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Therapeutical Applications
QXID^OF^YDROGEN
(MEDICINAL*,
andGLYCOZONE
_| BY
■ — THARIES MARCHAND. Chemist.
TREATMENT ni' DISEASES rAUSED
GERM& BACTERIA, MICROBES
FIFTH EDITION.
NEW YORK
Bi^MSi
MjiPiM'
IThe Therapeutical Applications
rE ROXiDE OF Hydrogen
(MEDICINAL),
AND Glycozone
CHARLES MARCHAND, Chemist.
TREATMENT OF DISEASES CAUSED
GERMS, BACTERIA, MICROBES.
FIFTH EDITION.
NEW YORK
1893.
Ck>rvRiGiiT 1898, uy Ciiaklks Makchani*
7^>
TO THE MEDICAL PROFESSION.
I respectfully call attention to the fact, that I am the sole manu-
facturer of Peroxide of Hydrogen (Medicinal).
The commercial article is good enough for bleaching purposes, but
totally unfit, unsafe, and always worthless to use as a remedy.
The low price of this commercial article (which we sell in bulk at
five cents per pound) explains why unscrupulous druggists are base
enough to place the reputation of the physician, as well as the life of
his patient, in jeopardy, by substituting worthless imitations, by which
they pocket a profit varying from 500 to 1000 per cent.
In fact, the substitution of the commercial for the Medicinal Peroxide,
is calculated to work serious injury and destroy the physician's con-
fidence in this most potent remedy.
The unsolicited articles, written by contributors to the medical lit-
erature and published by medical journals, prove that Marchand's
Peroxide of Hydrogen (Medicinal) is the only reliable preparation for
its uniformity in strength, purity and stability, and also for its healing
and bactericide properties, which are considerably increased to the
detriment of its bleaching properties.
The virtues of Charles Marchand's Peroxide of Hydrogen (Medic-
inal) are due to the special process by which it is prepared, and it
retains its germicide and curative power for any length of time when
kept with ordinary care.
lyss
In order to protect the Profession from fraud, Marchand's Peroxide
of Hydrogen (Medicinal) is sold only in i-lb., 8-oz. and 4-oz. bottles,
bearing a blue label, white letters, red and gold border with his sig-
nature; never sold in bulk.
By specifying in your prescriptions Ch. Marchand's Peroxide of
Hydrogen (Medicinal), original package, you will never be imposed
upon.
Glycozone is sold only in i-lb., 8-oz. and 4-oz. bottles, bearing a
yellow label, white and black letters, red and blue border, with his
signature; never sold in bulk.
Insist upon getting these wonderful remedies in their original pack-
ages and you will never be disappointed.
Yours very respectfully,
•tbouloa^i^
Chemist and Graduate of the ^^Ecole Centrale des Arts et
Manufactures de Paris** {France.)
* • • •
• •
• . • •
• •
CONTENTS.
Page
Alveolar Abscess and Abscess of the
Inferior Maxilla — Treatment 38
Abscess of the Vagina — Treatment. . . 34
Action of Ch. Marchand's Peroxide of
Hydrogen (medicinal) upon animal
and vegetable cells 5
Action of Ch. Marchand's Peroxide of
Hydrogen (medicinal) upon infected
surfaces 7
Anthrax — Carbuncle — Treatment 32
Asthma — Treatment by Ozonized Va-
por Inhalations 20
Bronchitis — Treatment 20
Catarrh of the Nose and Catarrh of
the Throat — Treatment 10
Catarrhal Conjunctivitis or Ophthalmia
— Causes — Treatment 40-41
Caution — How to cleanse the curved
spray tube of Marchand's Hand
Atomizer and Ozonizer 20
Comparative chemical reactions be-
tween Marchand's Peroxide of Hy-
drogen (medicinal) and Ozone 4
Cholera — Treatment 44
Consumption — Phthisis — Causes ; Ba-
cillus Tuberculosis — Treatment by
Ozonized Vapor Inhalations 23
Croup — Membraneous Croup — Causes
— Treatment 25
Definition of Pathogenic Micro-Organ-
isms, according to Prof. Koch i
Destructive Action of Ozone Upon
Virus 3
Diphtheria — Cause — Treatment 26
Directions for Using Marchand's Hand
Atomizer and Ozonizer 17
Diseases Caused by Germs or Microbes 2
Page
Dyspepsia — Causes — Treatment by
Glycozone 27
Epidemics are Caused by Absence of
Ozone in the Atmosphere 3
Fistula (Recto- Vaginal) — Treatment. . 35
Gastritis — Catarrh of the Stomach —
Causes — Treatment 29
Gonorrhoea — Gleet — Treatment 35
Glycozone — Important Information. . . 46
Hay-Fever — ^Rose Cold — Coryza —
Causes — Treatment 13
How to Use Marchand's Peroxide of
Hydrogen (medicinal) in Acute Ca-
tarrh of the Nose 16
Important Information on Peroxide of
Hydrogen 5
Inflammatory Diseases of the Eyes —
Treatment 40
Inflammatory Diseases of the Bladder
— Treatment 42
Influenza — I^aGrippe — Causes — Treat-
ment of the I^ocal Symptoms 15
Inhalation of Oxygen and the so-called
"Compound Oxygen" Treatment,
(foot note) Opinion of Karl Von
Ruck, B. S., M. D 7
Laceration, Inflammation and Ulcera-
tion of the Gums — Stomatitis —
Treatment 39
I^aryngitis — Treatment 25
List of Diseases Successfully Treated
by Marchand's Peroxide of Hydrogen
(medicinal) and by Glycozone 36
List of Antiseptics — Their relative bac-
tericide power 8
CONTENTS (Continued).
Page
Marchand's Hand Atomizer and Ozoni-
zer — Description 17
Marchand's Hand Atomizer and Ozoni-
zer — Cuts 18-19
Necrosis and Caries of the Teeth —
Treatment 39
Opinion of the Medical Profession —
Reprint of Articles by Contributors
to the Medical Literature 48-95
Ozcena — Treatment 12
Pharyngitis — Treatment 25
Purulent Conjunctivitis or Ophthalmia
in Children — Treatment 41
Relations of Bacteria to Disease i
Scarlet Fever — Causes — Treatment . 30-3 1
Sore Throat — Quinsy — Tonsilitis and
all Inflammatory Diseases of the
Throat — Treatment 24
Page
Suppurative Diseases of the Ear —
Treatment 42
The Dangers of Carbolic Acid — Re-
sults of Experiments, (foot note) 9
Testing Process for Peroxide of Hy-
drogen 6
The Use of Marchand's Peroxide of
Hydrogen (medicinal) in Dental
Surgery : 37
Typhoid Fever Causes Treat-
ment 3i"32
Typhus — Treatment 44
Ulcer of the Stomach — Causes — Treat-
ment 29-30
Whooping-Cough— Causes— Treatment
21-22
Women's Weaknesses — ^Whites, Leu-
corrhoea, etc. — Treatment 33-34
Yellow Fever — Causes — Treatment ... 33
RELATIONS
BACTERIA TO DISEASE.
The branch of science named Bacteriology was opened to the
medical profession by the classical researches of Prof. Pasteur in the
settlement of the question of spontaneous generation, and in his sub-
sequent studies of the process of fermentation. With the investigations
of that distinguished French savant began our first positive knowledge
of the definite relations of bacteria to disease in the animal kingdom.
Prof. Robert Koch, of Berlin, has contributed widely by his experi-
ments to the progress in knowledge of the etiology of infectious and
contagious diseases.
Owing to the methods which he has devised in order to practically
and easily isolate different species of bacteria, we are now enabled to
follow the phases of their development in pure cultures, under varying
circumstances.
Microscopical examinations show that, during the various stages of
their life, bacteria present different forms and dimensions ; but it is also
demonstrated that one species of bacteria, placed under the same circum-
stances, always present the same forms, and produce the same effects.
Bacteria are principally constituted by an albuminoid substance,
called microproteine.
The pathogenic bacteria only are of the greatest interest to the
physician, and, according to the definition given by Prof. Koch, a micro-
organism is pathogenic when it presents the following characteristics :
First — It must be found in the excretions, secretions, or tissues of
the animal suffering or dead from the disease.
Second — The micro-organism must be cultivated out from the
organism.
Third^h pure culture inoculated in an animal should reproduce
the disease.
fourth — ^The bacteria should be found in the humors or tissues ol
the animal after death.
Pathogenic bacteria are differently affected in their infective power
by the soil in which they grow ; some of them have a limited or local
action, and others produce the infection of the whole system with a
prodigious rapidity.
These facts have been demonstrated from microscopical examina-
tions ; for example, the autopsy shows that the blood of a patient who
died from Diphtheria is invaded with a large number of microbes called
micrococci, the same microbes being detected also in the diphtheritic
membrane, which was at first the seat of this infectious disease.
The microscopical examination of the blood of a patient who died
from Anthrax shows the presence of the Bacillus Anthracis, which was
at first found only in the excretions or pus coming from the infected
surface.
Consequently, the contagion is not always immediate. During this
period of localization of the disease, the microbian element should be
destroyed by a proper medication, in order to prevent its propagation
through the whole system.
Micro-organisms or germs in the atmosphere have been shown by
Ehrenburg to exist in masses or clouds ; so that, in a room containing
infection, a portion of the air may be loaded, while other portions are
nearly free, which would seem to explain cases of escape from septic
or zymotic influences.
It is owing to the presence of these micro-organisms that Profs. Pas-
teur, Koch, Tyndall, and others have been able to establish the germ
theory of disease.
Diseases caused by Germs or Microbes. — It is to the micro-
organisms we are indebted for Catarrh, Ozcena, Hay Fever, Diphtheria,
Croup, Sore Throat, Quinsy, Tonsilitis, Bronchitis, Whooping-cough,
Laryngitis, Pharyngitis, Pneumonia, Consumption, Catarrh of the
Stomach, Women's Weaknesses. Whites, Lcucorrhoea, Typhoid Kever,
Scarlet Fever, Measles, Small-pox, Skin Diseases, Yellow Fever, Chol-
era, Abscesses, Carbuncle, Ulcers, Gonorrhcea, Syphilitic Sores, and
other chronic affections.
It is no wonder, after becoming acquainted with such facts as the
above, that scientists have studied with such care the properties of
antiseptics in order to destroy the germs.
Destructive Action of Ozone upon the Virus. — A fact known
by bacteriologists and chemists is that : All virus is albuminoid,
whether propagative or not ; it is destroyed, or by coagulation rendered
inert, by the oxidizing action of " Ozone," just as it is by contact with
corrosive sublimate and other antiseptics.
Then, it is evident that if some substance could be produced which
would oxidize or destroy these micro-organisms, so as to change their
infectious character, a great benefit would result, providing this de-
stroyer of germs would have no injurious consequences upon the life of
animals.
Such a substance we have in ozone, Os; or condensed oxygen, Ot -f- O.
It is nature's disinfectant.
Houzeau found the air of the country at the height of six feet above
the ground to contain ^B^iVinj o^ '^s weight of ozone, or ^iniVinF °^ '"
volume.
This very small quantity of ozone is sufficient, owing to its wonder-
ful oxidizing power, to destroy germs.
" Ozone " is a normal constituent of fresh air ; its proportion varies
with temperature and electric conditions of the atmosphere.
Billard, Wolf, Boeckel, and Strambes agreed that the cholera, when
it raged in Strasbourg, Berlin, and Milan, coincided with the absence of
ozone in the atmosphere, and that ozone reappeared at the end of the
epidemy.
These observations are in perfect accord with those obtained by Dr.
F. H. Hammond. Dr. Moffatt, Romain Vigouroux, Uhle, and numer-
ous other scientists also attribute the prevalence at time of cholera,
malarious fever, to the absence of ozone in the air.
Is it due to an excessive production of miasms relatively to the
normal proportion of ozone, or is it because " Ozone " is in deficiency
to destroy these germs ?
No one could answer this question, but the positive fact is that :
" If Ozone is in excess, there is no epidemy."
The wonderful antiseptic value of " Ozone " has attracted the atten-
tion of all scientists, and a number of chemists have devised different
methods of its production ; but no one of these processes could be
used to manufacture ozone industrially.
We have in Peroxide of Hydrogen, H,0« a substance which is always
on a strain to break up into water and nascent oxygen, or ozone.
The factthat Peroxide of Hydrogen (medicinal) generatesnascent
oxygen (near to the condition of Ozone), when brought into con-
tact with any infected surfaces is proved by ex
)eriments which 1 have
made in order to establish the comparative chemical reactions between
these two wonderful bactericides, and I now submit to the profession
the results which I have obtained.
COMPAKATIVE CHEMICAL REACTIONS BETWEEN
marchand's peroxide
OF HYDROGEN (medicinal), HjO,, AND OZ
ONE (formula O3),
1
He Oe Solution. „f ^'^ "i^
- Potash and Iodine.
lution in prEScDce of
0.one. ^,f^^l^
[ Potash and Iodine.
("Immediate discoloratton. ,
Hb 0„ Acidnlal- Remit
ed Solulion, nf reaction
Escaping of Oxygen '
Permangaaate of Potash
- Gas and formation of
Purple Solution in pres-
brown Oxide of Man-
anceof
[ ganese.
K( Mnj 0«+4 Ht O.— 2
KHO+Mng H, 0^+4 0,
Peroxide of Iron Salt So-
lution and Ferricya-
nide of Potassium So-
lution mixed together
in presence of
f Ferriq'anide !s trans-
I formed into Ferrocya-
nide of Potassium, giv-
[ ing a blue eoloTMion.
' Same result.
Tincture tjf Indigo in
H,o,Solml,„. ,;^^„
-; Decoloration.
presence of
L?i°L
■J necolnration.
Nitrous a.id in presence
H.O.Mmton. ^^^
( Formation nf NMc
"( Add.
of
,„S£.
] Same result.
H,O.S*„i„. „,«™>^
( Formation of Arsenic
Atscnious Acid in pres-
) -Acid.
ence of
,.,SSL
-J Same result.
Tincture of Guaiacum
mixed with either
Uiood or extract of
11, 0. Soh,,i™. ^,«=",','^
c Result
i Blue coloration, with ef-
■ tervescence and coagn-
f lation of albumen. '
Matt.
- Same reaction. j
Organic substances such
Hj Oi Alkaline Result
) OxidiiinK and llleaching 1
as Cotton. Woolen,
Solution. ..( reaction
( Action.
Silk. Feathers, Hair,
Bones, Ivory, etc., in
O-one.
) Same residl but slower
'"~°°'°'
\ action.
1^^^
IMPORTANT INFORMATION ON PEROXIDE OF
HYDROGEN,
Pure anhydrous Peroxide of Hydrogen yields four hundred and
seventy-five volumes of oxygen; that is, it gives off four hundred arid
seventy-five times its own volume of oxygen. It is a very unstable
liquid compound, having by itself a slight acid reaction to the litmus
paper. Its decomposition into water and oxygen takes place under the
most enigmatical influences. Hence it is not an article of commerce.
Charles Marchand's Peroxide of Hydrogen (medicinal) is really a J^per
cent, solution of the anhydrous peroxide in water; i per cent, solution
yields 4.75 times its own volume of oxygen. Consequently, the Per-
oxide of Hydrogen (medicinal) which I manufacture yields "3^ times-
4.7s"' its own volume of oxygen; viz., a trifie more than fifteen times
its own volume of oxygen gas. It is called a i5-vo!ume solution.
Owing to the unstableness of this compound, my medicinalprepara-
tion is acidulated with traces of hydrochloric acid and traces of phos-
phoric acid. The acid is indispensable in order to preserve the solution
from rapid decomposition, and it is unnecessary to neutralize these
traces of acid, before use, even in the most delicate cases.
All injurious chemicals are eliminated from Charles Marchand's
Peroxide of Hydrogen (medicinal). It is a colorless, almost tasteless,
and odorless fluid. The special process by which it is prepared, con-
siderably increases its healing and bacteride power, to the detriment
of its bleaching properties. It is uniform in strength, purity and
stability; being kept in a cool place, such as a cool cellar, it retains its
germicide power for any length of time.
Action of Charles Marchand's Peroxide of Hydrogen (medic-
inal) upon Animal Cells and Vegetable Cells. — -See report by
Dr. Paul Gibier, page 56; also report by Dr. S. Potts Eagleton, page
68, Experiments made by Bacteriologists prove beyond doubt that:
1st; Charles Marchand's Peroxide of Hydrogen (medicinal) has
HO injurious effect upon animal cells.
ad. It has a very energetic destructive action upon vegetable
cells-microbes.
3d. It has no toxic properties; five cubic centimetres injected
beneath the skin of a guinea pig does not produce any serious result,
and it is also harmless when administered internally.
4th. It is a stimulant to granulating tissues.
Sth. It has no corrosive action whatever upon the healthy mucous
membranes when applied to the treatment of diseases caused by
germs, such as Diphtheria, Scarlet Fever, Whooping Cough, etc.
6th. It is the pus destroyer "par excellence." See article beaded
■"The Necessary Peroxide of Hydrogen," by Ur. Robert T, Morris,
page 55-
Testing Process. — The testing process which is often followed by
chemists is based upon the following reaction which is accompanied
by discoloration of the Permanganate of Potash solution (K, Mn, O,.)
(No. i.)5H,O,+K.,Mn,Os+3H,SOj=-K,SO4-t-2MnSO,+8H,O+100
Experiments made by Prof. Weltzien, Schoene, and Hamel, show
that the chemical reaction which takes place is expressed by the fol-
lowing equation:
(No. 2.) K, Mn, O, + 4 Hi O,— a KHO + Mn, H, O, + 4 O,.
According to reaction No. i, half of the Oxygen liberated comes
from the decomposition of K, Mn, O,, and the other half comes
from HgOj. On the contrary, according to reaction No. z, the total
-amount of Oxygen which is set free, comes from H, O, alone.
Prof. Hamel tests the Peroxide of Hydrogen (according to equation
No. a) with a standard solution of Permanganate, and he measures the
volume of oxygen resulting from the decomposition of H, O,, (See
Ad, Wurtz Diet, of Chemistry, Supplement p. 674.) This Oxygen
represents the totality of the Oxygen contained in Hj Oj. Instead of
decomposing Hg 0, with the Permanganate, the same result may be
obtained by nsing Oxide of Silver (Ag,0) as expressed by the fol-
lowing equation;
(No. 3.) Ag, (0+H,) 0^Ag,+H, 0+0,.
I abandoned the testing process based upon the reaction No, i be-
cause it implies that the oxygen contained in H^ O5 is not "Con-
densed Oxygen," but "Oxygen" in its inactive state. This assertion ,
is wrong, otherwise the reaction expressed by the following equation:
(No. 4.) 5H. (O+O) +K., Mn, Oa+SH, SOi— Ks S0j+2Mn SOi+8MiO-f iOO.
would take place in the same conditions as the reaction No. i, and
such is not the case.
J
The results of my experiments, published on page 4, prove that
oxygen exists in peroxide of hydrogen in Its allotropic state, near to
the condition of "ozone" or "condensed oxygen."
Action of Charles Marchand's Peroxide of Hydrogen upon
Infected Surfaces. — When Peroxide of Hydrogen (medicinal) is
brought into contact with any diseased surface, either of the skin or of
Ihe mucous membranes, its decomposition takes place immediately,
and at first "ozone," which is the resuitof this reaction, coagulates the
albuminoid matters of the secretions, the pus is destroyed, and also
the bacteria. As soon as "ozone" has accomplished its cleansing
effects upon the infected surface, it is readily transformed into ordi-
nary oxygen, owing to its instability.
It is of great importance to notice that water, charged with fifteen
times its own volume of oxygen gas (formula O) under pressure, has.
no similar action whatever on the albuminoid substances, as there is-
no coagulation, and no cleansing effects upon the unhealthy secretions
of the infected surfaces.
This remark was necessary in ocder to establish plainly the differ-
ence between the therapeutical value of Peroxide of Hydrogen and
the Oxygen or the Compound Oxygen treatments.*
Although Ch. Marchand's Peroxide of Hydrogen (medicinal) is rec-
ognized by leading physicians (see the opinions of the medical profes-
the so-caUod "Cc
Ltmcnt," 1 .hall r.:!
Ehbaralcirpoil
Lon:
«. D., Dii
yab Sanlumam
,689, On
pagi
>M follows:
"ZmAaMi-n,
<!/" Oj^gcM.—Vai
duubledJy some benel
uuuula and dig
Otive derangeme
Linademu.
mors comfortabLE itur uicb inha
n -.null qoanlily
o^id.
lll.«.IlOll«l!
I an Dccuioma bul
: tindoDbted Increase i
raia, especially wh<
■lone bad piwi
iditiefficsciou8,co
thoM-netime. Iti range of
ibuulacD
«IBpd«.i.K«
itidary ullogetber
.,.mdit:.™1yocB
idonaUy.lBtw
lylbiagnio
Ihu tempotBry
relief ran tbeieby be si'.'eni and, no ma
he theory
pnkc-tical cjpcrien
iisl, and f
reque
ntly wilbo
««Ult.l)»»>nc
:r diieases. Its miitnrE will
DUS oride,
ll» form of Ibis
so-called ■rampou
.ting
laiwhiDS K>^,
pati.
muwho i
fe«l that 'something
. inhi
btdwH then, i.
raoreteadily. Tbio
'compound oxygen
(iouraha in m^ny localiUcs, >1
ohj.
ict upon t'
sion on page 48) as being the most powerful and reliable antiseptic known,
I now beg to submit to the profession the results of comparative tests
which I have made, in order to demonstrate experimentally the differ-
ence between the bactericide potency of the following chemicals, acting
upon a diphtheritic membrane for the destruction of microbes present
in half a gramme of the said membrane.
Mixture or solution containing 3^ per cent, of the following
chemicals :
QUANTITY or THE M1XTUK.E OR SOLUTION KEQUIR&D TO
ANNIHILATE MICROBES.
Glycozone (harmless) 0.75
Biniodide of mercury 1. 00
Biniodide of silver 1.33
Mnrchand's Peroxide of Hydrogen, medicinal (harmless) a.oo
Bichloride of mercury 3.00
Nitrate of silver. 5.00
Hypochlorite of lime 9,00
Chlorine gas (aqueous solution) r 10.00
Bromine Z4.00
Iodoform (when fresh) 38.0Q
Salicylic acid 40.00
Muriatic acid loc.oo
Carbolic acid llS.oo
Permanganate of potash 140,00
Chlorate of potash ISB.OO
Alum 190,00
Tannin 190.00
Common salt 196.00
Sulphide of calcium 301,00
Boradc acid 300.00
Sulphurous acid 395.00
Lactic acid 360.00
Chloride of iron 37''«>
Thymol, eucalyptus, bicarbonate of soda, lime-water, turpentine,
liave no action at all upon the microbes of a diphtheritic membrane
iHlfdge that our cflorts in phthiao-ttierapy againsi
Iduodoubtedlybusaved if the former could be eilineuislied bf
It ol wi« laws which wonid ob!igc them lo derive Ihrir meaiu of livelihood olherwto*
ihao by trifling with bi
when they are developed ; but they may have, to a certain extent, a
preventive action upon the development of the spores.
The permanganate of potash, hypochlorite of lime, bichloride of
mercury, the aqueous solution of chlorine gas, carbolic acid, nitrate of
silver, etc., destroy the microbes ; but, being poisonous, they have the
most dangerous effect upon the patient's life.
It is worthy of note that the medicinal preparations made by
Charles Marchand, viz., Glycozone and Peroxide of Hydrogen (medi-
cinal), are absolutely harmless. All other chemicals have toxicant, cor-
rosive, or poisonous properties, as is proved by chemical tests ; and
their use is, in many instances, more dangerous than the disease itself.
By referring to the comparative tests published on page 8, it is
easy to notice that Charles Marchand's Peroxide of Hydrogen (medic-
inal), as a bactericide, is i^ times as strong as bichloride of mer-
cury, 2i times as strong as nitrate of silver, 5 times as strong as
iodine, 14 times as strong as iodoform, 20 times as strong as salicylic
acid, 64 times as strong as carbolic acid.*
•TA^ZJaateriff/Ca
rMic Acid.—Th'
e following
eiperiments whlcl
1 1 have made proi
,e beyond
doubt tbe iuigert of applying carbolic 1
icid in Ihe 1
Veatinent i
>f suppurative disea^.
Six dogs were aubmi
tied u Ibe aclion
of this corr
osi™ anliseptic in
the following man
inches of hair on the leg o(
[ each anil
nal upon which the eiperii
Moraing and cvenin
,R an application
ID drops (1
hree pel
: carbolic
add was made upon Ih
rae prepBred aun
faces and c.
mtinued f (
irtenda
One bour or an after
each application
the snrf ace
; was dry,
owing t
)i water.
Hid [hen, as an in. medi
:red byai
imallqu
aolityofpure, con
carbolic add, of which
f these duj
.k,each
prepared eurface of ih
e leu. which was
1 due to thi
: repeated
appUca
on of the
three per cent. aDlailur
1 of carbolic acid
; and three
days later
e of the four other
dogs had
«n ulcer of ibe same n!
produced f
TheM four dogs wer
e ihen luhmitted
ic by my Pero.ide
of Hydrogeo, *hi
weeks Ihorougflly cure
d Ihem.
doRS was again i:ontinued. and on the fiftieth and sixty-second day. respectively, both a
expired from btnod-palBOning. The autopsy showed that Ihe blood of these animals was ii
br Uie bacteria of Davaine, which were detected by a microscopical ejtamlnMloa.
GENERAL DIRECTIONS FOR APPLYING
^H. MARCHAND'S PEROXIDE OF HYDROGEN
(MEDICINAL), HsO.,
IN THE TREATMENT OF DISEASES CAUSED BY GERMS.
NOSE.— THROAT AND CHEST DISEASES.— TREATMENT.
CATARRH OF THE NOSE AND CATARRH Of THE THROAT.
Causes. — Micro-organisms, principally of the micrococcus species,
have been detected by microscopical examinations, by scientific men,
and by myself, in the mucous discharges from the nostrils of persons-
afflicted with this disease. Those germs which are the cause of the
infection are readily destroyed by Charles Marchand's Peroxide of
Hydrogen (medicinal), and there is no danger for the patient to use
this remedy in any quatitity, as it is positively harmless.
Treatment. — By means of an atomizer, made of glass and hard
rubber, spray the nose and the throat copiously and repeatedly twice
or three times every day with a mixture of
I tablespoonful Marchand's Peroxide of Hydrogen (medicinal),
with 4 to TO tablespoonfuls of water (cold or lukewarm)|
according to the degree of inflammation in the mucous membranes of
the nasal cavities ; and, in case of extreme sensitiveness, use even
a still larger proportion of water.
Note.— In the absence of an atomiier, apply the remedy to the nose by sniffing flie
liquid from the hand through the nostrils repeatedly, and gni^le the throat. Il i»
alvays beneficial to swallow some of the remedy.
Do not blow the nose too hard, as it might cause a temporary bleed>
ing.
In chronic cases of long standing, especially at the beginning of the
treatment, when the tenderness of the mucous membrane is excessive
it often happens that the patient will feel, during one hour or so after
each application of the remedy, a partial obstruction of either
the other of the nostrils.
This very unpleasant feeling is often accompanied by frequent
sneezing, which is due to the tickling sensation produced in the nasaj
cavities by the presence of a great quantity of minute bubbles of
" Ozone." being set free from the decomposition of Charles Mar-
chand's Peroxide of Hydrogen coming in contact with the infected
surface. The unhealthy secretions are destroyed by " Ozone," and
the cleansing of the nostrils is made perfect.
In chronic cases, when the middle ear is affected, deafness is very
often the consequence of this disease. Then ozonized vapor inhalations
should follow immediately the spraying of the nose and the throat, and
should be administered by means of Charles Marchand's Hand Atom-
izer and Ozonizer, with a mixture thoroughly made of
half Marchand's Peroxide of Hydrogen (medicinal)
and half chemically pure glycerine.
Renew this mixture every three days. It is important that the above
mixture should be made perfect by shaking the bottle well, otherwise
the spray-tube of the apparatus might be clogged on account of the
syrupy nature of the glycerine.*
The profession well know that the theiapeutical agents used for the
treatment of this disease have been as follows i
Bichloride of Mercury. — Calomel. — Sulphate of Zinc. — Sulphate of Copper.
— Alum.— Nitrate of Silver,— Carbolic Acid. — Salicylic Acid. — Permanganate
of Potash. — Borax.— Boracie Acid.— Subnitrate of Bismuth. — Common
SaJt> — Muriate of Ammonia. — Extract of Eucalyptus.— Thymol. — Cocaine.
— Camphor, etc.
fter 1
or '
I „
•When chronic Calar
rhofthe^
l^eisverytenaci.
lusand painful, i
tisnete;
laatysl night.
before
rairinE, loapply a few
drops of 1
GlycDione to tHe .
iDsirils. SQiffil
hard, as
it will aecelet
■ateUle
"l^ many cases Uie in.
of Chronic Catarrh of Ihe Nose i
s due to
partial or cc
implete
obsmictiQO -f Uie nasal
cavities, caused by some ab,
rormal condlHon
s of growth, differtng ;
When snch Is the case
, apply M.
archand'B Peroxid
ore explained
,mom-
iDg and evening, and ;
iftsr ten <
jr fifteen days, if
disappear, it
wiUbe
necesBary to have asurgical opera
Ltion performed fo
ylhcnbe.
eflected In a very e
ihort time.
After the ewrescence
hasheen
=yed by means c
,f the Ih.
or any
other operaH<«.(«B«w
:liciAou/4
6! Hstd. as it wi/.
1 most likely desi
M). an
abaolute cure Is certain
if Uie Ml
ux;handPeroiide.
earoesily foil
owed.
( easy to understand why Marchand's Peroside of Hydrogen
(medicinal) wiU surely accomplish a pennanent cure, while the above-
mentioned bactericides can give only temporary relief, and they are
apt to injure or destroy both taste and smell.
First — Because Marchand's Peroside of Hydrogen is the most
powerful of all antiseptics yet discovered, (See page 8, " Comparativs-
Tests/')
5«oW— Marchand's Peroxide of Hydrogen (medicinal) is absolutely
harmless when applied externally or administered internally.
Third — The horax, horacic acid, subnitrate of bismuth, muriate of
ammonia, common salt, camphor, eucalyptus, thymol, are not very
dangerous remedies, but their bactericide properties are too limited to
destroy the germs which are the cause of the disease.
