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A TREATISE

DISEASES

NEEVOUS SYSTEM.

WILLIAM A. HAMMOND, M. D.,

PEOraSSOK OF DISEASES OF THE MIND AND NERVOUS SYSTEM AND OF CLINICAL MEDICINE IN
THE BELLEVTTE HOSPITAI. MEDICAL COLLEGE; PHYSICIAN-IN-CHIEF TO THE NEW YOKK
STATE HOSPITAL FOE DISEASES OF THE NEKV0U8 SYSTEM, ETC.

■ WITH FORTY-FIVE ILLUSTRATIONS.

" Est quoddam prodire tenus, si non datnr ultra."

Hoe.

NEW YORK:
D. APPLETON AND COMPANY,

549 & 551 BROADWAY.

1871.

Entered, according to Act of Congress, in the year 1871, by
D. APPLETON & COMPAOT,
In the office of the Librarian of CongresB, at Washington.

PEEFAOE.

In the following work I have endeavored to present a
Treatise on Diseases of the l^ervoiis System, which, with-
out being super j&cial, would be concise and explicit, and
which, while making no claim to being exhaustive, would
nevertheless be sufficiently complete for the instruction and
guidance of those who might be disposed to seek informa-
tion from its pages. How far I have been successful will
soon be determined by the judgment of those more compe-
tent than myself to form an unbiassed opinion.

One feature I may, however, with justice claim for this
work, and that is, that it rests to a great extent on my own
observation and experience, and is therefore no mere com-
pilation. The reader will readily perceive that I have
views of my own on every disease considered, and that I
have not hesitated to express them.

The treatise embraces an introductory chapter, which
relates to the instruments and apparatus employed in the
diagnosis and treatment of diseases of the nervous system,
and five sections. Of these, the first treats of diseases of
the brain ; the second, diseases of the spinal cord ; the
third, cerebro-spinal diseases ; the fourth, diseases of nerve-
cells ; and the fifth, diseases of the peripheral nerves. Dis-
eases of the sympathetic nerve are at present so little un-

PREFACE.

derstood, if even one is recognized, that I have, for the
present, deferred their consideration.

I have also omitted several affections which, by some
authors, are classed with diseases of the nervous system.
The chief of these are cerebro-spinal meningitis, chronic
alcoholic intoxication, and Graves's disease. The first is
an epidemic febrile affection, similar in general features to
typhus fever, and in which the inflammation of the menin-
ges of the brain and spinal cord is altogether a secondary
phenomenon ; chronic alcoholic intoxication affects the ner-
vous system in conjunction with the organism generally,
and is no more entitled to be considered in a work like the
present than would be chronic poisoning from opium, hash-
ish, mercury, or other substance ; and Graves's disease—
although there is reason to believe that the sympathetic
and pneumogastric nerves are implicated — is probably es-
sentially an affection the starting-point of which is in the
blood.

My thanks are due to my friend Dr. E. L. Parsons,
Superintendent of the New York City Lunatic Asylum, for
the opportunity of selecting, from a large number of photo-
graphs of the patients in the institution under his charge,
such as appeared most fully to illustrate my remarks on in-
sanity.

The fourth volume of Prof Austin Flint, Jr.'s, " Physi-
ology of Man," which will be published dui-ing the coming
season, will, with the present treatise, constitute a complete
work on " The Physiology and Pathology of the Kervous
System."

162 West 34th Street,

New York, April 20, 1811.

00]^TEN TS.

IlTTEODTJCTIOIT, ....... 9

The Instruments and Apparatus employed in the Diagnosis

and Treatment of Diseases of the Nervous System, . 9

SECTION I.

DISEASES OF THE BRAIN.

Chap. I. — Ceeebkal Congestion, .... 33
Active Cerebral Congestion. — Passive Cerebral Congestion,
n. — Cerebral Anemia, . . . . .61
in. — Cerebral Hemorrhage, .... 74
lY. — Meningeal Hemorrhage, . . . .114

Haematoma of the Dura Mater.
V. — Partial Cerebral Anjsmia from Obliteration of

Cerebral Arteries, . . . . 119

Thrombosis. — Embolism.

VI. — Cerebral Softening, . . . . .137

VII. — Aphasia, ...... 166

VIII. — Acute Cerebral Meningitis, . . . .219
IX. — Chronic Cerebral Meningitis, . . . 281

X. — Tubercular Cerebral Meningitis, . , . 234

XI. — Suppurative Encephalitis oe Ceeebeitis, . 246

XII. — Diffused Cerebral Sclerosis, . . . 260

XIII. — Multiple Cerebral Sclerosis, , . . . 278

XIV. — Tumors of the Brain, .... 301
XV.— Insanity, ...... 324

General Principles. — Perceptional Insanity. — Intellectual
Insanity. — Emotional Insanity.- — Volitional Insanity. —
Mania. — General Paralysis. — Idiocy and Dementia.

CONTENTS.

SECTION II.

DISEASES OF TEE SPINAL COBD.

Chap. I. — Spinal Congestion, ..... 385
II. — Spinal Anemia, . . . . ^ . 396
Anaemia of the Posterior Columns. — Anaemia of the Antero-
Lateral Columns.
III. — Spinal Hjemoeehage — Spinal Meningeal H^moe-

EHAGE, ...... 440

ly. — Spinal Meningitis, ..... 444
Acute Spinal Meningitis. — Chronic Spinal Meningitis.

V. — Acute Myelitis, ..... 456

YI. — Spinal Softening, ..... 463
VII. — Sclerosis of the Anteeo-Lateeal Columns of the

Spinal Coed, ..... 471
YIII. — Sclerosis of the Posterior Columns of the Spinal

Cord (Locomotor Ataxia), . . . 484

IX. — Tumors of the Spinal Cord, . . . 517

X. — Seoondaet Degenerations of thiI Spinal Coed, . 623

XI.— Tetanus, ...... 529

SECTION III.

CEB EBBO-SP INA L DISEA 8ES.

I. — Hydrophobia, ...... 545

II. — Epilepsy, . . . . . .660

JII. — Catalepsy, . . . . . .590

IV. — Ecstasy, ...... 597

V. — Chorea, ....... 600

VI. — Hysteria, . . . . . . §19

VII. — Multiple Ceeebeo-Spinal Sclerosis, . . . 637

VIII. — Athetosis, ...... 654

SECTION ly.

DISEASES OF NEBVE-CELLS.

I.— Ateophy and Disappeaeance of Teophio Nerve-
Cells (Peogeessive Muscular Atrophy), . 663

CONTENTS.

• PAGE

Chap. 11. — Ateophy and Disappeaeanoe of Motoe Neeve-

Ceixs, . . . . . .677

Glosso-Labio-Laryngeal Paralysis.

III. — Ateophy and Disappeaeanoe of Motoe and Teo-

PHio Neeve-Oells, .... 689
Organic Infantile Paralysis. — Hypertrophy of Muscular
Connective Tissue.

IV. — FiTNCTioNAL Deeangements OF MoTOB Neeve-Celis, 706

Paralysis Agitans. — Writer's Spasm. — Lead Paralysis.

SECTION V.

DISEASES OF PERIPHERAL NERVES.

I. — Peeipheeal Paralysis, .... 722

Facial Paralysis.

II. — Peeipheeal Spasm, ..... 731

Facial Spasm. — Torticollis.
III. — Peeipheeal Anesthesia, .... 735
Anaesthesia of Cutaneous Nerves. — Anaesthesia of the
Fifth Pair.

lY. — Peeipheeal Hypeeesthesia (Feuealgia), . .739
Neuralgia of the Fifth Pair of Nerves. — Cervico-Occipital
Neuralgia. — Cervico-Brachial Neuralgia. — Dorso-Inter-
costal Neuralgia. — Sciatic Neuralgia,
Index,- 750

LIST OF ILLUSTEATIOlNrS.

Fio.

Page

1. ^STHESiOMETER, . . • Hammond, . 16

2. Dy.namometer, .... McUhieu, . . 19

3. DrNAilOGRAPH, ... " • • 20

4. Dpchksxe's Trocar, . . • Hammond, . . • 21

5. Electro-Magnetic Machine, . . " . . 23

6. Cerebral Coxtolutioss, . . • Broca, . . 195

7. Agraphia, .... Hammond, . 213

8. Dysamographic Tracing of Patient affected

with Multiple Cerebral Sclerosis, . " • • 284

9. Dtnamographic Tracing of Patient affected

with Multiple Cerebral Sclerosis, " . • 284

10. Malignant Tumor of Brain, . Otis, . . . 307

11. Cerebral Aneurism caused by Embolus, Prof. W. E. Smith, 316

12. Intellectual Insanity, . . Hammond, . . 350

13. Emotional Insanity,

14. Acute Mania, with Mental Exaltation, "

15. " " " Depression, " • • 364
jg' a « a " " . . 365

17. Dynamographic Tracing of Patient affected

WITH General Paralysis, . . " • • 370

18. General Paralysis, . • • " • • ^'^2

19. Idiocy, . . . • " . . 373

20. Dementia, . . 375

21. Chronic Spinal Meningitis, . . " , , 453

22. Dynamographic Tracing of Patient affected

with Posterior Spinal Sclerosis, " . .491

23. Dynamographic Tracing of Patient affected

WITH Posterior Spinal Sclerosis, " . • 492

24. Transverse Section of Spinal Cord, Lockhart Clarke, . 506

25. Longitudinal Section of " " •

356
362

LIST OF ILLUSTRATIONS.

Fio.

26. Tumor op Spinal Cord, . . Charcot, . . 519

27. " 519

28. Writing of Patient affected with Mul-

tiple Cerebro-Spinal Sclerosis, . Hammond, . . 651

29. Athetosis, 657

30. " (after photograph from Hubbard), " . . 661

31. Progressive Muscular Atrophy, . " . . 667

32. Glosso-Labio-Laryngeal Paralysis, . " . • 680

33. Writing of Patient with Glosso-Labio-

Laryngeal Paralysis, . . " . . 683

84. Glosso-Labio-Laryngeal Paralylis, . " . . 684

35. Muscle of Patient affected with Organic

Infantile Paralysis, . . " . . 693

36. Muscle of Patient affected with Organic

Infantile Paralysis, . . " . . 694

37. Muscle of Patient affected with Organic

Infantile Paralysis, . . " . . 694

38. Muscle of Patient affected wieh Organic

Infantile Paralysis, . . " . • 694

39. Muscle of Patient affected with Organic

Infantile Paralysis, . . " . . 695

40. Muscle of Patient affected with Organic

Infantile Paralysis, . . " . . 698

41. Muscle of Patient affected with Organic

Infantile Paralysis, . . " . . 699

42. Hypertrophy of Muscular Connective Tissue, " . .702

43. " " " " « . . 702

44. Muscle of Patient affected with Hyper-

trophy of Muscular Connective Tissue, " , , 704

45. Writing of Patient affected with Writer's

Spasii, .... " . . 712

DISEASES OF THE NERVOUS SYSTEM.

INTRODUCTIOK.

TEE mSTEUMENTS AND APPARATUS EMPLOYED IN TEE
DIAGNOSIS AND TREATMENT OF DISEASES OF TEE
NERVOUS SYSTEM.

Diseases of the nervous system, like those of the heart,
lungs, and larynx, require special means of investigation and
treatment. In no department of medical science has prog-
ress been more decided during the last decade than in that
class of affections considered in this treatise, and undoubt-
edly a great deal of the advancement is due to the instru-
ments and apparatus by which scientific research in this
direction has become practicable.

In the present chapter I propose to describe the instru-
ments and apparatus employed in the diagnosis and treat-
ment of diseases of the nervous system, and to explain the
methods by which they are used.

THE OPHTHALMOSCOPE.

The ophthalmoscope consists essentially of a concave
mirror perforated in the centre, and of a double-convex lens.
Several modifications of this arrangement are in use, but the
simplest instrument is, in my opinion, the best, and this is
Liebreich's.

It consists of a polished steel mirror about one and three-
2

xii

DISEASES OF THE NERVOUS SYSTEM.

quarter inclies in diameter, concave, and perforated in the
centre by a hole about the one-twelfth of an inch in diameter.
The edges of this aperture are bevelled so as to afford as lit-
tle obstacle as possible to the passage of the rays of light to
the eye of the observer.

The mirror is set into a bronze ring with a handle, and
there is attached also to this ring a clip for holding a concave
ocular lens, which in some conditions of refraction, either in
the eye of the patient or that of the observer, is necessary in
order to produce the necessary divergence of the parallel
rays emanating from the patient's eye, and thus render the
image of the fundus distinct. A direct image is thus ob-
tained. The lamp, which should furnish a steady flame, is
placed on the side of the patient's head corresponding to the
eye to be examined, and the eye of the observer very close
to that of the patient. This process gives a very satisfac-
tory view of the fundus with the optic disk and retinal ves-
sels, but requires care, and is more difficult than that by
which the inverted image is obtained.

In this case the observer illuminates the fundus with the
ophthalmoscopic mirror, and then interposes between the
mirror and the eye a double-convex lens which he holds
lightly between the thumb and finger, resting the ring fin-
ger on the forehead of the patient, so as to make the hand
steady, and the little-finger being disengaged so as to be
employed in raising the eyelid if necessary.

The object-lens should have a focal distance of about two
inches, and it should be held so as to bring the focus on the
pupil. The lamp is placed behind and a little to one side
of the eye to be examined. In order to see the optic disk,
the patient is told to look at the ear of the observer on the
side opposite to the eye being examined. In this way the
axis of vision is directed inward, and the optic disk readily
brought into view.

These examinations are made in a room lighted only by
the lamp used in the processes. It is sometimes necessary

INTRODUCTION.

xiii

to dilate the pupil witli atropia, in order to obtain a view of
the disk, but experience and tact will generally enable the
observer to dispense with this rather disagreeable procedure.

Ophthalmoscopic examinations require the observer to
possess a very thorough acquaintance with the anatomy of
the eye, and also with the science of optics. Unless these
qualifications are enjoyed, it will be much better to send the
patient to a competent ophthalmic .surgeon for an examina-
tion, than to rush to hasty conclusions based on the most
thorough ignorance. The real value of ophthalmoscopy in
diseases of the nervous system is in danger of being dis-
regarded through the sciolism of pert pretenders, who read
papers and write memoirs without ever having seen the optic
disk to recognize it.

