 Flaslin and calcilicalion in pulmonary 
and vascular disease (human, mammals) 

CALCIUM (MINERAL) IMBALANCES, 
HYPERCALCEMIA 

ROIHI 00J40 29 lleclrolyte dislurbanci in cardio renal 

disease (human, dogs, rats) 
ROIHI 1660(05 Human and experimental renal diseaui 

(animal'.) 
ROIHI 22506 01 Hemodynamir.s of the clinical 
hypertensions 

CALCIUM (MINERAL) IMBALANCES, 
PHOSPHORUS IMBALANCE 

Stf Also MflABOIIC DISOROfRS INBORN. 
HYPOPHOSPHAIASIA 
ROIHL 00340 29 Lleclrolyte disturbance in cardio renal 
disease (human, dogs, rats) 

CALCIUM PUMP 

SEE BIOLOGICAI TRANSPORT. ACTIVE TRANSPORT, ION 
PUMPS, CALCIUM PUMP 

CALCULI 

SEE BILIARY TRACT DISORDERS, CHOLELITHS 
CALF 

SEE MAMMALS, ARTICDACTYU, CATTLE* 
CAUITHRIX 

SEE MAMMALS, PRIMATES, MONKEYS AND APES 

(ANTHROPOIDS. NON-HUMAN), NEW V^ORLD MONKEYS 
(PLATYRHINES)* 

CALORIC CONTENT (OF FOODS) 

SEE NUTRITION. DIETARY CONSTITUENTS. CALORIC CONTENT 
CALORIC STIMULATION 

SEE TEMPERATURE. HEAT. CALORIC STIMULATION 
CALORIMETRY 

SEE TEMPERATURE. HEAT, CALORIMETRY* 

CAMERAS, SCINTILLATION 

SEE RADIOASSAY, SCINTILLATION CAMERAS* 
CANADA 

SEE GEOGRAPHICAL SITES, N AMERICA. CANADA 
CANCER 

SEE NEOPLASMS 
CANCER CELLS 

SEE NEOPUSTIC CELLS 

CANCER CHEMOTHERAPY 

SEE NEOPLASTIC THERAPY, CANCER CHEMOTHERAPY 
CANCER COMPLICATIONS, INFECTIONS 

SEE NEOPUSMS. CANCER COMPLICATIONS OF. INFECTIONS 
CANCER DIAGNOSIS 

SEE NEOPLASMS DIAGNOSIS 
CANCER EPIDEMIOLOGY 

SEE NEOPLASTIC DISEASE EPIDEMIOLOGY-STATISTICS 
CANCER GENETICS 

SEE NEOPUSMS GENETICS 
CANCER PATIENT CARE 

SEE HEALTH CARE SERVICES. CASE FINDING AND OUTREACH 
CANCER PATIENTS, DISEASE COMPLICATIONS 

SEE NEOPLASMS, CANCER COMPLICATIONS OF 
CANCER RADIOTHERAPY 

SEE NEOPLASTIC THERAPY, CANCER RADIOTHERAPY 
CANCER SURGERY 

SEE NEOPUSMS SURGERY 
CANCER SURVIVAL RATES 

SEE NEOPUSTIC DISEASE EPIDEMIOLOGY-STATISTICS 
CANNABIS 

SEE ALKALOIDS, CANNABIS 
CANNULATION 

SEE ALSO CATHETERIZATION 
** POlHL-06312-17 0042 Surgical cardiology - Right 

ventricular assist device (sheep) 

CAPILLARIES 

SEE CARDIOVASCUUR SYSTEM, CAPILURIES 
CAPILLARY BEDS 

SEE CARDIOVASCUUR SYSTEM, CAPILURY BEDS 
CAPRIDS 

SEE MAMMALS. ARTIODACTYU. GOATS* 
CAPSID AND CAPSOMERE, VIRAL 

SEE VIRUS COMPONENTS. CAPSID AND ENVELOPE 
CAPSULES 

SEE DOSAGE FORMS 

(contd) 



CAR 

CAPUCHINS 

SEE MAMMALS, PRIMATES, MONKEYS AND APES 

(ANTHROPOIDS, NON-HUMAN), NEW WORLD MONKEYS 
(PLATYRHINES)* 

CARBACHOL 

SEE CHOLINE. CARBACHOL 

CARBAMAMIDINE 

SEE GUANIDINES 

CARBAMATES 

SEE ALSO PHENYUMINES, NEOSTIGMINE 
POlHL-20993-02 0005 Population dynamics of arterial 
cells in atherogenesis ■ Drugs ottier than hypolipidemic 
drugs aflccting atherosclerosis (swine, rabbits) 

CARBAMATES, URETHAN 

P01HL-1373707 0002 Assisted circulation - U-shaped 

mechanical auxiliary ventricle (dogs) 
NOlHV'32959-10 Development of materials for heart assist 
devices 
CARBAMIDINE 

SEE GUANIDINES 
CARBAMOYlPHOSPHATEd-ASPARTATE 
TRANSCARBAMYLASE 
SEE TRANSCARBAMYLASES, ASPARTATE TRANSCARBAMYLASE 

N-CARBAMYL AMINO ACIDS 

SEE AMINO ACIDS, N-CARBAMYL AMINO ACIDS 

CARBAMYL PHOSPHATE 

N01HB-22919-08 Hemoglobin carbamylation in the 

treatment of sickle cell anemia (human, dogs) 
ROIHL 11822-10 Biophysical studies of macromolecular 

interactions (microorganism, human) 
** P60HL-15 169-05 0018 Support for center for siclde cell 

disease - Studies on sickle cell disease (human, rats, 

dogs) 
R01HL-16375-04 Investigation of hemoglobin S properties 

(human) 
P01HL-16833-04 0009 Hemoglobin and red cell system in 

hemoglobinopathies ■ Rheological studies of sicklcd cells 

(human) 
POlHL-1683304 0014 Hemoglobin and red cell system in 

hemoglobinopathies - Erythrocyte membrane damage in Hb 

SS disease (human) 
CARBAMYLTRANSFERASES 

SEE TRANSCARBAMYUSES 

CARBOHYDRASES 

SEE ALSO N-GLYCOSYLHYDROLASES 
ROlHL-15474-06 Structure and function of the 
antihemophilic factor (human, cattle) 
** ROlHL-1788115 Biosynthesis and degradation of blood 
group substances (human, animals) 
R01HL-20301-02 Genetics of glycosyltransferases in 

human blood 
R23HL-21411-02 Control of extracellular lysosomal 
hydrolase levels (rats) 

CARBOHYDRASES, N- 

ACETYLGLUCOSAMINIDASES 

R01HL1815704 Subcellular events in atherosclerosis 

(human, rabbits, calves) 
ROlHL-20301-02 Genetics of glycosyltransferases in 

human blood 
ROlHL-20533-09 Pathogenesis of rheumatic fever (human, 
rabbits) 
CARBOHYDRASES, ALPHA-AMYLASE 

N01HR-72921-01 Cystic fibrosis factor identification and 
quantification (human) 
CARBOHYDRASES, BETA-GALACTOSIDASE 
P50HL-14153 07 0004 Johns Hopkins Lung Center- 

Chronic diseases of airways Macrophage enzymes in lung 
injury, inflammation and repair (rabbit) 
R01HL18157-04 Subcellular events in atherosclerosis 

(human, rabbits, calves) 
R01HL18723-03 Genetic heterogeneity of acid lipase - 

Atherosclerosis (human) 
ROlHL-20104-03 Pulmonary granulomatous inflammations 
(mice) 
CARBOHYDRASES, ALPHA-GIUCOSIDASE 
ROlHL-181 57-04 Subcellular events in atherosclerosis 
(human, rabbits, calves) 
CARBOHYDRASES, BETA-GLUCURONIDASE 
R01HL13885-08 0008 Cystic fibrosis and pulmonary 
disease - Pseudomonas specific activation of alveolar 
macrophages (human, rabbits) 
R01HL1907203 Modification of tissue injury in 

myocardial infarction (dogs, human) 
ROlHL-20104-03 Pulmonary granulomatous inflammations 
(mice) 
CARBOHYDRASES, HEXOSAMINIDASES 

ROIHL 13722-08 Acid and alkaline lipases in aortas (rats, 

rabbits, human) 
R01HL19721-03 Lung inflammation -Lysosomal proteases 
and liposomes (human, rabbits) 



78 

CARBOHYDRASES, HYALURONIDASE 

POlHL-06370-17 0014 Cardiopulmonary and renal 
pathology research center - Quantitative morphology In 
cardiac disease (human, rats, dogs) 
POlHL-14388-07 0219 Regulation of the circulation in 
pathological states - Myocardial ischemia and infarction in 
animals (dogs) 
POlHL-14388-07 0221 Regulation of the circulation in 
pathological states - Experimental myocardial infarction 
(dogs) 
P01HL1583206 0005 Chemical-structural predispositions 
to lung injury - Pulmonary structure and stress-strain 
relationships (rats) 
P50HL-17669-04 0012 Ischemic heart disease center 

(SCOR) ■ Circulatory assistance (human, dog) 
ROlHL-19370-03 Coronary capillary exchange-The effects 

of ischemia (dogs, sheep) 
ROlHL-19782-02 Pharmacologic studies on the ischemic 

heart (dogs) 
ROlHL-20 199-02 Drug-induced alterations in infarct size 

in the rat 
ROlHL-21282-01 Dynamics of interstitial space in whole 

animals (rats) 
ROlHL-21684-02 0002 Radionuclide Infarct sizing and 
therapy evaluation - Evaluating myocardial imaging agents 
in global and regional ischemia (rabbits) 
** ROlHL-22227-01 A new source of hyaluronidase and 

anticoagulants (leeches) 
CARBOHYDRASES, LYSOZYME 

POlHL-082 14-15 0023 Chemical and biological properties 
of lipids - Lipids in microorganisms and cell cultures 
(hamsters, mosquitoes) 
P50HL14 153-07 0004 Johns Hopkins Lung Center - 
Chronic diseases of airways - Macrophage enzymes in lung 
injury, inflammation and repair (rabbit) 
POlHL-16748-05 0006 Cellular and immunological basis 
of pulmonary diseases - Sarcoidosis -Studies with bronchial 
lavage (human) 
ROlHL-17895-04 Myocardial function and metabolism 

following ischemia (rats) 
ROlHL-18087-03 Development and regression of cardiac 

hypertrophy (rats, rabbits) 
ROlHL-18625-03 Organization of arterial ground substance 

(cattle) 
ROlHL-19237-03 Obstructive lung disease and alveolar 

macrophages (human, animals) 
ROlHL-20104-03 Pulmonary granulomatous inflammations 

(mice) 
POlHL-226 19-01 0007 Cellular mechanisms of heart 
failure - Regulation of contractile protein levels in heart 
muscle (rats) 
ROlHL-23586-06 Pharmacologic control of hypersensitivity 
phenomena (human) 
CARBOHYDRASES, NEURAMINIDASE 
POlHL-11351-12 0004 Cellular and molecular 
mechanisms of myocardial function • Molecular 
mechanisms of contractile function and differentiation 
(animals) 
POlHL-16851-04 0008 Human red cell membrane in 
health and disease - Force balance in red cell interactions 
(human) 
POlHL-17382-05 0003 Chemical mediators of acute 
pulmonary disorders - Chemical mediators relevant to 
allergic reactions (human, guinea pigs) 
ROlHL-19278-03 Ristocetin induced platelet aggregation 

(human) 
ROlHL-20533-09 Pathogenesis of rheumatic fever (human, 

rabbits) 
ROlHL-22738-01 Role of bioelectric potentials in platelet 
adherence (bats, rats, hamsters) 
CARBOHYDRATE BALANCE 

SEE ALSO CARBOHYDRATES METABOLISM DISORDERS 
** P01HL-08682 15 0020 Regulation of the cardiovascular 
system - Hepatic metabolic basis of shock (rat) 
POlHL-08682-15 0021 Regulation of the cardiovascular 

system - Hypoglycemia in pathogenesis of shock (dog) 
ROlHL-13630-08 Control of glycogen synthesis in heart 

(cattle) 
ROlHL-18923-02 Steroid-induced hyperlipidemia and 
hypertension (human, rats) 
CARBOHYDRATE BALANCE, BLOOD SUGAR 
POlHL-0868215 0019 Regulation of the cardiovascular 
system - Hepatic immunophysiology and host-defense in 
shock (rat, dog, human) 
POlHL-0868215 0020 Regulation of the cardiovascular 
system - Hepatic metabolic basis of shock (rat) 
** POlHL-08682-15 0021 Regulation of the cardiovascular 
system - Hypoglycemia in pathogenesis of shock (dog) 
P50HL-14141-05 0008 SCOR for atherosclerosis in 

childhood - Core laboratory 
ROlHL-16774-04 Genetic epidemiology of hyperlipemia 

(Honolulu) 
R01HL17479-04 Blood storage-The production of 

cardiotoxic material (dogs, human, swine) 
ROlHL-20393-03 Postsynthetic modifications of 

hemoglobin in diabetics (human) 
ROlHL-20447-03 Connective tissue and diabetic vascular 
disease (human) 



CAR 

ROlHL-20483-03 Sterol balance and cholesterol absorption 

in diabetics (human) 
R01HL-20488-03 Cholesterol metabolism in diabetic man 
R01HL-20508-03 Diabetes, hyperglycemia and 

cardiovascular disease (human) 
ROlHL-20522-03 Peripheral arterial disease in the diabetic 

(human) 
ROlHL-20539-03 Blood glucose, hemoglobin Ale. and 
diabetic vascular disease (human) 
CARBOHYDRATE BALANCE, GLUCOSE 

TOLERANCE 
** POlHL-06285-18 0151 Cardiovascular-respiratory 

physiology and biochemistry - Microangiopathy in diabetic 
and glucose intolerant children 
** P50HL-14 138-05 0008 Center for research on 

atherosclerosis - Core lipid laboratory (human) 
P50HL-14138-05 0014 Center for research on 

atherosclerosis • Core biostatistics laboratory 
P50HL-14164-07 0041 A/S SCOR -Comparative and 

experimental atherosclerosis - Nonhuman primate pediatric 
atherosclerosis risk factor 
P50HL-14236-05 0006 Prevention of premature 
arteriosclerosis • Carbohydrate metabolism and 
hypertriglyceridemia (human) 
ROlHL-19175-03 Pituitary modulation of micro-and macro- 
vascular disease (human, rats) 
P50HL-19362-02 0013 A/S SCOR-Atherosclerosis in 
nonhuman primates - Core laboratory-Lipid biochemistry 
(baboons) 
ROlHL-20418-03 Serum cholesterol binding reserve in 

diabetes (human) 
ROlHL-20508-03 Diabetes, hyperglycemia and 

cardiovascular disease (human) 
ROlHL-20535-02 Cardiovascular disease and evolving 

diabetes mellitus (human) 
ROlHL-20645-01 Etiology of myocardial infaction (human) 
** ROlHL-21010-02 Glycemia, other traits and CV death in 
40,000 persons 
ROlHL-21416-02 Atherosclerosis in new modles of 
diabetes mellitus 
CARBOHYDRATE BALANCE, HYPERGLYCEMIA 
SEE ALSO CARBOHYDRATES METABOLISM DISORDERS, 