On the contrary, Marchand's Peroxide of Hydrogen annihilates these
germs instantaneously, and it leaves the healthy surrounding tissues in
their normal condition. (See " Note," page i6.J
OZCENA, OR PUTRID CATARRH OF THE NOSE.
In case of Ozcena, Marchand's Peroxide of Hydrogen (medicinal)
should be applied three times daily, diluted in the following proportion :
Mix I tablespoonful Marchand's Peroxide of Hydrogen
with 4 to 7 tablespoonfuls of watt-r (cokl nr lukewarm).
It is only in case of extreme tenderness of the mucous membrane
that a weaker solution should be used, as follows : Mix i tablespoonful
of Marchand's Peroxide of Hydrogen with 7 to 10 tablespoonfuls of
water.
Spray the nostrils and the throat successively and copiously with this
diluted Marchand's Peroxide of Hydrogen, or, in the absence of an
atomizer, apply the remedy to the nose by sniffing the liquid from the
hand through the nostrils repeatedly, and gargle the throat.
This treatment is so powerful that the destruction of the microbJao
element takes place immediately, and the putridity which characterizes
this peculiar and repulsive affection is arrested three or four days after
the beginning of its application.
The cure is ordinarily accomplished in four weeks, but in soilie
instances, when the case is of a very long standing — having become
chronic — it requires a longer time to effect an absolute cure.
13
In case of sneezing and obstruction of the nostrils after each appli^
cation of the remedy, see the explanations given, page lo, article
headed " Catarrh of the Nose." *
Marchand's Peroxide of Hydrogen (medicinal) is the most powerful
remedy which can be used in order to subdue this most offensive and
very repulsive disease, and it has no injurious or poisonous conse-
<]uences. (See " Note," page i6.)
HAY FEVER.— R05E COLD.— CORYZA.
Causes. — The microscopica! examination of the unhealthy mucous
secretions and excretions from the nostrils of Hay-fever sufferers
demonstrated the presence of small ovoid micro-organisms, which are
annihilated instantly when brought into contact with Marchand's Per-
oxide of Hydrogen (medicinal).
It is worthy of notice that the degree of susceptibility to the infectious
action of these germs or microbes differs with different people. The
spores and germs which cause this disease do not always find a proper
medium for development in the mucous secretions of different people.
The peculiarity of this disease is that any one who is afflicted with
Hay Fever can foretell every year, almost to a certainty, the day upon
■which the disease will begin, and also the day upon which they will gel
rid of it.
The logical explanation of this is that the conditions of life of
afflicted people are always the same ; that is, " the circumstances and
surroundings of their existence are absolutely alike from year to year."
Thus the microbian causes of the trouble develop under the same in-
fluences every year, at about the same time ; and, consequently, the
disease begins when the atmospheric conditions become favorable for
the development of the spores I have mentioned. These spores grow,
under proper conditions of temperature and dampness, in the mucous
secretions of the nostrils, the microbian affection takes place, and in-
flammation and ulceration of the mucous membrane is the consequence.
These micro-organisms continue their growth as long as these favor-
able atmospheric conditions exist, and they disappear as soon as the
temperature falls and while it remains at a lower degree. Then the
€ffectsdisappearwilh their causes, and the patient gets rid of his trouble.
Treatment. — The causes of Hay Fever being now well established,
it is easy to understand that any remedy having the property to destroy
microbes or germs will surely prevent or cure the disease by removing
the cause, providing this antiseptic remedy will have no injurious
effects upon the surrounding healthy tissues.
In case of Hay Fever, the remedy sliould be applied locally to the
nostrils as a spray, and also by inhalations, in order to subdue the
asthmatic attacks which accompany this very troublesome complaint.
]t has been demonstrated that among the list of antiseptic remedies
published on page 8, Marchand's Peroxide of Hydrogen (medicinal) is
the most powerful bactericide, and it is absolutely harmless.
I have explained on page 7 that : When Marchand's Peroxide of
Hydrogen (medicinal) comes in contact with any open and infected
surface, either of the skin or the mucous membrane, ozone is set free,
the microbes are instantly destroyed, as well as the unhealthy secretions
which are caused by their action, and then the diseased surface is
thoroughly disinfected and made perfectly clean and healthy. The
residue of this reaction is water and a small quantity of coagulated
albumen.
In fact, this Marchand's Peroxide of Hydrogen treatment is based
upon the indisputable results which are obtained when a Hay-fever
patient is going to the White Mountains, where the atmospheric con-
ditions are such that the air contains always a small quantity of ozone.
The constant breathing of this ozonized air accomplishes the cure of
this disease in a very short time.
Hay Fever will always be prevented by an early application of Mar-
chand's Peroxide of Hydrogen (medicinal), in those cases which occur
regularly at known periods of the summer. When the disease has
developed, the same treatment will check it within three or four days,
and the cure is effected in less than two weeks ; but it is advisable to
continue the treatment during the whole Hay-fever season
The remedy should be applied as follows :
First — Spray the nostrils and the throat copiously and repealcdly
twice or three times every day witii a mixture of
I tablespoonful of Marchand's Peroxide of Hydrogen (medicinal^
with 3 to 8 tables poonfuls of water (cold ur lukewarm).
according to the degree of inflammation
Second— 'By means of Charles Marchand's Hand Atomizer and Ozon-
zer, an iiilialation of ozonized vapor should be administered with a
2 thoroughly made of
half Marchand's Peroxide of Hydrogen (medicinal),
half chemically ])ure glycerine.
ind renewed every three days,
irchand's Hand Atomizer and
The above should be carefully mixi
(See description and cuts of Charles
Ozonizer, pages i8-ig.)
The duration of each inhalation should not exceed ten minutes, and
should be taken three to six times daily. Inspirations should be as deep
and prolonged as possible.*
INFLUENZA.— LA GRIPPE.
Causes. — This disease is caused by microbes of a special kind which
act upon both the respiratory organs and the nervous system.
The local symptoms of this infectious disease are a severe naso-
pharyngeal catarrh with headache, sore throat and bronchitis.
The general symptoms are a feeling of lassitude, with acute pains
in the limbs and back, accompanied with fever and profuse perspira-
The internal treatment which may be prescribed by the physician
with an appropriate diet will soon relieve the patient from the general
symptoms, but, the danger is due to complications which frequently
accompany the Influenza, such as laryngitis, bronchitis, acute lobar
pneumonia and pleurisy.
In fact, the local symptoms, viz.: The inflammatory condition of the
respiratory tract must be promptly subdued in order to prevent the
microbian infection from producing dangerous complications.
Treatment of the Local Symptoms. — Owing to its destructive
action upon the germs which are the cause of Influenza, Marchand's
Peroxide of Hydrogen (medicinal) will promptly subdue the inflam-
]t nKsm ImmsdiateLy Asthmt
matory condition iif the respiratory organ?;, ami it should Iji; applied a
follows:
Firs/.— Spray the nostrils anil the throat copiously and repeatedly
every three hours with a mixture made of
[ tablespoonful of Marchand's Peroxide of Hydrogen (medicinal)
with 4 to lo teaspoonfuls of lukewarm water
according to the sensitiveness of the mucous membrane.
Second.— In order lo reach the seat of the disease, deeply located in
the bronchial tubes, by means of Ch. Marchand's Hand Atomizer and
Ozonizer, (p. p. 18-19) inhalations of ozonized vapor must be admin-
istered threS to six times every day with a mixture thoroughly made
of
half Marchand's Peroxide of Hydrogen (medicinal)
half chemically pure glycerine.
Shake well and renew this mixture every three days.
This treatment will not only check the local symptoms, but it will
also prevent the patient from being subsequently troubled with chronic
bronchitis.
Note. — How to Use Marchand's Peroxide of Hjrdrogea
(medicinal) in Acute Catarrh of the Nose. — In case of excessive
tenderness of the mucous membrane of the nostrils, the spraying of
the nose with a cold mixture of Marchand's Peroxide of Hydrogen
(medicinal) with water, may cause a severe pain for a few moments.
In order to prevent this momentary pain from becoming too great^
it is advisable to mix the remedy with lukewarm water instead of cold
water. When such is the case, the required quantity of the mixture
should be made fresh at each spraying.
Dr. Robert T. Morris advises an application of a three per cent.
solution of cocaine before spraying the nostrils with diluted Peroxide
nf Hydrogen (medicinal) in order to quiet the smarting setisation.
(See page 55.)
17
DIRECTIONS FOR USING CH. MARCHAND'S HAND
ATOMIZER AND OZONIZER IN THE
DIFFERENT CASES.
The three ounce glass bottle L is graduated in twelve parts, each
part corresponding to one-quarter of one ounce, so that it is very easy
to mix the mediciAes in the required proportions.
The working of this apparatus will be easily understood by referring
to the illustrations of the apparatus given p. p. 18-19.
First, — The proper mixture of Marchand's Peroxide of Hydrogen
(medicinal) with chemically pure glycerine for administering ozonized
vapor inhalations is thoroughly made in the bottle Z, as is shown on
cuts No. 2 and No. 3.
Then, by quickly and repeatedly pressing the terminal soft rubber
bulb /, the air is forced through the bottle Z, and produces a coarse
spray in the vaporizing bulb A. The concussion of the spray against
the glass breaks up the mixture, and a large amount of fine ozonized
vapor escapes in a continuous flow through the bent glass tube E^ as
represented on cut No. 2, or through the straight glass tube 7% as
shown on cut No. 3.
When the condensed liquid in the bulb A reaches the lower part of
the neck B^ it should be emptied in the bottle Z, by disconnecting
the spray-tube D. Then reconnect the parts, and the apparatus is
again ready for use.
Second. — When the apparatus is needed to spray either the throat or
the nose, Marchand's Peroxide of Hydrogen, (medicinal) is mixed with
the necessary quantity of water in the graduated bottle Z, as shown
on cuts No. 4 and No. 5.
Note. — Some practitioners believe that Peroxide of Hydro-
gen may be inhaled by means of any of the ordinary inhalers,
the same being placed in a jacket vessel of water heated to
120^-140° Fahr. This method is absolutely wrong, for the follow-
ing reason: When Peroxide of Hydrogen is heated to i2o°-i4o® Fahr.,
steam, oxygen (formula O), and only traces of ozone are inhaled by
the patient (see foot note, page 7, article headed "Oxygen Inhala-
tion.") On the contrary, when Peroxide of Hydrogen (medicinal)
vapor is mechanically produced by means of the Hand Atomizer and
Ozonizer the vapor which reaches the diseased tissues has the same
curative properties as Peroxide of Hydrogen itself.
i8
CHARLES MARCHAND'S
COMBINED
HAND ATOMIZER AND OZONIZER.
DESCRIPTION:
Cut No. i.-
This cut represents apparatus when unpacked from its original
box.
Cut No. 2. — This cut represents apparatus ready for inhaling vapor through the nose
in the treatment of Asthma, Bronchitis, and lung diseases.
C.
Cut No. 3.— ^This cut represents apparatus ready for inhaling vapor through the
mouth in the treatment of Asthma. Bronchitis and lung diseases.
19
K.
Cut No. 4. — This cut represents apparatus ready for spraying: the throat.
Cut No. 5. — This cut represents apparatus ready for spraying the nostrils.
Each separate part of the appara-
tus is designated by. the following
letters:
A. — The vaporizing glass bulb, with its
two openings, B and C.
D, — The curved spray-tube (hard rubber).
E. — The bent glass tube.
F. — The slightly curved glass tube.
G. — The straight tip (hard rubber).
H. — The nasal tip (hard rubber).
/. /. — The two soft rubber bulbs.
K. — The soft rubber stopper.
Z.— The glass bottle containing the rem-
edy.
Cut No. 6. — This cut shows the different parts of the Hand Atomizer and Ozonizei
when disconnected.
\]d be kept cleEUi by passing tepid water through it at
get clogged, disconnect the vaporizing
the tip G, and blow both ways through
e through it, as jou would do for any
W
least twice a week. Should
bulb ^ and the bottli
the spray-tube, or pass a thin
ordinary spray atomizer.
The above-described apparatus is entirely made of glass and hard rubber,
because no metal should come in contact with Marchand's Perojiide ol
Hydrogen (medicinal). Use only silver, hard rubber, glass, or porcelain
spoons to measure either Marchand's Peroxide of Hydrogen (medicinal)
Treatment of Asthma. — By means of Ch. Marchand's Hand
Atomizer and Ozonizer, inhalations of ozonized vapor should be admin-
istered three to six times daily. Any similar apparatus made of metal
should never be used in connection with Marchand's Peroxide of
Hydrogen (medicinal).
The action of vaporized Marchand's Peroxide of Hydrogen (medic-
inai), or ozonized vapor, upon the diseased surface of the bronchial
tubes or the ceils of the lungs is similar to the action of this bactericide
upon any open sore or ulcer which is invaded by microbes. The
microbian element is destroyed at the contact of ozone, which is set
free, and the diseased tissues arc purified and made healthy.
The mixture for inhalations which has given the most satisfactory
jults is made of
one-half Marchand's Peroxide of Hydrogen (medicinal),
mixed with one-half chemically pure glycerine.
Mix well together by shaking the bottle, and renew this mixture
every two days.
The duration of each inhalation should not exceed ten minutes, and
after each inhalation, during the winter, the patient should remain
in-doors for fifteen or twenty minutes.
In many cases of long standing it will be found very beneficial to the
patient to take internally every day two or three tumblerfuls of oi
ized water made of
I ounce Marchand's Peroxide of Hydrogen (medicinal)
with 2 pints of water.
This will cleanse and purify the stomach and regulate the boweK *
Bronchitis--Treatment,— By means of ChaHes Marchand's Hand
Atomizer and Ozonizer three inhalations of ozonized vapor should be
administered daily.
It is the most efficacious local treatment which can be prescribed to
subdue this disease, on account of the haimless, although very power-
ful, antiseptic and healing properties of Marchand's Peroxide of
Hydrogen (medicinal).
It quickly checks profuse bronchial secretion, and by its stimulating
action upon the diseased tissues of the bronchial tubes an absolute
cure is effected in a -very short time.
Mixture for inhalations :
One-half Marchand's Peroxide of Hydrogen (medicinal)
with one-half chemically pure glycerine.
This mixture should be made perfect by shaking the bottle, and
renewed every three days.
And as a beverage, drink daily three or four tumblerfuls of ozonized
water made of
I ounce Marchand's Peroxide of Hydrogen (medicinal)
mixed with 2 pints of water.
This beverage will have the most beneficial effect upon the stomach,
which is always more or less affected by droppings from the throat.
In this- malady Marchand's Peroxide of Hydrogen (medicinal)
destroys the microbes or germs which are the cause of the disease,
the unhealthy secretions of the bronchial tubes disappear, and the
diseased tissues are made healthy.
Whooping-cough — Causes. — Dr. Burger, of Bonn, Germany,
and Dr. Afifanassieff, of Russia, have demonstrated the presence of
micro-organisms in Whooping-cough sputum. Dr. Afifanassieff has
prepared, with all the precautions, for microscopical experimentation,
a small portion of the expectoration of a Whooping-cough patient,
which showed large numbers of short rod bacteria, part singly, partly
in two and of larger chains.
With pure cultures of these rod bacteria the investigator has made
several experimental inoculations upon animals, A solution of this
culture upon agar-agar, at least eight days old, in one-half a cubic
centimetre of common salt, was made and injected into the windpipe
or lungs of dogs and rabbits, of course under antiseptic precautiotia.
The animals all contracted a disease similar to Whooping-cough,
often complicated with Broncho- pneumonia.
Several died, and the autopsy showed that the mucous membranes
of the bronchi, of the trachea, and even of the nose, are the chief seats
of the injected bacteria.
This same bacterium was found in the lungs and respiratory mucous
membranes of children who died of Whooping-cough.
Dr. Affanassieff considers it to be the true cause of Whooping-
cough, and names it the " bacillus tussis corwulsiva"
Dr, Schwenker (London Laneet, January 7, 1888) and Dr. Wenat
{Medical News, June a, i838) have confirmed Dr. AiFanassieff's obser-
vations.
One hundred cubic centimetres of the pure culture, containing a
considerable quantity of the above-mentioned micro-organisms, have
been submitted to the action of three cubic centimetres of Marchand's
Peroxide of Hydrogen (medicinalj. The complete annihilation of the
bacteria has been effected in less than seventy seconds of contact.
Treatment. — Whooping-cough, being caused by a microbian affec-
tion, requires antiseptic treatment ; and Marchand's Peroxide of Hy-
drogen (medicinal), applied in the following manner, will effect promptly
an absolute cure :
First — Spray frequently and copiously the nose, throat, pharynx, and
larynx with a mixture made of
I lablespoonful of Marchand's Peroxide of Hydrogen (medicinal)
with 4 to 6 tablespoonfuls of water (cold or lukewarm).
The patient may swallow some of the remedy without discomfort, as
it is beneficial and perfectly harmless. Three to four applications
every day will be sufficient in most cases.
Second— ^Y means of the Hand Atomizer and Ozonizer, administer
ozonized vapor three to six times daily, in order to insure the complete
destruction of the microbian element in the respiratory organs.
The mixture for inhalations should be made of
half Marchand's Peroxide of Hydrogen (medicinal)
with half chemically pure glycerine.
Mix well together, and renew the mixture every three days,*
Consumption, Phthisis, Tuberculosis of the Lungfs —
Causes. — It is a well-demonstrated fact that Consumption or Phthisic
is caused by a microbe of a particular species which has been discov-
ered by Dr. Koch, of Berlin, and which is called the Bacillus Tuber-
culosis of Koch-
BacilluB Tuberculosis
in Sputum X 1250 dinmeters.
With pure cultures of this bacillus. Dr. Koch and other scientific
authorities have made experimental inoculations upon animals. A
solution of this culture upon agar-agar was made and injected into the
windpipe or lungs of dogs. The animals all contracted the Tubercu-
losis of the Lungs or Consumption. This bacillus is located in tuber-
cules, and it causes the formation of ulcerated cavities of the lungs.
The bacillus tuberculosis is readily destroyed by antiseptic remedies;
but although the annihilation of the microbian element is accomplished
almost instantaneously by the action of Marchand's Peroxide of
Hydrogen {medicinal), this remedy will not cure Consumption when
the disease has reached such a degree of development that the lung
tissue has broken down. In fact, if it should be possible to bring this
remedy into contact with all parts of the lungs which are invaded by
the bacillus, undoubtedly the cure of Consumption might be always
effected by the ozonized vapor inhalations.*
Treatment. — Frequent and deep ozonized vapor inhalations should
be administered three to six times daily, with a mixture of
a to 3 tablespoonfuls of Marchand's Peroxide of Hydrogen (medicinal)
with I tablespoonful of chemically pure glycerine well shaken.
Renew this mixture every three days.
The duration of each inhalation should not exceed ten minutes, and
inspiration should be as deep and as prolonged as possible. The
remedy will reach the lungs if administered either through the nose or
mouth, by means of Charles Marchand's Hand Atomizer and Ozonizer.
{See page i8.)
Remain in-doors for fifteen to tvremy minutes after each inhalation
during the cold weather.
It is easy to understand that, the ozonized vapor coming into con-
tact with the bacillus tuberculosis, located in the ulcerated cavities of
the lungs, " ozone," which is set free, destroys the microbian element
immediately, as explained before on page 7.
When Consumption has not taken developments beyond its first or
second stages — that is, when the ulcerated cavities caused by the bacil-
lus tuberculosis are limited and can be easily reached by the ozonized
vapor — the above treatment prevents absolutely the spreading of the
infection and a cure is effected. But in all cases of Consumption, no
matter at what stage of the disease, the relief of the patient will be
surely and quickly obtained by the Marchand Peroxide of Hydrogen
treatment.
Ozonized vapor has no corrosive, toxic, or injurious action upon the
healthy tissues of the lungs ; on the contrary, it has very powerful
stimulating properties. In addition en the inhalations, the administra-
tion of three tumblerfuls daily of ozonized water, made of
ij ounces of Marchand's Peroxide of Hydrogen (medicintil)
with 2 pints of water,
after each mea], will be found very helpful to the relief 0/ the patient
Sore Throat, Angina, Quinsy, Tonsilitis, and all Inflam-
matory Diseases of the Throat.
Treatment. — Spray or gargle the throat copiously and frequently
vith a mixture of
I tablespoonful of Marchand's Peroxide of Hydrogen (medicinal)
with 3 to 6 tablespoonfuls of water (colo or kikewarni;.
You may swallow the remedy without discomfort, as it is rather bene-
ficial. In case of Tonsillar Abscesses gargle more frequently (every
two hours, for instance), in order to destroy surely and quickly the pus
which is present.
Laryngitis. — Marchand's Peroxide of Hydrogen (medicinal) is cer-
tainly the safest remedy to apply in order to subdue this dis
Spray or gargle three times every day with a mixture made of
I tablespoonful Marchand's Peroxide of Hydrogen (medicinal)
with 2 to 6 tablespoonfuls of water,
and swallow a portion of the remedy.
In many cases, ozonized vapor inhalations will accelerate the cure.
Pharyngitis.— Spray or irrigate copiously the pharynx three tiroes
every day with a mixture of
I tablespoonful Marchand's Peroxide of Hydrogen (medicinal)
with 3 to 7 tablespoonfuls
of V
swallow a portion of the remedy, and administer ozonized vapor inhala-
tions morning and evening.
Appropriate internal medication may accelerate the cure.
Croup, Membraneous Croup. — This disease seems to be caused
by the same specific virus as Diphtheria, but it shows a milder grade of
infection ,
When fully developed, whitish spots or membraneous exudations are
observed in the larynx. After the membrane la once formed, if left
alone it may be cast off in the form of a cylinder, in bands or shreds.
Some recent experiments have proved that Marchand's Peroxide of
Hydrogen (medicinal) destroys these membranes after a short contact,
and by its curative properties the diseased surface is rendered healthy.
In case of Membraneous Croup, the nose, throat, mouth, pharynx,
and larynx should be flooded every two hours with a mixture of
I tablespoonful of Marchand's Peroxide of Hydrogen (medicinal)
with 4 to 6 tablespoonfuls of water (cold or lukewarm).
The membranes are destroyed, and by using this remedy frequently
and very freely you prevent their reprodutrtion.
In this way the physician will observe that the inflamed parts are
thoroughly and quickly cured, and there is no danger of the patient
being exposed to the suffocation resulting from the development of
these infected membranes.*
Diphtheria — Causes. — Diphtheria is at first a iocai disease (see
lich is secondarily propagated to the general org'anism by
intagious virus located about the tonsils; this virus is an albuminoid
^bstance invaded by a large numlier of bacteria called micrococci.
Marchand's Peroxide of Hydrogen (medicinal) destroys this virus
instantaneously, and it has no injurious effects upon the surrounding
healthy tissues.
These cuts illustrate a well-developed case of Diphtheria before
and after its cure by use of Marchand's Peroxide of Hydrogen (medici-
nal). Time taken to destroy the micrococci was less than 70 seconds.
MHKQifled Diphtheritic Membrane, BOO
iu are ileatroyed; the f
Directions for Use. — Spray or gargle copiously, every two hours,
the nose, throat, mouth, pharynx, and larynx with a mixture of
I tablespoonful Marchand's Peroxide of Hydrogen (medicinal)
with 3 tablespoonfuls of water (cold or lukewarm).
It is beneficial to swallow the remedy, or a portion of it. in gargling.
The virus or germs are readily destroyed from the contact with
Peroxide of Hydrogen (medicinal), and the contagion is therefore
prevented.
When Diphtheria is well developed it is necessary to spray tfee
child's nostrils, throat, mouth, pharynx, and larynx more frequentlyi
with a mixture made of
I lablesjjoonful Marchand's Peroxide of Hydrogen (mt-dicinal)
[ with I tablespoonful of water (cold or lukewarm.)
Phospha'
s. J Magn
Dr. Geo. B.Hope of the Metropolitan Throat Hospital of New York^^
ind many other leading physicians, recommend the use of Marchai
I'eroKide of Hydrogen (medicinal) full strength, particularly when
disease spreads rapidly.
The remedy may be applied by means of a camel's hair brush (fre« J
from any metallic parts) or by meansof an ordinary atomizer entireiyJ
taade of glass or hard rubber.
Any portion of the remedy which finds
Stomach is beneficial rather than harmful.
Adults and children old enough to gargle the pharynv
mouth will gel a better effect in this way*
Dyspepsia— Predisposing Causes.— Deficient gastric secretion; J
with resulting fermentation of food, is perhaps the most prevalenST
icause of dyspepsia.
' The two main constituents of gastric juice, namely, acid and pepsin,
jnay be deficient in quantity or disturbed in their relative proportions.
)A certain amount of acid is absolutely essential to the digestive process,
'While a small amount of pepsin may be sufficient to digest a largft- ■
itRmount of albuminoid food.
! Bidder and Schmidt have made repeated analysis of pure gastril
Juice, and their results are confirmed by theanalysisof five specimens!
wf garlric juice, free from saliva, and taken by Charles Mai
t;dogs.
The gastric juice of a dog is composed of:
I Water
< Pepton and pepsin
Free muriatic add
i Alkalitie chlorides.
;, Ammonium chloride
' Chlorine
The most careful analysis proved beyond doubt that fresh gastrifea
Huice contains only one mineral ac»d — that is, muriatic acid.
28
Exciting Causes. — The profession well know that excess in eat-
ing and drinking, imperfect mastication and insalivation, the use ol
indigestible and unwholesome food and of alcohol, the imperfect
arrangement of meals, over-drugging, etc., are chiefly the exciting
causes of Dyspepsia, and indigestion is the immediate consequence.
Constipation of the bowels is an almost universal accompaniment of
deranged digestion, and when persistent for years it is apt to lead to
the most disastrous consequences.
The most prominent of the local symptoms of Dyspepsia are ; A sense
of fulness and distention after eating, discomfort during digestion,
lack of appetite and eructations, or heart-burn, flatulence, regurgitations
of food, and sometimes, in acute cases, nausea and vomiting.
Now that I have resumed tiie causes of Dyspepsia, which produce
a general inflammation of the coats of the stomach, the profession
know that the innumerable remedies which have been recommeaded to
subdue this disease may be classified as follows :
^(W/— Remedies having a stimulating action upon the secretion and
muscular coats of the stomach.
6'«(?na'— Introduction in the stomach of a necessary amount of one
or several of the constituent elements of the gastric juice, in order to
make it normal.
Third — Remedies having the property to lessen the abnormal irri-
tability.
Fourth — Remedies having the property to facilitate digestion.
It is evident that any remedy which will restore the coats of the
stomach to their normal condition will contribute to effect an absolute
cure, providing the patient will observe a proper regimen.
Glycozone, by its wonderful antiseptic and healing properties, not
only prevents the fermentation of the food in the stomach, but it cures
also the inflammation or irritation of the mucous membrane in a very
short time. Consequently, the most powerful and efficacious treatment
to be applied, in order to remove the causes of Dyspepsia, can be for-
mulated as follows :
Before or after each meal administer i teaspoonful of Glycozone in
a wineglass nearly filled with water, stirred and taken three or four
times daily.
Use no other remedy.
The digestion is accomplished, from the beginning of its applicatloOi
■without the least discomfort. The rehtf is almost immediate, and a
cure absolute, if earnestly used.
After a few days the secretion of gastric juice is made normal, and
the most acute cases of Dyspepsia, those of long standing, are perma-
nently cured within two to six months of this treatment, when all othev
remedies have failed.
Catarrh of the Stomach, or Gastritis, Chronic or Recent.—
The mucous membrane of the stomach is usually the seat of thi:>
disease.
Among the direct exciting causes of gastric inflammation, corrosive
poisons and the excessive use of alcohol are recognized to be more
prevalent than any others.
Chronic Catarrh of the Nose is often the cause of Gastritis on
account of the large quantity of infected secretions which, after de-
veloping in the nasal cavities, find their way into the stomach.
The immediate consequence of that dropping is to produce an
inflammation of the coats of the stomach, and httle by little the
microbian infection produces a general morbid condition having the
symptoms of Catarrh of the Stomach,
In cases of acute Catarrh of the Stomach the autopsy shows that
the mucous membrane is covered with a thick, tenacious, stringy
mucus ; the secretion of gastric juice is very imperfect, and the diges-
tion of food cannot be accomplished.
Glj'cozone, by destroying the morbid element which is the cause
of this disease, rapidly subdues the inflammatory condition of the
coats of the stomach, and then the mucous membrane, being restored
to its normal state, the secretion of the gastric juice will become
regular, and the digestion will not be disturbed any more.
Treatment. — Administer, three or four times daily, before or after
each meal,
I to 2 teaspoonfuis of Glycozone,
diluted in a wineglassful of water, well stirred.
This treatment will never fail to accomplish an absolute cure within
two to six months, providing the physician will impress upon the mind
of his patient that he should take his meals regularly and with sobriety.
Ulcer of the Stomach.— This disease is due to various causes,
of which the immediate effect is to interfere with the digestion.
Vomiting of food is an indication of Gastric Ulcer, and in severe
Erases it is followed by hemorrhage.
The gastric juice is secreted with deficiency, and in order to remove
the cause of this disorder a powerful antiseptic treatment is required,
The most satisfactory results are obtained :
First — If the patient use as a beverage a small quantity of ozonised
rater at each drink, this ozonized water being made of
r ounce of Marchand's Peroxide of Hydrogen (medicinal)
with 2 pints of water.
The microbian element is readily destroyed by the small quantity of
OBone which is set free at the immediate contact of the ulcerated
surface.
Second — The healing part of the treatment consists in the adminis- .
tration of
1 to 2 teaspoonfuls of Glycozone
diluted in a wineglassful of water, three or four times daily, before or
after eating.
I This treatment is absolutely harmless, and the relief of the patient
' is obtained almost immediately,
II An absolute cure is effected within two to six months.
1 Scarlet Fever — Causes. — It is a proven fact that this disease is
caused by bacteria of the micrococcus species, as shown by the cut
^^^_ below, which illustrates a magnified portion of excretions of an ulcet
^^^Lof the larynx (8oo diameters) taken from a Scarlet-fever patient,
P
F^. I shows the bacteria of
the scarlet (ever.
Fig;, a shows the fibres of the
[issue and globules.
Every physician knows that Scarlet Fever is a contagious affection
to the highest degree, and that it may be communicated by anything
that has touched the patient, such as air, food, clothing, sheets, furni-
ture, curtains, etc. All discharges from bowels, kidneys, nose, mouth,
eyes, ears, and skin are dangerous ; and the poison may remain active
for months or years by means of clothing packed away in drawers.