Bouchut ' gives the following list of abnormal conditions
which are of importance in the diagnosis of diseases of the
nervous system :

Papillary congestion; peri-papillary congestion: papil-
lary anaemia, partial or general ; phlebo-retinal flexuosities ;
venous pulsation in the retinal veins ; dilatations of the reti-
nal veins ; retinal varices ; phlebo-retinal haemostases ; phle-
bo-retinal thromboses ; phlebo-retinal aneurism ; haemor-
rhages into the retina and choroid. The diseases in which
he tliinks ophthalmoscopy is valuable as a diagnostic means
are — the several varieties of cerebral meningitis ; cerebral
haemorrhage ; chronic encephalitis ; cerebral softening ; me-
ningeal haemorrhage ; chronic hydrocephalus ; tumors of the
brain ; contusion, commotion, and compression of the brain ;
general paralysis ; atrophy of the brain ; chronic myelitis ;
locomotor ataxia ; tetanus ; epilepsy ; essential convulsions ;
insanity, and several others of less importance.

To these may be added cerebral congestion, general and
partial ; cerebral anaemia ; and the various forms of sclerosis
affecting the brain and spinal cord.

' Du Diagnostic des Maladies du Systeme Nerveux, par I'Ophthalmoscopie,
Paris, 1866, p. 15.

XIV

DISEASES OF THE NERVOUS SYSTEM.

CEPHALOH^MOMETEK.

Although this instrument is intended for experiments on
the lower animals, it enables us to arrive at very definite
conclusions relative to the condition of the cerebral circula-
tion. I first described it in a paper read before the New York
Medical Journal Association in 1868, and shortly afterward
•published in the New York Medical Gazette.^ It was de-
vised in somewhat different form, independently of each
other, by Dr. S. Weir Mitchell and myself. The instru-
ment consists of a brass tube which is received into a round
hole made in the skull with a trephine. Both ends of this
tube are open, but into the upper end is secured another
brass tube, the lower opening of which is closed by a piece
of very thin sheet India-rubber, and the upper opening by a
brass cap, into which is fastened a glass tube. This inner
arrangement contains colored water. To this glass tube a
scale is affixed.

This second brass tube is screwed into the first till the
thin India-rubber presses upon the dura mater, and the level
of the colored water stands at 0, which is in the middle of the
scale. Now, when the quantity of blood in the brain is in-
creased, the liquid rises in the tube, being pressed upward
by the elevation of the thin rubber closing the lower open-
ing ; when the quantity of blood is lessened, the liquid falls
by its own gravity.

It was by this instrument that I was enabled to demon-
strate, in the most conclusive manner, that during sleep the
amount of blood circulating in the cerebral vessels is much
less than during wakefulness.*

^STHESIOMETER.

The sesthesiometer is an instrument for the purpose of
determining the degree of tactile sensibility possessed by the

'Also, JoiTRNAL OP PSYCHOLOGICAL Medicine, January, 1869, p. 4Y.
* Sleep and its Derangements. Philadelphia, 1869, p. 31Y.

INTRODUCTION.

patient. The instrument was devised in 1858 by Dr. Sie-
veking/ of London. Its value in cases of aberrations of sen-
sibility depends upon tlie fact, ascertained by Dr. E. H.
Weber, that the capability of distinguishing tvro impres-
sions made upon the skin simultaneously, varies in different
regions of the body according to the distance they are apart.
In sensitive regions, as the end of the finger, the two points
of a pair of dividers can be distinguished at about the
twelfth of an incli apart, while in tlie middle of the back
only one point is felt, though they are two incbes apart.
In accordance with this principle, the sesthesiometer is used
to determine the sensibility of the skin in various diseases,
it being well known that this is subject to variation.

Thus when the sensibility is intact, two points, touch-
ing the back of the band at the same time, can be distin-
guished as two points when separated an inch. If, in
examining a patient, we should find that, when the two
points were two inches apart, the patient felt but a single
impression, we should know that he had lost sensibility in
the cutaneous nerves of that part of the body.

Dr. Sieveking's sesthesiometer is nothing more than a
beam-compass. It consists of a rod of bell-metal four inches
in length, graduated into inches and tenths of an inch. At
one end is a fixed steel point ; another steel point is made to
slide upon the beam, and can be fixed at any distance from
the first by a screw whicli works at tbe top of the slide.

In 1861 I described an sesthesiometer which I believe
was the first used in this country. It consisted of a pair of
dividers, to one arm of whicb the arc of a circle, in brass,
was affixed. This arc was divided so as to measure tenths
of an inch. A short time since, I suggested to Mr. Stohl-
man, the instrument-maker, a modification of this instru-
ment, which for convenience is, I tbink, superior to all

• Brit, and For. Med.-Chir. Rev., January, 1858, p. 281.
» A Clinical Lecture on Chronic Myelitis. Delivered in the Baltimore Infirm-
ary, March 16, 1861. American Medical Times, January 8, 1861, p. 379.

xvi

DISEASES OF THE NERVOUS SYSTEM.

others. This, as closed, for the pocket-case, and open, as in
use, is seen in the accompanying woodcut (Fig. 1) * and
need- not be further described.

Fig. 1.

The minimum normal distances at which the two points
of the aesthesiometer can be distinguished in diflferent regions
of the body are stated in the following table : "

Point of the tongue ^ a line.

Palmar surface of the third finger 1 "

Red surface of the lips 2 lines.

Palmar surface of second finger 3 a

Dorsal surface of third finger 3 u

Tip of the nose 3 u

' First described by me in the Journal of Psychological Medicine, Octo-
ber, 1868, p. 830.

2 This table is quoted from Miiller s Philosophy, translated by Baly Lon-
don, ] 840, p. 752.

INTRODUCTION, XVii

The palm over the heads of the metacarpal bones 3 lines.

Dorsum of tongue, one inch from the tip 4 "

Part of the lips covered by the skin 4 "

Border of the tongue, an inch from the tip 4 "

Metacarpal bone of the thumb 4 "

Extremity of the great-toe 5 "

Dorsal surface of the second finger 5 "

Palm of the hand 5 "

Skin of the cheek 5 "

External surface of the eyelids 5 "

Mucous membrane of the hard palate 6 "

Skin over the anterior surface of the zygoma 7 "

Plantar surface of the metatarsal surface of great-toe. . 7 "

Dorsal surface of the first finger 7 "

On the dorsum of the hand over the heads of the meta-
carpal bones 8 "

Mucous membrane of the gums 9 "

Skin over the posterior part of the zygoma 10 "

Lower part of the forehead 10 "

Lower part of the occiput 12 "

Back of the hand 14 '•

Neck under the lower jaw 15 "

Vertex 15 «'

Skin over the patella 16 "

" " " sacrum 18 "

" " " acromion 18 "

The leg, near the knee and foot 18 "

Dorsum of the foot, near the toes 18

The skin over the sternum .' 20 "

" " " " five upper vertebrae 24 "

" " " " spine near the occiput 24 "

" " in the lumbar region 24 "

« " " " middle of the neck 30 "

" " over the middle of the back 30 "

The middle of the arm 30 "

« « « « thigh 30 "

THEKMOMETEK.

The thermometer is of use for the purpose of determinmg
variations of temperature in different parts of the body. It
should be graduated in tenths of a degree, and be held upon

xviii

DISEASES OF THE NERVOUS SYSTEM.

the part subjected to examination so long as the mercury
continues to rise or fall. Comparative determinations must
be made under precisely similar conditions.

becqtjekel's disks.

By means of these little instruments very slight varia-
tions of temperature can be ascertained. They consist of an
extremely thin plate of copper, about the size of a half-dime,
soldered to a thin rod of bismuth. This latter is contained
in a small tube of hard rubber furnished with a handle.
The disks are two in number, and by means of delicate silk-
covered wires are in communication with the poles of a gal-
vanometer. If a lower extremity, for instance, is subjected
to examination, one of the disks is placed uj)on it and the
other upon the corresponding part of the other limb. K the
temperature of both limbs be the same, the needle of the
galvanometer remains quiet ; if either be warmer than the
other, the needle is deflected to the north or south according
as one or the other limb has the higher temperature. By
this apparatus very much less than the hundredth of a degree
of temperature can be determined with absolute accuracy.*

THE DYNAMOMETER.

Several forms of an instrument for measuring the strength
of patients have been devised. The best and most generally
applicable is that of M. Mathieu, an instrument-maker of
Paris. It is very simple, and for measuring the strength of
the hands leaves nothing to be desired.

It consists, as is shown in the cut (Fig. 2), of an ellipti-
cal steel spring, to which is attached a semicircle of gilt brass,
upon which a scale is marked. An indicator, terminating
at one end in a cog-wheel, is capable of being moved freely
around the arc of the circle by a steel arm, upon one side of
which, cogs, fitting into those of the indicator, are cut. One

' See my memoir on the Pathology and Treatment of Organic Infantile Pa-
ralyais, in Journal of Psychological Medicine, No. 1, July, 1867, p, 53.

INTRODUCTION.

xix

end of this arm (the lower) touches the elliptical spring,
when the indicator points to the zero of the scale ; a brass
sheath upon the under side of the scale keeps this arm in
place, at the same time allowing it to move freely.

Fig. 2.

When the dynamometer is taken into the hand and
pressed, the two sides of the spring are approximated and the
steel arm, with the cogs being pushed by the lower side of
the spring, turns the indicator. One great advantage of this
instrument is that, when the pressure is taken oflP, the indica-
tor does not return to the zero, but remains at the point to
which it has been carried by the muscular power of the in-
dividual. We are thus enabled to see the extent of his
strength, after he has made his effort, and do not have to
watch him while he is using the instrument. It will also
be seen that this dynamometer can be used to measure tac-
tile force ; for if two hooks with cords attached be fastened
to the spring at the points a and traction on the cords
will approximate the two sides of the ellipse, and thus push
the steel arm so as to move the indicator as before.

THE DYNAMOGKAPH.

This instrument, which is of great value in the diagnosis
of diseases of the nervous system, is shown in Fig. 3.

It consists of the dynamometer B B, to which a toggle-
joint, moving a steel rod, is attached. This steel rod plays
through a hole in the end of the elliptical spring and moves
the lever which raises the pencil D. At A is a screw which

DISEASES OF THE NERVOUS SYSTEM.

varies the point at which the rod touches the lever, and thus
increases or lessens the delicacy of the indications. C is a
silvered plate upon which the paper is fastened by clips.
To the lower part of this plate, a strip of gilt brass, with cogs
cut in it, is attached. E is a gilt-brass box containing a
watch movement like that of the sphygmograph. A cog-
wheel which projects above the upper side of this box fits
into the cogs on the plate which carries the paper. The

Fig, 3.

wheel for winding up the clock-work, and the wire for stop-
ping it, or setting it in motion, are not seen in the figure,
they being on the opposite side of the box.

To set the instrument in action, the sphygmograph
movement is attached to the dynamometer at A. The clock-
work is then wound up, and the plate holding the paper
placed in the groove on top of the box E. The dvna-
mometer is then grasped by the hand and squeezed firmly ,*

INTRODUCTION.

xxi

the lever is thus moved, and the plate with the paper is
carried along by the cog-wheel. As it moves, the pencil
traces a line on the paper, the height and regularity of which
depend upon the firmness and steadiness with which the
dynamometer is pressed. As seen in the cut, the plate with
the paper is in motion, and has about half completed its
course. The patient should not look at the paper while
using the instrument.

The d^mamograph, therefore, writes down the muscular
power and tone of the individual, and likewise indicates the
perfection of what is sometimes called the muscular sense.
A person in good health will make a straight line with the
pencil. If there is paralysis of the muscles of the arm,- or
incoordination to the slightest possible extent, the line will
be irregular. The papers used may be marked with the date
and the name of the patient, and thus a record of his condi-
tion is preserved.

The pencil should be of the very softest lead, and the
paper should be rough and unsized.'

dtjchenne's teocae.

This very useful little instrument is shown in Fig. 4.
It is introduced open as at a. "When it has perforated the

Fig. 4.

muscle under examination, the small button at the under
part of the handle is pushed forward ; this propels a half-
cylinder of steel against the shoulder at the end of the tro-

* The first account of the use of the dynamograph was given by myself in
the Journal of Psychological Medicine, January, 1868, p. 139.

xxii

DISEASES OF THE NERVOUS SYSTEM.

car, and thus a small piece of muscle is detaclied and caught
in the cavity. The lower figure h represents the instru-
ment ready to be withdrawn. By drawing the button
back, the bit of fibre can be taken out, and is then ready
for microscopical examination.

ELEOTKIOAL APPAKATTTS.

The electrical apparatus required in the diagnosis and
treatment of diseases of the nervous system must be of two
kinds : one for furnishing the primary or galvanic current,
the other for yielding the induced or faradaic current.
Among the machines of the first category are those of
Stohrer, which are now made very satisfactorily by the
Galvano-Faradaic Manufacturing Company of New York, a
combination of Smee's cells which is manufactured by Dr.
Jerome Kidder, Electrical Mechanician to the New York
State Hospital for Diseases of the Nervous System, and
Daniell's batteries, which can be obtained of any electrical-
instrument maker. My own preference is for Kidder's
arrangement, which gives a very equable current and causes
very little trouble.

Of induced-current batteries I have on several occasions
before this commended those of Kidder, which are certainly
very admirable instruments. Recently, however, I have
used with great satisfaction an apparatus which is figured
in the accompanying woodcut (Fig. 5), which represents the
Portable Excelsior Electro-Magnetic Machine manufactured
by the Galvano-Faradaic Manufacturing Company, with all
the new improvements attached. This figure represents a
double-cell battery :

A. The graduated hinged battery-rod, to the lower end
of which the zinc plate is attached ; the hinge enables the
rod to be laid over horizontally when the battery is not re-
quired for action, thereby preventing an accidental immer-
sion of the zinc plate into the battery-fluid. The graduated
points on the rod exhibit the depth to which the zinc, when

INTRODUCTION.

xxiii

the rod is raised vertically and lowered down, becomes im-
mersed in the fluid, and indicates the battery-power obtained.
It can be retained in situ at any desired depth by means of
the binding screw. The brass spring 1 presses against the
thumb-screw of the rod when this is fully down in the cell,
and thereby maintains its conducting power, which becomes
deteriorated if it is not kept free from acid, and perfectly
clean.

Fig. 6.

B exhibits a combination of a movable platina disk,
with that part of the retracting armature lever wliich plays
against the adjusting-screw connecting it with the battery.
After continued use this point of the disk becomes oxidized
by the electric spark. When this happens, the shocks will
be irregularly generated. The disk can be turned a very

xxiv

DISEASES OF THE NERVOUS SYSTEM.

little round on its pivot, whereby a fresh surface of its
periphery will be brought to play against the point of the
adjusting-screw.

