SCIENCE REMAKING THE WORLD Brown Bros. THE FIRST OIL WELL IN THE UNITED STATES On Oil Creek in Pennsylvania. Col. E. L. Drake, shown in the picture with the high hat, began work on this well May 20, 1859, and on August 27 of the same year struck oil at a depth of 695 feet. The well produced thirty barrels a day for a year OTIS W. CALDWELL Ph. D* Director of the Lincoln School of Teachers College, and Professor of Education, Columbia University EDWIN E. SLOSSON Ph. D., Editor, "Science Service19 SCIENCE REMAKING THE WORLD GARDEN CITY PUBLISHING CO., INC. GARDEN CITY, NEW YORK CGPTRIGHT, 1922, 1923, BY DOUBLBDAr, PAGE & COMPANY. ALL RIGHTS RESERVED. PRINTED IN THE UNITED STATES AT THB COUNTRY LIFE PRESS, GARDEN CITY, N. Y. PREFACE DURING the summer of 1922, nineteen men cooper- ated in presenting a course of lectures in Teachers Col- lege, Columbia University. The purpose of the course was primarily to provide interesting and engaging in- formation about the achievements of modern science. It attempted to give students of all subjects an under- standing of certain types of achievements of modern science, to suggest the meaning of science in various aspects of modern life and thought; to indicate the place of science in modern, social, and industrial rela- tions. Before half of the lectures had been presented, hundreds of listeners had requested me, as organizer ot the course, to assemble and publish part of the lectures and if possible, to find means for wide distribution of the resulting volume. In my desire that the volume, when published, might benefit from the unusual style and scientific clarity of Dr. E. E. Slosson, his assis- tance was successfully importuned in the venture. Then, a gracious and generous though anonymous benefactor agreed to finance the placement of a limited number of copies of the proposed volume in libraries of educational institutions. Finally, the publishers cooperated by pro- viding at bare cost of production the first lot of copies for general distribution, depending upon later sales for their profits from the publication. The authors and the I vi PREFACE editors have contributed their services without personal remuneration, and have done this as a welcome privilege in helping to extend the achievements and underlying truths of this most conspicuous field of modern thought. Not all the lectures which were given in the course are available; also changes which are advisable for publica- tion have been made; and Dr. Kellogg and Dr. Williams have kindly added chapters upon topics of wide interest and importance. Why give such a course of lectures, and why publish such a volume? Because the citizen of our day uses modern science at each turn of his day's work. If he is a thinking citizen, he is ambitious to benefit by what he understands as scientific procedure in using facts, principles, and occurrences. A manufacturer wants his operators to possess whatever knowledge of ma- terials and processes science has produced for the improvement of quality and quantity of output. A lawyer or preacher desires factual illustrative material from the working world of science with which to make his case clear and convincing. If this citizen is a teacher of any subject or grade he deals with the biggest science need of all, for those whom he teaches belong to an age which science has made unlike any of its predecesssors. To men in industry, commerce, and the professions, it is of increasing importance that progressive workers shall have knowledge not only of accomplishments of science, but of the methods by which discoveries are made. Some thirty years ago Louis Pasteur said : In our century science is the soul of the prosperity of nations and the living source of all progress. Undoubtedly, the tiring daily PREFACE vii discussions of politics that seem to be our guide are empty appear- ances. What really leads us forward are a few scientific discoveries and their applications. And the following is quoted from a recent statement by President James R. Angell: Nothing can be more certain than that the character and rapidity of our national development in all matters which relate to industry, agriculture, public health and the preservation of the physical framework of our civilization will be dependent upon the quantity and quality of sound research which is carried on. The truth of this assertion becomes even more apparent when one recognizes the fact that every modern nation stands in relation of industrial and commercial competition with other nations, and, in the measure in which this is true, to fall behind the others in scientific development is to precipitate a trend of events which spells national depression and disaster. In other words, the price of a sound, comprehensive national life is, in these times, widespread and intelligent scientific research. Men need and desire a genuine interpretation of modern science as it appears in the home, street, and factory. They want to know its meaning in public health, in industry, in social relations, and above all in the adjustment of their philosophy to the scientific truths of the modern world. This volume is especially designed to assist the teacher of courses in general science or the special sciences by bringing textbooks up to date and suggest- ing possible occupations to young people who really need guidance in finding callings which appeal to them as fields of opportunity and usefulness. It is expected also that the public will find this volume a convenient and engaging means of catching up with viii PREFACE the progress of modern science. Every intelligent person, whatever his professional interests, has a nat- ural curiosity to know something about the new things in science, as well as in art, literature, drama, and world events. But it is not so easy to keep in touch with the advancement of science since comprehensible compen- diums of recent researches are hard to find. At the end of each chapter there has been appended a list of several recent and reliable books and articles, both technical and popular, for the convenience of readers who seek further information. The reader will notice that in almost every chapter there is given, besides an explanation of recent discov- eries and applications, some account of the efforts that have led to them and of the personalities concerned in them. This unusual feature is due to a theory of the editors of the volume that more attention should be paid to scientific history and biography. They be- lieve that one of the reasons why science is commonly regarded by the public as dry is that it has been too completely divested of its human interest. It is im- portant for the public to understand that scientific progress is not a mere series of the lucky accidents and happy inspirations of a few favoured individuals, but a long and toilsome process of investigation, hypothe- cation, and verification on the part of many workers who often follow fallacious theories and turn into blind alleys from which they have to find their way back to the highway leading toward truth. OTIS W. CALDWELL. CONTENTS ACHIEVEMENTS AND OBLIGATIONS OF MODERN rjuom SCIENCE I Otis W. Caldwell, Ph.D. GASOLENE AS A WORLD POWER 12 Edwin E. Slosson, Ph.D. THE INFLUENCE OF COAL-TAR ON CIVILIZATION 48 Edwin E. Slosson, Ph. D. ELECTRONS AND How WE USE THEM ... 78 John Mills, M.A. AN INVESTIGATION ON EPIDEMIC INFLUENZA . 99 Peter K. Olitsky, M.D., and Frederick L. Gates, M.D. OUR PRESENT KNOWLEDGE OF TUBERCULOSIS . 115 Linsly R. Williams, M.D. Louis PASTEUR, AND LENGTHENED HUMAN LIFE Otis W. Caldwell, Ph.D. 133 INTERNATIONAL PUBLIC HEALTH 150 George E. Vincent, Ph.D. x CONTENTS EDUCATIONAL VALUE OF MODERN BOTANICAL PAOB GARDENS 102 George T. Moore, Ph.D. THE MEANING OF EVOLUTION 167 John M. Coulter, Ph.D. OUR FIGHT AGAINST INSECTS 19x5 L. O. Howard, Ph.D. INSECT SOCIOLOGY 199 Vernon Kellogg, Ph.D. How THE FORESTS FEED THE CLOUDS . . . 212 Raphael Zon, F.E. THE MODERN POTATO PROBLEM 223 Charles O. Appleman, Ph.D. CHEMISTRY AND ECONOMY OF FOOD .... 247 Henry C. Sherman, Ph.D. OUR DAILY BREAD AND VITAMINS .... 265 Walter H. Eddy, Ph.D. SCIENCE REMAKING THE WORLD SCIENCE REMAKING THE WORLD ACHIEVEMENTS AND OBLIGATIONS OF MODERN SCIENCE BY OTIS W. CALDWELL, PH.D. Teachers College, Columbia University A FEW years ago at a New York City luncheon, a business acquaintance expressed a keen desire to have a conference with a Chicago scientific friend of one of the luncheon guests. He said: "Will you not telephone him and see if he will meet me in New York to-morrow ? " Thus, at 1 2 : oo noon, the tele- phone connection with Chicago was made, a conversa- tion held with the friend, and at 12:45 P-M- tne Chicago scientist took his train. At 10 o'clock next day the conference was held in New York, and at 2:45 P.M. the man of science was on his return journey which placed him in Chicago next morning, ready for his regular day's work. What an age in which to live! A science man, almost a thousand miles away, is needed for a conference. The telephone permits a brief con- versation with words so clear that the peculiarities of friends' voices are heard almost as in the speaker's 2 SCIENCE REMAKING THE WORLD presence. A modern train transports the passenger while he eats, sleeps, and writes his plans for his meeting. The necessary conference is held next morning, and the following morning he is back at his regular post. This ready and effective communication and dizzy speed of travel have become ordinary and slow, as modern science continues to work. By wireless we speak not merely from New York to Chicago or to 'San Francisco, but over the oceans — around the earth in a few relays. So rapidly is science improving com- munication that we hesitate to write of "wireless," knowing full well that what we say will be out of date, possibly, before the statements appear on the printed page. And what of human transportation? The Twentieth Century, the Broadway Limited, or the Transcontinental Express, apparently creeps along as the modern airplane above speeds on its way. A regu- lar service route is proposed which will permit the pas- senger to dine in New York or Chicago, go to a theatre, then take his airplane sleeper, and breakfast in the other city. Even the erstwhile astounding feat of a non-stop flight in twenty-seven hours from New York to San Diego has ceased to give us its early thrill, so confident are we that modern science contains possi- bilities surpassing our wildest expectations. "Twenty thousand leagues under the sea" no longer seems fanciful. "You can no more do that than you can fly," is now meaningless. "Voices passing through the air," is now so true that even we as speak to one another there may be passing through the atmosphere about you unseen messages pertaining to peace and war, love MODERN SCIENCE 3 and hate, commerce, industry, government — every topic which holds men's minds — all being transmitted through a common medium, none necessarily interfering with any other. Surely the imagery of the past seems trivial when compared with the reality of to-day. Science has successfully attacked many of the ills to which men succumb. We need not now have smallpox unless we prefer not to do the things which science has shown will prevent this disease. Typhoid, far less common than two decades ago, is so well understood and its transmission so definitely associated with un- cleanliness that we shall soon see the day when it will be not only unfortunate but not respectable to have the disease. It would now be more indecent to have typhoid than it is to have the "itch," were each person as fully in control of his own personal environment for cne one disease as for the other. Yellow fever, the awful plague of many countries, not only can be de- stroyed, but has actually been destroyed in certain of its worst centres. It is a picturesque campaign now Deing waged, one with a vision of service to the human race, to remove yellow fever from the earth. The most dreaded disease of all, perhaps, tuberculosis, is slowly but surely yielding. Though big tasks are ahead, enough is now known and proved in practice with tu- berculosis patients to give abundant hope to hundreds of thousands of discouraged people who have this dis- ease. It is but a brief time since a clear diagnosis of tuberculosis was all but a death warrant. Surely sci- ence is making the earth a better home for men. In instruments of warfare science has produced an 4 SCIENCE REMAKING THE WORLD antithesis not yet understood by men. In the World War the airplane dropped bombs within the range over which the airplane could fly. The dirigible balloon could carry heavier bombs over a longer range, but the gas which carried the dirigible aloft was highly inflam- mable, and a gun shot through the gas bag meant con- flagration and a terrible death to those who were in the balloon. But a scientist studying the sun found helium in the sun's chromosphere. Of what use to us would the sun's helium be? Then helium was found in a mineral in the earth. Helium, lighter than air, was not inflammable, was not easily affected by electric currents — thus an ideal gas for dirigible balloons. Helium, supposedly very rare, could be secured only at a cost of something like $1,500 per cubic foot, and a large dirigible balloon requires a million or more cubic feet of the gas. Then another scientist discovered that helium may be secured from natural gas and the gas be improved for domestic use when the helium is removed. Later developments will permit men now to secure large quantities of helium at a cost of a few cents per cubic foot. Thus dirigible balloons may be floated on the air by a non-inflammable, non-electrifiable gas at heights and over distances hitherto thought impos- sible. During this development, new discoveries regarding explosives have increased their efficiency, so that now it is said that a single ton of the highest explosive will, if advantageously placed, serve to destroy the largest existing battleship. Or if the bomb is loaded with the latest destructive gases, it will snuff out the life of all MODERN SCIENCE 5 the occupants of a modern city. Helium gas for use in balloons, other new substances for modern explosives and killing gases — these are instruments of destruc- tion which will completely change warfare in its meth- ods. Even modern battleships are now said to be obsolete, since none is protected against modern scien- tific bombs. Helium carried dirigibles may go anywhere and drop destructive gases hundreds, even thousands, of miles from the base of operations. The achievements of science are very great both in their number and in the magnitude of their influences. Tremendously powerful for good and for ill as are the material advantages gained through modern science, it is possible that still greater advantages may be gained through certain attitudes of thinking, judging, and acting which modern science is patiently teaching to a slowly learning human race. It is but a little while, in the comparative history of men, since those who dis- agreed too loudly with generally accepted ideas were put to death. This was done presumably to show others the terrible results of permitting one's thinking processes to lead him to unconventional conclusions. If a daring honest mind led one to say that the earth is round, not flat, this thinker's life had to be taken, lest his heresy should be accepted by others. If a patriot questioned the divine rights of the king, this patriot was thought to be dangerous to the common good. If one claimed the right and accepted the responsibility of thinking through and acting according to his own conclusions regarding spiritual problems, his life was endangered because his thinking might undo the sys- 6 SCIENCE REMAKING THE WORLD terns then in vogue. Even in a country to which our ancestors came in order to think freely, they themselves soon began to shackle, and occasionally destroy, those whose alleged freedom in thinking led to conclusions unacceptable to those in authority. In the present age of science and renewed belief in the power of truth, we see the old and inevitable strife between those who do and those who do not believe in the progressive nature of truth. Attempted legislation against truth merely increases the caution and obligation of inquiring minds, thus helps to refine the inquiry and make the results more secure. Certainly an attack upon a progressive thinker cannot kill progressive thought, but rather by antithesis creates one more spiritual monument in the name of truth seeking. Legislation against truthful, progressive thinking helps to advertise the issues in- volved, and to cause plastic minds to desire to know.1 Even if legislative walls could be erected, progressive truth would leak through, filter beneath, fly above, or, radium-like, would radiate by processes too elusive, too intangible, and too fundamental to be denied its logical advance. Did the persecution of Columbus keep the earth from being round, even though many of the ideas of Columbus's times have since been found to be faulty? Did the persecution of Harvey stop the complete cir- culation of human blood, even though later investiga- tions have corrected many of Harvey 's ideas? Could legislation stop biological development even though thousands of research workers are earnestly endeavour- ing to ascertain unknown truths about the processes involved ? MODERN SCIENCE 7 During the unprecedented scientific development of the past half century, there have frequently arisen cer- tain tendencies on the part of men of science which have caused many non-scientific persons to misunderstand the real nature of scientific truth. A scientific discov- ery is usually much involved in scientific terminology and is complicated by its intellectual associations with a field of special facts and theories. The public usually does not understand the terminology or the related facts and theories as does the scientific worker. Hence the public cannot fully comprehend the discovery or new line of thought. It is extremely difficult for the worker to explain, since his field and even his vocabu- lary are not sufficiently sensed to provide a common basis of understanding. So the worker in science too often belittles the "common man's" ability to under- stand and too often makes no effort to inform him. He does, however, more or less inconsistently expect the "common man" to accept his conclusions in so far as these scientific conclusions touch the fields in which this "common man" operates. The man who knows sometimes becomes intolerant toward the man who does not know, quite as the uninformed man becomes intolerant of the man who knows. Most men, most of the time at least, desire to do what is right, and will oppose or support an idea because their conclusions, or their prejudices which they think are their conclusions, seem right to them. The intolerance of scientific men toward a public which is more or less uninformed about science may easily become quite as objectionable in- tellectually, and perhaps as dangerous socially, as the 8 SCIENCE REMAKING THE WORLD intolerance of a group which is uninformed regarding scientific matters. Further, there is no monopoly of uninformedness. Those who do not know science often do know much of human nature or practical affairs, or of government, or of literature, art, and social relations; and some of these are equally essential in accomplishing the things which are really worth while. It usually helps to get the point of view of the other man, and also increases the light of vision and reduces the heat of friction. One of the heaviest obligations on modern science requires that it shall organize and present many of its results so that these results may be seen and understood by intelligent but non-scientific persons. People will eventually follow the truth, but they cannot follow it unless they can amidst their confusion see its light at least often enough and clearly enough to enable then? to keep the general direction in which truth is moving. In our day they cannot be expected to follow truth too constantly merely by the admonitions of someone whose evidences are known to him but unknown to them. In the rapid development of science another serious social need has arisen among the science men them- selves. The separate sectors or divisions of science have been so compelling in their interest, so gigantic in their possibilities, and so exacting upon the time and energy of specialists, that many specialists have lost perspec- tive of the whole field of science, not to speak of the other necessary human interests mentioned above. MODERN SCIENCE 9 The specialist, however, like other people, guides his life by the stars which he sees, and his conclusions about affairs and people outside of his field are sometimes seriously and harmfully limited. One can and must, if he is a productive student, dig deep into a special sub- ject. But deep wells, while suggestive of depth and height of vision, are not suggestive of broad and comprehensive views. The figure would better be changed to that of a "skyscraper mind," which rises to great heights and consequently may have broad and dependable views, since it stands upon foundations which are secure and since its structural materials are those which will endure under the seasonal and human exigencies of its working environment. One of the greatest functions of our organizations of science men is the bringing together of scientists from various sectors of science and compelling them to learn enough of the elements, at least, of the other fields, to gain some understanding of the purposes, ambitions, and accomplishments of other science men. It would not be bad for science, nor for the public, if special- ists were required to teach other specialists enough to enable all to take a reasonably elementary exami- nation upon the special fields of one another. There is another supremely important function to be served by means of a better public understanding of modern science and its uses. Science knowledge, scien- tific processes and appliances, have reached the stage where ignorance means danger, sometimes destruction. Far more people are killed at street crossings than be- fore the gas motor became common property. The air- io SCIENCE REMAKING THE WORLD plane which "won the war" has exacted the life of many of those who persisted in flying. Gasolene, which also "won the war," is just coming under reasonably safe control. To live in a scientific age, an age of rapidly accumulating knowledge, imposes heavy obligations upon education and upon the resultant social and in- dustrial controls. In the presence of modern science those who do not know cannot long survive, else they must seek the primitive places of the earth where the more elemental practices may persist for a time. Even in these primitive places, science will soon catch up and there will again recur the old biological requirement to learn, to move, or to cease to exist. But the hardest question is yet to come. Has the common appreciation of moral obligations developed to a point where it is socially safe for all science knowl- edge to become common property? Can the common moral sense be trusted? Does knowledge of those* chemicals which will readily destroy human life ever result in an easier suicide or in the more ready destruc- tion of one's human enemies ? Poison gases and other war inventions are so terrible that it is not even safe to allow all citizens to know what a few inquisitive and trusted scientific men have discovered. If a bio- chemico-physicist were to discover just how to change electrical potentials over an area twenty miles square, so that the electrons of human protoplasm would in- stantly break down, it would not as yet be morally safe for the different nations to have possession of this secret. Since science deals with progressive truth, it should not omit its obligation toward better common MODERN SCIENCE n knowledge of useful scientific truth. It dare not omit its due share of the obligation to have modern society develop in moral ideals and controls so that constructive and not destructive use of science shall result. It is surely a heavy burden that is imposed upon modern education. Exact knowledge and faithful in- terpretations of science in themselves provide large obligations. But the still larger one — without which modern science is dangerous — asks that intellectual and moral ideals and controls shall develop in harmony with growth in possession of scientific knowledge. GASOLENE AS A WORLD POWER BY EDWIN E. SLOSSON, PH.D. Director of Science Service, Washington THE work of the world is done by sun power. Whether it be done by the muscular labour of horses or human beings, by the whirling of wind- mills or water wheels, by the burning of wood, coal, or oil, or by the swift and silent electric current, the energy comes directly or indirectly from the solar reservoir. "Give us this day our daily bread" is the same as saying "Give us this day our daily sunshine." But the sun does not shine every day and it cannot shine on all sides of the earth at once and it favours different zones at different times of the year. So man in order to avoid the darkness of night and the cold of winter invented a way of using the sunshine of the past for present needs. According to the Greeks fire was a gift of that foresighted Titan Prometheus who stole fire from heaven and brought it down to man in a hollow reed. For this crime he was chained to the Caucasus and from his torn liver flowed a stream of black petroleum. The Greek mythologists differ as to whether Prometheus was ever released from his chains or not, and we cannot count Shelley as an authority, but the streams of petroleum have continued to flow in the Caucasus to this day. The Zoroastrians came to wor- 12 GASOLENE 13 ship the Fountain of Everlasting Fire, rightly regarding it as somehow a gift from the sun, though how they could not tell, any more than can the modern geologists just how the energy of the solar rays came to be embodied in the blazing oil. Marco Polo, who passed through Baku on his way to Far Cathay, says that a hundred ships might be filled at a time from the lake of oil, and he notes, quite correctly, that it is not good to eat but good to burn and to cure the sore backs of camels. To-day this same Caucasian oil, which was to the Persians the object of adoration and to the Greeks the subject of a grotesque story, is to the modern world a source of power and the desire of all nations. It is the only liquid asset of the Bolsheviki and their efforts to bargain it off to the highest bidder broke up the Genoa Conference and are holding up The Hague. From 1898 to 1901 a ten-mile square of the Baku district supplied nearly half the world's output of oil and it is still the greatest source of the Old World. FIRST USES OF AMERICAN OIL. — But the United States has been favoured above all other nations in the endowment of oil, and it was here that it first became an important factor in civilization. It was from the earliest time used in Pennsylvania, as Marco Polo saw it used five hundred years before in the Caucasus, to cure the sore backs of beasts of burden. The Indians spread their blankets on the creeks that carried a film of oil and wrung them out. The product was sold to the Whites as "Seneca Oil" for man and beast at $2 a gallon. A little more than a century ago a well was being drilled for brine in Kentucky when there burst 14 SCIENCE REMAKING THE WORLD out instead of salt water a stream of black oil that literally set the river on fire. The Kentuckians as- cribed it to a different supernatural source from the Zoroastrians and called it "The Devil's Tar." Now- adays values are reversed and the driller who strikes brine instead of oil is disappointed. In 1859 Drake of Titusville, Pennsylvania, put down a well and thereafter sold Rock Oil at the rate of thirty barrels a day. The value of the new fuel was now be- ginning to be perceived, and after the war the great oil boom set in and millions were gained and lost on paper while petroleum and its products found their varied uses. The great fortunes that are peculiar to our time had their origin in petroleum and it would be impossible to overestimate their influence in all fields of modern life. Why petroleum is an unprecedented wealth producer and how it can be so readily monopolized by individuals or governments can be easily seen by reference to its geology and chemistry. In the first place petroleum comes in pockets and is therefore readily pocketable. It forms pools under pressure, pushed up from below by water and held down from above by a dome of impervious rock. The first man who drills through the rock gets the oil, not only the oil under his own claim but much of what seeps in from his neighbours' claims. Hence the race to get down the first well in a new field. But great haste means great waste. It is estimated that half the oil is lost through lack of system in drilling. Much of it runs off or is burned up before the well is brought under control. More of it is left in the ground through GASOLENE 15 the competitive drilling. At the other end of the pro- cess, the consumption, at least half of the product is wasted, either through burning the oil to make steam when it might be used in internal combustion engines, or by the careless use of the gasolene in automobiles. On the other hand the intermediate part of the process, the refining and transporting, being under unified management and chemical control is carried on with comparative efficiency and economy. Yet we hear little complaint over the irreparable loss of some three fourths of the world's supply in the drilling and the using while there is furious and incessant denunciation of those who carry on the distribution and distillation because they have made so much money out of it. We do not seem to care how much wealth is wasted but we care dreadfully if somebody gets more than we do. Mineral oil therefore lends itself naturally to monop- oly because it is found in but few places in the world and there concentrated in small space; it is also irre- placeable and indispensable. But why has petroleum such a close connection with wealth ? Here the chemist can give the answer. Wealth is produced by the ex- penditure of energy, human, animal, or inanimate. The unprecedented accumulation of wealth within the last hundred and fifty years is due to the utilization of external inanimate energy, chiefly the heat of combus- tion of fossil fuel in the steam and gasolene engine. In America the greatest use has been made of such sources and therefore this country is the richest in the world. If measured in the ancient way in terms of man-power we would each of us on the average have a train of i6 SCIENCE REMAKING THE WORLD twenty able-bodied slaves waiting on us day and night. This increment of energy, that has given to all of us comfort and conveniences beyond the power of petentates in former times, comes mostly from two simple and similar chemical reactions, the union of hydrogen and of carbon with oxygen, or in common language, burning. The first reaction, the uniting of hydrogen with the oxygen to form water gives more heat than any other combination of elements. Hydro- gen would, therefore, be the best possible fuel but for two reasons. In the first place it is too expensive. It is not found free in nature, except in natural gas, and this is rare and running out. To get the hydrogen out of water would require as much expenditure of energy as we should get out of it by burning it back again to water. Secondly, hydrogen is a gas and therefore not convenient to carry around. It would not be conveni- ent to have a big gas bag hitched to your car like a cap- tive balloon. It is true hydrogen can be liquefied but it does not stay so and it is then exceedingly cold. Carbon is tolerably abundant in many countries in the form of coal. But carbon has less than one fourth the heating power per pound that hydrogen has. Carbon, being a solid, is handier to use than a gas like hydrogen, but not so handy as a liquid would be. A solid has to be shovelled. A liquid will flow. Coal has to be mined and hoisted up from the ground. Petroleum is so anxious to get out that it will blow off the rigging when its rock prison is tapped. What, then, would be the ideal fuel if we could have GASOLENE 17 just what we wanted? It would be composed only of hydrogen and carbon. It should give on complete combustion only water and carbonic dioxide, innocuous final products, already in the air. It should contain no ash; leave no solid residue to foul the cylinder. It should contain just as much hydrogen and as little car- bon as possible. It should be a liquid at ordinary tem- peratures but be easily converted to a gas for combus- tion. It must not rot on keeping or freeze on cooling. It should not contain water because that reduces the heating power. Preferably it should look nice and clear like water and not stain things. It must not have a disgusting odour like carbon disulfide, though we will not insist upon absolute odourlessness or a pleasant perfume. Now all these requirements are found in gasolene and in that only. The compounds of carbon and hydrogen are constructed like a chain. Each link is composed of one carbon atom connected with two hydrogen atoms. The first of the series and the simplest possible is me- thane, CHU, but that is a gas. So is the next, but when we get along to the fifth and sixth members of the methane series we get to liquids of the gasolene group. JUST WHAT Is GASOLENE ? — Gasolene is not a single and uniform substance. You who use it know that it varies in quality, especially in volatility. It is simply the lightest part of petroleum, the part that comes over at the lowest temperature when the distillation of petroleum begins. Next comes kerosene, and then the heavy lubricating oils, and later vaseline and paraffin, le asphalt is left behind in the still. Formerly, when 18 SCIENCE REMAKING THE WORLD there was no demand for gasolene, as much of it was run into the next fraction, the kerosene, as it would stand without blowing up in the lamps. Each state had to have an oil inspector whose duty it was to see that no kerosene was sold that had an ignition point below the safety point of the lamps. There is now no difficulty on that score because the temptation is all the other way, to run the heavier kerosene fractions into the gasolene until it becomes too heavy to burn and the motor knocks. In the early days the gasolene, being in- jurious to the illuminating oil and not being much wanted anywhere, was allowed to run from the re- fineries into the streams, where it sometimes took fire. When the introduction of the automobile created a demand for gasolene the refiners awoke to the fact that they had been wasting one of the most valuable parts of the petroleum. Then they began to save and sell their lighter distillates which under ordinary conditions amounted to about 1 1 per cent, of the crude oil. But with the multiplication of motors this did not suffice. It became necessary to break up the heavy oils into light oils, which meant breaking up the big molecules into little molecules. Nobody knows ex- actly how petroleum was formed in the first place, nor even what it was made out of. But presumably it was made from masses of vegetable matter subjected to heat and pressure. If, then, we could reproduce those con- ditions we could shatter this sorry scheme of things and remould it nearer to the heart's desire. This was accomplished by W. W. Burton, president of the Standard Oil Company of Indiana, who worked GASOLENE 19 out a scheme of distillation under pressure which cracked up the heavy oils into lighter fractions. To-day the Standard Oil Company of Indiana has 800 pressure stills which can produce 2,000,000 gallons of gasolene a day. This makes possible the running of 2,000,000 motor cars. In recognition of this achievement the American Chemical Society bestowed upon Mr. Burton the medal that bears the name of Perkin, the discoverer of the first coal-tar dye. The profits of this process are so great that stock in the Standard of Indiana bought for #100 in 1911 would be worth $37,200 ten years later. Crude oil is now made to give on the average 28.5 per cent, of gasolene by cracking and this amounts to 54.4 per cent, of the value of its products. Another new source of motor fuel is the saving of the gasolene vapours that are contained in natural gas. These used to be lost but are now condensed by cooling and provide about 8 per cent, of our present supply. What the invention of the steam engine did for the world we can read about in any modern history. What the invention of the gasolene engine has done we can see for ourselves if we only look about us. The signing of the Declaration of Independence in 1776, which we yearly celebrate by going on a picnic, was a much less important event in the history of the world, even in our own history, then the contemporary discovery of the possibilities of steam power. Watt has had more influence over the current of human affairs than Wash- ington. The Age of Steam lasted a hundred years. In 1876, when we were celebrating our Centennial at Philadel- 20 SCIENCE REMAKING THE WORLD phia, the rival and superior of the steam engine was born. Doctor Otto of Cologne, Germany, in that year made the first practicable engine run by the explosion of a mixture of gas and air instead of by the expansive force of steam. The steam engine was not thereby put out of business. It will continue in the service of man- kind so long as the coal holds out and perhaps longer. But the internal-combustion engine is more powerful and compact, simpler and more economical, and it has already within the observation of all of us gone farther and come into our lives more intimately than the steam engine ever did. The agile auto climbs mountain trails where the railroad cannot go, and reaches com- munities that have never been awakened by the whistle of a locomotive. It has made engineers out of our boys and girls. No schools could teach mechanics as widely and practically as the auto has. Gasolene has given to man the wings he has always longed for but which he had despaired of getting until he got to heaven. It hag enabled men to go down to the sea in ships on their more or less lawful occasions. It has multiplied the magnitude of man by giving him the power to contract all four of the dimensions within which his activities are confined, the three dimensions of space and the fourth dimension of time. What is there about the gas engine that gives it this manifold power and adaptability? Wherein does it differ from the old steam engine? It is not merely in using a different kind of fuel, as some seem still to sup- pose. It is a different kind of motive power. In their fundamental principles, however, the two are alike. GASOLENE 21 What, to begin with, does man want of an engine? He wants it usually to turn a wheel. And right here man shows his superiority to all other animate beings, for none of them makes use of a wheel. Man has no wheels in his body, whatever he may have in his head. If he wants, say, to turn a grindstone, he must do it by a to- and-fro motion of his arm. But in the course of many thousand years man got tired of this and then it oc- curred to him