DIABETES 
R01HL-00340-29 Electrolyte disturbance in cardio-renai 

disease (human, dogs, rats) 
P01HL06285-18 0149 Cardiovascular-respiratory 
physiology and biochemistry - Microangiopathy in 
prediabetic and diabetic subjects (human) 
** POlHL-0628518 0150 Cardiovascular-respiratory 

physiology and biochemistry - Basement membrane width 
in non-diabetic hyperglycemia 
ROlHL-09914-13 The myocardium in diabetes mellitus 

(dogs, monkeys) 
ROlHL-20381-03 Long-term study of diabetic vascular 

disease (human) 
ROlHL-20426-03 Myocardial function in diabetes mellitus 

(dog, rat) 
ROlHL-20460-03 Aortic histamine synthesis in diabetes 

(rat) 
ROlHL-20483-03 Sterol balance and cholesterol absorption 
in diabetics (human) 
** ROlHL-20508-03 Diabetes, hyperglycemia and 

cardiovascular disease (human) 
** RClHL-20539-03 Blood glucose, hemoglobin Ale, and 

diabetic vascular disease (human) 
" ROlHL-21010-02 Glycemia. other traits and CV death in 
40.000 persons 
ROlHL-21416-02 Atherosclerosis in new modles of 
diabetes mellitus 
CARBOHYDRATE BALANCE, HYPOGLYCEMIA 
SEE ALSO PANCREATIC ISLETS DISORDERS. 
HYPERINSULINISM 
POlHL-08682-15 0020 Regulation of the cardiovascular 
system - Hepatic metabolic basis of shock (rat) 
** POlHL-08682-15 0021 Regulation of the cardiovascular 
system - Hypoglycemia in pathogenesis of shock (dog) 

CARBOHYDRATE BALANCE, HYPOGLYCEMIC 
AGENTS 

SEE ALSO PANCREAS HORMONES 

ROlHL-18175-03 Drug taking for hypertension in a rural 
community 
CARBOHYDRATES 
SEE ALSO GLYCOLIPIDS 
SEE ALSO GLYCOPROTEINS 
SEE ALSO NUCLEIC ACIDS 
SEE ALSO NUCLEOSIDES 
SEE ALSO NUCLEOTIDES 
SEE ALSO NUTRITION, DIETARY CONSTITUENTS. DIETARY 

CARBOHYDRATES 
SEE ALSO OLIGOSACCHARIDES 
SEE ALSO POLYSACCHARIDES 
** ROlHL-02942-22 Biochemistry of cardiovascular connecth/e 
tissue (human, cattle, primates) 
POlHL-08214-15 0047 Chemical and biological properties 
of lipids ■ High resolution liquid chromatography for the 
analysis of biological substances 
ROlHL-11511-10 Structure of ferritin and its role in iron 
metabolism (horse, rats, human) 

(contd) 



•Excludes routine methodotogy OR covers only general projects which preclude 
"Oriented signif icantly to above subject. 



indexing at the specific level. 



M Grant has subprojects describing specific research aspects. 
See Appendix for Investigator's name and grant number. 



LJV^'ifuuuEnciCoC* . 



CAR 



79 



ROIHL lj;37 09 Erythrocytii dunni early dcvilopmanl 

(huinin, inlmtls) 
PiOHl 14164 07 0040 A/S SCOR Compiratlva and 
axparimtntal atharojclaiojii Coia angiochamistry 
laboratoiy 

SItuctute and tunclion of human plaimin 

Antihamophilic factor (human) 

Human dopamine beta hydroiylast (ilso 



Conliol ot glycoien synlheiii in heart 



Characteriiation of heart valve collagen 



ROIHI 1SS3506 
ROIHI. 168/2 04 
ROIHL 1809S 04 

cattle) 
ROIHL 1859303 

(human, pig) 
ROIHL 194S6 03 Immunoglobulins associated with serum 

hyperviscosity (human) 
ROIHL'20092 02 Structural and biological properties ol 

fibrinogen (human, rabbits) 
R23HL 21393 01 Cardiac adaptation to aging and stress 

(rats) 
ROIHL 23618 01 Substrate metabolism In isolated 

myocytes in shock (dogs. rats, guinea pigs) 

CARBOHYDRATES, AMINO SUGARS 

SEE ALSO SUGAR ACIDS. SIALIC ACIDS 
** ROIHL 17796 04 Importance ot aminosugars in digitalis 
activity (cats, rabbits) 
ROIHL 1859303 Characterijation of heart valve collagen 
(human, pig) 

CARBOHYDRATES, GLYCOSIDES 

SEE ALSO PUf«TS EXTRACTS, MEDICINAL PUNTS 
SEE ALSO STEROIDS GLYCOSIDES 
SEE ALSO TERPENES SAPONINS 
R01HL0750213 Phytochemistry of the genus thalictrum 

(dogs, plants) 
ROIHL 14775 08 Mechanisms of drug action in vascular 
smooth muscle (dog. rabbits) 

CARBOHYDRATES, MONOSACCHARIDES 

SEE ALSO HEXOSES 
ROIHL- 18028-03 Absorption ot nonvolatile compounds 

from the lung 
R01HL-2I763-09 Heparin and heparan sulfate-Structure 

and activity (beef, hog) 

CARBOHYDRATES, PROTEIN BOUND 
CARBOHYDRATES 

SEE ALSO GLYCOPROTEINS 
** ROlHL-02942-22 Biochemistry of cardiovascular connective 

tissue (human, cattle, primates) 
POlHL-11310-12 0099 Mechanisms of cardiovascular 

disease - Carbohydrate chemistry of thy-1 and related 

synaptosomal proteins 
POlHL-1 1310-12 0103 Mechanisms of cardiovascular 

disease - Heparin-Metabolism and function 
POlHL-11310-12 0104 Mechanisms of cardiovascular 

disease • Structure of connective tissue proteoglycans 

(rabbits) 
POlHL-1 1310-12 0105 Mechanisms of cardiovascular 

disease - Biosynthesis of mammalian glycoproteins 

(rabbits) 
ROlHL-14844-06 Mucous glycoprotein in human respiratory 

epithelium (also wheat) 
ROlHL-14865-07 Biochemical studies on the pathogenesis 

of emphysema (human, rats) 
ROIHL- 156 15-06 Strocture-function studies of human 

factor VIII/vWF 
** ROlHL-15728-06 The carbohydrate of the blood-clotting 

glycoproteins (mammals) 
ROlHL-17194-03 Comparison of two inherited forms of 

alpha-1-antitrypsin (human) 
" ROIHL- 17783-04 Complex carbohydrates-Structure, 

function, synthesis (swine) 
R01HL-17898-03 Cell membranes and plasma lipoproteins 



(human, swine) 
R23HL-21369-02 

bronchitis (rats) 
ROlHL-21394-02 

(rabbits) 
R01HL-21626-0I 



Tracheal mucin synthesis in experimental 
Pulmonary angiotensin-converting enzyme 



Proteoglycans of animal lung 

parenchyma (cattle, pigs, rabbits) 
ROlHL-21649-01 Biochemistry of lung proteoglycans 

(mammals) 
ROIHL-2323301 Pulmonary artery intermediate filament 

structure (cattle) 

CARBOHYDRATES, SULFOSUGARS 

SEE ALSO POLYSACCHARIDES. SULFOPOLYSACCHARIDES 
ROlHL-14844-06 Mucous glycoprotein in human respiratory 
epithelium (also wheat) 

CARBOHYDRATES, SULFOSUGARS, THIOSUGARS 

ROlHL-21763-09 Heparin and heparan sulfate-Structure 
and activity (beef, hog) 

CARBOHYDRATES BIOSYNTHESIS 

SEE ALSO HEXOSES. GLUCOGENESIS 
POlHL-1 1310-12 0103 Mechanisms of cardiovascular 

disease - Heparin-Metabolism and function 
POlHL-11310-12 0104 Mechanisms of cardiovascular 

disease - Structure of connective tissue proteoglycans 

(rabbits) 
•• POlHL-11310-12 0105 Mechanisms of cardiovascular 

disease - Biosynthesis of mammalian glycoproteins 

(rabbits) 



*• ROIHL 1363008 

(cattle) 
•• P50HI 14236 05 0006 Prevention ol premature 

arteriosclerosis Carbohydrate metabolism and 

hypertriglyceridemia (human) 
ROIHI 15728 06 The carbohydrate of the blood cloltlni 

glycoproteins (mammals) 
ROIHL 17783 04 Complex carbohydrates Structure, 

function, synthesis (swine) 
ROIHI 1/995 04 Cellular synthesis and release of 

mucopolysaccharides (rabbits) 
ROIHL 19/52 03 Phospholipid synthesis by fetal lung in 

organ culture (rats) 
ROIHL 20868 02 Regulation of glycoprotein biosynthesis in 

lung (swine) 
R23HL 22818 01 Biosynthesis of human respiratory 

mucous ghrcoprotein (also dog) 
R01HL23161 01 0003 Biology of myocardial ischemia - 

Phosphorylase coupling to myocardial sarcoplasmic 

reticulum (dog) 

CARBOHYDRATES BIOSYNTHESIS, 
GLYCONEOGENESIS 

SEE ALSO HEXOSES, GLUCONEOGENESIS 
ROIHL 15622-05 Computer simulation in cardiology (rats. 

dogs) 
ROIHL 204 76 03 Effects of diabetes on cardiac 

performance (rat) 

CARBOHYDRATES METABOLISM 

SEE ALSO CARBOHYDRATE BAUNCE 
SEE ALSO CARBOHYDRATES BIOSYNTHESIS 
ROlHL-01813 25 Regulation of metabolism by drugs and 
hormones (rats) 
" POlHL-06312-17 0046 Surgical cardiology - The 

relationship ol prostaglandins to heart disease 
ROlHL-06950-17 Red cell metabolism (human, 

vertebrates) 
POIHL 0889914 0007 Tolerance to respiratory gases in 
health and disease - Effects of high oxygen pressures on 
visual function (human, animals) 
ROlHL-10018-11 
culture (rats) 



R01HL-I2085-10 
(human, rats) 

ROlHL-12138-08 
(rats, human) 

ROlHL-12740-10 



Effect of aging on beating heart cells in 
Lipoproteincarbohydrate metabolism 
Nutritional regulation of enzyme activity 



Hypocholesterolemic agents- 
Stereochemistry (rats) 
ROlHL-1325709 Inhalation anesthesia on myocardial 

metabolism (dogs, swine, human) 
ROlHL-14526-07 Oral contraceptives and hypertension 

(rats) 
R01HL-I50 13-07 Lung oxidative metabolism and energy 

production (rodents, rabbits) 
** ROlHL-1 58 13-05 Cardiac anoxia-Protective effect of 

carbohydrate (dogs) 
ROlHL-16768-04 The sympathetic nervous system and the 

arterial wall (rabbits, pigeons) 
P50HL-17646-04 0009 Study of ischemic heart disease - 

Regional metabolic derangements indicating ischemia 

(rabbit, dog, human) 
P50HL-191 71-02 0010 Pulmonary SCOR-Lung injury by 

childhood infections - Metabolic pathways of normal and 

injured respiratory cells 
ROlHL-20408-03 Hyperlipidemia in diabetics during 

muscular training (human) 
ROlHL-20520-03 Protein modification-The key to diabetic 

sequelae (human, animal) 
ROlHL-214 16-02 Atherosclerosis in new modles of 

diabetes mellitus 

CARBOHYDRATES METABOLISM, GLUCOSE 
METABOLISM 

SEE ALSO CARBOHYDRATE BALANCE 

SEE ALSO HEXOSES, GLYCOLYSIS 

SEE ALSO TRICARBOXYLIC ACIDS, KREBS CYCLE 
POlHL-06285-18 0135 Cardiovascular-respiratory 

physiology and biochemistry - Beta-adrenergic agents and 

fetal cardiovascular dynamics (lambs) 
ROlHL-08506-15 Lipemia-carbohydrate and glyceride 

metabolism (human, rats) 
POlHL-08682-15 0020 Regulation of the cardiovascular 

system - Hepatic metabolic basis of shock (rat) 
" POlHL-1 13 10-12 0080 Mechanisms of cardiovascular 

disease - Metabolism of the hypertrophied myocardium 

(human) 
ROlHL-12740-10 Hypocholesterolemic agents- 
Stereochemistry (rats) 
ROlHL-12879-09 0008 Pulmonary transport and 

metabolism in vivo - Stop-flow technique for permeability 

measurements 
ROlHL-13405-09 Regulation of lipid metabolism in the 

lung (rats) 
ROlHL-13694-08 Capillary basement membrane in 

cardiovascular disease (human, rats) 
POlHL-13851 16 Cyclotron produced isotopes in biology 

and medicine (human, animals) 
R01HL14706-07 Fetal hearts in organ culture (mice) 
POIHL-14985-07 0011 Adaptation to hypoxia - 

Prostaglandins in the control of the pulmonary circulation 

(animals) 



•Odudes mitine raethodotogy OR covers only general projects which preclude indexing at the specific level 
Onented significantly to above subject. 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



CAR 

POIHI 14985 07 0017 Adaptilwn to hrpoaii birKi 

ellict ol hypoiK on pulmonary vttiulti >moolh muicl* 
(rati, dogs) 
P50HL 15061 0/ 0002 Ritpon-.< ol lung to iniury 

Oxidative metaboliim. phoipholipid lynlhetit. and ictpon-.« 
to toiini (rail) 
P50H1 15092 0/ 0006 Immune and fibroin letpontt to 

occupational enviionmenti Immunologic itudiai in 
silicosis (human, rabbits, hamsters, guinea pigt) 
ROIHI 1/43/03 Perfusion lung Role ol IraumatuM) 

leukocytes (dogs, human) 
P50HI 1/667 04 0012 Study ol i-.chemic heart diieau - 

Biochemistry ol normal and ischemic heart Clycolyiii (rili) 
P50HI 1/66/ 04 0040 Study of ischemic heart diM*M 

Core biochemistry Cardiac metabolism (human) 
*• ROIHL 1/895 04 Myocardial lunction and metabolism 
following ischemia (ralsl 
ROIHI 181/602 Eflnrt »( ih«.r,ifl hormone on cultured 

(aidiac cells (i.i 
P50HL 18318 03 00i3 i jii.jkciiesis and complications of 
hypertension Cultured smooth muscle cells and 
microvessel metabolism (mammals) 
POIHI 19242 02 0001 Study ol vascular smooth muscle 