Treatment. ^The germs which cause this disease are readily
destroyed by Marchand's Peroxide of Hydrogen (medicinal); and the
most powerful local medication is obtained in the following manner :
Spray or gargle the throat copiously and repeatedly every 2 to 3
hours with a mixture made of
I tablespoonful Marchand's Peroxide of Hydrogen (medicinal)
with 3 to 5 tablespoonfuls of water (cnld or lukewarm).*
As a preventive treatment for secondary infection : On the third day
of Scarlatina Fever, the whole body of the patient should be washed,
morning and evening, with equal parts of
Marchand's Peroxide of Hydrogen (medicinal)
and tepid water.
Use a porcelain dish and a clean soft sponge.
This local treatment does not preclude the internal medication,
which may be deemed necessary by the attending physician.
Typhoid Fever — Causes and Treatment. — It is a well-known
fact that contaminated water is the cause of this disease.
The following cut illustrates the typhoid bacille, magnified 1250
diameters, from pure culture :
32
l''Marchand's Peroxide ol Hydrogen (medicinal) destroys those
plcrobes instantaneously. Consequently, a beverage made of
I ounce Marchand's Peroxide of Hydrogen (medicinal)
with 2 to 3 pints of water
Constitutes the most efficacious and powerful antiseptic treatment.
1 always prevents both pysemia and septicEemia.* (See report of
'. H. F. Wiggin, p. 75, also article headed Cholera — Typhus, page 44.)
s antiseptic medication does not preclude the general treatment
"which may be prescribed by the attending physician.
Anthrax— Carbuncle.— This affection, which is caused by the
Bacillus Anthracis, is at first a local disease which requires a veiy
powerful antiseptic treatment, immediately after the carbuncle has
been opened by a surgical operation or otherwise.
The following cut illustrates the Bacillus Anthraci.s, magnified 1250
;, from pure
The Bacillus .Anthracis is readily destroyed by Marchand's Peroxide
of Hydrogen (medicinal.)
Treatment. — Wash or irrigate the sore, morning and evening, with
Marchand's Peroxide of Hydrogen (medicinal), full strength, taking
great care that the liquid should be thrust into the discharging sinuses,
in order to secure the complete destruction of the microhian element;
the pus is also destroyed, and the cleansingof the sore is made perfect.
As a local dressing a double thickness of surgical lint should be
33
soaked into Glycozone and applied to the sore; and a
of oiled silk should be used.
The above local treatment does not exclude the internal medi-
catiun.
Yellow Fever. — According to the recent researches made by Dw'
Paul Gibier, of the Faculte de Medicine de Paris, France, it seems to
be a positive fact that Yellow Fever is caused by bacteria which are
located in the intestines. This theory being supported by other
prominent bacteriologists, the most logical treatment, in order to sub-
due this intestinal infection, is to administer some laxatives in connec-
tioQ with antiseptic remedies. (See article headed Cholera-Typhus p. 44.)
The use of bichloride of mercury solution has been recommended
as a rectal injection, although it should be absolutely condemned,
owing to its corrosive and tosic properties.
A 3 per cent, solution of bichloride of mercury is equivalent, as a
bactericide, to a 2 per cent, solution of Peroxide of Hydrogen (medic-
inal). Then i per cent, solution of Peroxide of Hydrogen (medic-
inal), which corresponds to a 4j^ volume capacity, has the same bac-
tericide power as a ij4 per cent, solution of bichloride of mercury.
(See on page 8, "Comparative Tests.")
Treat men t.^By means of a glass or hard rubber syringe the
physician should prescribe a rectal injection, administered three times
daily, with one pint of a mixture made of
2 ounces of Marchand's Peroxide of Hydrogen (medicinal)
with I pinttjf lukewarm water;
and he will obtain the same disinfectantaction as he would obtain by
using half apint of a i "^ percent, bichloride of mereury solution. The
use of such a quantity of bichloride of mercury should evidently kill
both the germs of the disease and the patient.
WOMEN'S WEAKNESSES.
Whites, Leucorrhcea, etc. — These very troublesome and pain- "
ful diseases require not only an appropriate internal medication, but
also a powerful local antiseptic treatment.
All the remedies prescribed to subdue these affections are more or
less injurious on account of their corrosive, irritating, or poisonous
M
lUt '
I
or 11
fact, thev
ice very fifttii an a^r^ravat
of the
^m^,
^
properties; and,
disease.
On the contrary, Marchand's Peroxide of Hydrogen (medicinal),
powerful than any one of these antiseptics (see page
8) "Comparative Tests"), has, by its stimulating action upon the dis-
eased mucous membrane of the vagina, a prompt and curative effect
Treatment, — By means of either a glass or hard rubber syringe,
copious injections should be administered at least twice daily, morn-
Ig and evening, with a mixture of
1 to 3 ounces of Marchand's
with 1 pint of lukewarm wat
Peroxidf of Hydrogen (medicinal)
according to the tenderness of the infected surface.
The above treatment will promptly accomplish an absolute cure
where all other remedies have failed.
In cases of acute inflammation or ulceration of the womb, injections
should be administered copiously and repeatedly morning and even-
ing, with a mixture made of
k
I to 4 ounces of Marchand's Per
with I pint of lukewarm water.*
xidc of Hydrogen (medicinal])
Abscess of the Vagina— Treatment.^In (.aae of an abscess of
the vagina, the profuse suppuration which follows a surgical opera-
tion, will be stopped by repeated injections administered with Mar-
chand's Peroxide of Hydrogen full strength.
From the time the pus formation is checked, inject repeatedly the
Peroxide (morning and evening) diluted in the proportion of
1 ounce of Marchand's Peroxide of Hydrogen (medicinal)
i ounces of lukewarm water.
1 order to secure a prolonged contact of the remedy with the
eased surface, the patient must lay down on her bed at the tim^j
injects the remedy into the cavity.
When the healthy granulations generate too quickly, under the
stimulating aetion of the Peroxide, it is necessary to inject (three
times every day) a weaker solution made of:
1 ounce Marchand's Peroxide of Hydrogen (medicinal),
with i6 ounces lukewarm water.
After the cleansing of the sore has been accomplished by the above
treatment, apply glycozone on absorbent lint into the cavity.
Fistula (Recto-Vaginal) — Treatment. — At first inject Mar-
chand's Peroxide of Hydrogen (medicinal) full strength until the dis-
charge ceases being abundant. (See article by Dr. Lewis H. Adler,
page 92, also article by Dr. Jos. M. Mathews, page gz.)
Then, morning and evening, inject into the cavity a mixture made
of
I part Marchand's Peroxide of Hydrogen (medicinal)
with 3 to 4 parts of lukewarm water.
The local dressing must be made with glycozone on absorbent lint.
GonorrhcEa. — This disease is known to be characterized by a local
infection of the urethral canal, which is caused by bacteria of the gon-
ococcus species.
These germs, as well as the unhealthy excretions which are present,
are readily destroyed by Marchand's Peroxide of Hydrogen (medic-
inal), and the physician may prescribe three injections every day, to
be administered by means of a glass or hard rubber syringe, with a
1 ounce Marchand's Peroxide of Hydrogen (medicinal)
with 4 to 8 ounces of water,
according to the degree of inflammation; retain this liquid in the
canal for a few seconds.* (See p. $2, Report of Dr. E, Charest, also
page 83, article by W, Roberts, U. S. A.)
The dangers of stricture resulting from the use of caustic or
astringent remedies are absolutely avoided, and the cure is affected in
half the ordinary time if the above treatment is earnestly followed.
The approiiriate internal medication shoulii lie prescrihetl by the
physician.
When the degree of inHammation of the urethra is excessive, each
injection should be preceeded by cocaine or ether for the purpose of
quieting the smarting.
LIST OF DISEASES WHICH ARE SUCCESSFULLY TREATED BT
MARCHAND'S PEROXIDE OF HYDROGEN (MEDICINAL) AND BIT
■■GLYCOZONE."
The fact that Marchand's Peroxide of Hydrogen ^medicinal) is the
most powerful pus-destroyer is so well known among physicians who
have used it that it is acknowledged to be unsurpassed as a cleansing
agent for pus-discharging surfaces, especially in cases otherwise difficult
of access, for the instant it touches pus, "ozone" is set free, effervescence
, takes place, and continues until the pus is destroyed. Physicians may
apply this remedy with perfect safety, and they will always obtain the
most satisfactory results in the treatment of affections caused by genns
or microbes.
For e.\ample, Marchand's Peroxide of Hydrogen should be applied
to the treatmentof the following diseases:
Open Boils, Open Abscesses, Phlegmonous Abscesses, Mastoid Ab-
scesses, "Ulcers (syphilitic or not). Scrofulous Sores, Cancerous Sores,
Bed Sores, Local Gangrene, Broken Ampulla or Blisters, Aphthae or
Ulcerations of the Mouth, Stomatitis, Burns, Herpes Zoster or Zona^
Eczema, Sltin lliseases. Itch, Piles, Fistula, and all microbian affec-
tions.
Treatment, — As a rule, the above-mentioned diseases shonld be
treated an followsr
F/rs/ — I!y means of a glass dropper, or otherwise, apply Marchand's
Peroxide of Hydrogen (medicinal) to the sore, and take care not to
remove the white foam which is generated when this remedy comesin
contact with the diseased surface; let it stand until it disappears,
which occurs in a few minutes.
Then, by means of a glass dropper or a soft camel's hair brush, apply
the Glycozone to the sore and cover it with a double thickness of
surgical Hnt soaked in Marchand's Peroxide of Hydrogen (medicinal).
It is advisable to a))ply both Marrhand's Peroxide of HydrogeS
(medicinal) and glycoaone full strength, until the pus formiitiun is
.trhecked.
When the discharge ceases being abundant, the Peroxide must be
diluted with water and theglycozoneshouldbe thoroughly mixed with
chemically pure glycerine, in order to prevent the healthy granula-
;tions from forndng too quickly.
:THE USE OF MARCHAND'S PEROXIDE OF HYDROGEN
(MEDICINAL) IN DENTAL SURGERY.
Owing to its wonderful bactericide properties, Ch. Marchant
,oxide of Hydrogen (medicinal) is the most powerful remedy to apptn
in order to cure the dental affections which are known to be
by germs or microbes, such as, for example:
Alveolar Abscesses and Abscesses of the Inferior Maxilla.
" Laceration, Inflammation, and Ulceration of the Gums; Stomatitis.
Necrosis and Caries of the Teeth.
The profession well know Chst the therapeutical iigcnis used for the
treatment of these diseases have been as follows:
—Chloride of Zinc— Nitrate of Sil-
With the exception of chloride of sodium, which has no appreciable
destructive action upon the microbian element, the other above-men-
I tiorjed remedies are poisonous, and, owing to their corrosive proper-
[ties, the dentists cannot always limit their action to the affected parts.
Jl The creosote and carbolic acid have such an offensive odor that
Ithey should not be used at all. (See foot-note page 9, article headed,
k"The Dangers of Carbolic Acid,")
On the contrary, Charles Marchand's Peroxide of Hydrogen (medic-
inal) is absolutely harmless; it is almost odorless and tasteless.*
By the healing power of this wonderful remedy, the diseased surface
js made healthy and the surrounding tissues remain in their normal
condition.
It has no destructive action upon the enamel of the teeth.
A tooth, being submitted for several days to the action of Mar-
GKNERAI, DIRECTIONS.
Alveolar Abscess and Abscess of the Inferior Maxilla-
Treatment. — When an Alveolar Abscess is caused by any constitu-
tional derangement, internal medication would necessarily have lobe
prescribed.
The local treatment demanded is such as will destroy the accumu-
lated pus.
At first, the abscess should be broken by a surgical operation ur
■otherwise, then the cleansing and destruction of pus will be accom-
plished instataneously, as follows:
By means of a silver, gold, or platinum syringe, administer into the
■cavity, morning and evening, one or two injections with a mixture of
I part Ch. Marchand's Peroxide of Hydrogen (medicinal)
with 3 to 4 parts of water.
In the treatment of abscesses of the Inferior MLixilla, where there is
no free egress for the pus anil debris, much more energetic treatment
is necessary, and the dentist need not hesitate to administer injections,
morning and evening,
1 part Ch. Marchand'
with 2 parts of water.
1 a mixture of
: Peroxide of Hvdr
igcn (m
ig betH^
In chronic cases, in order to prevent the sore from closing beii
two applications, floss silk or absorbent cotton impregnated with
glycozone, should be applied immediately after each cleansing of the
cavity.
Besides the above local treatment, the mouth should be kept clean
by frequent washings with a mixture of
I table
nful of Ch. Marchands Peroxide of Hydrogi
diluted in half a tumblerful of tepid wate
By following this tre
lent, the diseased
39
after one or two applications, and an absolute cure is effected i
the ordinary time.
Laceration, Inflammation, and Ulceration of the Gums —
Stomatitis — Treatment. — Charles Marchand's Peroxide of Hydro-
gen (merfi[;inal) is the most powerful remedy which niay be applied in
order to subdue these very tenacious and painful affections.
It should be used freely and repeatedly as a tooth-wash, morning and
evening, in the following proportion:
I ounce Medicinal Peroxide of Hydrogen,
dilated with half a pint of water.
Rinse the mouth well, and retain this liquid in the mouth for one
minute or so at each washing. No injurious action whateverupon the
enamel of the teeth need be feared.
The gums are strengthened by this treatment, healthy granulations ■
develop very rapidly, and an absolute cure is quickly effected.
When the above diseases of the gums are caused by constitutional
derangement, interna! medication would necessarily be prescribed.
Necrosis and Caries of the Teeth. — Caries is a vary common
cause of Necrosis. Excessive medication, especially with mercury, will
sometimes produce partial, and, occasionally, total Necrosis.
The profession know that the most common agents that injure the
teeth are originated in the mouth by the decomposition of animal and
vegetable food.
Inflammation of the mucous membrane of the mouth is a common
result of diseased teeth.
The Caries may be constitutional or local, and, if constitutional, the
dentist knows that it may be modified by therapeutic treatment of the
general system.
In all cases of Caries, the aggravation of the disease will always be
prevented by usinij frequently and copiously, as a tooth-wash, a mix-
ture of
I to a ounces of Ch, Marchand's Peroxide of Hydrogen (medicinal),,
'with half a pint of water.
' Rinse the mouth well, at least morning and evening, and retain this-
liquid in the mouth for one minute or sn at each washing.
BaRCHAND'S peroxide of m'DROGEN {MEDICINAL),
USED AS A WASH IN THE TREATMENT OF THE
INFLAMMATORY DISEASES OF THE EYES.
Catarrhal Conjunctivitis, or Ophthalmia — Causes. — The pro-
fession well know that all forms of Conjunctivitis whicli arc
accompanied by secretion are caused by germs which develop under
nfection which
h the impurity of the
unicated bj' conveyance o(
Is, handkerchiefs, etc, with a
more or less favorable circumstani
is contagious to the highest degree.
The virulence of the contagion i
atmosphere, and this disease is c
secretion from one to another, by
prodigious rapidity.
Besides a proper ventilation, it is necessary to isolate sick people,
and also to keep them perfectly clean, in order to prevent the contagion;
for instance, when any form of Conjunctivitis appears in a publicinsti-
tution it is urgent to put all the affected persons apart from the healthy.
Numerous analyses which I have made in order to ascertain the
nature of the remedies ordinarily applied in the treatment to this
(lis
I- that
^ folloi
Nitrate of Silver. — Sulphate of Zinc. — Sulphate of Copper, ^Bichloride of
Mercury. — Red Oxide of Mercury. — Carbolic Acid. — Alum. — Sugar of Lead.
— Taanin. — Borax. — Boracic Acid, — Sulphate of Atropine.— Cocaine.
Although some of these remedies have a destructive action upon
the microbian element which is the cause of this disease, such remedies
should be condemned, owing to their corrosive and irritating jiroperties.
In some instances they have the most injurious effects upon the cornea,
and very often destroy not only the germs of the disease, but also
weaken or destroy the optic nerves, and for this reason their use proyes
more dangerous than the disease itself.
Tannin, borax, and boracic acid are not dangerous remedies; hut
their bactericide power is so feeble that a cure couki not be effcicd by
"r action, since Ihey cannot remove the cause of the infection.
On the contrary, Marchand's Peroxide of Hydrogen (medicinal)
removes the cause of the disease, and Glycozone, by its strength-
ening and curative action, makes the mucous membranes of the eye
grow stronger daily.
Treatment. — First the eyelids should be cleansed by ^ thorough
washing made wit
I ounce Marchand's Peroxide of Hydrogen (medicinal)
with 2 pints of lukewarm water;
then, by means of a glass dropper, apply to the inner portion of the
eye, next to the nose, one, two, or more drops of Glycozone every night
before retiring and the first thing in the morning.
If no dropper is at hand, apply the remedy with a soft camel's-hair
brush, dipped in the Glycozone, to the outer edge of the eye, with an
outward motion of the brush, or it may be applied with the finger. In
whatever manner the Glycozone is applied, it penetrates the inner sur-
face of the eye by simply opening and shutting the eye repeatedly for a
few times.
At first it causes smarting, and often very severe pain for a few
seconds, but it is only momentary and soon passes away.
Purulent Conjunctivitis — Ophthalmia Neonatorum, or
Ophthalmia in Children.— The oculists well know that the Ophthal-
mia Neonatorum, or Ophthalmia in Children, is much more dangerous
in its consequences than the Catarrhal Conjunctivitis.
This disease, which is the most frequent source of blindness in
children, can always be cured if treated as follows:
First cleanse the eyelids by a thorough washing with a mixture of
I ounce Marchand's Peroxide of Hydrogen (medicinal)
with I pint of lukewarm water.
This should be done three times, or at least morning and evening.
every day.
Each cleansing should be immediately followed by the application
of Glycozone. (See explanations given on page 40, article headed
"Catarrhal Conjunctivitis.")
Granulated Eyelids. — Same treatment as Catarrhal GnnjiiMctivitis
In all diseased conditions uf the eyes the patients should expose
themselves to air-draugtits or bright light as little as possible, and the
bowels should be kept open by a suitable internal medication.
SUPPURATIVE AND INFLAMMATORY DISEASES OF THE
EAR— TREATMENT BY MARCHAND'S PEROXIDE OF
HYDROGEN (MEDICINAL) AND "GLYCOZONE."
Owing to its wonderful bactericide properties Marchand's Peroxide
of Hydrogen (medicinal) is of great value in cases of obstinate
chronic suppuration of ttie middle ear, especially in such cases where
it is difficult to reach all the suppurating tract by any local agent.
The fact that it can be forced through theosseoussinuseswithout
danger highly commends its value in the different diseases just men-
tioned.
In case of profuse suppuration, the cleansing and destruction nf
pus should be made perfect by applying the remedy in the following
By means of either a glass or a hard rubber syringe inject into the
cavity, morning and evening, half an ounce of Marchand's Peroxide of
Hydrogen (medicinal), full strength; lettheremedy act during two or
three minutes, and then apply into the ear, as a dressing, a small
quantity of absorbent cotton well impregnated with Glycozone.
Two washings with Peroxide of Hydrogen and two dressings with
Glycozone, applied every day, will cure the most obstinate chronic
case in a very short time.
When the disease is not chronic, the suppuration being relatively
limited, instead of applying Marchand's Peroxide of Hydrogen (medic-
inal), full strength, it should be diluted with lukewarm water, in the
proportion of half-and-half.
The local dressing should be always made with pure Glycozone.
as heretofore explained. (See article headed Peroxide of Hydrogen
and its use in Ear Diseases, by Dr. Walter B. Johnson, page 91.)
INFLAMMATORY DISEASES OF THE BLADDER. PURU-
LENT CYSTITIS. TREATMENT BY MARCHAND'S
PEROXIDE OF HYDROGEN (MEDICINAL) AND
GLYCOZONE.
Cystitis may be acute or chronic; it is always caused by germs.
In all cases of Cystitis the internal medication should be earnestly
observed, and the patient should not drink irritating beverages.
The profession well know that the remedies ordinarily applied in the
local treatment of this disease have rather palliative than curative
properties.
^
In Peroxide of Hydrogen (Medic,
I readily destroys the pus, and also the n
cause of the disease.
Peroxide of Hydrogen (Medicinal) will always prevent the develops
. ment of any affections which very often accompany Cystitis, such t '
\ Phlebitis, Nephritis and Gangrene of the bladdei
Treatment. — By means of a double current hard rubber catheter,
■rigations of the bladder should be made at least twice daily, n
and evening, with six to eight fluid ounces of a mixture made of
two ounces of Marchand's
with one pint of tepid watt
i)f Hydrogen (Medicinal)
At the beginning of the treatment of the chrcinic Cyst
of Marchand's Peroxide of Hydrogen (medicinal) full strength shoulq
)e injected into the bladder, every day.
By using the double current catheter the gas which generates inti?
the bladder finds its way out through the outlet opening.
'n cases of urethritis and also in cases of acute inflammation or
ulceration of the bladder, when the pain is very great, Dr. Robert T.
irris, of New York, recommends that the application of Peroxide of
Hydrogen should be preceeded by Cocaine or Ether, (or the purpose of
quieting the smarting. (See article headed, "The Necessary Peroxide
of Hydrogen, by R. T. Morris, M. D.," p. 55.)
In addition to the above local treatment with Peroxide of Hydrogen,
the introduction into the bladder of a small quantity of Glycozone will
always accelerate a cure.
Every evening before retiring, inject into the bladder one fluid
ounce of the following mixture:
The above r
rbe used in ord
fe
half Glycozone,
half C. P. Glycerine.
ledies are the most powerful topical agents which can
to subdue the inHamm >tory diseases of the bladder.
44
CHOLERA:— JVPHUS
AND
DISEASES OF THE ALIMENTARY TRACT CAUSED BY
MICROBES.
Treatment. — Elmer Lee, A. M., M. D., of Cliieago, III., reports
in the AVrc York Medital Record^ December 17th, 1891, some prac-
tical experiments in the treatment of cholera by irrigation of the in-
testinal cana).
The following cut illustrates his process used at Si, Peiersburgh,
Russia, during the recent epidemic there, 1892.
The irrigation is accomplished by means of a soft rubber lube F,tilK
metre in length and of suitable size to be introduced into the rectum,
in front of the promontory of the sacrum, into and up through the
sigmoid flexure and into the descending colon. This tube which is
connected with a glass reservoir E (see cut), should not be too small
nor too large, in order to facilitate its introduction through the folds
of the signi'iiil pnriinn of the lower bowel. In fact. Ibe greatest dlffi-
culty to be encountered, is 1
the promontory of the sacrui
The tube should be of propei
tuckling upon itself whi
the
t with the obstructing folds of the
fully pass the tube in front of
d enter it into the sigmoid flexure,
iness to prevent it from bending or
nd, {which iu all cases should b& |
rounded), (
tine.
Dr. Lee reports very satisfactory results from a thorough irriga-
tion of the intestines with lukewarm water containing a small pro-
portion of liquid soap made of vegetable oil, potash, and glycerine, in
■connection with peroxide of hydrogen (medicinal), as an internal
treatment.
By following Dr. l.ee's system of irrigation of the intestinal canal,
with a large amount of the above solution (two to three gallons), the
whole amount of infected matter which is present in the intestinal
canal, is mechanically carried away; after which, by a second thor-
ough irrigation of the intestinal tract with one to two gallons of
lukewarm water containing 4 per cent, of Marchand's peroxide of
hydrogen (medicinal), any coma-bacilli which may remain in the in-
testinal tract will be readily destroyed.
In addition to irrigation or washing out of the intestines, Dr. Lee
administers internally peroxide of hydrogen (medicinal), two ounces
, of distilled water, in cupful doses every
Dn of distilled water is made in order to in-
1 the stomach.
e with the first practical ap-
jf infectious diseases of the
diluted with eight
three hours. The additi
crease the bulk of fluid i
It is but justice to credit Dr. Rlniei
plication of irrigation, in the treatmer
ftlimentary
■ The report of his experience at St. Pctersburgh, forms a most val-
^ble contribution to the medical literature of the day. This treat-
teent being practically the removal of poisonous matter and a local
extermination of the coma-bacillus by means of a bactericide which
bas no deleterious effect upon animal cells, is based upon logical
grounds and cannot fail to receive the attention of all scientific men.
■ In consequence of the results obtained by Dr. Lee, it is reasonable
t!o conclude that similar treatment in case of typhus, yellow fever
and other infectious diseases of the alimentary tract, will prove most,
efficacious.
4
46
IMPORTANT INFORMATION REGARDING GLYCOZONE.
Glycozone is a stable compound resulting from the chemical reac-
tion which takes place when C. P. glycerine is submitted under
special conditions, to the action of fifteen times its own volume of
ozone, under normal atmospheric pressure at a temperature of 0" C.
The presence of water (and other foreign substances) in the gly-
cerine, changes the nature of this reaction, so that instead of produc-
ing glycozone, we obtain formic acid, glyceric acid, and other sec-
ondary products having deleterious effects upon the animal cells.
Glycozone being hydroscopic, must be tightly corked, so as to
avoid being deteriorated by the moisture contained in the atmos-
phere.
Although glycozone absorbs water readily, it does not deteriorate
when kept at a temperature of no degrees F as long as it retains its
proper anhydrous condition.
The therapeutic properties of glycozone and Marchand's peroxide
of hydrogen (medicinal) differ in the following particulars:
Peroxide of hydrogen (medicinal) instantly destroys the morbid ele-
ments of diseased surfaces of the skin or of the mucous membrane
with which it comes in contact, leaving the tissues beneath, in a
healthy condition.
On the contrary, glycozone acts more slowly, but not less certain
as a stimulant to healthy granulations. Its healing action upon dis-
eased mucous membrane is powerful and harmless in the treatment
of inflammatory diseases of the stomach. In such cases it gives an
immediate relief to the patient. (See Dyspepsia, page 27.)
In chronic inflammation of the intestines, a rectal injection admin-
istered every day with a mixture composed of
S Glycozone, = r
Lukewarm water, 3 12
soon relieves obstinate conditions.
A syringe made exclusively of hard rubber or glass, should be
used in all instances where either peroxide of hydrogen (medicinal),
or glycozone is used as an enema.
After any diseased or suppurating surface has been cleansed bf
peroxide of hydrogen (medicinal), the application of gh'cozone stim-
ulates healthy action, and accelerates a cure.
^
47
General Directions for Use. — Glycozone may be given for dis-
eases of the stomach, in doses of one to two teaspoonfuls in a wine-
glassful of water immediately after each meal. In catarrhal diseases,
it should be applied in full strength as often as required.
As an application to wounds and suppurating surfaces it should be
used without dilution. For further directions see information under
the different diseases mentioned in this pamphlet.
Caution. — Glycozone is a peculiar chemical compound, and not a
mixture of peroxide of hydrogen (medicinal) with glycerine.
These two liquids when mixed do not form a stable product, but
develop substances which have injurious effects upon animal cells.
Such a mixture when freshly made, has no healing properties simi-
lar to glycozone. On the contrary glycozone is stable, harmless and
always effective.
OPINION OF THE MEDICAL PROFESSION.
See a report on Hydrogen Peronide, rend at Ihe Indiana Inslitule of Honuc-
opatby, May 19, iSSs, published in the Medical Era, July. 1885, and republished in
response to numerous requests, after having been revised, in the number isiiued Apiil,
1886. By Wm. B. Ckike, M.D,, Indianapolis, Ind.
In tbia very elaborate article Dr. Wm. B. Clarke says : " I have used several
makes of Peroxide of Hydiogen, forei^ and domestic, and find the purest and best
to be Ch. Marchand's Peroxide of Hydrogen (medicinal),"
See also a report on Hydrogen Peroxide read before the New York Societj' for
Medico-Scientiiic Investigation, by W. W. Blackraan, M.D., Brooklyn, N. V. '""
report is published in the North American Journal ef Hammopathy, July, 18S6,
554 to 5^-
^
SOME CLINICAL FEATURES OF DIPHTHERIA AND THE
TREATMENT BY PEROXIDE OF HYDROGEN.
Bv GEORGE B, HOPE, M.D„ New Yobk.
Surgion Milropolitan Throat Hospital; Professor Disrases of Throat, l/niva
of Vermont
(Extract from the Nrw York Mfdital Record, October 13. 1S88.)
I lung divided, with regard to the constitutional 01 1
seems to be now almost universal in the direction of the Utter
in the light of this opinion, it is clear that the rational
re on the recognition of some local agent which will surely
destroy the specific germ before a full development of the constitutional iofection is
reached, ratber than on any system of general medication which might be presUiDtd
to set more or less as an antidote in combatting the septic influences occurring in ths
course of Ihe disease
On account of their poisonous or irritant mtture, the active germicides have.
utility limited piirticularly to surface or open-wound applications, and their tree nw il
reaching diphlieritic fomtations in Ihe mouth or throat, particularly in children, i
unfortunately not within the range of systematic treatment. In Peroxide of
Hydrogen, however, it is confidently believed will be found, if not a specific, at Icist
the most efficient topical agent in destroying the contagions element and limiting the
spread of its formation, and dt Ihe same time a remedy which may be employed iti ihc
most thorough manner without dread of producing any vicious constitutional effect.
Although tbe Peroxide is by no means of recent dale, its medicinal value has been
chiefly confined to the cleansing of foul ulcers and suppurating wounds, and (here is
hardly more than a easual mention of its utility in the treatment of diphlheiii
previous to a paper of Dr. Mount Uleyer on this subject.* Quite independently of
these observations, somewhat over eighteen months since, at the Metropolitan Thrutt
Hospital, several cases of well-marked buccal diphtheria were treated with the
*TktMiiiicalRlisTd,kxiixaXi-i, ifil?.