C. The rheotome, or adjustable elastic fork. Its free
end embraces the vibrating armature-spring or lever D be-
tween its prongs, so as to control the extent of the vibrations.
"When the rheotome is depressed, the upper end of the lever
can vibrate freely. "When it is raised, its prongs will, in
proportion to the extent of its elevation, limit the space
for the vibrations, and consequently increase their rapidity.
The control of the velocity of the vibrations is of great im-
portance in therapeutics and the diagnosis of disease. 2 is
a set screw, placed to work against the elastic fork, and reg-
ulate its position laterally, with reference to the lever D. E
represents the rheotrope or current-changer, between the
electro-magnetic machine and the electrodes, by which the
course of the primary and secondary currents can be in-
stantly changed without moving the conducting wires. F
represents the hydrostat or metallic capping, with stanch-
ions or binding-straps and thumb-screws 3 3 attached. In-
terposed between the hard-rubber covering plate and top of
the battery-cell is a soft-rubber packing. This capping can
be tightened to the desired extent, by means of the thumb-
screws 3 3 ; thus preventing the spilling or splashing over of
the liquid, impeding evaporation, maintaining the strength
of the battery-fluid, and maintaining the cells steadily in
their proper places. The hydrostat overcomes the great
difficulty hitherto experienced with all electric machines in
which liquids are used. By means of this invention they
are now rendered portable, and can be carried around
charged and ready for use, without danger of spilling the
battery-fluid. G represents an indicator or scale, affixed
beneath the movable coil 4, in English and French measure-
ment, graduated both ways, to enable the practitioner to
make exact record of the intensity of the electricity applied
to his patients at each seance^ so determines the different

INTRODUCTION.

XXV

degrees of susceptibility evinced on eacli occasion. As the
strengtli of the primary current is increased by drawing out
the movable coil 4, we count from left to right, when we
apply that current. The intensity of the secondary current
is increased by pushing inward the movable coil 4 ; in this
case, we made our record from right to left. These machines
are fitted up in black-walnut cases, with handles and locks
attached.

i^othing can exceed the efficiency and convenience of
this instrument. It possesses the great advantages of sup-
plying both the inducing and induced currents, and enabling
the physician to regulate the interruptions so as" to give the
shocks very slowly, a matter of great importance in the
treatment of paralytic disorders.

SECTION I.

DISEASES OF THE BEAm.

CHAPTER I.

CEREBRAL CONGESTION.

Cerebral congestion is of two kinds, which differ as re-
gards their mode of origin and symptoms. In the active
form, there is an increase in the amount of arterial blood cir-
culating in the vessels of the brain ; in the passive, the quan-
tity of venous blood is augmented. Occasionally the two
conditions coexist.

ACTIVE CEREBRAL CONGESTIOIf.

This is much the more common form. Of six hundred
and twenty-two cases recorded in my note-book, as occurring
in my private practice, five hundred and seven were of this
description.

Andral recognized eight varieties, all of which may, with
advantage, be comprehended in three, which are appropri-
ately designated from the chief feature characterizing the
attack, namely, the apoplectic, the epileptic, and the mani-
acal. Either of these may occur with scarcely a moment's
warning. Generally, however, there is a premonitory or
first stage, the symptoms of which, though well marked, are
3

DISEASES OF THE BRAIN.

not peculiar exclusively to any one of the fully-established
conditions mentioned. It is therefore impossible to predict
with accuracy, from the symptoms of this prodromatic stage,
whether the apoplectic, the epileptic, or the maniacal form,
will be developed. An attentive study of this stage should
always be made, and active measures taken for the relief of
the patient at a time when success can generally be obtained.

Symptoms. First Stage. — Among the earliest symptoms
of active cerebral congestion, wakefulness is especially no-
ticeable, and may be for a time the only evidence of disorder
which attracts the attention of the patient. He goes to bed
feeling weary, and as if sleep would very quickly overtake
him, but he is disappointed, for he obtains but an hour or
two of unquiet slumber, which is generally broken by un-
pleasant dreams. During the remainder of the night he
tosses restlessly from side to side of the bed, his mind either
occupied by the thoughts which have occurred to him through
the day, or else filled with the most preposterous ideas. He
consequently rises unrefreshed, feverish, and ill-prepared for
either mental or physical exertion.* So far as the mind is
concerned, there is an inability to give the attention to any
subject requiring much thought, and at times an absolute
want of power to get correct ideas of even simple matters.
This is especially seen in those who have arithmetical ques-
tions to solve, or long columns of figures to add up. Indeed,
mental labor of all descriptions is not only difiicult, but is
irksome in the extreme.

Before long the evidences of intellectual derangement
become more evident. The ideas are confused and without
logical arrangement ; the memory begins to fail, especially in
regard to recent occurrences ; and there seems to be a special
proclivity to forget words, and to substitute others having a
similar sound when pronounced, or appearance when written.

1 For a more complete account of wakefulness in all its relations, see the
author's treatise on " Sleep and its Derangements." J. B. Lippincott & Co.
Philadelphia, 18Y0.

CEREBRAL CONGESTION.

The names of persons and places are particularly difficult to
recollect. The judgment is weak and vacillating ; the most
strongly-expressed determination is changed apparently
without reason, and again there may be an impossibility of
arriving at a decision in cases where ordinarily but little re-
flection would be necessary. Any effort toward continuous
or severe thought increases the difficulties of the mind, and
augments the pain or uneasiness which generally exists in
the head. Illusions, hallucinations, or delusions, may be
present, but are not usually fixed ; and the patient will often
laugh at the absurd images he has seen, or ideas he has en-
tertained not five minutes before. Persons thus affected will
frequently reason clearly in regard to apparitions or voices,
of the unreality of which they are fully sensible.

The emotional system participates in the general mental
disturbance, and the passions are thus easily roused into ac-
tivity by slight exciting causes. Trifling circumstances
produce great annoyance, and the little every-day troubles of
life appear of vast importance. The disposition accordingly
becomes suspicious, peevish, and fretful.

In conj unction with these mental phenomena, there are cer-
tain physical symptoms of disordered cerebral action. Thus
there are pain, heat, a feeling of fulness or distention in the
head, or the sensation as if a tight band encircled it. Yertigo
is very generally complained of, and may be so severe as to
prevent the patient moving about. In some cases headache
constitutes the chief feature of the disorder, and is almost
constantly present. There are noises, such as roaring, rum-
bling, and ringing, in the ears, and occasionally loud reports
such as those produced by the discharge of fire-arms. Some-
times there are bright flashes of light from over-excitation of
the retinse, and at others dark spots — musccB voUtantes — ren-
der the vision indistinct. Ophthalmoscopic examination,
which should never be omitted, shows the vessels of the
retina to be increased in number, diameter, and tortuosity,
and occasionally the optic disk is found more or less con-

DISEASES OF THE BRAIN.

gested. The conjunctivse are suffused, the pupils are con-
tracted, there is intolerance of light, and motion of the eye-
balls is painful. Loud noises are likewise disagreeable. The
face is flushed, the carotids and temporals throb with more
than ordinary force, and there may be involuntary twitching
of one or more of the facial or other muscles. Bleeding from
the nose is not infrequent.

Sensation and the power of motion are usually affected,
and generally, though not always, on one side of the body
only. Thus the arm or the leg feels heavy, and a sensation
as of ants crawling over it, pins and needles sticking in it, or
as if the limb is " asleep," is experienced. These abnormal
sensations may be restricted to the face or the trunk. Ex-
amination with the sesthesiometer shows that the ability to
distinguish the two points of the instrument at the normal
distance apart is less on the affected side than on the other,
and that thus to get the sensation of two points they must
be more widely separated when applied to the diseased side
than is necessary for the corresponding parts of the sound
side. The muscular strength is also lessened generally, but
sometimes the difficulty is especially noticed in particular
muscles, such as the tibialis anticus or the deltoid, which, los-
ing a portion of their contractile power, cause the patient to
experience an awkwardness in raising the foot, or elevating
the arm from the side. The face, however, is rarely affected,
even when the muscular power is diminished on all the rest
of one side of the body, and the tongue, when protruded,
comes out straight. Careful observation will generally de-
tect some difficulty, perhaps slight, about the speech. Words
are not pronounced with as much distinctness as before, es-
pecially when the patient is fatigued or has been speaking
for some time. The linguals and labials among letters are
particularly troublesome, as well as all words which require
the nice management of the end of the tongue for their enun-
ciation. The articulation is thick, and sometimes whole syl-
lables are slurred over in a slovenly way.

CEREBRAL CONGESTION.

The other organs of the body are more or less deranged.
The pulse is unusually slow and full, the appetite capricious,
the digestion imperfect, the bowels costive, and the urine
scanty and high colored.

The foregoing constitute the ordinary assemblage of symp-
toms which are first met with m congestion of the brain.
Some of them may be absent, others so slightly manifested
as to escape ordinary observation, and others again so strong-
ly exhibited as to excite the grave apprehensions of the pa-
tient and his friends, and to require him to keep his bed.
Generally, however, they are not so severe as to prevent him
attending in a measure to his ordinary avocations, and they
may altogether disappear either spontaneously or in conse-
quence of appropriate medical treatment.

A spontaneous cure is, however, rare, and without proper
management on the part of the patient or his medical at-
tendant the symptoms pass sooner or later into one of the
fully-developed forms mentioned. Thus, of the five hundred
and seven cases already cited, the disease was arrested at the
first stage in four hundred and seventy-eight by appropriate
treatment, while there was not a single instance of sponta-
neous cure.

Second Stage, a. The Apoplectic Form. — Occasionally
this variety of cerebral congestion is initial, but ordinarily
it is preceded by the group of symptoms just detailed. In
either event the onset is generally sudden. The patient is
perhaps walking in the street, when he staggers, loses con-
sciousness, and falls. The loss of intelligence and sensibility
is, however, rarely complete, and may last but a few min-
utes or even seconds, though sometimes continuing for sev-
eral hours.

Paralysis to a greater or less extent is always present for
a time. One limb only may be afiected or those of one side,
or all four members. It is never complete, the patient being
able to perform some movements, though not to exert his
full strength. The face is rarely involved, and the patient,

DISEASES OF THE BRAIN.

thougli answering briefly when addressed in a loud voice,
speaks indistinctly and with difficulty.

The respiration is loud, slow, but rarely stertorous, and
it is not often that there is pufiSng of the lips and cheeks.

The pulse is slow, hard, and full. Sometimes the face
is flushed, and sometimes it is unusually pale. The sphinc-
ters generally retain their power.

The senses, though weakened, are often capable of being
exercised by tolerably strong excitations. A bright light
causes uneasiness and closure of the eyelids. A loud noise
is productive of discomfort, and a limb, when pinched, is with-
drawn.

The power of the mind is greatly lessened, and some fac-
ulties are altogether abolished. Answers more or less direct
are given to simple questions put in a loud tone, but even
moderate intellectual action seems to be impossible.

Gradually the attack passes off, leaving the patient in a
state of mental and physical depression, which may last for
several days. The paralysis usually entirely disappears, but
occasionally it does not, one or more limbs or muscles re-
maining permanently, or for a long time, disabled.

It sometimes happens, however, that the termination is
not so favorable. The vessels may remain congested, serum
may be effused, and death may result without there being any
vascular lesion. Two cases have come under my notice, in
which death ensued from this cause in first attacks.

A person who has once had a paroxysm, such as has been
described, is thereby rendered more liable to subsequent seiz-
ures, each one of which still further permanently impairs his
mental and physical powers. In one case, occurring in my
practice, there have been eleven attacks in five years ; and in
another, fourteen in four years. In both of these, and in sev-
eral similar instances I have witnessed, there was paralysis,
which had become more profound with each accession. It is
therefore inexact to say, as do some writers, that the paralysis
of cerebral congestion always disappears in a short tune.

CEREBRAL CONGESTION.

Of twenty-nine cases of fully-developed, active cerebral
congestion of wliicli I have notes, sixteen were of the apo-
plectic form.

J). The Epileptio Form. — This, like the variety just de-
scribed, may come on suddenly, or may be preceded by pre-
monitory symptoms. The phenomena of the attack do not
differ from those attendant on an ordinary epileptic parox-
ysm, except that there is never an aura, and no peculiar cry,
such as is so often met with in pure epilepsy. There is the
same tonic spasm, followed by clonic convulsions, which may
or may not be confined to one side of the body, and which
may or may not be followed by temporary or long-continued
paralysis. Stupor likewise supervenes, but is neither of so
long a duration nor so profound as in true epilepsy.

This form of cerebral congestion never occurs during
sleep, for then the brain contains less blood than when the
individual is awake. It may occur during stupor induced
by certain drugs, constriction of the neck, or the dependent
position of the head ; but stupor is not sleep, although the
two conditions are frequently confounded. Epilej)sy occur-
ring dm'ing ordinary sleep is never the result of congestion.
This point will be more fully considered under the head of
epilepsy.

After the stupor the patient may feel comparatively well,
or there may be delirium continuing for several hours. As
in the apoplectic form, there may be a succession of attacks,
and the mind and physical power of the patient are thereby
greatly weakened.

The variety under consideration is, perhaps, more liable
to occur in individuals past the age of forty, though I have
witnessed several cases in quite young persons. It is not
often met with in old age, and, when it is, is generally fatal,
probably from secondary lesion. Nine of the fully-developed
cases, of which I have record, were epileptic in character.

c. Ths 3faniacal Form. — This variety, though not so
common as either of the others, is yet not infrequent. It is

DISEASES OF THE BRAIN.

characterized by an accession of mental derangement not
materially different from that indicative of acute mania.
The delirium is of a very active character, the eyes are suf-
fused, the face is red, the head hot, the motility active, and
the whole manner, character, disposition, and mental pro-
cesses are changed. During the j^aroxysm the patient may
commit some crime of violence, and it almost always happens
that his combative proclivities are aroused. He may like
wise attempt to injure himself.

The attack may come on with great suddenness. In the
case of a gentleman recently under my charge, it was the re-
sult of eating a hearty meal in a great hurry at a railway
station. A few minutes after his return to the train he was
attacked with furious delirium, during which he attempted
to injure himself and all within his reach. He was seized
and held, but continued, as far as he was able, to bite, scratch,
and kick at those who were near him. The paroxysm lasted
about two hours. He then fell into a heavy stupor, from
which he did not arouse for two hours longer. For several
days his mind was weak, and there was numbness in vari-
ous parts of his body. Gradually, however, he regained his
former powers, but he suffered from occasional confusion of
thought and difficulty of speech, with headache and wake-
fulness for several weeks.