Energy metabolism and protein turnover in vascular smooth 
muscle (rats) 
** ROIHL 20206 02 Carbohydrates nucleotides and adrenergic 
interactions (rabbits, cats, rats) 
ROIHL 20401-03 Relationship of insulin to catechol 

cardiomyopathy (rabbit, pig) 
ROIHL 20429 03 Study of effects of diabetes reactivity 
(miniature pigs, rats) 
"* R01HL21209-02 Alterations of metabohsm in ischemic 
myocardium (swine) 
ROIHL 22088-02 Metabolic basis for diabetic 

microangiopathy (cattle) 
ROlHL-2210102 Hormone substrate interaction in diabetic 
myocyte (dogs, rats) 

CARBOHYDRATES METABOUSM DISORDERS 

SEE ALSO CARBOHYDRATE BALANCE 

SEE ALSO METABOLIC DISORDERS INBORN. DISACCHARIDE 

(OLIGOSACCHARIDE) INTOLERANCE 
SEE ALSO METABOLIC DISORDERS INBORN. GLUCOSE-6- 
PHOSPHATE DEHYDROGENASE DEFICIENCY 
SEE ALSO METABOLIC DISORDERS INBORN. GLYCOGENOSIS 
SEE ALSO METABOLIC DISORDERS INBORN. OBESIPf 

HEREDITARY HYPERGLYCEMIC 
SEE ALSO PANCREATIC ISLETS DISORDERS 
** ROlHL-08506-15 Lipemia-carbohydrate and glyceride 
metabolism (human, rats) 
POlHL-12373-10 0006 Cardiopulmonary physiology and 

pathophysiology - Fatty acid metabolism-Regulation, 
implications (human, mammals, birds) 
** ROlHL-12399-13 Specific fatty acids and cholesterol 
metabolism (gerbils. rats) 
R01HL-18776-04 Prevention of acute and fatal 

cardiovascular disease (human) 
ROlHL-19961-03 Management of hemosiderosis in 
thalassemia (children, adults) 

CARBOHYDRATES METABOLISM DISORDERS, 
DIABETES 

SEE ALSO CARBOHYDRATE BALANCE, GLUCOSE TOLERANCE 

SEE ALSO CARBOHYDRATE BALANCE, HYPOGLYCEMIC AGENTS 

SEE ALSO CARBOHYDRATES METABOLISM DISORDERS, 
DIABETIC ANGIOPATHIES 

SEE ALSO MHABOLIC DISORDERS INBORN, OBESITY 
HEREDITARY HYPERGLYCEMIC 

SEE ALSO PANCREATIC ISLETS DISORDERS 
ROlHL-02063-23 Biochemistry and function of lipids and 

cell membranes (human, yeast, animals) 
ROlHL-02965-22 Metabolism of plasma lipoproteins (rats, 

chickens, human) 
ROlHL-04300-20 Fine structure of diseased glomeruli 

(human, rats, dogs) 
ROlHL-06221-17 Composition and structure of plasma 

lipoproteins (human, turkeys, baboons) 
" POlHL-06285-18 0149 Cardiovascular-respiratory 

physiology and biochemistry - Microangiopathy in 

prediabetic and diabetic subjects (human) 
POlHL-06285-18 0150 Cardiovascular-respiratory 

physiology and biochemistry - Basement membrane width 

in non-diabetic hyperglycemia 
POlHL-06314-17 0064 Immunologic mechanisms in 

cardiovascular disease - Diabetic vascular disease (human, 

rats, mice) 
POlHL-0631417 0066 Immunologic mechanisms in 

cardiovascular disease - Sensitization, cell-mediated 

cytotoxicity, role of lymphocytes (human, mice) 
POlHL-08214-15 0006 Chemical and biological properties 

of lipids - Analysis and properties of lipids 
R01HL-08659-I4 Myocardial performance and metabolism 

in the newborn (sheep) 
POlHL-0897414 0028 Natural and experimental 

atherosclerosis - Geographic pathology of atherosclerosis 

and coronary heart disease (human) 
ROlHL-09914-13 The myocardium in diabetes mellitus 

(dogs, monkeys) 
'♦ POlHL-11678-11 0046 Cardiovascular dynamics and their 

control - Regulation of aldosterone secretion and related 

factors (dogs) 

(coittd) 



CAR 

POlHL-12373-10 0012 Cardiopulmonary physiology and 

pathophysiology ■ Biochemistry of the sympathetic nervous 

system (rats! rabbits, pigeons) 
ROlHL-12766-09 Structure-function relation of blood 

vessels (rats, monkeys) 
** ROlHL-12869-09 Arterial metabolism, diabetes and 

atherogenesis (rats, rabbits) 
ROlHL-13036-08 Coronary thrombosis -Effects on 

myocardium and in vivo detection (dogs, monkeys) 
ROlHL-13405-09 Regulation of lipid metabolism in the 

lung (rats) 
ROlHL-13654-08 Antilipemic regimes in peripheral 

arteriosclerosis (human) 
P50HL-14138-05 0015 Center for research on 

atherosclerosis ■ Arterial wall -Intermediary metabolism, 

enzyme activity and bioenergetics 
P50HL-14236-05 0004 Prevention of premature 

arteriosclerosis - Plasma lipoproteins (human, rats) 
P50HL-14236-05 0006 Prevention of premature 

arteriosclerosis - Carbohydrate metabolism and 

hypertriglyceridemia (human) 
ROlHL-14713-06 Hypothermia and the heart (bats, guinea 

pigs) 
ROlHL-15047-06 Digital computer analysis of the 

electrocardiogram (human) 

P50HL-15103-07 0001 A/S SCOR -Early natural history of 

arteriosclerosis - Clinical research -Bogalusa heart study 

(children) 

ROlHL-15427-06 Secretion of plasma lipoproteins (rats) 

ROlHL-15622-05 Computer simulation in cardiology (rats, 

dogs) 
ROlHL-15696-06 Mechanism and role of cyclic GMP in 

heart (animals) 
ROlHL-16219-05 Mechanisms of atherogenesis in chronic 

uremia (human, rats) 
P50HL1 7667-04 0012 Study of ischemic heart disease - 

Biochemistry of normal and ischemic heart -Glycolysis (rats) 
P50HL- 183 18-03 0002 Pathogenesis and complications of 
hypertension - Core experimental animal facility (rats, 
rabbits) 
P50HL-18318-03 0014 Pathogenesis and complications of 
hypertension Arterial metabolism and atherogenesis (rat, 
rabbit) 
POlHL-18645-03 0007 Biology of the artery wall and 
atherosclerosis - Lipoprotein metabolism in subhuman 
primates 
ROlHL-18687-03 Pathophysiology of genetic 

hypertriglycerinemias (human) 
ROlHL-18705-03 Regulation of plasma triglyceride 

metabolism (rats) 
ROlHL-18938-03 Pulmonary fatty acid and phospholipid 

metabolism (rats) 
ROlHL-19175-03 Pituitary modulation of micro-and macro- 
vascular disease (human, rats) 
ROlHL-19467-03 Regulation of blood pressure (rats, dogs) 
ROlHL-19644-03 Etiological factors in hypertension 

(human, dogs, rats) 
ROlHL-19839-09 Factors in youth predisposing to chronic 
diseases (former college students) 
** ROlHL-20381-03 Long-term study of diabetic vascular 

disease (human) 
** ROlHL-20388-03 Regulation of protein turnover in diabetic 
heart (rat) 
ROlHL-20391-03 Polydisperse LDL-Structure, metabolism 
and function (human) 
** ROlHL-20393-03 Postsynthetic modifications of 

hemoglobin in diabetics (human) 
** ROlHL-20397-03 VLDL-TG metabolism in diabetes mellitis 

(human, rat) 
** ROlHL-2039903 Vascular control in experimental diabetes 

mellitus (dog) 
** ROlHL-20401-03 Relationship of insulin to catechol 

cardiomyopathy (rabbit, pig) 
** ROlHL-20408-03 Hyperlipidemia in diabetics during 

muscular training (human) 
** ROlHL-20411-03 Platelet fatty acid metabolism in 

diabetes (rat, rabbit, guinea pig) 
" ROlHL-20418-03 Serum cholesterol binding reserve in 

diabetes (human) 
** ROltlL-20426-03 Myocardial function in diabetes mellitus 
(dog, rat) 
ROlHL-20428-03 The juvenile diabetic heart (human) 
** ROIHL 20429-03 Study of effects of diabetes reactivity 

(miniature pigs, rats) 
•• ROlHL-20439-02 Effects of insulin on neurovascular 

transmission (human, rats, rabbits, hamsters) 
*• ROlHL-20446-02 Autonomic neuropathy in diabetic mice 

(also rats) 
** ROlHL-20447-03 Connective tissue and diabetic vascular 

disease (human) 
** ROlHL-20460-03 Aortic histamine synthesis in diabetes 

(rat) 
** ROlHL-20471-03 Atherosclerosis and diabetes mellitus 

(human) 
** ROlHL-204 76-03 Effects of diabetes on cardiac 

performance (rat) 
** ROIHL 20483-03 Sterol balance and cholesterol absorption 

In diabetics (human) 
•* ROlHL-20484-03 Effects of diabetes on cardiac function 

and metabolism (rats) 
** ROlHL-20488-03 Cholesterol metabolism in diabetic man 



80 

* ROlHL-20508-03 Diabetes, hyperglycemia and 

cardiovascular disease (human) 

* ROlHL-20517-03 Diabetes, somatotropin, factor VIII and 

atherosclerosis (human, animal) 

* ROlHL-20520-03 Protein modification-The key to diabetic 

sequelae (human, animal) 

* ROlHL-20522-03 Peripheral arterial disease in the diabetic 

(human) 

* ROlHL-20535 02 Cardiovascular disease and evolving 

diabetes mellitus (human) 
ROlHL-21010-02 Glycemia. other traits and CV death in 
40,000 persons 

* R23HL-21291-02 Renin-mineralocorticoid axis in 

hypertensive diabetics (human) 
R23HL-21320-02 Cyclic nucleotide metabolism in vascular 
endothelium 
'* ROIHL-214 16-02 Atherosclerosis in new modles of 

diabetes mellitus 
'* R01HL-21482-01 Cardiac function and metabolism in 

diabetes (rats) 
'* R23HL-21842-01 Control of sugar entry in normal and 

diabetic heart (rats) 
" ROlHL-21843-01 Ischemia, diabetes and the 

microcirculation (rats, cats, hamsters) 
** ROlHL-22053-02 The disordered lipid metabolism of 

diabetes mellitus (chickens, mammals, human) 
** ROlHL-22064-02 Glycogen metabolism in anoxic diabetic 

myocardium (rats) 
** ROlHL-22088-02 Metabolic basis for diabetic 

microangiopathy (cattle) 
** R01HL-22101-02 Hormone-substrate interaction in diabetic 

myocyte (dogs, rats) 
** ROlHL-221 06-02 Diabetic cerebral vascular structure and 

function 
** ROlHL-221 13-02 Micro/macrovasculature in healing of 

foot lesions (human) 
** ROlHL-221 15-02 Lipid-mobilization and diabetic 

atherosclerosis (human) 
** ROlHL-221 18-02 Microcirculation in patients with diabetes 

mellitus 
** ROlHL-22121-02 Oyslipoproteinemia in diabetes and 

vascular disease (human) 
** ROlHL-22123-02 The role of the red cell in diabetic 
atherosclerosis (human) 
ROlHL-22474-01 Cholesterol metabolism and 

atherosclerosis (rats, human, rabbits) 
ROlHL-22506-01 Hemodynamics of the clinical 
hypertensions 
** ROlHL-22581-02 Neurocirculatory control in diabetes 
mellitus (human) 
ROlHL-228 12-01 Regulation of hepatic production of HDL 

(rats) 
ROlHL-23602-01 Physiology of renin, aldosterone and 

prostaglandin (human, rats, dogs) 
ROlHL-236 18-01 Substrate metabolism in isolated 

myocytes in shock (dogs, rats, guinea pigs) 
NOlHV-121 56-10 Lipid research clinic 
NO lHV-12 159-09 Lipid research clinic 
NOlHV-229 16-16 Establishment of a lipid research clinic 

CARBOHYDRATES METABOLISM DISORDERS, 
DIABETES, INSULIN (RESISTANCE) TOLERANCE 

SEE ALSO METABOLIC DISORDERS INBORN, OBESITY 
HEREDITARY HYPERGLYCEMIC 
** POlHL-06835-17 0024 Cardiovascular disease - Studies 

on the obese spontaneously hypertensive rat 
** ROlHL-08506-15 Lipemia-carbohydrate and glyceride 
metabolism (human, rats) 
ROlHL-196 73-03 Surgical aspects of shock and hypoxia 

(dogs, monkeys, rats) 
ROlHL-221 15-02 Lipid-mobilization and diabetic 

atherosclerosis (human) 
ROlHL-22123-02 The role of the red cell in diabetic 
atherosclerosis (human) 
CARBOHYDRATES METABOLISM DISORDERS, 
DIABETES, JUVENILE 
ROlHL-02942-22 Biochemistry of cardiovascular connective 

tissue (human, cattle, primates) 
P01HL-06285-18 0151 Cardiovascular-respiratory 
physiology and biochemistry - Microangiopathy in diabetic 
and glucose intolerant children 
POlHL-09011-15 0001 A research and resource program 
in blood - Genetic markers of human blood and gene 
mapping (human) 
** ROlHL-13632-08 Vascular changes in diabetes mellitus 
(human) 
ROlHL-20401-03 Relationship of insulin to catechol 

cardiomyopathy (rabbit, pig) 
ROlHL-20408-03 Hyperlipidemia in diabetics during 

muscular training (human) 
ROlHL-204 18-03 Serum cholesterol binding reserve in 
diabetes (human) 
** ROlHL-20428-03 The juvenile diabetic heart (human) 
ROlHL-20446-02 Autonomic neuropathy in diabetic mice 

(also rats) 
ROlHL-20447-03 Connective tissue and diabetic vascular 
disease (human) 
** ROlHL-205 17-03 Diabetes, somatotropin, factor VIII and 

atherosclerosis (human, animal) 
** ROlHL-20539-03 Blood glucose, hemoglobin Ale, and 
diabetic vascular disease (human) 



CAR 

ROlHL-22123-02 The role of the red cell in diabetic 
atherosclerosis (human) 
CARBOHYDRATES METABOLISM DISORDERS, 
DIABETES, PREDIABETIC STATE 

** POlHL-06285-18 0149 Cardiovascular-respiratory 
physiology and biochemistry - Microangiopathy in 
prediabetic and diabetic subjects (human) 
ROlHL-13694-08 Capillary basement membrane in 

cardiovascular disease (human, rats) 
ROlHL-20535-02 Cardiovascular disease and evolving 
diabetes mellitus (human) 
CARBOHYDRATES METABOLISM DISORDERS, 
DIABETES IN PREGNANCY 
ROIHL 19752-03 Phospholipid synthesis by fetal lung in 

organ culture (rats) 
ROlHL-20535-02 Cardiovascular disease and evolving 
diabetes mellitus (human) 
CARBOHYDRATES METABOLISM DISORDERS, 
DIABETIC ACIDOSIS 
SEE ALSO KETONE BODIES 