49
Peroxide, with the effect of confirming in the most Ba.tisfactoiy manner the results
obtained by Dr. Bleyer. The report of these cases Has consequently omitled,
pending the ei:peiiences it was supposed others would be quick to funiish on a more
extended scale of the new remedy so warmly advocated. Among the Eomewhat small
number of trial cases which have appeared at various limes in the medical press, there
are none in which a distinctly negative opinion is expressed, and where only a partially
satisfactory result is attained there has appeared to be sufficient cause Co permit a
reasonable explanation for the fact
A further explanation for the uncertain results attending the use of the Peroxide
lies in the direction of the preparation itself, as also in the manner of its topical
application. The usual descriptions allow the diluted strength of from three to seven
volumes of distilled water. Inasmuch as the efficacy depends upon the ozonized
oxygen in solution, it has seemed desirable to rely on the full strenglb of the officinal
preparation of fifteen volumes, especially when uaed in the fauces, where any slight
irritation from its acidity is not apparent. In all the cases treated, a fresh, standard
Marchand's preparation of fifteen volames vina that on which the experience of the
writer has been based. An equally important element is in making the application in
such a manner as to produce the most determined effect on the diseased tissues with
as little local disturbance as possible. Swabbing the tonsils and pharynx is the rough
and ready method commonly resorted to, with the second motive of detaching, if
possible, the membranous formation. Such treatment is not only unnecessarUy
harsb toward the patient, but also in intrinsic efficacy falls far short in securing the
best therapeutic value of the remedy. It is properly recognized that the removal of
the membrane, unless it occurs spontaneously, is not favorable to the local conditions ;
moreover, the glaity mucus coating the surface does not permit the application to
come fairly in contact with the disease, or so superficially as to require the most
constant repetition. The latter criticism holds the same bearing, only modified in a
degree, to the hand-ball vapor and spray-producing instraments that have been
A steady, coarse spray, with aji air-pressure of twenty pounds or more, will in a
few moments' time produce a more positive action than prolonged efforts to reach the
fauces by means of cotton applicators. The force of the spray should be sufficient In
cleanse at once the surface accumulations, as it destroys the necrosial elements with
which it comes in contact. In this manner the removal of IheJfiris and the actinn on
(he deeper structure eo hand in hand.
It will be noticed that immediately on contact with the Peroxide, a white, cloudy
coagulum is formed on and about the diphtheritic patches, readily floated off and
exposing a more sharply defined and a flatter, smooth and whiter base. Properly
speaking, there is no liquefaction of the exudation, but the decomposition of the
inJiamroatory products is so complete that the Cells are broken up and freed from the
entangling fibrous net-work beneath. In a particular instance, in the case of
apparently a continuous diphtheritic slough, involving the tonsils and eniending in an
unbroken line across the margin of the soft palate, a solitary application exhibited
(his effect to such a degree that the natural color of the mucona membrane appeared
in spots as if the exudation might have bridged across sound tissue without as yet
secnring attachment to the sub-epithelial layers.
How frequently the treatment is to be followed up depends to a considerable
extent on the density as well as the area of the surface involved. It may be said,
however, that two applications a day, in the great majority of cases, should be
sufficient, if thoroughly performed, to arrest all danger of extension and accomplish
■he gradual resolution of the local formation.
Ttf Ihe experience of the writer is confirmed, it ii apparent how much time,
trouble and unnecessary handling is obviated when contrasted with the methods
ontlining hourly or half-hourly swabbing, or, a? one baa more frankly expressed it,
"scrubbing," with nauseatiiig applications, and culminating in the exhaustion of the
patient, if not the most indifferent success. No reasonable objection can be raised
so
either on [he 5core of (he expense or the difficulty of transporting the apparatns
necessary, as small portable ai [-receivers can be readily obtained in the itistntmrat
shops, on the model of those devised by Codman & ShurileR, of Bo5tOn, and which
for the purpose ate equally efficient as the larger stationary office fixtures.
The more recent experience oi Dr, tlifford (the Medical Jficarii, September I,
1888), establishing the active germicidal properties of Peroxide of Hytlrogen, rapidly
diminishing in proportion (o its dilution in what might be called a geometrical rBlio.
appears to emphasize in a marked degree the clinical observations on which the mun
Matures relating to its employment have been based.
OME PRACTICAL HINTS IN CONNECTION WITH INTU-
BATION OF THE LARYNX, AND A RESUME OF 206
CASES OF DIPHTHERIA OPERATED ON FROM t886
TO i83S.
Bv /. MOUNT BLEYEk, M,U.
■>>!(■ yark MedicaiJpur«al,Yibi<ia.ty2 1888.
(lixtracl.)
. . , JmgalioH. — This is an admirable method of uashing away the
products of the local lesion. 1 use a No. 8 soft-rubber catheter which is attached to ■
fonnlain-bag syringe ; the catheter is passed into the nosliilB, first the right and then
the left. The solution which is used is made by taking Peroxide of Hydrcgen
(Charles \tarchand's), fifteen volume solution, chemically pure, one ounce to twelve
ounces of water. With this solution irrigate each nostril thoroughly. After this ha*
been done, (he next move is to wash out the mouth, phaiyns;, and larynx. If the
child can he managed without forcing the month open, there is no need of the
insertion of a gag ; but if not use it. 'The patient is to be held well forward overs
basin for the reception of the reluming fluid. Make a second mixture of the Peroxide
of Hydn^en of the strength of four drachms to twelve ounces of water. The catheter
is passed well down into the larynx, the surrounding parts, and thoroughly irrigated.
The fluids are very seldom swallowed, and if this fluid mixture should be swalTowed
there is no danger of poisoning, as It is a perfectly harmless antiseptic. The fltlid is
genendly immediately expelled by coughing. The mouth is to be kept wide open ud
the head well forward. By this mode of treatment patches of membrane, inspissated
muco-pus, etc., can be washed away without difficulty and without pain. My
experience with Peroxide of Hydrogen for the last four years has made me famiUu
with its varied use in the treatment of diseases of the nose and throat, FtT>mi
consideration of the action of Peroxide of Hydrogen upon the deposit of diphtheritic
membranes, and the rapid reproduction of bacteria, it will at once be evident that Ae
earlier the application of the remedy is adopted, the better. While the membrane is
thin and friable, the action of this agent is thorough, quick, and effective ; the d«poat
melts down before the contact of it like sugar in water, to be reproduced in a ^Mlt
time and again removed until the diseased tissue beneath can be plainly seen ttet
from this characteristic covering. In this way, also, the spread of the memtwaiieii
checked and its limils often sharply circumscribed, until after some days, when die
germinating power of the membrane is conquered and the poison ccB-ses to prodnce !t»
kind, no more deposit takes place, and the diseased tissues heal. In view of the i«|rid
reproduction of bacteria already mentioned, it is evident that the applications thonld
longer apart than two hours, or even less, according 10 the rapid reprodnttiap
of the membranes. Gargling may be practiced by those who are able, but irrigation
is preEerted, as a more thorouch application is thereby made. Irrigation is easily
leamed by the nurse, and there is absolutely no danger connected with its use. . .
For inteiiial use I give the preference to Glycozone, which is chemically pure
glycerine saturated with active ozone. It is to be used locally, as a substitute for
bichloride of mercury, carbolic acid, permanganate of potash. This is the most
powerful of all organic disinfectants and bactericides. I give lo a child over two years
o£ age half a teaspoonful of Glycoione, well diluted with water or milk, every two
lo tour hours, and under that age twenty drops. . . .
ON THE MEDICINAL USES OF HYDROGEN PEROXIDE.
By E. R. SQUIBB, M.D., Brooklyn.
Read before the Kings County Medical Association, February 5, 18B9, during the
discussion on diphtheiia, and published in Gaillard's MtdUal Joutnal fnr
March, 18B9, p. 267.
Throughout the discussion upon diphtheria very little has been said of the use of
the Peroxide of Hydrogen, or hydrogen dioxide, yet it is perhaps the most powerful of
all disinfectants and antiseptics, acting both chemically and mechanically upon all
excretions and secretions, so as to thoroughly change their character and reactions
instantly. The few physicians who have used it in such diseases as diphtheria,
scarlatina, small-pox, and upon all diseased surfaces, whether of skin or mucous
membrane, have uniformly spoken well of it so far as this writer knows, and perhaps
the reason why it is not more used is that it is so little known and its nature and action
so little understood. Until within the last few years, except in a few manufacturing
processes, it was chieHy known as a chemical curiosity, rarely seen because difficult to
In order to use it intelligently both the pharmacist and the physician must know
something of its nature and properties. The name hydri^en dioxide expresses its
composition, and its formula. Hi Oi represents this name. Hydrt^en monoxide, Hg O,
or water, can under certain conditions be made to combine with a second molecule of
oxygen, the result being a water-like liquid, Hj Oj,
This second atom of oxygen is very loosely combined, and the compound molecule
is always on a strain lo break up into water and osygen, and when it breaks up, cither
slowly or rapidly, the oxyeen separates in that nascent or most active and potent of its
conditions next to the condition known as ozone. It is in the change of this breaking
up into water and active oxygen that the latter clement exerts its power, and the
mmple contact with oi^anic matters, which are themselves of complex nature and in
condition to be changed, is sufficient to break up the dioxide and liberate the active
oxygen. For example, some albuminoids are instantly changed by contact with
Iwdrwen dioxide, as is shown by rinsing the month with a dilute solution, when the
afbunimoid matters of the secretions are at once coagulated. Then, as all virus is
albuminoid, whether propagative or not, it is destroyed, or by coagulation rendered
inert by simple contact with Ibis agent, just as it is by contact with corrosive
sublimate. This simple experiment of rinsing the mouth with a dilute solution of
hydrogen dioxide and examining the discharged liquid can hardly fail to convince any
one of the destructive potency of this active oxygen on some albuminoids, and of its
thoroughly cleansing effects upon the mucous surfaces.
Now, if diphtheria be at first a local disease, and be aato- infectious — that is, if it
be prop^ated (o the general organism by a contagions virus located about the tonsils,
and if this virus, be as it really is, an albuminoid substance, it mi-i asA -m^ >»e
i sufficienlly repeated conlact. . . .
^ , J . .. now be easily obtained witli fittings of
hard rubber or glass, and such only should be used,
A child's nostrils, pharynx, and mouth may be flooded every two or three hours, or
oflener, from a proper spray apparatus with a two-volnme solution without force, and
with very little discomfort ; and any solution which iinds its way into the larynx or
stomach is beneficial rather than harmful, and thus the effect of corrosive sublimate is
obtained without its risks or dangers. Adults and children aid enough to gargle the
pharynx and rinse Ihe mouth will get a better efFect in this way, equally without much
discomfort, from a three-volume solution ; and this applies not only to diphtheria, but
lo scarlatina and other conditions of the mouth and throat which require cleansing and
disinfecting. As vaginal injections in cases of uterine cancer, etc, , the strength must
be increased until the disinfectant effect is obtained. A copious Hnshing out with a
one-Tolume solution will often be sufficient. When wetted cloths are luiil over eilemal
sores an over-covering o£ oiled silk should be used.
As, in passing through several hands after leaving those of the maker, b little
mismanagement may spoil the solution, some easily applicable tests of quality and
strength are needed.
So long as the solution will yield any active ox^en at all, it will give this off with
active effervescence when poured onto a crystal or two of potassium permanganate,
A solution containing only a quarter of its volume will give an effervescence so strong
as to be misleading, and therefore a quantitative test is needed. The following is a
modification of a testing process given to the writer, with much other useful informatioo
by Mr, Charles Marchand, of No. lo West 4lh Street, New York City, one of the
oldest and best makers of Peroxide oC Hydrogen, and one who supplies it to all parts
of the country. , . .
IE this agent is to be generally used in the treatment of diphtheria, as it well
deserves to be on well established principles of action, it is very important that it be
freely applied in the earliest possible stages of the disease, or while it is yet lc»cal; and
therefore Ihe agent should be easily and promptly accessible in places known to physi-
cians, and not over a mile apart throughout a city, and in hands which know the agent
well, and know how to keep 11 from change and to dispense it on physicians' orders,
If all pharmacists should undertake to keep it — or even all the prominent ones —
it would soon share the fate of many other important medicines. . ,
PEROXIDE OF HYDROGEN FOR GONORRHfEA,
REPORT OF DR, E. ClIAREST.
{Afedical tVorid. Philadelphia, Pa,, June, 1RB9.)
Editor Medical World:
1 intended for some time to give to the 1
treatment for gonorrhoea and gleet, and I
Stroud's offer to do so now.
What I consider the simplest, quickest and least harmful treatment of gonorriiaa
is Peroxide of Hydrogen in injection A j to Ihe \ of distilled water, three to five tima
a day.
Inlernally ten to fifteen grains of soda: bicarb., every three hours, lo keep the
urine alkaline.
The Peroxide of Hydrogen is used a good deal in cotiimetce for blecching pui^
poseF, 50 that there aie dilfeient qualities of it on the market.
Foe medical use it must be neutral to the litmus paper, odorless and colorless.*
This kind you may have from C. Marcliaud, loWest Fourth Street, New Vork City. It
must be kept at a temperature below 65° F., and no metal must come in contact with it.
In writing to the above-named tirm you will receive a pamphlet on this valuable
remedy well worthy to be studied,
I consider it the best germicide, as it is the least harmful and the most effective.
For the paiit two weeks 1 have used it !□ the form of a spray, in one of the worst
cases of eczema, of four years' standing, which had so far resisted the assaults of a
dozen doctors backed up by as man)' drug stores, and is now almost well.
For syphilitic ulcers, soft chancres, diphtheria, ulcerated cervix, in fact, whenever
there ispus or gems, this is the true remedy.
In gonorrhcea, when the penis is highly inflamed, use (he injection four to five
tiroes a day and the inflammation uill rapidly be subdued, leaving the urethra in a
perfectly healthy condition. The use oE a suspensory is a great relief to the patient.
The fl. est. of black willow is very good lor the erections.
It is also the \aaeAy par cxccllcmr in gleet, and there is nothing like its inhalation
to cut short a paroxysm of asthma.
I don't claim the Peroxide of Hydrogen (Ha O5I to cute gonorrhcea in' three or
eight days, for 1 don't believe there is anything that wQl do so without danger; but it
will cure it in three weeks aud leave the unfortunate in the best of condition.
R. Charkst, M.D.
• MEDICINAL USE OF HYDROGEN PEROXIDE.
(Editorial New York Medical Record:)
It la with pleasure that we peruse the new issue of Sguiib'i Efhcntfris for July,
1889, confident as we are that whatever it tells us is in accord with the latest scientific
advances, and is the result of careful thought and research. Among its articles is one
Iw E. R. Squibb, on " Hydrogen Peroxide" (published also in Gail/ard's Mfdieal
Journal, March, iSSg), I'his substance which is one of the most powerful and at the
same time the least harmful of all antiseptics and disinfectants, has never come into
general ose, probably becaose it is so unhandy and spoils so readily (Dr. Squibb thinks
It is because it is so little known and so little understood). It is made in large quanti-
ties by several large firms, but is used chiefly In the preparation of secret remedies.
Its properties have been known for a long lime. It is a compound of hydrogen and
oxygen which is easily decomposed, yielding water and nascent oxygen which quickly
oxidiies substance with which it is in contact. The mere amilicalion of a solution of
Peroxide of Hydrogen to certain albuminofd substances is sufficient to liberate its oxy-
gen, which immediately coagulates the albuminoid subslaace within its reach. Thus
all sorts of virus, whether propagative or not, are destroyed, or by coagulation rendered
inert in its presence, just as wheu strong corrosive sublimate solutions are applied to
them. The undiluted liquid peroxide is from its nature very unstable, and on slight dis-
turbance breaks up into water and oxygen with almost explosive rapidity. Therefore it
■■never made nor used nndiluted, but is always dissolved in water. The "Peroxide of
Hydrogen " which is furnished to the physician is really a solution of the pure liquid
in water to which a little hydrochloric acid has been added, the acid being necessary to
prevent rapid decomposition of the peroKide. A solution which will yield its own
volume of active (nascent) oxygen is called a one-volume solution. The fifteen-volume
•olntion (yielding fifteen times its volume of nascent ox^en) is that which is generally
supplied by the makeis. It is put up in pint battles, containing about (ifteen fluid
ouncCE, sold at $g a dozen. It is colorless and nearly odorless, tastes slightly acid,
and leaves a slight fleeting, not unpleasant after-impression. Changes in this solution
are indicated by the formation o[ bubbles of gas, which rise through (he liquid o,
adhere to the sides of the battle, and also by increased pre^isure within the bottles.
At ot below sq'' F., the solution does not change for a long time. At 63° F., it dots
change, sometimes very rapidly, giving off oiygen gas. The solutions, whether strong
or dilute, should be kept cool, onlside of the window of the sick-room in winter, and
on ice or in ice- water in summer. The bottles in which the solutions are contained
must not be held in the hand for any considerable time, as its warmth will cause
decomposition. It must not be kept in contact with metals, nor applied by means ol
melal apparalna, as it not only ruins the instruments, but forms poisonous salts from
the metu. It does not attack hard rubber or glass. It is not necessary to apply it ti
strong as when il comes from the maker. The ordinary fifteen-volume solution sold
is not injurious, but it is stronger than necessary, and to use it undiluted is wastefni.
For the irrigation of a child's nostrils, phurynx, and moalb, a two-volume (made hy
adding two ounces of the fifteen volume solution lo a pint of water solution, may be
used every two or three hours, and any part of this solution passing into the stomach
will do good rather than harm.
Aduits and children who can gargle — especially in scarlatina and diphtheiia — amj
use. as a gargle and mouth-wash, a three-volume solution (three ounces of tifteen-
volume solution to a pint of water). For vaginal injections, as in cancer, etc., a
thorough washing with the one-volume solution will often sufhce, but it may be neces-
sary to increase the strength until the desired effect is produced. When cloths wetted
in a solution are laid upon external sores they should be covered with oiled silk. The
methods for testing the activity of any solution are given in full, but need not be
repeated here. Mr. Charles Marcband, of No, lo West Fourth Street, New York
City, is referred to as one of the best maters and furnishers ot hydrogen peroxide.
It IS very necessary to get a good article, as cureless preparation and after-hand line
may render it inactive. It is desirable that it should be applied very early when used
i!_i..i — !_ i_r — .L_ J :^_ -^ |[jj. idroai have caused disease of ihe adjacent
PEROXIDE OF HYDROGEN FOR THE RELIEF OF BITES
FROM VENOMOUS INSECTS.
(Page 148, J^tu- Vork Medical Rfcord, February S. 1890.)
Br, Philippe Ricord, of Newark, N. J., writes:
" Recently, while chat^ng my atomizer with the full strength uf fresh ataodari
Marchand's preparation of Peroxide of Hydrogen, at the bedside of a child saBeriHC
with diphtheria, my attention was attracted by the patient's mother, who appeared I*
n the folds she had touched. Thereupon I immediately directed the
of Hydrogen spray into the wound, the surrounding tissues, in the few secondi Ibtf
had elapsed, being swollen to such an eKlenl as to distinctly mark its site. IiulMldy
all pain ceased, and the swelling rapidly disappeared. In this case the wound WM
stiU sufficiently open to readily admit Ihe Peroxide of Hydrogen, ami the dentnuaJMl
of the virus was apparently in a moment sj completely accomplished that no (iirthct
treatment was afterwards required. May we not, Iherefore. infer that it \t quitn
possible to annihilate many other poisons, likewise, by the prompt applicktion of XI
powerful yet safe on agent as the Peroxide of Hydrogen?"
THE NECESSARY PEROXIDE OF HYDROGEN.
Read in ihe Seclion tif Surgery anil Anatomy, at Ihe Forty-first Annual Meeting ot
the Ameiican Medical Association, held at Nashville, Tenn., Mav, 1S90.
By ROBERT T. MOR.RIS, M.D., or New York.
Publishcl by \\\s Journal fff the American Medical AsSQcialsen, Cliicago, Angust glh»
1890, page 216.
Slop suppuration 1 That is the duty that Is imposed upon us uheii we (ail to pre-
vcni suppuration.
As the ferret hunts the ral, so does Peroxide of Hydrogen follow pus to its narrowest
hiding place, and the pyogenic and the other mi cio -organ isms are as dead as the rat
that the ferret catches when the Peroxide is through with them. Peroxide of Hydro-
gen, HiO], in the strong 15 -volume siilutlon, is almost as harmless as water; and yet,
according to the testimony of Gifford, it kills anthrax spores in a few minutes.
For preventing suppuration we have bichloride of mercury, hydronaphlol, carbolic
acid, and many other antiseptics 1 but for stopping it abraplly, and for sterilizing a.
suppurating wound, we hare only one antiseptic that is generally efficient, so far as I
know, and that is the strong Peroxide of Hydrogen.
Therefore 1 have qualified it, not as "^flO^,"nol as "useful," but as " nicusary."
In abscess of the brain, where we could not thoroughly wash the pus out of tortuous.
canals without injuring the tissues, the H^Oj injected at a superficial point will follow
the pus, and throw it out, too/in a foaming mixture. It is best to inject a small quan-
tity, wait until foaming ceases, and repeat injections until the last one fails to bubble.
Then we know that the pus cavity is chemically clean, as far as live microbes are
concerned.
In appendicitis, we can open the abscess, inject Peroxide of Hydrogen, and so
thomu^y steriliie the pus cavity thai we ne«l not fear infection of Ihe general peri-
toneal cavity, if we wish to separate intestinal adhesions and remove the appendix
vermiformis. Many a patient, who is now dead, could have been saved if Peroxide of
Hydrogen had been used when he had appendicitis.
The single means at oui disposal allows us to open the most extensive abscess psoaz
without dread of septic infection following.
In some cases of purulent conjunctivitis, we can build a little wall of wax about
the eye, destroy all pus with Peroxide of Hydrogen, and cut the suppuration short.
Give the patient ether, if the HiOg causes too much smarting- It is only iu the eye,
in Ihe nose and in Ihe urethra that Peroxide of Hydrt^en will need to be preceded by
cocaine (or ether) for the purpose of quieting the smarting, for it is elsewhere almost
as bland as water.
It is possible to open a large abscess of the breast, wash it out with HiOi, and
have recovery ensue under one antiseptic dressing, without the formation of another
drop of pus.
Where cellular tissues arc breaking down, and in old sinuses, we are obliged to
make repented applications of the HiOi for many days, and in such cases X usually
follow it with baJsam of Peru, for balsam of Pern, either in fluid form or used with
ctcrtliKcd oalcun:, is a most prompt encourager of granulation-
If we apply HjOj on a probang to diphtheritic membranes at intervals of a few
they swell up like whipped cream and come away easily, leaving a clean
The fluid can be snulfed up into the noee and will render a fcelid ozoena.
innecessary for me to speak of fartbei indications for its use, because whei-
: is pus we should use Peroxide of Hydrogen. We a.re a1! familiar with the
old law "UiifiMi, ibi evactia," and I would change it to read " UH fus. Hi evama,
ibi kydrogemim pfroxidum infunde." That is the rule The exceptions which prove
the rule ate easily appreciated when we have them to deal with.
Peroxide of Hydn^en is an unstable compound, and becomes weaker as oxygen a
given off, but Marcband's 15-voluine solution will retain active eennicidal
power for many months if kept tightlj corlced in a cold place. The price ol
this manufactorer's preparation is about 75c per lb., and it can be obtained from any
large drug house in this country. When using the H^Oi it should not be allowed 10
come into contact with metals if we wish lo preserve its strength, as oitygen is then
given off too rapidly.
H5O1 must be used with caulion about Ihe hair, if the color of the hair is a matter
of importance lo the patient : for this drug, under an alias, is the goldeti hair bleach
of the nymph's despare. and a dark-haired man with a canary-colored moustache i* A
Stirling object,
PEROXIDE OF HYDROGEN AND OZONE.
THEIR ANTISEPTIC PROPERTIES.
Kead before the International Medical Congress, held at Berlin, Germany, on the 7th
of August, 1890. Published by Mrdical Neva of Philadelphia, October asfli,
1890. Pp. 416-413.
By Dr. PAUL C.IBIER, Dirt.-tor of Ihr Pasltur' ImliUO/ of Xi-w Yiiyl:
Ge!stle«en :
Since the discovery of Peroxide of Hydrt^en by Thcnard, in 1818, the therapeut-
ical applications of this oxygenated compound seem lo have been neglected bnlh by the
medical and the surgical professions ; and it is only in the last twenty years that a few
bacteriologists have demonstrated the germicidal potency of ibis chemical.
Among the most elaborate reports on the use of Ibis compound may be mentioned
those of Paul Bert and Regnard, Baldy, Pean and Larrive.
Dr. Ktiguel places Peroxide of Hydrogen ai the head of a long list of antiseptiOh
and close lo the silver salts.
Di. Bouchut has demonstrated the antiseptic action of Peroxide of Hydn)|;eil,
when applied to diphtheritic exudations,
Prof Nocart, of Atfort, attenuates the virulence of ihe mictobe symptomatic of
carbuncle, before he destroys it, by using the same antiseptic.
Dr. E. R. Squibb.' of Brooklyn, has al«o reported the satisfactory resalts wtikJl
he obtained with Peroxide of Hydrogen in Ihe treatment of infectious diseases,
Allhough the above-mentioned scientists have demonstrated by their experunenlB
that Peroxide of Hydrogen is one ot the most powerful destroyers of pBlhogenie
microbes, lis use in therapeutics has not been as extensive as it deserves to be.
In my opinion the reason for lis nol being in nniTCrMl nse is Ihe difficulty o(
procuiing it free from hurtful impurities. Another objection is the utislableness of the
compound, which gives off" nasceni ox}^en «hen brought in contact with OigsBk
Besides Ihe foregoing objections the surgical instruments decompose the peroxide,
hence, if an operation is to be performed, the suigeon uses some other nnliseptic during
the procedure, and is apt to continue the application of the same antiseptic in the sub-
sequent dressings.
Nevertheless, the satisfactory results which I have obtained at the Pasteur Insti-
tute of New York with Peroxide nf Hydrogen, in the treatment of wounds result-
ing from deep bites, and those which 1 have observed at the French clinic o*.
New York, in the treatraenl of phagedenic chancres, varicose ulcers, parasitic
diseases of the skin, and also in the treatment of other affections caused by germs,
justify me in adding my statement as to the value o( the drug.
But, it is not from a clinical standpoint that I now direct attention to the anti-
septic value of Peroxide of Hydrccen. What I now wish is merely to give a full
report of the experiments whicj) I have made on the effects of Peroxide of Hydrogen
upon cultures of Ihe following species of pathogenic microbes; Bacillus anthracis,
bacillus pyocyaneous, the bacilli of typhoid (ever, of Asiatic cholera, and of yellow
fever, streptococcus pyq^nes, micro-bacillus prodigiosus, bacillus megalerium, and
the bacillus of osteomyelitis.
The Peroxide of Hydrogen which 1 used was a 2-3i solution, yielding fifteeo
limes its volume of Oxygen ; but this strength was reduced to aliout 1.5S, correspond-
ing to about eight volumes of Oxygen, by adding the fresh culture containing the
microbe upon which I was experiment! tig. I have also experimented upon old cultures
loaded with a large number of the spores of the bacillus anthracis. In al! caser
my experiments were made with a few cubir centimetres of cnlluce in sterilized test-
tubes, in order lo obtain accurate results.
The destructive action of Peroxide of Hydrogen, even diluted in the above pro-
portions, is almost instantaneous. After a contact of a few minutes, I have tried to
cultivate the microbes which were submitted to the peroxide, but unsuccessfully,
owing to the fact that the germs had been completely destroyed.
My next experiments were made on the hydrophobic virus in the following
I mixed with sterilized water a small quantity of the medulla taken from a rabbit
that had died of hydrophobia, and lo this mixture added a small quantity of Peroxide
of Hydrogen. Abundant effervescence took place, and, as soon as it ceased, having
previously trephined a rabbit, I injected a large dose of the mixture under the dura
mater. Slight effervescence immediately took place and tasted a few moments,
but the animal was not more disturbed than when an injection of the ordinary virus
is given. This rabbit is still alive, two months after the inoculation.
A second rabbit was inoculated with the same hvdrophobic virus which had not
been submitted to the action of the peroxide, and this animal died at the expiration
of the eleventh day with Ihe symptoms of hydrophobia.
1 am now experimenting in the same manner upon the bacillus tuberculosis,
and if I am not deceived in my expectation, I will be able lo impart to the profession
some interesting results.
It is worthy of notice thai water chatted, under pressure, with fifteen limes its
volume of pure oxygen has not the antiseptic properties of Peroxide of Hydrt^en.
This is dne lo the fact that when the peroxide is decomposed nascent oxygen
separates in that most active and potent of its conditions next to the condition,
orallotropic form, known as " Oione." Therefore it is not illogical to eonclnde that
ozone is the active element of Peroxide of Hydrogen.
Although Peroxide of Hydrogen decomposes rapidly in Ihe presence of organic
sabslances, I have observed that its decomposition is checked to some extent by the
■ddition of a sufficient quantity of glycerin ; such a mixture, however, cannot be kept
>, and megaterian
(or a long time, owing to the slo\
having irrilnting properties.
Before concluding I wish to call
rather oionized compound, which has h
by Mr. Marchand.
This Glycoione re'ialts from the
exposed to the action of oione under j
volumes of ozone produces Glycoione.
By submitting the bacillus anlhracis, pyocyaneous, prodigi
to the action of Glycorone, they were almost immediately destroyed.
I have observed that the action of Glycozone upon the typhoid fever bacillus, Hnd
some other germs, is much slower than the influence of Peroxide of Hydrogen.
In the dressing of wounds, ulcers, etc., the antiseptic influence of Glyccuone is
rather slow if compared with that of Peroxide of flydrogen, with which it may,
however, be mixed at the time of using.
It has been demonstialed in Pasteur's laboratory that glycerine has no appreciable
antiseptic inlluence upon the virus of hydrophobia; therefore, I mixed [he virus ol
hydrophobia with glycerine, and at the expiration of several weeks all the animals
which 1 inoculated with this mixture died with the symptoms of hydrophobia.
On the contrary, when glycerine has been combined with osone lo form Glyco-
zone, the compound destroys the hydrophobic virus almost instant aneousty.
Two months ago, a rabbit was inoculated with the hydrophobic vims, which hai
been submitted to the action of this new compound, and the animal is still alive.
I believe that the practitioner will meet with very satisfactory results with the uie
of Peroxide of Hydrogen for the following
This chemical si
LO injur
a very energetic destructive
no toxic properties ; five cut
I not produce any serious result,
effect upon animal cells.
upon vegetable cells— microbe*.
injected beneath the skin of
Iso harmless when given by
As an immediate conclusion resulting from my experiments, my opinion is, that
Pcioxide of Hydrogen should be used in the treatment of diseases caused by gemu,
if the micrubian element is directly accessibEe ; and it is particularly useful Id ibe
treatment of infectious diseases ol (he throat and mouth.
HYDROGEN PEROXIDE IN DIPHTHERIA.
Extiac: irom the vVVa; York MeJiralJeumal, December 6, 18^0,)
1189 itAUisuN AvtNi;E, Maitmitr S, iSgo.