to shift the work from his muscles to the molecules. Man is naturally a shifter; therein lies the secret of his progress. Where could man find a multi- tude of molecules which would be so manageable that he could make them work for him for nothing? He found them where Lenin and Trotzky found their docile Bolsheviki, in a state of anarchy. In any gas the mole- cules have lost all sense of solidarity and reached a state of complete freedom and independence such as man fortunately has never been able to attain. It is self- determination carried to the limit, for in any gas each molecule is at liberty to do what it likes without regard to what any other molecule may do. Every molecule therefore goes straight ahead in its own way until it runs up against some other molecule or a wall; then it gives the obstacle a kick and goes off in some other direction. The kick is light since the molecule is small, but if all the kicks could be combined and turned in one direction they would amount to something and could be used for something. Force directed by intelligence produces power, and power directed by intelligence produces prog- ress. As soon as man acquired the intelligence he util- ized the aimless force of the molecules knocking against *2 SCIENCE REMAKING THE WORLD the prison walls of the containing vessel as a motive power for his own purposes. This was accomplished by the simple expedient of making one of the partitions movable. If a crowd of molecules are imprisoned in a steel cylinder they bump incessantly against all the sides equally as though trying to get out. If, now, one of the ends is a piston head, slipping easily in the cylinder, this gets shoved out by the constant pounding until finally the exhausted molecules make their escape into the open air. WHAT HAPPENS IN AN ENGINE? — If the molecules are crowded into a prison half the size by shoving in the piston partition they naturally knock against it twice as often. This observation is so obvious that you will probably not appreciate it properly until you know that it is called "Boyle's Law." Then again if you shove in the piston head suddenly and crowd the molecules into smaller space they naturally get hot about it and do more knocking than ever. The hotter they get the harder they pound against the prison walls. This also is so easy to see that you will not get credit for it, even from yourself, unless you dignify it by calling it the "Law of Charles" and expressit in such words as: "The pressure of a gas at constant volume is proportional to the absolute temperature." Having now in mind the two laws that all anarchic molecules obey we can see how we can get the most work out of a given number of them. Obviously this will be, first, to confine them in the smallest space and force them to fight their way out to the largest possible space. Secondly, to get them as hot as possible and let them GASOLENE 25 cool off as completely by exhaustion. Or in other words, the efficiency of an engine depends upon getting the longest possible range of pressure and temperature be- tween the beginning and the end. The automobile is run by two horses, heat and cold. The higher the heat and the lower the cold, the greater the power. We can use any gas we like for our engine, for all gases behave about the same. Naturally steam was the first gas used in the cylinder. But steam has to be made separately in a boiler and then conducted into the cylinder. And a boiler is a bulky thing and oc- casionally blows up. To heat the boiler there must be a furnace and to the furnace there must be attached a tall chimney to create a draft. A pile of coal must be at hand and a stoker to shovel it in. If the engine is large and complicated there must be an engineer, duly licensed and a member of the union. There is inevit- ably tremendous waste of potential energy, for the steam has at best a small fall of temperature while it is doing its work in the cylinder. It is not nearly so hot as the furnace gases which are lost up the chimney. If in some way we could combine the furnace and the boiler and burn the fuel in the cylinder itself, right where we want to do the work, we could take ad- vantage of the high temperature to get high pressure and simplify the apparatus. This is just what is done in the gasolene engine. The cylinder is made the fur- nace. Fill it up, by a jerk of the piston rod, with air mingled with a little vaporized gasolene, set it afire with an electric spark. The carbon and the hydrogen of the gasolene unite with the oxygen of the air, forming car- 24 SCIENCE REMAKING THE WORLD bon dioxide and steam. The heat of combustion raises both these gases to a high temperature and therefore to a high pressure and the piston is pushed out and turns the wheel, and there we are. We have done away with the big boiler, the tall smokestack, the fiery furnace, the pile of coal, the skilled engineer and the fireman. We can have a range of temperature two or three times as great in the gas engine as in the steam engine and so get two or three times the efficiency. That is, more than twice the percentage of the total energy in the fuel may be got out in the form of usable energy by the gasolene engine besides its advantages in compactness, clean- liness and convenience. No wonder then that it has transformed the conditions of modern life. The steam engine and the gas engine passed from peaceful competition to armed conflict in 1914 and the newer motive power won the war. Senator Berenger of France said that the Germans expected to win be- cause they had the advantage over France in coal. But the Allies won with the aid of oil. "It was a vic- tory of the automobile over the railroad," he says. This is confirmed by Lord Curzon, who said: "The Allied cause was floated to victory on a wave of oil." We first realized the possibilities of the new military machine in September, 1914, when we read that the taxicabs and omnibuses of Paris had been mobilized to carry Gallieni's army out from the capital to attack Von Kluck's invading forces in the rear and aid in driving them back from the Marne. From that time on both parties relied more and more upon the mobility of the motor. Germany, having no GASOLENE 25 oil fields of her own, was forced to seek a supply in Poland and Roumania and so turned her attention from France and Belgium to the eastern front. Thanks to the supply of American petroleum the steady line of camions was kept going into Verdun and so the enemy did not pass the cornerstone of the French frontier. But in December, 1917, the French petroleum trust notified their government that their stock would be exhausted by the following March and that they could not supply the army in time to meet the German spring attack. The monthly consumption of gasolene was 30,000 tons and the stock had fallen to 28,000 and soon would be reduced to nothing. Then Premier Clemenceau sent an urgent cablegram to President Wilson, personally requesting him to use his authority to bring the 100,000 tons of tankers from the Pacific to the Atlantic where they might replace those that the Germans had sunk. M. Clemenceau closed his appeal with the words: "If the Allies do not want to lose the war it is necessary that fighting France, in the hour of the supreme German shock, should possess the gasolene which is as necessary as blood in to-morrow's battle/' President Wilson complied, and the Petroleum War Board supplied the ships used to bring the motor fuel to France. Thanks to this prompt action Foch was able to send an auto army to fill the gaps next spring when the British gave way before the German drive toward Amiens. It is not necessary for me to speak of the gasolene- driven submarines, for what they did and what they nearly did is all too fresh in the memory of us all. But 26 SCIENCE REMAKING THE WORLD we should recall that the swift motor boats that guarded the coasts were also run by gasolene. Nor can I stop to discuss what the new art of aviation meant in the war. Leonardo da Vinci designed a fly- ing machine but it had to wait for five hundred years for a motor light and strong enough to carry it through the air. But aviation as yet plays little part in our everyday lives so let us turn to the automobile, whose influence we can observe for and on ourselves. In 1896 there were only four gasolene cars in the United States. To-day there are 10,000,000. Of these four pioneer automobiles, one was built by Elwood Haynes of Kokomo, Indiana, one by Henry Ford of Detroit, one by C. E. Duryea of Pennsylvania, and one by Benz of Germany. These early cars were called "horseless carriages" and that is what they looked like, as though the horses had been unhitched and the buggy left to run down hill alone. Many inventions come in this negative way; wireless telephones, fireless cookers, smokeless powder and the like. Something left out makes something new. This seems to be also nature's way, for biologists tell us that valuable mutations in plants and animals often arise from the omission of some single chromosome that has accidentally got lost in the shuffle. Gradually, however, the motor car ceased to look like a mere mutilated vehicle and assumed a form and sym- metry of its own. The horse, who had most reason to view with alarm the advent of his fiery rival, soon became oblivious to it. The machine, at first re- fused admittance to the highways, came in the course, GASOLENE 27 of time to dominate them. Up to 1896 automobiles were prohibited from running on the English public roads faster than four miles an hour and even then the law required that a man should walk in front waving a red flag. This had a tendency to hamper the develop- ment of the automobile in England. Just so, a hun- dred years before, Parliament had refused to allow a thirty-mile railroad to be built on which Stephenson's engine could run from Manchester to the sea. Thomas Creevy, who was on the committee that killed the bill in 1825, writes in his diary: Well — this devil of a railway is strangled at last . . . this infernal nuisance — the loco-motive Monster, carrying eighty tons of goods, and navigated by a tail of smoke and sulphur, coming through every man's grounds between Manchester and Liverpool. Now the situation is reversed and the auto has the upper hand. It is already proposed to prohibit the use of horses in New York City within a few years. Cer- tainly anybody with a heart, who has seen the city in a snowstorm when the poor horses slip and fall on the icy pavement and have to be whipped to force them through the drifts with a light load, will rejoice when they have been displaced by the tireless and unfeeling truck. Suppose there had never been horses and livery stables in the city. What would happen to the man who tried to introduce them ? The police, the health depart- ment, the humane societies and the street cleaners would unite to banish horses from the city, but they would have to work quickly to get ahead of the mob. In any innovation the majority of men see the disadvantages 28 SCIENCE REMAKING THE WORLD before they see the advantages, while in regard to the things to which they are accustomed they ignore the faults and value the virtues. THE GREATEST INVENTIONS. — Macaulay says: "Of all inventions, the alphabet and printing press alone excepted, those that have shortened distance have done the most for humanity." Then gasolene, which has given man a higher speed than he ever attained before, must rank among the most beneficial of human in- ventions. It has enabled man to travel in one hour 180 miles in an automobile and 220 miles in an airplane, and to rise to a height of 41,000 feet in the air, 2,000 feet higher than Mount Everest, which British explorers have been trying vainly to ascend. Such records, though they may gratify man's am- bition, do not benefit his life. The real advantages of rapid transit are that it gives him greater power to overcome the limitations of nature and lengthens his life as measured by his activities. For practical pur- poses distances are measured by the watch, not by the map. "Twenty minutes from Times Square" means something definite, if true. "Ten miles from Times Square" means nothing, for it varies widely according to direction. The dimensions of cities, counties, states, and na- tions depend upon the rapidity of communication. The faster our vehicles the larger may be our political divisions. The smallest territorial unit of our country used to be the school district, which was measured by the length of the legs of the littlest children. This vir- tually ceases to have significance when the school 'bus GASOLENE 29 can collect the children from a county and bring them to a central school. The radius of a metropolitan area is determined by the average time taken out of the day in coming in to shop or office and going home again. The extent of territory reached by a newspaper or a store depends on the delay in delivery. Cutting the time in half means multiplying the tributary territory by four, for the area increases as the square of the radius. One may almost say that the area increases as the cube since we have by skyscrapers invaded the third dimension and are building cubical habitations. Any new scheme of speedier intercommunication tends to expand the boundaries of political divisions. But it does more than that. It weakens the boundaries themselves. Statesmen may cut up continents into countries but science knows no nationality. Ideas will somehow leak through from one language to another. Print and pictures will penetrate anywhere. The map may be coloured like a crazy-quilt, but nobody can put up partitions in the ether. The frontier may be lined with soldiers, the radio will overreach them. The three- mile limit of the high seas has ceased to have meaning. The self-propelled projectile, the auto-airplane, carrying death in its bombs, has no limit to its range. No wall, trench, or barbed-wire fence can shut out the molecules of poison gas. The airplane soars over custom houses. The submarine dives under blockades. The automo- bile runs across tariff walls. Science erases the artificial barriers that the politician erects. As the world comes under the sway of science political divisions will be impossible to maintain. 30 SCIENCE REMAKING THE WORLD Commerce, the child of science, is doing more to pro- mote the unification of the world than all the politicians. Politics is the art of managing men. It was therefore of supreme importance in the days when war and work were done by men. But as war and work come to be done by machinery the importance of the politician diminishes as the importance of the engineer increases. The financial side of the automobile business is in- teresting but puzzling. The best estimate of the an- nual expenditure on motor cars in this country for 1921 makes the total out to be $7,783,000,000, distributed as follows: New Cars #1,448,000,000 Depreciation 1,800,000,000 Interest 295,000,000 Tires 450,000,000 Gasolene 823,000,000 Oil 175,000,000 Garage 552,000,000 Repairs and Supplies 1,000,000,000 Insurance 185,000,000 Taxes 275,000,000 Drivers' Salaries 600,000,000 Road Maintenance 180,000,000 $7,783,000,000 That is to say, we are spending approximately eight billions of dollars a year on something that did not exist twenty-five years ago. Where does the money come from? I am not com- plaining of extravagance. I am not saying that it is a cent too much. But it would be interesting to find out, if we could, from what sources this immense amount of GASOLENE 3r money has been derived. Here is a new channel of expenditure into which an enormous flood of funds has been suddenly turned. From what other channels has it been diverted ? If we say it comes from the recent general increment of wealth or the fictitious increment due to inflation, then we can put the question in another way: For what would this eight billions of dollars be spent if there were no motor cars? I do not know that the question can be answered statistically but perhaps you get an answer from indi- vidual observation or experience. When a man buys a car and spends say a thousand dollars a year on it in interest, depreciation and supplies, what does he economize on? Does he take it out of his savings or what he otherwise would have laid up for a rainy day? But savings and investments have also increased during this period. Does a family after it owns an auto spend less on clothing or food or theatres or books or summer resorts or golf? Or does it spend more? Is there a saving on shoe leather by using rubber tires? But more is spent on shoes and clothing than there used to be. So of almost everything else. The only field in which a definite falling off can be discerned and ascribed to the introduction of the auto is in carriages, city sta- bles and the like, but this is little compared with what is spent on motor cars and motoring. The building of railroad mileage has been virtually at a standstill for a number of years, though the popu- lation and business activity of the country have been increasing. It may be said, then, that a large part of the money spent for motor transportation would other- 32 SCIENCE REMAKING THE WORLD wise have been put into spur-line railroads, electric railways or else, which is more probable, there would have been much less in the way of transportation facili- ties available and consequently less wealth created. The creation of rail lines covering the network of highways over which motor cars travel, would probably be pro- hibitive in cost. A saving in the wages of farm workers has been an- other source of income for automobile investment. There has been a drift of farm population to the cities without as yet a noticeable diminution of the volume of farm products. The decrease in labour has been taken care of by farm machinery, including motor transportation, which has tremendously increased the amount of time at the individual farmer's disposal as compared with the horse-and-buggy days. Another source of possible saving is in city rents by removal to the suburbs and country, which would leave the difference in rent available for motor transportation. But city rents have not perceptibly fallen and there is also the extension of city deliveries into the vicinity to balance this economy. Besides the question of money expenditure there is the question of time expenditure, equally important and equally unanswerable. Leaving out of considera- tion the commercial use of motor cars there is an enor- mous amount of time spent in pleasure riding, in taking care of the machine and talking about it and in sitting around waiting for a new tire to be put on. How was this time spent formerly or how would it be spent now if there were no automobiles ? Here we are not both- GASOLENE 33 cred by a change in the standard of measurement. The length of the day is one of the few things that the war has not altered. Has there been a decline in sleeping, reading, seeing motion pictures, playing cards, going to church or what? Unfortunately we have no census figures on how we spend our spare time although many less important queries are asked us by the Census Bureau. I used to ask such questions as these of my students in the School of Journalism at Columbia and while the answers were not always valuable I am sure the ques- tions were. The important thing is to get a realization of the innumerable and various ways in which any such invention affects all our lives. The same question would often bring opposite answers but I was not under the painful necessity of marking either one of them wrong. Take, for instance, this question of the effect of the automobile on church attendance. Some of my students would report that the congregations had fallen off, for the people went riding on sunny days while on rainy days they could not be expected to go to church. But students from other sections would say that church attendance had increased because the people could come from many miles around and it took less time. There would seem to be something in this because the churches have grown in membership during the auto- mobile era and why should people join a church if they do not go to its meetings ? Another question bringing different answers was the effect of the automobile on the spirit of democracy. Students from New York City were apt to say that it 34 SCIENCE REMAKING THE WORLD had intensified the tension between social classes be« cause the poor pedestrian resented having to turn out of the road at the honk of the plutocrat and receive a whiff of scorched gasolene in return. On the other hand students from the West reported that the automobile was an agency for democracy for it had wiped out the distinction between classes. Formerly when the few had buggies and the rest had to ride to town in lumber wagons the former set looked down on the other but now that all had automobiles they were substantially on a level. This must be the case in such states as Cali- fornia, Iowa, South Dakota and Nebraska, which have one motor vehicle for each five and a fraction persons, that is, one for every family. Once I asked my class to "specify the influence of the automobile in political, commercial, social, and martial affairs." I got unexpected answers, for some students seemed to have difficulty in reading my writing on the blackboard and mistook the "martial" for "marital." But I was glad of the misunderstanding for the answers were interesting. Some said that automobiles pro- moted marriages by providing courting parlours but others said they dissolved marriages for similar reasons. Here, as usually, the truth lies not in the mean but at the extremes. Two opposites may both be true but if we average them we may get nothing, or a falsehood. Many a fallacy has come into sociology through dealing with an average man who does not exist. It was commonly assumed that the automobile would relieve the congestion of our cities and check what was called their " abnormal growth." The mental GASOLENE 35 conservatism of the masses of mankind leads them to call anything "abnormal" that is merely unprecedented. The expectation that there would be an exodus from the cities if opportunity were offered was based upon the unconscious assumption that people were more anxious to get out of the city than to get in. But it seems on the contrary that the pressure of population is from the rarer to the more densely inhabited districts: the re- verse of the law of gases, for men do not always behave like molecules. Our cities continue to grow and the bigger they are the faster they grow. Autos are more used to bring countrymen into the town than towns- men out to the country. However the balance lies the net result is to bring about a greater mixing of rural and urban population. God made the country. Man made the city. Gasolene made the suburb. CHANGES IN THE COUNTRY. — The roadside inn has been revived. Front rooms of farmhouses, formerly only opened for weddings and funerals, have been turned into tea houses. Apples and berries, sweet corn and melons, are set out on a box by the roadside in charge of a child as salesman and the passing autos take their pick of the produce as though it were a cafeteria. This brings the grower and eater directly together and omits the middle man or men. That the city dweller is led by a love of nature into the country is evidenced by his effort to bring the country back with him by filling his car with other people's flowering trees and bundles of flowers. But all men kill the thing they love. Before the end of the season there are few flowers left within the radius of the afternoon ride and next season there 36 SCIENCE REMAKING THE WORLD may be none, unless some means may be found for add- ing brains to enthusiasm. A sylvan solitude loses its chief attraction when it becomes densely thronged. The motor furniture van has facilitated the fondness of Americans for moving. All the contents of a seven- room flat in New York City may be stowed, without crating, in a van and set up in a house in Washington next day without breakage, loss, or delay. Already the motor truck is a close rival to the railroad car in ton- nage carried. (In 1921, tonnage carried by truck, 1,430,000,000; by railroads, 1,641,000,000). In the number of passengers and the number of miles they were carried the motor cars have gone far beyond the trains. (In 1921, passengers carried in motor cars, 7,000,000; in railroad cars, 1,000,000. Passenger mile- age: motor cars 71,000,000, railroads 37,000,000). The spread of the automobile created a demand for new materials in large quantities, for something that would give a stouter skeleton and a softer tread. Metals like vanadium and molybdenum, names so unfamiliar to the people that they had to be taught in advertisements how to spell and pronounce them before they could ask for them, were needed to give steel a greater elasticity and strength, and these "rare ele- ments" had to be provided by the thousands of tons. During the automobile races of 1905 in Florida a French machine went to smash. There happened to be hang- ing about, a man with an abnormal curiosity, Henry Ford. He picked up a fragment of the wrecked racer, a valve stem, and found it lighter and stronger than anything he could make. He had it analyzed and GASOLENE 37 found that it contained vanadium, a metal that Ameri- can steel makers did not know how to use. Special furnaces had to be made for it since vanadium melts at 3,000 degrees Fahrenheit and the ordinary steel furnace could not run above 2,700 degrees. But vanadium steel is two and a half times as strong for equal weight as common steel and was therefore peculiarly fitted for a car that was to be light and tough, as well as cheap and simple. THE BEGINNINGS OF RUBBER. — The boom in rubber had begun before, in the Bicycle Age, when an Irish horse doctor named Dunlop tied a rubber tube around the rim of his boy's velocipede, and blew it full of air. Brazilian forests could not supply the caoutchouc needed for pneumatic tires and electrical apparatus, so attention was turned to the Congo, where a reporter for the New York Herald named Stanley had established a Free State under the patronage of the leading Euro- pean nations and the United States. The protecting powers, anxious to make the natives safe and happy and fearing that they might be exploited if put under one of the greater powers, picked out a benevolent looking old king with a long white beard and gave him a man- date for the Congo. King Leopold of Belgium was a high liver and a free spender in the promotion of the fine arts, especially drama and dancing, and was not content with the 300 to 800 per cent, income on the capi- tal invested. So the Belgian officials in the Congo, to get their tale of rubber, drove the negroes deeper into the jungle. Men were murdered, women were flogged, children had their hands cut off. Finally the Congo 38 SCIENCE REMAKING THE WORLD atrocities aroused the moral sense of the world and the Free State was rescued from the hands of Leopold. In 1910 the price of Para rubber had risen to $2.00 or $3.00 a pound and the forests were being depleted of the trees. Then science came to the rescue and showed how an unlimited supply of the precious gum could be obtained without robbing the natives or ruining the trees. This was by cultivating the rubber tree. The fore- sighted British and Dutch set out rubber plantations and produced a better product than thewild rubber for 25 cents a pound or less. The United States consumes some 75 per cent, of the world's rubber but it is all foreign grown. Akron, Ohio, alone manufactures over a third of the world's rubber. We found what it meant to have neglected to cultivate our own garden when the war broke out and threatened to ruin the third largest of our industries by taking off our tires. We had to pay whatever the British and the Dutch cared to charge us, and they reaped a rich harvest from their providence, but in 1920, when the automobile business took a sud- den slump, the price of rubber fell from 55 cents a pound to 13. Three per cent, of the rubber plantations of the world are now owned by American companies but none of them have been placed in our own tropical possessions. Dutch and British dependencies are evidently considered more dependable than ours. So we see that development of a new motive power affects international relations everywhere. The same thing may bring ruin to the Congo and prosperity to the Malay Peninsula. Recently the British have put an export tax on their rubber and we are beginning to GASOLENE 39 wake up to the desirability of having a few rubber trees in our own yard. So Congress has consented to ap- propriate $500,000 to see if we cannot grow rubber under the American flag in the Philippines or elsewhere. Hardly had the automobile been born before it began to complain about the roads, especially in America. In Europe the roads were better than ours, thanks to the Romans who, whenever they conquered a country, made a good road through it leading straight to Rome and so solid that it lasts to this day. The French cars that we first imported groaned dreadfully over our rough roads, sometimes indeed balked at travelling in the dirt. So we resolved to mend our ways and have done wonders in a few years. In the period 1910-1921 over two and a half billion dollars were spent in road construction in the United States. The Federal Government has come to the aid of the states and at the end of 1921 there had been completed 12,900 miles of good roads, costing about $221,000,000, of which the Federal Government had contributed 46 per cent. Although the improvement of highways is chiefly due to the demands of the motor car they ease the labour of the surviving horses. The automobiles wear out the roads more than horse-drawn vehicles but on the other hand they contribute heavily to the government rev- enues. New York City alone takes in $6,000,000 a in motor fees — not counting fines. In 1921 the states received in registration and license fees and gas- olene tax more than $132,000,000. Altogether it is esti- mated that motor vehicles paid into the treasuries, state, national and municipal, $341,300,000 in 1921. 40 SCIENCE REMAKING THE WORLD Taking the locomotive off the rail and putting it on the road is in itself a revolution of wide-reaching in- fluence. With a network of good roads covering the country and with vehicles that require no other track, our population has acquired a flexibility of movement that has amazing consequences. The jitney can shift its routes from day to day according to where the people want to go, while the tramcar must stick to its trolley and track regardless of traffic. A touring car can change its mind in a moment's caprice while the rail- road train must follow the time-table. In England the rural districts are getting disturbed by the inva- sions of cockneys in the char-a-banc or motor lorry. The transformation of the farm by motor fuel, strik- ing as it seems, is only beginning. Agriculture has so far been comparatively little affected by the industrial revolution. This is because the revolutionary agent, the steam engine, has not found a place upon the farm as it has in the factory. Farm work is too varied and scattered to be run by a central power plant. Look into one of our big steel plants or machine shops and you will be struck by the scarcity of men. The building seems deserted when it is really most active. Here and there is a man moving about looking after things. Groups of three or four may be standing by a process and occasionally intervening. If you find a bunch of a dozen straining their muscles in lifting or pulling you may be sure that something has gone wrong with the machinery and they are fixing it up. The human muscular labour that has been so largely eliminated from the factory is still the mainstay of GASOLENE 41 the farm. The horse aids man but does not supplant him. The gasolene motor may 'do for the farmer what the steam engine could not. The motor is small, light, portable, cheap and easily managed. The tractor is capable of doing the work of two or three teams of horses although it seems that the farmer must still keep a team or two. For the road haul and running to town the motor vehicle is rapidly displacing the old lumber wagon and buggy. There are about three million motor vehicles used on American farms. Of these 150,000 are trucks. The states having most cars on farms are Iowa, Illinois, and Ohio. The states having most trucks on farms are Pennsylvania, New York, and Iowa. In many places gasolene has knocked the picturesque milkmaid off her three-legged stool. A motor will milk a dozen cows at a time and never complain of the chores, and the mechanical milkmaid is more sanitary. The day of the open pail is passing. We may hope to see the man with the hoe supplanted by the man with the Ford. His brow will not slant so much, for the farmer of the future will have to be a high-brow to manage power machinery. Where will the fuel come from to run all these new machines? The world's oil-tank is running dry and we are not yet in sight of a new supply. The United States, that was the best endowed, has been most ex- travagant. We have wasted the greater part of our oil and have sold to everybody that would buy. Now, like the foolish virgins, we must ask others for oil and are likely to get the same reply. Nobody knows how much petroleum there is left in 42 SCIENCE REMAKING THE WORLD the ground in various parts of the world, but it is evi* dent that it is not enough to go around. According to the estimate of the United States Geo- logical Survey there is still underground in the United States some six billion barrels of oil. This seems like a lot, but we are burning over half a billion a year. Half a billion goes into six billion twelve times which would put the date of the practical exhaustion of American oil fields in 1934 at the present rate. But the rate of consumption is increasing. Between 1910 and 1921 the consumption of crude oil in the United States arose 68 per cent., while the domestic production increased only 56 per cent. Therefore our importations increased 600 per cent, for the same period. Last year we had to im- port more than 125,000,00x3 barrels of petroleum and we will have to import more and more every year hereafter — if we can get it. What can take the place of gasolene for the motor? There are two present possibilities: shale oil and alcohol. Either will be more expensive and less satisfactory, so the transition will bring about a new sociological transformation. I have shown how naturally the distribution and dis- tillation of petroleum led to the concentration of great wealth in the hands of a few individuals. Many of those who "struck it rich" in the early days spent their money about as quickly as they got it on reckless personal extravagance. This had only a temporary effect on society and that altogether bad. But greater wealth has come into the hands of some who have spent it in carefully contrived means for public welfare. GASOLENE 43 Mr. Rockefeller's donations to education and welfare organizations amount to more than half a billion dol- lars. From this source about $10,000,000 a year is dispensed, largely for medical education and public sanitation. Last year two millions were promised to Harvard for a school of health, a million to Columbia, three and one half millions for rebuilding the medical schools of Brussels. A complete modern medical school has been established in Peking and twenty-five other .medical centres in China have been helped. Consider what it means for the four hundred million people of China to have scientific research established there at this critical period in their history. Nineteen coun- tries besides our southern states have been helped in unhooking the hookworm. Campaigns against yellow fever and malaria have been instigated the world over. How much does that mean for the increase of human health and energy? Notice that these donations, large as they are, do not compare with what the communities concerned will themselves spend in the work thus started. Who can estimate the influence of the Univer- sity of Chicago and of the other universities which its founding has effected? Here are profound and far- reaching sociological effects resulting from the almost accidental accumulation of this wealth in the hands of one particular man. Any other man or group of men would have spent it differently, worse or more wisely, as you choose to think. How HAS GASOLENE AFFECTED Us? — I must not close without mention of the psychological effects of the introduction of gasolene, its influence on the mind of 44 SCIENCE REMAKING THE WORLD man. The horseman realizes that he is dealing with an intelligent or a wilful, capricious, and perhaps vicious animal, whose conduct will be affected by his own tem- per. The chauffeur knows that he is handling a ma- chine which cannot be punished or coaxed. Anger has no effect on an auto-engine. To display or even to feel any emotion toward it is simply silly. In Wells's Freu- dian novel, "The Secret Places of the Heart," the man who in a fit of fury smashes up his wife's dainty sedan betrays thereby his subconscious animosity toward the owner. The substitution of machinery for all slave and animal power and even in large part for personal service must in the long run have very profound effects on human character. A professor of psychiatry tells me that he prescribes automobile driving for certain types of nervous patients, especially such as suffer from inability to concentrate their minds on anything outside of themselves or who are deficient in quick decision. The chauffeur who hesitates is lost. The automobile obviously cultivates celerity of decision on the part of the pedestrian as well as of the driver. When the automobile first came into use it was said that it was dividing the population into two classes: the quick and the dead. This has ceased to be a joke. More than twelve thousand persons are killed each year in the United States by automobiles. How many persons do you suppose were killed in Great Bri- tain during the late war by all the shells and bombs from German ships and airplanes and zeppelins? Six hundred forty-two, or about I per cent, of our death rate from motor cars. GASOLENE 45 The acquisition of external energy, as in employment of gasolene, means an augmentation of the individual. The management of a machine gives one a sense of personal power, much like that of the consciousness of controlling other human beings but less harmful in its reflex effect on the possessor of the power. This sense of power is doubtless one of the chief reasons for the fondness for fast driving. The best expression of this feeling that I have found in literature is the following passage in Maurice Maeterlinck's essay on the automo- bile in "The Double Garden": The pace grows faster and faster, the delirious wheels cry aloud in their gladness. And at first the road comes moving towards me, like a bride waving palms, rhythmically keeping time to some joy- ous melody. But soon it grows frantic, springs forward, and throws itself madly upon me, rushing under the car like a furious torrent, whose foam lashes my face; it drowns me beneath its waves, it blinds me with its breath! . . . Now the road drops sheer into the abyss, and the magical carriage rushes ahead of it. The trees, that for so many slow-moving years have serenely dwelt on its borders, shrink back in dread of disaster. They seem to be hasten- ing one to the other to approach their green heads, and in startled groups to debate how to bar the way of the strange apparition. But as this rushes onward, they take panic, and scatter and fly, each one seeking its own habitual place; and as I pass they bend tumultuously forward, and their myriad leaves, quick to the mad joy of the force that is chanting its hymn, murmur in my ears the voluble psalm of Space, acclaiming and greeting the enemy that hitherto has always been conquered but now at last triumphs: Speed. . . . Space and Time, its invisible brother, are perhaps the two great enemies of mankind. Could we conquer these, we should be as the gods. When I told M. Maeterlinck how much I admired it he laughed heartily and said that the inspiration of the rhapsody was one of the primitive five-horse-power 46 SCIENCE REMAKING THE WORLD machines of twenty years ago that got out of breath when it climbed a hill and occasionally broke down on a level. But I do not think he can write any better now that he has a modern racer. The French seem to be quicker than we in perceiving the poetry in modern inventions. Maeterlinck's prose poem on the first automobile may be matched by Ed mond Rostand's sonnet on the first airplane: J'avais sur la montagne un grand jardin secret Mais, ce soir, se levant du fond de la campagne, Le long biplan que Toeil des bergers accompagne Vint a ma solitude infliger un soufflet. Car, doublant mon toit basque ou, presque, il s'eraflait, Le monstre pour lequel il n'est plus de montagne Passa sur mon jardin comme le vent d'Espagne, Et mon sable cut son ombre, et mon lac son reflet! J'aurais du t'en vouloir, 0 beau monstre de toile, Moi qui n'ayant cherche que 1'aigle et que 1'etoile Suis venu sur ce mont, loin du plaisir humain, Pour avoir a moi seul un ciel qui se deploie! Mais j'ai crie d'orgueil et j'ai pleure de joie Lorsque j'ai vu mon ciel devenir un chemin!1 'For the benefit of those who do not read French my wife has put thi poem into English verse: A high and secret garden was my own. This evening, rising from the low champaign, While shepherds stood astare, the long biplane Above my sheltered seat was swiftly blown, And buzzed about my Basque roof with its drone! The linen monster mountains bar in vain, Passed o'er my garden like the wind from Spain; A moment's shadow on my lake was thrown. Fair monster! Should I not have wished you far; I, who to seek the eagle and the star, To claim a space of heaven for my abode, Had climbed the height to human joy denied? I wept with joy and shouted out with pride To see this heaven of mine become a road! GASOLENE 47 GUIDE TO FURTHER READING "Discoveries and Inventions of the Twentieth Century," by Edward Cressy. (Dutton and Company.) Contains chapters on petroleum and gas engines. "Chemical Discovery and Invention in the Twentieth Century," by Sir W. A. Tilden. (Dutton and Company.) 