ROlHL-22581-02 Neurocirculatory control in diabetes 
mellitus (human) 
CARBOHYDRATES METABOLISM DISORDERS, 
DIABETIC ANGIOPATHIES 
SEE ALSO CARBOHYDRATES METABOLISM DISORDERS, 

DIABETIC NEUROPATHIES 
SEE ALSO CARBOHYDRATES METABOLISM DISORDERS, 

DIABETIC RETINOPATHY 
ROlHL-02942-22 Biochemistry of cardiovascular connective 
tissue (human, cattle, primates) 
** POlHL-03 174-23 0007 Mechanisms of acute vascular 
reaction to injury - Healing of injured myocardium-Basal 
lamina scaffold (human, rats, dogs) 
** POlHL-06285-18 0149 Cardiovascular-respiratory 
physiology and biochemistry - Microangiopathy in 
prediabetic and diabetic subjects (human) 
POlHL-06285-18 0151 Cardiovascular-respiratory 
physiology and biochemistry ■ Microangiopathy in diabetic 
and glucose intolerant children 
** POlHL-06285-18 0152 Cardiovascular-respiratory 

physiology and biochemistry - Diabetic microangiopathy by 
organ and tissue culture (human) 
** POlHL-06314-17 0064 Immunologic mechanisms in 

cardiovascular disease - Diabetic vascular disease (human, 
rats, mice) 
ROlHL-12085-10 Lipoprotein-carbohydrate metabolism 
(human, rats) 
" ROIHL- 13632-08 Vascular changes in diabetes mellitus 

(human) 
** ROIHL- 13694-08 Capillary basement membrane in 

cardiovascular disease (human, rats) 
•* ROlHL-17932-04 Blood flow regulation in muscle (cats) 
ROlHL-18977-03 Non-invasive diagnosis of peripheral 

arterial disease (human, dogs) 
ROlHL-19175-03 Pituitary modulation of micro-and macro- 
vascular disease (human, rats) 
** ROlHL-20381-03 Long-term study of diabetic vascular 
disease (human) 
ROlHL-20393-03 Postsynthetic modifications of 
hemoglobin in diabetics (human) 
** ROlHL-20400-03 Diabetic neuropathy and peripheral 
vascular diseases (human, hamsters) 
ROlHL-20411-03 Platelet fatty acid metabolism in 

diabetes (rat, rabbit, guinea pig) 
ROlHL-20428-03 The juvenile diabetic heart (human) 
** ROlHL-20429-03 Study of effects of diabetes reactivity 
(miniature pigs, rats) 
ROlHL-20447-03 Connective tissue and diabetic vascular 
disease (human) 
** ROlHL-20500-02 Diabetic human brain microvascular 
basement membrane (human) 
ROlHL-20508-03 Diabetes, hyperglycemia and 
cardiovascular disease (human) 
** ROlHL-20517-03 Diabetes, somatotropin, factor VIII and 

atherosclerosis (human, animal) 
" ROlHL-20520-03 Protein modification-The key to diabetic 

sequelae (human, animal) 
** ROlHL-20539-03 Blood glucose, hemoglobin Ale, and 

diabetic vascular disease (human) 
** ROlHL-21039-02 Vascular lesions of diabetes in Oklahoma 
Indians 
R23HL-21320-02 Cyclic nucleotide metabolism in vascular 

endothelium 
ROlHL-21416-02 Atherosclerosis in new modles of 

diabetes mellitus 
ROlHL-21756-11 Vascular disease-Cytochemistry and 
ultrastructure (human, rats, mice, hamsters) 
** ROlHL-22064-02 Glycogen metabolism in anoxic diabetic 

myocardium (rats) 
** ROlHL-22101-02 Hormone-substrate interaction in diabetic 
myocyte (dogs, rats) 
ROlHL-22113-02 Micro/macrovasculature in healing of 
foot lesions (human) 
** R01HL-22115-02 Lipid-mobilization and diabetic 

atherosclerosis (human) 
** ROlHL-221 18-02 Microcirculation in patients with diabetes 
mellitus 
ROlHL-22123-02 The role of the red cell in diabetic 
atherosclerosis (human) 

(contd) 



•Excludes routine melhodotogy OR covers only general projects which preclude i 
'•Onented significantly to above subiect. 



ndexing at the specific level. 



M Grant has subprojeds describing specific research aspects. 
See Appendix tor investigator's name and grant number. 



CAR 

CARBOHYDRATES MITABOUSM DISORDERS, 
DIABETIC NEPHROPATHIES 

POIHI 06314 i; 00b.' Iiiimunologic inochaiiisms In 

cttdlovisculai disease Immunologic lend vasculic 

diseise Ihumeo. animals) 
ROIHL 17364 04 Big lenin' Biochemical and cllnicti 

studies (human) 
ROIHL 20381 03 Long leim study ol diabetic vasculaf 

disease (human) 
** ROIHL 2?581 02 NeurocirculatoiY contiol in diabetes 

mellilus (human) 

CARBOHYDRATES METABOLISM DISORDERS, 
DIABETIC NEUROPATHIES 

ROim ?0.'06 0? Carbohydiatps nucleotides and adienergic 

inleiaclions (labbils. cats, lats) 
•* ROlHl 2040003 Diabetic neuropathy and penpheial 

wasculai diseases (human, hamsters) 
ROIHL 20439 02 Etlects ol insulin on neurovasculai 

transmission (human, rats, labbits. hamsters) 
ROIHL 20446 02 Autonomic neuropathy in diabetic mice 

(also lats) 

CARBOHYDRATES METABOLISM DISORDERS, 
DIABETIC RETINOPATHY 

POIHL 06314 17 0064 Immunologic mechanisms in 

caidiovascular disease Diabetic vascular disease (human, 

rats, mice) 
ROIHL 1363208 Vascular changes in diabetes mellitus 

(human) 
P50HL 14236-05 0009 Prevention of premature 

arteriosclerosis ■ Clinical studies on,cholesterol metabolism 

(human) 
ROlHL-20455-03 Role of systemic hypertension on diabetic 

retinopathy (human) 
ROIHL 2208802 Metabolic basis tor diabetic 

microangiopathy (cattle) 

CARBOHYDRATES STRUCTURE 

R01HL02942-22 Biochemistry of cardiovascular connective 

tissue (human, cattle, primates) 
ROlHL-0622117 Composition and structure of plasma 

lipoproteins (human, turkeys, baboons) 
P01HL09011-15 0005 A research and resource program 
in blood - Characterization of hepatitis B antigen and the 
cause of serum hepatitis (human) 
" POlHL-1 1310-12 0099 Mechanisms of cardiovascular 

disease Carbohydrate chemistry of thy-1 and related 
synaptosomal proteins 
P01HL-1I310-12 0103 Mechanisms of cardiovascular 
disease - Heparin-Metabolism and function 
" P01HL-11310-12 0105 Mechanisms of cardiovascular 

disease - Biosynthesis of mammalian glycoproteins 
(rabbits) 
P50HL- 15389-07 0014 Pulmonaiy SCOR-Hypersensitivity 

pneumonitis - Fractionation and characterization of pigeon 
antigens 
ROlHL-1547406 Structure and function of the 

antihemophilic factor (human, cattle) 
ROlHL-16166-05 Structure of alpha-l-antitrypsin in 

relation to emphysema (human) 
R01HL-17194-03 Comparison of two inherited forms of 
alpha-I-antitrypsin (human) 
" R01HL-17783-04 Complex carbohydrates -Structure, 
function, synthesis (swine) 
R01HL-17995-04 Cellular synthesis and release of 

mucopolysaccharides (rabbits) 
ROlHL-18714-04 Cardiovascular matrix -Morphogenesis 

and maturation (human, chick embryo, mammal) 
ROlHL-19011-03 Smooth muscle cell membrane 

glycoprotein biosynthesis (cattle) 
P50HL-19190-02 0005 Pulmonary SCOR-Pafhophysiology, 

management of IRDS - Glycoproteins in mucous secretions 
(human, cattle) 
ROIHL 1982002 The chemistry and biological effects of 

heparin (Rhesus, human, other mammals) 
ROlHL-20500-02 Diabetic human brain microvascular 

basement membrane (human) 
ROlHL-20547 02 Glycoproteins in pulmonary alveolar 

proteinosis (human) 
ROlHL-20868-02 Regulation of glycoprotein biosynthesis in 

lung (swine) 
ROIHL-21615-01 Structural studies of lung heparinoid 

polysaccharides (cattle) 
ROlHL-21692-02 Purification of erythropoietin (human) 
ROlHL-21763-09 Heparin and heparan sulfate- Structure 

and activity (beef, hog) 
ROlHL-22983-01 Studies on the catabolism of plasma 
lipoproteins (rats) 

CARBOHYDRATES STRUCTURE, SUGAR 
SEQUENCE 

ROlHL-15125-07 Molecular pathology of genetic disorders 

in man 
P50HL-1 5389-07 0015 Pulmonary SCOR-Hypersensitivity 

pneumonitis - Fractionation and characterization of 

thermophilic Actinomycetc antigens 
R01HL17783-04 Complex carbohydrates-Structure. 

function, synthesis (swine) 
ROlHL-19084-03 Structure and function of serum 

lipoproteins (human) 
ROlHL-21480-01 Structure, source and functions of 

alveolar glycoproteins (human, rabbits) 



• I 

ROIHI 21612 02 Biochemlitry o( lunf proteo|lycini 

(human, rabbits) 

RO 1 HI 2 1 6 1 5 1 Structural studies ol lung heparinoid 

polysaccharides (cattle) 

ROIHL 2161/02 Biochemistry ol lung proteoglycans 

(rabbits, cattle) 

ROIHL 21686 02 Purification of erylhiopoielin (human) 

CARBOHYDRATES TRANSPORT (GENERAL) 

PDIHI 06:'8!) 18 0132 Caidiovascular lespiialoiy 

physiology and biochemistry Umbilical placental 

circulatory responses (lambs) 
ROIHL 15013 07 Lung oxidative metabolism and energy 

production (rodents, rabbits) 
POIHL 16851 04 0006 Human red cell membrane in 

health and disease Hcxose transport and erythrocyte 

membrane proteins (human) 
POIHL 19737 02 0001 Cellular and molecular aspects ol 

respiratory physiology Fatty acid metabolism in type II 

alveolar cells (rats) 
R23HL 21842 01 Control of sugar entry in normal and 

diabetic heart (rats) 

CARBOHYDRATES TRANSPORT, GLUCOSE 
TRANSPORT 

ROIHL 02835 21 Renal transport carrier for organic 

compounds (dogs, rats) 
■• P01HL08899 14 0054 Tolerance to respiratory gases m 

health and disease Glucose transport across choroid 

plexus (dogs) 
ROIHL 12879 09 0005 Pulmonary transport and 

metabolism in vivo Glucose transport by pulmonary 

endothelium and epithelium (dogs) 
ROIHL 13029-09 Metabolic regulation of sugar transport 

(pigeons, rats) 
** R01HL-M483 08 Energy conservation in heart 

mitochondria (cattle, E coli, human) 
R01HL-166I1-04 Digitalis-receptor of the heart (guinea 

pigs, rats) 
** POlHL-1685104 0006 Human red cell membrane in 

health and disease - Hexose transport and erythrocyte 

membrane proteins (human) 
ROlHL-19463-02 Pathophysiology of acute renal failure 

(rats) 
ROlHL-20605-02 Microvascular responses during intestinal 

absorption (rats) 
ROlHL-221 72-01 Hypotension, renal ischemia and effect of 

mannitol (dogs, rats) 
ROlHL-22951-01 Studies on the affect of vitamin E on 

platelets (human, rats) 

CARBON 

SEE ALSO RADIOISOTOPES. CARBON 
P01HL-06314-17 0048 Immunologic mechanisms in 

cardiovascular disease - Pathogenesis of glomerulonephritis 

(rats, mice) 
NOlHV-32919-12 Material development and testing 

heparinization processes 
N01HV-42928-07 Continued development of carbon film 

deposits for prosthetics 

CARBON 1 1 

SEE RADIOISOTOPES. CARBON 
CARBON 1 3 LABELED 

SEE ISOTOPE LABELED. STABLE CARBON 
CARBON-CARBON LIGASES 

ROlHL-16628-05 Regulation of lipid metabolism (rats) 

CARBON-CARBON LIGASES, ACETYl-COA 
CARBOXYLASE 

R01HL12399-13 Specific fatty acids and cholesterol 

metabolism (gerbils, rats) 
ROlHL-16364-04 Regulation of lipid biosynthesis and 

transport (rats, swine, Xenopus) 
ROIHL-16628-05 Regulation of lipid metabolism (rats) 
ROlHL-18938-03 Pulmonary fatty acid and phospholipid 

metabolism (rats) 
ROlHL-204 11-03 Platelet fatty acid metabolism in 

diabetes (rat, rabbit, guinea pig) 

CARBON-CARBON LIGASES, PROPIONYL COA 
CARBOXYLASE (ATP-HYDROLYZING) 

ROlHL-16628-05 Regulation of lipid metabolism (rats) 
CARBON DIOXIDE 

SEE RESPIRATORY GASES, CARBON DIOXIDE 
CARBON DIOXIDE TENSION 

SEE RESPIRATORY GAS LEVELS, CARBON DIOXIDE TENSION 
CARBON DIOXIDE TRANSPORT 

SEE RESPIRATORY GAS TRANSPORT, CARBON DIOXIDE 
TRANSPORT 

CARBON MONOXIDE 

R01HL-05556-19 Proteins, lipoproteins-Structure and 

reactivity (chicken, human, diving mammals) 
ROlHL-121 74-11 Ventilation/perfusion distribution in the 

lung (human, mammals) 
ROlHL-12524-10 Reaction of hemoglobin with ligands and 

antibodies (human, carp) 
ROlHL-131 57-09 Molecular oxygen carriers-Synthesis, 

structure, bonding 



CAR 

ROIHI I35RI II Reacliont ol oiygan with h«m« protgmt 
ROIHI 14 1 31 III Abnormal hemoglobin syndromes 

(human) 
ROIHI 15520 06 Total blood replaroment by lluorocaiboni 

and polyols (rats) 
ROIHI 15980 06 Reictions ol hemeproleint and oiyitn 

(cetlle) 
ROIHt 1668604 Properties ol cytochrome oxidase (cattle. 