To THE Editor of the A™ Vork Medical Journal .•
Sir : — I would suggest the following local treatment for diphtheria r TheappKci'
tion to the membrane of Marchand's solution of Peroxide of Hydrc^en, fifteen volumes,
with an equal bulk of water, then scraping the membrane olT with a curette and apfdy-
ing the Peroxide of Hydrccen, one-third dilution, every hour for six or seven houn,
then every two hours If there is no reappearance of membrane after two days, spnj
the throat occasionally with an antiseptic spray. In this way the membran* M
Tenioved mt once. The operation is done at a period of the disease when there is no
danger of heart failure, so that the struggles of a child need not be minded.
I am aware that the removal of the membrane in former years was regarded as
somewhat dangerous, but at that time nothing was known of disinfectants and germl-
It would seem that a remedy which, applied to the diphtheritic membrane,
removed it after some hour^, would prevent its formation. In tolerant patients the
peroxide may be put on three or fotir times so as to be sure of complete disinfection
before curetting. A small Thomas's uterine curette answers the purpose admirably.
A patient treated as described was comparatively well in two days.
David Phillips, M.D.
PEROXIDE OF HYDROGEN.
(Extract from Medical Summary, December, 1890. Page 214.)
After trying for the past five years innumerable therapeutic agents for my lapus
or epithelioma, 1 was advised by Dr. Cutter, a celebrated microscopist and scientist of
New York, to spray the ulcer with the peroxide and afterwards apply cotton saturated
with the same. I used three different local applications, aristol, Howe's salve, and
the peroxide ; marked the cotton and sent the same to him.
He reported the best results from the peroxide and advised its continnance.
Though it did not kill the spores it made them inactive, while no perceptible difference
could he seen upon them from the other two. This peroxide bore the initials P. & W. ,
our noted Philadelphia chemists. Seeing Marchand's advertisement in the StiMMARY,
I concluded to try his, and sent for some. He kindly included in the order his glyco-
lone to use in conjunction with the peroxide. A marked change was the result. The
sore looked better, cleaner, healthier, and upon examination of the cotton. Dr. C
wrote me to continue the use of Marchand's. Here was a decided test and in favor of
Ch. Marchand's. The ulcer has steadily progressed for the better. • * • *
Yardlev, Pa.
. LtVEZEV, M.D.
HYDROGEN DIOXIDE; A RESUMfe.
By JOHN AULDE, M.D., of
fficfn StftdiCitt AraociiUiBr
<f State Iff /^muy/vaMi'm,
(Publighed by the ^rw York Medical Journal, December 37, 1
o.)
Within the past ten years the use of hydrogen dioxide (peroxide of hydrogen) has
become quite general among practitioners whose business has led them to give special
attention to some particular class of disorders. Many genera! practitioners, however,
have not availed themselves of the benefit afforded by this comparatively recent addition
to our therapeutic resources, owing to the expense and the care required in looking
after details, together with the uncertainly which attended its employment. The.se
difficulties no longer exist ; hut. when we consider the advantages to be gained from its
use, the process of evolution has been remarkably slow, notwilh standing the sporadic
attempts which have been made to allract the attention of the medical profession.
Novel methods of treatment are too frequently shunned without investigation by
regular physicians, while, on the contrary, these innovations are readily adapted 10
the wants of the quack.
In the present instance, although the furori for antiseptics continues unabated,
the true position of oxygen has been ignored by those who should have given it their
lirst attention. Long-continued and persistent effort has erected an impounj
superslmcCnre upon a theoretical foundation, losing sight of the marvelous inlluencet
constatilly at work in nature. The corner-stone of this ornate edifice originallr
adopted was carbolic acid ; the pilasters which gave strength and beauty to its walls
were composed of carbolaled game, while cornice and roof were made of protectiTe
which had been submitted to a carbolizing process. This highly flavored substance
has given place to a number of others, some of which are safer, but no more useful ;
others are more efKcient than carbolic acid, but, as usually employed, aie far more
dangerous. As the foundation for asepsis rests upon absolute cleanliness, so (he
foundation for antisepsis must rest upon an equally safe basis as regards the patient
The only agent known at (be piescnC lime which fully meets our requiremcDl*
oxygen in some of its forms. While the spores of anchrai bacilli resist our nuMt
poisonous products— such as solutions of hydrochloric acid (two pet cent.), boric and
salicylic acids in concentrated solutions — oxygenated water alone, in sufficient qaantilT,
was shown by Paul Bert and Regnard to possess the power of destroying the bacleni.
The wonderful properties of ozone are but partly understood ; like some other
powerful agents, it cannot be safely handled, but it gives great promise of usefullietl
in the future. The statement has been made that ozone is but an allotropic form o)
ox}^en, and that it is identical with hydri^^ dioxide (the subject of the present
article), and for all practical purposes, from a therapeutic alandpoinl. they may be
considered substantially the same, Having, then, at our command a remedy
possessing such remarkable properties as a bactericide, one which is perfectly harmlea
when brought into contact with healthy tissues, it wilt be worth while to stndyihe
indications for its use in the treatment of disease. In the first place, however, I
should say a word with reference to the causes which have contributed to prevent Us
universal employment by physicians — causes already referred to incidentally. • • "
3, The uncertainty {(Xiowm^ (he employment of the peroxide has arisen fran
various causes, and, as this is a subject of paramount importance, the items will be
considered in detail. In the pure state hydrogen peroxide is exceedingly unalabl^
and. in order to render it less susceptible to the action of heat, which causes it to part
with nascent oxygen rapidly, minute quantities of hydrochlotic and phosphoric acids are
added to the usual ii flee n- volume solution ; but this, instead of retarding, rather
heightens the effect of the remedy when applied to unhealthy structures, especiaDy
mucous surfaces. When the container is allowed to remain in a warm room, or when
it is not properly stoppered, the activity of the preparation is materially lessened, if
not entirely lost. An excess of acid is objectionable, however, as it rendert, die '
peroxide irritating instead of soothing.
GMflmffrcia/jWroirirfi which is used extensively for bleaching purposes and in (ha
arts, is doubtless responsible for unsatisfactory results, but, as compared with the
medicinal preparation, it is a very inferior product, sold at a cost of about eight cents
a pound. Physicians should know that this product always contains a large propDrdon
oi acids (two 10 live per cent.), hydrofluoric, sulphuric, hydrochloric, oxalic, and nitttc
acids, and, knowing this to be the case, they should l>e careful to eiamtDe the '
reactions and see thai the medicinal preparation obtained by patients is supplied fat < J
original packages. The commercial product is not "just as good" nor will it "daH J
weu" for the patient ; and if these suggestions are kept in view, the sncceat of Ae 1
peroxide is assured.
Another important thing which I have learned Is, that the mixture of the pen»d<
vilh glycerin does not make "glycozonc," but, instead, a rahcture which f '~~
6l
sWlf bat constantly eecondai; products, nhtch appear to possess irritating properties
almosi as toxic as those of formic acid, well known in Central Africa as a deadly
iriow poison. I am of the opinion also that when the peroxide is used in ihe form of
aniahalatioD hj heating with water, a considerable proporlion of the nascent oiygen is
trsnEformed into ordinary oxygen before reaching the affected tissues, and while I con
rudily understand how this must detract from its efficiency, reniar.kably prompt results
baTe attended its administration in this manner. The only obstacle in the way of
scaring immediate and favorable resalts from the exhibition of this agent is oui
inibilily to command at all times a freshly prepared and thoroughly reliable product,
/lee from (he impurities incident to its manufacture ; but that difficulty, I believe, is
no longer an eicuse, as it can be snpplied by the principal druggists throughout the
coantry. • * •
Tkiraptutics — From the peroxide of hydrogen we may obtain, in the form of a
vapor or spray, the therapeutic effects of nascent oxygen, and as a surgical application
01 antibacterial substance this product is far superior to the gas itself. Used in tbe
fomi of a vapor by inhalation, it increases ihe secondary assimilation by favoring Ihe
elimination of excremenlitious products through the stimulating effect upon internal
respiration. Just as pure mountain air arouses the activity of functions which have
been depressed and promotes health, so oxygen evolved in this manner increases tissue
ciiuigeand prevents the suboiidation which attends upon the arrest of cell function.
Oxygen is a tissoe builder as well as an oxidizer of carbonaceous and excreDientitious
products. When it is introduced into (he alimentary tract, abdominal fermentations
arc arrested by the destruction of the germs which produce them ; unhealthy mucous
" '' IS are destroyed, white the vitality of the cells lining the walls of the intestine
^ted, and their power against the absorption of ptomaines and leucomaines
greany increased. The surgeon will £nd the peroxide an efficient and most convenient
intiseptic, as it can tie freely used in cavities, in discharging sinuses, and upon the
~~(t delicate tissues, without danger of producing the slightest irritation. • In all
s of threatened collapse, io low cooditions of the system, and during convalescence
n severe illness, tbe physician should bear in mind the wonderful revitalizing
piDperties of this remedy. Perhaps the reader will gain a more practical idea of the
appiicalions by a reference to some of the more prominent indications, and I shall
bneRy pass in review some of the diseases in which it may be used with beneficial
Since it has been determined that ia yiUoiii fever and cholera the poison germ is
iound only ia the intestine, the peroxide promises to afford exceptional relief in these
When it is introdnced in(o the rectom, the beat of the body will cause
oxygen gas to be evolved, while the local action of the drug will destroy all unhealthy
jiioducls which may be present in the lower bowel. The nascent oxj^en will be taken
spby the absorbent structures and enter the general circulation ; but if we accept the
■tocttine of phagocytosis, it will do even more than this, by reason of its stimulating
1 upon the modified white corpuscles, which are now regarded as the special
ies of bacteria escaping through the walls of the intestines. And for the same
n it may be used with advantage as a lavement in the ircalment of diarrhaa,
dysentery, and in typhoid fever. In the latter disease I have used the pnre oxygen
£U vrith very great satisfaction, and have found a solution of the peroxide superior as
1 mouth wash during the progress of this most tedious disorder.
The peroxide should be used in all forms of indi^stion, and more especially when
e stomach is weak and depressed to such an extent that the usual antiseptics are not
;U tolerated. Those who use it once for the relief of indigestion, gastritis, gastralgia,
and for the arrest of fermentation, or an abnormal flow of mucous, will have no cause
Io regret the selection. A large nomberof cutaaeeus affections are dependent upon an
snhealthy condition of Ihe alimentary tract, such as urticaria, eczema, etc., and. of
'., ire benefited by the use of the peroxide.
i
Pulmrinaty afffcHms have long claimed the attention of those who dabbltd
with oxygen inhaialioDs, and it is id this class of cases wheie faithful attention to
details will produce most marked effects, although I can not be convinced that any
medicament in itself can arrest the progress of the disease. The continued use of the
peroxide internally improves Ibe primary assimilation ; the regular and systematic
mhalition of the vapor wilt not only improve the secondary assimilation, but will also
destroy any morbid products with which it comes into contact in the pulmonary liisnes,
and, judging from my own e^tperienee with this agent, I have no hesitancy in saying
that its value is not yet appreciated by a large number of pbysicians who, with it,
might be the means of prolonging human life. My observaticns with the vapor and
spray in asthmatic conditions have been surprismg, and I have found them of signal
service in meeting emergencies, such as asphyxia from coal gas, sudden collapse from
hemorrhage, typhoid and other fevers. The long continued use of Ibe vapor has >
marked effect m restoring the resiliency of the air-vesicles in emphysema when it
occurs along with asthma in young persons. A gentleman now under treatment hks
suffered from asthma since he was six weeks old, and is now iwenty-five, but under
this treatment he has gained weight, is able to sleep regularly every night, and hu
increased sixteen pounds in weight dnriag the past three weeks, while Uie chesi
measurement has appreciably decreased. This method of treatment is valoable it
phthisis at all stages, but it shonld be used as an adjuvant to other treatment and
attention given to diet. In this connection should be mentioned the usefulness of the
vapor in the treatment of hranchilis, subacute and chronic, and at the same time the
value in aborting attacks of acute catarrh.
Inhalations of the vnpor will prove useful as an adjuvant in neuralgia, amemie
headaches, general debility, malarial toxxmia, and corpulence, combined with diet
adapted to the various disorders mentioned.
In surgical practia.vihsa the solution of the proper strength is brought into
contact with diseased tissues, a brisk effervescence takes place and continues until lU
the pus -corpuscles present are destroyed. This solution may be used topically it
nearly all cases of catarrh of the upper air passages in the form of a .spray, and it m«j
be used as an antiseptic after the removal of pus in empyema. The substance
possesses the advantage over other antiseptics of being bannless, and can therefore be
used freely in diphtheria and croup. There are so many indications for its employment
that it would be diflicult to mention all the topical uses, although the following may he
referred to, viz., boils, carbuncles, indolent ulcers, carcinoma, and venereal diseam
as an injection.
The gynaecologist will find numerous applications for this agent. It may be used
in the form of a douche in leucorrhcea, elytiitis, and vaginismus, and a. cotlon-wool
tampon may be saturated with it and placed in a gelatine capsule (veterinary size) and
introduced into the vagina in the case of ulceration, vesico- vaginal fistala, and
endometritis. The ophthalmologist and aunsf will likewise find that it furnishes then
the most complete and safe antiseptic that can he had, and gradually its employment
will extend to every department of medicine and surgery.
The most flattering commendations of " March and's Peroxide of Hydri^en
(medicinal)" have been given voluntarily by numerous well-known anthors u>d
contributors to medical literature within the past few years, some of whom maybe
mentioned as additional evidence that the methods here recommended are woi thy of
further investigation : Dr. W. B, Clarke, of Indianapolis, Ind. ; Dr. Geoi^ B. Hofie.
Surgeon to the Metropolitan Throat Hospital, New York ; Dr. J. Mount Bleyer, of
New York ; Dr. Robert T. Morris, of New York ,; Dr. Paul Gibier, Director of lb*
New York Pasteur Institute; Dr. R. Chare;,!, of St. Cloud, Minn.; Dr, E. R.
Squibb, of Brooklyn, N. V.: and others whose names cannot now be recalled.
Dr. Morris refers to it as "the necessary peroxide of hydrogen," and I have fooRil
Marchand's product to possess in a remarkable degree the properties so essenlUl l»
-■- , unifonnily in strength, purity, and stability.
PEROXIDE OF HYDROGEN IN GYNECOLOGY
AND IN OBSTETRICS.
By EGBERT H. GRANDIN. M.D.,
(Pnbltshed by Tht Times and RrgisUr. of Philadelphia, Janu«ry jt, iftoi.J
VI131 proportion of caaos to pnve
il when iirosent, ut abort It whi
of peroxide of hydrogen (H, Oi) in genetnl surgienl practice have
lecently been heralded by Dr. Robert T. Morris, of this city, in the columni of 74/
Tintei and RegiiUr.* The object of the writer is to exemplify his personal experience
with this agent, through the brief record of a few cases in which he hu t«i[e<l tl.
Case I. Sui-mammary aiictss. — About one year ago I was consulted by a Mtii.
G. She was mining a two and a half months' puny infant, notwithstandini; the (act
that the right mamma was fairly riddled with sinuses, and the left preMiiteJ to iny
(ouch faint lluctnation. Her previous medical attendant had exhnuiitiid all routine
measures, and yet, as she expressed it, " she was going from bad to wurne." She had
hectic fever and other symptoms of sepsis ; her appearance sugi;ci<teil the abiolule
necessity of rapid action.
l.at once weaned the child, of course ; made a deep incision in the left mamma,
-exit to a mass of fetid pus, washed out (he cavity with bichloride (i-i,ooo), ami
with gauze. I Ihoroaghly wetted the sinDses in the right mamma, iirigaletl
ed them similarly. In a few days I had control of the lepiili. but (he
membrane and its product resisted all my efforts. In deH]ialt, and without
hope of success, I washed out the cavities with peroxide of hvdrojen (half
diluted with glycerine), and applied a compression gauze bandage. At the end 'if tan
days the abscesses were cured.
Case If. Suppurating felvit htmatociU. — This ca«e wa« wen in coniullation.
The patient was a young prostitute, and (he only etioloitical cause 1 could deiermln*
was copulation during menstruation. The tumor bnljcir in the rctto-utpflne pouoh,
and I treated it as rollows : Under antiseptic irrigation I atplratad along the fingar
as a gaide, and obtained a mixture of blood and pu>. Using the aaplrator mn^tli u
( director, I enlarged the opening transversely, Buflicicnlly lo admit a Palmer dilator
Inserting this I divuUed. curetted the cavity — which mcaiured fullv three inch«a
iqoare — and washed it out with equal parts compound tincture of iodine and watAr.
I next inserted a flange-rubber drain tube. The cavity was waahed out dailv ihroiu^
this tube with two and one-half per cent, carbolic, but c^titrary to my experience with
limilar cases, it had nut contracted much at the end of a week, and wu ililt wctellng
pus. I then inserted a small Chamberlain elasi uterine lobe, and dittcnded Iha
eavitj with undilnted peroxide of hydrogen. l'hi> checked nupputaliiin at once, and
trben the patient was teen three weeks tbereaflcr, an induraliun in the pontefUrt
taf^nad cul^de-sac was the only remnant of the hematocele.
Case III. Piutpnal uflie tndamettilit. — Seen in coobuliatioo. PUth day
post4)3niim. Patient had fcetid lochia, tefidemett over Dleni, Hie tA umirttttMu,
rapid pnlse. A nsmber of intra- uteri oe bicbloiide doachci had liera adniiaiUcmf
Iiefore I saw the caie. Havii^ differeolixed extra uterine toarce at ihc gratiai
a^>sis, I curetted the carity of the utenu, accordiog lo (he mclbod I have rep«ai«41y
described and advocated, removing a majM of d^encraled d*<'idii»i maltcf, «M thcs.
I««ury Punlrlf vf Hf 4r«f«,'
instead of applying pure pbenic acid 10 the cavitj', and irrigating it with iodine and
water, 1 washed it out through a Chamberlain glass tube with a pint of peroxide of
hydrogen (undiluled). The local sepsis was thus at once checked; the patient made
a rapid convalescence under the means which suggest themselves for meeting the
sepsis already in the system.
These cases typify instances in which the peroxide of hydrogen will be found
useful by the gynecologist and obstetrician. As opportunity offers I propose to resort
lo this agent in vaginitis, urethritis, and purulent cystitis. Furtlier, and in ihi^
direction I am as yet only experimenting, I am hopeful that in this ajjcm we will
find we possess a means which will enable os to avoid laparotomy in ceitain a
of pjoaalpinx. My conclusions on this point, however, it would he prema
My iJiperience thus far with the peroxide of hydrogen justifies the statement thftl
it is absolutely harmless, and that it is at the same time the most efficient of all the
agents at present at oar disposal for preventing the ravages which uncontrolled
suppuration is capable of causing.
SINUS TREATED WITH PEROXIDE OF HYDROGEN.
(Extract from /VofftVir, Richmond, Vn., February, 1891.)
Dr. William F. Waugh tells in the Times- Riiisitr of an old woman who stepped
on a nail, which penetiated the foot almost to the superior surface. A sinus formed,
and had been discharging for two months when the patient was first seen. Marchand's
peroxide of hydrogen was injected into the sinus by means of a hypodermic syringe.
The first effect was to destroy (he leather of the piston. The sinus was found to be
□f a horse-shoe shape, the probe passing almost through the foot, between (he mela-
larsal bones, and when the peroxide was injected a hard lump could he felt one inch
from the opening on the sole of the foot. This was laid open, and a stream of pero-
xide was sent through. Kesuli : Cured in a week.
DIPHTHERIA AND THE USE OF HYDROGEN DIOXIDE
IN ITS TREATMENT.
Rtad be/art the Ckemiial Society ef Maryland, February 6, iSgj.
By Dr. EDW, J. BERNSTEIN, of Baltimork.
{Extract from Maryland Medical Jaurnal, February 21, 1891.)
In this very elaborate paper. Dr. E. J, Bemalein says : (p. 361). , . In nqr
first case of diphtheria I began Ihe use of Sulphide of Calcium, but finding that not
only was it disagreeable 10 both taste and smell, and that it also soiled the bed lineii
and clothing of the patient, bn( that Ihe disease continaed to gel worse, that the
membmne which at first was limited to large necrotic patches on the tonsils, aov
covered the entire anterior pillars of the fauces and the uvula, which was no*
considerably swollen.
I discarded the nostrum and began the nse of Hydrogen Dioxide, wbi-h I directed
lo be sprayed into the throat every hour of the day and night, gradually relaxirg Ihe
number of night sprayings as the case went on to improvement. I also directed ihit
the nose should be sprayed at least twice a day with ihe same solution, Wllhin a few
hours the mother said she noticed a change for the belter in her child, and when I
made my evening call it was quite perceplibie. I also noticed, which fact I have since
seen corrohorited by others who had used (he drug, the better color of ihc ehiW-
The lips, which before its administration were quilc blue, were now of a healthy icd
The membrane in the throat had made no increase By Ihc following momiie
ts a decided decrease in the pseud o.membrane, and from now on began t
In conjunction with the above local treatment. I gave large doses ol line, (em
chlo. m combination with tonic dose of quinia every three hours.
Cream of tnrlitr lemonade was given ad libilum lo appease thirst aad to relisve
ccngeition. The air of the room was regularly charged with steam, generated on a
small alcohol stove, to which had been added an alcoholic solution of nienlhol.
eucalyptol and thymol. It is well to say that the strength of the hydrogen dioiide was
50 per cent. ofCh. Marchand's 15-volnme solution.
In three other cases which came under my observation, I followed out the ^anie
line of treatment, and each recovered without any untoward after elTects. In the hope
that some of you here this evening may be induced to try this plan of treatment, I
submit this paper.
HYDROGEN PEROXIDE IN DIPHTHERIA.
Bv U. V. ADAMS, M.D., of Pulaski, N. V.
(Published in the MaiUal Era of Chic^o. III., March. 1891.)
Thearliclein the December "Era "copied flora the "Medical Times," by Dr. Georee
W. Major, in regard to the ase of Peroxide of Hydrc^en in diphthetia, I can heartily
indorse. I have just discharged three cases of diphtheria that I treated with Ch.
Marchand's Peroxide of Hydrogen. I sprayed the throat with an atomizer filled with
full strength IS-volume sulutioo of peroxide in the early stages. The tnembratie was
removed almost at once, and after the first applicatioa and one complete ckaring of
the throat. I then reduced the is-volume solution by adding three parts water to one
of peroxide, and by spraying tbe throat ihorouglily as often as once an hour, all
membrane was destroyed, the breath was kept sweet, and the throat in a fairly
comfortable condition. When used at Hist in full strength the patient may complain
of a alight smarting, but no irritation results.
The atomizer should consist of nothing but glass and rubber, as the peroxide has
a. sEniDg affinity for all metals, except gold, silver, and the rare metals. -
I can assure all who fry Peroxide of Hydrogen as a local application in diphtheria
that they will be thoroughly well pleased with it.
SCARLATINAL DIPHTHERIA.
By WM. F, WAUGH, M.D.
(lixlracl from The Timn and Hegiitir, Philadelphia, March 7, i9yi.)
I desire to place upon record a case that is unique in my own experience ; though
roy readers may, perhaps, have had better results. The case was that of a child under
four years of age. He had been attended by a dispensary physician during the lirst
part of the illness : and this gentleman, when he gave up the case, had given a gloomy
proenosis. with which I heartily coincided. On my first visit I found the child's throat
covered with blackish sloughs, the lips and tongue covered with fissures and ulcers, the
BMC discharging freely the irritating and offensive secretion of nasal diphtheria, the
eyes showing spots of pus at the inner canthus. The child complained of earache and
M pain in the forehead, so that the disease had passed up the Eustachian tubes and
into (he frontal sinuses. Reddish spots and blotches appeared on the face aud body.
The stench was dreadful, the urine almost totally suppressed, but the few drops that
e passed could qui be saved for exaoiinarion. The child had been deli
very of msny such c:
e time, not being able to rect^ize h
slomach retained miUt fair!)' well.
It has not been my good fortune to v
fact, the more extended is my experience with diphtheria, the
especially when it has become firmly established in the Schneiderian mucous membrane,
and in the pnssages leading from the naso-pliarynn,
I felt It my duty to infonn the parents that death was the only result to be
cKpeelcd : and that they could be very tnankfal if their other children, siji in number,
should escape.
However, I gave them a bottle of Marchand's Peroxide of Hydit^en, and. directed
them to syringe the nostrils and wash the mouth out with the solution diluted to one-
fourth its strength. This was refeatid fVery hour, day and night. No other treatment
was employed, and whiskey was given with the milk, as the only food. The child
began at once to improve ; the right tympanic membrane gave way, and then Ihe
solution was thrown into the ear, and bubbled out at the nose. The urine began to
be secreted more freely , and the child was pronounced out of danger in one week from
One of the other children was seized with sore throat, enlarged tonsils and
torticollis ; another had a mild attack of scarlatina, but the others escaped without
-antracting the disease. This in itself is notable, as the children were all kept al
THE PEROXIDE OF HYDROGEN— ITS USES IN
ABDOMINAL SURGERY.
By CHARLE.S P. NOBLE, M.D.,
SuTgtan-in-Char^e of the Kensington Hospital for Womin, Philadelphia.
{VMhMsheAhy Philadelphia Midical Niws. April nth, 1891.)
I The importance of the Pero^ride of Hydrogen as a germicide, and more especially
I as a pus-destroying agent, is becoming firmly established by rapidly accuraulatiof
' clinical evidence. A very considerable experience with the drug has made me entf.u
siaslic concerning its remarkable qualities; and I find myself extending its applicftlioD
almost daily. In genera], in order that antiseptic or germicidal agents may be med
eSectively, it is absolutely essential that all foreign material, discharges, etc., be finl
removed, so that the agent may be brought in direct contact with the surface 01 tissne
to be acted upon. It is also true that the power of penetration of the antiseptics in
common use is slight, so that they are reliable only in combating strictly mperficili
I septic processes. This is particularly true of corrosive sublimate solution, which, by
its action on albuminous discharges, forms an impenetrable covering which prevents
the solution from coming in contact with the tissues to be acted upon. In this respMI
the action of the peroxide solution is essentially different. It attacks, disintegiatet
I and oxidizes all dischai^es and dead tissue with which it comes in contact, thusbviV'
ing its contact with and action upon underlying tissues. Moreover, ihe producB4)(
its activity escape as water and carbonic acid gas. At this lime I do not propose to
discuss the relative value of the peroxide of hydrogen as a germicide. I believe thrt
our knowledge upon that subject will be far more exact after a little time than it is ■!
present. The fact, however, that this agent has the power to oxidiie dead oi^tnie
matter suggests (o my mind a wide field of usefulness for it in preventing saprEetnw or
ptomaine poisoning, in the treatment of suppurating tracks and cavities in wMdl
dependent drainage cannot be had, and in which free irrigation with water is impr^
dcable.
depen<
dcablt
Hi
6?
In my work in abdominal sui^ery I have found Peronide of Hydrogen of positive
In cleaning Ihe hands preparalory to operation I have found it very useful,
especially when the skin about the finger-nails has become somewhat homy or rough-
ened from too much u^e. or from frequent washings, or from prolonged contact with
antiseptic solutions. Its power to loosen and to remove dead epithelial cells, and to
soften the skin about the nails, is quite remarkable. Moreover, all foreign material
about the nails is either ojiidiied and removed or is made more accessible to the
sublimate solution which is used later. In practice 1 have used the peroxide after
scrnbbing my hands through three waters with soap and ihe nail-brush, then soaking
them in turn in saturated solutions of permanganate of potassium and of oxalic acid,
and before soaking them in corrosive sublimate solution.
fiacteriolf^cal ejaminations have shown that even (his method (omitting the
peroxide solution) does not make asepsis certain, as genns have been removed fron
the subunguial spaces after it has been faithfully carrier" -■ ' " ■ ' " ■
test the vriue of the addition of the peroxide of hydroj
liy bacteriological eiperiments, bnt practically I feel c<
securing that end. The settlement of the questior -
interest to all those who believe in satisfying an anti:
In the management of the drainage-tube after abdominal section, under special
conditions, the peroxide solution has been of signal service. In typical cases, in which
the drainage tube is removed after from one to three days, there is no indication for its
use. But when from any cause the drainage-tube must remain in longer, it is useful
in keeping the tube and drainage track sweet and free from pus. On a number of
occasions after a tube had been in place from a week to ten days, and Ihe dischaige
had become slightly purulent, I have been able to combat successfuliy the tendency to
Gappnration, to shorten (he tube gradually, finally to substitute a gauze plug for the
glass tube, and to secure rapid healing of the drainage track; when otherwise a sinus
would have resulted. One such case was one of a ruptured laige ovarian tumor,
having contents of a jelly-like consistency, which had become distributed ihroughont
the peritoneal cavity. Jelly-like material was discharged through the tube for two
-weeks, and yet by the use of the peroxide solution rapid healing was obtained.
Another case was one of post-operative itttra-peritoneal hemorrhage. Tarry blood
was discharged through Ihe tube for ten days, yet the same care secured (he same
result. Another striking case wa.« one of fxcal fistula which formed after the removal
of a dermoid ovarian cyst — presumably caused by the growth of a small bunch of hair
from the cyst into the bowel. The track was kept clean and the peroxide was used
fieely. The faecal fistnla closed in three weeks, and (he remaining sinus closed within
two months from the date of operation, being kept open for a time by an infected
omental ligature, and closing promptly after its diachai^e.
The peroxide solution has been applied to the drainage track and to the inside of
the tube by saturating absorbent cotton, held in a slender long-handled forceps, and
passing this down the tube. The peroxide solution has been used pure or diluted (one
to two or three.)
I have not used the peroxide solution within the peritoneal cavity during opera-
tion, but believe it will prove useful in disinfecting infected pedicles. In removing
pus sacs rupture frequently occurs, deluging the broad ligaments with pus. Under
these circumstances the ligature applied to secure the pedicle necessarily becomes
infected. Heretofore 1 have washed away septic material with boiled water, and
iBter applied bichloride solution on a sponge to the region of (he ligature. In such
cues it seems probable that the peroxide solution will be of real value.
In cleaning Ihe abdominal wound preparatory to removing the sutures, the
peroxide solution has proven very efficient ; especially if a dry dressing — boric acid or
iodoform — has been used. Finally, if any pus has formed in the track of the drainage-
tube or of any of (he sutures, the peroxide solution will remove it laore efficiently than
«nf other agent.