Paralysis, as in the other two forms, may be one of the
phenomena of this variety of cerebral congestion.

Death may take place during the attack, or from second-
ary lesions afterward.* Of the twenty-nine fully-developed
cases, four were of the maniacal form.

"What is called temporary insanity, mania ephemera, or
impulsive insanity, generally depends upon cerebral conges-
tion. The subject, therefore, is of vast importance in its
medico-legal relations.*

' The whole subject of cerebral congestion has been well considered by Cal-
meil in his "Traite des Maladies Inflammatoires du Cerveau." Paris 1859.
2 See a memoir by the author, entitled " A Medico-Legal Study of the Case of

CEREBRAL CONGESTION.

Thied Stage. — This period may be considered as begin-
ning after the immediate effects of tlie paroxysm, whether it
has been of the apoplectic, epileptic, or maniacal fonn, have
passed off. It is characterized by feebleness of body and
mind, by gastric or intestinal derangement, by pain in the
head with transient attacks of vertigo, and occasionally by
numbness and slight paralysis of one or more of the limbs.
Many of the symptoms met with in the first stage are again
found in this.

But the principal phenomena are those connected with
secondary lesions, such as inflammation, abscess, softening,
and adventitious growths of various kinds. These will be
considered under their proper heads.

It must not be forgotten that one circumstance always
exists, and that is, the proclivity to other paroxysms of some
one of the fully-developed forms.

PASSIVE CEREBRAL CONGESTION.

This condition is the result of causes which increase the
amount of venous blood in the brain. It is more commonly
met with in old persons. One hundred and fifteen cases out
of six hundred and twenty-two, occurring in my practice,
were of this form.

Symptoms. First Stage. — As in active cerebral conges-
tion, there is a premonitory stage, the symptoms of which
are similar to those previously described. There is, however,
a tendency to stupor, and the other phenomena are, in the
main, less strongly marked. Yertigo, pain, illusions, halluci-
nations, and delusions, are nevertheless generally present at
one time or another. But the stupor or tendency to somno-
lence is the most prominent feature, and the sleep, even when
comparatively natural, is attended with dreams unpleasant
or even frightful in character.

Daniel McFarland," in the Journal of Psychological Medicine for July, 1870.
Also published separately by D, Appleton & Co. New York, 1870.

DISEASES OF THE BRAIN.

The degree of congestion may be suddenly increased, or,
what is a more probable sequence, there may be effusion of
serum, and then the second stage exhibiting itself either in
the apoplectic, the epileptic, or the maniacal form results.

The proportion of cases of passive cerebral congestion
which pass to the second stage is greater than in the active
form of the affection. Thus, of the one hundred and fifteen
cases cited, thirty-one went on unchecked to the second
stage.

Second Stage, a. The Apoplectic Form. — Though this
variety may be developed suddenly as in active cerebral con-
gestion, it usually is more slowly evolved. In this latter
case a general numbness is commonly the first symptom, and
the drowsiness gradually increases. At first it is easy to
rouse the patient from this stupor, but eventually it is more
difficult, and at times impossible. The faculties of the mind
may likewise, at the beginning, be excited into a moderate
degree of activity, but with the advancing coma they are no
longer manifested. The cutaneous sensibility becomes less
and less ; the urine dribbles, from paralysis of the bladder
and its sphincter ; and the bowels, if not obstinately consti-
pated, allow their contents to pass involuntarily.

This condition may last for several weeks, and, though
recovery may take place, this is never complete. It gener-
ally ends in death.

Nine cases of the thirty-one were of this character.

h. The Epileptic Form. — This may not differ materially
from the epileptic form of active congestion except as regards
increased length of the fit and prolonged stupor. Gener-
ally, however, there is a repetition of the convulsive seizures,
and I am led to believe from my experience that there is a
greater tendency to biting the tongue. Paralysis is a more
common sequence, and is of longer duration.

Nineteen cases of the thirty -one were epileptic in form,

c. The Maniacal Form is not often met with in passive
cerebral congestion, and, when it is, the delirium, so far from

CEREBRAL CONGESTION.

being of a furious type, is low. The patient mutters to him-
self incoherently and exhibits great muscular restlessness, but
never attempts to do violence to himself or others. Coma
often occurs as a sequence. Three cases were of this type.

Causes. — The causes of cerebral congestion are : of the ac-
tive form, those influences which are capable of increasing
the quantity of arterial blood in the brain ; of the passive,
those which produce a similar eflPect upon the amount of ve-
nous blood circulating in the vessels within the cranium.
The causes of the first category induce activity of circulation,
those of the second torpidity.

The causes of active cerebral congestion may either
by their gradual operation initiate the premonitory stage, or
they may suddenly induce the development of this stage into
one or other of the varieties already described as constituting
the second stage. Among them are temperature either very
high or very low. Thus the disease is more frequent in hot
climates than in those of more temperate character, and in
the summer months than in the spring or autumn. It is,
however, more (jommon in very cold than in warm weather.
Thus Andral, of one hundred and fourteen cases, found that
twenty-six occurred in summer and fifty in winter. My own
experience is to the same effect, as will be seen from the fol-
lowing table, which embraces the cases in my private prac-
tice in the city of Is^ew York during a period of five years,
beginning January, 1865, and ending December, 1870 :

January .
February
March . .
April . . .

May

June

66
64
50
39
42
37

July

August . . .
September
October . .
November
December.

68
74
27
31
52
72

Total 622

An examination of this table shows that one hundred and
ten cases occurred in the autumn months, one hundred and

DISEASES OF THE BRAIN.

thirty-one in the spring, one hundred and seventy-nine in
summer, and two hundred and two in winter.

Passive cerebral congestion is very much more frequent
in cold than in warm weather.

The direct rays of the sun are capable of producing sud-
den attacks (insolatio), of which congestion is a prominent
feature, but which require separate consideration, and it is
not uncommon for artisans, whose heads are exposed to heat
from furnaces, to suffer in a similar manner.

Some authors contend that certain winds increase the
liability to cerebral congestion. Leuret, quoted by Mos-
mant,' could attribute an epidemic of cerebral congestion
which appeared at Charenton to nothing but a long-con-
tinued wind from the northwest. The supposition that
atmospheric electricity is a causative influence rests upon
nothing but hypothesis.

The ingestion of a large quantity of food into the stomach
may occasion passive congestion by the pressure which the
distended organ makes upon the large veins of the abdomen.
Rapid eating, even though the quantity of food be moderate,
may cause the active form of the affection by some influence
exerted through the sympathetic system.

Sudden and violent physical exertion, especially if made
in the stooping posture, is very liable to induce cerebral con-
gestion, Cliild-birth is an instance in point, and I have
known several cases to be caused by severe straining in the
water-closet. The constipation of the bowels rendering such
efforts at defecation necessary, is itself productive of the
disease.

A dependent position of the head and constriction of the
neck from the dress are also, by impeding the return of blood
from the head, liable to induce congestion of the passive form.

Certain articles of food and medicine, such as spices, al-
coholic liquors, opium, belladonna, quinine, etc., act either
by augmenting the action of the heart, or by their influence

' Essai sur la Congestion Cerebrale. Paris, 1858.

CEREBRAL CONGESTION.

on the sympathetic, paralyzing the vaso-motor nerves, and
thus increasing the calibre of the cerebral blood-vessels.

Tumors in the neck, or in other parts of the body where
the return of blood from the head may be impeded by their
pressure, likewise cause congestion. Other causes are to be
found in certain diseases, as fevers of various kinds,"erysipelas,
disorders of menstruation, the suppression of haemorrhagic
or other discharges ; local affections of the brain, as embolus,
thrombosis, tubercle or apoplectic clots, and sympathetically
by worms in the intestinal canal, or irritation existing in
other portions of the system.

But the most influential and common causes of cerebral
congestion are to be found in long-continued intellectual ex-
ertion, mental anxiety, or sudden, violent, or prolonged emo-
tional disturbance. It is from the action of such factors
that the premonitory symptoms are generally induced, though
they may, especially those embraced in the last-named cate-
gory, immediately develop a fully-formed attack. The fact
that cerebral exercise increases the amount of blood in the
head is made evident to all of us at times by the distention
of the superficial vessels, the suffusion of the eyes, the heat
and pain which we feel when we have overtasked our brains.
Cerebral action is always attended with hypersemia, just as
is the activity of the liver, the kidneys, or other organs. Ac-
tive cerebral congestion is thus induced, and is within cer-
tain limits perfectly normal. But these limits are liable to
be exceeded, and in this active period of the world's history
often are, and then the condition described as the first stage
of congestion is established. The vessels, from continued
overdistention, lose their contractility, just as does the india-
rubber band, used to keep a bundle of letters together, when
the package is too large or it has been kept stretched for a
long time. An additional disturbing force, heat, cold, an
overloaded stomach, increased mental labor, emotional ex-
citement, or any of the causes mentioned, may suddenly
evolve a fully-developed paroxysm.

DISEASES OF THE BRAIN.

Emotion acts in a similar manner, though, as has been
said, often with more suddenness. The emotions of shame,
of anger, and others, cause the face to become red from dila-
tation of the blood-vessels, and a like effect is produced
in the vessels within the cranium. If the emotion is very-
strong or lasting, a correspondingly-increased hyperaemia re-
sults.

There are certain circumstances which render the action
of the causes specified more effectual or powerful. These are
inherent in the individual, and may be classed as predispos-
ing causes. Among them are sex, the disease being more
common in males ; age, it being more frequently met with
in middle-aged or old persons ; hypertrophy of the left ven-
tricle of the heart, by which the flow of blood to the head is
directly increased ; dilatation of the right ventricle, by which
its power is diminished, and the return of blood from the
head impeded ; insufficiency of the auriculo - ventricular
valves, or constriction at the auricular or ventricular orifices
on the same side, by which a similar result is produced, and
perhaps, though this point is by no means established, short-
ness of the neck.

Diagnosis. — Cerebral congestion may be confounded with
cerebral haemorrhage, meningeal haemorrhage, embolism,
thrombosis, softening, epilepsy, urinaemia, stomachal vertigo,
and with the very opposite condition, cerebral anaemia. From
each of these affections it is, however, distinguished by well-
marked characteristics.

The premonitory symptoms are not liable to be mistaken
for cerebral haemorrhage, but this error may be made as re-
gards the second stage. The apoplectic form is, however,
distinguished from apoplexy due to extravasation, by the
fact that in it the loss of intelligence is rarely complete,
and that, when it is so, the mind is dormant but for a few
moments ; that sensibility and the power of motion are never
altogether abolished; that coma, when present, is rarely
profound; that the paralysis, when it exists, is seldom

CEREBRAL CONGESTION.

limited to one side of the body ; by the general absence of
stertor, and puffing of the lips and cheeks in breathing;
and by the short duration of the symptoms.

From meningeal hsjemorrhage it is discriminated by the
comparative lightness of the symptoms, and by the fact that
they do not progressively augment in severity or intermit in
violence.

Cerebral congestion and embolism present some features
in common, and it is therefore occasionally difficult to dis-
tinguish them. In the former, however, the pulse is slow
and the respiration regular and deep, in the latter the pulse
is more rapid, is often irregular, as is also the respiration ;
in the former there is increased heat of the head, in the lat-
ter the temperature of this part of the body is unchanged ;
in cerebral congestion the symptoms are transient, in embo-
lism they are more lasting ; in the former there is often a
distinct premonitory stage, in the latter the attack always
takes place without a moment's warning. In the former,
though there may be cardiac difficulties, they are different
from those predisposing to embolism, which are consecutive
to endo-carditis — generally rheumatic — and which implicate
the semi-lunar or mitral valves, and in the fact that recovery
from an attack of cerebral congestion is generally complete,
which is rarely the case in embolism.

From thrombosis cerebral congestion is diagnosticated by
the circumstances that in the former the progress of the dis-
ease is slow, that there is usually well-marked paralysis from
the beginning, that the phenomena indicating mental diffi-
culty are more strongly pronounced, that the articulation
and memory for words are more decidedly affected, and, not-
withstanding occasional remissions, by the persistency and
gradual advance of the symptoms.

In softening there is often a sudden loss of consciousness,
persistent hemiplegia, and death in a few days. Again, there
is delirium without paralysis or convulsions, and again there
is a gradual accession of the symptoms. This latter is the

DISEASES OF THE BRAIN.

only form liable to be mistaken for cerebral congestion. It is
attended with headache, feebleness of intellect, and a gradu-
ally-advancing paralysis generally, beginning in one of the
lower extremities, and extending to the whole of one side of
the body. The speech is always seriously impaired, and the
mental disorder is of a far graver character than that due to
cerebral congestion. The gradual advance of the affection
to a fatal termination is also a characteristic circumstance.

With urinsemia cerebral congestion may be confounded,
if only the more obvious head symptoms be taken into con-
sideration. The history of the case and full inquiry will
always, however, enable the proper discrimination to be
made. Thus in urinsemia the existence of kidney-disease as
evidencd by a chemical and microscopical examination of the
urine, the anasarca of the face or limbs, and the repeated at-
tacks of convulsions and coma, will be sufficient diagnostic
marks.

From epilepsy cerebral congestion is distinguished by the
fact that the former is not preceded by the group of symptoms
constituting the first stage of congestion, that the period of
greatest congestion of the vessels of the face and neck is at
the beginning of the attack, that an aura is often present, that
there may be a peculiar cry, that the patient does not stag-
ger and fall slowly to the ground, but drops as if knocked
down by a severe blow, and that the tongue is frequently
bitten. The reverse is the case as regards all these phenomena
in cerebral congestion. Nevertheless so accurate and expe-
rienced an observer as Trousseau, in his clinical lecture on
Apoplectiform Cerebral Congestion in its Relations to Epi-
lepsy and Eclampsia^ confounds the two conditions. Trous-
seau's views on this subject do not, however, appear to be
accepted by any large number of medical authorities. Epi-
leptic vertigo is, as w^ill be shown at the proper place, a very
different affection from any form of cerebral congestion, and

' Clinique Medicale. Tome ii., p. 56. Also Bazire's Translation. London,
1866, p. 19.

CEREBRAL CONGESTION.

is not likely to be confounded with it. Epileptic mania has,
likewise, very few points in common with the disease under
consideration.

In stomachal vertigo the attacks of dizziness are often
severe, but they are clearly associated with gastric derange-
ment, and only occur while the stomach is digesting its con-
tents. Other symptoms of dyspepsia will also be noticed,
while the mental and physical disturbances which constitute
so prominent a feature of cerebral congestion are absent.
The distinction, however, is not always made.