1916. Contains chapters on petroleum and rubber. "America's Power Resources," by C. G. Gilbert and J. E. Pogue. (Century Company.) 1921. Shows the economic significance of coal, oil and water-power. See also the same authors' "Energy Resources of the United States," Bulletin 102, Smithsonian Insti- tution, Washington. "Gasoline and Other Motor Fuels," by Carleton Ellis and Joseph V. Meigs. (Van Nostrand Company.) 1922. Comprehensive volume on the manufacture of gasolene. Reports of the United States Bureau of Mines for statistics of production of petroleum products. Yearbook of the National Automobile Chamber of Commerce (N. Y.)t and current motor magazines for figures on the development of the industry. For the sociological effects of the introduction of the gasolene motor the reader will have to rely upon his own powers of observa- tion and reasoning. THE INFLUENCE OF COAL-TAR ON CIVILIZATION BY EDWIN E. SLOSSON WHAT were the most precious things in the ancient world? What would a king bring to a great king whose favour he sought? What would the great king offer to his god? When a daring trader had reached the Far East after untold hardships by land and sea for many months, what commodities would he pick out to purchase and take back, knowing that he must make his fortune out of what he could carry on a camel's back, or perhaps his own, through the torrid desert, beset by robbers, and over the icy mountains ? You know what he could buy to take back if you know your Bible, or even if you know your Arabian Nights. You could inventory that cargo from such fragments of ancient verse or prose as linger in your memory. You know that when his pack of rare and precious goods was opened it would be found to be filled largely with what are now called coal-tar com- pounds. Not much else, except gold and gems. There would be dyes and drugs, perfumes, and preservatives; whatever amorous youth would choose to enhance the beauty of his lady love, and whatever pious youth would use to embalm the body of his father; whatever 48 COAL-TAR 49 would colour the curtains of the palace of the king or of the temple of the deity; whatever would serve to scent the banquet hall or ascend to heaven as incense from the altar. Now these that were the gifts of kings, the prerogative of royalty, the acme of luxury, all these have, by the bounty of science, been put within the reach of all. To be born to the purple is no longer a distinction. It is the natural heritage of any American babe. King Solomon in all his glory was not arrayed like a lady who has all the aniline dyes at her disposal. The shop girl may rival the Queen of Sheba in her employment of perfume — and she often does. But notice this — that perfumes and similar luxuries are not used so lavishly now when they are cheap as int the days when they were rarities. They are not abused by the many as they were by the privileged few. We may think that nowadays some people put too much scented unguent on their person, but we never see any one with so much of it as was used in the case of Aaron, where it soaked his head, ran down to the tip of his beard and went on to grease his garments to the skirt and doubtless formed a puddle on the floor. If we should see and smell anything like that to-day, there would indeed be reason for outcry against the growing extravagance of the age. All of the comforts and conveniences of our ordinary life were on their introduction denounced by moralists as extravagant and demoralizing luxuries. Juvenal de- clared that Rome was in decadence because the rich used ice and white bread at their banquets. But now- So SCIENCE REMAKING THE WORLD adays to live on white bread and iced water is not re- garded as wicked indulgence. Nobody objects to it ex- cept those who think that brown bread and tepid water are better for the health. This does not prove that Juvenal and such satirists were wrong. On the contrary they were doubtless right, for the aristocrat who ate white bread and drank cold drinks when nobody else in the city could afford them, did feel a selfish satisfaction at his superiority and so it was demoralizing to him. But when the roller mill and the refrigerating machine brought these table delicacies to the level of common life they became quite harmless. The way to make a luxury innocuous is to make enough of it to go around. When it becomes cheap it ceases to be extravagant, and when it becomes common it ceases to be exclusive, and therefore it is no longer a menace to morality. Isaiah was doubtless justified in denouncing the daughters of Zion for their "changeable suits of apparel," but I do not think he would say the same now when a package of dye soap can be bought for ten cents. For the ladies who change the colour of their apparel by the use of such coal-tar products do not> I am sure, feel sinfully set up about it. The coal-tar products form a new factor in our civili- zation. Not long ago, chemists celebrated the fiftieth anniversary of the day when a London schoolboy, wash- ing up his glassware after an experiment that had failed, found that the black sticky stuff in his beaker kept colouring the wash water purplish. Like Columbus and Saul, young Perkin had failed to find what he was COAL-TAR 51 looking for, but had hit upon something greater. He was after quinine, but he had accidentally entered the unknown field of aniline dyes and drugs, many of which are more valuable to the world than the knowledge of how to make quinine without the aid of Peruvian bark. He was working in a laboratory that he had fitted up for himself at home because the Royal College of Science was not open enough hours to satisfy him, and he was using impure chemicals. This was fortunate, for if his aniline had been pure he would have missed mauve. The first coal-tar dye, mauve, was discovered in the Easter vacation of 1856. Note the date, I mean the time of year. It is significant. Not because it was Easter, although you may have a childhood association of aniline dyes with Easter eggs. But it was in vaca- tion. It was made by a boy who played hooky from Vacation, by a boy who had rather work than eat, so he spent his noon hour fussing with chemical apparatus. There are such boys even now in spite of the fact that they are persecuted by their classmates as grinds and are not always encouraged by their teacher. I don't know how William Henry was treated by his school- mates, but he was encouraged by his teacher in the most effective fashion by being set at a discouraging task, in fact an impossible task to him, one that has not yet been accomplished — the synthesis of artificial quinine. The English and the French at first entered with enthusiasm upon the preparation of new coal-tar com- pounds, but were ultimately distanced by the Germans, 52 SCIENCE REMAKING THE WORLD who made the research laboratory a part of the factory and by thus putting their industries under scientific guidance had, before the war, obtained practically a world monopoly of the manufacture of synthetic organic chemicals. The 1914 edition of Schultz and Julius Dyestuff Tables listed 925 coal-tar dyes as used in the trade, but the chemist knows of thousands of others that he might make if needed. We already have dyes for all kinds of material and for any desired colour and shade. Some are fast and some are fugitive. Some are glaring and some are dull. Some are cheap and some are dear. Some are poisonous and some are harmless. It is ab- surd to condemn or commend the coal-tar colours as a whole, because they differ in every possible respect. That is, the dyer of to-day has a thousand pigments on his palette not counting shades and combinations. Before the discovery of mauve in 1856 — you will re- member that date if I repeat it often enough — there were barely a score of dyestuffs in general use, mostly barks and roots of uncertain composition. It is hard for us to realize what a different-looking world we are living in, thanks to coal-tar compounds, and still harder to express in words the difference in aesthetic effect. Coal-tar has brought more colour into our dull lives, not only through our clothing but also through our food. Food and drink, appropriately tinted, become more attractive, and being more attractive become more appetizing, and being more appetizing become more di- gestible, and being more digestible become more nutri- tious, and being more nutritious become more strength- COAL-TAR 53 ening. Each step in this Aristotelian sorites has, I be- lieve, been experimentally demonstrated, so it seems to lead logically to the conclusion that the increasing use of aniline dyes in food products has added to the energy of the nation. I do not put entire faith in Aristotle's logic until it is confirmed by the calori- meter, so I will not press this argument, but content myself with the safe observation that the coal-tar colours add to popular pleasure, whether or not they increase the public efficiency That they are at least harmless is assured by the United States Department of Agriculture, which analyzes every batch of dyes used in edible products to see that they are not in themselves poisonous and do not contain accidental arsenic. No new dye is added to the allowed list until it has been put through a long series of tests, first on animals, then on man, to see that it is not injurious, even in much larger amounts than are to be used in edibles. The use of artificial colours in foodstuffs is increasing rapidly. About 500,000 pounds of dyes are used every year in the United States for colouring foods and drinks. This is some four times greater than the quantity used a few years ago. The favourite colours in this field are the same as those which periodical publishers have as- certained to have the greatest selling value on the cover of a magazine, red and yellow. I leave it to the psychol- ogist to explain this popular preference for the longer wavelengths of the spectrum. The red dyes go largely into frankfurters and the yellow into butter and rival spreads, while all the colours of the rainbow are in de- mand for cake and candy icings and ice cream, and for 54 SCIENCE REMAKING THE WORLD the wide variety of soft drinks that are gi adually weaning the American people away from hard liquor. Four billion pints of bottled soda are consumed annually in the United States, not counting what is sold from foun- tains. Another indication of the popular trend toward a gayer taste is the use of chemical compounds with intent to increase the attractiveness of the naturally more at- tractive sex. The people of the United States are now spending about one hundred million dollars a year-on perfumes and cosmetics. We are importing four times as much of these, measured by cost, as we were before the war and we are exporting ten times as much. I will not attempt to apply here the syllogistic chain used above, for experimental evidence is almost alto- gether lacking. Since odours are known to have a profound influence upon the emotions, the effects of the wider use of perfumes and the introduction of new scents cannot be negligible, although they may be indetermin- able. In the manufacture of fine odours the chemist is rapid- ly catching up with the flowers; in fact has already sur- passed them in some lines. Let not the reader stick up his nose at synthetic perfumes. We could not get along without them. In fact we are altogether de- pendent upon them for certain popular forms of per- fumery, for many flowers do not give up their scent satisfactorily and so the perfumer has to imitate it as best he can. For instance, the perfumes sold under the names of arbutus, sweet peas, mayflower, cyclamen, magnolia, phlox, honeysuckle, lilac, and lily of the valley COAL-TAR 55 are not produced from the flowers, but are put together by the perfumer from chemical compounds or other floral essences. In the field of perfumes and flavours the benzene de- rivatives, natural or artificial, play a prominent part. This world would lose a large part of its delight if the "aromatics" should be deprived of the power of titillat- ing our two chemical senses, taste and smell. These six- membered carbon rings enter into all sorts of combina- tions and serve us in various ways. For instance, anthranilic acid in divers forms gives us the odour of jasmine and orange blossoms, the flavour of the grape, and the colour of indigo. Salicylic acid cures our corns and relieves our rheu- nnatJsm and in combination with the deadly "wood alcohol" (now rechristened "methanol" to keep people from drinking it) gives us the wintergreen flavour for which we Americans inherit a taste from our New England ancestors. Saccharin, a coal-tar product, is several hundred times sweeter than sugar. It is alto- gether lacking in nutritive value, but a dietary experi- ment on the largest conceivable scale, namely its daily use by many millions of Europeans for several years during the sugar shortage in the late war, should remove the popular impression acquired during the pure food campaign, that it is injurious to health. This has been recently confirmed by M. Bonjean of the Superior Council of French Public Hygiene who made a ser- ies of physiological experiments of long duration with men and dogs in all doses practically possible and found no derangement of health or digestion. 56 SCIENCE REMAKING THE WORLD The familiar phrase for anything particularly expen- sive or extravagant, "It costs like smoke," implies doubtless an unconscious realization of the fact that oxidation is the reversal of the synthetic reaction, the un- doing of the constructive activity of animate nature. The plant builds. Man utilizes. Fire destroys. Now one of the most wasteful forms of smoke was that which poured uninterruptedly during the great part of the last century from the open tops of the beehive coke ovens. In fact one can yet see these prodigal flares on the Penn- sylvania mountains as he looks out of his Pullman win- dow in the night. This is not merely a waste of fossil fuel, which we already begin to realize will not last for ever, but there is also a loss of a variety of compounds that can be made very useful if properly worked up. If a ton of bituminous coal is heated in a closed retort instead of the open beehive, we may get besides the gas and the coke, a dozen pounds of ammonium sulfate and a dozen gallons of tar. The ammonium sulfate is valu- able as a fertilizer, since it will feed nitrogen to the crops, and the tar on redistillation will yield a dozen products out of which some 200,000 distinct organic com- pounds may be made, some of which are extremely useful to mankind. There is no use crying over lost coal-tar, but the time is coming when we must be more economical. I do not want to use language instigating violence, because that is against the law, so I will merely quote Admiral Dumas, Secretary of the British Royal Commission on Oil Fuel, who said not long ago: "I would like to see a government official hanged on COM TAR 57 every lamp-post where gas is burned, because benzol goes up with the flame." He had in mind particularly the impending shortage of gasolene, for which benzol, or benzene as we call it, is a suitable substitute as motor fuel. Before the war the British were glad- to sell their sur- plus tar at low price to the Germans who made out of it all sorts of dyes and drugs which they sold back to the British at high prices. The Germans also found the stuff useful for the manufacture of high explosives which however, they were not so anxious to sell abroad but preferred to keep at home for purposes best known to themselves. We Americans, too, were neglectful of the explosive possibilities of the coal-tar products. Indeed, there was then a prevalent feeling that war was an anachron- ism and would gradually sink into innocuous desuetude. We Americans have a curious belief that anachronisms die out spontaneously if let alone, whereas history shows that they are very long-lived creatures and rarely die of old age but usually have to be killed off. In 1914 there were only enough by-product coke-ovens in the United States to turn out 700,000 pounds of toluene a month. Toluene is used in wartime for making trinitrotoluene, familiarly known as TNT, but there was not much de- mand for it then, so most of the coke makers let it burn. When America entered the war our Government per- suaded them, more or less imperatively, to put in by- product coke-ovens, and by 1918 they could turn out 12,000,000 pounds of toluene a month. The Great War differed from all former wars in the S8 SCIENCE REMAKING THE WORLD use made of high explosives; that is, compounds that can be kept and carried with comparative safety but which explode with terrific violence on being set off by a percussion cap of the right sort. The Germans with the chemical factories and nitrate plants were better prepared with these new weapons of warfare and that is why they burst through the border with such alarming speed. The steel and concrete cupolas of the Belgian and French fortresses were shattered to pieces by single shells from the 42 centimetre guns. The British trooptf had to fall back rapidly before Von Kluck's army and even then narrowly escaped destruction. Lord Kitch- ener and the British general staff were slow to realize that the old means of defence and offence were useless against the coal-tar munitions, but finally word was got to the British people that the army in France must have high explosives or perish. They got them in time to make a stand after the first German drive had spent its initial force and so coal-tar products "won the war." In considering coal-tar explosives we must not think that their usefulness is confined to settling the relative strength of nations in war. Explosives are simply com- pact packages of potential chemical energy put up in a form ready for quick release, and as such they are valuable in various ways. In 1921 the United States produced and used for industrial purposes 538,000,000 pounds of explosives. This does not include exports, but includes explosives not made from coal-tar, such as gunpowder and nitroglycerin. Carbolic acid, which the chemist calls "phenol," COAL-TAR 59 comes directly from coal tar. If this is acted upon by nitric acid, picric acid is formed, which is a dye, a drug, and an explosive. Treat picric acid with chlorine and we get chlorpicrin, one of the poison gases first used in the late war. The mother substance of this group of aromatic compounds is benzene, a colourless liquid. Treated with nitric acid this becomes nitrobenzene, and this reduced by hydrogen gives aniline, from which the innumerable and variously coloured aniline dyes are made. Acting on aniline dye with acetic acid, the acid of vinegar, gives us acetanilid, a headache remedy, or, rather, relief. Toluene, the next member of the series to benzene, can be converted by similar treatment into dyes and drugs, explosives and sedatives, perfumes and poison gas. The benzene family is remarkably versatile. What is made for one purpose often serves for another. During the war the women munition workers in England were found to be using trinitrotoluene for dyeing their hair an auburn shade, and had to be warned against the dangerous practice by an official of the Explosives Department. When we were children and played the "game of twenty questions" we always used to begin by asking "Is it animal, mineral, or vegetable?" We thought by that to corner the unknown object in one of the three kingdoms of nature, for it did not occur to us that any material thing could belong to more than one or lie outside of all three. But there are no lines in nature. What seem to us such are but merely the boundaries of our own ignorance. The synthetic products of chemical art, since they are built up from the primary elements 6o SCIENCE REMAKING THE WORLD themselves, do not properly belong to any one of the traditional three kingdoms for they may be made from material found in any of them and the product is the same whatever the source. So with the substances that we are considering. They are commonly called coal- tar products because that is the ordinary source of the raw material, for tar is a by-product of the gas and coke industry, formerly thrown away and even yet often wasted. But it is necessary to understand that there is nothing exclusive or peculiar about coal-tar. It does not contain the various valuable things that are made from it. These are mostly composed of four elements, the commonest in the world : carbon, hydrogen, oxygen, and nitrogen. These four make up air and water, and out of air and water these compounds could be made, although it would be a difficult and expensive process. ; In the chemistry books they are known either as the "aromatic compounds," because a good many of them have an aromatic odour, or the " benzene series " from the light colourless oil known as benzene which distils off when tar is heated, and which serves as the basic sub- stance of those compounds. This benzene is composed of molecules consisting of six carbon atoms hooked up into a ring. But the benzene ring and similar structures are commonly found in vegetable and animal sub- stances. The reason why I call your attention to this is that there is a prevalent impression that the coal-tar prod- ucts are some new invention of the chemists, perhaps instigated by the devil with whom chemists have always been accused of being too familiar. Many of the things COAL-TAR 61 that are now made from coal-tar were formerly ex-* tracted from plants. Indigo, for instance, has been prepared from the most ancient time out of the juice of a plant grown in India. The preparation of the dye was a toilsome process. The natives cut the plant by hand, squatting on the ground, and then beat it up in vats with paddles, standing up to their waists in the blue liquid. In 1896 there were more than a million and a half acres devoted to its culture in that country. Shortly after that the Ger- mans invented a way of making artificial indigo — no, let us say more correctly, of making indigo artifi- cially— from coal-tar, and then the land and natives of India were released for better employment. Since the war America makes her own indigo and has enough surplus to export. In 1920 there was produced in the United States more than 18,000,000 pounds of indigo, which is more than twice what we imported before the war. Next to indigo the most popular of the old vegetable dyes was madder. This has been used for more than two thousand years. It is the ground root of an Asian plant and is known as "Turkey Red." Extensive fields were given over to its culture in France and the Netherlands until 1869 when two German chemists, Graebe and Liebermann, discovered how to make the pure dyestuff, alizarin, from a waste product of coal- tar, anthracene. The artificial alizarin is better and cheaper, and this early triumph of synthetic chemistry was, at the end of the first decade of its manufacture, saving the world $20,000,000 a year, and is now saving 62 SCIENCE REMAKING THE WORLD much more than that. As Professor W. A. Noyes recently put it: "It is scarcely an exaggeration to say that enough has been saved from this to pay for all the university laboratories in the world." Let us consider another famous dye, the royal purple. You may recall what Browning says of it in the poem "Popularity." Who has not heard how Tyrian shells Enclosed the blue, that dye of dyes Whereof one drop worked miracles, And colored like Astarte's eyes Raw silk the merchant sells? Now this same royal purple that used to be extracted drop by drop from the Mediterranean mollusc may be made by the ton from coal-tar. Why is it not? Be- cause it is not good enough to satisfy modern taste. Some of the new aniline dyes are superior to it. This idea that the coal-tar products are artificial and unnatural sometimes leads to amusing consequences. In the days when the newspapers were publishing scare stories about the poisonousness of benzoic acid, an over-zealous food inspector tried to confiscate a earful of cranberries because he found benzoic acid in them. But when he attempted to get at the person responsible for putting in the forbidden preservative so that He could be properly 'punished, He was found to be too high up and powerful for the police to reach, being no less a personage than the Creator of Heaven and Earth and all that in them is. He puts benzoic acid into cran- COAL-TAR 63 berries whenever He makes them, whatever may be the law of the land. A similar instance occurred recently. The leading manufacturer of grape juice was accused of adding an- other coal-tar preservative, namely anthranilic acid, to his bottled product. But this also turned out to be a case of "natural adulteration," so to speak, for all grapes of this species contain anthranilic acid; in fact, that is what gives them their pleasant flavour. We could not rule the coal-tar products, these ben- zene compounds, out of our life if we wanted to, and we certainly do not want to, for they furnish a large part of the beauty and pleasure of the world, of the flavours of its fruits, the perfumes of its flowers, the colours of its plants. Yet you will now hear some foolish crafts- man say that we ought to do away with aniline dyes and go back to such good old vegetable colouring matters as indigo and madder. But we can beat nature at making these same things, as well as make others even more beautiful that nature cannot make. In the incessant warfare between man and microbe the human side received a powerful ally when coal-tar came to its aid, because then for the first time man could see his insidious foes. For thousands of years man had seen men and children, the strongest of the warriors and wisest of the elders, struck down by in- visibles enemies against whom he had no weapons, for he did not know what they were nor whence they came. No wonder he thought such deaths were due to the un- seen arrows of evil spirits. But by 1880 the bandage was lifted from the eyes of man, for about that time 64 SCIENCE REMAKING THE WORLD Robert Koch and others began to use aniline dyes to stain the microscopic disease germs and to catch their pictures on the photographic plate, developed by coal- tar chemicals. From that time on, as he said, dis- coveries fell into the lap of the investigator like ripe fruit. In 1882 he discovered the bacillus of tuberculosis and in the following year the bacillus of Asiatic cholera. The bacillus of typhoid fever was discovered in 1880 and in 1896 a serum was prepared to prevent it. What this has meant for public health we are all vaguely aware, but a few figures may fix our ideas. In our war with Spain where we had 107,973 men in encampments, 20,738 of them were taken down with typhoid and 1,580 of them died of it. But in 1912, when we had 12,801 men under similar conditions stationed on the Mexican border, only two cases developed, while in the Great War there were only 227 deaths from fever in all the American armies during two years. This microbe that had been the most formidable foe in previous wars has been finally conquered because we know where it lives and how it is carried and can even prepare the body in advance to resist it, if in spite of our precautions it gains entrace. It is not a matter of chance that certain dyes have been found valuable as drugs. The same thing that makes them good dyes makes them good medicines; that is, their ability to attach themselves to some par- ticular kind of animal or vegetable substance. Many of our most dangerous diseases are, as we now know, due to minute vegetable or animal parasites, bacteria or protozoa, that flourish in the blood and at our expense. COAL-TAR 65 But these are hard to see on a microscope slide where they are mixed up with all sorts of similar cells and tissues and may be quite invisible. It was fortunately found that the aniline dyes were useful in bringing out the various substances, for some would be stained with a particular colour while other things on the slide were unaffected. Those of you who have tried home dyeing will have found that in a piece of cloth composed of mixed cotton and wool, the dye is apt to attach itself to one kind of thread and leave the other untinted. One day Dr. Koch was being shown through the Breslau laboratories, and as he passed a table where a young student was busily engaged in staining micro- scope slides, he was told: "This is our little Ehrlich. He is a first-class stainer of tissues, but he will never pass his examinations." In fact, he never did, but his "staining of tissues" led to the new science of chemo- therapy which has given remedies for diseases hitherto incurable. He found first that fuchsine, a familiar red dye, would stain the tubercle bacilli so that they could be seen on a miscroscope slide. Later he found that these stains would act even in the living cell. He discovered that methylene blue, a common colouring matter, \vould seek out and destroy the parasite that causes the quartan type of malarial fever. With this as a clue he set about making molecules that would not only search out and attach themselves to the pernicious parasite, but carry along a dose of poison. For instance salvar- san, otherwise known as "606," or as it has been re- christened in America since the war, arsphenamine, con- sists of two aniline rings with arsenic atoms attached. 66 SCIENCE REMAKING THE WORLD The number shows the difficulty of this research, for it means that 605 failures preceded this success. The only way to get a realizing sense of the influence of the introduction of these coal-tar compounds is to pick out one of them and consider what pleasure or pain it has brought into the world, how much suffering it has caused or cured. For instance, did you ever have a headache that you relieved by aspirin or any of the other coal-tar re- medies? If so, multiply your headache by as many million times as you think other people have been so relieved and by as many years as you think people will continue to have headaches. Did you ever have a tooth pulled without, and an- other one with, the use of a local anesthetic? If so, you are in position to estimate in some degree the amount of human misery that has been eliminated by the invention of procaine (novocain) and similar pain- killers. Did you ever see an epileptic fit? Then imagine that seizure and thousands like it prevented by the use of luminal. Did you ever lose a friend from diphtheria? Then you can realize what it meant to the world that the bacterium of the disease was made visible by staining with methylene blue, so that physicians could identify it in any suspected case and administer an anti-toxic serum. Statistics are meaningless to us unless we can trans- late them into concrete terms. Who can estimate the increase in industrial efficiency COAL-TAR 67 and individual happiness caused by the abolition of malarial mosquitoes in a community whose inhabitants have shaken for generations with "fever and ague?" In many warm countries the energy of 80 per cent, of the population is being continually sapped by the hookworms which they carry about with them but which may be expelled by thymol, one of the ben- zene compounds. I quote a single minor incident in the anti-hookworm campaign from the 1921 Report of the Rockefeller Foundation: Three estates in Sumatra which, in spite of all recommendations, refused to adopt hookworm control measures, had in the course of two and one half years 4,657 admissions to the hospital. Three other estates with a laboring force of the same size which did adopt these measures had only 1,034 admissions — a difference of 78 per cent. One hospital admission represented on the average twenty- two days of treatment, which, reckoned at fifty cents a day, meant an aggregate loss of no less than 40,000 guilders during a period of only two and one half years. A striking illustration of the possible importance of a coal-tar compound comes to hand as I am writing this. The Germans are talking of trading off Bayer 205 for their lost African colonies. Bayer 205 is a secret synthetic medicine, presumably a coal-tar derivative like the previously known remedies of the sort, which is supposed to be a sure cure for the sleeping sickness. It is said to be fatal to the trypanosomes, the minute creatures with whip-like tail and spiral movement, that invade the blood of men and cattle in tropical Africa and bring them to a stupor that ends in death. These microbes are conveyed and injected by the tsetse fly, as fevers are by mosquitoes. The opening up of trade 68 SCIENCE REMAKING THE WORLD routes through Africa has carried the fly and the para- site into the heart of the dark continent and almost de- populated large areas. The white man has found his dearly bought possessions valueless because neither man nor beast could live there except under constant danger of the "pestilence that flieth by night." Vari- ous coal-tar products have been found effective against the trypanosomes. Ehrlich used trypan rose, an aniline dye, and Koch used atoxyl, an arsenic compound, but none proved a complete and permanent cure once the vicious little animals were in the blood. We may question the right of the Germans to with- hold knowledge of such a boon to humanity until they get their price for it, although the price demanded is hardly greater than the total profit that has been de- rived from other remedies and not by Germans alone. We may surmise, too, that the Germans could not keep the secret of Bayer 205 very long anyway, for if the drug comes into general use somebody will analyze it, what- ever the promises under which it may be supplied. Or the pharmacologists of other countries would in time work out the formula for themselves since they already can give a shrewd guess at what sort of a substance it is. But assuming that Bayer 205 is all that is claimed for it and will rid Africa of its plague and that Germans have a monopoly of it, then the British, French, and Belgians could well afford to trade off to Germany a large part of the immense territories they won by the war, for the value of the remainder would be immeasur- ably enhanced. It is not at all likely that such a bar- gain will be struck, but the mere fact that it has been COAL-TAR 69 suggested shows that a single coal-tar compound might have a value that would make it a factor of importance in international relations. It is unnecessary to expand upon their war-time im- portance, but I must call attention to two revolutionary changes that chemical warfare has made in the balance of power. First, it has already increased the superiority of the civilized man over the savage and of the scientific and industrial nation over the ignorant and primitive. There is no longer any danger that civilized nations will be overwhelmed by barbarians, as has often happened in the past, unless indeed we hatch our own barbarians in our midst. In ancient times, when martial prowess meant merely the muscular ability to wield a sword or spear and a fondness for fighting, the barbarian was likely to be more than a match for the civilian. But with the introduction of chemical warfare by the use of gunpowder in the I4th century, the balance turned in favour of the scientist against the savage, and the odds have increased ever since. Second, the recent development of chemical warfare in the way of high explosives and toxic gases has given the defence an advantage against the offensive and has made num- bers less important than intelligence. I picked out coal-tar as a topic because it is such un- promising material; black, smelly, sticky stuff, neither liquid nor solid but variably between, depending on the temperature, hard to handle because it could be neither poured like oil nor picked up like coal, combustible but not convenient for fuel, poisonous to fish if run into the water and offensive to folks if left on the land. It was 70 SCIENCE REMAKING THE WORLD worse than a waste product: it was a nuisance. It clogged up the gas works in the old days and could hardly be given away. When the chemist took this disagreeable stuff in hand he extracted from it, or rather prepared out of it, useful and beautiful things innumerable. Out of the strong came forth sweetness. The most dainty per- fumes, the most brilliant colours, the most potent drugs, the most violent explosives, the means of de- stroying