I
A r#.sum£ of the history and practical appli-
cation OF HYDROGEN PEROXIDE IN SURGICAL
AFFECTIONS.
Bv S. I'OTTS EAGLETON. M.D.
KtiideHl PAyiieian in the Childna't H:ip:!al. Fh:
{Medical and Surgical Reporter of Philulelphia, May
delpkia
I.)
lljidrt^n peroxide wa^ discovered by M. Thenard, a French chemisi, in the jew
1818. since which time it has, like many other therapeutical lemedies, lain donnant,
occasionally being brought forward by some "enthusiast" and its virtues highlr
extolled for a time. Bui [he drug, unei^ual to the task of proving all that had been
said in its favor, was again and again returned to its stall of oblivion. Within the put
few years, it has been brought before the medical profession, on account of its
antiseptic properties, and apparently has awakened into active therapeutic life.
In looking over the literature on the subject, I find that Dr. B, W. Kicbardsoo,'
in iBJa, called attention to Che action of hydrogeti peroxide in an anicie upon the
subject, which eieited wide spread interest in the profession at that time and has led
In many experiments with the dnig, both in surgery and medicine.
It IS my purpose to contiDe myself in this study entirely to the trealmeni of
surreal affections. Before referring to the results of my own experience, during the
. . r_ .. ^^^^ J ^.j] iij^g^y allude to some of the most important mciogntphswhidi
C. T. Kingieti' beli
capable, even in very small
■ which is originated by
have appeared f i
that the substance exhibits striking antiseptic effects and
quantities, of arresting the so-ciiTled process of fermen ^
living organisms. He further calls attention to the fact that care should be
in making the solution neutral before usittg, and yet admits that neutral solutions ue
by no means as stable as are those of a slightly acid reaction. In closing fail
monc^raph he states that the eKpectations of several noted surgeons of France in the
treatment of wounds with this compound have been amply realized ; among thote
may be mentioned M. Baldy, M. Regnard and M. Beau. In summiDg up his kitide
he further says that, in his opinion, hydn^en peroxide is far superior to phenol, and
Chat it has been demonstrated beyond qoesdoa that all wounds treated with peioatdc
of hydn^n have progressed well, healing generally by first intention.
A. E. Prince' speaks most favorably of the results obtained with this remedy.
C. E. Shelley' considers it to possess aniesthelic properties, and at the saine time
claiming for the drug, not only a pas-destroyer, but that it is an actual stimuloal to the
surface of wounds. To the carefully conducted experimentsof Dt. P. Miquel, qootod
by W. D. Biiett,* we owe the establishment, on a firm basis, of hydrogen pennudn V-
a positive germicide. The line of experimentation pursued had the following tlim ; la
determine the quantity of various sabslancea, commoijy used as gemiicides, trtiich.
added to a quart of beef tea, would prevent decomposition. Miquel found amoi^ K.
n.Tr. -M. Loc. Umd.. ]
•C. K. Shell«y. Ptmetih,
X..AIhnla!>l andS.Ji^um.
%
. kilirw
The resalts thus obtained plnce hyilrogen peroxide ahead of bichloride mercuiy
as 8 germicide, with the advantage, also, of being absolutely void of any toxic action,
while Ihe corrosive sublimate is a most virulent poison. Bizett' claims that wben Che
jnire peroxide, which is syrupy in consistence, is brought into contact with living
tissues, it acts as a direct caustic. Various experiments were made by H. GiRord^
directly with ihe disease germs, thus testing the germicidal action of Ihe peroxide.
Two methods of determining its ability to destroy germs, were used, that of Koch, and
his own well-known method. The preparation of peroxide used, was tbat of Chas,
Marchand's {15 vol.). Gifford found that the white and yellow cocci, as well as the
bacilli anthrax, were killed in exposures of from | to li minutes. It required but | of a
tnioate lo desttoy fully developed anthrax spores. He further found that the solution
exposed for 40 days, to a temperature of 68-73° killed the yellow pus cocci in from
lo-ll minutes. The same solution of peroxide, when diluted with four times its bulk,
e of 30 minutes lo kill the pus cocci. If diluted with an equal
' "1 j minute. After an experience of six months. I. N. Love*
soma np the action of hydrogen peroxide as follows : It is a most efficient means of
cleansing purulent surfaces, deep cavities and sinuses, stimulating the healthy process
in utceiHling parts. As a destroyer of microbes, a cleanser and securer of comfort, it
is of great value as a local application.
My own experience with this drag in suigical affections, during the past ten
months, has been most satisfactory. During that time I have used the remedy in Ihe
following aJTections : Abscesses (acute and chronic, of various kinds), suppurating
gands, sloughing gangrenous wounds, empyema of the chest, necrosis (general and
calized), suppuranve otitis medih, and wounds of all descriptions. 'Hie ages of the
cases treated, varied from two to thirteen years. The mode of applying the peroxide
was as follows; All cavities, crevices, etc., were syringed with the bichloride of
mercury (1-2000, to 1-6000) and then carefully cleansed with the hydrogen peroxide
(Marchand's).
At Grst one volume of this solution was diluted with two to three times its bulk.
Later on, I used the full strength. The first effect noticed after applying the
peroxide, was the rapid oxidation of all purulent or bloody materia!, which woald
cause the distention of crevices, no matter how minute, with the oxygen, which was
eliminated as a frothy (often yellowish, depending upon the quantity of pus present)'
bubbling substance. After the oxidation was completed, Ihe wound was always left
in a clean, sweet condition, absolutely free from pus. The wounds were then gently
dusted over with iodoform and the Dsual antiseptic dressii^ of gauze, etc., were
applied. On removal of the dressings, a few days later, it was noticed that the
wounds were in almost every instance cleaner (especially marked in acute cases), more
healthy in appearance and with a decided diminnlion in the quantity of pus secreted.
The thought being suggested, that possibly the bichloride and not the peroxide was
instnunental in producing the favorable results noticed, I commenced a series of
oonlrol experiments. I would, at one dressing, use simply the bichloride of mercury.
following this, at the next dressing, with the peroxide. Thus making actual
ame cases. After several alternate dressings as above, I found
It the hydrogen penwide perceptibly diminishei! pus formation to
__ ^i iply the bichloride alone.
a much greater degree than simply tl
•H, Giffonl, Mtd. Rtc,
■a Af. aiJ S. JuMrHol, tS
N. S.
The belief that iodoforin should not be used in conjunction with the peroxide, for
tfear of liberating free iodine, which, as a direct irritant, would defeat the object in
-view, is, I helieve. erroneous. I found that when a quantity of iodoform was pUced
in a small receptacle covered with the peroxide solution and then set aside for periods
varying from three hoars to three days, on being treated chemically for free iodine,
-with the ordinary starch test, gave negative results. Although one drop of a solution
of iodine, on being added to the same solutions, g^ve a brilHant reaction on addition
■of the starch.
Id all cases in which the peroxide wc
healing effect upon the granulating tissue
oxidizing action on the pus and the din
"' ' either directly or indirectly, i
1 a fair trial, I have observed
is therefore evident that, owing to i
n of the purulent secretions after i
a destruction of the anthrax bacillus.
In concluding my article. I think, from the chemical as well as the experimental
evidence which has been deduced, we can safely sum up the action of peroxide of
hydrt^en in the treatment of snrgica! affections, as follows :
I. Hydrogen peroxide is a positive germicide and a possible stimulant to
-granulating tissues.
3. Owing toils especial property of eliminating oxygen, it is of unparalleled value
■n the distention of supparalioe sinuses and cavities, especially in the mastoid region,
-or where it is almost impossible to reach unhealthy surfaces by other means.
3. The diluted solution is perfectly harmless and can with safety be used in any
*juantity.
4. The strong concentrated solution, syrupy in consistence, is a direct irritant 10
all tissues and should never be used.
5. It possesses healing and cleansing qualities as well as those germicidal in
6. When exposed to light it loses strength ; care should therefore be exercised in
keeping the bottles well stoppered with rubber corks, and in a cool, dry place.
7. Fibrin, cellular tissue and some metals, instantly decompose it. In contact
with sugar and starch it eliminates carbon dioxide (COi).
8. In washing suppurating surfaces, it should be used until oxidation ceases,
4hus showing a complete destruction of all existSng pamlent material. '
EXTRACT FROM PAPER ON "ADJUVANTS OR AIDS TO
GVN.*:COLOOY— NEITHER MEDICAL NOR SURGICAL."
By C. a. PHILLIPS, M.D., op Boston, Mass.
Atlantic City,
. . Another local application of great service in the treatment of n^nonlueal
-«r syphilitic and all ulcerative conditions of the genital organs is Marchand s Peroxide
«f Hydr<^!en. While its power to destroy germs and septic matter with which il
comes in contact is unsurpassed by any other germicide or antiseptic, it is perfectly
barmlesE to living tissues. With a swab of cotton saturated with this solution the
parts can be more thoroughly cleansed than hy any other means with which I an
acquainted, — thus removing effete poisonous or septic matter, and I cannot undetstand
Miherein this is any more objectionable than cleansing the skin with soap and water,
or the teeth with a brush.
MEDICINAL PEROXIDE OF HYDROGEN AND GLYCOZONE_
By Dr. J. H, De wolf, of Ballimore, I
(Tkt Southtm Mtdkat and Swrgical World, of Baltimore, Md., August, 1891.)
The topical application of Oiygen is capable of immense benefit. In the pitting;
of Small-pox 1 most earneslly advocate atid urge its use, either in the form of
Glycoione or properly diluted Marchand's Peroxide of Hydrogen (Medicinal). I
believe much deformity can be obviated by its use, and the force of the disease-
lessened. Foul and indolent ulcers, when treated by iodoform, caibolic acid, etc..
are apt to poison the patients ; such cases have occurred. With oxygen that would
be impossible. In large suppurating sores, where the various gemiicides are
dangerous on account of tlie la^e breach of continuity and absorblion of the poison,
Ihe topical application of oxygen is perfectly safe, and to say the least, equally
efficacious.
Opthalmia is advantageously treated by the topical application of either the
Peroxide or Glycozone. Styes can be aborted if Glycoione be rubbed on the lids-
at the commencement ; and as slyes are painful, and swelling and pain last for a few-
days, the use of Glycozone is satisfactory to both patient and physician. In nasal
catarrh, when the mucous membrane is dry and crusts form, prompt aod more
satisfactory results can be obtained Jroin Glycoione than from any other means known.
In the various chronic inflammations of the throat which are ordinarily obstinate
to treatment, I have frequently satisfactorily treated by the Peroxide (diluted,)
especially when the orifice of the eustachian tube was closed by swelling, and the
patient rendered uncomfortable by temporary deafness and ringing in the ears,
PEROXIDE OF HYDROGEN, MATERIA MEDICA AND TflERAPEUTICS.
Vol. II., Page 681, iBgr. By JOHN V. SHOEMAKER, A.M., M.D.
Professor of Materia Medka, in the Medico Chirargical College, of Philadelphia, Pa.
PHARMACOLOCV. — The usual strength of peroxide of hydrogen is called the fifteen-
volume solution, ijecause each portion of Ihe solution yields fifteen volumes of the
oxygen. It is prepared by Charles Marchand, New Voik, for medical use. and is an
active oxidizing and antiseptic £«ent. Glycozone is the trade name of a similar
preparation in which glycerine is the vehicle.
THEkAl'Y. — Though less powerful than many other antiseptics, the solution of
hydrogen peroxide has a special place in sutgeiy, gynecology, and obstetrics, on
account of its power of decomposing pus and destroying the microbes of suppuration.
Being free from all irritating qualities, it can be poured overwounds, injected into
sinuses, or into the ear, or used as a spray in ulcerations of the pharynx and of the larynx.
It produces a frothing up when it encoanlers pus, owing to the liberation of
oxygen, and the cessation of this commotion indicates (he removal of all pus. The
surface of the wound or ulcer becomes blanched, but it is not injured by Ihe application.
Tubercular and mammary abscesses especially are well treated in this way. In
ulcerative tonsilitis, fetid breath, and in some bronchi^ affections, a spray of dilute
hydrogen peroxide is productive of benefit. A spray of this agent is likewise of utility
in chronic na.^al catarrh, ozcena, and scarlatinal angina. It has been administered,
well diluted, in gastric affections, and is said (0 be very useful in flatulent dyspepsia,
heartburD, catarrh of the stomach and bowels, etc.
In diphtheria and croup its value has been established ; a two volume solution is
Ipecially recommended in young children as a local application, and particularly after
separation of the membranes, in order to remove the odor and disinfect the surface.
Internally it is loo quickly decomposed in the stomach to render much service as a
:e of oxygen to the blood. It might prove of value in gastric ulcer,
rEROXIDE 0¥ HYDROGEN IN niSKASES
MUCOUS AND SEROUS MEMBRANES.
Bv W. S. MULLTNS, M. D., HEBDHBaoK. Kv.
if A paper md before Ihe Tnternatioofll H«ms*>piilh!c Clingrea, Atlantic Cif
Puhtithfd f*y ihe^' Mediiiti Ert^' of Chicago^ t^rpembet
Since the discovery of PcroKide of Hydrogen in rSiS by the 1
chemist, Thenard, and its introduction to the medical profession by Richardson, in
1858, ic has, like most remedial agenries brought forth by the empirical school of
medicine, enjoyed great favor for a few years, only to fall into disuse, not becaUM
it did not possess virtues peculiar to itself, but from tiie fact that it was an im ■
chemical substance, producing esehaTotic effects when applied locally,
poisonous effects upon the system when diluted.
What it may do outside of its remedial effects upon niueiius and se
membranes, I know not. But the results obtained in diseases of the nose, throat,
ear, skin and womb, I have had an extended clinical experience of ten years.
Marchand's I'croxide of Hydrogen, Hj Oj, that I speak.
I know of no chemico-therapeutical substance of modern use, that brings the
physician a more decided and powerful curative action, in its range of indications.
Before entering into its clinical adaptation, permit me 10 say, by way of caogon,
that in no instance, and under no circumstanc«s, should the commercial and
poisonous peroxide tff hydrogen be used. Neither should it be applied or inhSled
except by means of glass, rubber, porcelain or gold instruments, as its effects are
certainly contaminated, if not entirely deslrnyed, by any other applianct^s than the
-ones named.
In acute, subacute or chronic cases of catarrh of the head, when accompanied
by an acrid, excoriating discharge, and much sneering, it will almost cert^nly
control the sneeiing and change the nature of the discharge from acrid to bland.
In chronic nasal discharge, either from the anterior or posterior nates, eH
yellowish greenish fetid character, with an accumulation of^ hardened pus at
scabs in the nose, it will soften them and cleanse the nose effectually.
Tn both conditions of nasal catarrh as enumerated 10 be followed by 1
applicatlnn of glycozoue On a cotton swab; or, belter still, to saturate a ami
cotton tampon of borated cbtton with the glycowme and place it well up each ■
nostril; allow it to remain from one to two hours, cautioning your patient .lo
— - '\ gently and to desist from any forcible blowing of the " ' "~
In granular pharyngits, prodnced tn- .smoking, .ipply by means of n spray 11
follows:
reroxide of hydrogen, 15 volumes, z «»■
Aqu? distillata. J ijss.
To bo followed by inhalations of ozonized vapor. It is a ratlical cure. Tbn
sprayings and three inhalations in bad ca.ses, and once a d
be used, cautioning your patient to hawk as little as possible. ,-^
In diphtheria, an early application of copious and freiiuent spraying of the HOpfT
mouth, throat, pharynx, and larj'nx, Hdminisi-""' ■"■''• « ",;»>..-" r.i- — '—'.
Peroxide of hydrogen, 15 volumes, J. ssi.
Aqua distillata, | iij.
When diphtheria is well developed,
niislrtls, pharynx: mouth and Urynx, with a 9
Peroxide of hydrogen, 15 volumes, 5 jss
Aqua distillata, f ss.
The above is the best local applicati
lie used of course with the indicatcil internal 1
iple OLses, alxMH 1
(■ing of the' HoBSJ
::9
nade as follov
PeroKide of hydrogen, 15 volumea, 3 jss.
Glycerine. % j.
Koch'a lymph or Shucley-Gibbea indine, chloride
lowhere in benefiting your consumptive patients,
oUowing:
Peroxide of hydrogen, 15 volumes, = ij
Pure glycerine, ; j.
M. Sig. Shaite well, inhale for len minutes, three
ritfa the folio wiag:
FL ext. Hydrastis, 1 s'i.
Glycerine, % j.
Kreasotum, M. vj.
Aqua distitlata, J jiis.
M. Sig,; As directed. _
In cases of the many different varieties of eruption seen so often upon the face^
if yojng girls from 15 to 23 years ofage, including blackheads, by applying first
or about three minutes, to the face a flannel cloth as hot as can be, wrung out of
lot water, then apply by means of a sponge, Marchand's full strength I'erojdde of
Sydrogen, followed by mbbing well into the skin, boracic acid; one to three
pplications per day, according to the severity of the case, will give you all thJ '
epiltation you desire as a dermatologist.
CONJUNCTIVITIS^-The following makes a ..plendi.l applicati.
atarrhal or granulated conjunctivitis:
Glycerine. J j.
Boracic acid, 3 j-
Mixwell in a mortar and add Teroxide dI Ilydrogrn, ; J. -M'P'j' '') '
I camel's hair brush. Keep well corked.
CHRONIC ULCER.— 1 have just dismissed, from mv office, cured,
iirontc . ulcer of the 1^ of fifteen years' duration. It was one im'h dee;
ncfaes long and two inches wide.
The only treatment the patient received was the application of peroxide (
dropped on carefully night and morning by an ordliuuy' ]
s dropper, being careful not to disturb the white foam thereon. The whole
ras then covered by borated cotton, saturated with glyciuone, oil silk over this,
fae leg kept bandaged from the foot to the knee by an Empire elastic liandagc — by
he way, far superior Eo Martin's.
During the three months he was under my treatment, he receiv
tilphur, 47m, ten doses of Arsenicum 3^, ten dos>^ of Argentum
ifLachesis 61, ten doses Calcarea sulph. 6,, which, in my mind, contributed n
B curing the case.
GYNECOLOGY.— In the field of gynecological work, nothing serves me
rell and often, nor is there anything, in my opinion, to take its place.
ABSCESS Ot" THE LABIA.— Puncture with bistoury, cleanse with [,
>eroxide of Hydrogen, 15 volumes, then by hypodermic syringe inject slowly i«
fie sac, 10 or 15 drops of Glycozone; very little reaction follows, and t[)|i
tsults are perfect.
VAGINITIS.— As a vaginal douche, use hot buttermilk; then by aid of t
peculum and a small cotton swab, on an applicator, applying the pure Peroxide
ajdrogen, i; volumes, to the entire mucous membrane, including the cervioiitB
•■■'■'■ '■ ■ wrt into thil
peina «
ulUmed
. be followed i
i_ applic:
IKc the SI
1 of Glycc
for vulvitis.
e discharge is white and acrid, or
15 Tolumes, being careful not 10
n of a tampon, or tampons, satu-
ENDOMETRITIS.— In endome
yellowish, greenish and fetid, apply 1
wipe off the foam generated; follow by
rated with Glycozone.
CHRONIC METRITIS.— Copious hot water vaginal douches; then apply
full strength, Peroxide of Hydrogen, 15 volumes, followed by tampons of Glycoione,
applied every other day. This trealraenC is worth the consideration of any member of
this institute. It is, of course, understood that in all cases the indicated remedy must
be used, combined, in the judgment of the physician.
In almost all cases where the Peroxide of Hydrogen is used in the nose or thitwt. it
should be diluted one-third, one-fourth, one-half, three-fourths, and sometimes four-
Bfths. with pure distilled water.
My rule has been, except in cases of nasal catarrh, accompanied with much
sneeiing and very acrid excoriating dischar^. to use it just strong enough to produce
a very slight, tinkling sensation.
It should be home in mind that, when used in the nasal cavities, it produces fre-
quent sneezing, and if too excessive should be diluted still mote. If its use on irritaled,
inflamed or idceraled surfaces should produce a loo free discharge of blood, you may
conclude that it needs further weakening.
If you de»re a better, quicker and more effective local treatment for carbuncles than
carbolic acid, in conjunction with your constitutional remedies; inject pure medicinal
Peroxide of Hydrogen by use of hypodermic syringe; a keen, cutting, stinging pain
follows. When the pain has subsided, inject by same means, a few drops of Glycosont.
I am only sorry my time will not permit me to enter as fully as I would like in explana-
tion of its beneficial use, and speak of its great curative powers in eczemalous vesicular
eruption, in vesicular erysipelas, in aphthous and cancerous conditions of the month and
of its value as an internal remedy in gaseous dyspepsia that will not respond to Lycopo-
diom, China. Argentum, Mi^e^uin, Phosphorus or Carbo v^.
As I have already indicated, I have great faith in the Peroxide of Hydrogen. In the
treatment of consumption. Give inhalations on alternate days, of the Peroxide, and
Hydrastis, at the same time giving nourishing food, and attending to other conditions.
It has helped me to core several well-developed cases of consumption. The use of the
Hydrastis is not original with me, bat the plan of alternating the two I have never
known 10 be used by others.
I am loth to leave this, to me, interesting subjecl. I trust that il may be of benefit
WAX IN THE EARS.
Bv A. S. TUCKLER, '93. C. M. C., S. F.
(Published b)' the Cali/ernia Mfdical Journal, San Francisco, CaL. June. iSga,)
.\ simple method of removing "wax In the eais," is
(Marchand s) warm it in a water bath, then with an slomi
five minutes. This will soften and partially dissolve the
now remove the mass and to the surprise of the patient, the
mediately restored. A little more of the spray to cleanse
necessary. This is a far sa[<
perforate tympanum, an expei
lake peroxide of hydtngeo,
spray the meatus for about
m. \a ear spoon will
£ of hearing will be bn-
pans will be all that it
[fer method than the digging out proeefs and not liable U
hich the writer has been subjected 10.
SOME PRACTICAL POINTS IN THERAPEUTICS.
By JOHN A. LARRABEE, M. D.
Profwr of lie Prindplls and Practiei of Midiciiu, Nos^il.U College of Medicine,
Louisville, JCenlucty.
(Abstract uf paper read before the Louisville Medido-Chirui^cal Society, Oct. 2, l8gi).
Permit me, in conclusion, to make mention of those therapeatics agents which, dur-
ing the summer months, have been weighed in my practice and have not been found
wanting. In enlero-colitic diarrh<ea, the so-called "summer complaint" of cities, de-
pendent upou the various micro-organisms, vitiated air, and bad food, salol, napthaline,
carbolic acid, (nascent), calomel in minute doses and nitrate of silver, have stood the
lest. In gastro-enteritis, I have found salicylate of bismuth useful, and in inflammatory
diarrhieas (the dysentery of some aulhors)of infants and older children, Rochelle or Epsom
salts in acid infusion of roses wilh small doses of laudanum. In chronic eases the nitrous
add camphor mixture of Dr. Hope has not failed. For the gastric fevers so common in
children, the preparations ammonia-phenique and sulpho-phenique o( M. Declat have
been used exclusively in a large number of cases with much better results than any former
treatment; also the same for the exanthematic. For "whooping cough," Declat's syrup
coqueluche is nearly a specific. In diphtheria, locally, Marchand's peroxide of hydrogen
and whiskey internally have established their value. A word in regard lo the use of the
Sroxide. It should always be purchased in the smaller tour ounce bottles, protected
im the light by blue glass bottles and corked with rubber. That sold by ;he druggists
from large bottles is, in the majority of cases worthless. It is a Very unstable article, and
unless it causes immediately a white, foamy reaction when brought into contact with the
false membrane, it should be discarded and another lot obtained. 1 am satislicd that
I use it more freely and more persistently than most practitioners. I use mops made
by twisting a sort of absorbent cotton upon sticks, usit^ as many as thirty or forty in
the twenw-fuur hours. Such mops will take up nearly a hnlf ounce apiece, and when
farced well hack into the pharynx, reach all parts. The gagging and resistance of the
child assists in the distribuciou of the fluid. As soon as a mop has been used it is com-
mitted to the fire. In this way I have treated the worst as well as the milder forms of
diphtheria with complete success. I believe that the systeniatic use of definite, although
often toxical doses of whiskey, even in children of tender age, to be the surest safeguard
against heart failure. _^ _^__
PEROXIDE OF HYDROGEN IN TYPHOID FEVER.
By H. F. WIGGIN, M. D., 55 w. 36TK st., new vork.
(Published by the .Vcw York Medical Recor,!, November iSth, iSgt.)
Having had good results in using Peroxide of Hydrogen locally in diphtheria
and tonHUitis, and in infected wounds, it occurred to me, when a case of typhoid fever
came under my care, during my summer practice, that this remedy might be Iwneficial, it
htiag the most powerful non-poisonous germicide we possess.
On August 34th I was called to see Abby M. , who gave a history of having been
in for a week with fever and diarrhcea. On examination 1 found a characteristic case of
typhoid fever with temperature 1044" F. ; pulse, 130; sore spots, abdominal pain, tym-
panites, diarrhcea, and mild delirium. I prescribed one ounce of fifteen volume peroiide
of hydrogen* to eight ounces of water, lo be taken every three hours, by the mouth.
On tne following Jay I found the patient more comfortable; teraperatore, lOS^F. ; pulse
112; had had only two movements during the twoiuy-four hours; less delirium and Uss
pain in head. On the 26th had had one movement; temperature loa^F, ; pulse, 104;
less tenderness in abdomen, and pain in the head diminishing. On the a7th, tempera-
ture, looi" F. ; pulse, gB; no movement; tympanites disappeared, and head, ihongji still
weak, clearer. On the agth, temperature, 99^° F. ; no movement. On the 30th, tem-
perature normal: pulse 84; formed movement. The case now went on uninterruptedly
to recovery, with nothing farther of interest to report On the gth of September I dis-
continued my visits, the patient being dischai^ed, cured, though weak.
One swallow dots not make a summer, but I report this case hoping that some one
who has larger opportunities for treating typhoid fever may take up the suggestion and
let the result be known. The remedy is perfectly harmless, easy to take, and apparently
was of very great value in this case.
1 . '"
serious
SUBSTITUTION AND ITS ATTENDANT EVILS.
By JOHN AULDE, M. D., OF Philadelphia, Pa.
(Published by T/uJeumal 0/ the AmericaH Medical AssociaJion.C'aii:iiS,o. III., Decem-
ber 5th, rSgi.)
The evils attendant upon substitution and sophistication of remedial agents havehHIE
been surmised; they have not, however, until recently, received attention at the handsol
the medical profession. Increased diagnostic skill, along with greatly impraved
facilities for the manufacture of medicaments, favor an approach toward mathematical
exactness in computing therapeutics results. When these are wanting we challangc the
character of the remedy. The question which presents itself ia: Has our patient re-
ceived the true medicament or a base counterfeit? However attractive in theory, it will be
found impractical for the medical profession to drift away from the pharmacists and it
should be our aim to reward the faithful and bring the guilty to punishment. The
friendly bond between the two professions should be honesty, as neither can afford to
work independently: there is an interdependence which makes them mutually helpful.
It is said of Liawson Tait, that he has returned to first principles and carries a nill
with him, so that when ergot is needed, he prepares it fresh with his own hand. Tta
reliable character of Squibb's ether has been maintained through his business sagaoty in
having it prepared chemically pure and distributed all over the world in sealed cans, thm
precluding the possibility of sophistication or substitution.
The life of a patient sulTenng from rheumatism may depend upon his being supplied
with sodium salicylate prepared by a combination of Merck's chemically pure bicaiboaate
of soda and true salicylic acid obtained from oil of wintcrgrcen. and yet lew phamudMs.
even in large cities, pretend to keep either in stock. They are the exceptioa in Phil*-
delphia. and doubtless the same is tme of other cities.
Some years ago Dr. Squibb, of Brooklyn, set his seal on Marchand'a peroxide of
hydrogen, by endorsing its character and defending its merits as the most poweriol and
yet harmless bactericide which could be employed in the treatment of various formidlble
and fatal diseases. Dr. Robert 1'. Morris, Dr. Paul Gibier, and other welL^mitn
authorities have corroborated his statements from clinical observation, and as«cOD*e-
quence, a revolution has taken place in our methods of treatment in both mcdicftl aad
surgical practice. The efficacy of this simple remedy, its inaocuousness and CKteodeit
field of application, have shed a flood of light npon modern therapeutics, but at the nme
time there has followed in its train a host of worthless imitations.
le substitution of the commercial forthe medicinal peroside is calculated to inirt
injury and destroy our conlidencc in a most potent remetiy. In the treatment ol
diphtheria, for instance, the commercial product is positivelj- harmful. When deaths re-
sults, shall we blame the attending ph)-*ician or the unscrupulous druggist who substi-
tutes a base imitation for the genuine product? And still, pharmacists who claim to be
respectable, do not hesitate to trifle thus with human life. Is it any wonder then, that
our mortality percentages are on the wrong side?
Cascara sagrada has been counterfeited and sophisticated Until it is almost impossi-
ble to secure a reliable preparation of this most useful medicament, although Parke,
Davis &Co. , the pioneers in its introduction, have adopted every means in their power for
the protection of the medical profession. Antipyrin, a patented preparation, has met
with phenomenal sales, and possesses distinct therapeutic properties, and as a result,
imitations and substitutes are ofl'ered to take its place in medical practice. Whether these
imitations are better or worse than the original product, I do not care to discuss; neither
is it for the druggist to decide. The decision here, as to any special remedy or prepara-
tion, rests entirely with the physician, as he alone is responsible for the condition of his
patient; no one else, not even the dru^^st, should be permitted to interfere with his
directions. Substitution is an evil which should be guarded against; it is an evil which
tnust be eradicated, orthe entiremedical structure will collapse. It is a duty weoweto
ourselves and to our patients to look after this unnatural condition oE affairs in which we
are so vitally interested, and the time is near at hand when a systematic effort must be
made with a view to accomplish the desired end.
This subject is commended to the attention of the American Medical Association,
with the suggestion that a committee be appointed who shall recommend suitable meas-
ures for the protection of the medical profession from the evils of substitution and so-
phistication on the part of unscrupulous pharmacists. Shall we have a list?
47 ig Frankford Avenut.
HYDROGEN PEROXIDE IN PELVIC -\BSCESS.
(Pablished by the Bac/crioi>gicai World rA Battle Creek, Mich., December, i8^i.)