From cerebral anaemia the first stage of congestion is fre-
quently not clearly distinguished, and I have seen several
cases in which patients had been treated for the one condi-
tion when the other was indubitably present. In both there
are headache, sense of constriction, vertigo, noises in the ears,
numbness, mental confusion, loss of memory, inaptitude for
labor of any kind, and at times loss of consciousness. But
in anaemia the face is not flushed, the carotid and temporal
arteries do not throb with violence, the pulse is quick, feeble,
and irregular, the respiration is hurried, the pupils are dilated,
there are bellows murmurs at the base of the heart and in the
veins of the neck, and the general aspect of the patient is not of
that rugged appearance so generally associated with cerebral
congestion. In the syncope of cerebral anaemia the paleness
of the face, coldness of the skin, and feebleness of the heart's
action, will serve to draw the line between it and the apo-
plectic form of congestion. The ophthalmoscope will at all
stages prove of great value in the diagnosis.

Prognosis. — The prognosis is materially modified, accord-
ing to the stage of the disease present when the patient is
seen, and the form of attack from which he may be suf-
fering. Active cerebral congestion is a more favorable type
than the passive. If the affection has not gone beyond the
first stage, a fortunate issue may safely be predicted under
the use of suitable medical treatment. Of the six hundred
and twenty-two cases under my care, but sixty passed to the
4

DISEASES OF THE BEAIN.

second stage, and several of these had already suffered from
previous seizures ; no death took place in any patient dur-
ing the premonitory stage. The aj)oplectic form is the
most grave, and the prognosis is rendered more unfavorable
with each attack. The epileptic form is ordinarily not
dangerous to life, nor is the maniacal, except in old persons.
Occasionally, however, even in young and robust patients,
death ensues during the paroxysms of these forms.

The liability to secondary lesions, such as softening, cere-
britis, haemorrhage, aneurisms, general paralysis, etc., must
be taken into account when forming a prognosis. The
more frequent the paroxysms of any form, the greater the
risk of some such finality.

The habits of the patient are also important elements in
forming an opinion in regard to the ultimate result. If
these are bad, and are persisted in, the probability is that no
treatment will be of much avail in preventing a recurrence.
Moreover, by such a condition of the brain as the excessive
use of alcohol, inordinate mental exertion, or continual emo-
tional excitement induce, the chance of escaping some sec-
ondary morbid process is very much lessened.

Of the sixty fully-developed cases which have been under
my observation during the past five years, there were twelve
deaths ; four from the apoplectic form, all after repeated at-
tacks ; three from the maniacal, one of which was that of a
young man, about thirty years of age ; and five from sec-
ondary lesions. Of these latter, two were from softenino-
one from cerebritis, one from haemorrhage, and one from
general paralysis.

Morbid Anatomy.— There are certain appearances seen in
the brains of those who have died of cerebral congestion
which are characteristic, although it must be confessed that
some or all of them are occasionally absent. These are :

An increased size of the capillaries and large blood-vessels
both of the brain and the pia mater. It thus happens that'
when a section of the brain is made, the red points ordinari-

CEREBRAL CONGESTION.

ly seen are larger and more numerous than usual, and that
the pia mater presents in spots, or throughout its extent, a
red or rose-colored appearance.

The white matter of the brain is increased in density,
and the gray matter is red, or even violet in hue.

There is sometimes a large quantity of subarachnoidean
effusion, and the ventricles may contain an excessive amount
of fluid.

If there have been repeated attacks of cerebral conges-
tion, it is not unusual to find, by microscopical examination,
little granules of htematin in contact with the blood-vessels.
The same means of exploration show the minuter capillaries
to be more than naturally tortuous, and to have little aneu-
rismal swellings. These may or may not involve tlie whole
circumference of the vessel. Their presence and import
were first pointed out by Laborde.'

On making a transverse section of the hemisphere, a crib-
riform appearance is seen, if the patient has repeatedly suf-
fered from attacks of cerebral congestion, and especially if
he be advanced in years. This is due to the presence of
numerous little holes with sharply-defined margins. The
brain-tissue bounding these is generally without material
change, either in color or consistence. This condition, called
by Durand-Fardel, to whom the credit of first describing it
is usually given, " I'etat crible," ' is supposed to be due to
the fact that the vessels have been so distended during life
as to press with increased force upon the perivascular tis-
sue, and that, shrinking after death, they no longer fill their
former space, which remains empty. Calmeil ' Avas the
first to notice this condition. He has very often found in
maniacs the white substance, rendered cribriform by vessels
distended with blood, sometimes empty, but always greatly

' La Ramollissement et Congestion du Cerveau principalement consid^res
chez de Vieillard. Paris, 1866.

2 Traite Pratique des Maladies des Yieillards. Paris, 1854.

2 De la Paralysie consideree chez les Alienes, etc. Paris, 1826.

DISEASES OF THE BRAIN.

dilated. This state, although frequently met with in con-
gestion, is not uncommon in other pathological conditions,
such as the several forms of softening, of which, however,
congestion is often the first stage.

Pathology. — It is almost useless at this day to discuss the
question of the possibility of the quantity of blood in the
brain being subject to variation. Still it may be interesting
to recall briefly the facts which establish the affirmative in
the matter.

In the cases of infants in whom the interior fontanelle is
still open, the scalp is seen to be elevated above the level of
the skull when the head is dependent, and depressed when
the head is elevated.

The same fact is observed in persons who have suffered
injury of the skull, involving the loss of a portion of its sub-
stance. During strong emotional excitement, or the action
of any cause capable of increasing the force of the circula-
tion, the scalp is elevated. From the action of opposite
causes it is depressed. Both in infants and in persons who
have received injuries such as those cited, the scalp is seen
to be depressed during sleep, and to rise as soon as the indi-
vidual awakes.

A dependent position of the head causes a sensation of
fulness, or even pain, and blood may flow from the nostrils.
The eyes are observed to be " bloodshot," and the counte-
nance indicates congestion. A tumor, a ligature, or any
other cause capable of exerting pressure on the jugular veins,
will produce like effects. Ophthalmoscopic examination
under such circumstances shows the veins of the retina to be
enlarged, indicating that an obstruction exists to the return
of blood through the sinuses and veins within the cranium.
Post-mortem examination of persons dying, who, during life,
have suffered interruption to the perfect return of blood from
the head, reveals the existence of intracranial congestion.
Animals subjected to experiments calculated to act in the
manner stated, are after death found to have congested brains.

CEREBRAL CONGESTION.

In animals bled to death the brain is found anjemic to
an extreme degree.

Direct experiment still more positively establishes the
fact under consideration. If a portion of the skull of an
animal be removed, and the aperture be then securely closed
■with a watch-glass, the vessels will be seen to enlarge and
contract according to the cause brought into action, and the
brain will be correspondingly elevated or depressed.

By means of an instrument, devised, independently of
each other, by Dr. S. Weir Mitchell and myself, the degree of
pressure within the cranium can be accurately measured. It
is thus seen that the quantity of blood circulating in the brain
undergoes material variation.'

The anatomical arrangement of the blood-vessels of the
cerebral tissue is such as to admit of an enlargement of their
calibre without necessarily subjecting the perivascular sub-
stance to pressure. Robin ' discovered the existence of
sheaths around these vessels, and his observations were sub-
sequently confirmed by His,' who ascertained that the same
arrangement exists in the spinal cord. According to His,
" Fine transverse sections of a hardened brain, having its
vessels injected or otherwise, show that all the blood-vessels,
arteries, veins, and even capillaries, are surrounded by a
clear space, broadest in the case of the larger vessels, but in
all cases quite sharply defined externally. In transverse
sections the vessels are seen to be surrounded by a ring-like
space, and in parallel sections the space is seen on each side
of the trunk of the vessel, and follows it in all its ramifica-
tions."

^ For a more complete argument on the subject, and for a statement in de-
tail of the experiments of Mr. Durham and myself on this point, the reader is
referred to the author's monograph, " Sleep and its Derangements." Philadel-
phia: J. B. Lippincott & Co., 1870. The cephalo-haemometer referred to in the
text is described in that work (Appendix), and also in the introduction to this
treatise.

2 Journal de la Physiologic de I'Homme et des Animaux, 1859, p. 527.
* "Zeitschrift fiir "Wissenschaftliche Zoologie," 1865, B. xv., quoted in the
Journal of Anatomy and Physiology. Translation by Dr. Bastian.

DISEASES OF THE BRAIN.

These perivascular canals are lined by a hyaline mem-
brane, and are capable of being injected, and, in cases of
chronic congestion, may become permanently enlarged, so as
to cause the appearance referred to under the heading of
morbid anatomy.

The pathology of the subject receives further elucidation
from a consideration of the causes capable of giving rise to
cerebral congestion, and which have been already mentioned
in detail.

Treatment. — Eecollecting the two grand forms of cere-
bral congestion, the principles which should guide us in
treatment will be clearly apparent. In the active type of
the disease the force of the cerebral circulation and the
quantity of blood in the blood-vessels of the brain are to be
lessened ; in the passive variety the force of the circulation
is to be increased, and at the same time the accumulation of
blood in the veins to be diminished. In the active form of
this affection the abstraction of blood from the arm was for-
merly very generally practised, but is now rarely performed.
I have never seen a case in which it was required. Local
bleeding is more generally applicable, and a few cups to the
nape of the neck will often afford marked relief. Leeches
to the temples are also useful, though they are preferably
applied just inside the nostrils. I have many times wit-
nessed the most satisfactory results from a couple of leeches
thus used, and from accidental nasal haemorrhage.

Cold is another very useful agent in the treatment. It
may be applied to the nape of the neck, or directly to the
cranium, either as very cold water or in the form of ice.

The advantages of position should also be brought to
bear. The head should be kept elevated, especially during
sleep, and no severe muscular exertion should be taken while
stooping.

The clothing should be kept loose about the neck. As
derivatives, a mustard-plaster applied to the epigastrium is
often of service, and the same may be said of warm or even

CEREBKAL CONGESTION.

hot water to the feet. Blisters I rarely employ, though 1
have occasionally done so with advantage.

The constant galvanic current possesses the power of con-
tracting the cerebral blood-vessels, when so used as to stimu-
late the sympathetic nerve. For this purpose one pole, the
positive, should be placed over this nerve in the neck ; and
the other, the negative, on the neck, as low down as the sev-
enth cervical vertebra. The current from about fifteen
Smee's cells is sufficient, and it should not be allowed to
act for more than two minutes. If extreme vertigo be pro-
duced, the number of cells should be lessened. This prop-
erty of the primary current was first pointed out by Ber-
nard, Waller, and Budge, but its demonstration by the oph-
thalmoscope was first made by myself.' Observation with
this instrument, while the current is acting, shows that the
vessels of the retina contract, and hence there can be no
doubt that the result is produced upon those of the brain.
A similar effect is caused by passing the current directly
through the brain, the poles being applied to the mastoid
processes. A slight feeling of vertigo follows both when
the circuit is closed and opened. The good effects of this
practice are well marked, a few applications being often
sufficient to abolish the vertigo and unpleasant feelings in
the head, and to restore mental and physical activity.

Of internal remedies the number is not large, and those
which it is advisable to employ are generally effectual, with
or without the external measures mentioned, in entirely re-
lieving the patient.

First among these must be placed the bromide of potas-
sium. Over five years ago I pointed out the value of this

' See a memoir entitled " Spinal Irritation," read before the Medical Society
of the County of New York, January 17, 1870, and published in the Journal of
Psychological Medicine for April of the same year. Also another, " On some of
the Effects of Excessive Intellectual Exertion," in the Bellevue and Charity Hospi-
tal Reports for 1870. In both these papers, and in my lectures to the class of
the Bellevue Hospital Medical College, I have made distinct mention of this
fact.

DISEASES OF THE BRAIN.

medicine, and explained tlie rationale of its action. As
others have since claimed the discovery as their own, I hope
I may be excused for quoting the following passage from a
memoir upon an analogous subject,' in which the action of
the bromide is clearly indicated :

" Bromide of potassium can almost always be used with
advantage to diminish the amount of blood in the brain,
and to allay any excitement of the nervous system that may
be present in the sthenic form of insomnia. That the first-
named of these effects follows its use, I have recently ascer-
tained by experiments upon living animals, the details of
which will be given hereafter. Suffice it now to say that I
have administered it to dogs whose brains have been ex-
posed to view by trephining tiie skull, and that I have inva-
riably found it to lessen the quantity of blood circulating
within the cranium, and to produce a shrinking of the brain
from this cause. Moreover, we have only to observe its effects
upon the human subject, to be convinced that this is one of
the most important results of its employment. The flushed
face, the throbbing of the carotids and temporals, the suffu-
sion of the eyes, the feeling of fulness in the head, all dis-
appear as if by magic under its use. It may be given in
doses of from ten to thirty grains, the latter quantity being
seldom required, but may be taken with perfect safety in
severe cases."

Since then, experiments with the cephalo-haemometer and
ophthalmoscope have abundantly confirmed these views, and
more extensive experience in the treatment of cerebral con-
gestion has placed the matter beyond the possibility of a
doubt. Other observers have also confirmed the opinions
here expressed.

The prescription which I usually employ consists of bro-
mide of potassium, §j ; water, §iv; of this a teaspoonful is
taken three times a day in a little water. Occasionally the

' On Sleep and Insomnia. New York Medical Journal, June, 1865, p.
203.

CEREBRAL CONGESTION.

bromide is increased to 5 iss, and sometimes a saturated so-
lution— wliicli contains grs. xxx to 3 j — is used. I continue
the medicine till drowsiness, a slight feeling of weakness in
the legs, and contraction of the blood-vessels of the retina —
detected by the ophthalmoscope — are produced. The more
prominent head-symptoms generally disappear in four or five
days, and the results above-mentioned ensue in about ten days.

Latterly I have used the bromide of sodium in corre-
sponding doses instead of the bromide of potassium. It is
more pleasant to the taste, and does not cause so much con-
stitutional disturbance as sometimes follows the administra-
tion of the bromide of potassium in large doses.

In conjunction with one or other of the bromides men-
tioned, I very generally employ the oxide of zinc, which
experience has taught me is a powerful agent in relieving
cerebral congestion, and giving tone to the nervous system.
It should be given in doses of grs. ij, three times a day,
either in the form of a pill or powder, and to avoid any nau-
sea should be taken after meals. At the end of about ten
days it will generally be found that all symptoms of conges-
tion— subjective and objective — have disappeared, leaving
a little debility and mental depression. It then becomes
expedient to give tonics and restoratives, and those Avhich
have a special action on the nervous system are to be pre-
ferred. Among them, strychnia, phosphorus, and cod-liver
oil, stand first.