life and extending life, and making life more en- joyable. A good chemist, like a good cook, is one who can make best use of left-overs. Yet coal-tar is not peculiar in its ability to contribute to man's needs. There are dozens of other forms of waste that might be made as valuable lying around loose. As I look out of the window for lack of an il- lustration, I see the ground covered with autumn leaves and dried weeds standing thick by the roadside. I wonder how many million tons of such vegetable matter containing all sorts of carbon compounds go to waste in the woods and wilds of the world every year without serving any other purpose than to refresh the humus of the soil. And then there is sawdust, and peanut shucks, oathulls, corncobs, straw, and the refuse from sugar factories, oil mills, and wood-pulp works; any of these and their like might well be worked up into all sorts of desirable commodities. The production of coal-tar compounds is an import- ant industry, and I have not tried to conceal its im- portance in these pages. But it is not a big business. It is one of the minor chemical industries as measured COAL-TAR 71 by financial income or avoirdupois output. It does not compare in these respects with such chemical industries as steel-making, glass-making, sugar-making, or cement- making. The coal-tar dyes manufactured in the United States in 1921 were valued at $32,40x3,000, but the chewing gum manufactured was worth — or was sold for — much more ($51,240,000 in 1919). But 1921 was an off year all around. Let us rather consider the famous year of 1920 when the United States manufactured 88,000,000 pounds of dyes valued at $95,000,000. This is nearly as much as we imported, chiefly from Germany, in 1914 when we did not have any dye industry to speak of. We exported American- made dyes in 1920 to the value of $30,000,000, which is a big advance over 1914 when we exported only $400,000 worth, and considerably higher than 1921, when we ex- ported $6,270,000 worth. Still our home industry is not yet sufficient to satisfy our needs for all kinds of dyes, so in 1921 we imported about 4,000,000 pounds of dyes valued at $5,000,000, about nine tenths of which came from Germany and Switzerland. Besides dyes, the United States manufactured in 1920 coal-tar medicinals to the amount of 5,000,000 pounds and the value of $5,700,000, and perfumes and flavours to the amount of 100,000 pounds and the value of $300,000. Whether this infant industry will thrive or decline under the new tariff law remains to be seen and does not con- ct rn us here since we are considering only the influence of these products on the world at large. The figures and facts given are sufficient to show how rapidly a new industry, created out of a waste product, can assume in- 72 SCIENCE REMAKING THE WORLD ternational importance and affect in various ways the lives of all of us. The aesthetic and emotional effects of such new factors in our civilization are doubtless more important than the material but they are more apt to be under- estimated because they cannot be figured in pounds or dollars. What, for instance, is the psychological in* fluence of the varied tints that our chemists have re- cently introduced ? On this point we should consult the sex that takes most delight in colour, or at least makes most use of it. So I quote without permission from a private letter I recently received from a professor of chemistry in one of the leading colleges for women: Our colours are so much more beautiful than those which we had formerly. I remember the first aniline dyes which were introduced when I was a little girl. "Crushed strawberry" and "raspberry" were fashionable. The colours improved greatly, but they have never since then been so beautiful as they are getting to be now. There is a whole range of colours developed by our chemists which are entirely new, all the shades of henna, of jade, Russian green, the rose colours, to mention only a few. They are much more suited to our climate, to our taste and to our fabrics than the German dyes which so often looked " dowdy." If a colour is pleasing, our chemists can introduce more varieties in it, just as has happened with henna. At first there was only one shade, now there are many more, delicate ones suited to summer skies and deeper ones for winter. The psychological effect of colour is beginning to be understood very much better now than formerly. The colours which oui chemists have introduced are so much more refining and stimulating than the old ones. A lovely colour gives an aesthetic pleasure, often- times surpassing that of music, and sometimes makes the possessor of it aspire to something higher and finer. It brings freedom with it. Coal-tar has also played a part in the development of our other aesthetic sense, the sense for sound. COAL-TAR 73 Carbolic acid, or phenol, is most familiar to us as an antiseptic for it destroys those microscopic enemies of ours that are always hanging around ready to enter any breach in the wall of our bodily citadel. But there is another use of it, not less important but much less familiar: its use in making artificial resins. Phenol unites with formaldehyde, another well-known anti- septic, and by the union of the liquid and the gas there is produced a hard solid insoluble substance, looking like amber or jet. This is called by the various manu- facturers "bakelite," "redmanol," and "condensite," and is extensively used, together with hard rubber, for the insulating parts of electrical apparatus, therefore contributing to electric light and power and to tele- phone and radio. It also is a factor in the phonograph. Various kinds of tar, asphalts, and pitch are also em- ployed in the manufacture of phonograph records; each manufacturing house has its own secret recipe. In the Edison record a thin coating of condensite on both sides of the disk receives the imprint of the spiral groove that carries the music. No synthetic phenol was made in this country before the war, and when we entered the conflict there came a sudden demand for an immense amount of it for making picric acid to be used in shells. Of course munitions came before music and the phono- graph was robbed to make explosives. The price of phenol jumped from nine cents a pound to $1.50. Edison with his accustomed energy set up a factory for making phenol artificially and had it running within a month. Others followed suit and before the war was over there was plenty. In 1918, 106,800,000 pounds 74 SCIENCE REMAKING THE WORLD of .synthetic phenol was made in America. But it was, if you remember, some time before phonograph disks recovered their former reliability. We knew the world was out of tune because our records were. In one of the numerous notebooks, in which Thomas A. Edison has recorded the ideas that flash through his fertile brain, is sketched under date of July 18, 1877, a crude cylinder with a handle and a trumpet, and this note written beneath: Just tried an experiment with diaphragm having an embossing point and held against paraffined paper moving rapidly. The speak- ing vibrations are indented nicely and there's no doubt that I shall be able to store up and reproduce automatically, at any future time, the human voice perfectly. This was a momentous day in the history of the human race, for it was the first time that inanimate nature had answered, although man had been talking for more than a hundred thousand years. But when Mr. Edison said "Hello, hello!" back came the friendly hail "Hello, hello!" from the paraffined paper. It was the first time that a man had heard his own voice, except as an echoed syllable. It was the beginning of an era of preserved speech. The invention naturally created a sensation and there war much speculation as to what would come of it. Edward Bellamy of "Looking Backward" was among the prophets and he, like most of them, saw in the phonograph the supplanter of print. It was commonly expected that our newspapers and books would be re- placed by talking machines and that we should use our *ars instead of our eyes in getting the news and perusing COAL-TAR 75 novels. Not so much was said about the phonograph as a musical instrument. I asked Mr. Edison, when he showed me that page in his notebook, if he foresaw its musical possibilities at the beginning, and he said that he did not, that he thought of it as a dictating machine, but now, he said, "I am hoping to hear Beethoven's Ninth Symphony with an orchestra of seventy-five pieces perfectly reproduced before I die." The so-called "talking machine" has had little talk- ing to do except in office work. There is little call for the canned speeches of our statesmen and little demand for recitations except certain comic monologues. The phonograph newspaper and novel have yet to appear. We shall have to substitute some sort of continuous strip for the dinner plate to allow of sufficient length. The radio with aid of coal-tar compounds has now en- tered this field and has converted the continent into one vast auditorium. In the field of music the phonograph has gone be- yond the wildest anticipations of its early days. It is the mocking-bird of musical instruments. It can imitate all of them, some with such exactness as to defy detection, some inadequately and imperfectly but suffi- ciently well to recall to our minds the original music as we may have heard it and so to give us a pleasure that is partly memory, as a monochrome sketch will recall a beautiful painting. It is only in trying to record a chorus or large orchestra that the diaphragm gets rat- tled and makes a failure. Whatever the defects and deficiencies of the phono- graph as it is, it has served as a test of taste on a nation- 76 SCIENCE REMAKING THE WORLD wide scale and a trainer of taste as well. It used to be said that only the few could appreciate the best music but we know that this is not true. For the great- est of composers are represented by some disks in the poorest collection. They may have been bought in the beginning for the looks of the thing and may at first be brought out only for high-brow visitors, but some of the family are likely in time to like them better than the flashy trashy tinkling tunes that first caught their fancy. This is the first time that good music has had an even chance in competition with poor music for popular appreciation. To rural communities, where for- merly the only music to be heard was that of a painfully played cabinet organ or of a self-taught fiddler, the pho- nograph has brought at least a hint of the possibilities of all instruments and of the characteristics of various compositions and of the peculiarities of varied players. With the phonograph has come into vogue its comple- ment, the motion picture, and soon the two are likely to be made one. As the telescope brings to us happen- ings distant in space, so the phonograph and the motion picture bring to us happenings distant in time. The motion picture film is produced with coal-tar developers so this too as well as all photography might be included among the beneficiaries of benzene. In short there is no end to the ramifications of the influence of coal-tar compounds on our daily life. GUIDE TO FURTHER READING "Chemical Discovery and Invention in the Twentieth Century," by Sir William A. Tilden. (Dutton.) Chapters XXI and XXIL COAL-TAR 77 "Creative Chemistry," by Edwin E. Slosson. (Century.) Chapters IV and VII. "Application of Dyestuffs," by J. Merritt Matthews. (Wiley.) "Dyes Classified by Intermediates," by R. Norris Shreve. (Chemical Catalogue Co.) "Dyes and Dyeing," by C. W. Pellew. (McBride.) Nontech- nical. "Manufacture of Dyes," by J. C. Cain. (Macmillan.) " Dyes and Their Application to Textile Fabrics/'" by A. J. Hall. (Pitman.) "The Story of Drugs," by H. C. Fuller. (Century.) "The Future Independence and Progress of American Medicine in the Age of Chemistry." (American Chemical Society.) "Origin and History of All the Pharmacopoeial Vegetable Drugs, Chemicals, and Preparations," by J. U. Lloyd. (American Drug Manufacturers' Association.) Reports of the United States Department of Commerce and of the United States Tariff Commission. ELECTRONS AND HOW WE USE THEM BY JOHN MILLS, M.A. Educational Director, Western Electric Company WHAT is the electron? It is to-day's ultimate element. What to-morrow's may be no one can say. In terms of it the scientist of to-day envisages all matter, all the stuff of which our universe is composed. The constant change and motion of matter, which appear as chemical or electrical or gravi- tational phenomena, are ascribed to another entity, called energy, which is the hidden motive power. A third entity is sometimes postulated to fill the broad spaces in which our tangible and ponderable matter forms mere specks. A vast ether is then assumed through which energy may be transmitted from one body to another, whether as light and heat from solar bodies or as so-called ether waves from a broadcasting radio station to the household receiving set. Matter energy, and a universal medium are the three entities in terms of which our present-day science is finding its explanations and extending its applications to human welfare. Of these the ether is the most de- batable assumption. Perhaps energy is not trans- mitted in waves through a continuous ethereal medium but hurtles through empty space like a bullet. For this 78 ELECTRONS 79 there is much evidence — too much in fact for exposition within the limits of a single chapter. Energy, the second unknown of modern science, is accepted by the physicist, not only because it is a necessary assumption in the eternal sequence of changes which occur within us and about us, but also because there is an unknown something which correlates exactly with all these changes and seems to be conserved throughout them. Whenever changes occur in the form,' chemical composition, or location of bodies of mat- ter the magnitude of the change is always definitely to be predetermined upon the assumption that this mysteri- ous energy will be constant and unchanged in amount. Its existence is an inference from the motions in- volved in the change. Only in this kinetic form is it to be detected and measured; and then, of course, only by the motions of ponderable matter. Between such occa- sions it masks its potentialities and appears as harmless as the explosive shell, the high-tension electric wires, or the reservoir of still water in the hills above the hydro- electric plant. But when released, the magnitude of the changes which occur shows that it has not been altered by quiescence. In a science where the ether is a convenient postulate, and energy a formless unknown, the electron stands out in stark reality as a definite ponderable particle, the tiny material element of the universe. Its identification in 1897 by Professor J. J. Thomson followed close upon the discoveries of radium and X-rays to which it now furnishes the mechanism for a valid explanation. The quarter of a century since his 8o SCIENCE REMAKING THE WORLD definite experiments has been enriched by thousands of delicate researches and the verification of ingenious theories. In the first place there has been proved the existence of a counterpart to the electron, a complementary par- ticle, conveniently known to-day as the "proton." In the original literature the proton is called a positive electron, the term deriving from the earlier and arbi- trary classification of electricity as positive or negative. Of protons and electrons all known kinds of matter are composed. More than that, these elementary particles are the positive and negative electricities which were earlier assumed to explain electrical phenomena. So now we say that matter is granular in structure and electrical in nature, although we might equally well say that electricity is granular and material. These positive and negative specks follow the well- known electrical laws: like particles repelling each other and unlike attracting. Their actions (manifestations of energy), appear as if they were the result of two urges for both of which a common satisfaction is only rarely attained. One is toward the assembling in any region of equal numbers of protons and electrons, that is, a tendency toward an unelectrified condition. Protons are attracted toward regions where there are more electrons than protons, and vice versa. Bodies com- posed of more protons than electrons are called posi- tively charged; and similarly an excess of electrons is the state of a negatively charged body. The uncharged, or neutral, condition with equal numbers is the stable condition. ELECTRONS 81 The other urge, instead of depending as does the first upon the mutual attraction of protons and electrons, depends upon the mutual repulsions which occur be- tween two or more protons or between two or more electrons. In any grouping of several protons and electrons there are some amenities in the way of proper separations between mutually repellent members. Cer- tain configurations, or arrangements of the particles in space, seem to be more stable than others and toward such configurations this second urge is effective. One of the most stable groups comprises four protons and four electrons, satisfying thereby the more funda- mental urge of equal numbers. All of these, except two electrons, are closely grouped into a tiny particle, known as an "alpha particle." Why and how four protons and two electrons should group so closely no one as yet knows. (Perhaps, at such infinitely small and sub- atomic distances, it has been suggested, the laws of attraction and repulsion do not follow the same mathe- matical relationship as they do for the larger distances at which they were determined.) The two remaining electrons disport themselves at some distance and presumably on opposite sides of the alpha particle, which attracts them because it has an excess of protons. The entire group is known as an atom of helium, that inert gas which has been recommended for airships. In this grouping both urges find complete satisfaction. No greater satisfaction could be obtained by any ar- rangement; so there is no residual tendency to join with other protons and electrons to form a larger but more stable group. 82 SCIENCE REMAKING THE WORLD In the helium atom we have the characteristic struc- ture of all atomic systems. At the centre there is a nuclear particle composed of a close arrangement of protons and electrons but including more protons than electrons. In the region beyond there are electrons. The whole constitutes a miniature celestial system in which the nucleus is the central mass and the remaining electrons planetary satellites. Atomic structure is more completely illustrated by the familar nitrogen of which we daily breathe about four times as much as we do of oxygen. Its nucleus contains seven more protons than electrons; in fact fourteen protons and seven electrons. About this nucleus are seven planetary electrons. Two of these apparently occupy positions on opposite sides like the satellites in the helium atom; and the remaining five, at a greater distance from the nucleus, are disposed as if on an imaginary sphere about the nuclear centre. How much of this well-ordered picture is speculation? Relatively little. Admitting that the evidence is not direct but circumstantial and that the positions of the planetary electrons are not exactly known, the state- ment stands as made. The evidence, however, may well wait the presentation of further facts and some ideas as to the magnitudes involved. Imagine this atom of nitrogen which consists of seven specks in space enclosing imperfectly a central speck, for the atom is mostly hole — imagine it magnified about one hundred thousand times. The specks would then be about as large as the unmagnified atom. Two such atoms of nitrogen, associated much like partners in *>, £lectro Ntgaffr* From "Within the Atom," by John Mills. Published by D. Van Nostrand Company Atomic systems at the periodic table. Place numbers correspond to atomic numbers. Systems similarly situated, as indicated by radial lines, have similar chemical properties 83 84 SCIENCE REMAKING THE WORLD polite dancing, form a molecule of nitrogen. Of such mol- ecules you inhale with each breath a few score billion, to say nothing about one fourth as many oxygen mole- cules each formed of two atoms. In the air around you all these molecules are moving at about one thou- sand miles an hour, in a haphazard way, for on the aver- age each can travel less than one thousandth of an inch before it must dodge another. That means a change of front about fifty million times a second, and estab- lishes a world's record in expediency. Now imagine a cube of this air about three eighths of an inch on a side, a cubic centimeter. Let the cube and its contents grow until its edge would reach from New York to Cleveland. Then about every foot along the way there would be a molecule; but you could not ex- pect to see one because it would be only a few tiny specks, each speck about one hundred thousandth of an inch. Nitrogen has an excess of seven protons in each atomic nucleus. Helium has two. So far as concerns an excess of protons in the nucleus there are just ninety- two possible conditions, extending from a nucleus of one proton and no electrons to the condition of ninety-two more protons in the nucleus. Whether or not there ever were any nuclei with an excess of more than ninety- two no one knows. If there were in the early geologic ages, they have now disappeared, for nuclei with more than eighty-two excess protons spontaneously disinte- grate. This is the secret of the radioactive elements of which radium is the widest known, but uranium and thorium are the unrelated parents. ELECTRONS 85 Uranium, a chemical element of which the atomic nucleus has an excess of ninety-two protons, has a most unstable internal situation. Every little while some atom of uranium will yield to the strain and expel from its nucleus a whole group of protons and electrons, THC L OriC LY C"L fCT/TOf* 9 • • • . • * - * . y • • • V • X^ • * tWCLCVS (~~ *-, r,-*r»,%f S/Y aorn THC 3000 Gftnc OUT* fft/CLCUS £: rvofte: £rL£CT*of • • /^ • • • • • ' • « • MOT From "Letter, of a Radio- /Oft Engineer to H« Son," by John Mills. Published by Harcourt, Brace and Com- fTOt-fCVLC Of pany. Inc. /Uf*1 C ft 1.0*1 DC W. 1 7-15 t/f closely associated and forming the so-called alpha par- ticle. When it has done so the nucleus contains four less protons and two less electrons, making a net excess of ninety. During the process the number of planetary electrons is reduced from ninety-two to ninety, to cor- 86 SCIENCE REMAKING THE WORLD respond to the reduced attraction of the nucleus. The result is the formation of an atom of an entirely different chemical element with different chemical properties. This process has continued for ages, gradually de- creasing the supply of uranium. In its place are its disintegration products, uranium X», so-called, and helium because the emitted alpha particle soon finds two electrons to act as its planets and with them settles down to the uncompanionable existence of a helium atom. The expulsion of an alpha particle from a uranium atom fails, however, to cure its internal troubles. Two electrons are therefore successively expelled from the nucleus of the newly formed uranium X,. The excess of protons in the nucleus is increased from ninety to ninety-one and then to ninety-two. The expelled electrons shoot into space with enormous velocity, but their independent careers are not our present concern. With their leaving, the nucleus returns to a condition of ninety-two excess protons. Thereafter it is a spend- thrift, losing one alpha particle after another until it finally becomes identical with the nucleus of the lead atom, which has an excess of eighty-two. During its downward progress it serves for a time as the nucleus of the well-advertised radium atom. The radioactive elements are responsible for much of our present-day knowledge of electronic physics. They gave away the inner secrets of a large group of atoms to such ingenious and persistent investigators as Professors Rutherford and Soddy. It was the former, for example, who proved that the alpha particle is really ELECTRONS 87 the kernel of the helium atom. He used a glass tube with a deep dimple in one side. First he tested the atmosphere within the tube for the presence of helium and found none. Then in the dimple he placed a radio- active substance. Again he tested; and helium was then present. The enormous velocities of the alpha particles had carried them through the glass wall into the enclosed space, where they showed in the spectro- scope the lines which are characteristic of helium. More recently Professor Rutherford has let these alpha particles shoot through nitrogen gas. Imagine, if you care to, some enormously solid comet plunging into our solar system so rapidly as not to perturb our planet until the fatal moment when it collides with the sun. The violent impacts of alpha particles and nuclei of nitrogen were relatively infrequent since both are very tiny; but when they occurred the nitrogen atom was disrupted and some of the protons knocked out of its nucleus. There is dove-tailing evidence enough on all these matters to require several graduate courses in physics for its exposition, so the reader whose time is limited must accept it on faith. He might justly ask, however, how these protons were recognized? By the distance they were knocked ! And the reason is this : Alpha par- ticles rushing from their former nuclear homes will penetrate a fairly definite distance in air before they are so slowed down that they will not produce little scin- tillations when they strike a properly prepared screen. If instead of air they rush through an atmosphere of hydrogen gas the effect is the same except that occa- 88 SCIENCE REMAKING THE WORLD sional scintillations may be observed at a much greater distance from the radioactive material. Now, hydro- gen has long been known to be an atom with a single proton for a nucleus and, of course, one planetary elec- tron. These scintillations are due to these protons which, being lighter than the alpha particles, are thrown farther by the collision. When pure nitrogen is used there are occasional scintillations at that greater dis- tance which corresponds to a single proton being pro- jected forward by the collision. In the radioactive atoms the nucleus is most expres- sive but in all atoms it is the real determining influence. Upon it depends the number of planetary electrons, for their number is normally equal to the excess of pro- tons in the nucleus. Upon this number depends the configuration and that determines the chemical behav- iour of the atom. In final analysis the nuclear content makes the atom what it is. For that reason it is con- venient to classify on a purely numerical basis by the "atomic number" which states the excess of protons in the nucleus. For purposes of visualizing the chemical behaviour of atoms it is simplest to deal with those of atomic numbers n and 17 which are sodium and chlorine, respectively. Now it happens that the atom of atomic number 10 is that of neon, an inert gas, much like helium except heavier, which is completely satisfied. The atomic number 18 denotes another satisfied structure, that of argon. Sodium and chlorine, however, were created without the complete satisfaction of both the urges which were mentioned earlier. Sodium has one ELECTRONS 89 planetary electron too many for a really satisfactory configuration such as is represented by the planetary electrons in the neon atom. Chlorine on the other hand lacks one electron of the eighteen which would assume the stable arrangement of the argon atom. A sodium atom is like a human being wrought upon by two conflicting emotions. If it should lose a planet- ary electron its remaining satellites would have a satis- fied configuration, but the urge for an equal number of protons and electrons would then be effective and the atom would merely have changed the kind of its dis- content. On the other hand, the chlorine atom would be better off with an additional electron in its planetary spheres, if it were not that, for it also, the urge of equal- ity and electrical neutrality would then be dominant. One has an electron to lose : the other, one to gain. They meet apparently on the same plane of mutual profit as do buyer and seller in the ideal case of business trans- actions. An electron is transferred. But neither buyer nor seller dares balance his books thereafter. The only solution is to remain together so that for pur- poses of accountancy the transaction may be considered incomplete and yet both may have the satisfaction which is the profit. This seems to be the basis of the existence in combination of a sodium and a chlorine atom as a molecule of sodium chloride, the common salt of the table. In fact, in a crystal of salt the various atoms are arranged in orderly rows in such a manner as to make the accountancy surprisingly satisfactory to each atom. Above and below, in front and behind,' to right and left of each sodium atom there is one of 90 SCIENCE REMAKING THE WORLD chlorine; and the converse is true of each chlorine atom. In the confusion, however, which occurs when salt is dissolved in water the necessity of balancing accounts is momentarily forgotten. The chlorine nucleus moves out into free space between the water molecules, taking with it as an extra satellite an electron from the sodium. The sodium nucleus starts off on its wanderings with one too few electrons. From that time on each is an "ion," an electrically charged particle, seeking a means of balancing its electronic accounts. In its wanderings it may meet with another and oppositely charged ion but the association and consequent satisfaction are only transient because the fluid milieu in which they find themselves encourages incompatibility. (Of course, if there is too little water crystallization occurs.) If molecules of some other substance, which also dis- sociates into ions, have been dissolved in the same water these ions may afford satisfaction to the ions formed from the salt. A positive ion, that is one which has lost an electron, will always welcome a meeting with a negative ion for the latter has too many electrons. Combinations into molecules occur between atomic systems, that is atoms or ions, either under the urge of attaining greater satisfaction of configuration for the planetary electrons or under the urge of becoming elec- trically neutral. (In the non-chemical phenomena of electricity it is the second urge which is responsible.) The un satisfactions which lead to activities may involve more than one electron for each atom, instead of just one as in the simple case of sodium and chlorine. Com- plicated molecular unions may, therefore, be formed ELECTRONS 91 comprised of many atoms, which as individuals may have had urges of different degrees of intensity. The chlorine atom which serves for visualizing chem- ical activity will also illustrate one fact which remains to be expressed before the picture is complete. Chlor- ine is a substance well known to the chemist. In our modern terms it is the element of atomic number 17, that is, it contains in its nucleus seventeen more protons than electrons. Its atomic number states a difference; but what about the actual content of the nucleus? In the first place we know the masses of the proton and electron. The proton is about eighteen hundred and fifty times greater in mass than the electron. It is, therefore, responsibile for the weight of discrete atoms and of their aggregations in such masses as we weigh on chemists' balances or coal-scales. The weight of a helium atom which contains four protons in its nucleus should then be practically four times that of the hydro- gen atom which has a single proton for its nucleus. Oxygen, which is known to contain sixteen protons, is approximately sixteen times as heavy as the hydrogen atom. The masses of various atoms have been found by an electrical method by Professor J. J. Thomson and more recently by Dr. F. W. Aston. The method involved ionizing the atoms, that is removing from them one or more electrons. Due to the resulting electrified condi- tion the atom will respond to electrical attractions and repulsions. The amount of its motion may then be used as a measure of its mass just as you might measure masses by observing what motions you could give to 92 SCIENCE REMAKING THE WORLD them with a definite muscular force. As to knocking electrons off from atoms, and thus ionizing, there are many ways but they are not our present concern. The important point is that because of the electrical nature of the tiny particles which compose atoms it becomes possible not only to determine the masses of the atoms but also to separate atoms by weight. The chemist has always separated atoms on the cri- terion of chemical behaviour, that is, unconsciously un- til recently, on the basis of atomic number. For atoms so separated there have long been available very accurate determinations of the relative weights of the atoms of different chemical elements. The results of the elec- tronic physicist agree with these in those cases where the chemist had found for the atomic weight a whole number, when compared to the weight of the oxygen atom assumed as sixteen. The weights should be re- lated as integers since the nucleus should contain whole numbers of protons. The chemical method determined the average atomic weight of a large number of atoms of a chemically pure element. The physical method could be applied to a mixture of elements and would separate the atoms according to their weight. The chemical method applied to chlorine obtained an atomic weight of 35.45 on a scale where the oxygen atom was 16.00. The physical method applied to chlorine indicated a mixture of two distinct types of atoms, one with a weight of 35 and the other with a weight of 37. There were ap- parently in any sample of chemically pure chlorine about three times as many atoms with weights of 35 ELECTRONS 93 as there were with weights of 37. On the average such a mixture would then have the weight indicated by the chemical method. Two kinds of atoms, differing in the total number of protons, were thus found to possess the characteristic behaviour of chlorine. They are called "isotopes" of each other because they occupy in the chemical tables the same position. The term was introduced by Pro- fessor Soddy who has met a similar phenomenon in his study of the chemistry of the radioactive elements. The case of uranium which was cited earlier will illus- trate it. Uranium loses from its nucleus successively an alpha particle and two electrons. Thereby it has reduced its nuclear content by four protons and four electrons. The atomic number of the new element, uranium II, is the same as uranium; the chemical behaviour is the same although, of course, the radio- activity is different; but the atomic weight is reduced by four units. The new element is an isotope of the old, chemically identical, but with a lower atomic weight. Such is a brief outline of the present ideas as to the matter of which our universe is composed. It is gran- ular in structure and electrical in nature, being com- posed of definite specks. Upon the number and arrangement of these specks, protons and electrons, depend all the physical and chemical characteristics of matter. Instead of classifying matter inexactly by the average behaviour of a number of atoms it is now possible to extend a rigorous and numerical classification to individ- 94 SCIENCE REMAKING THE WORLD ual atoms. The key to the atom is its nuclear composi- tion. Its weight depends upon the number of protons in its nucleus. Its normal possibilities of combination into molecular form, that is, its chemical properties, depend upon the excess of protons in the nucleus. That From "Letters of a Radio-Engineer to His Son," by John Mills. Published by Harcourt, Brace and Company, IDC. The Thermionic Vacuum Tube. Electrons emitted by a heated fila- ment, F, are drawn across a highly evacuated space to a plate, P. The stream is very sensitive to changes in the electrical potential of the grid, G. The device is widely used in the Bell System as an amplifier of telephone currents determines what is its normal complement of planetary electrons and their configuration. In terms of excess protons in the nucleus, that is, the so-called atomic number, there are ninety-two classes, of which eighty-seven are known chemical elements. In each class, however, there may be required a further subdivision on the basis of total number of protons in the nucleus. In addition, although the point has not previously been developed, there may be a difference in nuclear history which predisposes a nucleus to one ELECTRONS 95 course of degradation rather than another. This is true of certain of the radioactive elements, where atoms of the same atomic weight as well as of the same atomic number may follow different sequences of radioactive changes. Whenever the number of planetary electrons about a nucleus does not correspond to the atomic number, then the atomic system is electrically charged, that is, "ionized/* Its further activities are due to that charge and the atom is under the urge of restoring a state of electrical equilibrium. Of such activities there are too many for present mention. They accompany any de- rangement of the planetary electrons and to them are due many of the phenomena of light and X-rays. A current of electricity exists whenever there is a stream of electrons from one point to another. In con- duction through gases the gas must be ionized before it becomes conducting. Its molecules must be split apart in some manner which will result in the formation of ions, that is, atomic or molecular systems which have more or less than the normal number of electrons. Such ionization may be accomplished in a number of ways, by the action of ultra-violet light, by exposure of the gas to X-rays, by impacts with swiftly moving electrons or alpha particles from radioactive substances, or by collision with swiftly moving free electrons or ions how- ever obtained. Under these conditions some of the gaseous molecules lose by impact planetary electrons and thus become positive ions. The freed electrons immediately take up their way toward the positive elec- trode and the positive ions take the opposite way 96 SCIENCE REMAKING THE WORLD toward the negative electrode. Both may produce further ions from the normal molecules of gas with which they collide if the impacts are sufficiently violent. Such, in general, is the phenomenon of conduction through gases. In solid bodies, like wires, conduction occurs by the motion of free electrons which wander this way and that through the intermolecular or interatomic spaces. The metals, the best conductors, are electro- positive, that is, their atoms are systems with incon- venient electrons in excess of the simplest configura- tional requirement but not in excess of the number of protons in the atoms. It is these loosely held electrons, most probably, which serve to conduct electricity through solid conductors. Their haphazard wander- ings are superseded by a definite drift when the ter- minals of the solid are connected to a battery. This phenomenon of electron streams in wires con- ducting electricity is made to furnish the electrons which form the stream through the vacuum of an audion. The audion consists of an evacuated vessel with a filament through which a current of electricity may be passed. There is also a metal plate and be- tween the plate and the filament a fine wire-grid. A strong current of electricity through the filament is manifested by its rise in temperature and its lumines- cence. Both the heat and the light are due to the dis- turbances created among the atoms of the wire by the stream of electrons which constitutes the current. The individual electrons of the stream, which is being forced through the filament by an external battery, must dodge or jostle their way past the more fixed atomic systems ELECTRONS 97 and the stay-at-home electrons. They move with considerable velocities and from time to time one is diverted from the straight path of the conductor and flies beyond the restricting influence of its protons to the free space surrounding the filament. The number that thus escape is very large, increasingly so at high temperatures of the filament. Another battery is connected to the audion in such a manner as to make the plate positive with respect to the filament. The free electrons are then drawn across the vacuum from filament to plate. On the way, how- ever, they pass through the meshes of the grid. The latter is strategically placed nearer the filament than the plate. Feeble electrical changes in the condition of the grid, therefore, produce pronounced changes in the stream of electrons which flows from filament to plate. Changes produced in this manner will be evi- dent in the external portion of the electrical circuit which is formed by the second battery, the filament, the plate, and the intervening vacuum. The small inertia of these individual electrons and the delicacy with which the strategically placed grid controls their actions have resulted in the marvellous application of the audion to the electrical communication of speech by wire and by radio. GUIDE TO FURTHER READING " Matter and Energy," by Frederick Soddy. (Henry Holt.) 1912. ' nee and Life," by Frederick Soddy. (John Murray.) 