bacteria) 
ROIHI 1/51703 Arterial wall oxygen trinsporl in 

atherosclerosis (rabbits, dogs) 
ROIHL 18969 02 Arterial wall oxygenation (rabbits, dogs) 
ROIHL 19299 03 Myoglobin and oxygen supply to heart 

and muscle cells (rats, pigeons) 
P50HL 1936? 02 0006 A/S SCOR Atherosclerosis in 

nonhuman primates Effects of cigarette smoking on 

atherosclerosis (baboon) 
ROIHL 1948803 Picosecond laser studies of heme 

proteins 
•• POIHL 1973702 0009 Cellular and molecular aspects ol 

respiratory physiology Regulation of tissue oxygen tension 

and body carbon monoxide stores (human, dogs) 
POIHL 19/3/ 02 001 1 Cellular and molecular aspects of 

respiratory physiology Chemical and metabolic factors on 

peripheral chemoreceplor activity (cats) 
ROIHL 19/4603 Proliferation and differentiation of 

alveolar macrophages (mice, hamsters) 
ROIHL 201/602 Biochemistry and genetics of salt 

hypertension (rats) 
ROIHL 20996-02 Structural and reactivity of iron and 

cobalt complexes 
ROlHL-22859 01 Effect of carbon monoxide on the 

developing heart (rats) 

CARBON MONOXIDE POISONING 

SEE TOXICOLOGY. GAS POISONING. CARBON MONOXIDE 
CARBON RADIOISOTOPES (11,14) 

SEE RADIOISOTOPES. CARBON 
CARBON-SULFUR LYASES, GLYOXALASE I 

R01HL-2363I 01 Immunogenetic factors in allergic 
respiratory diseases (human) 

CARBONATES 

ROlHL-20725-02 Mechanisms and cellular functions of ion 
transport 

CARBONATES, BICARBONATES 

SEE ALSO SODIUM BICARBONATE 
ROlHL-00759 29 Regulation of electrolyte and acid base 

equilibrium (dogs) 
POlHL-06285-18 0198 Cardiovascular respiratory 

physiology and biochemistry - Renal tubular secretion of 

hydrogen ion (animals) 
POlHL-06285-18 0199 Cardiovascular-respiratory 

physiology and biochemistry - Renal tubular reabsorption of 

sodium chloride (hamsters, rabbits) 
POlHL-07896-15 0029 Environmental biomedical research 

program - Oxygen-helium diving resulting in high pressure 

nervous syndrome (human, animals) 
P50HL-14218-07 0018 Pulmonary SCOR-Newborn lung 

center - Whole body buffering in acute hypercapnia (dogs) 
POIHL-14388-07 0191 Regulation of the circulation in 

pathological states Regulation of chloride transport in 

epithelial membranes (turtles) 
ROlHL-16135-05 Mechanisms of cardiac autorhythmicity 

(dogs, bats) 
ROIHL 17963-04 Human erythrocyte carbonic anhydrase 
ROlHL-1835103 Brain metabolism, acid-base balance. 

and respiration 
ROlHL-18606 04 Pathogenesis and measurement of 

pulmonary edema (human, rabbits, dogs) 
ROlHL-19008-02 Carbon dioxide diffusion in lung and 

muscle tissues (dogs) 
R23HL-19601-01 Cardiac response to chronic metabolic 

acidosis (rats) 
POlHL-19737-02 0004 Cellular and molecular aspects of 

respiratory physiology - Rapid reactions and erythrocyte 

exchanges of blood during respiratory transport 
CARBONIC ANHYDRASE 

SEE DEHYDRATASES. CARBONIC ANHYDRASE 
CARBONIC ANHYDRASE INHIBITORS 

SEE ENZYME INHIBITORS. CARBONIC ANHYDRASE INHIBITORS 
CARBONYL COMPOUNDS 

ROlHL-18163-04 Red cell membrane effects due to 
oxidizing agents 

CARBOPOLYCYCLICS 

SEE CYCLICS. CARBOPOLYCYCLICS 
CARBORANES 

SEE METALS. BORON COMPOUNDS. BORANES 
CARBOXYL GROUPS 

ROlHL-14680-07 Specific enrichment of myoglobins for 

carbon 13 NMR (catacea) 
ROlHL-16471-05 Cardioactive alloyohimbines and related 

indole alkaloids 
ROlHL-17930-03 Platelet membrane function -Assessment 

and application (animals) 
ROlHL-19278-03 Ristocetin induced platelet aggregation 

(human) 



•Excludes routine methodokjgy OR covers only general projects which preclude indexing 
Oneirted significantly to above subject 



at the specific level. 



M Grant has subproiects describing specific research aspects. 
See Appendix for mvestigator's name and grant number. 



(contd) 



CAR 

ROlHL-20079-02 0001 Thromboresistant material ■ Active 

and passive thromboresistant surfaces 
ROlHL-20764-02 Elaslin and calcification in pulmonary 
and vascular disease (human, mammals) 
CARBOXYL GROUPS, CARBOXYLATION 
♦* POlHL-1141411 0035 Thrombosis and atherosclerosis 
program • Mechanism of action of vitamin K (rats) 
ROlHL-14847-07 Mechanism of action of vitamin K and 
anticoagulants (rats) 
•* ROlHL-20161-02 Role of gamma-carboxyglutamic acid in 
blood coagulation (human, cattle) 
ROlHL-20577-03 The mechanism of action of vitamin K 
ROlHL-21543-02 Structure-function relation of blood 
clotting proteins (rabbits) 

CARBOXYLATION 

SEE CARBOXYL GROUPS, CARBOXYLATION 

CARBOXYLESTERASES 

SEE CARBOXYLIC ESTER HYDROLASES, CARBOXYLESTERASE 

CARBOXYUC ACIDS, ENOIATES 

ROlHL-21367-02 Polyether ionophores-Synthesis of X537A 
and analogs 
CARBOXYLIC ESTER HYDROLASES, ARGININE 
ESTERASE 

P50HL14153-07 0015 Johns Hopkins Lung Center- 
Chronic diseases of airways - Kinins and human lung 

P60HL-1516007 0016 Center for sickle cell disease - 
Kinin and plasm in system in sickle cell disease (human) 

ROlHL-18526-03 Kinins and the human lung 

P50HL-19157-02 0008 Studies in cystic fibrosis and 
bronchiolitis - Serum proteins in cystic fibrosis (human) 

CARBOXYUC ESTER HYDROLASES, 
CARBOXYLESTERASE 

ROlHL-04457-20 Cellular aspects of active transport (fish, 
rabbits, anurans, turtles) 
CARBOXYPEPTIDASE 

SEE PROTEASES AND PEPTIDASES, CARBOXYPEPTIDASE 

CARBOXYPEPTIDASE A 

SEE PROTEASES AND PEPTIDASES, CARBOXYPEPTIDASE 

CARBOXYPEPTIDASE B 

SEE PROTEASES AND PEPTIDASES, CARBOXYPEPTIDASE 

CARCINOGENESIS, CHEMICAL 

SEE NEOPLASTIC TRANSFORMATION, CARCINOGENESIS, 
CHEMICAL 
CARCINOGENS (GENERAL) 

SEE NEOPLASTIC TRANSFORMATION, CARCINOGENS 
(GENERAL) 
CARCINOGENS, CHEMICAL 

SEE NEOPLASTIC TRANSFORMATION, CARCINOGENS, 
CHEMICAL 
CARCINOGENS, DRUGS 

SEE NEOPUSTIC TRANSFORMATION, CARCINOGENS, 
CHEMICAL 

CARCINOID 

SEE NEOPLASMS OF NERVOUS SYSTEM, CARCINOID 

CARDENOUDES 

SEE CARDIAC GLYCOSIDES AGLYCONES. CARDENOLIDES 

CARDIAC ANEURYSMS 

SEE HEART DISORDERS, ANEURYSMS 
CARDIAC ARRHYTHMIA 

SEE HEART DISORDERS, ARRHYTHMIA 

CARDIAC ASSIST 

SEE CAROIOVASCUUR SURGERY, CIRCUUTORY ASSIST 

CARDIAC GLYCOSIDES 

SEE ALSO STEROIDS GLYCOSIDES 
ROlHL-02953-17 Autonomic and cardiovascular 
pharmacology (rats, rabbits, dogs, guinea pigs) 
•* ROlHL-05883-18 0003 Reflex control of resistance and 
capacitance vessels - Cardiac glycosides and sympathetic 

nerve terminals in vascular smooth muscle 
•* ROlHL-05883-18 0004 Reflex control of resistance and 

capacitance vessels - Left ventricular receptors with 

nonmedullated vagal afferents (cats) 
ROlHL-08893-14 Structure and function of membrane 

proteins (human) 
POlHL-10436-13 0014 A multidisciplinary study of 

congenital heart disease - Cardiovascular pharmacology 

(dog) ^ , , 

POIHLI 1351-12 0001 Cellular and molecular 

mechanisms of myocardial function - Ionic control of 

myocardial contractility (animals) 
POlHL-l 1351-12 0010 Cellular and molecular 

mechanisms of myocardial function - Basic ionic exchange 

studies (rats) 
POlHL-13108-09 0017 Clinical heart transplantation - 

Electrophysiology of the transplanted denervated human 

h«irt , , .. 

•* P01HL13108-09 0018 Clinical heart transplantation • 

Etoctrophyjiologic studies of cardiac drugs in the 

demrvited hurt 



82 

ROlHL-13339-08 Pharmacology of developing cardiac 

tissues (chick embryo) 
R01HL-13427-09 Neural control of blood volume (monkeys, 

dogs) 
POlHL-14388-07 0220 Regulation of the circulation in 

pathological states - Pharmacology of the coronary 

circulation in man 

* POlHL-15194-07 0004 Pathophysiology of 

cardiopulmonary dysfunction - Specialized electrophysiology 
fibers-Electrogenic basis of glycosides (mammals) 
ROlHL-15416-06 Cardiovascular control in normal and 
disease states (dogs, baboons) 

* ROIHL 16052-05 Cardiac glycosides-Mechanism of 

inotropic action (dogs) 
POlHL-161 17-05 0005 Ion movements and membranes in 
cardiovascular control - Properties of isolated cell 
membranes (rabbits, cats) 
ROlHL-16549-04 Cardiotonic steroid-NaK ATPase 

interactions (cattle) 
R01HL167 10-03 Myocardial subcellular localization of 
calcium (dogs) 
** P60HL-1726904 0017 National heart and blood vessel 
research and demonstration center - Cell membrane (dogs, 
rabbits) 
P60HL-17269-04 0022 National heart and blood vessel 
research and demonstration center - Medicinal chemistry 
(rabbit, dog, guinea pig) 
ROlHL-17629-03 Developmental aspects of cardiovascular 
function (human, cats, rabbits) 
** ROIHL- 181 85-04 Cardiac glycosides and diuretics-Role of 
NaO pump (dogs) 
ROlHL-18308-03 Comprehensive studies of mucociliary 

transport (dogs) 
ROlHL-187 11-03 Electrophysiology of heart cells (rats, 

chicks) 
ROlHL-19076-03 Vagal control of heart tale-A biophysical 
model (rabbits) 
** ROlHL-191 29-04 Cardiac glycosides-Mechanisms of 

cellular actions 
** POIHL- 192 59-03 0004 Digoxin-specific antibody in human 
therapy - Digitalis-specific antibodies pharmacological 
studies (human, dogs, sheep) 
ROlHL-20230-02 Analysis of the action potential of 
cardiac muscle (sheep) 
** ROlHL-20262-02 Cardiac glycosides and the mechanism 
of the sodium-potassium pump 
POlHL-20552-02 0004 The development and regression of 
cardiac hypertrophy - Ventricular function in experimentally 
induced hypertrophy (hogs, sheep, baboons) 
** ROlHL-20558-02 Cardiac electrophysiology-Effects of ions 

and drugs 
** ROlHL-210 14-01 Mechanism of the inotropic action of 
cardiac glycosides 
ROlHL-21158-02 Cardiac receptors with vagal C-fiber 

afferents (cats) 
R23HL-21262-02 Sodium-calcium interactions in 

mammalian myocardium (rabbits, cats) 
ROlHL-21996-01 Alteration of digitalis and aldosterone 

disposition (rats, rabbits, mice, dogs) 
ROlHL-22039-02 Ion transport in cardiac muscle (dogs, 
rodents, cattle) 
** ROlHL-22079-01 Heart receptor sites for digitalis and 
steroid hormones (animals) 
ROlHL-22484-01 Neural control of cardiac conduction and 

excitation (dogs) 
ROlHL-22568-01 pH effect in heart cells-Influence of 

cardiac drugs (tissue culture, rats) 
ROlHL-22594-01 Reflex control of the circulation in heart 
failure (dogs) 
M POlHL-226 19-01 Cellular mechanisms of heart failure 
** POlHL-226 19-01 0002 Cellular mechanisms of heart 
failure - Structure of sodium, potassium-adenosine 
triphosphatase (lambs, dogs) 
" POlHL-226 19-01 0004 Cellular mechanisms of heart 
failure - Mechanism of action of Na, K-ATPase (sheep, 
cattle) 
POlHL-226 19-01 0008 Cellular mechanisms of heart 
failure - Molecular mechanisms and differential contractile 
responsiveness in VSM (dogs) 
POlHL-226 19-01 0009 Cellular mechanisms of heart 
failure - Sarcoplasmic reticulum in cardiac, skeletal and 
smooth muscle (rabbits, dogs) 
CARDIAC GLYCOSIDES, DIGITALIS 

POlHL-06312-17 0030 Surgical cardiology - Total 

artificial heart (calves) 
POlHL-063 12-17 0051 Surgical cardiology - Diuretic 
therapy on myocardial electrolyte composition and water 
content (human) 
ROlHL-07776-15 Sudden death and cardiac arrhythmias 

(human, dogs, cats) 
ROlHL-08508-15 Cardiac conductivity and automaticity 

(human, dogs, rabbits) 
ROlHL-10608-12 Digoxin-specific antibodies (human) 
ROlHL-10951-11 Neural control of the heart (dogs, rats) 
POlHL-12738-10 0035 Physiologic pharmacology and its 
clinical applications - function and dysfunction of the 
sinoatrial node (human) 
POlHL-12738-10 0076 Physiologic pharmacology and its 
clinical applications - Pediatric cardiac electrophysiology 
and pharmacology (human, dogs) 



CAR 

POlHL-12738-10 0108 Physiologic pharmacology and its 
clinical applications - Developmental electrophysiology and 
pharmacology (human, animals) 
ROlHL-12774-08 Ionic coupling in activation of cardiac 

muscle (frogs, guinea pigs) 
POlHL-13108-09 0008 Clinical heart transplantation - 
Physiology and pharmacology of the transplanted human 
heart 
POlHL-13108-09 0017 Clinical heart transplantation - 
Electrophysiology of the transplanted denervated human 
heart 
ROlHL-13306-08 Pharmacological control of cardiac 

membrane currents (cattle, rabbits) 
ROlHL-13666-06 Pharmacology of genesis of cardiac 

rhythmicity (rats, cats) 
ROlHL-13870-09 Control of myocardial sarcotubular 

calcium stores (dogs) 
P50HL-14187-07 0005 Pulmonary SCOR-Chemical 
mediators in pulmonary vascular responses - Pulmonary 
hypertension and cardiac function (dogs, human) 
POlHL-14388-07 0211 Regulation of the circulation in 
pathological states - Choline acetyltransferase activity 
(rats) 
* POlHL-14388-07 0234 Regulation of the circulation in 
pathological states - Effects of antiarrhythmic drugs on the 
autonomic system (dogs) 
ROIHL- 14545-06 Mechanics of compensatory ventricular 

hypertrophy (dogs) 
ROIHL 14646-05 Pathophysiology of myocardial ischemia 

(dogs, rats) 
POlHL-15194-07 <1004 Pathophysiology of 
cardiopulmonary dysfunction - Specialized electrophysiology 
fibers-Electrogenic basis of glycosides (mammals) 
ROlHL-15522-06 Influence of mannitol on ischemia 

cardiac muscle (dogs, cats, rats) 
ROlHL-15758-06 Catecholamine release in the heart 