Strychnia may be advantageously administered in con-
junction with iron and quinine dissolved in dilute phosphoric
acid, as in the following formula : strychniae sul. gr. j ; ferri
pyropliosphatis, quinise sul., aa, 3j; acid, phosp. dil,, zingi-
beris syrupus, aa, § ij. M. ft. mist. Dose, a teaspoonful
three times a day in a little water. I prefer this extempo-
raneous prescription to any of the syrups or elixirs with like
ingredients. If for any reason the iron and quinine are not
indicated, the strychnia can be given alone with the dilute
phosphoric acid.

DISEASES OF THE BRAIX.

Phospliorus almost always acts well in such cases as those
under consideration. It may be given in the form of the
phosphorated oil, as in the following formula : ]^ . Olei phos-
phorat., 5ss; mucil. acacise, ^y, olei bergamii, gtts. xl.
M. ft. emulsion. Dose, gtts, xv three times a day. A very
elegant preparation of phosphorus is the phosphide of
zinc, which was imported at my request about two years
ago, by Mr. J^eergaard, the eminent pharmaceutist of this
city, and which I was certainly the first to use in this coun-
try. M. Moutard Martin, M. Dujardin-Beaumetz, my friend
M. Gueneau de Mussy, and other Parisian physicians, had
previously employed it. My experience with this medicine
has been very extensive. I have never known it to pro-
duce the least unpleasant effect, and have rarely been disap-
pointed in obtaining the full results to be expected from
phosphorus in corresponding doses. I am, therefore, not in
accord with Dr. M. Clymer ' on this point.

The chemical formula of the phosphide of zinc is P.
Znj, and consequently a grain represents a little more than
one-seventh of a grain of phosphorus. The proper dose,
therefore, is about the tenth of a grain. I usually prescribe
it in cerebral congestion, according to the following prescrip-
tion: Zinci phosphidi, grs. iij ; rosar. conserv., q. s. M.
ft. in pill, 'No. XXX. Dose, one three times a day. Instead
of the conserve of roses, grs. x of the extract of nux-vomica
may be substituted if strychnia is not being administered in
some other form.

Such is the treatment I have found to be most advanta-
geous in active cerebral congestion, and I rarely have occa-
sion to supplement it with other measures, unless some special
indication is to be fulfilled. Thus, if the bowels are consti-
pated, a mild purgative may bo given, or preferably an enema
of warm water or olive-oil ; or, if the urine is scanty and
high colored, saline diuretics are useful.

In the passive form of the disease it is sometimes advis-
' Nkw York Medical Journal, vol. x., 1870, p. 476.

CEREBRAL CONGESTION.

able to give stimulants, whicli may be done from the first in
conjunction witli the bromide of potassium or sodium. Al-
cohol in some form is to be preferred when it is well borne,
though carborate of ammonia is sometimes a useful substitute.
In several cases of passive cerebral congestion in old people,
and in one notable instance occurring in the person of a very
prominent, elderlj' gentleman of this city, I derived the
most satisfactory results from sulphuric ether inhaled from a
handkerchief to the extent of a teaspoonful, several times a
day. The pain, constriction, vertigo, numbness, wakeful-
ness, and inability to exert the mind, were lessened with
every dose, and finally entirely disappeared. Ether may
likewise be given by the stomach — gtts. xv several times
daily — in case the inhalation is contraindicated from any
cause.

Of course, any influence capable of interfering with the
due return of blood from the head should be counteracted at
once.

Hygienic treatment should in both types of the disease be
persistently carried out. The food should be nutritious, diges-
tible, and ample, though not excessive, in quantity. Alcohol
and tobacco, if used habitually by the patient, should be re-
stricted to moderate limits ; I have never seen the latter do
harm unless used to excess. Tea and cofiee may safely be left
to the patient's own inclinations and experience. I believe
more harm is done by suddenly breaking ofi' a habit even
though it be somewhat injurious, than by tolerating it within
due bounds. Exercise in the open air — walking, horseback-
riding, or driving — is always beneficial. The same cannot be
said of gymnastic contortions, which, to make them worse,
are usually performed in hot rooms. Bathing daily and sub-
sequent friction with a tape towel are exceedingly useful in
determining blood to the surface of the body. The Turkish
bath cannot be too highly commended.

But, above all, those persons who have brought on the dis-
order by inordinate mental exertion or anxiety must con-

DISEASES OF THE BRAIN.

sent to use their brains in a rational manner if they wish to
recover or to avoid future attacks. They have received a
warning, and, if they do not heed it, sooner or later other
diseases, more difficult if not impossible of cure, will make
their appearance.

The cause, whatever it be, must, if practicable, be re-
moved, and it must continue removed.

iJHAFTEH II.

CEREBRAL ANEMIA.

In cerebral anEemia the quantity of blood in the brain is
either reduced below the normal standard, or the quality
of the circulating fluid is impoverished. The first-named
condition is due either to direct loss of blood, to deficient ac-
tion of the heart, to impaired nutrition, or to some cause pre-
venting the due access of blood to the brain ; the second to
disease of some organ concerned in haematosis or to a general
cachexia.

The two states very often coexist, and they may properly
be considered together.

Symptoms. — In cerebral anaemia, suddenly induced from
profuse haemorrhage, the most prominent symptom is syn-
cope. Yertigo is generally an attendant, and there are pale-
ness of the features and coldness of the extremities. The
pulse is frequent, thread-like, and weak. The respiration
feeble and accelerated.

But, when the accession is more gradual, headache is very
generally present. It may be, and usually is, confined to a
limited portion of the head, sometimes to a spot not larger
than the point of the finger. A feeling of constriction, es-
pecially across the brows, is complained of, and the vertigo,
notably increased on rising from the recumbent posture, is as
troublesome a feature as in the worst attacks of cerebral con-
gestion. There is ringing in the ears, and loud noises are
not only painful but are exceedingly irritating to the ner-
vous system. The pupils are largely dilated, and are slug

DISEASES OF THE BRAIN.

gisli, contracting slowly and but little on exposure to a strong
light. These phenomena may be restricted to one eye, a cir-
cumstance which generally occasions needless alarm on
the part of the patient. The retinse are extremely sensitive,
and hence ophthalmoscopic examination is painful. When
employed, the vessels at the fundus of the eye are seen to be
small and straiglit, and the choroid is paler than is normal.

The complexion is pale, the lips almost colorless, or else
redder than in health. The skin is cold and clammy.

ISTausea and vomiting are present in extreme cases, and
convulsions of an epileptic character may occur. In the
rapidly-developed form of the disease caused by sudden and
great loss of blood they are always present, and in the milder
and more gradual variety they are occasionally seen. Fee-
bleness of muscular power is always met with, and there
may be general or partial paralysis with the usual derange-
ments of sensibility indicative of anaesthesia, such as coldness,
formication, and " pins and needles."

The mind, of course, participates in the general disorder.
In extreme cases, due to active haemorrhage, the patient is
completely insensible. In less severe forms there may be
all the gradations from low delirium to great mental irrita-
bility, or a condition of intellectual lassitude approaching
dementia.

Hallucinations and illusions are common in the slowly-
developed forms of cerebral anaemia, and may affect any one
or all of the senses. Those of siffht and hearina; are, how-
ever, more prominent. In the case of a young lady now
under my care, and whose only marked disorder is that un-
der consideration, the hallucination that she sees a black man
is almost constantly present. At times she converses with
this imaginary being, tells him not to trouble her, that she
no longers fear him, etc. She believes firmly in his presence,
and hence has a delusion.

In all cases of cerebral anggmia there is more or less
drowsiness, from the profound syncope of the rapid form to the

CEREBRAL ANEMIA.

rather agreeable languor present in slight cases. In instances
of medium severity the patient readily falls asleep in the sit-
ting posture, but recumbency induces wakefulness from the
fact that the quantity of blood in the brain is thereby sud-
denly increased above the habitual standard, and a state of
comparative hypersemia is thus induced. I have, in another
place,^ called attention to this form of insomnia, and adduced
several cases in illustration.

Examination of the heart by auscultation reveals the ex-
istence of bellows murmurs both systolic and diastolic. They
are heard more loudly at the base of the heart. There are
also very generally venous murmurs which are heard most
distinctly in the jugular veins, especially when the head is
turned toward the opposite side. Arterial murmurs may
also occasionally be perceived.

These sounds are sometimes heard by the patient, and are
then exceedingly annoying. I have now under my charge a
gentleman suffering from cerebral anaemia, who constantly
hears a sound originating apparently in the head, and which,
as he describes it, resembles that caused by a large shell
placed to the ear. That these murmurs are anaemic is shown
by the fact that they disappear under appropriate treat-
ment.

A form of cerebral anasmia met with in young children
is of great importance, from the fact of its liability to be con-
founded with another far more dangerous affection, almost
its opposite. This was first clearly described by Dr. Gooch,''
although previously noticed by other observers. In children
suffering from this affection, the symptoms, so far as they
are noticeable, are similar to those present in the anremia of
adults. The drowsiness is well marked, the head is cool, the
pulse is small and weak, the features are pinched, the pupils
large and insensible to light, and the fontanelle, if still open,

' " Sleep and its Derangements."

* On Some of the most Important Diseases peculiar to Women ; with Other
Papers. New Sydenham Society Publication. London, 1859, pp. 1'79.

DISEASES OF THE BRAIN.

lias the scalp covering it depressed. After death, the vessels
of the brain are found to be almost empty, and the ventricles
distended with fluid. From its resemblance in some respects
to hydrocephalus or tubercular meningitis, this affection was
called by Dr. Marshall Hall hydrocephaloid. The distinc-
tion, however, is so well defined that none but the most ig-
norant or superficial observers would fail to recognize it.

Causes. — Haemorrhage or other exhausting discharge ranks
first among the causes of cerebral anaemia. I have known
several severe cases induced by epistaxis, and one by the con-
tinued loss of blood from leech-bites. Hsemorrhoidal bleed-
ing has also caused it in my experience, lifo infiuence of the
kind is, however, more common than uterine bleeding, such
as occurs before, during, or after labor, from miscarriages
and abortions, especially if they are frequently repeated, and
from excessive menstrual discharge.

Chronic dysentery and diarrhoea, malarial and other fe-
vers, the rheumatic, strumous, and cancerous diatheses, dis-
eases of the bones and joints, and long-continued purulent
discharges, are likewise causes of cerebral anaemia.

I have several times seen the affection apparently caused
by congestion of internal organs. Niemeyer, referring to
this possibility, cites the fact that it may follow the use of
Jounod's boot. At the present time, when this appliance is
variously modified and extended beyond its legitimate use
by itinerant quacks, it is well to call special attention to this
liability. Several cases in point have come under my obser-
vation, and in one, a young lady suffering from epilepsy with
cerebral anaemia, whom I saw in consultation with my friend
Dr. J. Marion Sims, severe paroxysms were induced by each
application of the " exhauster." In this case the operator
placed the whole body, with the exception of the head, in a
vacuum. In another instance exhaustion from the leg alone
caused syncope every time the operation was performed.

Pressure or obliteration upon the arteries supplying the
brain is another cause. A lady was recently under my no-

CEREBRAL AN^.MIA.

tice in whom botli carotid arteries had been tied, for cirsoid
aneurism of the scalp, by the late Dr. Kearney Rodgers and
my friend Prof. W. H. Van Buren. When I saw her, sev-
eral years after the operation, there was well-marked cere-
bral ansemia, the most striking symptoms of which were
vertigo and drowsiness. Tumors of various kinds may act
in a similar manner. Feebleness of the heart's action, such
as results from fatty degeneration, may also occasion cerebral
anaemia.

As we have seen, excessive mental exertion is a common
cause of cerebral congestion. Strange as it may appear, I have
had several cases of cerebral anaemia under my care in which
the disease was clearly the result of a like cause, and these
were instances in which the brain had been overtasked to an
extreme degree. A little reflection will, I think, show that
such cases are strictly in accordance with what takes place
in other parts of the body. Thus we see the moderate use
of a muscle or set of muscles increase their size and strength.
Inordinate exercise induces hypertrophy, but, if the power
of the muscles be still more severely tried, atrophy results.
One of the worst cases of progressive muscular atrophy I ever
saw occurred in the person of a ballet-dancer, whose gastro-
cnemii muscles were the apparent starting-points of the dis-
ease. Excessive cerebral action produces exhaustion and
exhaustion causes anaemia, as surely as anaemia causes ex-
haustion.

The action of mental emotions is more obvious. We
know that some emotions increase the amount of blood in
the brain. Others diminish it, and sometimes with such sud-
denness as to cause syncope. Fear is one of these, and we
have all seen the face become pale under its influence.

Certain medicines are causes of cerebral anaemia, both by
their action on the vaso-motor nerves and in diminishing
the power of the heart. Tobacco, tartarized antimony,
calomel, oxide of zinc, and the bromides of potassium, sodi-
um, and lithium, are among the chief of these. I was the
5

DISEASES OF THE BRAIN.

first to point out this influence of the bromides, and in a re-
cently-published memoir ' have given several cases in illustra-
tion of its action. The drowsiness, vertigo, nausea, fainting,
weakness of the muscular system, numbness, failure of mem-
ory, mental aberration, pallor of the countenance, and anae-
mia of the retina, all go to show that the quantity of blood
in the brain is diminished. Eecent investigations not yet
published have convinced me that the oxide of zinc acts in
a similar manner.

Insufficient nutrition, either from deficient or improper
food or disease of the digestive or assimilative organs, is a
very common cause. Through its influence not only is the
absolute amount of blood lessened, but its quality is deterio-
rated. The quantity sent to the brain is hence diminished,
and that which is supplied is lacking in its proper proportion
of red corpuscles. Many of the cases of cerebral anaemia oc-
curring in large cities originate from such influences, and
likewise from the vitiated air of narrow and crowded streets,
from cold and from deprivation of light.

Diagnosis. — The principal affection with which cerebral
anaemia is liable to be confounded is cerebral congestion.
Indeed, there is no other which can be mistaken for it, if even
ordinary perception and judgment be exercised.