1920. "Within the Atom," by John Mills. (D. Van Nostrand and Co.) 1922. 98 SCIENCE REMAKING THE WORLD "Letters of a Radio-Engineer to His Son," by John Mills. (Har- court, Brace & Co.) 1922. "Molecular Physics," by James A. Crowther. (P. Blakiston's Son & Co., Phila.) 1919. "Chemistry and Its Borderland," by Alfred W. Stewart. (Long- mans Green & Co.) 1914. "The Electron," by Robert A. Millikan. (Univ. of Chicago Press.) 1917. "Electrons, Electric Waves and Wireless Telephony," by J. A. Fleming. (Wireless Press.) 1922. "The Radio Pathfinder," by Richard Ranger. (Doubleday, Page &Co.) 1922. AN INVESTIGATION ON EPIDEMIC INFLUENZA BY PETER K. OLITSKY, M.D. AND FREDERICK L. GATES, M.D. The Rockefeller Institute for Medical Research EPIDEMICS of influenza have occurred at Intervals for centuries, and may be recognised from con^ temporary descriptions though they were known under different names in different places and different times. The disease has had a wide or more restricted distribution according to various circumstances of the time, especially the rapidity and extent of the move- ments of men. Thus in earlier centuries human trans- port carried the pestilence slowly and over limited areas; in modern times, in a world knit closely together with frequent and rapid means of migration, the disease passes quickly from country to country and from con- tinent to continent. During the World War it quickly exacted a death toll from the warring countries surpass- ing their losses under arms. The place or places of origin of the epidemics are still under investigation, and it remains for future study to determine whether the spread takes place from a single source or from many. History traces the outbreaks of many epidemics to regions of eastern Russia and Turkestan; but indications are not wanting that in- 99 xoo SCIENCE REMAKING THE WORLT5 fluenza lurked in many centers preceding the pandemic of 1918. Which ever of these divergent places of origin proves to be the true one, certain essential conditions (as yet undiscovered) must be regarded as combining to convert smouldering inactivity into epidemic spread. THE EPIDEMIC OF 1918. — The emergency created by the epidemic outburst of 1918, which was of unparalleled severity, coincided with the exigencies of the Great War so that the full weight and force of modern methods of clinical and bacteriological study could not quickly be brought to bear upon the disease. In many instances investigators were further handicapped through failure to distinguish influenza as a primary infection from the frequent pneumonias of common bacterial origin which were secondary to it; or were prejudiced in their views by the general acceptance of Pfeiffer's bacillus as the bacterial cause of influenza. This bacillus had been discovered by Richard PfeifFer during the epidemic of 1889. Early in the course of the epidemic, however, discor* dant findings cast doubt on the part played by Pfeiffer's bacillus as the cause of the disease and in many labor- atories the search was started de novo for some hitherto unknown microbe whose distribution and character would more nearly fit the requirements of the case. The results of such an investigation at the Rockefeller Institute for Medical Research are described in this chapter. DEFINITION OF EPIDEMIC INFLUENZA. — Epidemic in- fluenza free from complications is usually a mild affec- tion. On the fringes of an epidemic it is not always EPIDEMIC INFLUENZA 101 easy to distinguish it from other indefinite ailments of the upper respiratory tract. In the midst of an epi- demic, however, when many similar cases may be seen, its manifestations are more obvious and uniform. The attack is usually sudden with a chill, or chilly sensations* and fever. Headache, frontal or general, develops, with pains in the back, joints, and extremities. In the severer cases the prostration that accompanies these symptoms forces the patient to bed. The eyes become inflamed and painfully sensitive to light. The face is. flushed; the throat swollen and raw, a thin irritating secretion flows from the nose, and the progress of the infection is denoted by hoarseness and a dry and dis- tressing bronchial cough. Examination of the chest,. however, reveals no certain signs of lung involvement. Other organs are not usually obviously affected. Pulse and respiration are only slightly accelerated. The temperature remains fairly constant, between 101.5 and 103° F. for two to four days and, then after a pro- fuse perspiration, it falls rapidly to normal (about 98.5° F.) with the beginning of convalescence. The duration of uncomplicated influenza is usually one to three days; in the severer cases four to six days. When symptoms persist beyond this period a secondary pneumonia or seme other sequel is to be suspected. Peculiar features of the disease are an early drop in the circulating white blood cells, a lowering of the resis- tance of the lungs to secondary infection by common bacteria, resulting in a high incidence of severe and ffctal secondary pneumonias, and the persistence of a profound physical and mental depression during con- 102 SCIENCE REMAKING THE WORLD valescence. Characteristic of an epidemic is the rapid spread, coupled with a high incidence of infection, so that more than half a population may be attacked in the first wave, and the recurrence of successive waves of diminishing extent and severity until, in the course of three or four years, the epidemic dies out. EXPERIMENTAL INOCULATIONS. — In September, 1918, when it was decided to undertake a search for the in- fectious agent of epidemic influenza in the laboratories of the Rockefeller Institute for Medical Research, methods of transmitting the infection to animals were first considered, because an experimental infection in animals offers facilities for study not obtainable in human cases. For example, the transmission of a transient disease such as influenza through animals insures its indefinite propagation and affords material for study after human sources fail. An infection in laboratory animals can be interrupted at any time for necessary examinations of its progress and offers many avenues of approach which are closed to the investigator if he must depend wholly upon human cases for study. Uncomplicated influenza, however, is a relatively mild disease in man and some of its prominent manifes- tations such as chills, headache, sore throat, and de- pression cannot be observed in animals. It was ex-i pected that the experimental disease, if successfully established in animals, would be mild as well, and might be missed unless some definite, measurable cri- teria could be employed to indicate the development of abnormal conditions similar to those observed in human <:ases. It was thought that among the characteristic EPIDEMIC INFLUENZA 103 signs of the human infection, the typical changes in the blood might be used as an indication of successful trans- mission and it appeared probable that some local injury might be found in the lungs of the animals which would account for the characteristic defect in the resistance of the lungs following human influenza. Influenza is transmitted from person to person by the secretions of the respiratory tract, so the first experi- ments were undertaken with washings from the noses and throats of human patients in the early hours of the disease. These washings of course contained many varieties of bacteria, but it was expected that in favour- able instances the ordinary bacteria of the nose and throat would be suppressed through the natural resis- tance of the animal and that the specific effects of an extraordinary microbe might thereby be revealed. In a short series of experiments monkeys were found to be unsuitable for use in the study of influenza both because of their scarcity and because of the frequent presence of pulmonary tuberculosis in the available monkeys. These preliminary experiments, however, gave a clue to a method of injecting the nasal washings which promised definite results. Injections of the washings into the nose and throat, the eyes, the blood, and under the skin produced no distinctive effects. But when the injections were made into the trachea, so that the material ran down into the lungs, the mon- keys showed a decrease in the white cells of the blood, such as is characteristic of human influenza. This suggestive sign could not be correlated with local dam- age to the lungs, however, because of the frequency io4 SCIENCE REMAKING THE WORLD of diseased conditions due to other causes. The rabbit was then chosen for further experiments. The results of the first injections of nasal washings from human influenza patients into the lungs of rabbits showed that something in the washings was producing definite and characteristic effects. On the first or second day after injection the rabbits appeared ill, with ruffled fur, inflamed eyes and usually a degree or two of fever. The constant feature of their illness was a sudden drop in certain of the white cells of the blood which fell to half or a quarter of their normal number. These effects were transitory, and after two or three days the animals recovered. If the animals were killed for examination at the height of the attack, their lungs showed evidences of a definite type of injury and dis- organization unlike that found in ordinary pneumonia but similar in many respects to the influenzal damage found in persons dying early in the disease. Usually no ordinary bacteria could be recovered from the in- jured rabbits' lungs and it appeared that the effects pro- duced by the human nasal washings were independent of the presence of commonly recognized microbes. By injecting into the lungs a suspension of ground lung tissue from a previously affected rabbit the typical effects just described could be induced successively in a series of animals. In one instance fifteen successive transmissions were obtained before the experiment was discontinued. The persistence of these characteristic results, in spite of the repeated dilution of the original material between transmissions, indicated the presence of a self-perpetuating agent; a living organism or virus. EPIDEMIC INFLUENZA 105 The next step was to define the living agent more exactly and to attempt its cultivation in the laboratory. It was soon found to be so minute that it readily passed through earthenware filters impervious to ordinary bacteria. In this way it could be separated from other microbes in the human nasal washings or in affected rabbits' lungs. Filtered nasal washings from influenza patients and filtered lung suspensions produced the typical train of effects in rabbits and thus proved that ordinary bacteria were not involved in the process. The specific microbe, which as yet had not been seen but whose presence was clearly indicated by the animal experiments, was a "filter-passer." Now although very few filter-passing microbes have been identified, the group, in general, has certain well-known characteristics which this virus was found to share. For example, although it was readily killed by heat at 133-140° F., temperatures often used in pasteurization, it was resis- tant to drying or freezing and could withstand the action of 50 per cent, glycerine for periods up to nine months. When animal tissues containing it were con- taminated by moulds or bacteria, the virus still survived. Another noteworthy effect of this active agent early claimed attention. When unfiltered nasal washings from influenza patients were injected into rabbits* lungs, other microbic residents of the nose and throat were likewise deposited. Ordinarily such bacteria do not do any damage under these conditions but are over- powered by the active protective mechanisms of the body. But in the presence of the primary injury caused by the influenzal agent these bacteria were sometimes io6 SCIENCE REMAKING THE WORLD able to multiply and cause severe pneumonias. The similarity of these accidental infections in the experi- mental animals to the secondary pneumonias in man led to a series of experiments to put this significant train of events to further test. These experiments proved that a decrease in the re- sistance of the lungs to common bacteria was a charac- teristic result of infection with the filterable virus. After the lungs had been damaged by the influenzal agent the other organisms were injected into the trachea or into the blood stream, and from both sources the common bacteria invaded the injured lungs and there induced a typical pneumonia. To the normal lungs of healthy or "control" animals the same doses of these microbes were harmless. The first object of the investigation had now been accomplished. An infectious agent, present only in the nasal washings of influenza patients in the early hours of the disease, had been transmitted to laboratory animals and could now be studied under experimental conditions. The presence of this virus induced changes in the blood that are typical of the blood changes in human influenza. And the lungs of the infected rabbits were found to be the site of typical injuries, which pre- disposed them to severe and fatal pneumonias. ARTIFICIAL CULTIVATION. — From the beginning of the investigation, while the first animal transmission experiments were in progress, attempts were made to isolate the active agent in artificial cultures outside the body. For this purpose the usual methods of cultiva- tion were discarded in favour of the particular methods EPIDEMIC INFLUENZA 107 developed by Doctor Noguchi, based on the early ex- periments of Doctor Theobald Smith. The Smith- Noguchi culture medium, which had proved successful in the cultivation of certain highly parasitic microbes, consists of dilute blood serum or tissue fluid with a small fragment of fresh sterile tissue — usually rabbit kidney — and is thus very different from the artificial broths and jellies commonly employed in bacteriology. Besides furnishing nutritive substances the tissue frag- ment creates an environment favourable to those pe- culiar "anaerobic" microorganisms which can live only in the absence of air. The choice of this medium for the cultivation of the active agent of the animal trans- mission experiments proved to be a fortunate one. In November, 1918, certain extremely minute but characteristic spindle-shaped bodies were observed in strictly anaerobic cultures of the filtered nasal washings of an influenza patient in the early hours of the disease. In size they approached the limit of vision with the high- est powers of the microscope so that the sparse growths in the early cultures were identified with the greatest difficulty. Soon, however, other cultures were ob- tained, both from the filtered nasal washings of other influenza patients and from the whole or filtered lung- tissue specimens of rabbits which had been typically affected by these secretions, as has been described. As these minute microorganisms were carried through successive generations of culture, they became better adapted to artificial cultivation and multiplied more luxuriantly, so that the cultures could be used in animal experiments with unequivocal results. These experi- io8 SCIENCE REMAKING THE WORLD ments proved beyond question the identity of the active agent obtained from influenza cases and the bodies obtained in culture. Both were derived from the same sources. Both were filterable. Both pro- duced identical effects in rabbits, and from the pulmon* ary lesions produced by either, further animal passages, or cultures, could be obtained. Both, protected by bits of affected lung tissues, withstood 50 per cent, glycerine for periods of months. Both had that curious property of damaging the lung in such a way as to lower its resistance to secondary invasion with ordinary bac- teria. It was from this character that the microbe, objectively, received its name. It was called Bacterium pneumosintes — a bacterium that injures the lung. Finally, conclusive evidence of the identity of Bacterium pneumosintes and the virus from the human nasal washings was furnished by a series of experiments which showed that a previous infection with either one of these pathogenic agents rendered an animal immune to attack by the other. IMMUNITY. — In many infectious diseases, the im- munity conferred by an attack is associated with the appearance in the blood of specific principles, or "anti- bodies," which can be demonstrated by serum tests. Efforts were therefore directed toward the observation of antibodies in the blood of experimentally infected rabbits, and of influenza patients, from which the strains of Bacterium pneumosintes ultimately had been derived. But it was found that cultures of Bacterium pneumosintes in the Smith-Noguchi medium were un- suitable for such experiments. The sparse growth of EPIDEMIC INFLUENZA 109 the earlier generations was mixed with protein precipi- tate that interfered with the reactions and had proper- ties that precluded its use. It was therefore necessary to devise special methods of cultivation, and before these methods became available the first opportunity was lost to test for antibodies in the blood of influenza patients and of affected rabbits. It was found later that if the Smith-Noguchi medium was enclosed in a collodion sac, surrounded by distilled water or physiological salt solution, anaerobic conditions were shortly established throughout the system and the nutritive and growth-promoting substances of the medium diffused through the membrane in sufficient quantities to support a luxuriant growth in the surround- ing liquid. The protein precipitate that collected around the tissue fragment was retained within the sac. When it was possible to cultivate Bacterium pneumo- sintes by this method in quantities sufficient for use, rabbits were repeatedly injected with small doses of live cultures, or of heat-killed organisms. After a suit- able interval, their blood serum was found to possess specific antibodies against Bacterium pneumosintes. A significant feature of the immunity experiments and also of these serum tests was the fact that all the strains tested had similar properties and reacted iden- tically with the specific antibodies produced by any one of them. This is what would be expected if they were all derived from a common source. The experiments described above based on the epidemic of 1918-1919 and the recurrence of 1920, had extended over three years and the facts had been care- no SCIENCE REMAKING THE WORLD fully controlled, and checked by repetition. They could not be further extended, however, without fresh material from influenza cases and for some time it was not possible to determine whether the blood of influenza patients contained specific protective substances against Bacterium pneumosintes, or whether protection might be afforded by subcutaneous injections of the killed organism — a method of prevention that has proved so efficacious against typhoid fever. An opportunity for further study was finally provided by a recurrence of epidemic influenza in New York City in January and 'February, 1922. With material obtained from a number of early cases of influenza in this outbreak, all the essential steps in the former investigation were repeated so that this series of experiments served to check and confirm the results of the earlier work. Especially significant was the fact that the new and old strains reacted identically in specific serum tests and that rabbits immunized against the old strains were subsequently resistant to the new ones, thus proving the identity of the micro- organisms. With the 1922 strains of Bacterium pneumosintes the experiments on the blood of recovered patients and on the protection afforded by vaccination with killed cul- tures could now be carried out. In the blood tests specimens of serum were studied from nineteen persons who had recovered from influenza from ten days to five months previously, and from twenty-two other persons who gave no history of influenza since 1920. The sera of the twenty-two controls were uniformly negative in the EPIDEMIC INFLUENZA in tests. On the other hand, the serum specimens from seventeen of the nineteen persons who had influenza during the recurrence of 1922 reacted positively and thus afforded presumptive eivdence that they had recently been infected with Bacterium pneumosintes. One of the persons chosen as a control subsequently had influenza. It was interesting to find that his blood serum, previously negative, reacted positively with Bacterium pneumosintes when tested on the tenth and eighty-ninth days after recovery. In other instances demonstrable antibodies persisted in the blood for at least five months following an attack of influenza. The second series of experiments that were made possi- ble by the acquisition of new and pathogenic strains of Bacterium pneumosintes deak with the immunizing effects in rabbits of subcutaneous injections of appro- priate doses of the heat-killed organisms. When a number of rabbits had been prepared by three injections of the killed bacteria the protective effects of the vac- cination were demonstrated in two ways. By examina- tion of the blood serum it was found that eleven among fifteen vaccinated animals had developed specific antibodies against Bacterium pneumosintes. Their re- sistance was then tested to doses of the living organisms which were pathogenic for normal, unvaccinated ani- mals. In all but two instances the protection was com- plete. Not only did the vaccinated rabbits fail to show the characteristic signs of infection with Bacterium pneumosintes but, with the two exceptions noted above, they were normally resistant to secondary infection with ordinary bacteria. Incidentally, it was observed ii2 SCIENCE REMAKING THE WORLD that the doses of vaccine were well borne and did not even temporarily reduce the rabbits' resistance to other infections. These experiments therefore pointed the way to a similar series of observations in man. On the basis of these results the vaccine has been of- fered to several groups of men in the United States Army. A very wide and extended experience will be necessary, however, to determine its value, and at present nothing definite can be said as to its efficacy in the prevention of influenza. CONCLUSIONS. — As the result of this investigation at the Rockefeller Institute a hitherto undiscovered organism, Bacterium pneumosintes, has been isolated from the nose and throat secretions of influenza pa- tients in the early hours of the epidemic disease. It is filterable, anaerobic, resistant, and pathogenic for rab- bits, in which it induces a typical infection seemingly identical with epidemic influenza in man. The signifi- cant features of this experimental infection are the changes in the blood cells and the production of a characteristic injury to the lungs associated with a de- fect in their resistance to secondary invasion with common pathogenic bacteria. All the strains of Bacterium pneumosintes have similar properties, indicating a common source. Animals subjected to a primary infection, or injected with living or killed organisms, are immune to subsequent injec- tion. The killed bacteria induce specific antibody for- mation even when injected subcutaneously in doses well tolerated by man. The blood serum of recovered in- fluenza patients contains antibodies for Bacterium EPIDEMIC INFLUENZA 113 pneumosintes, whereas that of normal persons does not. These experimental observations, reported elsewhere in greater detail, especially in view of the source of the cultures, their effects in rabbits, their identity, and the presence of specific antibodies in the blood serum of re- cently recovered influenza patients, point to Bacterium pneumosintes as the bacterial incitant of epidemic in- fluenza. Moreover, many of the essential facts brought out in this study have been confirmed by Loewe and Zeman, and by Baehr and Loewe in New York, by Gor- don in England, and by Lister in South Africa. The significance of similar observations from such widely separated localities is obvious. But medical science is apparently at the threshold of knowledge of a group or class of minute microorganisms which the anaerobic Smith-Noguchi technique and more recently developed methods of cultivation have thrown open to exploit- ation. This new field of bacteriology invites further in- vestigation. It has seemed wise merely to report the experimental facts so far obtained and to defer the final decision on the precise relation which Bacterium pneu- mosintes bears to epidemic influenza until further ex- perience is obtained. GUIDE TO FURTHER READING "Twenty-five Years of Bacteriology. A Fragment of Medical Research," by Simon Flexner. Science, 1920, vol. lii, page 615. " Parasitism as a Factor in Disease," by Theobald Smith. Science, 1921, vol. liv, page 99. "Epidemiology and Recent Epidemics," by Simon Flexner. Science, 1919, vol. 1, page 317; Jour. Jmer. Mtd. Assn., 1919, voL kxiii, page 949. ii4 SCIENCE REMAKING THE WORLD "Influenza, an Epidemiologic Study," by Warren T. Vaughan. Baltimore. 1921. (Published by American Journal of Hygiene.} Influenza. Encyclopedia Britannica, I2th Edition, 1922, new vol. 31, page 488. "Influenza Studies," by R. Pearl. U. S. Public Health Reports, 1919, vol. 34, page 1743. "The Epidemiology of Influenza," by W. H. Frost. U. S. Public Health Reports, 1919, vol. 34, page 1823. , OUR PRESENT KNOWLEDGE OF TUBERCULOSIS BY LINSLY R. WILLIAMS, M.D. Managing Director, The National Tuberculosis Association, New York City DURING the lyth and i8th centuries the words "consumption" and "phthisis" were com- monly used to designate various wasting dis- eases now known to be of many varied types. In the medical literature of this period there appears frequently the word "tubercle," but what the authors meant by this word was apparently nothing more than small nodules the size of a small pea or smaller which were found from time to time in bodies that were examined. Tubercle was first described definitely by Baillie in England in 1793, who, relying on naked-eye observations, differ- entiated tubercle from other tumors and commented upon its constant appearance in autopsies of persons dying of consumption. In 1810 Bayle in Paris at- tempted to classify the different types of these tuber- cles. A few years later (1819) Laennec, the inventor of the stethoscope, showed that in autopsies made of persons dying of consumption there were found in the lungs small tubercles, agglomerations of many tuber- cles. Also he found some tubercles which had under- gone a partial degeneration; and found cavities in the walls of which small tubercles appeared. By means of "S rt\ 23 I- 116 TUBERCULOSIS 117 such studies of degeneration of lung tissue Laennec'thus showed that consumption and tubercle were nothing more than parts of the same situation. COMMUNICABILITY OF TUBERCULOSIS. — No one ap- parently believed in the possibility of tuberculosis being a communicable disease until the epoch-making studies of Villemin, who in 1862 demonstrated by carefully con- trolled animal experimentation that tuberculosis could be communicated from one animal to another, thus for the first time refuting the existing theory that tubercu- losis was a hereditary disease. THE TUBERCLE BACILLUS. — The causative agent of tuberculosis was not known until in 1882 Koch of Berlin described the tubercle bacillus. Not until 1884 did he fully describe the nature of this parasite and show that the tubercle bacillus was found in tuberculosis of the lungs; in " white swellings" which some authorities be- lieved to be tuberculosis; in Pott's Disease; in diseases of the hip; and in lupus (tuberculosis of the skin). He showed also that this organism, which was always pres- ent in these various conditions, could be grown arti- ficially in various media in pure culture; that the pure culture would show no parasitic life other than the tubercle bacillus; that when these tubercle bacilli were introduced into animals they reproduced a disease identical in its lesions to the disease known as tubercu- losis; and finally that these same tubercle bacilli could be recovered from the organs of the animal which had been given the disease. How Do THE BACILLI ENTER THE BODY? — As soon as Koch's epoch-making discoveries were made known ii8 SCIENCE REMAKING THE WORLD to the scientific world, numerous observers began to ex- periment in order to learn how the tubercle bacillus entered the body. There were those who believed that it entered the body through the respiratory passages; others who thought that it entered the body through the TUBERCULOSIS DEATH RATE OF U 5 REGISTRATION AREA PULMONARY AND OTHtR FORMS • 300 TO 1921 irvc ku.rw.KJ 10. >»4 digestive tract; others by way of the skin; and a few who still believed that the disease was hereditary and that the tubercle bacilli were transmitted directly from mother to infant. The researches of Cornet and others showed that in experimenting upon animals tuberculosis could readily be induced by permitting them to inhale moist air which was impregnated with tubercle bacilli. For a considerable time nearly all the methods for the TUBERCULOSIS 119 prevention of tuberculosis were based on the assump- tion that tuberculosis was caused by inhaling tubercle bacilli. Later researches, however, showed that experi- mental tuberculosis could also be produced in animals by means of the ingestion of food impregnated with tuberculous material or tubercle bacilli. When these animals were autopsied they showed not only tubercu- losis of the intestinal tract, but also tuberculosis of the lungs. Also tubercles could commonly be found in the lymphatic ducts passing from the intestinal tract to the lymph glands of the lung. Von Behring in 1903 made a great contribution to our knowledge when similar ex- periments performed by him with very young animals showed that when the tubercle bacilli were ingested they might induce tuberculosis of the mesentary nodes or of the bronchial lymph nodes without causing any lesion in the intestinal tract. He stated as a hypothesis that tuberculous infection in man would commonly take place during childhood through the digestive tract and that the tubercle baccili would lie dormant in the bronchial lymph nodes for an indefinite period of time. Skin infection was also proved to be possible though rare. INFLUENCE OF THE BACILLI ON THE BODY. — The effect of the tubercle bacilli on the body, once having entered it, depends upon a number of factors. These factors are the initial number of tubercle bacilli, the virulence of the bacilli, and the capacity of the body to manufacture products which tend to wall off the bacilli or to kill them. If the number of bacilli be relatively small and the resistance of the individual good, the 120 SCIENCE REMAKING THE WORLD bacilli will do little harm. This is true even if they are lodged in a number of places, for a reaction is induced which causes the growth of epithelial and interstitial cells which soon form a globular mass and completely surround the tubercle bacilli. The bacilli may remain alive and virulent but are walled off from the rest of the body. These small pin-head size masses of walled-off bacilli are not always readily detected. They are known as miliary tubercles. If, however, the conditions are favourable for the growth of the tubercle bacilli and they find satisfactory conditions for their nourishment within the body, the tissues adjacent to the bacilli are injured and although new cells are formed, these new cells in turn are killed .and the area of dead tissue enlarges, so that we soon have an ulcerating sore in some part of the body. On the other hand, a series of small tubercles may be near together and may combine into one larger tubercle as big as a pea or larger. The tubercle bacilli encased within the wall or cells may not kill the cells which sur- round them, but may gradually cause the degeneration of these cells so that this larger globular tubercle be- comes a soft granular mass. When these conditions develop, a variety of symptoms occur and the individual is then said to have tuberculosis. In the vast majority of instances, when infection takes place the number of bacilli is limited and the process of walling them off from the rest of the body does not cause any disturbance. If, however, a con- siderable number of tubercles are being formed at the same time, the growth of the tubercle bacilli and the TUBERCULOSIS 121 effort of the body to wall off these bacilli produce a reaction as a result of the dissemination throughout the body of the products of the tubercle bacilli. This re- action is expressed in terms of symptoms which make the individual realize that something is wrong. In a comparatively small number of instances this tubercu- lous process becomes chronic, the tubercle bacilli con- tinue to grow, the infected areas become larger and larger, and more and more of the organ in which they are seated becomes destroyed. More and more symp- toms are produced and the efficiency of the body is reduced by the influence of the poisons distributed throughout the body in the circulating blood and by the destruction of part of some organ of the body. In rare instances a tubercle may grow in the wall at a small vein or in a small artery and eventually rupture into the vein, and the contents of the tubercle with many tuber- cle bacilli are thus discharged into the blood stream. When this takes place there is a rapid dissemination of bacilli throughout the body, causing a marked increase in the number of tubercles growing in the body. In such a case the condition known as miliary tubercu- losis is produced. HEREDITY. — As has been stated, until the time of Villemin the generally accepted theory was that tuber- culosis was hereditary. It is now known that fetal infection may occur but that when such infection oc- curs, the mother is in the advanced stages of tuberculosis and tubercle bacilli are circulating in the blood which passes through the placenta into the fetus. This is a occurrence and in only a few instances have reports 122 SCIENCE REMAKING THE WORLD been made of the presence of tuberculosis in a newly born child. The tubercle bacilli are rarely found in the circulating blood, and individuals or animals which are promptly removed from tuberculous parents do not DEATH RATE FROM TUBERCULOSIS, ALL FORM5 I9IO AND I92O COMPARISON FOR CERTAIN AGE CROUPS necessarily become diseased. It is also known that tuberculosis is extremely rare in foundling asylums and that in thousands of children autopsied during the first year of their life tuberculosis is hardly ever found TUBERCULOSIS 123 unless the child had been constantly exposed to an in- dividual affected with advanced tuberculosis. It has been noted also amongst the thousands of infaHts placed out to board by the municipality of Paris that tuberculosis is rarely responsible for death during the first years of their life. EVIDENCE OF THE PRESENCE OF TUBERCLE BACILLI IN HEALTHY INDIVIDUALS. — Naegeli in 1900 reported that he had autopsied over 500 adults dying of all types of disease and found upon careful examination that tubercle was found in 97 per cent, of these autopsies. Many observations were made in the latter part of the I9th century on the autopsies of children which con- troverted the findings of Naegeli in adults. Loomis in New York in 1890 reported the autopsies of a large number of adults who had died as a result of traumatism and found in practically every instance that tubercles were present although the individual did not have the disease known as tuberculosis. Loomis removed the tubercles from the dead bodies of these healthy adults and injected them into rabbits and this injection almost invariably caused tuberculosis. So that prior to the discovery of tuberculin by Koch, it had been surmised if not generally accepted that the tubercle bacilli were pretty generally present amongst all adults and that it was extremely rare to find any evidence of the presence of tubercle bacilli in infants. TUBERCULIN. — Tuberculin, a product of the tubercle bacilli, was discovered by Koch in 1894 and thought by him to have great curative value. Tuberculin when administered subcutaneously produces local, systemic, 124 SCIENCE REMAKING THE WORLD v and" focal reactions. A local inflammation is produced at the site of injection, a general reaction characterized by headache, backache, and fever, and a renewed or increased activity at the site of injection. This latter can readily be seen in lupus. Tuberculin was advocated by Koch as a curative agent, but it has been proven almost valueless and when not properly administered does more harm than good. Koch announced that the general reaction did not take place except in tubercu- losis, but many observers soon found that healthy in- idividuals reacted when larger doses were given. It was found that sometimes 50 per cent, of adults reacted, /and even 90 per cent, at times, depending on the size of the dose. Its diagnostic value was therefore minim- ized. Calmette and Wolff-Eisner found that tuber- 'culin dropped in the eye would produce a reaction. Moro rubbed it into the skin and finally Pirquet in 1907 found that if a very slight abrasion were made in the skin and a drop of tuberculin placed on the abrasion, a local reaction would take place in tuberculous per- sons, but without systemic or focal reaction. At first this test was thought to be of great diagnostic value, but as in the subcutaneous test it seemed that nearly every one healthy or tuberculous reacted, with the exception of very young children. Here was a phenomenon which was difficult at first to accept; but Naegeli had shown that 97 per cent, of adults autopsied showed an old tuberculous process and many others had shown that tuberculous lesions were rare in infants, but that as the child grew older the lesions were more frequently found. It is evident then that there was a marked difference TUBERCULOSIS 125 between tuberculous infection and tuberculous disease. Almost every child in civilized communities is exposed to tubercle bacilli and infection takes place either through the respiratory or digestive tract, so that by fifteen years of age, nearly every child has become in- fected. It is true that nearly all adults harbour tu- bercle bacilli in their bodies, but only when for some special reason these bacilli begin to grow or when additional large numbers of bacilli enter the body does the individual become affected with the disease tubercu- losis. TUBERCULOSIS IN MAN AND ANIMALS. — The natural habitat of the tubercle bacilli is the bodies of men and domestic animals. In the aboriginal Negro, tubercu- losis is rarely found unless he is brought in contact with civilization. Occasionally tuberculosis is found in wild animals but usually when they have become domesti- :ated. Three special types of tubercle bacilli are known: the human, bovine, and avian. The human strain is most virulent to man, the bovine less virulent and the avian bacilli are a negligible factor in human tuberculosis. We have already seen that tubercle in- fection is almost ubiquitous among civilized people of the human race. This is also true of the bovine races, but in other animals it is far less common. The ba- rilli, however, will live for months outside of the body but are killed by sunlight. The disease tuberculosis, although occurring in but a small proportion of those in- fected, is one of the most serious of diseases. During the past century one seventh of all deaths the result of tuberculosis. During the year 1921 126 SCIENCE REMAKING THE WORLD 100,000 persons died of tuberculosis in the United States and from 86 per cent, to 90 per cent, of them died of pulmonary tuberculosis. Further, we know that for each person dead of tuberculosis, there are at least three seriously ill of tuberculosis and at least seven more who have symptoms from time to time. This DEATH RATE FROM TUBERCULOSIS IN NEW YORK CITY PER EACH 100.000 INHABITANTS, SINCE 1898 100. 