We have for a number of years made the use of peroilde of hydrogen (Marchand's)
ID the treatment of suppurating surfaces, abscesses, etc., with excellent results, but have
never observed a more gratifying result than that recently obtained in a case of pelvic
abscess of long standing. The abscess discharged by a small opening just behind the
cervix uteri, and was very profuse, and extraordinarily fostid. Our stock of peroxide of
hydrogen happened to be enhausted at the time, the new supply ordered being somewhat
ddayed In reaching us, and we at first employed listerine, using it in the proportion of
onepart to three of distilled water. There was noapparent effect upon the discharge, as
re^iarils cither quantity or character. The odor continued as bad as ever. When thenew
•apply of peroxide of hydrogen arrived, we immediately began usinff it in the proportion
of one part to ten of distilled water, with the result that after the hrst washing the in-
tensely [uetid odor disappeared entirely, the dischai^ became healthy in appearance, and
dtmiiJshcd in quantity so rapidly that within ten £ys there was no discharge whate\-er,
except at the washing, and then the quantity evacuated was not more than a dram, when
it had previously been several ounces, besides continuous discharge in the intervals be-
tween the washings.
After the first washing with peroxide of hydrc^n, the patient's temperature, which
had for several months previously been above normal, fell to normal and has remained at
that point since. There is certainly at present no agent known which could properly re-
place hydrogen peroxide as a disinfectant of unhealthy surfaces.
It would seem to be especially valuable in the treatment of abscesses, the di
of which, through the relation of the cavity and the lower part of the alimentary ci
ustuilly possess so repulsive an odor as to render the existence of the patient almost un-
endurable. J. H, t.
DENTAL MEDICINE.
ByR. M. chase, D. U. S., M. D., Bethel, Vt.
Abstract of paper read before the New England Dental Society, October Sgth, i8gi,
(I^blished by the Jntemalianat Dental Journal. Philadelphia, January, 1892.)
Peroxide of hydrogen still stands at the head as a germicide, and undoubtedly is one
of the best antiseptics yet discovered to annihilate germs, bacteria, or microbes. Charks
Marchanid preparation, Hs Oi, is, I believe, the best article in the market, as peroxide
of hydrogen is very susceptible to certain conditions. To g:et the best results it should be
kept in a cool place, well stoppered and when required for use as much as desired should
t>e poured from a large bottle into a small receptable, and only what is to be used sbotlld
be exposed lo the light. When sinall cavities are to be cleansed it should be injected with
a small gloss or rubber syringe, as metal should not be brought into contact with it as it
quickly destroys its utility. For reaching pulp canals I find a. small glass medicine drop-
per very convenient as by pressing upon the rubber bulb quickly it is forcibly ejecto]
and is thus forced into the pulp canal without much trouble. I use a wooden tooth pick
reduced in size to still further push it into the root. In treating all ill'.conditions of tht
oral cavity I make it a rule to first rinse thoroughly the mouth with peroxide diluted, and
then apply remedies suitable for the same. Much more could be said and undoubtedly
will be brought out in this discussion upon this and other valuable antiseptics.
PEROXIDE OF HYDROGEN IN THE TREATMENT OF
DIPHTHERIA.
(Published bytheA^urM Western MidicnlJoumal,Wiavxx^\-a\ Minn., February, 189s.)
In the next chapter, we shall give further details with regard to the treatment of
diphtheria, but at this point we feel that we should not close without announcing in the
most emphatic terms, that one of the most available agents that we have for the fighting
of diphtheria locally, and preventing constitutionalinvolvement, is the "Necessary Peroxide
of Hydrogen" made by Chas. Marchand, of New York. We would take no chances by
using any other manufacture. Charles Marchand was the pioneer in the development of
this particular agent, for medical use. It is the "Medicinal Peroxide of Hydrogen wUth
can be depended upon to render diphtheria germs inert as thoroughly as water can bede-
pended upon to put out a fire, or as heat can be relied upon to annihilate the icicle. We
believe that every case of sore throat, whether pronounced diphtheria or not, as well M
every case of scarlet fever, should have applied to the throat at intervals varying acoard-
ing to the necessities of the situation, the full strength of the Marchand's Peioxideol
Hydrogen. It may be used as a gargle, though I am somewhat in favor of flushii^ the
parts with a good syringe, or if this is not available, owing to the objection of the patient,
particularly if it be a little one, atomizera are now furnished whidi act very efficieotly,
and by tising them frequently, the full effects can be secured. It is well to give intemoUy
occasionally, teaspoonful doses of theperoxide. It may be diluted or not, as one pleases.
All the secretion which has been swallowed will thus be acted upon in the stomach. In ad-
dition, there is a general accumulation of fermentative products in the stomach, undi-
gested food, etc. The oxidation of these irritants is desirable. If the patient complains
that the application is irritating, it may be diluted with one, two or three parts of water
The position which we took nearly four years ago with reference to the use of Perox-
ide of Hydrogen in the treatment of diphtheria in a paper read before the St. Louis Malt-
cal Society, has been strengthened with the experience which has followed. We would
emphasize every material point then made in that paper. If asked "if we were to depend
upon only one agent in the local treatment of diphtheria, what would we call for," llw re-
sponse would be emphatic, in thundering tones, "Marchand's Peroxide of Hydrogen," and
RECENT INVESTIGATIONS RELATING TO THE PRE-
VENTION OF DIPHTHERIA AND SCARLET FEVER.
By dr. J. LEWIS SMITH,
Professor Diseases of Children, Billrmu Medical College, New York.
Abstract of paper read before the New Vork County Medical Association, March aist, 1B92,
(Published by the Doctor's Weekly, March s6th, iSga,)
In his report the author entered fully into the patboli^^ and etiology of the two
diseases, aod dwelt at some length on their differential diaffnos'S. He related many
interesting facts in connection with the contagiousness of diphtheria, spoke of a case of
the disease resulting from the employment of a brush that had been used for swabbing
the throat four years before in a similar trouble. Does not believe diphtheria ever Orig.
inates Je novo, that it is dependent at all times on "he presence o£ e. specific microtHC.
Damp cellars, the presence of sewer gas and other unsanitary conditions contribute
largely to lis development. Many mild attacks of the disease are overlooked by the
attending physician, and as a consequence it is communicated to others, notably in the
school room. He believes in thorough disinfection as a means of preventing a spread of
the disease. Does not have much faith in sulphur for this purpose; pretem a strong
solution of corrosive sublimate or five per cent, solution of carbolic acid. This should
be used freely on walls and floors of rooms where the disease prevails. With the same
solution the bedstead and other articles of furniture should be thoroughly washed.
In ccamining patients suspected of having diphtheria or scarlet fever, the phy.
sictan should place himself on one side or in rear and not in front, as is usually the prac-
tice. In this manner he avoids thedangcrs ofany diseased matter that might be coughed
Up by the patient. After such examinations the physician should thoroughly bathe his
hands and face in a solution of corrosive sublimate. Exclude everybody but the physician
and nm-se from the room where a case of either disease exists. While small-pon is thor.
oughly under control in this city, he doesn't think it possible to gain such control over
the two diseases under discussion. The crowded condition of our large tenement houses
supplies so much material for their ravages that it is impossible to stomp them ouL For
the purpose of illustration, the reader related the following experience;
He was called to see the child of a poor woman, living in a tenement house in which
■here were twenty-seven families. He found a child two years old very sick with diph-
theria. Five other children lived in the same rooms; of these, two were away at the
time of his visit, at school. Just think of the hundreds of children thus exposed! The sick
child died two days later.
For purposes of fumigation the author recommended the followir.g;
If 01. Eucalyptus,
Acid carbolic, aa J j.
Spts. Turpentine. Jviij.
M. Add two tablcspoonfulsofthismixturetoapint of water and evaporate by aid of a
lamp; or cloths saturated with the mixture may be hung around the room.
Does not believe intheefhcacyof sulphur fumigation. Microbes in a state of activity
nay be found in the sweepings obtained from a room that has been fumigated with sulphur.
For the local treatment of diphtheria and scarlet fever, he recommends the following
B 01. Eucalyptus,
Acid Carbolic, aa 3 j.
01. Olive, I vij.
M. Sig. Apply every three hours.
Healso uses Marchand's medicinal Peroxide of Hydrogen one part, tn Ihree pans of
Jiicussed by lirs. 1.
:tion and quickly destroys the dipt-
', Tyndalcand KopUk.
1
SOME NOTES ON THE VALUE OF PEROXIDE OF
HYDROGEN
Editor of PractUf, Richmdnd, Va.;
Having read in the January number of your excellent journal, the experience o( Dt.
S. Potts Eagleton in the use of "Hydrogen I'eroxide in Surgical Affections," 1 am
prompted to send you for publication the kiUowing:
In January I was called to see a lady in her seventy-sixth year of age, suftei-inff, as her
husband supposed, from an inguinal hernia, but upon careful examination, I diagnosed
a dcep-Eiealed abscess, and at once ordered hot poultices, to be madeoE equal pans of
flax-seed and com meal, and applied in the following manner over (he skin: White ganie,
hot poultice, muslin, oil silk, After a few poultices had been used it was in a condition
to be opened. A good incision, giving free drainage was made. The cavity was tight
inches in depth. Every day the cavity is syringed with "Peroxide of Hydrogen" (Mar-
chand's,) full strength.
The lirsteffect noticed was the rapid oxidation of all purulent matter, which caused
the distention of (he cavity with the gas eliminated as a frothy yellowish (or yellowisb-
green) bubbling substance. After the oxidation is completed the wound is always in a
clean, sweet condition, absolutely free from pus. The cavity is dusted with iodoform.
and antiseptic dressings applied. The cavity is gradually healing up from the bottom.
In my experience "Peroxide of Hydrogen" (Marchand's) perceptibly diminishes the pui
formation. In this connection, 1 will alsostate that I am using 'Teroxide of HydtD-
gen" in a case upon which I operated February i6th, and from which was removed
a large multilocular ovarian tumor and also an enlarged uterus with many fibroids
(hysterectomy). The wound (stump) is in a healthy condition; her general cDndithnl
is good. Indeed, she is getting along finely. The clamp came away yesterday. The
sixteenth da^ was up yesterday, counting by hours, from the time of the operation,
'I'he wound is in a h^lthy state, and perfectly healed. Hardly aday passes that t amnot
using the "Peroxide of Hydrog™" in my practice, I send you these notes, hoping ther
will assist some brother practitioner who may be a reader of your practical joumiL
Doctors talk with each other about their cases, and I believe they are as much interested
in exchanging their experiences by correspondence. We are all mutually concerned.
Very truly yours, Robert T. Wilson, M. D.,
DIPHTHERIA, LOCAL TREATMENT.
Itv I. N. LOVE, M. D., St. Louis, Mo.
(I'ublished by the Medical Mirrer, of Si. Louis, March, 1892.)
Judgment should be exercised in this as in everything else. If we select the applkii-
tions properly they will be sufficiently agreeable as not to annoy or irritate more tlM
they benefit. It may be necessary to avail an opportunity for the application; for tbe
patient may be fretful, easily demoralited by being disturbed; we should wait untU rea
has been secured, until the sensibilities have been obtunded by proper internal mediolion.
We should bring to bear our ingenuity lo the fullest and diplomacy also; if possible ascB-
tain if the child has a fondness for any particular thing. We should arrange a plan by
n prospect may assist m accomplishing our desires.
For its germiciJal effect, and also for the removal of the mechanical obstruction
produced by the diphtheritic membrane, Matchand's Peroxide of Hydrogen, (medicinal)
should be used promptly, in its full strength, but later it may be diluted lo one-haif
strength. As Ihe mucoos membrane becomes exposed after the removal of the deposit,
by the means just mentioned, it is important to have on hand an application which Is
soothing', astringent and at the same time as much antiseptic as it can be made.
I We found the following valuable for this purpose:
^ Katharmon., I ij.
Glycerine, 5 j,
Aqu^e Cinnamonis, 3 iij. Sig,
The Peroxide of Hydrogen may be labeled No, i, the formula just written No.
3. The best means of applying both applications is ei^er by a glass syringe, or an
atomizer made of hard rubber; but incase neither of these appliances are at hand or
available, a piece of wire (silver or platinum) of good strength, may be bent, with a hook
at the end. in such a manner, as to serve as a probang by wrapping a pledget of absorbent
cotton at the point; the application may be made after thoroughly wetting the same
with the solution. No. 3 application should follow No. I, and will be gratefully received
by the little patient,
WOUND CLOSURE AFTER THE EMPYEMA OPERA'i'lON
By CHARLES W. AITKIN, M. D., Flemingsburu, Kv.
(Published by the OAU Medical Journal, of Cincinnati, April, iSga.,
Several times the writer has found it difficult to close the wound made in an operalion
for empyema, especially if the empyema was of any magnitude or of long standing, so
that the Iting's function was destroyed by compression, and bound down by adhesions.
Mrs, v., let. 3a, of Bath County, Ky., was confined April 20, iSgi. The physician in
attendance, Dr. Judy, informs me that there was nothing abnormal in the labor. On
April 30th the patient had a chill, and for several days the temperature ranged from 103"
to 104°. S- After a few days more she began to complain of pain in left chest and
shoulder. I saw her May Z4th, in consultation with Drs. Judy and Sharpe, and we ^reed
lo aspirate the left chest; over four pints of fluid were removed; two and one-half pints
were fair serum, but the last one and one-half pints had some purulent appearance.
During the next sis weeks the patient was aspirated several tiroes, and over ten pints of
sero purulent fluid was removed at these various tappings. At this time a thoracotomy
was decided upon. The patient was taken to the Good Samaritan Hospital, and with the
aid of Dr. French, with the house physicians, Drs. Buel and Schooifield, I opened the
chest and let out over four pints of pus, the cavity was thoroughly washed with a sat-
urated boracic solution, and the usual draini^e and dressing applied, the case was left in
Dr. French's care. The flovr of pus was considerable for a week, after that time the
boracic irrigation was follov^ed by washing the cavity every day with Peroxide of
Hydrogen. The quantity or pus rapidly dimmished, the patient gained in strength and
w«ght, and in about four weeks more came back to her Kentucky home. Her husband
continued washing the cavity with both the boric solution and Hj Oj until September
lath, when I again dooked after the case (or a week, preparatory to closing the wound,
tMit as there was still an ounce or so of pus passing per diem, it was thought advisable to
continue the Peroxide a while longer. This was kept up a month, when the quantity
discharged was not more than one-half ounce a day, but to shut off this drainage for
twenty-four hours wi. uld cause an elevated temperature and general septic symptoms;
at this time a i to 4000 bichloride solution was substituted for the boracic solution, the
Hf Oj being continued, a slight bloody discharge was thrown out for a few days, but
lessened gradually, until Novembers, when I washed thecavity witha 1 to 5000 bichloride
solution, followed with the Peroxide of Hydrogen for a few days, and let the wound
heal without any unpleasant symptoms. The chest was measured during February,
l8c|3, and at auxiliary, mammary and ensTform levels, the left scmi-circumferencc was one
inch less than the right. The PeroKidc of Hvdrogeti certainly aided very materially in
arresting the suppurative process. Marchand s pure Peroxide of Hydrt^n was ued
with but little dilution.
AN INTERESTING CASE OF EMPYEMA WITH SPECIAL
REFERENCE TO THE USE OF PEROXIDE OF
HYDROGEN.
By H. F. BROWNLEE, M. D., of DANBUttv, Conn.
(yabW^hsd, by New Engiarui Medial Mimlhly,}ane, iSga.)
This case is interesting in many ways; namely; the length of time which elapsed previ-
ous to diagnosis, the degree of exhaustion present at that time, the amount of pus evacu-
ated, and finally, the perfect and rapid recovery of the patient.
Previous to his sickness, this patient was a strong healthy man of about 30 yean of
age, but who for a few years paat had indulged in raSier frequent dissipation.
AboutDec. zothhe was suddenly taken verysick. The attending physician diagnosed
pneumonia and began a vigorous course of treatment which he continued for (our weeks.
The pneumonia did not resolve but the attending physician continued diligently in his
efforts to bring about resolution and at Che time I saw him first, over (our wedts aftiT
the beginning of the attack he was supplied with (our glasses of medicine with instructtom
to take a teaspoonful of each every hour. Upon examination 1 di^:nosed empyema and
demonstrated it by the introduction of a hypodermic needle.
AC this time the patient was in a condition of extreme exhaustion; temp, 105. pulse
hardly perceptible, respiration 48. I had him removed at once to the Danbury hospital; a
small amount of ether was administered and a resection performed, removing about an
inch of the sixth rib in the axillary line. An opening was then made into the pleural cav-
ity and two gallons of pus evacuated. I did not know the maximum amount o( pus
ever evacualed in a case of this kind, but 1 can hardly conceive o{ a greater amount bb-
ing contained in the pleural cavity of an ordinary man. The cavity was washed out with
Thiersch's Sol. and two large drainage tubes placed in the wound. The patient tiecame
quite cyanotic during the operation and required very active stimulation for several hoars
afterward.
So much for the case itself, now a (ew words in regard to his treatment and courseot
recovery. For two weeks the pleural cavity was washed out every day with Thiersch's
Sol. The patient slowly improved but bis temperature continued to rise every eveniiq;
toio3orto3. I theasuhstitutedaSol.of Hydrarg. Bichloride 1.5000. This was us«i abwK
a week when a very active salivation presented itself. During this time the tempentute
did not run so high but still continued at about 101 to loij in the evening. I then b^an
washing out the cavity with Peroxide of Hydrogen and if I had done this before I would
certainly have gained considerable time. I used Marchand's preparation, (nil strcngtb,
putting in a considerable quantity of it with a small syringe, then allowing it to escape
and finally washing it all out with a weak Borated Solution.
From this time my patient began rapidly to improve. The temperature fell to aIniMt
nothing, rarely exceeding ggi at night, tn two weeks from this time the discharge had
entirely stopped and I was able to remove my drain^:e tubes, the wound closing in a (ew
days. He gained rapidly in strength and in eight weeks from the day of operation hewaa
able to return to work.
I can not say too much in praise of Marchand's Peroxide of Hydrogen (Medicinal)
in the treatment of this case. It kept the pleural cavity so clean that there was hardly
any septic absorption and finally prevented all formation o( pus, the discharge ceasing
entirely in two weeks from the time I began its use.
THE VALUE OF PEROXIDE OF HYDROGEN IN THE
TREATMENT OF CHRONIC GONORRHCEA,
ILLUSTRATED BY A CASE.
Bv WILLIAMS ROBERTS, HospiT.u. Steward, U. S. Akmv, ri.ATTSRimuH
Barracks, N. Y.
(PubUahed l.y Th,Jo«r»<il o/lk^ AmiricaK Mtdiial Aaocitlhit of Chicago, IIL, April .^j, 1891.)
Duri.ig the past few years, the many articles on new drugs in the treatment of gon.
orrhcea leave nothing to he desired in this way. The present arilcle contains nothing
new, but simply gives ihe history of a case of chronic gonorrhcca arrested by the use of
Peroxide of Hydrogen — a drug that is "going the rounds," probably to be discarded by
reason of its being so unhandy and so little understood.
The following case might serve to illustrate the value of I'ercpxideof Hydrogen, when
used under conditions favorable to the preservation of the drug.
J. H., citiuen, age S3, contracted a gonorrhcea March ao, 1S90, and received the usual
orth(>dax treatment by internal medication up to July 7th, 1B90, the dace at which thepa-
tient came under my observation, I found a subacute gonorrhtEa, which was Bomewhat
relieved by urethral injections, including the iodoform et tannic injection of Dr. Otis,
On August 15th, 1690, the patient complained of difficult micturition, and upon ex-
amining the urethral canal. I found the following condition.
Size of urethra at bulb, Xo. 32 French; 4 inches from meatus,nNo.ii5ticture, meatus
contracted to No. 20.
The constriction at the meatus was relieved by incision, and the stricture readily
yielded to gradual dilatation, and on August 31, 1890, a No. 31 sound was passed without
pain. On September I, lSQO,an examinationof the urethralcanal showedthepresenceof
a smalL ulcer at the side of die old stricture, and stimulating injections were ordered —
without, however, reliewing Ibe "morning drop," This drop I examined microscopically,
and found pus and mucus corpuscles, with small gonorrhojal threads.
On December 10, 1890, 1 again examined the urethra, and found ihe conditions about
the same, I had tried the whole list of anti-gonorrhceal remedies, including the medicated
urethral bougies and the passage of steel sounds, and was somewhat puzxled to relieve tiie
obstinate form which the disease had assumed.
On January 26,1891, 1 commenced the use of Marchand's Peroxide of Hydrogen, 15
vol., and "glycozone," with the following results: Two drachms of a mixture of R. Peroxide
of Hydrogen, oz. Ss. aqua, oz, iss, M., wasusedtodistendlbeurethra, and held for thirty
seconds, then allowed to escape. Thedecompositionof the Hg Og was very active, show-
ing the presence of pus. I then injected I drachm, which was allowed to remain in the
canal two minutes. I repeated this procedure t. i. d., and at bedtime injected one drachm
of "glycozone," This treatment was pursued up to February 9, i8gi, when there was no
discharge, and the patient declared himself cured.
I had watched this case with greaC interest, for it was Ihe most obstinate one I had
ever seen in notylelding to someone of the many lauded cures for chronic gonorrhiea.
During seven months the patient had been under constant treatment, to find that a three
weeks' course of treatment by Peroxide of Hydrogen terminated the case quite saliafac-
The above data might naturally turn the reader's thoughts to the nature of Ihe reme-
dial i^E^Qt thai succeeded where all others had failed.
The Peroxide of Hydrogen was that prepared by Cbas. Marchand of New York, The
chemistry of this compound together with the pathological conditions it may be applied
10, 1 win leave to the many advertising agents and will simply stale Ihe care with which
Ac preparation should be preserved; fur there are factors which utterly destroy the
medicinal properlies of this valuable agent.
PEROXIDK OF H\'riROGEN AS A DEOT>ORlZER, IN CAN-
CER OF THE UTERUS. Bv GEORGE w. KAAN. M. IX.
(Published hy the Jiai/au Mvdical and Surgital ytmrnal, April 7. iSga.)
The value of peroxide of hydrogen in washing out sinuseti and abscess cavities, has
led me to use it recently as a vaginal injectian in cancer of the uterus; and with gratifying
My cases have been few; but in each the distinctive cancerous odor was noticeable
about the patient before the use of the peroxide of hydrogen, and absent afterwards. In
one out-patient case the fetor was so pronounced, that the air of the room seemed
saturated with it, the moment she entered. When 1 last saw her in making an examination
no odor was percqitible a foot from the vulva, and only slightly so close to it. Inthiscase
she had used the injection the night before, and a cancerous mass as large as a man's
fist, hangs in the vagina, within two inches of the vulva. This case has had palliatrn
treatment in the hospital, by curretting, Faquelin's cautery, and chloride of zinc applica-
tions. When she tirst came to me the disease had extended Over the whole anterior
vaginal wall; since then the peroxide of hydrogen has been used, and the anterior wall B
clear. It seems to me that the injections have had some curative action.
Further observation, of course, is necessary, but bearing in mind what Sir ^leDctr
Wells says of cancer and cancerous diseases, ttiat every thing in relation toit is so impor-
tant that nothing should tie thought a triRe, and my material being limited, I venture lo
state the facts as they appear to me in this case.
Regardless, however, of any value it may have as a curative agent, its use as a dnv
doriier, and this without substituting another odor for the cancerous one, makes it of
inestimable worth in adding to the comfort of the patient, where palliative Ircatmcfll
alone is all that remains.
The method of using has been to take atmut an ounce of the peroxide ol hydrcfOi
and an equal quantity of water, warmed by being placed in a pan of hot water, and
injected through a soft rubber catheter, so thai the injection shall be sure to reach the
back part of the vagina. Such an injection once or twice a day tias been sui^cienl.
PEROXIDE OF HVUROCJEN AS A LOCAL APPLICATION IN
RHUS TOX POISONING.
By DK. N. H. HAIGHT, Oaki.a:
I-ublished by The llomorpalhk Xdvs, of St. Lo
i. Mo., July, i8i)l.
May 20th, 1891, ] was called to treat a young lady who wa>^ suffering frOm llM
effects of poison oak. She had been suffering for nearly a week, and had tried erery
thing that friends had recommended, but conlimied In grow worse. The left aide of
her face was so badly swollen that the eye of thai side was entirely closed and she WM
suffering intense itching and pain.
I have never heard of Peroxide of Hydrogen being employed in snch cases before,
but not feehng salisfied with the treatment that I had used in the past, I decided lo ex-
periment on this case. I used Marchand'5 J'eroxide of Hydrogen (medicinal), feeling
sure that it wpuld reduce the inflammation, and by so doing, it would naturally allay
the itching. I used in the folloM-ing proportions: Peroxide of Hydrogen, j part; dis-
tiUed water s parts; applied lo the affcotod pans every hour. I also gave internal treat-
ment of croton tig. aoo. The next morning I called to see how the case was progress-
ing, and found her very comfortable, the itching and swelling being very much less. 1
continued the same treatment, and on the fourth day the case was cured. On another
case I used lis Og i part, tincture grendilla robusta 2 parts with equally good results
but no better. '
MEDICINAL VS. COMMERCIAL PEROXIDK OI-' HYDROGEN.
Sali\a, Kas., Au^h
Tot
a Editc
THE Medical Herald, St. Jos
[, Mo,:
Professional indiiference and professional inactivity are probably the iwo greatest
enemies to our individual progress in the profession. Whereas cultivation will alone fit
ua individually with that broad-guage knowledge, the practical appreciation of which
marks, with lasting effect, the progress to success. Hence, earnest interest aad labor
are essential requisites, if we would learn lo dLscriminate between the opportunities pre-
senting, lest we cultivate a Howerless plant or we find weeds instead of roses when we
kx)k for success. This is aptly illustrated by the course pursued with regard to the
selection of remedial agents by so many of us in the profession, from time to time, and
probably in no instance more forcibly than in the use of Peroxide of Hydrogen,
(Kg Oj.) In this connection, I feel it but a personal duty to the profession to record
my own experience with this agent, having for several years made use of Peroxide of
Hydrogen in suitable cases (/. f. chiefly where pus formation was found), with very
varying results. Like most of my brethren, I took it for granted that Hj Oj was the
same, so long as it was made by our leading manufacturing chemists, and consequently
paid noattention as to the effects of special brands, since 1 felt confident that my drug-
gist was handling only the products of tirst-clasa manufacturers, and could distinguish
between the "Commercial" and "Medicinal" articles. The result being that I was net
itnpress^l with anything like an absolute confidence in this agent to anest pus formation.
It was not till in October, iSgi, when in attendance at the annual meeting of the Mis-
sissippi Valley Medical Association in St. Louis, that in a personal interview with Dr.
Charles Marchand, of New York, relative to the product of his manufacture, that I de-
cided to give this agent another fair trial, and watching the effects carefully with refer-
ence to the different makes in the market. This upon the avowed assurance of Dr.
Marchand, that there was a most striking difference in the result of using the product of
different manufacturers. After almost another year of numerous trials and careful,
accurate observation with a number of different makes in the market, 1 am prepared to
confidently endorse all that is claimed for the superiority of Marchand's make. I have
med three different products alike in abscesses of almost every description, ultera, gan-
gTSne, cancer, endometritis, specific vaginitis, diphtheria, etc.. etc., and in each and
every instance Marchand's preparation proved above all, not only the most effectual,
but In every way a tnost satisfactory agent for arresting pus formation, and as a non-
irritating antiseptic for general use. Therefore, I most earnestly counsel my fellow
co-laborers in the profession to be particular in specifying Marchand's Peroxide of Hy-
drogen (medicinall whenever this agent is called in use by them.
W. B. Drwees, M. D.
RETAINED NASAI. SECRETION OR SYFHII.nTC
RHINITIS?*
ByC. E. PERKINS, M. D-. Sandiiskv, O.
Published by the Medkal S
'i-'ioi Chicago, 111., Oct.,
e and the
a patient to
k
Few cases of acute catarrhal rhinitis are Buffitiently
consult a physician. When such cases occur Ihe symptom
difficult.
February 7, a 30-year-old umnarried woman, with negative family history as 10
tuberculosis, rheumatism or lues, consulted me. There was no evidence of lues. The
Ktient had an attack of measles in iSgl, from which she and five other members of the
nily recovered without results of any kind. Up to the commencement of thistroubk
she had been exceptionally healthy and robust, having never required Che services o( a
physician. 1
In the latter part of October last she was taken with what she considered an ordh ■
nary cold. There were the ordinary symptoms of acute catarrhal rhinitis, viz.: malaise, J
dtyness and heat of the nose followed by discharge, etc , but she had in addition to all 1
these a severe neuralgia on the right side of the face, which persisted for about a month. 1
Early in December complete stenosis of the right side of Ihe nose developed and the
left was partially occluded. At this time there was a swelling across the nose, frontal
and nasal paiiB, and slight epiphora, and there was very little running from the noae
and that of a watery character. About these same symptoms continued until just before I
Christmas when she consulted her physician. I am quite certain that he considered the J
case as one of nasal syphilis, for he prescribed mercurial inunctions and insaAUtMl I
iodoform daily. She continued under his care for sis weeks. Atone time in Jann^ I
she had a hoarseness for one week. The right nostril continued occluded, and tbeleft I
became completely so, although he was adopting rigorous anti-srohililic treatment. I
Not making any improvement she eonsulted me on February 9. 1 found her weak and
Hn.-Emic and somewhat emaciated. There was complete loss of appetite, and swetliog,
redness and pains across the nose.
These pains were so severe as to interfere with sleep; there was complete at e u o ai t
of both nasal passages which caused the characteristic voice of nasal occlusion. Tbit,
upon inspection, appeared to be due to thickening and infiltration of the turbiiwKd
bodies and septum; they were in contact about one-fourth of an inch from the anterier
nares. Having benumbed the parts with cocaine. I introduced a probe wound with ni-
ton, beyond this point of contact and brought out some cheesy matter of disagreeable
odor. I was unable to get a thorough view of the nasal cavities at that time, sol
directed her to return on the following day; then I found the oedema somewhat en
sided, and saw that there was a polypoid enlargement of the middle turbinated bodi
which acted as a valve to imprison the decomposing material.