(dogs) 
ROIHL- 15985-06 Metabolic and hormonal control of 

cardiac contraction 
ROlHL-16076-06 Electrophysiology of fibrillation and 

defibrillation (human) 
ROlHL-16135-05 Mechanisms of cardiac autorhythmicity 

(dogs, bats) 
POlHL-16607-05 0003 Calcium ion and control of 
cardiovascular function - Calcium transport in 
sarcoplasmic membranes (animals) 
** ROlHL-16611-04 Digitalis-receptor of the heart (guinea 
pigs, rats) 
ROlHL-16656-06 Left ventricular function in exercise 

(dogs) 
P60HL-17269-04 0017 National heart and blood vessel 
research and demonstration center - Cell membrane (dogs, 
rabbits) 
** ROlHL-17451-05 Digitalis effects on cardiac automaticity 
mechanisms 
ROlHL-17452-04 Depolarization induced cardiac 
automaticity (human, animals) 
** ROlHL-17555-05 Distribution and metabolism of labeled 

digitaloids (dogs, guinea pigs) 
** ROlHL-17796-04 Importance of aminosugars in digitalis 

activity (cats, rabbits) 
** ROlHL-17993-04 0007 Ventricular dynamics from 

surgically inserted markers - Digitalis after coronary artery 
surgery (human) 
** ROlHL-18003-05 Digitalis-Mechanism and reversal studies 

(dog, sheep, duck, guinea pig, human) 
** ROlHL-18598-03 Role of Na, K-ATPase inhibition on 

digitalis action 
** ROlHL-18657-03 Pharmacologic studies on neurogenic 
digitalis effects (human, cats, dogs) 
ROlHL-18796-04 Experimental cardiac arrhythmias (dogs) 
ROlHL-19045-03 Electrophysiology of cardiac automaticity 
(human, dogs) 
** POlHL-19259-03 0004 Digoxin-specific antibody in human 
therapy - Digitalis-specific antibodies pharmacological 
studies (human, dogs, sheep) 
** ROlHL-19487-03 Cardiac actions of digitalis (dogs, cats) 
ROlHL-20190-02 Pathogenesis of cardiac hypertrophy 
(dogs) 
" ROlHL-21052-01 Evaluation of a digitalis therapy advisor 
ROlHL-2 11 58-02 Cardiac receptors with vagal C-fiber 
afferents (cats) 
** R23HL-21196-02 Digitalis induced arrhythmia and NAO KO- 
atpase activity (dogs) 
ROlHL-21922-01 Transient currents induced by 
strophanthidin in the heart 
** ROlHL-21996-01 Alteration of digitalis and aldosterone 
disposition (rats, rabbits, mice, dogs) 
ROIHL 22039-02 Ion transport in cardiac muscle (dogs, 
rodents, cattle) 
** ROlHL-22079-01 Heart receptor sites for digitalis and 

steroid hormones (animals) 
** POlHL-22619-01 0003 Cellular mechanisms of heart 
failure - Digitalis induced inotropy in myocardial ischemia 
heart failure (animals) 
POlHL-22619-01 0010 Cellular mechanisms of heart 
failure - Mitochondria in heart and smooth muscle (rabbits, 
rats, dogs) 
ROlHL-22977-01 Role of vasoconstrictor mechanisms in 
heart failure (human, dogs) 

(contd) 



txkitn mutine nwHiodoloiy OR awn only general projwAs which preclude 
' • yi»:iteJ sif ; Jficinthf to above subject. 



indexing at the specific level. 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



CAR 

CARDIAC OLYCOSIDES, DIOITOXIN 

ROIMI 13639 07 ficlou sllonng the coins* ol myoc«idial 

dysfunction (cats) 
ROIHl 1366606 Phaimacoloiy ol genesis ol caidiac 

ihythmicity (fits, cats) 
M POIHL 19259 03 Digoiin specilic antilwdy in human 

therapy 
R23HI 21083 02 Phatmacokinetics ol digoxin and digitoiin 

In humans (lats) 
ROIHI 2199601 Aitacatlon ol digitalis and aldostatone 

disposition (rats, rabbits, mice, dogs) 

CARDIAC OlYCOSIDES, DIGOXIN 

POIHI 10436 13 0002 A multidisciplinai> study o( 

congenital heart disease Myocardial perlormance. 

metabolism and ultrastructure (human, cats, rats) 
ROIHL 10608 12 Olgoxin specific antibodies (human) 
•• POIHI 11310 12 0059 Mechanisms ol cardiovascular 

disease Contractility Acute response to diogoxin after 

heart surgery (children) 
POIHL 12738 10 003S Physiologic pharmacology and its 

clinical applications Function and dysfunction of the 

sinoatrial node (human) 
POIHL 1310809 0008 Clinical heart transplantation ■ 

Physiology and pharmacology of the transplanted human 

heart 
POIHL 1310809 0018 Chnical heart transplantation 

Electrophysiologic studies of cardiac drugs in the 

denervated heart 
ROIHL 1366606 Pharmacology ol genesis of cardiac 

rhythmiclty (rats, cats) 
POIHL 1438807 0220 Regulation of the circulation in 

pathological states Pharmacology of the coronary 



circulation in man 

POIHL 14388-07 0234 

pathological states 



Regulation of the circulation in 
Effects of antiarrhythmic drugs on the 
autonomic system (dogs) 
ROIHL 17631-05 Experimental congestive heart lailure and 

hypertrophy (cats) 
ROIHLI 7796-04 Importance of aminosugars in digitalis 

activity (cats, rabbits) 
ROIHL 1785303 Peripheral circulation in heart failure 
(animals) 
M POlHL-19259-03 Digoxin-specific antibody in human 

therapy 
** POlHL-1925903 0001 Digoxin-specific antibody in human 
therapy - Primary structure of monoclonal antibodies 
(rabbits) 
** POlHL-19259-03 0002 Digoxin-specific antibody in human 
therapy ■ Chemical semi-synthesis of digoxin-specific 
antibody (rabbits) 
** P01HL19259-03 0003 Oigoxin-specific antibody in human 
therapy - Synthesis of dogoxinspecific antibody in 
continuous cell culture (human, sheep) 
POlHL-19259-03 0006 Digoxin-specific antibody in human 

therapy - Core 
R23HL-21083-02 Pharmacokinetics of digoxin and digitoxin 

in humans (rats) 
ROlHL-21996-01 Alteration of digitalis and aldosterone 

disposition (rats, rabbits, mice, dogs) 
R23HL-2230901 Cardiovascular pharmacodynamics in 

immature dogs 
R23HL-22575-01 Factors modifying cardiac digoxin effects 

and content (dogs, cats) 
ROlHL-22750-01 Digoxin in heart failure with sinus 

rhythm (human) 
ROlHL-23980-01 Effects of digoxin therapy in newborn 
and adult sheep 

CARDIAC GLYCOSIDES, OUABAIN 

ROlHL-02953-17 Autonomic and cardiovascular 
pharmacology (rats, rabbits, dogs, guinea pigs) 
P01HL0628518 0199 Cardiovascular-respiratory 
physiology and biochemistry ■ Renal tubular reabsorption of 
sodium chloride (hamsters, rabbits) 
POlHL-06664-17 0039 Cardiopulmonary function In 
remediable vascular disease ■ Transepithelial active 
transport and cell volume regulation (frogs) 
P01HL10436-13 0014 A multidisciplinaiy study of 
congenital heart disease Cardiovascular pharmacology 
(dog) 
R01HL10897-12 Effects of hormones on cardiac 

electrogenesis (rabbits, guinea pigs, dogs) 
POlHL-12157 11 0033 Functions and mechanisms of cell 
membrane ion transport Immunology aspects of active 
Na-K transport in sheep red cell (also human, mice) 
P01HL-12157-U 0049 Functions and mechanisms of cell 
membrane ion transport - Ouabain-insensitive cation 
transport in duck red cells 
P01HL1215711 0052 Functions and mechanisms of cell 
membrane Ion transport - Active electrical properties of the 
synthetic strand 
POlHL-12738-10 0076 Physiologic pharmacology and its 
clinical applications ■ Pediatric cardiac electrophysiology 
and pharmacology (human, dogs) 
POIHL-12738-10 0108 Physiologic pharmacology and its 
clinical applications - Developmental electrophysiology and 
pharmacology (human, animals) 
ROlHL-13666-06 Pharmacology of genesis of cardiac 

rhythmiclty (rats, cats) 
ROIHL- 138 70-09 Control of myocardial sarcotubular 
calcium stores (dogs) 



83 

POIHI 14414 07 0016 Invironmentil Influences on 

cardiorespiratory and cellular lunclionj flloctj ol 
piBSJure on membrane and celluliir tunclion (human, 
rabbits) 
ROIHI 14545 06 Mechanics ol compensatory ventricular 

hypurtrophy (dogs) 
POIHI 14985 0/ QUI 2 Adaptation to hypoxia Direct 

effect ol hypoxia on pulmonary vascular smooth muscle 
(rats, dogs) 
POIHL 15194 07 0004 Pathophysiology ol 

cardiopulmonaiy dysfunction Specialiied electrophysiology 
fibers Eleclrogenic basis ol glycosides (mammals) 
ROIHL 15231 05 Mechanisms ol hemodynamic changes 

during digestion (dogs) 
ROIHL 1575806 Catecholamine release in the heart 

(dogs) 
POIHL 1583506 0018 Study of muscles related to heart 

disease Pharmacology of excitation coupling in muscle 
(frog, barnacles) 
ROIHL 16318 21 Biochemistry and pharmacology of Na K 

transport 
P60HL 17269 04 0017 National heart and blood vessel 

research and demonstration center Cell membrane (dogs, 
rabbits) 
ROIHL 1779604 Importance of aminosugars in digitalis 
activity (cats, rabbits) 
** ROIHL 17879 04 Molecular structure of the ouabain 
sensitive ATPase (dogs) 
ROIHL 18053-03 Intracellular ronic activities in heart 

muscle (frogs) 
ROIHL 1859803 Role of Na. K-ATPase inhibition on 

digitalis action 
ROIHL 18599-02 Cardiovascular pharmacology of 

ionophores (dogs) 
ROIHL 19045 03 Electrophysiology of cardiac automaticity 

(human, dogs) 
ROIHL 19129-04 Cardiac glycosides-Mechanisms of 

cellular actions 
R01HL19995-02 Sensory transduction in cardiac 

mechanoreceptors (cats, frogs, rats) 
ROlHL-2026202 Cardiac glycosides and the mechanism 

of the sodium-potassium pump 
ROlHL-21371-02 Energy loss microanalysis of myocardial 

cations 
ROlHL-21525-02 Effect of cations, anions and water upon 

blood vessels (dogs, rats) 
ROlHL-22039-02 Ion transport in cardiac muscle (dogs. 

rodents, cattle) 
ROlHL-22558 01 pH effect in heart cells-Influence of 
cardiac drugs (tissue culture, rats) 

CARDIAC GLYCOSIDES AGLYCONES, 
BUFADIENOLIDES 

ROlHL-181 18-04 Total synthesis of cardiac aglycones 
CARDIAC GLYCOSIDES AGLYCONES, 
CARDENOLIDES 

SEE ALSO CARDIAC GLYCOSIDES AGLYCONES, DIGITOXIGENIN 

SEE ALSO CARDIAC GLYCOSIDES AGLYCONES, DIGOXIGENIN 

SEE ALSO CARDIAC GLYCOSIDES AGLYCONES. 
STROPHANTHIDIN 
ROlHL-181 18-04 Total synthesis of cardiac aglycones 
ROlHL-21457-01 C(17)-side group geometry and 

cardenolide activity (cats, guinea pigs) 

CARDIAC GLYCOSIDES AGLYCONES, 
DIGITOXIGENIN 

ROlHL-181 18-04 Total synthesis of cardiac aglycones 
CARDIAC GLYCOSIDES AGLYCONES, 
DIGOXIGENIN 

R01HL-16549-04 Cardiotonic steroid-NaK ATPase 
interactions (cattle) 

CARDIAC GLYCOSIDES AGLYCONES, 
STROPHANTHIDIN 

ROlHL-05883-18 0003 Reflex control of resistance and 

capacitance vessels - Cardiac glycosides and sympathetic 

nerve terminals in vascular smooth muscle 
ROlHL-09914-13 The myocardium in diabetes mellitus 

(dogs, monkeys) 
POlHL-1 1351-12 0001 Cellular and molecular 

mechanisms of myocardial function ■ Ionic control of 

myocardial contractility (animals) 
ROlHL-13639-07 Factors altering the course of myocardial 

dysfunction (cats) 
ROlHL-13666-06 Pharmacology of genesis of cardiac 

rhythmiclty (rats, cats) 
ROlHL-146 14-07 Voltage control of contraction in heart 

(sheep) 
R01HL14899-07 Mechanism and prevention of cardiac 

arrhythmias (dogs) 
R01HL-I6052-05 Cardiac glycosides-Mechanism of 

inotropic action (dogs) 
R01HL161 52-06 Electrophysiology of neonatal to adult 

heart (cats, frogs, guinea pigs) 
ROlHL-17451-05 Digitalis effects on cardiac automaticity 

mechanisms 
ROlHL-19487-03 Cardiac actions of digitalis (dogs, cats) 
ROlHL-21922-01 Transient currents induced by 

strophanthidin in the heart 



CAR 

CARDIAC MUSCLE 

Ml HIAHI MYor.ARDIUM 
CARDIAC OUTPUT 

Sll HI AH I MJNCMON. (.AMiJIAf, Olirplir 
CARDIAC OUTPUT ABNORMALITIES 

Sfl HfAHI UI',(Jkl)( K', OIJIPUI AUNOWMAllTlfS 
CARDIAC TAMPONADE 

Sir HfARI OISORDIRS. CARDIAC lAMPONADF 
CARDIODYNAMICS 

S[[ HEART FUNCTION 

CARDIOGENIC SHOCK 

SEE HfARI DISORDERS, CARDIOGENIC SHOCK 
CARDIOLIPINS 

SEE PHOSPHOLIPIDS, PHOSPHOGIYCERIDES. CARDIOLIPINS 
CARDIOMYOPATHIES 

SEE HEART DISORDERS, MYOCARDIAL DISORDERS 
CARDIOMYOPATHY, HYPERTROPHIC 

SEE HEART DISORDERS. MYOCARDIAL DISORDERS, 
HYPERTROPHIC MYOCARDIOPAIHY 

CARDIPPROTECTIVE AGENTS 

SEE CAROIOVASCUUR AGENTS, CARDIOTONIC AND 
CARDIOPROTECTIVE DRUGS (GENERAL) 