From this it may be diagnosticated by the history of the
case, and a careful inquiry into the etiology, by the fact that
drowsiness, not wakefulness, is a prominent symptom ; that
the pupils are dilated instead of being contracted ; that the
pain is more apt to be fixed in a limited part of the head
instead of being general, that it and the vertigo are increased
by the assumption of the erect position, and diminished by
lying down ; that the ophthalmoscope shows retinal anaemia ;

' On Some of the Effects of the Bromide of Potassium when administered in
Large Doses. Quarterly Journal of Psychological Medicine, January, 1869,
p. 46. In this paper I stated that one of the most constant phenomena was
contraction of the pupils. Very greatly increased experience has convinced me
that this is an occasional circumstance, which occurs during the early period of
administration only.

CEREBRAL ANJEMIA.

that the face is pale and the skin cold ; that the pulse is weak
and frequent, and that bellows murmurs are heard at the base
of the heart and in the veins of the neck. The effect of
stimulants and tonics in mitigating these symptoms, and the
fact that they are increased by exertion, and debilitating in-
fluences, are also important points to be considered in form-
ing a diagnosis. Attentive consideration of these differen-
tial phenomena will prevent a mistake which may be fatal to
the patient.

Prognosis. — The prospect of recovery in cases of cerebral
anaemia depends mainly upon the removal of the cause, and
the adoption of suitable treatment. In those cases which are
the result of sudden and profuse loss of blood, the prognosis
is grave, and this is especially so if the patient is pulseless
and convulsions have occurred. In such instances, even
though the haemorrhage has been arrested, it may be im-
possible to save the patient.

In the gradually-developed form the prognosis is gener-
ally favorable.

Morbid Anatomy. — The vessels of the brain and its mem-
branes are observed upon post-mortem examination to con-
tain less than the normal amount of blood. The tissue of
the brain is pale, and section shows a diminished number of
the red points in the white substance. Sometimes there is
an increased amount of serous effusion in the subarachnoid
space, bnt the ventricles are generally empty.

Pathology. — The questions to be discussed under this head
are similar to those connected with the same point in cere-
bral congestion. That the quantity of blood within the cra-
nium can be diminished as well as increased admits of no
doubt, and the fact that the symptoms grouped together as
indicating the existence of cerebral anaemia are really the
result of deficient blood-supply to the brain is equally cer-
tain. The experiments of Kussmaul and Tenner,* as well as
those of other physiologists, are perfectly convincing.

' Untersuchungen iiber TJrsprung und Wesen der fallsuchtartigen Zuckungen,

DISEASES OF THE BRAIN.

To observe in man the effects of even temporarily cutting
off the supply of blood to the brain, it is only necessary to
compress the carotid arteries for a few moments. I have
repeatedly done this in rabbits to the extent of producing
insensibility and convulsions. Jacobi' relates the following
symptoms as generally observed in the human subject : Dim-
ness of sight, dizziness, stupor, weakness in the legs, stagger-
ing, swooning, loss of consciousness, and sudden apoplectic
falling down.

Dr, Alexander Fleming ' tried the effect of compressing
the carotid arteries. " There is felt a soft humming in the
ears, a sense of tingling steals over the body, and in a few
seconds complete unconsciousness and insensibility supervene
and continue as long as the pressure is maintained. I have
recently performed this experiment several times, with the
effect of producing similar phenomena, together with pallor
of the countenance, dilatation of the pupils, and temporary
headache.

In many cases of cerebral anaemia, the cause, as we have
seen, resides in the blood-producing functions, and is such
as to cause the formation of blood which does not contain its
due supply of red corpuscles. Here, although there may be
no diminution in the actual volume of this fluid circulating
in the cerebral vessels, the effect is the same so far as the
nutrition of the organ is concerned, and hence the symptoms
of anjemia are slowly evolved.

Again, it cannot be doubted that spasm of the blood-
vessels produced through the sympathetic and vaso-motor
nerves explains the origin and continuance of many cases of
cerebral anaemia. It is in this way that mental emotions

Frankfurt, ISSV. Also, On the Nature and Origin of Epileptiform Convul-
sions, caused by Profuse Bleeding, etc. New Sydenham Society Translation,
1859.

^ Quoted by Kussmaul and Tenner.

> British and Foreign Medico-Chirurgical Review, April, 1855, p. 529, in a
paper entitled " Note on the Induction of Sleep and Anaesthesia by Compression
of the Carotids."

CEREBRAL ANEMIA.

act, and sometimes with such rapidity as to cause instant
death. This spasm may be kept up for a very considerable
period, with the effect of developing the ordinary symptoms
of cerebral anaemia, even after the emotion which originated
it has long since disappeared.

Treatment. — The first indication to be fulfilled in the
treatment of cerebral anaemia is to get rid of the cause. It
often happens that this is still in active operation when pa-
tients come under our care, and there is no hope of perma-
nent success till it is removed. Thus, if there is haemor-
rhage from a divided vessel, from the uterus, the bowels, the
lungs, or other part of the body, it must be arrested ; if there
is exhausting discharge from the air-passages, the intestines
or the genital organs, it must be stopped ; if the digestive or
assimilative organs do not perfectly perform their offices,
they must be put in good condition, if a tumor or other ob-
struction to the due course of the blood to the brain exist, it
must be removed ; and if the hygienic conditions surrounding
the patient be bad, or the food inadequate in quantity or
quality, they must be improved.

No medicine exercises so powerful an effect in cerebral
anaemia as alcohol in some form or other. Perhaps, all things
considered, the spirituous liquors, such as whiskey, brandy,
and rum, are more generally applicable. For the influence
is more rapidly felt, and there is not the same risk of excit-
ing or aggravating gastric disorder, as when vinous or malt
'liquors are used. The quantity must be regulated according
to the circumstances of each case, and should always be large
enough to materially increase the force of the heart.

But if this were the only effect of alcohol, its benefits in
cerebral anaemia would be but temporary, and would cer-
tainly be followed by a period of depression. Aside, how-
ever, from its stimulating action in the heart, its tendency is
to improve the appetite and digestive power, and to relax
any spasm of the blood-vessels that may be present.

Occasionally it happens that alcohol is badly borne by

DISEASES OF THE BRAIN.

ansemic patients. The brain has for so long a time been de-
prived of a due amount of its natural stimulus — ^blood — ^that
time is required to enable it to tolerate and be improved in
tone by the increased supply. Thus the physician will find
that in some cases the patients will be apparently rendered
worse by the remedy which of all others is calculated to do
thefm most good. The headache and vertigo are increased,
and the general feeling of debility and malaise greatly aug-
mented, and the complaint made that tlie liquor has " gone
to the head."

'Now, it must be recollected that the brains of anaemic per-
sons are in very much the same condition as the eyes of those
who have for a long time been shut out from their natural
stimulus — light. When the full blaze of day is allowed to fall
uj)on their retinae, pain is produoed, the pupils are contracted,
and the lids close involuntarily. The light must be admitted
in a diffused form, and gradually, till the eye becomes accus-
tomed to the excitation. So it is with the use of alcohol in
some cases of cerebral anaemia. The quantity must be small
at first, and it must be administered in a highly-diluted form,
though it may be frequently repeated. Cases in which this
intolerance of stimulants is exhibited are almost invariably
of long duration, and are as those in which from a like cause
wakefulness is produced by the recumbent posture.

The carbonate of ammonia, or the aromatic spirits of am-
' monia, may be given if there are any special reasons why alco-
hol should not be used, but they are not to be compared to it
in efficacy.

In very extreme cases ether is preferable for the time
being to any other remedy, on account of its diffusive na-
ture ; and transfusion may be necessary to save life.

As adjuncts to alcohol, the bitter tonics, such as quinine,
gentian, Colombo, and quassia, are useful. Iron is almost
always required, though there are patients who do not tol-
erate it. In such cases manganese may be substituted with
advantage. I have frequently used the sulphate, in doses of

CEREBRAL ANEMIA.

five grains, "with excellent results. When iron is borne, I
know of no better combination than that given on page 57.
Cod-liver oil is also a valuable agent in the disease under
consideration.

It must not be forgotten that food is the most important
factor in relieving chronic cerebral anaemia. The main per-
manent influence of stimulants and tonics is exerted upon the
appetite and digestion, and the blood and tissue forming func-
tions mainly as an excitant. The real strength must come
fi'om the food. This should, therefore, be of good quality ;
animal food, such as milk, eggs, and meats of various kinds,
forming its chief portion.

The influence of position should always be taken advan-
tage of to facilitate the flow of blood to the head, and the
erect posture avoided as far as possible, especially during
the early stages of the treatment. Thus the patient should
be encouraged to pass a good portion of the day in a recum-
bent position, and should be instructed to assume it at once
on the occurrence of any aggravation of the symptoms.

The opposite course is fraught with danger. Physicians
are often anxious that their patients should take physical
exercise, but it must be recollected that those who suffer
from cerebral ansemia have very little vital energy and a di-
minished amount of blood circulating through the organ
from which the greater part of their nervous power comes.
Muscular exercise lessens the energy, and still farther re-
duces the quantity of blood in the brain, for the muscles
require an increased supply while in a state of activity. To
be sure, after the strength of the system is in a measure im-
proved, the blood increased in quantity and quality, and the
brain supplied with something like its proper proportion,
moderate physical exercise is of the greatest service.

I have several times witnessed severe consequences from
the assumption of the sitting or erect position too soon after
a profuse haemorrhage, and in one case death resulted.

As regards mental labor, there is not much need of cau-

DISEASES OF THE BRAIN.

tion, for the reason that it is impossible for the patient to
undertake it to any dangerous extent. But, as he improves
in strength, the desire to make use of his increased power
may be manifested. It is, therefore, well at this time to
prohibit any such exertion as will probably be followed by
marked depression. Moderate mental exercise is, however,
far from being prejudicial, for it tends to increase the amount
of blood in the brain.

Emotional disturbance should also, as a rule, be avoided,
although at times it may be productive of great benefit, es-
pecially if it be possible to bring into action an emotion con-
trary to that which may have produced the disease. Thus
a lady became subject to cerebral anaemia, directly the result
of painful emotions due to domestic trouble. The difficulty
was very suddenly removed, or rather the knowledge of its
removal was suddenly communicated to her. The reaction
was very great ; she was thrown into a state of joyous ex-
citement, attended with considerable febrile disturbance, and
I was apprehensive for a time that her mind might become
permanently deranged, for there were hallucinations and de-
lusions of various kinds, and many symptoms of cerebral con-
gestion. But in the course of a few days, during which she
was kept in entire seclusion, and as far as possible from all
mental and physical agitation, she entirely recovered both
from the secondary and primary disorders.

One word in regard to what not to do. From what has
already been said in this and the previous chapter, the reader
will have perceived that it would be exceedingly injudicious
to administer any of the bromides in the treatment of cere-
bral anaemia. I should not, therefore, deem it necessary to
say any thing further in regard to this point, but for the fact
that I am very sure, from my experience, that wrong ideas
prevail among some physicians relative to this subject. I
see many patients affected with the disease under considera-
tion, who have been treated with the bromide of potassium,
and invariably with the effect of aggravating the difficulty.

CEREBRAL ANJEMIA.

Care in making a diagnosis and a knowledge of the fact
that the bromides lessen the amount of blood in the brain
are points which it is necessary to insist upon, even at the
risk of being tiresome by repeating what has already been
said.

CHAPTER III.

CEREBRAL HEMORRHAGE.

Under the designation of cerebral hgemorrhage I propose
to consider that disease which is often known as apoplexy,
hemiplegia, or a paralytic stroke, and which is due to the
rupture of a blood-vessel, and the consequent extravasation
of blood either into the substance of the brain or into its
ventricles.

Two forms of the affection, differing essentially only in
the extent or seat of the lesion, but presenting different symp-
toms, are to be distinguished ; these are the ajpoplectic and
paralytic. In the first there is loss of consciousness ; in the
second the mind, though perhaps impaired, is not suspended
in its action.

Symptoms. — Before the full development of the attack
there often is, for several days, a group of symptoms present
which indicate cerebral disorder. These are very much of
the same character as those denoting the first stage of cere-
bral congestion, but, though generally not so numerous, are
far more striking.

Among the more obvious is a sudden difficulty of speech
arising from slight paralysis of the tongue and otlier muscles
concerned in articulation. "Words are not pronounced with
the usual distinctness; the tongue seems to occupy more
space in the mouth than it should, and is not moved with
the requisite degree of promptness and rapidity.

The other muscles on one side of the face may be affected,
and hence there is a little distortion, lasting, perhaps, but
for a few hours.

CEREBRAL HEMORRHAGE.

Defects of sight may occur, usually characterized by the
presence of dark spots in the axis of vision. Such difficul-
ties are due to minute extravasations in the retinae, and are
always of most serious importance. I have known retinal
clots to precede by more than a year the occurrence of a
more severe lesion.

Bleeding from the nose is a common precursor, and when
occurring without being increased by severe muscular exer-
tion, blows, a dependent position of the head, or other obvi-
ous cause in a person over the age of forty, is always to be
regarded as a symptom of moment.

^Numbness limited to one side of the body is of itself suf-
ficient to excite apprehension. I have known several cases
in which this symptom was the only premonitory sign. It
may be present several days before, or may precede the at-
tack by only a few minutes.

In addition, there may be headache, vertigo, slight con-
fusion of mind, a tendency to stupor, and vomiting.

None of the premonitory symptoms may be present, and
then the attack, if of the apoplectic form, occurs with great
suddenness. Even if they have been noticed, there is more
or less of abruptness in the onset.

Thus the individual is perhaps standing engaged in con-
versation, when he is instantaneously struck with uncon-
sciousness, and falls to the ground as if shot ; sensibility and
the power of motion are abolished, and no signs of vitality
are apparent to the ordinary observer, with the exception
of the slow and labored action of the heart and respiratory
muscles. The breathing is stertorous, the lips and cheeks
are puffed out with each expiration, and the pupils are gen-
erally largely dilated and insensible to light.

Reflex movements are abolished at first, but after a few
moments they reappear, and are even more readily excited
than in health, owing to the . fact that the controlling influ-
ence of the brain is removed.

The voluntary power of swallowing is lost, but it is usu-

DISEASES OF THE BRAIN.

ally not difficult to cause contraction of the muscles of deg-
lutition by excitation of the pharynx. When these cannot
be produced, the prognosis is, if possible, increased in grav-
ity, for the reason that the extravasation is probably in the
medulla oblongata, or so situated as to compress it.

The urine and faeces are often evacuated involuntarily.