This I removed with a cold wire snare, and thus opened up a tegular cavity on cai
side, from which I removed at least an ounce of foul-smelling, cheesy pus. I might ai
that this accummulation was above the middle turbtnateds so far as 1 could m^wouL
As the parts were thus opened, and the discharge was enabled to make a
rise, by running down into the throat, to a very distressing nausea. This I sueceeded
in relieving by daily removing these secretions and spraying the nares with a sohil '
of Peroxide of Hydrogen ('"Marchand's") one to four of water, and a mixture, bl
internally, of pepsin and bismuth. I also prescribed champagne. Under this tr
ment the patient soon began to improve. She regained her appetite, the s'enosis
elieved, fcelor stopped, ard she began to gain in flesh and strength, and on March
1 pennitted her to go home, some ten miles, to reporl occasional 1)-; she
improve until March 34th when she returned complaining of obBtruclion in the
nasal cavity. Then i removed the last bit of decomposed mucus, which had be
very much hardened; since which time she has remained well. I examined her t
26th and found the nasal cavities as nearly normal as we are accustomed to se
there was no ulceration nor was there anjr perforation of the septuin, or anjlhing
gest that a syphilitic process had been going on.
■J'REATMENT OF DIPHTHERIA.
A'eoJ Bif<-ri Ihc MossBihuselts Jiemeofathic Medical Soriety.
Bv J. II. SHERMAN, M. D,, Boston.
Published by the Nev) England Medical Ctn/lle, Boston, Mass. , October, 1B92.
Intelligent treatment of diphtheria as well as intelligent treatment of other diseases
presupposes true conceptions of the nature of the disease. I take -it for granted, with
the incontrovertible evidence on the subject, that the cause of the disease, diphtheria, is
the introduction into the system of microscopic germs, bacteria. Without these germs
no diptheria. The first point of attack is the natural one where in the act of breathing
they would come in contact with the tonsils and soft palate or raucous membrane of the
nose. In mild attacks the disease remains a local one, the general system becoming lit-
tle affected. In the severe cases it extends to almost every organ in the body.
On the supposition that the disease is caused by germs, then to cure the disease,
we must destroy or antagonize them. Have we any remedy that will do this? Yes,
several; bichloride of mercury is the chief, but doses sufficient to overcome the germs
would be dangerous to the patient. We have long been looking for a remedy that
would t* a potent germ-destroyer and still one harmless to the patient. I believe that
retnedy is now found. Some four years ago there was sent to me a pamphlet treating
«f Peroxide of Hydrogen, and the author especially dwelt upon the eilicacy as an oxi-
dizer of pus. About this time 1 had a patient in the HomiEopathic Hospital under
treatment for cancer ol the cervix uteri, and asked one of the st^ of the able corps of
surgeons what he thought of Peroxide of Hydrt^n as an application to the broken
down cervii. His reply was that he did not think much of it; and having such great
ooaGdence in my friend s judgment, I relegated it to the list of the numberless nostrums
that we are Invited Co investigate. A few months ago my attention was again called to
■ this remedy by a circular of testimonials from men eminent in the profession, and from
All schools of practice. These men bad proven it tobe a safe and certain germicide. I
sent for a half pound bottle of this remedy and waited for a suitable case on which to
test it. It soon came. On August 29, 1891, 1 was called to Mrs. B — , Athens Street,
jm unhealthy locality, with cesspool connecting with street sewer djrectly in front of the
house, and the street a very narrow one. Found my patient in bed with history of three
.days' illness, fever, malaise, sore and swollen throat. On looking into the throat I
found tonsils, uvula, and soft palate covered with the characteristic diphtheritic deposit,
and portions of it assumed that dark hue so characteristic of fatal cases, and almost
certain to be followed by the septic fonn of the disease. There was much swelling of
the sub-maxillary, sub-lingual, cervical and parotid glands. Deglutition was accom-
plished with great difficulty, a considerable portion of any liquid swallowed returning
through the nose. There were also prominent laryngeal symptoms, croupous cough,
etc, showing that the disease had already invaded the larynx. From previous experi-
ence in such cases my prognosis was unfavorable, for such cases are generally fatal even
in good constitutions, under which head this patient could not be classed; her general
I by spraying the throat with Mareh-
means of a hand atomizer with han'
rubber altachtnents. as metaliiL- ones are oxidized by the rtmcdy. The effect was ini-
mediately apparent on the diphtheritic deposit. I could see dissolulion of the
membrane about the thin edges, the fibrinous portion contracting into a smaller com-
pass. The patient complained however of an extreme smarting sensation in the Ihrrxt
so that I felt obliged to dilute the peroxide with an equal quantity of water which did
not seem to mattrially impair its efficacy. These inhalations or rather sprayings were i
repeated every two hours, and the time occupied at each seance from five to ten minutes, j
The dark necrotic condition haO changed in twelve hours to the more common grayish- I
while deposit. From this time on there was a gradual diminishing of the cxudatjoo, 1
although there was a persistent tendency to re-appearance of the membrane after it tad I
been removed. I'he only internal remedies given were arsenicum, bichromate of potash,
and glycoione. The arsenicum (or the general condition of the system, the bichromate
for the croupy or laryngeal complication, and the glycozone to destroy the bacteria, the
ptomaines and leucomaines that may have found their way into the stomach, alimcnlaiy
canal, the absorbent and circulatory systems. It was five days before the throat was
free from diphtheritic deposit, and some eight days before the glandular swelling had
subsided. There was but a remnant of the uvula left after the sloughing of[ of tin
membrane, and a loss of voice from the fourth to the fifteenth day. The patient ira*
greatly prostrated fl'om the first, and rallied rather slowly under the use of concentrated
nutriment and mild stimulants. Un the whole, considering the gravity of the case, the
result was better than I have before witnessed in similar cases.
Another case worthy of mention In this connection is the following: On March the
31st, 1892, was called up very early in the morning to see Master Terrance V. Freeman,
aged three years and three months. The father told me the child had been ill for about
a week with what he and his wife considered an ordinary cold, but soon after midnii^
of the present morning he was seized with a distressing croupy cough. On visiting the
little patient 1 found the characteristic croup symptoms were apparent. I made an t%~
amination of the throat and found both tonsils covered with diphtheritic membiane.
^fy prescription was bichromate of potash lirst decimal trituration in half a glass of
water, and carbonate of ammonia, one drachm in four ounces of cinnamon water. These
remedies were given in alternation every one and one-half hours, and the throat was
sprayed every two hours, night and day, with equal parts of Marchand's reroxic'sor
Hydrogen and water by means of a hand atomizer with hard rubber attachments, Thk
line of treatment was persisted in with alternate remission and exacerbation of the synp-
toms for five days, when the disease seemed under subjection, end convalescence secUTCQ,
which continued uninterruptedly until the tenth day, when I discharged the case. TM»
child was naturally a frail-looking child, though it showed a remarkable vitality throogh
this severe and protracted disease. It was given from the lirst all the nutritious ftMd It
could be induced to take, consisting mostly of milk and bnvinine. That it was dipb-*
theritic croup was evidenced by the membrane detached and coughed up at differcM
times during the disease. On one or two occasions the child nearly suffocateii by the
loose membrane being drawn into the lBr)'nK or trachea, and subsequently expelled. U
is my opinion that this child would have died had it not been for the Peroxide of Hy-
drogen. It may seem a difficult thing to spray a child's throat effectively for five wto-
utes at each seance, as the child will not voluntarily hold its mouth open. 1 ovciouH
this difficulty by putting a fork-handle between the teeth on one side of the moulb, Hid
having it held by an assistant standing behind the child and holding its head in pouliee
at the same time.
1 have used this remedy. Peroxide of Hydrr^en, in several other cases of difA*
theria of a mild tonn, which would not be of interest to report as they all made sati^-
toty recoveries, and probably would have under usual treatment.
What is Peroxide of Hydrogen? "The name hydrogen dioxide expresses Its ..
position, and its formula H,Oj represents this name. Hydrogen monoxide. li,0, ..,
under certain conditions, be made 10 combine with a second molecule of oxj^
gen, Ihe result being a water-like liquid. EIjOj." This agent is one and one-
more potent as a germicide than corrosive sublimate and perfectly harmless. It is
adaptBi lo all zymotic diseases and suppurative processes. It will follow a pus sinus as
a ferret will follow a rat, and be sure of destroying the pus and germs.
t alluded to this remedy some months since at a meetiog of the Boston HonKsopathic
Medical Society, when the subject of Gonorrhixa was under discussion, and the editor
of our much valued Gazette remarked that th»e was scarcely anything in medical liter-
ature concerning it, and that what was known about the remedj' came chiefly from the
manufacturer. This caused me to look up the subject, and I hnd an amount of pub-
lished testimony altogether to voluminous to be quoted.
MEDICAL DKPARTMF.NT SURGEON-GENERAL'S OFFICE.
Ih,„l.,unri.
: of the First Brigade Michigan State Treops.
Tkcumsch. Mich.. Sept. 15th, il
Cmas. .M*RCHANn, N, Y,:
Dear Sik — I promised you I would write you further about the I'eruxidi
drt^[en (medicinal) manufactured by yourself.
1 have cured a great number of cases of throat diseases with it, and oni
severe cystitis in an old man of 70. which I had treated with mild solutions of '
sublimate for nearly two weeks; he was benefitted a little. I then used one-ha
of your Peroxide of Hydrogen to a pint of boiled and strained rain
and washed out the bladder thoroughly with this, — the man got up next day
Up every day after that, was well in three days with only the one injection or 1
it is worth its weight it used only in cases of cystitis.
C. M. WoOdWARU, Surg, (jeneral M. S.
THK PKROXIDE OF HYDROGEN (MEDICINAL); .AN INDIS-
PENSABLE WOUND STERILIZER.
BV GEO. H. I'lEKCE, M. D., hro.iklvn, >
(Published \yj New Ettgland Mediral Moalhly. Noven
2-)
Probably the use most frequently mode of this preparation, is in the cleansing of
I pus cavities, and suppurating surfaces. Any trace of pus remaining in any recess which
' an ordinary douch will not reach, is at once sought out by the peroxide, decomposed,
and brought to the surface, in bubbles of gas. Il is useful in cleansing off ulcers,
sloughs and gangrenous tissues, chancres, diphtheritic patches, etc., and in cleansing
SDUses, and suppurating cavities, such as the pleural in empyaema, and theuterus where
there is putrid discharge, and in cleansing abscesses where either puncture or free incis-
I ion has been made, it is invaluable, clearing out the pus as nothing else can do. There
L is one class of disease where its local action as a cleanser must be seen to be appreciated;
I and. that is as a disinfectant for foul gangrenous growths. In a case of extensive epi-
theliomia of the face, where only pillialive raeasores were of use, I found the Peronideof
) Hydrogen a very (lodsend. This case was one of the most foul 1 had ever witnessed.
I Wben I first saw il. the odor from it was so great that it filled the house. It was cov-
cred with a cloth into which the discharge had accumulated, thta adding a greater bulk
of fetid decomposition; and to add to the horror, for such it was, upon removing tiK
clolh, the aurface was swarming with maggots, as lai^ and active, as may be found in
a iieap of decomposing garhage, and not only on the surface, but they extended deeply
in sinuses below the ear where it was impossible to reach them, except as they would
come to the surface. My first impulse was to invoke Beelzebub for some patent ex-
tcrminatar, but finding myself left to my own resources, I set about bringing destruction
as best I could. As time was of some moment. I removed what 1 could reach with dress-
ing forceps, then douched with bichloride, i-iooo, then with Peroiide of Hydrogen, 15
vol. strength, rinsed this off with warm water, and douched again thoroughly, with per-
mauganate of potash solution, and finally dusted the whole with beecbwood charcoal-
which, in addition to acting as an absorbent to the gases, made an appearance very
much to be preferred to the ordinary gangrenous appearance. I ordered the cloth to be
left olf entirely; first, because it only added an additional fetid surface, and second, be
cause the growth was very vascular and would bleed easily on being disturbed. It was
dressed morning and night, and henceforth was kept almost entirely free from odor.
The same routine was gone through with each day. First, Peroitide of Hydrogen,
which was applied by pouring it directly from the iolt/e in Tfliich if ^amc, an alisorbent
cotton held by dressing forceps, so that it dropped directly on the growth; when im-
mediately a white foam would cover the surface, from the disint^ration of pus, gangren-
ous shreds, blood, etc. Second, rinsing off with warm water, then with pennanganaM
of potash sol, gr. ij., cupful of water, allowing it to drip from a wad of cotton over the
surface. Third, dusting with charcoal and leaving it uncovered. An immense lot of
Peroxide was consumed in (his case, being purchased in \ lb. bottles, six at a time. Thii 1
seems to me a very effective means of keeping clean these foul discharging growths of
the carcinomatous class; the Peroxide and permanganate, being a most thorough disin-
fecting combination; and if employed tn any case of cancerous growth, where palliathn
alone must be relied on, will mskethat life and the lives of those closely associated with it,
more endurable. One important tact remains in regard to the chemical properties oTlbe
Peroxide, To be effectual, it roust be kept from the air. lightly corked, in a dark bottle,
and in a cool place. It must be used directly from the original bottle. Do not pemlt
the druggist to pour from one bottle to another when dispensing it, else the oxygen will
escape, and it will be powerless. If when using, the white foam does not appear, it b
because the preparation has lost its strength, and is alisolutely of no use, of no more
value than so much water, Hj Og must be present. It is the additional atom of O
combined with the H, thai does the work, by giving up that nascent O for the purpM
of oxidation. The strength should be 15 volumes. The preparation which I always in
is Marchand's Peroxide of Hydrogen (medicinal).
."JI.VCOZONR IN THK TREATMENT OF CASTRIC
TROUm.E,
Editor of liociors llWify.-
Deab Sir, — I received your paper this morning and was pleased to see a no
glycozoue. I have used it recently with great success in two cases of gastric I
when almost all the useful remedies had failed, and with the happiest risults. '
perfect antlfermenl. relieving all the distressing dyspeptic trouble and i ' '
better than all the pepsins I have ever seen, Respectfullv,
OLCVER b. NOSTRANU, M. D.,
Cincinnati, O.. Oct, 21. :Sg2, *86 West Founli St.
Jlcadin the Section of Laryngology and Otology, at tlie Fotlv-lhird Annual Mtedng
of tkc American Medical Associalha. held al Detroit, Mich.. June, iSqs.
{Abilract.)
Hv WALTER B. JOHNSON, M. D., of Pateeson, N, J.
Sargeon to the Palrnon Eye ami Ear Infirmary.
(Published by iiie_/iiu'-H,i/ of the American Medical Association, October 2glh, iSga)
The peronidc solution may be used advant^eously in the treatment of mastoid
disease after an incision has been made. The action of the remedy upon bone denuded
of its periosteum, and even upon carious or necrotic Ijone, is unique; it rauses a disinte-
gration of the molecular particles and they are gradually subdivided and carried away
in the frothy product of the chemical action, until a healthy surface appears upon which
the solution seems to have only a beneficial effect. The action of the solution upon
dead bane can be readily demonstrated by placing a small portion of necrotic bone in it;
the bone in a short lime will begin to disintegrate and continue to do so until it is en-
tirely divided into very minute panicles.
In some of the cases of mastoiditis treated, in which the denuded surface was very
extensive, in from three to six weeks the bone would be in a perfectly healthy condition,
the discharge of pus controlled, and the subsequent closing of the wound, when allowed,
occurred rapidly and was perfectly satisfactory.
In one of the cases, in which for three years any attempt 10 allow the closing of
the sinuses would be followed by an enacerbalbn of the inflammation, the carious con-
dition was relieved and the opening allowed to close after two months of treatment.
The treatment is very simple and consists in syringing through the opening and
into the meatus with a small glass syringe a sufhcient quantity of the fifteen volume solu-
tion, at each sitting, to render the pus thoroughly aseptic, then pacldng the ear and the
wound lightly with strips of sheet lint or gauze thoroughly soaked in the same solution,
^eat care being taken to allow the wound to close, although the packing must not be so
introduced that it will prevent the free exit of any pus which may be formed during the
interval between the dressings. The external Incision should be made ample and if the
packing does not prevent the opening from closing during the progress of the treatment
it niust be reopened with the knife. Glycozone has been suggested for use in keeping
the wound open, being used instead of the peroxide in the dressing.
The result of this line of treatment which has been followed in a considerable num-
ber of mastoid cases, has indicated the possibility of a degree of conservatism in the
treatment of mastoid disease which is very desirable.
All the cases treated have done well, no deaths have occurred and in no case was it
considered necessary to scrape the bone or to remove any portion of it, while the period
of time necessary for the wound to assume a sufHciently healthy condition to render it
advisable to permit it to close, did not seero longer than the time which must ordinarily
elapse after the operation for thoroughly scraping the mastoid, and was much shorter
than the time required before the wound produced in chiseling the mastoid could possi-
blj' be allowed to close.
Special care should be taken to keep all the applicators or sprays, used either with
tlie peroxide of hydrogen solution or glycoione. perfectly clean, especially in case of
miKtures of glycerine and peroxide which should be made fresh every second or third
day to prevent the possible formation of formic acid; only silver, hard rubber, glass or
porcelain should be used for measuring purposes.
It care is taken to properly keep the solutions, they arc perfectly harmless and cal-
culated to be of inestimable benefit to all who use them.
[THE OPF.RATIVE TREATMENT OF FISTULA IN ANO.
Bv LEWIS H. ADLER, Jk,, M. D.,
■I ProfinBr «f Diitases oflhtRtcllull, Phitudtlfhia Poljvlini. .<mi ColUg' for
Graduates ■'« Mtditine.
Read before the Fhil. t'ounly Medical Socieiy. November 23d, 1892.
iteil from the Iiileraaliaiui! MldUal Jifagaiiiur (or October, iSga.
-r the (iperalion o[ (istula i'» aiio, I am in the habit of packiog the wound wilk
BdoFonn gauze, which is left undisturbed for twenty-lour hours. This is done lo pK-
Tent subsequent hetnorrhage. A pad of gauze and cotton and a l*-bandage are not
applied.
The subsequent dressing of the caiie should be daily attended to b}' the surgeon him-
self. The parts should be kept perfectly clean, and the wound syringed with peroinde
of hydrogen (Marchand's). carbolic acid solution, etc., alter which a single piece of
iodoform gauze laid between the cut surfaces of the wound will be all the dressingir-
In the aflcr-lrealnient of these cases 1 have seen the healing process greatly relardcd
by the excessive paokitig of the wound with lint, or delayed by the undue use of the
probe. Such interference is to be avoided.
If the granulations are sluggish and the discharge Is thin and serous, it will be well
to apply some stimulating lotion, such as peroxide of hydrogen, or a weak solution o[
copper sulphate (two grains to the ounce).
The surgeon should be on the watch during the healing process to avoid any b
ing or the formation of fresh sinuses. Should the discharge from the surface of the
wound suddenly become excessive, it is evidence enough that a sinus has formed, and
a careful search should be made for it. Sometimes it is under the edges of the woand
that it commences, at other limes at the upper or lower ends of the cut surface, and
occasionally it seems to branch off from the base or the main hstols.
Pain in or near the seat of the healing fistula is another symptom of burrowing, 1
when complained of, the surgeon should carefully investigate its cause.
After an operation for fistula, the patient's boweia should be confined for three or
four days, for which purpose opium is usually given. At the end of this thncllM
bowels may be opened by the administration of a dose of castor oil, and so soon tts the
patient feels a desire to go to stool, I am in habit of ordering an enema of warm «
lo be administered, which has a tendency to render the faeces soft and fluid and hi
to make their passage easier, 'i'he patient should be kept in a recumbent posture nntQ
the fistula is healed and Until the bowels are moved; the diet should be hquid such as
milk, beef-lea, and broths. The time required for a patient to recover after an oper-
ation for fistula in ane varies with the extent of the disease. In an average case it wiB
be necessary to keep the patient in bed for two weeks, and confined to the house fora-
couple of weeks longer.
ABSTRACT FROM A TREATISE ON DISEASES OF Tiflft:,
RECTUM, ANUS AND SICMOID FLEXURE.
Bv JOSEPH M. MATHEWS. M. D.
Prof. 0/ Principlti and Praeticii of Surgery, and Clinical Lfcfurrr on Distaiii afHit
Rttlum; KtalHcky School ef Mcdicinr, LouirviUe, A'r.
operation is performed. Dr. Mathews writes as follows;
Pj^e 188,— After'
I then syringe the
5000), ■■
ivity out freely with a
as it will hold. After the expiration of twelve tiours, 1 withdraw the iodoform gauze
and allow any accumulation to pour out freely. I have Used the bichloride solution
here tirsl, because I believe it to be a good antiseptic and at the same time a good stim- .
mlaat t3 the cavity. However, afterward I Eubstitate another agent — viz., Peroxide of
Hydrogen. Of course our great object in dealing with cavities of this kind are two-
fold; First, to stop suppuration; second to heal the diseased structure. For prevent-
bolic acid. Every surgeon is well aware of the fact that dangers attend the u:
bolic acid in the treatment of suppurating diseases, and the too free use of the bichloride
of mercury in large suppurative cavities might not only cause too much inflammatory
action, but also produce a general cRect upon the system which would be shown in
ptyalism. We have In a strong solution of peroxide of hydrogen a substitute for these
two without any of their attending dangers. Undoubtedly the best preparation of this
agent is Marehand's Peroxide of Hydrogen (medicinal). His fifteen volume solution
will retain active germicidal power [or many months, if kept tightly corked in a cold
place. It can be used, of course, in any strength that the surgeon desires. Marchand
has devised a hand atomizer and ozonizer for the purpose of using the agent in an easy
' The abscess cavity ia injected once a day with this agent, either pure or diluted with
water, from three to ten parts, and each time the tent of iodoform gauze is pushed
gently into the CKtcrnal opening, hut so as not to fill the cavity. As the healing pro-
cess goes on, a leas amount of gauze is used. H large rectal abscesses are treated in
this manner, the number of cases of fistula will be greatly reduced.
SOME OK THE USES OF PEROXIDE OF HYDROGEN IK
GENERAL SURGERY,
By THOMAS H. MANLEV, M. D.. Nkw York,
Published by the AViti iLnglaad Mi-Jical AfoiiMy, Danbury. Conn., Dec, 1892.
Since Marchand placed on the market, a pure, unadulterated peroxide of hydrogen,
and Morris of New York, called attention to the marvelous power of this preparation as
a deodorizer, the profession have very generally employed it in such pathological condi-
tions as will enable us to apply it directly to the diseased surfaces. In general medi-
(Hne it has been employed on extensive scale in the phagedenic, sore throat of malig-
nant scarlatina, diphtheria, and other maladies.
In surgery, it has been particularly recommended in nnn-maiignant, suppurating
L Since it has now come to be very generally known, that with very tew exceptions all
I chemical solutions of sufRcient potency to kill germs, possess such irritating properties.
I as to interfere with healthy cellular proliferation, there has been a demand for some-
I thing which might nullify germ activity, and at the same time, in no way interfere with
the recuperative enei^ in the histological elements. In a large class of cases peroxide
of hydrogen seems to provide this want.
In the Harlem Hospital and Dispensary service, the peroxide. Marchand's medicinal,
is largely employed; and, in appropriate cases, with better results, than with any other
It seeffis to possess a Special affinity for the lethal elements, in all suppurating pro-
cesses, which tend to run into chronicity.
We have largely employed it in those cases of fistular sinuses, so seriously resulting
from suppurating lymphatic glands in children and adults; as well, as in those buboes
which are sure to heal and discharge for a long time, a sero-purulent matter.
The only class of sinuses in which its Use should be employed with caution, are those
in which the listula extends, into a lesion in the osseous elements.
Id many cases, in which a long, deep rent has been made in Ihe tissues, in strumous
-subjects, in which healing processes are delayed, its employment is very satisfactory, in
effecting primary union. Now, whether it acts as antiseptic; or, by imparting Iredi
vitality to the cells, is a question by no means settled.
Wtien we use it, it should be applied in such strength as difterent cases require. In
foul smelling, copiously discharging processes, it may be used in a^ncentrated form,
-while in mDder cases, particularly in children, it should be diluted.
In my own private practice none has given roe so much satisfaction as that manufac-
tured by Chas. Marchand; and as we have seen in Dr. Squibbs' "Ephemeris." for thii
year, this preparation seems to be regarded by chemical analysis, to maintain a higli
and uniform standard of strength and purity.
INTESTINAL OBSTRUCTIONS.
DIAGNOSIS AND TREATMENT,
(Abstract from the Mfdical Kecord, July 23, 189s.)
Irrigation of Abhominal L'avitv.— As to the irrigation of the abdominal cavity,
the practice inclines toward the use of plain water or so-called normal salt solution, na-
tenths per cent. My own experience and observation lead me to believe that nuui; of ^
the complications following laparotomy can be traced directly to the. use of chemical
solutions during the operation, either for irrigation, for disinfecting the hands of Uw
operator, his instruments, or sponges. In a case where the abscess is circumscribed, it
is bad practice to irrigate, owing to the danger of infecting the general cavity. In ill
aseptic cases irrigation should be avoided. When irrigation is necessary, while the no»-
mal salt solution is best, still in some cases, I believe, this may be followed by a secoml
douche containing a small quantity of hydrogen dioxide. I have used it forserenl
years in all kinds of surgical work, and once in the general abdominal cavity; in acMC
already alluded to (the patient dying shortly after the operation, no deduction can be
drawn from it), and where pus was present, have found it in proper solution men effi-
cient and [ess irritating than anything else. In some of the New York hospitals, it tus
been used for irrigating the pleural cavity in empyema, and it has proved satisfactory.
I have been unable to find any record of a case where this compound has been used nr
irrigating the general cavity. In the letters already referred to. Dr. Senn says: "H»e
>t hesitate It
avity, bul
■used the hydrogen dioxide in cases of limited peritonitis, and should n'
it in the diffused form."
Dr. Mann says: "And I have never used hydrogen dioxide in the general
have applied it 10 the cut ends of tubes, holes in the intestines and bladder,
good results."
Dr. dement Cleveland says: "I have never used the dioxide in the peritoneal cavity.
I have used it pure in the uterine cavity, in puerperal septicemia, with excellent results."
Dr. Robert T. Morris writes; "In localized septic peritonitis, where I have oc
to expose directly the infected locality with retractors, I pour in the HgOg
strength and without any warming whatever. After allowing it to remain for a
ortwo I sponge out audrepeat, leaving the second lot for live minutes, sometimes Ml
removing it at all, but putting my game wick down into it and allowing it to be sucked ;
np at leisure by the drainage- wick. I have used it twice only in general septic peritoni-
tis. One of the cases wasan appendicitis (perforated), with the patient moribund at the I
time of application of the HgOg, 1 poured in a very large quantity, enough to bathe all
of the abdominal organs; a very little hot water was poured into the peroxide just at the'
moment of using it, 'to take the chill off.' The peroxide was then siphoned out and tht
95
patient was made very much easier by the treatment, although he finally died. The-
other patient died too. The case was one of general septic peritonitis that had gone oi>
to suppuration after removal of a gangrenous ovarian cyst. The post-mortem examina-
tion showed that the HgOg had cleaned the cavity beautifully, and, although my patient
died, I nevertheless obtained the impression that one has after such observations, that
the H2O 2 was very useful, and evidently quite harmless in itself. There are lots of
cheap peroxides on the market that contain acids, and such would be harmful." (See
article by Dr. Robert T. Morris, page 55, also article by Dr. F. H. Wiggin, page 75.)-
PEROXIDE OF HYDROGEN.
By L. C. SCHUTT, M. D., Toledo, Ohio.
Published by the Toledo Medical Compend, December, 1892.
Referring to Peroxide of Hydrogen (medicinal) Dr. Schutt writes as follows:
Diphtheria. — As a local application in this disease, Marchand's Peroxide of Hydro-
gen (medicinal), can be used full strength, but in the majority of cases it is best to dilute
it with from 20 to 30 per cent, of water. It may be applied with a brush or atomizer,
and used as often as the severity of the case may require.
Pitting of Small-Pox. — The topical application of peroxide of hydrogen or glyco-
zone is very beneficial. It allays the irritation of the skin and lessens the pitting and
force of the disease.
The local application of the peroxide in hay fever has proven very beneficial when mixed
with an equal quantity of water and glycerine. It should be used at the very outset of
the disease.
As A Cosmetic. — When applied to the face it will make imperceptible a dark downy-
growth on the face when the hairs are numerous and fine and cannot be removed by elec-
trolysis. It should be applied several times a day with a camel's hair brush, until the hairs-
are thoroughly whitened and after that as often as necessary. The grease which adheres-
to every hair should be removed by applying a solution of powdered borax in water.
In deep cuts and ulcers you will find the greatest benefit from the use of peroxide of
hydrogen.
I will report one case in which very decided benefit was obtained from the use of this-
preparation.
Mr. P. O. H., a young man 23 years old. He received an injury to his right hip,
while helping to unload a cannon. It terminated in hip-joint disease, which confined
him to the house for more than a year. Finally suppuration occurred, leaving him with
two sinuses and several openings. All kinds of washes were used but the pus kept up.
At last I commenced treating it with peroxide of hydrogen, using it pure and diluting it
with water. We used it every day for seven months at which time all discharge of pus
had stopped and the openings nearly closed. I am sure no other bactericide could have-
been used so long and with such good results, without injury to the parts or general
system.
:'1
RETAIL PRICES.
For goods delivered in New York.
1 Box containing i lb. Ch. Marchand's Peroxide of
Hydrogen, 15 vol. medicinal, i lb. C. P. Glycerine,
and I Hand Atomizer and Ozonizer $5.00
I Hand Atomizer and Ozonizer $3-50
PEROXIDE OF HYDROGEN GLYCOZONE,
(Medicinal)
U-\b. Bottle 50c H-\b. Bottle $1.00
J4-Ib. Bottle 75c JS-Ib. Bottle 1.75
i-Ib. Bottle $1.00 I -lb. Bottle 3-00
Laboratory, 38 Prince Street, New York.
Wlien \ou cunniit proiiire Ch. Marchand's preparations in ihfiir
original, unbroken packagesatyunrilniggisl.stnd money order lo
"Ch. Marchynd" at tht above address, and shipment will bt made liy
express,
■fhese remedies are put up in glass and cannot be mailed.
Should you have been imposed upon by anyone who substituted
■ npurioiis preparations inMead of the genuine ariicle, please report to
mc, so that 1 may cxpcise and prosecute such consummate fraudulent
dealers, 1 want lo protect the physician, his patients l-^ v/el\ as iny-
«e)t.
The United States Army Hospitals vsi- Ch. Marchand's I'croKide
i-ef Hydrogen (medicinal) exclusively.
LANE MEDICAL LIBRARY
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