236 239 Z37 229 2OT\2R 2B 212 2* 209 I9« KJ7 181 180 173 171 I7J 169 159 164 160 132 109 47 47 43.33 36 34 M 2fl 30 29 29 Z7 29 30 2$ *8 27 27 23 Z4 24 20 n 283 296 280 264 Z43 246 250 240 246 236 227 U4 2JO 210 201 «9 200 ISA 182 IM 184 152 126 means that at least a million persons in the United States will be either seriously ill or have symptoms of tuberculosis this year. A similar situation exists among all civilized races. These enormous numbers of deaths and illnesses occur most frequently during early adult life and chiefly among tvhe wage-earner group. When standards of TUBERCULOSIS 127 living are low or overcrowding or under-nourishment exists, the death rates are higher, and conversely among the wealthier class the amount of disease and death is low. IMMUNITY FROM TUBERCULOSIS. — Practically no one is immune to infection, but many are immune to the disease. The exact reason for this immunity is not known. Immunity is racial, family, or individual. The Jews and the Italians are relatively immune while the Irish and the Negroes have very little immunity. Family immunity exists, for in many families no evidence of tuberculosis may exist for generations. Then some- times one individual in a family may remain well when all other members become diseased even though ap- parently exposed to the same dangers. Individual immunity varies also, for the immunity is lowered by acute illness, pregnancy, childbirth, long hours of laborious work, and constant undernourishment. DANGERS OF INFECTION AND DISEASE. — The dangers are twofold. First, the risk of receiving at one time large quantities of tubercle bacilli from a case of ad- vanced pulmonary tuberculosis or from the milk of a cow with tuberculosis of the udder. Second, having one's resistance lowered as a result of ill health or a poor standard of living. In many instances both factors play a part, as when a healthy woman cares for her tuberculous husband, the family income is lowered, the woman's work becomes more arduous and she is con- stantly exposed to infection. There is no considerable danger, however, from the brief exposure of healthy individuals to those affected with tuberculosis which 128 SCIENCE REMAKING THE WORLD may occur daily in our crowded cities. Nurses, physicians, or employees in hospitals and sanatoria for tuberculosis are not thought to be in any considerable danger. In the latter case the patients are trained in the employment of sanitary precautions and tubercu- losis is more rare in this class of hospital employees than in the same class outside of institutions. Consequently the presence of such an institution in a community is of no danger to its population. Milk from cows not proven to be free from tuberculosis is undoubtedly a source of danger, especially to young children whose intestinal wall will not always prevent the tubercle bacillus from entering the lymphatic system. Proper methods of pasteurization remove this danger. SYMPTOMS OF PULMONARY TUBERCULOSIS. — The symptoms of pulmonary tuberculosis at the onset are cough with or without expectoration, loss of weight and strength, slight rise of temperature, and the spitting of blood. Any one or any group of these symptoms should arouse suspicion, and the patient merits a phys- ical examination and an examination of the sputum, if there is any, for tubercle bacilli. If they are present it is a positive diagnosis. The examinations should be repeated if symptoms persist and an X-ray examination should be made also. The disease may be active, how- ever, and detected by medical examination even when no symptoms exist. Fortunately this condition is re- latively rare. Persistent cough and unexplained fever are danger signals and a pulmonary hemorrhage or hemoptysis is almost positively diagnostic. If the disease progresses, cough and expectoration, fever, TUBERCULOSIS 129 emaciation and night sweats are the prominent symp- toms. Hemorrhages may occur and complications may arise in various parts of the body. NON-PULMONARY TUBERCULOSIS. — If tuberculous disease develops elsewhere than in the lungs, it develops NEW YORK CITY DEATHS FROM TUBERCULOSIS SINCE 1898 _ «» •«" MB trn TMS <*4 a train of symptoms depending primarily on its location. If the meninges be affected, symptoms of meningitis; if the pleura or peritoneum, symptoms of pleurisy or peritonitis; if the intestines, symptoms of inflammation of the bowels; if glands, symptoms of inflammation re- sulting in a cold abscess; if bone or joint, symptoms of osteitis or arthritis. TREATMENT OF TUBERCULOSIS. — Any chronic disease to be successfully treated requires two important fac- 130 SCIENCE REMAKING THE WORLD tors — a skilled physician and a patient with character and an earnest desire to get well, come what may. There is no specific cure for tuberculosis though many cures have been heralded. Reliance must be placed upon rest, nourishment, and fresh air under the guid- ance of the physician. Sanatorium treatment is extremely valuable in training the patient to follow closely rules of conduct as to food, air, and rest, and the more skilled physicians are usually found in sanatoria or in resorts near them. Climate is a relatively unim- portant factor, for recoveries take place in our crowded cities and in all climates. The disease was once sup- posed to be incurable. Not only are most cases cur- able, but thousands of persons who have been cured gladly give this testimony. THE PREVENTION OF TUBERCULOSIS. — Preventive measures are primarily those which will prevent the bacilli from entering a healthy body by killing the bacilli as soon as they leave an infected body. If all bacilli coming from tuberculous individuals in the sputum or other discharges could be destroyed and all milk coming from tuberculous cows could be pasteurized, tubercu- losis would soon disappear. Unfortunately, large masses of people do not know this and many persons have tuberculosis who do not know it, or even after they know it they endanger the lives of their families by care- less habits. It is necessary, therefore, to educate the public in so far as is possible; to provide sanatoria for the care and cure of tuberculosis; to provide hospitals or special pavilions for the isolating of the more dangerous advanced cases; dispensaries to care for ambulatory or TUBERCULOSIS 131 moderately advanced cases, to supervise the chronic milder cases and to ascertain what facilities are avail- able for institutional care; and finally public health or tuberculosis nurses to educate the other members of the patient's family and others to take the precautions necessary to prevent the disease. Other general measures which improve the public health or the individual health are useful. Public health measures which provide pure water, sewage disposal, clean streets, sanitary housing, and measures which prevent other communicable diseases; general measures which improve the individual health by means of education of the care of the body; the Modern Health Crusade which not only teaches children the principles of health, but also trains them to acquire healthy habits; the playground, the summer camp, the fresh-air home, outdoor sports, proper habits of exercise and diet, rest and play and all measures which improve body health help in the prevention of tuberculosis. RESULTS OF PREVENTION. — The death rate in the United States from tuberculosis has fallen from 201 to 99 per 100,000 during the past twenty years, which caused a saving of 100,000 lives in 1921. The value of these lives is almost beyond compute, as is also the cost of caring for such an army of sick persons. Suffering, death, and sorrows have diminished, but there still remains much to be done. WORK STILL TO BE DONE. — More scientific research to determine many unknown factors on infection and immunity and the final perfection of a cure for tubercu- losis which would be as effective as quinine is for malaria, 132 SCIENCE REMAKING THE WORLD or a preventive as effective as vaccination for smallpox. Failing these, there is great need for increased education of the public, more health education for school children, better training for physicians and nurses from the scientific and social aspect. Most persons need not have tuberculosis unless they choose to do so by de- clining to do the things necessary for its prevention. GUIDE TO FURTHER READING "Pulmonary Tuberculosis," by Otis. (Leonard.) 1920. "Early Pulmonary Tuberculosis," by Hawes. (Wood.) 1913. " Rules for Recovery from Pulmonary Tuberculosis," by Brown. (Lea and Febinger, 4th edition, revised and enlarged.) 1923. "Rest and Other Things," by Krause. (Williams & Wilkins.) 1923. "Environment and Resistance in Tuberculosis," by Krause. (Williams & Wilkins.) 1923. "The Causes of Tuberculosis," by Cobbett. (Cambridge Univer- sity Press.) 1917. Bulstrode lecture, Lancet, 1903, vol. 2, page 1199. "Congenital Tuberculosis," by Warthin and Couie. Journal of Infectious Diseases, vol. 1, page 140. "Relation of Human and Bovine Tuberculosis." Report of ?"itish Royal Commission, 1905. "What You Should Know About Tuberculosis." Pamphlet 106, .National Tuberculosis Association. " Sitting and Sleeping in the Open Air." Pamphlet 101, National Tuberculosis Association. LOUIS PASTEUR, AND LENGTHENED HUMAN LIFE BY OTIS W. CALDWELL, PH.D. Teachers College, Columbia University WHEN Louis Pasteur was sixteen years old his father, anxious about his education, decided to send him from the home town of Arbois to Paris. The boy was to have the advantage of instruc- tion in the ficole Normale, a school in which the father thought there would be an exceptionally good oppor- tunity for his boy since the Ecole Normale had been es- tablished to train men for college positions. This was in 1838, when schools were not generally as good in France as they are to-day. The elder Pasteur did not have the privilege of much schooling but had gained a fair education for his time by personal industry and efforts. Like many a father of recent times, or to-day for that matter, Louis' hardworking father decided that poverty should not deprive his son of a good education, and thus planned family sacrifices in the name of the boy's education. That parental sacrifice does not guarantee an education was as true of Louis Pasteur as it has proved to be of many another boy or girl. No sooner did the boy find himself at the school in Paris than an old and honourable malady befell the boy — homesick- ness. It is honourable and eminently respectable to U3 134 SCIENCE REMAKING THE WORLD be homesick, even almost disgraceful not to be so on occasion; but succumbing to this worthy emotional illness is not so respectable. Louis Pasteur's father was a tanner of hides, as had been his grandfather and great-grandfather. His home was near the malodorous tannery yard, and his childhood home street in Dole before his family moved to Arbois, was known as the "street of the tanners." From his birth in 1822 until he was almost sixteen years of age, his life had been more or less associated with the tannery. And now, as a lonesome boy in a distant school, in a great city one hundred leagues from home, he longed so earnestly "for a whiff of the old tannery" that genuine illness would have been welcome if it could have secured his return to his home. Hours were days to the boy, and he soon decided he could stand it no longer. His work was poor, he was miserable, and so wrote to his father. The father, with much depression, went to Paris and took the boy back to his Arbois home. The halo over the home and playground is some- times more easily seen one hundred leagues away than close at hand. It was so with young Pasteur, for the halo evanesced and certain stern realities appeared. He soon announced his readiness to return to Paris, but the wise father replied that the schools of Arbois would suffice for the present. The boy became an outstanding pupil in drawing, so recognized by all. At night he went over all of his day's lessons with his father, not the lessons of the next day, as is so commonly done now- adays to make sure that pupils know their lessons; but the lessons of the preceding morning and afternoon, as LOUIS PASTEUR 135 the father desired to learn those things with which the son was dealing, and Louis became truly his father's teacher. Two years in the schools of Arbois, then two years in the college at Besancon not far from Arbois, brought to Louis recognition as a successful student and as a tutor of his fellows. Then, at twenty years of age, in 1842, he returned to Paris as a student in the Ecole Normale, soon to be widely recognized as a young man of industry, intellectual integrity, and earnest devotion to his studies. In addition to other studies, Pasteur attended lec- tures at the Sorbonne and devoted much time to the study of the structure of crystals. He became widely known and highly respected as a student of chemistry, and on January 15, 1849, began an eight-year period of useful service as professor of chemistry at the University of Strassburg. A characteristic Pasteurism occurred in the early part of his stay at Strassburg. The rector of the University was most cordial to the newly arrived professor of chemistry and took him to his home, where Pasteur was introduced to the rector's wife and daughter. In two weeks Louis addressed a lengthy letter to the rector, serving notice that the elder Pasteur, according to the customs of the times, would soon appear and propose marriage between Louis and the daughter. In this letter Louis informed the rector that, "as to the future, unless my tastes should completely change, I shall give myself up entirely to chemical research." The father came, the proposal was made and duly ac- cepted, the marriage occurred in three months. At the close of 1854 Pasteur left Strassburg for a pro- i36 SCIENCE REMAKING THE WORLD fessorship at the University of Lille, where he served for two years. Then he went back to Paris, which was the central location of his work for the rest of his life. When Pasteur went to Lille he fully expected to con- tinue his studies in chemical and physical problems relative to crystals. The brewers and wine makers about Lille were having great difficulty since they could not be certain to secure the kinds of fermentation speci- fically needed in different cases, in order to produce the different specific results they desired. The wine and beer "went wrong," fermentation could not be con- trolled, and the industry was suffering great financial losses, said to exceed #20,000,000 yearly in certain years. Pasteur was known as a chemist, and as a mani- pulator of the crude microscopes of that day. The manufacturers appealed to him to solve their problems, and he reluctantly agreed to the temporary diversion from his chosen studies, for he saw in this study great possibilities of new knowledge. Through the studies of famous German students, much had recently been learned about the yeasts which produce fermentation and about certain bacteria, but application of these studies had not been made in the brewing industries. There was still extended belief that the living organisms of fermentation came into existence spontaneously (spontaneous generation of life, as it was called), and that such organisms spring into existence in the wine and beer because of "a vital force of nature," and thus injure it. Pasteur, and others even more than Pasteur, proved that if nutritive liquids are sterilized and con- LOUIS PASTEUR 137 stantly kept from contact with air and other unsterile substances, no organisms will develop within this nutri- tive liquid no matter how lung the experiment is con- tinued. There was recently exhibited in the United States (1922), a flask of beef broth which it is claimed, correctly no doubt, that Pasteur prepared over fifty years ago. The beef broth is still fresh-looking and clear, never having had the stopper removed from the glass flask in which the broth has been constantly kept. Small living things, like the larger ones which we readily see, come only from other living things of their own kind. The process of treating wines as recommended by Pasteur, known as pasteurization, has since been applied to milk in all civilized countries. With previously gained facts in mind, Pasteur pro- ceeded to separate single living yeast plants under his microscope, and then to grow pure cultures from these organisms thus separated. He not only found that they grew as pure culture, but that each kind of small organism produced its own peculiar kind of fermenta- tive products in the nutritive liquids. He thus taught the brewers and wine manufacturers how to separate, grow, and use the particular kinds of living microscopic organisms which produce the kinds of wine and beer that they desired. We are not keenly interested in the fact that such dis- coveries taught people how to save the alcoholic in- dustries of France and Germany. What interests us most is that he isolated the microscopic organisms, grew them in pure cultures, and proved that micro- scopic living things, like the larger ones we readily see, 138 SCIENCE REMAKING THE WORLD each produces its own peculiar results as product of its life and growth. We need to recall that when Pasteur was studying fermentation the human race did not know the causes of human diseases. Causes had been suspected, but not proved. What we know to-day as the science of public health did not exist. The bacterial origin of diseases was merely suspected, and the idea generally ridiculed. If a person had been bold enough to assert as true even a small part of what we now know to be true, such a person would have been thought insane or foolish. It was then not uncommon to think that persons who be- came ill had been guilty of some gross wrong-doing, and that illness was sent upon them as punishment for their sins. Or it was sometimes said that the "humours of the body," of which the blood and the bile were two, in some way got into wrong proportions or became de«- ranged and thus caused illness. It is now generally known that most, if not all, common diseases are caused by living microscopic organisms, either bacteria or small animal parasites. Though this knowledge is but a few decades old, it is so common that it is difficult to put ourselves back to the recent date when the human race did not possess this knowledge. It is of such un- told importance that Louis Pasteur lived and accom- plished what he did, that, as we read this chapter, we must imagine ourselves for a time moved back a little more than forty years in the history of man's desire and efforts to have better health. Then, as now, most people wished to live instead of to die, and while living wished to have the best possibk health. Then, as now, LOUIS PASTEUR there were some benighted people who would not do the things necessary to produce good health, even if knowledge of how to do them were available. When Pasteur's yeast and spontaneous generation studies were almost completed, he was urged to go to southern France to try to discover why the silk worms were sick. He tried to decline saying: "I have never touched a silk worm in my life." Why did people urge Pasteur to do this ? Why didn't they call a bacteriolo- gist or a student of insect diseases? At that time there were no bacteriologists because there was no bacteriol- ogy. Of course there were bacteria, but since no one then knew the laws of bacteria, there was no bac- teriology. Likewise there was no science of insect diseases, or science of diseases of men as we now under- stand those terms. For many years the silk industry of France had suf- fered. Often the worms became sick and died, or if they lived, they produced poor cocoons. Poor cocoons, or no cocoons, mean reduction or loss of the desired silk, which means poorer food for the people, poorer education for their children, and all the poorer things which accompany reduction or loss of a fundamental in- dustry. So important was the silk industry in southern France, and so great the anxiety about the health of the silkworms, that one writer says the workers when meet- ing would salute one another by saying: "Good morn- ing! How are the silkworms this morning?" What they desired was good healthy adult silk moths which laid good moth eggs; that these eggs should hatch into worms which might feed and grow healthily upon their 140 SCIENCE REMAKING THE WORLD food, the mulberry leaves; that the full-grown worms might spin good cocoons from which the workers could unravel the desired silk; that enough good cocoons should be left to produce adult moths to continue pro- duction of new supplies of healthy eggs. 1 Pasteur began this study in 1865. He studied the eggs and found within some of them certain small bodies resembling the smallest animal cells. He called these bodies corpuscles, simply meaning "small bodies." He notecf that when eggs which contained the cor- puscles hatched, the worms were sickly and usually died. Using his crude microscope, he separated the eggs which contained no corpuscles and caused them to natch. The worms thus produced seemed to be healthy, and after careful work, Pasteur announced that people 'could produce healthy worms and good cocoons by se- lecting eggs which contained no corpuscles. When this was tried and failed, Pasteur patiently returned to his microscopic studies and found another small organism, a bacterium, and immediately concluded that the silk- worms had two diseases instead of one. One, pebrine, was caused by the animal corpuscles; and the other, flacherie, caused by bacteria. Through long and care- ful experiments he discovered that eggs selected so as to be free from corpuscles and bacteria would produce healthy worms; that such worms when grown upon fresh mulberry leaves would mature and produce good silk cocoons; but that even healthy worms when grown were likely to sicken and die. He thus concluded that the corpuscles and bacteria produce the diseases, and that .diseases from sick wTorms may be transmitted to healthy LOUIS PASTEUR 141 worms by contact with the food in which sick worms have fed. It is not so important that Pasteur taught France how to save her silk industry as it is that he proved that the small organisms produce the diseases; that transmission of the organisms may transmit the Disease; and that prevention of transmission prevents disease. We are not likely to over-estimate the im- portance of these discoveries to modern public and individual health. . Meantime the cattle and sheep industry of France and of other countries was suffering from a disease known as anthrax. So deadly was anthrax to human beings that when once it was clear that a person had the disease, it was regarded almost as a death warrant. Fortunately and for reasons then unknown, the disease did not often attack human beings. Its destruction of cattle and sheep was enormous. Other students had discovered the nature of the bacterium which causes anthrax and had definitely proved the causal relation of the organism. But since no preventive or cure had been discovered, people appealed publicly to Pasteur to attack the problem. No less than 3600 public officers and prominent citizens signed petitions to Pasteur to undertake to find a means of preventing the ravages of this dreaded disease."* He responded and began the study. It is interesting and important to know that the so-called anthrax bacteria cause the disease anthrax; but if they cannot be kept from causing the disease what does the knowledge profit us? If cattle and sheep and men must die, there really isn't large comfort in mere knowledge of what 142 SCIENCE REMAKING THE WORLD caused this wholesale death. That knowledge was es sential for the beginning of Pasteur's study, but was merely the beginning. After many efforts, too many and too intensive to be related in this connection, Pasteur recalled an impor- tant discovery made by the Englishman, Jenner, in J798. Jenner, working in England, noted that persons who milked cows which were ill with cowpox contracted a disease resembling human smallpox, and that there- after such persons would not contract smallpox from human beings ill with that disease. Jenner devised means, now improved and known to everyone, for giving human beings generally the infection or vacci- nation which protects against smallpox. In recalling this situation, Pasteur argued that smallpox was caused by a living organism; that the organism when it lived in cattle did not flourish, and that this organism when introduced from cattle into human beings was not vig- orous enough to produce a bad case of smallpox; that the case produced was bad enough, however, to leave some kind of protection or immunity against an attack from organisms from persons who have a vigorous case of smallpox. This line of thought is most interesting when we recall that we do not yet possess satisfactory evidence as to just what kind of an organism causes smallpox. Meantime Pasteur had been carrying on experiments with chicken cholera. He left cultures of chicken chol- era germs in his laboratory, and went away for a short vacation. Upon his return he found that these old cul- tures would no longer produce chicken cholera when LOUIS PASTEUR 143 some of the cultures were injected into fowls. Most important of all, he found that after the fowls had been treated with these old cultures they would not take chicken cholera even when injected with fresh and viru- lent germs. Therefore partly by chance came the dis- covery of the process of vaccinating poultry against cholera by use of depleted cholera germs or possibly by use of the dead products remaining in old cultures of these germs. Thus Pasteur began his efforts to reduce the vigour of anthrax germs so that perchance they might not pro- duce anthrax of usual destructiveness. Many highly illuminating experiments were performed. Finally, by growing anthrax bacteria in beef broth at high tempera- tures, it was found that they flourished for a time, then slowly died out. By using some of these cultures when the bacteria were much depleted, it was found that sheep could be given mild attacks of anthrax from which they recovered. After their recovery they were given fully active anthrax germs, from which the sheep promptly developed bad cases of anthrax and died. Pasteur then tried a first vaccination of depleted bacteria, and when the sheep had recovered, gave a second mild at- tack by use of bacteria much less depleted than those first used, but far from normal vigour. The sheep and cattle upon which this experiment was tried took suc- cessive mild attacks of anthrax. Thereafter, fully virulent anthrax bacteria failed to produce the disease, and Pasteur announced his triumph in producing pro- gressive vaccination with successful results. So important was this discovery that Pasteur was 144 SCIENCE REMAKING THE WORLD challenged to make a public demonstration of his claims. The Agriculture Society at Melun, France, offered to provide sheep and cattle for the demonstration. Dele- gates were invited and came from many interested organizations and countries. Pasteur penned ten sheep to serve as controls to determine whether anthrax was in the food, air, or water given to them and to the other sheep and cattle. Twenty-five sheep and six cows were to be vaccinated, and twenty-three sheep, two goats, and four cows were not to be vaccinated but were to receive fully virulent anthrax bacteria at the same time as the vaccinated sheep and cattle. On May 5, 1881, the first vaccination was given to the twenty-five sheep and six cows. On May 17, 1881, the second vaccination was given to the same animals. On May 31, 1 88 1, fully virulent anthrax germs were given to all vaccinated sheep and cows, to the four remaining cows, and to the twenty-three sheep and the goats. Pasteur told the delegates to return on June 2. This direction was unnecessary as most of them did not leave, so keenly did they appreciate the momentous impor- tance of what was going on. Many were disbelievers and expected Pasteur's downfall. The results were trium- phant. On the morning of June 2, all of the non- vaccinated sheep and cows and the goats were dead, dying, or severely ill. Not a vaccinated sheep or cow or a control sheep died as a result of the treatment they had received. Since that day the human race has known how to avoid anthrax, if only it will do what is known as good to do. More than this, the idea of successive vaccination was proved, and this has been the founda- LOUIS PASTEUR 145 tion of many subsequent advances in prevention of diseases of several types. Did Pasteur then retire from active labour, one man's gigantic work having been done? Did he remind his co-workers that since 1868 half-paralysis had made his work very difficult? No! Rather he reminded his closest friends that his part-paralysis which he suffered in 1868 enabled him to make more cautious and effective use of those parts of his body not affected by his mal- ady— a malady for which the answer is not yet at hand. Instead he turned now to his last and most spectacular achievement. For many years the sympathies of this great founder of the science of bacteriology had been sorely tried because of the ravages of the awful disease rabies or hydrophobia. It is doubtless true that the cry of "mad dog" has created human panic since the times of primitive men. No sane person who has wit- nessed death from hydrophobia will willingly do so a second time, unless he is needed in ministrations of assistance or mercy. For years Pasteur had studied the dreaded disease and performed experiments with rabbits and other animals in efforts to locate the causal organism and to find a preventive or cure. It almost belittles this gigantic task to go directly to results, omitting description of many fruitless efforts, false hopes roused in the man whose heart as well as mind was now devoted to his supreme task. However, one day, after many failures to locate any guiding arrow, Pasteur used for inoculation in a rabbit a piece of old and dry spinal-cord tissue previously taken from a rabbit that had died of rabies. He had previously oftentimes 146 SCIENCE REMAKING THE WORLD transmitted the disease by use of nerve tissue, but the diseases thus produced were violent and death- producing. This time, however, the desiccated nerve tissue produced a mild attack from which the rabbit recovered. Following this lead, a series of less and less dry nerve tissues were used to produce a cumulative series of mild attacks, after which the bite of a rabid animal failed to produce hydrophobia. At this juncture one of the most striking events of all science occurred. Frau Meister, of Alsace, had a boy, Joseph, who two days before had been bitten by a rabid dog. Such an attack as that shown by the four- teen bites upon the unfortunate boy had been previously regarded as meaning almost certain death. The mother had heard of Pasteur, and at once started to Paris with her boy. The treatment had not been given to any human being; it was not known whether results would be similar to those obtained in lower animals; it was not known what series or gradation of treatments would be necessary for human beings; it had been proved that the treatment could be applied to animals after a rabid bite, and that protection could be secured. Frau Meister was obdurately insistent. Pasteur's advisers intimated that the boy's death would be upon Pasteur if he refused to treat him and the mother absolved him from responsibility if the treatment were given. Against advice from his friends, Pasteur began the experiment upon the boy, shortening the periods between treat- ments in efforts to secure cumulative protective results. The ignorant but beautiful confidence of the mother and boy permitted them to sleep and rest between^ LOUIS PASTEUR 147 treatments; but the highly intelligent understanding and tremendous responsibility and hope of Pasteur made sleep and rest almost impossible for him until the crisis had passed, and he felt sure that the boy's life had been saved. Soon Pasteur institutes appeared in available centres throughout the civilized world, and to-day it is very rarely that a human being need die from hydrophobia. Superstitious and ignorant fear of hydrophobia has given place to the intelligent guidance of modern science. On Pasteur's seventieth birthday (1892, three years before his death) delegates from the scientific societies and public bodies of the civilized world met in France, in the great theatre room of the Sorbonne. The band of the Republican Guard of France played the triumphal march. The President of the Republic was the escort as down the aisle came one of the greatest heroes and benefactors in human history. Gounod directed a choir which sang his Ave Maria. Coquelin recited verses written by him especially for this occasion. The Minister of Public Instruction among other things said: Who can now say how much human life owes to you and how much more it will owe you in the future? The day will come when an- other Lucretius will sing, in a new poem on Nature, the immortal Master whose genius engendered such benefits. Joseph Lister, when called upon said: Your researches upon fermentations have thrown a powerful light which has illuminated the baleful darkness of surgery and has changed the treatment of wounds from an uncertain and too often i48 SCIENCE REMAKING THE WORLD disastrous empirical affair into a sure beneficent scientific art. Thanks to you, surgery has undergone a complete revolution which has robbed it of its terrors, and has enlarged almost without limit its efficacious power. Medicine owes not less than surgery to your profound and philosophical studies. You have lifted the veil which had covered infectious diseases during the centuries; you have dis* covered and demonstrated their microbial nature. Thanks to your initiative and, in many cases, to your own special work, there are already a large number of these pernicious maladies of which we now know the causes. Then Pasteur rose and spoke quietly and feelingly of his hope that science would save men from their bodily ills; that men will be more useful when free from dis- ease. Then turning to the delegates he said: And you, delegates from other nations, bring me the deepest joy that can be felt by a man whose invincible belief is that Science and Peace will triumph over Ignorance and War, that nations will unite, not to destroy, but to build, and that the future will belong to those who will have done most for suffering humanity. The foundations of the science which may remove from man all his bodily ills if only he will turn his mind to them long enough, with sufficient patience and un- selfishness— that is the achievement of Louis Pasteur. Human life is now much lengthened because of the work of Pasteur, by the few others of hi s time, and by the many others since who have been stimulated and whose work has been made possible by him. Those who know and do what modern health science teaches are the ones whose lives are lengthened. It is they who are of most worth to the world. A man at forty has just learned how to work. To add ten or fifteen or twenty years to his life saves to the world a man who is equipped and ready. His added years may double his service to the LOUIS PASTEUR 149 world. Surely in an age when great warriors are still extolled, it is supremely important for our young people to appreciate that true heroes help men to live and serve rather than teach them to vanquish and destroy their fellows. GUIDE TO FURTHER READING "The Life of Pasteur," by R. Vallery Radot. Translated from the French by Mr. R. L. Devonshire. Doubleday, Page & Co., Garden City, N. Y. 484 pages, 1908. "The Influence of Pasteur on Medicinal Science." Dodd, Mead & Company, New York. 77 pages, 1904. " Pasteur, The History of a Mind," by Duclaux. Translated by Erwin F. Smith. W. B. Saunders Company, Philadelphia. 363 pages, 19*0. INTERNATIONAL PUBLIC HEALTH BY GEORGE E. VINCENT, PH.D. President of the Rockefeller Foundation, New York City IF THE hygienic control of the world were put in the hands of some superman with scientific knowledge and authoritative powers it is possible to imagine the way in which he would organize his forces and carry out his task. First of all he would not rest content with the scientific resources in his possession, but would provide for continuous investigation in order to re- examine constantly the knowledge already acquired and to add new information. He would fit up well- equipped and competently manned centres for investi- gation. These institutions he would place in strategic positions throughout the world in such a way as to bring the widest variety of diseases under constant scrutiny. He would further see to it that the staffs of these research centres were in constant communication so that duplication of effort would be avoided and the results secured in one place put quickly at the disposal of workers in all the other institutions. In this way he would organize medical research as a world activity, constantly recruiting his groups of investigators and producing steadily new knowledge about the nature, cure, and especially the prevention of the maladies which afflict mankind. 