CARDIOPULMONARY BYPASS 

SEE CARDIOVASCULAR SURGERY, CIRCULATORY ASSIST 
HEART LUNG BYPASS 

CARDIOPULMONARY DISEASE 

SEE RESPIRATORY CIRCUUTORY DISORDERS. PULMONARY 
HEART DISEASE 

CARDIORENAL DISORDERS 

SEE KIDNEY-CIRCULATORY DISORDERS 
CARDIOTONIC DRUGS 

SEE CARDIOVASCULAR AGENTS. CARDIOTONIC AND 
CARDIOPROTECTIVE DRUGS (GENERAL) 

CARDIOVASCULAR AGENTS 

SEE ALSO CARDIOVASCULAR DISORDERS CHEMOTHERAPY 
ROlHL-01486-23 Quantitative study of T-wave mechanisms 

(human, rabbits, dogs, chickens) 
ROlHL-03181-21 0025 Hemodynamics as applied to 
surgical problems - Vascular stenosis (dogs) 
" P01HL-06285-I8 0186 Cardiovascular-respiratory 

physiology and biochemistry - Leukocyte hormone receptors 
and cyclic nucleotides (tissue culture) 
POlHL-06835-17 0039 Cardiovascular disease - 
Reversibility of vascular changes in renal hypertension 
(rats) 
POlHL-06835-17 0051 Cardiovascular disease ■ 
Cardiopulmonary volume in hypertension (human) 
ROlHL-10503-13 Cardiac ion transport and ultrastructure 

(rats, guinea pigs, rabbits) 
ROlHL-10582-12 Thrombosis and hemostasls-Analysis, 

methods and standards (human, cattle, venom) 
ROlHL-10608-12 Digoxin-specific antibodies (human) 
M POlHL-12373 10 Cardiopulmonary physiology and 
pathophysiology 
POlHL-1237310 0005 Cardiopulmonary physiology and 

pathophysiology - Characterization of fetal and neonatal 
myocardium (human, cats) 
ROlHL-13636-08 Effects of pharmacologic agents on heart 
metabolism (human, rodents) 
M POlHL-14388-07 Regulation of the circulation in 
pathological states 
POlHL-14414-07 0010 Environmental influences on 

cardiorespiratory and cellular functions • Pressure effects 
on cardiac electrical phenomena (animals) 
R01HL15985-06 Metabolic and hormonal control of 

cardiac contraction 
ROlHL-16471-05 Cardioactive alloyohlmbines and related 

indole alkaloids 
R01HL-16474-05 Antibiotic-ion interactions (model 

membranes) 
POlHL-16607-05 0003 Calcium ion and control of 

cardiovascular function • Calcium transport In 
sarcoplasmic membranes (animals) 
R01HL16643-02 Fluorocarbon emulsions as artificial 

blood (animals) 
P60HL-1 7269-04 0024 National heart and blood vessel 
research and demonstration center - Section of 
experimental cardiovascular surgery-Core facility 
ROlHL-17341-03 Practical total synthesis of 
prostaglandins 
** ROIHL- 17993-04 0003 Ventricular dynamics from 
surgically inserted markers - Effects of pharmacologic 
agents on left ventricular dynamics (human) 
ROlHL-18084-03 

(calves) 
ROlHL-18096-04 



(primates, dogs) 
ROIHL-1825303 
ROlHL-18590-03 

(dogs, monkeys) 
ROlHL-19000-03 



^&cludes routine methodotogy OR covers only general projects which preclude indexing 
Oiieiited sitniflcantly to alwve subject. 



at the specific level. 



M Gram has subprojeds describing specific research aspects. 
See Appendix for mvestigator's name and grant number. 



Artificial heart and related problems 

Vasoactive agents in splanchnic viscera 

Structure of the palytoxins 

Cerebral blood flow after cardiac arrest 

Irreversible myocardial injury (rats) 
(contd) 



CAR 

ROlHL-1937803 Relation o1 mitochondrial changes to 

cardiac failure (dogs, rats) 
ROlHL-19399-02 Atherosclerosis -Early events and 

regression factors (rats) 
ROlHL-2008002 Surgically induced myocardial edema 

(dogs) 
ROlHL-20190-02 Pathogenesis of cardiac hypertrophy 

(dogs) . . u. ■ 

** ROlHL-22005-01 Intermittent retroperfusion of ischemic 

myocardium (dogs) 
** ROlHL-22269-01 Excitation-contraction coupling in 

enlarged hearts (rabbits) 
** ROlHL-22685-01 Drugs and excitation-contraction coupling 
in heart (animals) 
ROlHL-22718-01 Cardiovascular drug interactions- 
Metabolism models (dogs) 
ROlHL-22732-01 Central organization of cardiac afferent 
nerves (cats, monkeys) 
CARDIOVASCULAR AGENTS, ANTIARRHYTHMIC 
AGENTS 

ROlHL-04666-19 Artificially paced hearts-Technology, 
physiology (human, dogs) 
** ROlHL-05806-18 Analysis of antiarrhythmic agents (dogs, 
rabbits) 
POlHL-06285-18 0155 Cardiovascular-respiratory 
physiology and biochemistry - Therapeutic alterations, 
contractile state in heart failure 
** POlHL-0630818 0011 Mechanisms and therapy of 

circulatory disease Blood flovi and electrical dysfunction 
in ventricular arrhythmia (human) 
POlHL-06308-18 0025 Mechanisms and therapy of 

circulatory disease - Subcellular calcium pools in the 
genesis of arrhythmias (dogs) 
** POlHL-06308-18 0029 Mechanisms and therapy of 
circulatory disease ■ Characterization of the patient with 
recurrent ventricular arrhythmias 
POlHL-06308-18 0037 Mechanisms and therapy of 
circulatory disease ■ Electrophysiology, blood flow, and ANS 
in ventricular fibrillation (dogs) 
ROlHL-0713917 Cardiodynamics and metabolism of 
congestive failure (human, dogs) 
** R01HL07776-15 Sudden death and cardiac arrhythmias 

(human, dogs, cats) 
** ROlHL-08508 15 Cardiac conductivity and automaticity 
(human, dogs, rabbits) 
POlHL-08682-15 0017 Regulation of the cardiovascular 

system - Neurally induced cardiac dysrhythmias (dog) 
R01HL09283-14 Pharmacology of molluscan hearts (also 

rabbits) 
P01HL1043613 0002 A multidisciplinary study of 
congenital heart disease - Myocardial performance, 
metabolism and ultrastructure (human, cats, rats) 
** P01HL11310-12 0078 Mechanisms of cardiovascular 

disease ■ Ventricular arrhythmias in acute myocardial 
infarction (dogs) 
P01HL-n310-12 0087 Mechanisms of cardiovascular 

disease - Electrophysiology and electropharmacology of the 
heart (dogs) 
** POlHL-12738-10 0001 Physiologic pharmacology and its 
clinical applications • Clinical pharmacology of cardioactive 
drugs (human) . 

** P01HL12738-10 0035 Physiologic pharmacology and its 
clinical applications - Function and dysfunction of the 
sinoatrial node (human) 
** POlHL-12738-10 0042 Physiologic pharmacology and its 
clinical applications - Centrogenic cardiac arrhythmias 
(cats) 
•* POlHL-1273810 0044 Physiologic pharmacology and its 
clinical applications ■ Cardioactive drugs and 
electrophysiological properties of cardiac cells (sheep) 
POlHL-12738-10 0076 Physiologic pharmacology and its 

clinical applications - Peniatric cardiac electrophysiology 
and pharmacology (human, dogs) 
POlHL-12738 10 0080 Physiologic pharmacology and its 

clinical applications - Electrophysiology of cardiac muscle 
in the mitral valve (monkeys) 
POIHL 12738-10 0081 Physiologic pharmacology and its 

clinical applications ■ Ultrastructural and electrophysiologic 
alteration of myocardium (human, dogs) 
POIHL 12738-10 0107 Physiologic pharmacology and its 

clinical applications - Blood superfused cardiac fibers 
(dogs) , . . 

•* POIHL 12738-10 0108 Physiologic pharmacology and its 
clinical applications • Developmental electrophysiology and 
pharmacology (human, animals) 
POlHL-1273810 0109 Physiologic pharmacology and its 
clinical applications - Effects of calcium blockers on 
skeletal and cardiac muscle (cats) 
•* POlHL-12738 10 0110 Physiologic pharmacology and its 

clinical applications Physiology and pharmacology of 
arrhythmias (dogs) 
POIHL 1273810 0117 Physiologic pharmacology and its 

clinical applications Ventricular arrhythmias in ischemic 
heart disease (human) 
** P01HL12738-10 0132 Physiologic pharmacology and its 

clinical applications • Coronary occlusions and arrhythmias 
(dogs) 
** POlHL-1273810 0136 Physiologic pharmacology and its 

clinical applications - 
POIHL 13108-09 0008 Clinical heart transplantation - 
Physiology and pharmacology of the transplanted human 
heart 

•Excludes routine methodotogy OR covers only general projects which preclude 
"Onented significantly to above subject. 



84 

POlHL-13108-09 0017 Clinical heart transplantation • 

Electrophysiology of the transplanted denervated human 
heart 
P01HL13 10809 0018 Clinical heart transplantation - 

Electrophysiologic studies of cardiac drugs in the 
denervated heart 
POlHL-13108-09 0019 Clinical heart transplantation - 

Effect of autonomic nervous system on arrhythmias 
(human) 
ROlHL-13375-09 Cellular potential changes causing 

cardiac arrhythmias (dogs) 
ROlHL-1363608 Effects of pharmacologic agents on heart 
metabolism (human, rodents) 
' R01HL13666-06 Pharmacology of genesis of cardiac 

rhythmicity (rats, cats) 
' P01HL14388-07 0234 Regulation of the circulation in 

pathological states - Effects of antiarrhythmic drugs on the 
autonomic system (dogs) 
P01HL144 14-07 0010 Environmental influences on 

cardiorespiratory and cellular functions • Pressure effects 
on cardiac electrical phenomena (animals) 
ROlHL-146 14-07 Voltage control of contraction in heart 

(sheep) 
R01HL147 17-06 Hemodynamics and heart structure - 
Ventricular overload (dogs) 

* ROlHL-1483206 Myocardial cells-Autonomic and rhythmic 

mechanisms (chick embryo, rats) 

* ROlHL-14899-07 Mechanism and prevention of cardiac 

arrhythmias (dogs) 

* ROlHL-15190-07 Physiological basis of arrhythmias and 

their therapy (human) 
P01HL15194-07 0004 Pathophysiology of 
cardiopulmonary dysfunction - Specialized electrophysiology 
fibers-Electrogenic basis of glycosides (mammals) 
ROlHL-15681-06 Coronary flow studies of partially 

obstructed vessels (dogs) 
ROlHL-1574006 In vitro studies on heart cell function 

(rats) 
R01HL16076-06 Electrophysiology of fibrillation and 

defibrillation (human) 
ROlHL-16135-05 Mechanisms of cardiac autorhythmicity 

(dogs, bats) 
ROlHL-17452-04 Depolarization induced cardiac 

automaticity (human, animals) 
ROlHL-17555-05 Distribution and metabolism of labeled 

digitaloids (dogs, guinea pigs) 
ROlHL-17629-03 Developmental aspects of cardiovascular 

function (human, cats, rabbits) 
P50HL-17646-04 0015 Study of ischemic heart disease - 

Protecting ischemic myocardium in patients with evolving 
myocardial Infarction 
P50HL-1 7646-04 0017 Study of ischemic heart disease - 
Dysrhythmia associated with acute myocardial infarction 
(human, cat) 
" P50HL-17648-04 0014 Study of ischemic heart disease ■ 
Antidysrhythmic drugs and mammalian cardiac Purkinje 
fibers (sheep, dog) 
P50HL-17651-04 0022 Ischemic heart disease specialized 
center of research - Electrophysiology -Mechanism and 
pharmacology of arrhythmias (human, dog) 
P50HL-17655-04 0001 Study of ischemic heart disease - 
Intravenous nitroglycerin-Ventricular function and infarct 
size (human, dog) 
P50HL17667-04 0018 Study of ischemic heart disease - 
Arrhythmias in ischemic heart disease (human) 
** P50HL17670-04 0011 Study of ischemic heart disease - 
Pharmacology of ischemic myocardium (dogs) 
P50HL-1768204 0001 Study of ischemic heart disease • 
Studies in acute and chronic ischemic heart disease 
(human) 
R01HL1839804 Mechanisms of delayed and asymetric 

ventricular conduction (human, dogs) 
R01HL18769-04 Studies in survivors of lethal arrhythmias 

(human) 
ROlHL-18783-04 Detection and control of ventricular 

premature beats (human) 
R01HL18794-04 Prospective studies of conduction disease 

(human) 
ROlHL-18795-04 Ischemic arrhythmias-Effect of 

autonomic tone (dogs, rats, guinea pigs) 
ROlHL-18796-04 Experimental cardiac arrhythmias (dogs) 
R01HL18805-04 0004 Sudden cardiac death and the 
onset of myocardial infarction - Sudden death survivors- 
Clinical follow-up and therapy (human) 
ROlHL-19045-03 Electrophysiology of cardiac automaticity 

(human, dogs) 
ROlHL-192 16-03 Characterization of cardiac pacemaker 

activity (cat. dog. rabbit) 
ROlHL-19343-03 Behavioral influences on cardiac 

contractility (monkeys) 
R01HL19398-03 Regional conduction abnormalities and 

arrhythmias (dogs) 
ROlHL-19782-02 Pharmacologic studies on the ischemic 

heart (dogs) 
ROlHL-2021102 Role of taurine in the heart (dogs, rats, 

mice) 
ROlHL-2023802 Prospective bundle branch block study 

(human) 
ROlHL-20579-02 Synthesis of therapeutically important 
alkaloids 
** ROlHL-20754-02 Anesthetic-induced myocardial depression 
(rabbits) 



CAR 

R23HL-21 196-02 Digitalis induced arrhythmia and NAO KO- 
atpase activity (dogs) 
** ROlHL-2122102 Clinical antiarrhythmic and 

pharmacodynamic studies 
** ROlHL-21670-01 Antiarrhythmic studies on 2-substituted 

aminoindenes (dogs) 
♦* ROlHL-21672-01 Antiarrhythmic drug action on VMAZ of 
cardiac cells 
ROlHL-2173501 Electrophysiology after healed myocardial 
infarction (cats) 
** ROlHL-21742-01 Frequency-dependent drug actions in 
cardiac muscle (rabbits) 
ROlHL-21812-02 Actions of drugs and ions on cardiac 

membranes (rabbits, guinea pigs) 
ROlHL-22135-01 Control of calcium fluxes across cardiac 

membranes (dogs, rabbits, guinea pigs) 
R01HL-22239-01 The molecular basis of electrical 

excitability (chick embryos, rats) 
ROlHL-22470-01 Liposome myocardial uptake in infarct 

and ischemia (dogs, rats, mice) 
ROlHL-22484-01 Neural control of cardiac conduction and 

excitation (dogs) 
ROlHL-22568-01 pH effect in heart cells-Influence of 
cardiac drugs (tissue culture, rats) 
** ROlHL-2286201 CNS-mcdiated effects of antiarrhythmic 
drugs (dogs) 
ROlHL-23071-01 Electrophysiology of lethal arrhythmias 