150 INTERNATIONAL PUBLIC HEALTH 151 In the second place, this hygienic force would effect an administrative health organization throughout the World. Each country would be subdivided into sani- tary districts, while the nations themselves would be brought into a unified administrative system under central control. Thus stationed throughout the world would be health officers with their technical experts and subordinates all organized into a hierarchy under single authoritative control. Under such a military regime sanitation, control of epidemics, regulation of individual conduct in the interests of health would be in force with all the efficiency which characterized the success of pre- ventive measures in Cuba and the Panama Canal Zone. In the third place, through such an organization as toas been described, there would be centralization of vital statistics — accurate and trustworthy conclusions based upon the reports of competent diagnosticians per- forming their duties in an objective way uninfluenced by economic and social considerations. These statistics constantly gathered and interpreted by experts, would guide the organization and conduct of health campaigns in various parts of the world to meet situations as they were revealed by the statistical data. The appearance of an epidemic would be instantly reported to head- quarters and orders would issue at once to apply meas- ures which would insure the prompt control of the threatened outbreak. Outposts and barriers against epidemics would be established and held in readiness for emergencies. Gradually the foci of diseases would be circumscribed until finally these sources of danger would be eliminated. 1 52 SCIENCE REMAKING THE WORLD In the fourth place, the guardian of the world's health would not rest content with the negative control of disease. He would regard sanitation and epidemiology as only the first steps toward a positive campaign to be carried out through control of the diet, housing, exer- cise, and recreation of the world's population. This benevolent autocrat would see to it that children'were well born and nourished and from their earliest days trained to hygienic habits. In this way he would, through the perfect obedience of millions to the dic- tation of wisdom and benevolence, produce a vigorous and healthy race. Of course, as fundamental to this entire programme the commanding officer would establish medical schools and training centres in which the officers and privates of his army of hygiene would be recruited and trained for their important tasks. Under his guidance medical schools would transfer their chief interest from the cure to the prevention of diseases. The stress would be laid upon early diagnosis and upon preventive treat- ment, upon frequent medical examinations, upon sound habits of living, upon the importance of mental serenity and a stimulating social life. From such schools of medicine and hygiene would go out men and women apostles of the doctrine of prevention determined to keep people well and regarding the occurrence of disease among those under their charge as a serious reflection upon the vigilance and resourcefulness of the members of the profession. The description of an arbitrary control of this kind is in itself sufficient to show how impossible and in- INTERNATIONAL PUBLIC HEALTH 153 tolerable such a regime would be. Local autonomy, nationalistic feeling, the absence of supermen, and human nature's resentment of control imposed from without are a few of the many obstacles which would make it utterly impossible to bring about the hygienic solidarity of the world. But the outlining of an imagin- ary unified system of control at least serves as a back- ground against which to observe influences which have been going on for a long time in the world, but which of late have gained greatly in definiteness of organization. In some sense, every one of the things which have been suggested as a part of an imaginary world organization is being to a degree accomplished. Thus there are more than 445 medical schools scat- tered throughout the world. They represent the in- fluence of three systems of medicine: the British, the Latin, and the German. These systems have been dis- tributed in accordance with well-organized principles of national influence. The British system has prestige throughout the Empire, subject to modification espe- cially in Canada. French medicine prevails in the Latin countries of Europe and in Central and South America; while the German plan is largely followed in Scandi- navia, Austria, eastern Europe, in the Balkan regions, and in Japan. In the United States a combination of British and German methods has been gradually devel- oped with certain features which are not found in either of the two European systems. The three national types are yielding to internal influences which may be counted upon to produce, not uniformity, but a more cosmo- politan ideal than at present exists anywhere in the 154 SCIENCE REMAKING THE WORLD world. In short, forces of intercourse and cooperation are approximating a world system more successfully than anything but the control by a superman could bring about. Moreover, institutes for medical research are found in many parts of the world. Of these the best known are the Pasteur Institute of Paris, the Rockefeller Institute of New York, the London and Liverpool Schools of Tropical Medicine, the Hongkong School of Tropical Medicine. Many other centres exist throughout the world. These centres, through publications, migra- tions, and international congresses are kept in close com- munication so that knowledge of each other's work is quickly disseminated. In a very true sense there is an informal and effective world organization for prosecu- tion of medical research. Many of the medical schools are an integral part of this system, making impor- tant contributions to what is a genuine international product. In the collection of vital statistics definite prog* ress toward world organization has been made. Through the Office International cTHygiene in Paris, forty nations are regularly exchanging information with respect to vital statistics. Uniform methods of reporting deaths have been agreed upon and are to a considerable degree being successfully carried out. The areas from which trustworthy and acceptable re- ports aretnade in various countries are being gradually extended. It is true that only a beginning has been made but these beginnings have sketched a programme of international cooperation in the gathering and dis- INTERNATIONAL PUBLIC HEALTH 155 tribution of vital statistics which will inevitably be steadily elaborated during succeeding decades. Growth of health organizations in different countries is constantly recorded. The leading nations of the world are giving increasing attention to health adminis- tration; administrative areas are being organized and trained sanitarians put in charge. Not only is this national organization going forward, but the nations are drawing closer together in their cooperation for world health. The first European conference to con- sider health problems was held in 1851. Twelve nations were represented. Concerted measures against cholera, plague, and yellow fever were adopted. Thereafter at intervals of a few years other congresses were called to insure better team-work in conformity with rapidly ad- vancing knowledge of preventive medicine. In 1902 an International Sanitary Bureau was established in Washington by the Pan-American Union. Finally, in 1908, a permanent International Office of Hygiene, which has already been mentioned, was established in Paris. The most significant development in this world movement is the recent creation under the League of Nations of a Health Organization which has the direct support of fifty-two nations and the sympathetic co- operation of the United States. The programme of the League's Health Organization includes the gather- ing of vital statistics, prompt notification of epidemics, a standardizing of vaccines and sera, international con- ferences and exchanges of health officers, securing of better health conditions for sailors on shipboard and in 156 SCIENCE REMAKING THE WORLD ports, cooperation with League mandatories, with the Commission on Opium, and with the Labour Office. The fact that great epidemic diseases disregard na- tional boundaries forces upon nations the adoption of cooperative measures against the ravages of these diseases. The first congress in 1851 was called to con- sider ways of dealing with cholera, plague, and yellow fever. The most striking illustration of national cooperation was afforded in 1920 and 1921 by the special commission against typhus in eastern Europe. This campaign was organized under the auspices of the League of Nations and had the direct financial support of fourteen governments. A sanitary barrier was erected in eastern Europe and the march of the disease was halted. There is every reason to expect that co- operation of this sort will become more frequent and that diseases which heretofore have flourished because they encountered only unorganized resistance will now face the united front of a world sanitary army. After public-health officers have done all that they can in the way of sanitation and control of contagious diseases, there remains a majority of diseases with which only the individual can deal. A large part of the prob- lem of public health resolves itself into the question of personal hygiene. Only by changing the health habits of millions can the level of national and world efficiency be raised. In attempting this task certain traits of human nature must be reckoned with. All the re- sources of modern education, publicity, and suggestion must be employed. Especially must the habits of children be formed while they are still in a plastic stage. INTERNATIONAL PUBLIC HEALTH Thus attempts in popular education in personal hygiene are being made in many countries and by various methods. The movement is still in the stage of experi- ment and demonstration. There are some signs of definite accomplishment in this field, but much re- mains to be done in the way of testing the material and methods of instruction before the campaign can be pushed with complete conviction and hope of perma- nent success. But this is inevitable unless control from without is to be substituted for mere self-direction. No one advocates the course of compulsion except with respect to well-established conditions of contagious dis- ease which call for the exercise of the police power of the community in the interests of all. The essential task of training health officers and the various technical experts who form the staff of a modern health organization is being put upon a professional basis. The School of Hygiene and Public Health of Johns Hopkins University, the new School of Public Health of Harvard University, the School for Nurses of Yale University, the training centres at the University of Toronto and at London, Ontario, the new School of Hygiene which is being established in London under the auspices of the British Government, the Institutes of Hygiene at Prague and Warsaw, and many other in- stitutions of a similar sort are equipped to give a thorough professional training, both in the fundamental sciences which underlie modern hygiene and in the prac- tical application of scientific knowledge to the problems of control and administration in the field. Through a system of interchange of health officers being carried 158 SCIENCE REMAKING THE WORLD on by the Health Organization of the League of Nations, a spirit of international cooperation is being created in this individual and personal way; the knowledge of health procedures in one country is being put at the disposal of other nations. The direct cooperation of governments is having an important bearing upon the growth of international hygiene. The leading governments furnish health officers in the ports of other countries so that valuable means of contact and cooperation are established. What amounts to the appointment of attaches of hygiene is being brought about so that it is possible to look forward to a time in the early future when every country will have its sanitary representatives in other lands. Such a system cannot fail to increase in many ways the effectiveness of organization and activity in behalf of world health. Non-governmental health agencies are playing a significant part in the new hygienic movement. The international Red Cross has for many years concerned itself with the health conditions of prisoners of war. With the organization of the League of Red Cross Societies in 1919, a new international voluntary agency was set up. A programme of this society includes as an important feature the promotion of public health measures in the different countries where the Red Cross Society has been established. The Rockefeller Foundation, through its subsidiaries, the International Health Board, the China Medical Board, and the Divi- sion of Medical Education, is carrying on work which, during recent years, has included items of cooperation INTERNATIONAL PUBLIC HEALTH 159 and service in sixty of the governmental areas of the world. It has demonstrated on a large scale the possi- bilities of the control of hookworm disease and the use of such control measures as a means of educating whole populations in the matter of public health work. The International Health Board of the Foundation has also conducted a successful campaign which aims at the complete eradication of yellow fever. This has called for the cooperation of Mexico, Central America, and several South American countries. The outcome is a striking proof of what can be accomplished when nations work together with complete confidence and good-will. Thus as we try to get a picture of what is going on to- day in the world in the interests of the health of all the nations, we see that there is something like an approxi- mation to the ideal system which a superman might conceivably try to set up. As compared with what re- mains to be accomplished, only an insignificant start has been made, but looked at from the standpoint of a century ago, really striking progress has already been achieved. In the last half century the scientific re- sources of modern medicine have been enormously enriched. The causes of a great number of devastating diseases have been discovered; the methods of con- trolling them have been worked out; medical education has been put upon a higher level; a beginning has been made in the training of expert sanitarians and an entire hygienic personnel. Organization of health administra- tion has been greatly increased in efficiency. The death rates in all the leading countries of the world have fallen 160 SCIENCE REMAKING THE WORLD in a most gratifying fashion. Beginnings have been made in the education of the public in the laws of per- sonal hygiene. International understandings and good- will have been promoted. He would be hopeful indeed who should at the present time see anything like a millennium of human brotherhood; but at any rate it is obvious that the tendencies now to be seen in the world toward cooperation for health cannot fail to draw scientific men everywhere into closer comradeship. So much is clear gain. There is reason to hope that for a time at least the resources of science will be turned from the destruction of human life to the healing of the nations. GUIDE TO FURTHER READING American Public Health Association: "Half Century of Public Health; Jubilee Historical Volume," edited by Mazyck P. Ravwiel. N. Y. Auth., 1921, 461 pages. "China and Modern Medicine. A Study in Medical Missionary Development," by Harold Balme. London, 1921, 224 pages. "Progress of Public Health Work," by Dr. J. H. Beard. 152 p. Reprint from Scient. Month., N. Y., Feb., 1922. "International Organization and Public Health," by G. S. Buchanan. Lancet, Feb. 26, 1921, vol. I, pages 415-520. "The International Mind in Medicine," by Kendall Emerson. Boston Med. and Surgical Jour., June 15, 1922, pages 795-799. "Medical Education in the United States and Canada," by A. Flexner. Carnegie Foundation for the Advancement of Teach- ing. Bull. No. 4, 1910. 346 pages. "Medical Education in Europe." Carnegie Foundation for the Advancement of Teaching. Bull. No. 6, 1912. 357 pages. "The New Public Health," by Dr. H. W. Hill. (Macmillan, N. Y.) 1918. 206 pages. "The Future of Medicine," by Sir James Mackenzie. (Henry Frowdc, Hodder and Stoughton, London.) 1919. 238 pages. INTERNATIONAL PUBLIC HEALTH 161 "The New Chivalry — Health." Southern Sociological Congress, Houston, Texas. May 8-n, 1916, 555 pages. "Medical Research and Education," by Drs. Richard M. Pearce, Wm. H. Welch and others. Edited by J. McKeen Cattell. (The Science Press, N. Y.) 1913. 536 pages. (Science and Education, vol. 2.) "The Health Officer," by Frank Overton and Willard J. Denno. (W. B. Saunders Co.) 1919. 512 pages. The Red Cross and International Public Health. League of Red Cross Societies, Second Meeting of the General Council, Geneva, March 28-31, 1922, by Rocco Santoliquido. Documents, vol. 2, pages 115-125. The Worlds Health. A monthly review published by the League of Red Cross Societies. 7 Rue Quentin Rouchart, Paris VIII, France. EDUCATIONAL VALUE OF MODERN BOTANICAL GARDENS BY GEORGE T. MOORE, PH. D. Director of the Missouri Botanical Garden, St. Louis, Mo. THE cultivation of plants for their healing quali- ties by the monks of the middle ages appears tc have been the beginning of the modern botanical garden, although these medieval gardens doubtless took their origin from others of greater antiquity. A most ingenious theory concerning the origin of botanical gardens was put forward by a Frenchman who claimed that during the i6th century designers of embroidery and lace in France sought inspiration from blooming plants. To meet this demand an enter- prising horticulturist opened a garden with conserva- tories in which he cultivated many strange and little- known varieties. Later this garden became crown property and medical students were admitted on condi- tion that they would not interfere with the designers of textiles and laces. Although the aesthetic study of plants must have appealed to those who visited public gardens, and even at the present day designers and makers of artificial flowers get many ideas from study- ing nature, it seems quite certain that botanical gardens were primarily created for the students of maUria medica. 162 MODERN BOTANICAL GARDENS 163 The educational value of a botanical garden did not develop much, if at all, prior to the middle of the 1 7th century, when those at Bologna, Montpelier, Leyden, Pans, and Upsala became more or less note- worthy as aids to scientific teaching. The taste for ornamental and decorative plants had meanwhile been slowly growing and persons of wealth and influ- ence, desiring to cultivate rare and unusual species, began to employ men skilled in botanical knowledge to take charge of their gardens. The world was searched for new and rare plants which were brought back for cultivation in the botanical gardens of Europe, and many handsomely illustrated volumes describing these plants were pubHshed by the rich patrons of botany. These older gardens were essentially private institu- tions, but gradually a few of the existing establishments and a number of new ones were opened more or less to the public. Modern botanical gardens, therefore, have a number of functions which have not appeared simultaneously but have been a matter of gradual development. Be- ginning with the utilitarian idea, there have been added to this the aesthetic, the scientific, and the educational. Naturally these elements have been given different de- grees of prominence depending upon local conditions; but whether a garden be essentially scientific or mainly utilitarian, or combine all of the essential functions of a garden, it is clear that the educational features are receiving more and more emphasis. Formerly a public garden was a mere museum of living plants; at best a place for recreation and pleasure. Nowadays the at- 164 SCIENCE REMAKING THE WORLD tempt is to have collections which, while appealing to the sense of the beautiful, will give definite information and instruction to the amateur as well as to the specialist. The modern botanical garden fails to serve the com- munity as it should if the school pupil as well as the advanced student is unable to learn much from it. Mod- ern educators who are seeking to find improved methods of teaching are beginning to recognize the fact that gardens furnish some most important and unique op- portunities for imparting knowledge. Formerly books and travel were the chief sources of information to the general public; in these days of the phonograph, the radio, and the moving picture, visual education is taking a larger and larger place. Exhibits of plants native to countries being studied in geography may give a better, idea of conditions in that country than anything short of an actual visit could accomplish. The growing of tropical fruits, spice and perfume plants, rice, cotton, sugar cane, coffee, tobacco, peanuts, and other economic plants, particularly if their peculiarities are pointed out by one familiar with their various characteristics, forms a most helpful adjunct to modern educational practices. Nowhere can fundamental facts concerning heredity, selection, and breeding be so well demon- strated as in a garden; and an insight into physiology, morphology, and pathology may be easily gained when presented through the life of a plant. Most children are interested in gardens of one sort or another and through their desire to learn what to grow and how to grow it, as well as the kind of care which must be exer- cised in order to make a success, many important bits MODERN BOTANICAL GARDENS 165 of real knowledge, as well as much general information may be imparted. For this reason a botanical garden as an educational institution may be a much more helpful feature in a community than a zoological park or a museum, since it comes so close to everyday life. It is impossible to treat in detail the various kinds of exhibits and demonstrations prepared to impart knowl- edge to young persons. The ease with which this may be done coupled with its recreational and pleasure- giving qualities, makes it desirable for many communi- ties to include in their educational systems a botanical garden of some kind. Not only should the rare "vegetable curiosities," consisting of a sort of botanical circus, be featured, but common things such as wild flowers, weeds, and farm crops must also be instruc- tively displayed. Accurate labels giving the most im- portan* information about plants are a necessity, and by using different colours to indicate the country from which plants come or the uses to which they are put, definite facts and geographic interpretations are ab- sorbed almost unconsciously. When to the educational function is added the great humanizing power of a gar- den, and the recreational service which it is able to ren- der to the business man, the student and the plant lover, it becomes clear why so many thousands of citizens regularly visit gardens in cities which possess them. GUIDE TO FURTHER READING "Botanical Gardens," by N. L. Britton. Bull. Ton. Bot. CL 1896- 166 SCIENCE REMAKING THE WORLD "History and Functions of Botanical Gardens," by Arthur W. Hill. Ann. Mo. Dot. Card. 2:185-223. 1915. "The Missouri Botanical Garden," by W. Trelease. Pop. Sci. Monthly , 62:193-221. 1903. Various articles relating to specific problems in botanical gardens, by George T. Moore, and others. Missouri Botanical Garden Bulletin, 1913-1923. THE MEANING OF EVOLUTION BY JOHN M. COULTER, PH.D. Professor of Botany, University of Chicago THE meaning of evolution is probably more mis- understood than any doctrine of science. The reason for it is that it has been discussed very freely by those who are not informed, and in this way much misinformation has been propagated. The evolu- tion of the material world, called inorganic evolution, aroused wonder but not apprehension; but when or- ganic evolution came into prominence hostility was aroused, because such evolution seemed to involve man. •»* O* S k,.| &JfM k, wj =1 lia 3*0 - i.s 2S6 CHEMISTRY AND FOOD 257 tural Experiment Station and Professor Lafayette B. Mendel of Yale are the leaders in this field of science and their successful correlation of the chemical differ- ences among proteins with their nutritive functions and efficiencies is one of the great achievements of modern science. Only a hint of it can be given here. When only one protein was fed at a time, along with mixtures of other foodstuffs known to be adequate to all other nutritive requirements, it was found that some proteins are adequate to support normal growth, others support maintenance but little if any growth, while still others always fail even to permit the animal to maintain his weight. A photograph of a rat whose growth had been practically suspended by feeding with a diet good in all other respects but containing gliadin as sole pro- tein is shown in Figure 6 along with photographs, taken at the same focal distance, of normal rats, one of the same age, and another of the same weight, as the rat which had been thus stunted. At first thought, therefore, it may seem surprising that the Inter-Allied Scientific Food Commission while setting standards for food needs in terms of calories declared it unnecessary to set standards for protein on the ground that a food supply of any ordinary character and sufficiently abundant to meet the calorie (energy) requirement can be trusted to furnish adequate protein without special planning. The justification for this view is found in two facts: (i) the quantities of protein actually required for healthy nutrition have been found by much careful research to be considerably smaller than formerly supposed; (2) the differences in nutritive 258 SCIENCE REMAKING THE WORLD efficiency shown by certain individual proteins taken singly do not imply any great danger that the daily food will furnish inefficient protein, because the articles of food which we actually use contain many kinds of pro- tein and these different proteins supplement each other. To explain this fully would require too long a discussion of the individual amino acids of which the proteins are composed. THE MINERAL ELEMENTS AND VITAMINS OF FOODS. — Besides the five chemical elements of which simple pn> teins are composed, about a dozen more are now known to be essential to human nutrition; and besides the chemically known organic foodstuffs at least three other organic substances, vitamins A, B, and C, are also nec- essary. Space does not permit the discussion here of even the more important of our recent advances in the study of the mineral elements of food, and the vitamins need not be further discussed in this chapter since they are treated elsewhere in this volume by Doctor Eddy. It must, however, be emphasized that the recently developed knowledge of the nutritive importance of the mineral elements and vitamins and of the very un- even distribution of these dietary essentials among the different articles and types of foods has greatly clarified our ideas of food values. For progress in this line of study we are greatly indebted to McCollum and Sim- monds, formerly of the University of Wisconsin and now of the Johns Hopkins University. It was for- merly customary to speak as though dietaries could be "balanced" by a consideration of protein, fat, and car- bohydrate, whereas we now see clearly that the mineral CHEMISTRY AND FOOD 259 elements and vitamins are at least equally important in this connection. Taking account of energy values, protein content, mineral elements, and vitamins, we now group the chief articles and types of food according to their outstanding nutritional characteristics as follows: 1. Grain products — economical sources of energy and protein but not satisfactory in their mineral and vitamin content. 2. Sugars and fats — chiefly important from the nutri- tional standpoint as supplementary sources of energy, although some fats are also important as sources of the fat-soluble vitamin. 3. Meats, including fish and poultry — rich in protein or fat or both, but showing, in general, the same mineral and vitamin deficiencies as do the grains. 4. Fruits and vegetables — varying greatly in their protein and energy values but very important as sources of mineral elements and vitamins. 5. Milk — important as source of energy, protein, mineral elements, and vitamins; the most efficient of all foods in making good the deficiencies of the grains and in ensuring the all-round adequacy of the diet. (See Fig. 6.) Fruits, vegetables, and milk are now seen to have much higher food values than were hitherto known, be- cause they serve (as meats, sweets, and most fats do not) to make good the mineral and vitamin deficiencies of the breadstuff's and other grain products. What we now call the newer knowledge of nutrition has been acquired within much less than a generation 26o SCIENCE REMAKING THE WORLD and as yet its practical application has but barely begun. The economic and hygienic benefits which we may rea- sonably anticipate are incalculable. We must remem- ber that the food crops produced by a country are not determined by nature (though writers often seem to imply this) but by the relative demands for the different things which any given farm can produce. The farmer in the long run will employ his land and labour and dis- pose of his crops in whatever way he finds most profit- able and this in turn will depend upon what the con- sumer demands in the market and the relative prices which he (or she) is willing to pay. As fast as consum- ers come to understand that fruits and vegetables and milk are worth more and that meats and sweets are* worth less than has been hitherto supposed, and show this knowledge by shifting the emphasis of their de- mands from meats and sweets to fruits, vegetables, and milk, just so fast will more fruits, vegetables, and milk be produced because they will thus become the crops that pay the farmer best. For instance, when a normal American corn crop has been harvested and all the demands of human consump- tion, of industry, of seed for the next crop, and of feed for the farmers* draft animals have been met, there re- main in the hands of the farmers of the United States over a billion bushels of grain to be turned into extra meat or into extra milk according to which "the mar- ket," that is, the consumer, makes it more profitable for the farmer to produce. Increase in the milk supply need not be entirely at the expense of a decreased meat production, but even if this were true the production of CHEMISTRY AND FOOD 261 milk could be doubled by decreasing the meat supply only one third. Two thirds of our present meat supply would give us a larger per-capita meat consumption than any European country, even Great Britain, has ever enjoyed in modern times — in all probability quite as much as is good for us; while to double the milk supply of the United States would undoubtedly mean a tremendous gain in the well-being of the people. Even if our present milk supply be regarded as ade- quate, we now have evidence that a more liberal supply would be better. ADEQUATE VERSUS OPTIMUM FOOD SUPPLY. — The space assigned for this paper being nearly exhausted, let us conclude it with a brief account of a current in- vestigation demonstrating the fact that through our present knowledge of food chemistry, a food supply al- ready adequate may still be capable of improvement with corresponding gain in health and vigour. In developing and applying the newer knowledge of food chemistry in our work at Columbia University, we have not been satisfied to stop with adequacy of nutri- tion. We have sought to find and to show how a food supply which is already adequate may be made still better so that it will support a higher degree of health. The Century Dictionary defines health as: "Sound- ness of body; that condition of a living organism and of its various parts and functions which conduces to efficient and prolonged life. . . . Health implies also, physiologically, the ability to produce offspring fitted to live long and perform efficiently the ordinary functions of their species." 262 SCIENCE REMAKING THE WORLD We are somewhat accustomed to quantitative ratings of soundness and efficiency and much more so to data of growth rates, birth rates, and statistics of duration of life. In human experience so many factors may enter to influence health in the course of a lifetime that it is hard to separate and measure the effects of food alone. But this can be done with laboratory animals of rapid growth and early maturity like the rat, and in such ex- periments it is possible to determine under conditions uniform in all other respects the influence of food upon the various factors of health comprised in the definition just quoted. Among the recent findings of nutrition experiments carried through successive generations of such labora- tory animals the results of which are, I believe, directly and fully applicable to the problem of the attainment of the highest degree of human health, is the fact that starting with a diet already adequate we may by im- provement of the diet induce a higher degree of health and vigour. This has been rather strikingly shown in experiments with rats in which different families from the same stock have been kept for successive genera- tions upon two uniform food supplies : the first diet adequate as shown by the fact that it has supported healthy growth, development, and reproduction in some families for no less than six generations; the second diet differing from the first merely in that it contains a higher proportion of milk. These experi- ments are still in progress but certain results are already clear. Among the evidences of a higher degree of health CHEMISTRY AND FOOD 263 which we find to result from increasing the proportion of milk in a diet already adequate are the following: 1. More rapid growth. 2. More efficient growth, i. e. a greater gain in weight for each 1000 calories of food consumed. 3. Somewhat larger average size at all ages, though the difference in size is not striking and probably not of great importance. 4. Greater vigour as indicated by earlier maturity, larger capacity for reproduction, and greater success in rearing the young. 5. The period of full vigour was prolonged and the proportion of families dying without issue was greatly reduced. 6. The weight of the mother was better maintained while suckling her young and the young grew and developed better during the suckling period. 7. Both infant mortality and the death rate after infancy were reduced, and this notwithstanding the fact that the females had borne and suckled more young. There is no reason to doubt that all these findings, as thus stated in qualitative terms, will apply equally in human experience and that a higher degree of health will follow an improvement in the dietary of the in- dividual or in the food supply of the community, such as an increase in the proportion of milk, even where the original dietary was already adequate according to all current standards. 264 SCIENCE REMAKING THE WORLD This does not mean, as the sensationally minded would have it, that by the use of a "super-diet" we can produce a "super-race." It does mean that by the right use of our present knowledge and of our food supplies we can in future bring to a much larger percentage of our peonle that full measure of health and efficiency which only the more fortunate now enjoy. May not such results of scientific investigation func- tion somewhere in the curriculum of every school? GUIDE TO FURTHER READING "Economics of the Household", by B.R. Andrews. (Macmillan, New York.) 1923. "The Nutrition of Man," by R. H. Chittenden. (Stokes, New York.) 1907. "The Science of Nutrition," by G. Lusk. New Third Edition. (Saunders, Philadelphia.) 1920. "The Cost of Living," by E. H. Richards. Third Edition. (Wiley, New York.) 1905. •" Feeding the Family," by M. S. Rose. (Macmillan, New York.) 1916. '"Laboratory Handbook for Dietetics," by M. S. Rose. Second Edition. (Macmillan, New York.) 1921. "Chemistry of Food and Nutrition," by H. C. Sherman. Second Edition. (Macmillan, New York.) 1918. " Food Products," by H. C. Sherman. (Macmillan, New York.) 1914. "The Vitamins," by H. C. Sherman and S. L. Smith. (Chemical Catalogue Company, New York.) 1922. "Elementary Household Chemistry," by J. F. Snell. (Macmillan, New York.) 1914. "Dietetics for High Schools," by Florence Willard and L. H. Gillett. (Macmillan, New York.) 1920. OUR DAILY BREAD AND VITAMINS BY WALTER H. EDDY, PH.D. Professor of Physiological Chemistry, Columbia University ONE of the outstanding events in nutrition of the past decade has been the evolution of the vitamin hypothesis. Unfortunately the appli- cation of this hypothesis to the needs of the layman has provided the food and nostrum purveyors with material for advertising and exaggeration, and it is now essen- tial that the cold facts in the case be presented to the public if we are to avoid the evils that have arisen from this quackery. In this chapter I wish to outline briefly the significant steps that have led to our knowledge of vitamins, the relation of this knowledge to our previous conceptions of right feeding, the methods which are used to evaluate the vitamin content of foodstuffs, and some simple rules for guidance in food selection in view of the new discovery. Previous to 1906 the study of nutrition by laboratory methods has provided important basal principles for guidance in food selection. These principles are as fundamental and basic to-day as they were then, and the first fact to emphasize is that the vitamin discover- ies have merely provided knowledge with which to supplement these facts, not to supersede or overthrow them. 266 SCIENCE REMAKING THE WORLD The basal principles to which I refer may be sum- marized rather briefly. First, food is fuel. Like coal the amount of energy that a given food will produce can be measured in heat units and that is all there is to the calorie evaluation idea. The calorie is simply a unit to measure with, like the inch or the centimetre. Thanks to accurate instru- ments and chemical analyses, it is now easily possible to determine on the one hand just how many calories of energy you or I need to run our human machine for twenty-four hours, and on the other hand just how much of the various kinds of foods we must consume to pro- duce these calories. But even though a foodstuff measures up to our calorie needs the body requires other qualities. To produce energy alone we can use starches, sugars, or fats, but to rebuild the living cellular matter (proto- plasm) we require not only these foods but also others rich in nitrogen. The chemist calls starches and sugars, "carbohydrates." He calls the fatty substances, "lipins," and to the nitrogenous foodstuffs he has ap- plied the term "protein." For all of these collectively he uses the term "organic nutrients." Chemical analy- ses easily give the proportions of carbohydrates, fats, and proteins in any foodstuff and this information is now available to the public in the form of tables issued by the Government and to be found in the many standardized texts on dietetics. If the ordinary in- dividual will so select his foodstuffs as to provide fifty grams (about two ounces) of protein per day and to meet the calorie needs, he has satisfied most of what we VITAMINS 267 call the per diem nutrient needs of the human machine. Aside from the organic nutrients present in a food, however, it has been found that the body also requires certain mineral salts. The manufacture of bone, for example, is a matter of lime deposition and we are learn- ing that to deposit this lime as bone the body requires, not only lime salts, but a certain amount of phosphorus. Again the prevention of various bad conditions lumped collectively under the name of acidosis requires that our blood be kept nearly neutral in reaction and the carbo- nates and phosphates play an important part in this regu- lation. Mineral salts, then, constitute a fourth nutrient. We are accustomed, then, to say that the second principle for guidance in food selection is to make sure that the foodstuffs contain the proper kinds and amounts of nutrients, including under this term car- bohydrates, fats, proteins, and mineral salts. The next discovery was the demonstration that pro- teins differ in nutritive value and that not only must the body have its fifty grams of protein per day, but it is extremely fussy as to the kind of protein it demands. As a result of the studies of many chemists working in this field we know that proteins are to be thought of as mosaics made up of separate chemical pieces and that there are some eighteen of these pieces, nearly all of which are absolutely necessary to make a body- satisfying protein. These pieces are known chemically as amino acids, but the principle involved is covered if we say that not only must we be sure of the amount of protein, but we must also assure ourselves as to its quality or make-up. 268 SCIENCE REMAKING THE WORLD There are also foods which were originally despised because of their poor showing in the respects referred to above, which are now valued for another cause. The normal activity of our digestion demands a certain bulk to our food mixture, even though that bulk is se- cured by materials which are classed as indigestible. It is of course obvious that no matter how rich a food may be in the qualities outlined above, the nutrients must be of such a nature that the digestive juices can act upon them and so change them that they will pass freely from the digestive organs to the blood. If not they will fail to reach the muscle, nerve, skin, bone, and other structures they are intended to nourish. This property, then, demands that our foods be digestible, but if we attempted to feed a man on completely digesti- ble mixtures his stomach and intestines would in time become atrophied. In other words we must have pres- ent a certain amount of indigestible matter to provide bulk and stimulation to the lining of the digestive tract. The cellulose which forms the coating of starch grains, the connective tissue that forms the indigestible portions of meats, etc., are examples of such substances. We speak of them as roughage and they are mechanical necessities of our food mixtures which must not be neglected if we are to avoid constipation and like ills. In general, then, while our foods must contain digestible nutrients they should also carry a certain amount of indigestible roughage. Finally the form of the food offered is important. Eating is to a high extent a psychological affair. If the food is presented in an unpalatable form the body VITAMINS 269 can utilize it, but in time the mental antipathy reacts physiologically and the individual becomes badly affected thereby. It is worth-while always to pay at- tention to palatability. Osborne's and Mendel's studies on the significance of protein quality were conducted between 1908 and 1911 and actually published in 1911. At that time the principles mentioned above were supposed to have completely expressed the basis for guidance in food se- lection. To illustrate these principles let us consider for a moment the composition of a foodstuff which is universally recognized as a perfect type of food, milk. In the following table are listed the chemical facts which are necessary to establish the standing of this foodstuff in the light of the knowledge of 1906-1911. THE VALUE OF MILK AS A FOODSTUFF g (a) One quart of milk will produce about 700 calories of energy. If a baby's need were 700 calories per day one quart of milk would therefore meet this need without resource to other food. A man requiring 3,000 calories per day would, of course, need to consume a very large amount of liquid if he lived on milk alone and hence usually prefers to supplement milk with other less watery prod- ucts. (b) The nutrient content of ordinary cow's milk is as follows: Protein of good quality 3-3% Lipins 4.0% Carbohydrates 5.0% Mineral salts «-7% Water 87.0% Wt. of one quart 34.4 oz. or 2.15 Ibs. Amino acid content — All the essential ones It is also digestible and palatable. 270 SCIENCE REMAKING THE WORLD Such tabulation as the above is perhaps sufficient index of how to test out any foodstuffs concerning which we have similar data. In our introduction we called attention to one view- point which we wish to reemphasize here. The vi- tamin hypothesis has not changed any of the basal principles by which we judge food value but merely re- quires us to supplement that knowledge by an additional criterion. How has this supplementary material been derived ? What led to the vitamin hypothesis ? Briefly, two lines of investigation that at first may seem to have no relationship. First, the prevalence in certain parts of the world of a disease whose cause was unknown and whose toll of human lives justified scientific study. Second, the attempt of the nutrition students to prove that if we ate foods which met all the require- ments cited above we would get normal growth, and the failure of the experiments to demonstrate this. Since the word vitamin itself was coined as a result of pursuit of the first line of investigation we will consider that side of the story first. In the Orient, especially in East Asia, where the diet consisted largely of fish and white or polished rice, a peculiar disease often mani- fested itself to which was given the name beri-beri. This disease has been known for hundreds of years. Outside of the Orient the second greatest area was Brazil and the disease was also known, though less extensively, in many other districts of the world. The idea that this disease was of dietary origin seems to have first sug- gested itself about 1878-1880. In 1882 Takaki pro- VITAMINS posed to change the diet of the Japanese Navy from rice diet and to add meat, bread, fruit, and vegetables. The result was an immediate reduction in cases of beri- beri. Rice then was early indicated as one of the offending articles of diet in the production of this dis- ease. It would take too long to follow out all the in- vestigations that were developed after the idea that beri-beri was due to a certain dietary deficiency first appeared. We will mention only a few of the most important. Of these, the investigations directed or personally conducted by Eijkman, a Dutch investi- gator in Java, deserve special attention. To him we owe two very important contributions. The following table collected by Vordermann at Eijkman's suggestion from Javanese prison cases shows how rice was first convicted of being a casual agent. KINDS OF RICE IN DIETS NO. OF PRISONERS FED THESE DIETS NO. OF BERI-BERI CASES RATIO OF BERI-BERI CASES White rice I 5O.266 j.,201 I "?O Rice with partial silver skin Unpolished rice .... 35,082 96,530 85 9 1:416 1:10725 "A glance at this data shows how attention was fo- cused not only on rice but on the polishing of rice, or "silver skin," as the carrier of protection against the disease. In 1896 Eijkman made a very important ac- cidental discovery. He found that chickens fed upon the remains of foods used in a hospital for beri-beri died 272 SCIENCE REMAKING THE WORLD of a disease which he called "polyneuritis gallinarum" and recognized as similar to human beri-beri. With chickens as experimental animals he was then able to supplement his medical investigations and to demon- strate that beri-beri was brought about in the Java cases by long-continued consumption of white rice and that the act of polishing removes an important con- stituent of the rice. The Dutch investigators, how- ever, failed to see the full significance of their findings. Eijkman himself believed that the starch of the rice grain gave rise to toxins or poisons which acted on the nervous system and that this toxic action was prevented by material in the silver skin or, as he later showed, in the pericarp of the grain. The foundations laid by Eijkman stimulated many other workers to follow up his lead and his greatest contribution was in providing a test animal in which could be induced the disease and with which diets could be tested quantitatively. The search for the preventive substance to which rice polishings owed their beri-beri protecting power, how- ever, began actively with Eijkman's contribution in 1897. Other foodstuffs were studied and Grijns found certain beans to carry this protective substance.' Schaumann extended the list of curative substances to include yeast. Other workers then sought to determine the value of the curative material itself. It was thought at one time that phosphorus compounds were the re- sponsible factors. In his book, "The Vitamines," Casimir Funk, the author of the term vitamin, sum- marizes the situation up to the time of introduction ot the vitamin theory (1911) as follows: VITAMINS 273 To summarize our knowledge of the chemical nature of the active principle prior to the introduction of the vitamin theory (till 1911) the following may be set down with certainty: 1. The substance is soluble in water, alcohol, and acidified alcohol. 2. The substance is dialysable. 3. The substance is destroyed at 130° c. When we took up the question in 1911 it was not known whether the active substance was organic or inorganic, in nature, whether or not it was a constituent of proteins, nucleins, or phosphatides. It was not certain that we were not dealing with a ferment, nor was it known if the substance belonged to some chemical group already described, or to some new unknown class of substances. Casimir Funk began his researches in this field shortly prior to 191 1. He set himself the task of isolat- ing the anti-beri-beri substance from its sources and the establishment of its chemical identity. In combina- tion with Cooper, Funk had shown that when pressed yeast was boiled with 20 per cent, sulfuric acid for 'twenty-four hours and the sulfuric acid completely removed with baryta, the evaporated filtrate still ex- hibited marked anti-beri-beri qualities. This stability in the presence of an acid led him to believe that the substance must be an organic base. With this assump- tion he began a systematic investigation of large amounts of rice polishings, the results of which he pub- lished in 1911. In testing his fractions he made use of pigeons which had been shown, like chickens, to be particularly susceptible to this disease when fed on pol- ished rice. By careful fractioning Funk was able to isolate from 100 pounds of rice polishings less than 2-iooths of an ounce of needle-shaped crystals which melted sharply at 233° F. and were highly curative. 274 SCIENCE REMAKING THE WORLD Analysis of these crystals showed the presence of nitro-' gen. Hence, in a later publication Funk christened these crystals the anti-beri-beri vita-amine or "vitamine." Amine has long designated to chemists a substance basic in action and with a nitrogen content. Since the crystals prevented loss of life it was natural to call them the life (vita) amine. It is no discredit to Funk that later, largely through his own studies and partly through the work of others, the crystals which he be- lieved to be pure vitamin were found to consist mainly of something else. To-day we have not yet succeeded in isolating the pure substance but Funk's researches laid a basis upon which all fractioning attempts have been based. The later discovery of other types of these sub- stances developed a controversy in which he was criti- cised for his selection of a name but none of the substi- tutes proved more acceptable and his term is now in universal use. Drummond suggested recently that since the presence of nitrogen had not been demonstrated in what we now know as vitamin A and C, we drop the final e in the word and call them vitamins. Funk him- self rather deprecates this change but the suggestion has been generally accepted by workers in this field. Had the vitamin theory concerned solely this oriental disease and its prevention, we would not have had the extended public interest that exists in the subject to- day. To see how this has come about we must turn to the second line of investigations in 1906. Hopkins and his pupils in England had arrived at an interesting re- sult in connection with their attempts to prove the ade- quacy of the food evaluation principles which we have. VITAMINS 275 listed. As a result of feeding mice on food mixtures composed of purified nutrients and meeting all the views expressed in our qualifications for a perfect food, the animals failed to grow. Hopkins expressed his views at the time as follows : But further, no animal can live upon a mixture of pure protein, fat, and carbohydrate, and even when the necessary inorganic ma- terial is carefully supplied, the animal still cannot flourish. . . . The field is almost unexplored, only it is certain that there are many minor factors in all diets of which the body takes account. In 1912, Hopkins first published the evidence on which he based these prophetic utterances. In this paper he demonstrated that a small quantity of milk contains something other than purified nutrient sub- stances of suitable quality, which is necessary to rat growth. He suggested the name "accessory factor" for this substance. In 1911 appeared the classical work of Osborne and Mendel in demonstration of the significance of the amino acids for maintenance and growth. They also used rat-feeding experiments and, like Hopkins, soon found that rats fed on purified substances alone would not grow. They believed that they had found an ac- cessory factor in milk, and by removing the protein from the milk obtained a factor which they called "Protein-free milk," and which, when added to their otherwise adequate food mixtures, actually promoted growth. They thought at first that the mineral con- tent of the milk was the answer, but when they care- fully analyzed their milk and substituted for natural 276 SCIENCE REMAKING THE WORLD protein-free milk an artificial mixture built of the salts in the proportions indicated in the analysis, it failed to produce the same effect. Stepp, a worker in Germany, had been attracted to the problem by the researches in protein quality and on the hypothesis that fats also might differ in quality experimented along this line with rats. He first demon- strated that bread and milk constitute a growth- producing diet for rats. He then extracted his bread- and-milk mixture with ether and found the residue inadequate for growth. This result seemed confirmatory of his viewpoint. But when he added to the residue purified fat which he assumed was what had been re- moved by the ether extraction, no growth resulted. On the other hand, the residue obtained by evaporation of his ether extract when mingled with the other residue produced normal growth. Stepp failed to grasp the entire significance of these experiments at the time, but he did provide additional evidence that milk contains something that is neither protein nor fat and which is essential to growth. In 1906 an experiment was begun at the Wisconsin Experiment Station which was planned by S. M. Bab- cock and carried out by Hart and Humphrey. In the later stages of this experiment McCollum and Steenbock cooperated. The object of this experiment was to determine whether rations for cattle, so made up as to be alike so far as chemical analysis would show, but derived each from a single plant, would prove to be of equal nutritive value for growth and the maintenance of vigour. The plants selected were wheat, corn, and VITAMINS 277 oats and a control group of a ration of the same chemical composition, but blended of corn, oats, and wheat. Young heifer calves were used, weighing 350 pounds and as near alike as possible. They were given all the salt they cared for, and allowed to exercise in an open lot free of vegetation, but the diet was absolutely restricted aside from salt (NaCl) to the particular ration. Dif- ferences failed to develop until after a year or more of time had elapsed. At that time the corn-fed animals were in much superior condition to all the others, even the control group. The wheat-fed ones were in the worst condition of all. Body condition, milk produc* tion, and the bearing of young paralleled one another in demonstrating the distinction between the diets. This experiment marked the entrance of McCollum into a field which was to make him one of the important contributors to the vitamin hypothesis. He began the study of the cause of the failure of animals to grow on mixtures of purified foodstuffs in 1907 and employed the domestic rat as the experimental animal. In 1909, McCollum introduced a new feature by seeking to in- crease the variety of foodstuffs in the diet as far as possible, but every organic component of the diet was required to be pure and free from phosphorus in any form, practically the only source of phosphorus in the diet being finely ground tricalcium phosphate. The paper in which the results were published is important, for it reported the first successful growth experiments with a food supply which was at the time considered to be composed only of foodstuffs which could be named. It seemed to demonstrate the adequacy of the views 278 SCIENCE REMAKING THE WORLD set forth in our basal principles for food selection and that the failure of animals fed upon purified food mix- tures such as those used by Hopkins and Osborne and Mendel is due to lack of palatability and consequent failure of the animals to eat enough. McCollum's food mixture was made up of the proteins edestin from hemp seed and zein from corn. With these were given corn- starch, wheat starch, milk sugar, glucose, cane sugar, butter fat, bacon fat, and cholesterol and a salt mixture. The striking result was normal growth. In 1909, Osborne and Mendel began their work to evaluate the importance of the protein components of the diet. In- stead of duplicating the diet of McCollum they substi- tuted a simple mixture consisting of milk-casein, starch, lard, and a salt mixture recommended by Rohmann. These animals, unlike McCollum's, failed to grow and by carefully measuring the food intake it was proved that this failure was not due to lack of appetite. At that time no one was able to see any important chemical difference between the two diets. But by substituting for 28 per cent, of the diet the milk residue which they called protein-free milk, they obtained growth. It would take too long to follow out all the lines of this experimentation. Out of it came the important information which has brought us recognition of the differences in protein quality. But from the vitamin viewpoint it was still more important. As a result of McCollum's study of his own diet he finally demon- strated the presence of a hitherto unsuspected factor in his butter fat that is absent in lard. He also found that egg yolk contained this substance. At the time of thia VITAMINS 279 discovery he believed that this was the key to the differ- ence between his diets and those of Osborne and Mendel and he christened this new substance "unidentified dietary factor fat-soluble A." But there was another factor in the mixtures en- tirely unsuspected by either McCollum or Osborne and Mendel at the time. This factor was present in the protein-free milk and also in McCollum's lactose. The publication of Funk's work and his vitamin suggestions set the investigators on a new trail. McCollum ob- jected to the idea that his fat factor was Funk's vitamin. Funk tried to show that the factor in butter fat was his vitamin substance. The literature of 1912-1915 is full of data bearing on this phase of the subject. Osborne and Mendel were able to confirm the presence of a stim- ulatory factor in certain fats as McCollum contended, but still believed that their protein-free milk supplied something else equally important. All the world knows to-day that the truth was that two vitamins were present. McCollum's butter fat did contain one, and we now call it vitamin A, or fat-soluble A. The one in his lactose and in the milk was proven to be appar- ently the anti-beri-beri type, and to reconcile the no- menclature it was listed as Funk's vitamin or "uniden- tified dietary factory water-soluble B." By the time this tangle was ordered, the field of in- vestigators had increased enormously and universal recognition was now given to the idea that in addition to nutrients of proper kind and quality, animals require for their growth and maintenance at least two other chemical substances hitherto unsuspected. It really 280 SCIENCE REMAKING THE WORLD didn't matter much what these were called. We might have adopted Hopkins' term, "accessory food factors," or McCollum's phrases, "unidentified dietary factors fat-soluble A and water-soluble B," but Funk's term at least provided brevity and by common consent these factors have become vitamins A and B. It now became fashionable to suspect diseases of hitherto unknown cause to be matters of vitamin de- ficiency. Scurvy had been known for years and its prevention by the use of lime juice had earned a name for the British mercantile navy of "lime juicers." Two workers in Europe, Hoist and Frohlich, published in the years 1907-1912 a series of brilliant studies which appeared to demonstrate this disease to be due to the absence of a specific vitamin, unlike the anti-beri-beri type and carried in abundance by substances such as lemon and orange juice. McCollum, however, re- ported in 1918 certain observations on experimental scurvy in guinea pigs which seemed to him to prove that this disease was explicable as a result of the absorption of toxic products from the intestines of the animals. A new controversy arose. Partisans of the two views arose also, but in time the truth confirmed the view- point of Hoist and Frohlich and vitamin C was added to the list. This matter was barely settled when a new controversy began, this time over the causes of rickets. Mellanby in England, working for the British Medical Research Committee, arrived at a viewpoint which the Committee published and to which they gave their support. This view was in brief that vitamin A, in which cod-liver oil is especially rich, is not only a growth VITAMINS 281 factor and a preventive of eye disease as was already demonstrated, but was also the factor which determined the proper deposition of lime salts in bone formation. Mellanby believed it to be entitled to the term anti- rachitic vitamin. The whole problem of rickets and its prevention was then reopened. Much valuable new data developed. It was found possible to cure rickets by regulation of the phosphorus in the diet, by using the ultra-violet ray or direct sunlight and by the use ot cod-liver oil in the diet. The vitamin interest, how- ever, centred about the use of the oil. Butter fat, known to be rich in A vitamin, was shown to be value- less as a preventive. On the other hand cod-liver oil was shown to be many times richer in A than butter fat and it was felt that perhaps Mellanby was right and that the distinction was a matter of quantity in the dosage. In August, 1922, however, McCollum pub- lished a series of studies which seem to leave no other conclusion than that cod-liver oil owes its antirachitic power to a new vitamin, that the antirachitic vitamin is not vitamin A. For this McCollum suggests the term D unless it shall be shown conclusively that vita- min B is actually composed of at least two factors. Funk has already offered evidence that the B concen- trates contain a factor which is essential to the cure of beri-beri and another factor that seems to have a specific power in stimulating yeast growth. For the latter he had already suggested the term vitamin D. McCollum raises the question as to whether we should include in the vitamin series other factors than those proved of significance in mammalian nutrition. This 282 SCIENCE REMAKING THE WORLD matter is purely a question of nomenclature and we have at least satisfactory evidence to-day of five sub- stances which were hitherto unrecognized in dietary demands and which we consider entitled to names. The list is probably still far from complete. Very re- cently Evans and Bishop have shown that when rats are fed on diets adequate in every known way and in- cluding vitamins A, B, and C, they are often infertile. The addition of lettuce to the diet prevents this sterility. While the distribution of this fertility factor is still to be worked out it is certain that they are dealing with a hitherto unrecognized factor, perhaps the sixth vitamin. These new substances so far as present knowledge is concerned are all alike in being potent in very small amounts and in defying chemical separation or identi- fication except by physiological effects. It may well be that when isolated in free form they will show similar structure, but at present we have no data on which to base even a reasonable guess in this direction. The review preceding is essential to make clear ex- actly the relation of the vitamin discovery to proper food evaluation. Enough experimentation has been carried out to date to show that these factors are wide- spread in nature. The following table from the author's Vitamin Manual will give a little idea of thii widespread distribution: VITAMINS 283 SOURCE OF VITAMINS FOODSTUFF Meats: Beef heart . . . Brains .... Codfish Fish roe Herring .... Kidney Lean muscle Liver .... Pancreas . . . Pig heart . . . Vegetables: Beet root . . . Cabbage, fresh Carrots Cauliflower . . Celery .... Chard .... Lettuce .... Onions .... Parsnips Peas (fresh) . . Potatoes . . . Potatoes (sweet) . Spinach Cereals: Barley . . . . Bread (white^ Bread (whole meal) Maize . . . Oats . . . Rice polished . Rice (wbole grain) Rye . . Corn embryo . + In yellow o In 284 SCIENCE REMAKING THE WORLD FOODSTUFF "A" "B" «c" Cereals — Continued: Corn (see maize) . Malt extract O O O Wheat bran . . O + 0 Wheat embryo + + + + + 0 Wheat kernel . . + +H~f O Other seeds: Beans, navy +++ O Cotton seed + + +++ Peanuts + ++ Peas (dry) . . . •H ++ O Fruits: Apples .... ++ ++ Bananas . . . ? + ++ Grapefruit . . . +++ +++ Grape juice . . + -f- Grapes .... O + + Lemons .... +++ ++++ Limes .... ++ ++ Oranges +++ ++++ Pears .... ++ ++ Raisins .... + + Tomatoes . •f-r- +++ 4-+++ Oils and fats: Beef fat . . . + 0 0 Butter .... + + + + 0 0 Cocoanut oil 0 0 0 Cod-liver oil + +++ 0 0 Corn oil ... 0 0 0 Cotton seed oil 0? 0 0 Egg yolk fat . . ++++ 0 0 Fish oils . . . ++ 0 0 Lard .... 0? 0 0 Oleo, animal + 0 O Oleo, vegetable 0 0 O Olive oil ... 0 0 O Pork fat . . . 0? 0 Tallow .... O 0 0 VITAMINS 285 FOODSTUFP "A" "B" "c" Nuts: Almonds + + + + Chestnut . . + + + Cocoanut . ++ + + + English walnuts + + + Hickory + + + Dairy products: . Butter . . . ++++ 0 0 Cheese . ++ + ? Condensed milk ++ + 0 Cream . . . -H-+ + ? Eggs . • -, ++++ 4~f 0 Milk powder (skim) + +++ +? Milk powder (whole) +++ +++ 4-1 Milk whole . . . +++ +4-4- •H* Miscellaneous: Alfalfa . . a +++ +++ ? Clover . . +++ ++++ ? Honey . ' . ++ 0 Timothy +4- +++ Yeast cakes - . o 4-f o It will also serve to point an important viewpoint which needs special emphasis. When we select our daily diet now we must of course include our quota of vitamins. But in view of the small amounts essential, bear in mind that this selection can be made without going outside the usual list of foodstuffs. We need no pills or nostrums. The slogan of a quart of milk a day for the growing child is still good advice in more than its original sense. In milk, vitamins A, B, C, and per- haps D, are present in abundance. Green vegetables and fruits supply the A and C lacking in a purely meat 286 SCIENCE REMAKING THE WORLD and cereal diet. Look to your green stuffs. But let us learn to pick our vitamins out of the food market and there will be no need to go to the druggist. A final word is perhaps desirable to explain the com- pilation of a table such as shown above. How is such information obtained ? No other discover}' emphasizes more strikingly the value of animal experimentation as a means of furthering human knowledge. Until Eijkman discovered that beri-beri could be induced in fowls, no tool was available for measuring quantita- tively the amounts of the anti-beri-beri vitamin in foodstuffs. The white rat has provided all the data for distribution figures in regard to vitamin A and much for B. To the guinea pig the race is indebted for the proof of presence and quantity distribution of vitamin C. If we can find an animal in which we can induce pellagra, that controversy may be cleared up. In brief, then, several methods of experimentation are now in universal use in the study of vitamin nature or distribution, but all are alike in principle. They all consist in either feeding to the experimental animal a diet lacking in a given factor and then attempting cure by addition of the foodstuff under investigation, or incorporating the foodstuff in the original diet in varying amounts and noting the prevention or lack of prevention of symptoms that follow. In all these diets the principles laid down in our original list are utilized and are essential if we are to be sure the results measure vitamin deficiency. We end then, as we began, with reiterating that the vitamin hypothesis has not destroyed old ideas about VITAMINS 287 food selection, but merely extended our bases for se- lection. We continue to require calories, nutrients, proper protein quality, but to these we must now add vitamin content. Someone has compared vitamins to the spark in the gasolene engine. It does not replace the gas but makes it work. So in the animal mechanism the fuel is food, but the food fails to function properly without its controlling vitamins. GUIDE TO FURTHER READING "The Vitamine Manual," by Walter H. Eddy. (Williams & Wil- kins, Baltimore, Md.) "The Vitamines," by Casimir Funk. (Williams & Wilkins, Bal- timore, Md.) "The Vitamins," by H. C. Sherman and S. L. Smith. (Chemi- cal Catalogue Co., New York City.) "The Newer Knowledge of Nutrition," by E. V. McCollum. (Macmillan, New York City.) "Vital Factors of Foods," by C. Ellis and A. L. McLeod. (D. Van Nostrand Co., New York City.) "Vitamins," by Benj. Harrow. (E. P. Dutton, New York City.) "Scurvy Past and Present," by A. F. Hess. (Lippincott's, Phila- delphia, Pa.) "Deficiency Diseases," by R. C. McCarrison. (Oxford Univ. Press.) Some Comprehensive Reviews: "The Vitamins," by H. C. Sherman. Physiol. Reviews, 1921, i, page 598. Report on the Present State of Knowledge Concerning Acces- sory Food Factors, British Medical Research Committee, pub. by H. M. Stationery Office, London. "The Vitamine, Bibliographic Review," by W. H. Eddy. Ab- stracts Bacteriology, 1919? i"> page 313. "Vitamins," by J. F. Lyman. Bull., vol. xviii, no. 3, of the Ohio State University Agricultural Extension Service. 288 SCIENCE REMAKING THE WORLD "Newer Aspects of Some Nutritional Disorders," by A. F. Hess. /. Am. Med. Assn., vol. 76, page 693. "The Etiology of Rickets," by E. A. Park. Physiol. Reviews, 1923, iii, page 106. "Vitamins in Canned Foods," by E. F. Kohman. Nat'l Can- ners' Asso. Bull. No. 19 L (1922). "The Present Status of Vitamins," by K. Blunt. Journ. Home Economics, 1921, xiii, page 97. THE END INDEX Achievements and Obligations of Modern Science, I Alcohol, 42 Alfalfa Weevil, 197 Alizarin. 61 Alpha Particle, 81, 86 American Chemical Society, 19 American-Made Dyes, 71 Angell, James R., VII Aniline Dyes, 51, 65 Anthrax, 141, 143 Ants, 203, 206 Appleman, Charles 0., 223 Argon, 89 Aromatic Compounds, 60 Arsphenamine, 65 Artificial Colours in Foodstuffs, 53 Aspirin, 66 Aston, F. W., 91 Atomic Weight, 92 Atomic Structure, 82 Atoms, 88 Atwater, W. O., 252 Australian Ladybird, 194 Automobile, 30, 36 Autumn Leaves, 70 Bacterial Origin of Diseases, 64, 103, 106,136,138 Bacterium Pneumosintes, 108 Bailie, 115 Bakelite, 73 " Bayer 105, "67 Bees, 200 Benedict, F. G., 252, 253 Benzene, 55, 60 Beri-Beri, 270, 280 Black Heart, 244 Blackleg, 236 Bonjean, 55 Botanical Gardens, 162 Boyle's Law, 22 Browning, 62 Browntail Moth, 194 Bureau of Entomology, 192, 106 Burton, W. W., 18 Butterflies, 200 By- Product Coke-Ovens, 57 Caldwell, Otis W., viii, 133 California White Scale, 194 Calories, 248, 255, 266 Carbohydrates, 266 Carbolic Acid, 58, 73 Carnegie Institution of Washington, 253 Cellulose, 268 Charles's Law, 22 Chemical Elements, 92 Chemical Warfare, 69 Chemistry and Economy of Food, 247 Chemotherapy, 65 China Medical Board, 158 China, Medical Schools in, 43 Chlorine, 91 Cholera, 64 Clemenceau, 25 Coal-Tar, 48, 69 Coal-Tar Compounds, 70 Coal-Tar Dye, 51, 52 Cod-Liver Oil, 280 Coke Ovens, 56 Columbia University, 33, 247, 261, Conduction, 96 Congo, 37 Connecticut Agricultural Expcr* imental Station, 257 Corn- Borer, 197 289 290 INDEX Cotton Boll-Weevil, 195 Coulter, John M., 167 Creevy, 27 Curzon, 24 Darwin, Charles, 168, 173 Darwin, Erasmus, 172 Davis, 250 Degeneration of Potatoes, 225 Department of Agriculture, 192 DeVries, 175 Diphtheria, 66 Dirigible Balloons, 4 Disease Germs, 64, 103, 136 Drake, 14 Dunlop, 37 Eddy, Walter H., 258, 265 Educational Value of Modern Bo- tanical Gardens, 162 Ehrlich, 65, 68 Eijkman, 271, 272, 286 Electricity, 80, 95 Electrons, 80 Electrons and How We Use Them, 78 Embryology, 170 Emerson, 181 Energy, 79 Energy Values of Food, 252 Epidemic Influenza, 99 Epidemics, 151 Evolution, 167 Expenditure on Motor Cars, 30 Experimental Study of Evolution, *7S Explosives, 4, 57, 58 Fats, 259 Fermentation, 136 Food, 247 Food Chemistry, 249 Food Production, 179 Food Supply, 261 Ford, Henry, 26, 36 Forest, 213, 220 Formaldehyde, 73 Fruits, 259, 285 runk, Casimir, 273 Gallieni, 24 Gas Engine, 24, 41 Gasolene as a World Power, 12, 17 Gates, Frederic L., 99 Giant Potato Plants, 225 Gipsy Moth, 194 Gliadin, 257 Goethe, 172 Helium, 4, 82, 84 Hermit Crabs, 205 History of Evolution, 168, 171 Honey-Bees, 202, 210 Hongkong School of Tropical Medi- cine, 154 Hookworms, 67, 159 Hopkins, 250 House Fly, 190 How the Forests Feed the Clouds, 212 Howard, L. O., 190 Human Nutrition, 249 Humidity, 220 Hydrogen, 87 Hydrophobia, 145 Ichneumon, 208 Ideals of Science, 188 Immunity from Tuberculosis, 127 Indigo, 61 Industrial Revolution, 40 Influence of Coal-Tar on Civiliza- tion, 48 Influenza, 99 Ions, 90 Insect Enemies, 192 Insect Sociology, 199, 210 Insects, 190 International Office of Hygiene, 155 International Public Health, 150, 159 International Sanitary Bureau, 15? International Health Board, 159 Inventions, The Greatest, 28 Isotopes, 93 apanese Beetles, 197 enner, 142 ohns Hopkins University, 258 uvenal, 49 Kellogg, Vernon, 199 Kerosene, 18 INDEX 291 Kitchener, Lord, 58 Koch, Robert, 64, 68, 117, 123 Lamarck, 173 Leaf-Roll, 237 League of Nations, 155 Legislation Against Thinking, 6 Leopold of Belgium, 37 Lettuce, 282 Lime Juice, 280 Li pins, 266 Lister, 145 Louis Pasteur, and Lengthened Hu- man Life, 133 Lurainal, 66 Macaulay, 28 Madder, 61 Maeterlinck, Maurice, 45 Malarial Fever, 65, 191 Marco Polo, 13 McCollum, 250, 276, 279 Meaning of Evolution, 167 Meat Consumption, 261 Meats, 259 Mendel, G., 250, 260, 275, 279 Mendel, Lafayette B., 257 Methanol, 5? Methylene Blue, 66 Microbes, War Against, 63 Mills, John, 78 Milk, 259, 263, 269, 279, 285 Mineral Salts, 267 Modern Potato Problem, 223 Molecules, 84 Moore, George T., 162 Mosaic Disease, 236 Myrmica, 207 Naegeli, 123, 124 National Tuberculosis Association, US Nitrogen, 82, 84 Noguchi, 107 Novocain, 66 Nucleus of Atoms, 84, 85, 88 Nutrition Experiment*, 262 Oil, 42 Orthogenesis, 177 Osborne, Thomas B., 250, 255, 269 275, 279 Otto Gas Engine, 20 Our Daily Bread and Vitamins, 265 Our Fight Against Insects, 190 Our Present Knowledge of Tubercii" losis, 115 Oxygen, 92 Pan American Union, 155 Parasites, 208, 235 Pasteur Institute, 154 Pasteur, Louis, vi, 133 Pasteurization, 137 Pear Thrips, 197 Perfumes, 54, 71 Perkin, W. H., 50 Petroleum, 41, 12 Pfeiffer's Bacillus, 100 Picric Acid, 73 Pine Bark-Beetles, 196 Phenol, 58, 73 Phonograph, 73, 75 Plant Lice, 204, 237 Potato Crop, 223 Potato Diseases, 233 Potato Improvement, 230 Potato Scab, 235 Potato Storage, 239 Potato Varieties, 229 Potato Wart, 235 Pott's Disease, 117 Precipitation, 221 Procaine, 66 Proton, 80, 259, 266, 267 Public Health, 151 Pulmonary Tuberculosis, 130 Rabies, 145 Radioactive Elements, 86, 95 Religion, 184, 188 Rice, 270 Rickets, 281 Road Construction, 39 Rockefeller Foundation. 158, 150 Rockefeller Institution for Medical Research, 99, 102, 154 Rosa, 2C2 ul, Edmond, 46 Royal Purple, 62 292 INDEX Rubber, 37 Rubber Plantations, 38 Rutherford, 86 Saccharin, 55 Salicylic Acid, 55 Salvarsan, 65 School of Tropical Medicine, 154 Scientific Spirit, 180 Scurvy, 280 Sea Anemone, 205 Seed Inspection, 227 Seneca Oil, 13 Shale Oil, 42 Sherman, Henry C., 247 Silkworms, 139 Sleeping Sickness, 67 Slosson, Edwin E., v, 12, 48 Smallpox, 142 Smith, Erwin S., 236 Smith-Noguchi Medium, 109 Smith, Theobald, 107 Social Wasps, 201 Soddy, 86, 93 Sodium, 89 Soft Drinks, 54 Spindling Disease, 238 Spontaneous Generation of Life, 136, „ '39. Spraying, 193 Standard Oil Company of Indiana, 19 Steam Engine, 19, 40 Stephenson, 27 Stepp, 276 St. Hilaire, 172 Sugar, 259 Symbiosis, 205 Synthetic Perfumes, 54, 71 Termites, 203 Thomson, J. J., 79, 91 Trinitrotoluene, 57 Trucks, 41 Trypanosomes, 67 Tsetse Fly, 191 Tubercle Bacilli, 65, 119, 125 Tuberculin, 123 Tuberculosis, 64, 115, 117 Typhoid, 3, 64 United States Department of Agri- culture, 252, 253 United States Forest Service, 212 University of Maryland, 223 Uranium, 85, 93 Vaccination, 142 Vanadium, 37 Vegetables, 259, 285 Vestiges, 170 Vincent, George E., 150 Vinci, Leonardo da, 26 Vitamins, 229, 250, 258, 259, 265, 267, 270, 283 Von Behring, no Von Kluck, 24, 58 Watt, 19 Wealth, 15 Wesleyan University, 252 Williams, Linsly R., 115 Wilson, 25 Wind Periodicity and Precipitation, 214 Winds, 216 Wintergreen, 55 Wheeler, 207 X-Rays, 95 Yellow Fever, 3, 191 Zon, Raphael, 112 Zoroastrians, 12