(dog, human) 
ROlHL-2359901 Mechanisms of ischemic rhythm 
disorders (dogs) 
** ROlHL-2362401 Effect of drugs on ischemic cardiac cells 

(dogs, guinea pigs, pigs) 
** ROlHL-2372601 Treatment of ventricular arrhythmias with 
propranolol (human) 
ROlHL-2397001 Mechanisms and control of sudden 
cardiac death (human, dog) 

CARDIOVASCULAR AGENTS, 
ANTIATHEROGENIC AGENTS 

SEE ALSO CHOLESTANE SERIES, CHOLESTEROL INHIBITORS 
SEE ALSO LIPOGENIC INHIBITORS 
** POlHL-06835-17 0064 Cardiovascular disease ■ Studies 
in atherosclerosis (human, animals) 
P50HL-14197-07 0006 Support for center of research on 

arteriosclerosis - Diets and drugs affecting lipid 
metabolism (human) 
P50HL-14230-07 0094 A/S SCOR-Lipids, atherosclerosis 

and thrombosis Studies of atherosclerosis and regression 
(monkeys) 
** R01HL15512-06 Drug treatment of stenosing primate 
atherosclerosis (rabbits, monkeys) 

CARDIOVASCULAR AGENTS, 
ANTIHYPERTENSIVE AGENTS 

SEE ALSO CARDIOVASCUUR AGENTS, VASODILATORS 
R01HL00340-29 Electrolyte disturbance in cardiorenal 

disease (human, dogs, rats) 
POlHL-03174-23 0001 Mechanisms of acute vascular 

reaction to injury • Response of the vascular intima to 
injury (human, rats) 
POlHL-0683517 0030 Cardiovascular disease ■ Synthesis 
and pharmacology of angiotensin antagonists (rats, cats) 
** POlHL-0683517 0037 Cardiovascular disease - Cardiac 
hypertrophy in spontaneously hypertensive rat 
POlHL-06835-17 0040 Cardiovascular disease ■ Benign 

and malignant phase of renal hypertension (dogs) 
P01HL06835-17 0045 Cardiovascular disease ■ Pressure- 

volume-renin relationship in human hypertension 
POIHL-06835-17 0046 Cardiovascular disease - Renin 

activity during salt depletion in essential hypertension 
(human) 
POlHL-0683517 0053 Cardiovascular disease ■ 

Vasodilating drugs (human) 
POlHL-06835-17 0057 Cardiovascular disease ■ Studies 

on cardiac hypertrophy 
POlHL-06835-17 0060 Cardiovascular disease - 

Ventricular performance experimental models of arterial 
hypertension (rats, dogs) 
" ROlHL-07502-13 Phytochemistry of the genus thalictrum 
(dogs, plants) 
ROlHL-07835-17 Experimental hypertension and renal 

circulation (rats, rabbits) 
R01HL10711-12 Cooperative study of treatment of 

hypertension (human) 
ROlHL-10942-09 Study of genetic hypertension in rats 
P01HL11414 11 0014 Thrombosis and atherosclerosis 

program - Role of adrenal in human essential hypertensioij 
POlHL-11678-11 0034 Cardiovascular dynamics and theif 

control ■ Renal function curves in intact dogs 
ROlHL-12648-09 Catecholamine metabolism in 

hypertensive diseases (human) 

ROlHL-1268409 Angiotensin I and converting enzyme in 

hypertension (human, primates, dogs) 

** PO1HL12738-10 0042 Physiologic pharmacology and itsi 

clinical applications ■ Centrogenic cardiac arrhythmias 

(cats) . 

P01HL12738-10 0111 Physiologic pharmacology and itsi 

clinical applications - Cardiovascular pharmacology (dogsM 

POlHL-12738-10 0129 Physiologic pharmacology and ItsI 

clinical applications ■ Receptor specificities and 

metabolism of vasopressin analogs 

R01HL12971-15 Reactions of alkoloids and their analog^ 

(contd) 



indexing at the specific level. 



M Grant has subprojects describing specific research aspects. 
See Appendix for investigator's name and grant number. 



Ctntitl ntuKi control of cmdiovasculai 



CAR 

ROIHl 1318709 
tunction (call) 

POIHI 13?6.' o; 001 1 Artaiiil wall in alhaioscletosis 

Rota ol hypartanjion in atharojclarosis (human, monkay 
dog) 
ROIHL 1358706 Synthasis of tenin Inhibitors and analog 

phojphalidas (rats) 
ROIHL 13595 08 Renin and vascular hyper reactivity in 

hypertension (human, rats) 
ROIHL 13634 08 Renal hypertension in pregnancy (sheep) 
ROIHL 1393606 Microvascular responses in hypertension 

(human, rats) 
ROIHL 14127 16 Methemoglobinemia and antihypertensive 

drugs (cats. mice, rats) 
P50HL 14159 08 0008 Spocialued center of research in 
hypertension Renal tunction and sodium metabolism in 
hypertension (rats, human, rabbits) 
P50HL 1415908 0018 Specialized center of research in 
hypertension Sympathetic nervous system in hypertension 
(rats) 
P50HL 1419208 0001 Specialized center of research in 

hypertension Surgical and medical treatment of 
renovascular hypertension (human) 
P50HL 1419208 0002 Specialized center of research in 
hypertension Hypertensive patients with renal artery 
stenosis 
P50HL 1419208 0003 Specialized center of research in 
hypertension Prostaglandins as mediators of renin 
secretion (human, dog) 
P50HL14192.08 0005 Specialized center of research in 
hypertension Nev« techniques for recognition of 
renovascular hypertension (human, dogs) 
POlHL-1438807 0179 Regulation of the circulation in 
pathological states Cultured muscle cells and their cross- 
innervation in vitro (rats, sheep) 
POlHL-1438807 0194 Regulation of the circulation in 

pathological states • Dopamine-beta-hydroxylase localization 
and release in hypertension 
ROlHL-1491306 Hypertension -Genetic influence of kidney 

(rats) 
R01HL14944-07 Renal vascular reactivity in hypertensive 

patient 
P01HL14985-07 0003 Adaptation to hypoxia - Hypoxia 

and oxygen transport (human, dogs) 
R01HL15047-06 Digital computer analysis of the 

electrocardiogram (human) 
ROlHL-1537806 Ultrastructure of antihypertensive 

prostaglandins 
ROlHL-15528-05 Renin kinetics in hypertensive and 

uremic plasma (human, dogs) 
R0IHL15580-06 Humoral control of pulmonary and 

systemic circulation (animals) 
R01HL15837-06 Renin and cardiac hypertrophy in 

hypertension (rats) 
ROlHL-1 7243-05 Cause of chronic experimental renal 

hypertension (dogs, rabbits) 
ROlHL-1 7335-05 Contractile properties of hypertensive 

arterioles (rats) 
ROlHL-1748704 Adrenergic-vasoregulation interactions in 

hypertension (human) 
ROlHL-1 7749-03 Adrenocortical factors in human 

hypertension (human) 
R01HL-I7754-03 Pathogenesis and prevention of 

hypertension sequelae (rats) 
POIHL-1787104 0009 Kidney, sodium, cardiac output, 
arterioles and hypertension ■ Kidney, sodium, cardiac 
output, arterioles and hypertension 
ROlHL-17897-03 Synthesis of alpha and beta adrenergic 



Mammalian renal microcirculation 



antagonists 
ROlHL-17902-04 

(hamsters) 
ROlHL-17947-04 Experimental renal and neurogenic 

hypertension (human, animals) 
ROlHL-18175-03 Drug taking for hypertension in a rural 

community 
P50HL18318-03 0001 Pathogenesis and complications of 

hypertension - Core clinical program 
P50HL- 183 18-03 0014 Pathogenesis and complications of 
hypertension ■ Arterial metabolism and atherogenesis (rat 
rabbit) 
P50HL-18318-03 0019 Pathogenesis and complications of 
hypertension - Renin-angiotensin system in blood pressure 
regulation (human, rat. dog) 
P50HL- 1 8323-04 0012 SCOR hypertension center - Renin 

as a risk factor (human) 
P50HL- 18323-04 0043 SCOR hypertension center - 
Pharmacology-Renin-aldosterone mechanisms in essential 
hypertension (human) 
P50HL-18323-04 0045 SCOR hypertension center - 

Laboratory programs-Prorenin (human) 
R25HL-18406-03 Adherence to hypertensive medical 

regimens (human) 
R25HL-I84I4-03 Hypertension-Family strategies for 

patient adherence 
R25HL-18418-03 Role of a supporting partner in 

adherence (human) 
R25HL-I8424-03 Blood pressure education in an industrial 

setting (human) 
ROlHL-18579-03 Vasoactive hormones and blood pressure 

regulation (dogs. rats, rabbits) 
ROlHL-18629-04 Influence of aging and hypertension on 
the myocardium (rats) 



8S 

ROIHL 18845 04 Regulation of renal circulation and lalt 

excretion (rats, dogs) 
' ROIHL 18891 02 Hectrolyte Intake and blood pressure in 

hypertension (human) 
ROIHL 19112 03 Atherosclerosis studios (monkeys) 
ROIHL 1928/ 03 The antihypertensive function ol the 

renal medulla (human, rats, rabbits) 
P50HL 1936? 02 0010 A/S SCOR Alheroiclaroili In 

nonhumon primates Antihypertensive therapy 

Atherogenesis in experimental hypertension (baboon) 
ROIHL 19538 03 Synthesis of potential antihypertensive 

agents 
ROIHL 19568 03 Hypertension Analysis of drug and 

behavioral therapies (human) 
ROIHL 20087 02 Developmental processes in pulmonary 

hypertension (rats) 



CAR 



ROIHL 2019401 
pressure (rats) 
ROIHL 2024402 
ROIHL 2024501 
ROIHL 2024701 
ROlHL-20248-01 
ROIHL 2045503 



Brain catecholamines in control of blood 

he impact of hypertension information 
The impact of hypertension information 
The impact of hypertension information 
The impact of hypertension information 
Role of systemic hypertension on diabetic 
retinopathy (human) 
ROIHL 20542 03 Regional hemodynamics in spontaneous 
hypertension (rats) 
• POIHL 20552 02 0002 The development and regression of 
cardiac hypertrophy Effect of treatment on the 
hypertrophied left ventricle (rats) 
POIHL 20552-02 0003 The development and regression of 
cardiac hypertrophy - Muscle mechanics of the 
hypertrophied left ventricle (rats) 
ROIHL 205 7202 0003 Hemodynamic relations to 
metabolism in hypertension Cardiac output and organ 
blood flow in hypertension (rats) 
ROIHL 20604-03 Sympathectomy-Cardiovascular and 

molecular pharmacology (animals) 
ROlHL-21274-01 

analysis (human) 
ROlHL-2139402 

(rabbits) 
ROlHL-21427-02 

patients 
R01HL-21877-01 
ROlHL-22032-01 

(human) 
ROIHL 22216-02 



Prorenin-Physiological and biochemical 

Pulmonary angiotensin-converting enzyme 

Behavioral changes in post infarction 

Iso-renins in the hypertensive rat 
Cardiovascular events in hypertensives 



Vascular mechanisms in renal 

hypertension (dogs) 
ROlHL-22296-01 Autonomic mechanisms in man 
ROlHL-22298-02 Origins of hypertension (human) 
ROlHL-22341-01 Pathogenesis of atherosclerosis in rats 
" R23HL-22345-02 0002 Behavioral cardiovascular 

compliance strategies ■ Compliance with antihypertensive 

medication regimens (human) 
ROIHL-22417-01 Microprocessors in medical applications 

(dogs) 
ROlHL-22506-01 Hemodynamics of the clinical 

hypertensions 
ROlHL-22563-02 Prostaglandins, the kidney and 

hypertension (rats) 
ROlHL-22836-01 The spontaneously hypertensive kidney 

(rats) 
ROlHL-22868-01 Presynaptic regulatory mechanisms in 

hypertension (rats, dogs) 
ROlHL-22896-01 Immediate metabolic fates of kinins and 

angiotensins (rat. rabbit, guinea pig) 
ROlHL-23201-01 

rats) 
ROlHL-23603-01 



disease (rats) 
NOlHV-12434-11 

population 
NOlHV-12435-15 



Mechanisms of hypertension (human. 

Morphogenesis of hypertensive vascular 

Therapy for hypertension in the general 



Therapy for hypertension in the general 

population (human) 
NOlHV-12436-15 Hypertension therapy in the general 

population (human) 
N01HV-I2440-14 Therapy for hypertension in the general 

population (human) 
NOlHV-12442-14 Therapy for hypertension in the general 

population (human) 
NOlHV-2293114 

population 



NOlHV-22937-07 

population 
NOlHV-22938-11 

population 
NOlHV-22939-12 

program center 
NOlHV.22945-11 



Therapy for hypertension in general 
Therapy for hypertension in general 
Therapy for hypertension in general 
Hypertension detection and follow-up 



Cooperative hypertension detection and 

follow-up study (human) 
NOlHV-22971-07 Prevention of coronary heart disease 

(human) 
NOIHV-22976-07 Multiple risk factor intervention trial. 

prevention of coronary heart disease 
NOlHV-22977-08 Intervention trial for the prevention of 

coronary heart disease (human) 
NOlHV-22979-07 Intervention trial for the prevention of 

coronary heart disease (human) 
NOlHV-22980-06 Intervention trial for the prevention of 

coronary heart disease (human) 
NOlHV-22981-10 Intervention trial for the prevention of 

coronary heart disease (human) 



NOIHV ??<)8?0/ IntarvinlioM Irial lor prevantion ol 

coronary heart diuaso (human) 
NOIHV 229810/ Intervention trial for the prevtnlion of 

coronary heart diteate (human) 
NOIHV 33101 06 Development and condur.1 of a muHipIt 

risk factor intervention trial (human) 
NOIHV 33105 09 Intervention trial for prevention of 

coronary heart disease (human) 
NOIHV 33106 06 Inlervenlion trial (or the prevention of 

coronary heart disease (human) 
NOIHV 33108 04 Prevention of coronary heart disease 

(human) 
NOIHV 33109 04 Intervention trial for the prevention of 

coronary heart disease (human) 
NOIHV 331 10 04 Prevention of coronary heart disease 

(human) 
NOIHV 42929 08 Risk factor intervention Irial for the 

prevention of CHD (human) 
NOIHV 42930