An apoplectic attack of this character usually terminates
in death without the patient recovering his intellect in the
slightest degree. If life should be prolonged for thirty-six
hours, the probability of a fatal termination is materially
lessened. I have never seen a case of cerebral haemorrhage
that was instantaneously fatal, and, although from anatomi-
cal and physiological considerations I admit the possibility
of such instances, I am persuaded that they must be rare.
Jaccoud ' expresses the opinion that death is immediate in
those cases in which the haemorrhage is in the medulla ob-
longata, or in those which occur in both hemispheres. Dr.
Hughlings Jackson,' on the contrary, though conceding from
theoretical grounds that hemorrhage into or near the me-
dulla oblongata might cause instant death, has never wit-
nessed such a termination ; and Dr. TVilks ' says that apo-
plexy is very rarely, if ever, a suddenly fatal disease, no
matter what part of the brain may be the seat of the effasion.
Among the reports of several thousand post-mortem exami-
nations at Guy's Hospital, there was but one in which death
was asserted to have been instantaneous, and that was a case
of meningeal haemorrhage. Even this was doubtful, for the
patient had fallen, some distance from the hospital, and was
brought in dead.

I have several times had cases under my observation in
which, it was said, death had been as sudden as though the
individual had been struck by lightning ; but careful inquiry

1 Traite de Pathologic Interne. Paris, 1870. Tome premier, p. 166.

2 On Apoplexy and Cerebral Haemorrhage. Reynolds's System of Medicine.
London, 1868. Vol. ii., p. 520.

3 Guy's Hospital Reports, 1866, p. 1V8.

CEREBRAL HEMORRHAGE.

and post-mortem examination liave either shown that the
observers were deceived, or that there had been no extrava-
sation at all, death being the result of heart-disease.

In the majority of cases attended with complete loss of
consciousness, the course of the disease is not so rapid or
hopeless as in the form just described. The patient falls, is
comatose, breathes stertorously, and presents a similar gen-
eral appearance, but after a time consciousness begins to re-
turn, and it is possible to partially rouse him from the con-
dition of insensibility. He turns over in the bed, though
with difficulty, and may attempt to speak. Articulation is,
however, indistinct, for the muscles of one side of the face
are paralyzed, and the tongue, from a like cause, is restricted
in its movements. The paralysis is found to exist in the
limbs of the same side, and involves the loss of sensibility,
as well as of motion, though rarely to the same extent. In
some exceedingly rare cases, perhaps not clearly understood,
the paralysis of the limbs is on the opposite side to that of
the face. A man thus affected was present at my clinic, in
October, 1870, at the Bellevue Hospital Medical College.
He was a patient under my charge at the New York State
Hospital for Diseases of the Nervous System, and had been
attacked several years previously. His history, as elicited
with great care by my clinical assistant and resident physi-
cian of the hospital, Dr. Cross, was perfectly clear on this
point.

The facial paralysis presents several points of great in-
terest in a diagnostic point of view. The affected side is
incapable of expression, but, so long as the patient does not
attempt any facial movements, scarcely any distortion is per-
ceived. Should he endeavor to open his mouth to spit or to
puff out his cheeks, the paralysis is at once perceived. Ow-
ing to the fact that the antagonism of the muscles is de-
stroyed, the face is drawn toward the sound side, the angle
of the mouth being slightly depressed. It is remarkable,
however — and the fact is of importance as a diagnostic mark

DISEASES OF THE BRAIN.

between the facial paralysis of cerebral hsemorrhage with
hemiplegia and the simple facial paralysis from injury or
disease of the eighth pair — that the patient does not lose the
ability to close the eye of the affected side.

If the fifth pair of nerves is involved in the lesion, sen-
sibility is impaired, which is never the case in simple facial
paralysis, and the masseter and pterygoid muscles, which
receive their motor influence from this nerve, will conse-
quently be paralyzed. The ability to masticate on the
affected side is therefore lost, and the cheek hangs lower
than on the sound side.

The tongue is also only paralyzed upon one side. When,
therefore, it is protruded from the mouth, the point deviates
toward the paralyzed side, owing to the uncompensated ac-
tion of the sound genio-hyoglossus.

All these paralyses occur on that side of the body oppo-
site to the seat of the lesion. The muscles are relaxed ordi-
narily, though sometimes they are in a state of tonic rigidity.
Generally, however, rigidity, when it exists, is in the mus-
cles of the non-paralyzed side.

The temperature of the affected side, as determined by
the thermometer placed in the axillae, is at first higher than
on the sound side, but at a subsequent period it becomes
lower.

It is rarely the case that the third nerve is affected.
"When it is, there is external strabismus from paralysis of the
internal rectus muscle, and ptosis from paralysis of the ele-
vator of the upper eyelid. The pupil is dilated, and is insen-
sible to light.

Another phenomenon is sometimes observed, and that is
the rotation of both eyes toward the sound side. This is ac-
companied by a like movement in the head, so that, if the
patient is paralyzed on the left side, the eyes and head are
turned to the right, and consequently, as the patient lies in
bed, the right side of the face rests on the pillow. I have
observed these symptoms in about one-third of the cases of

CEREBRAL HAEMORRHAGE.

cerebral haemorrhage which have come under my observa-
tion. They were present from the very beginning, and dis-
appeared in a few days.

Slight convulsive or involuntary movements are occa-
sionally noticed. The most frequent of these is yawning, a
symptom which Dr. Todd ' regards as troublesome, and even
unfavorable, but which, in my experience, is not very annoy-
ing or dangerous. The other convulsive actions may be on
the whole of either side of the body, or on both sides, or may
be restricted to a single limb or even a group of muscles.

Eeflex movements can always be excited, especially in
the lower extremity, by tickling the sole of the foot. Deg-
lutition, though imperfect, can generally be made to take
place by reflex action, unless, as previously stated, the haem-
orrhage is in, or in the vicinity of, the medulla oblongata.

In the less severe apoplectic form of cerebral haemorrhage
now under consideration, the urine and faeces are sometimes
passed involuntarily from paralysis of the sphincters, and
are at times obstinately retained from paralysis of the blad-
der and abdominal muscles.

The mental symptoms are at first scarcely distinguish-
able from those which are present in the severest form of
the disease. The coma and insensibility are complete, but
after a time, which varies in duration with the extent of the
lesion, consciousness begins to return. The patient opens
his eyes, and gives a little attention when loudly spoken to ;
and is perhaps able to express, to some extent, his wishes by
signs and gestures. Gradually the mental power increases ;
he attempts to speak, but his words are misplaced or forgot-
ten, and his articulation, owing, as already stated, to the pa-
ralysis of the face and tongue, is thick and indistinct. Those
words which are enunciated by the movements of the lips
and tongue are especially troublesome, while those formed in
the throat are not difficult to pronounce.

The mental characteristics of the patient will be found

* Clinical Lectures. Second edition. London, 1861, p. 708.

DISEASES OF THE BRAIN.

to have undergone a radical change. He is irritable, unrea-
sonable, and fretful. His sense of the proprieties of life,
which may in health have been very delicate, becomes ob-
tuse ; his memory is notably impaired, and his reasoning
power greatly diminished. The greatest change, however,
is perceived in the emotional faculties. He laughs at the
veriest trifles, and sheds tears profusely at the least circum-
stances calculated to annoy him. Even for years afterward
this peculiarity is noticed.

Such is the first stage of an attack of cerebral haemor-
rhage marked by apoplexy and paralysis, as ordinarily ob-
served when amendment takes place. It is often the case,
however, that this stage is not fully developed, owing to the
continuance of the haemorrhage. In such an event the coma
becomes more profound, the breathing more irregular and
less frequent, the pulse intermits and loses in force, the face
becomes purple from imperfect aeration of the blood, and
death ensues. In other cases a certain degree of improve-
ment may be attained, and then the haemorrhage may recur,
and the patient dies comatose. Taking, however, a case in
which the improvement lias been progressive up to the point
of partial resumption of the mental faculties, we find that a
second stage characterized by difierent symptoms often super-
venes. This is the period of inflammation.

It may begin at a variable time after the occurrence of
the extravasation, usually not later than the eighth day. It
is marked by febrile excitement and pain in the head, the
latter being often very severe. There is gastric derange-
ment, as evidenced by nausea and vomiting ; and convulsive
movements of the limbs, with contractions of the flexors of
the paralyzed side, are generally present. Delirium is also
a prominent feature. Sometimes there is obstinate wakeful-
ness, and at others a strong tendency to coma. This stage
may last three or four days, or at most five or six, when it
either causes death by extension of the inflammation from
the immediate vicinity of the lesion to other parts of the

CEREBRAL HEMORRHAGE.

brain, terminates in the formation of an abscess, or gradually
ends in resolution, with abatement of the symptoms.

Disregarding for the present the first two of these results,
we proceed with the consideration of the phenomena of a
case in which resolution takes place.

With the cessation of the inflammatory action, the im-
provement of the patient becomes very marked. His speech
is every day more distinct, his mind more active, his para-
lyzed limbs more capable of motion. Usually the leg recovers
power with much greater rapidity than the arm, and thus
the patient is able to walk tolerably well before he can raise
his arm from his side, bend the elbow, or extend the fingers.
The paralysis in the leg is most marked in those muscles whose
ofiice it is to elevate the foot, and this necessitates a peculiar
gait in order to avoid dragging the toes along the ground.
The abductors are rarely afifected to any great extent. The
patient in walking, therefore, throws the leg out from the
body, and then, swinging it around, clears the ground in this
manner.

In the upper extremity there is almost invariably a dis-
position toward contraction of the pectoralis major and minor
muscles, by which the arm is drawn across the front of the
thorax. At the same time the latissimus dorsi, the trape-
zius, the rhomboidei, the teres major and minor, are gener-
ally in a state of relaxation, and eventually tend to atrophy.
The elbow is slightly flexed, the wrist bent upon the forearm,
and the fingers drawn in toward the palm of the hand.
These actions may, in a great measure, be prevented by ap-
propriate treatment, and they may vary in extent according
to the gravity of the attack. It is a curious fact that the
muscles of respiration are never paralyzed in cerebral haem-
orrhage unless the medulla oblongate be in solved.

Trousseau ' has insisted, with great force, on the fact that,
when the arm regains power before the leg, the termination

^ Lectures on Clinical Medicine. Bazire's Translation. Part I. London,
1866, p. 16.

DISEASES OF THE BRAIN.

is always fatal. That this is the general result, I am very
sure from my own experience, but it is not invariable, for
there are now in the I^ew York State Hospital for Diseases
of the Kervous System two patients affected with cerebral
haemorrhage whose arms have improved to a very great ex-
tent, while the legs are still as much paralyzed as ever.

Now, with all these troubles of motility, sensibility may
likewise be affected to a greater or less extent. When this
is the case, the limbs of the affected side at first feel heavy as
if made of lead, and after a while numbness, as exhibited by
a feeling as if ants were crawling over the skin, or water
trickling over it, as if pins and needles were sticking in it,
or as if that part of the body were " asleep," is noticed.
Sometimes the sense of touch is greatly lessened, while the
ability to feel pain is scarcely impaired, and indeed is often
considerably increased. Again, there may be hypersesthesia
of the skin of the affected regions, and pain along the course
of the nerves.

The circulation is inactive in the paralyzed limbs, and
this, together with the deficient nervous power, tends to
cause a permanent reduction of temperature. The differ-
ence may amount to as much as five or six degrees, and, as
the ability to resist cold is diminished, the patient is obliged
to use additional covering on the paralyzed members.

From continued disuse, atrophy of the paralyzed mus-
cles always takes place unless suitable treatment be begun
at an early period.

Thus far we have only considered those attacks of cere-
bral haemorrhage which are accompanied with unconscious-
ness. One of these forms kills, without the patient so far
recovering as to show whether he is paralyzed or not, though
of course he is so to a profound degree ; the other allows
of more delay ; the brain can still act to some extent, and,
if death does not ensue from continuance of the haemorrhage,
the patient is found to be paralyzed on the side of the body
opposite to the seat of the brain-lesion. One other form

CEREBRAL HEMORRHAGE.

requires notice, and it is, perhaps, the one most frequently
met with. It differs from the attacks just described, in the
important fact that it is unattended with unconsciousness.

Like the others, this species of cerebral haemorrhage may
take place very suddenly, without premonitory symptoms,
or it may, like them, happen while the patient is said to
be asleep. Generally, however, though there may be no
long prodromatic stage, there are symptoms occurring im-
mediately before the attack which indicate both mental and
physical disturbance. These are headache, vertigo, numb-
ness, vomiting, irritability of temper, and, perhaps, slight
difficulties of speech.

"When the attack comes, the individual, if standing, falls,
from the immediate paralysis of one leg. He is fully sen-
sible of his condition, although there is generally more or
less mental change. The arm and face are affected, and the
speech is rendered impossible or is indistinct.

If the patient be sitting or lying, he is aware that some-
thing has happened, but does not discover its exact charac-
ter till he attempts to rise. A distinguished general officer
of the army, after a fatiguing day of ceremony, entered his
carriage with his wife, to be driven to his hotel. As he
passed along Fifth Avenue, he felt an indescribable sensa-
tion, and immediately afterward noticed that he could only
see the half of objects. He made no effort to speak,
thouo;h he is confident he did not for a moment lose his
consciousness. "When he attempted to get out of the car-
riage, he found, to his surprise, that he was paralyzed on the
right side, and that his speech was so much impaired that
he could not be understood.

Another gentleman was reading an amusing book, at
which he laughed heartily. He felt suddenly a feeling of
vertigo, and the book dropped from his hand. He attempted
to pick it ap, but found he had lost power in the arm, and,
on trying to call to his wife, who was in the same room,
discovered that he could not speak. At this time he could

DISEASES OF THE BRAIN.

walk, but in a moment or two afterward he fell, from pa-
ralysis of his leg. So far as the paralysis is concerned, I
have rarely seen a more severe case than this.

Another went to bed, perfectly well, to all appearance,
having enjoyed miinterrupted good health for several years.
In the morning he arose, but felt a little pain in his head.
As he stood before his glass, he thought his face was slightly
twisted, and he noticed as he was shaving himself that he
did not feel the razor on one side. While he was testing
his facial mobility and sensibility, he experienced a trace
of numbness in his left hand. This gradually increased,
and in addition the limb lost power. In a few minutes he
could not move it at all. By the time I saw him — two hours
afterward — the paralysis had extended to the leg. At no
period was there insensibility or mental confusion.

A gentleman retired at night in good health. On at-
tempting to get out of bed he discovered that he was par-
alyzed in the leg. Keither the arm nor the face was af-
fected.

Several cases have been under my care in which only the
face or the tongue was paralyzed ; others in which the arm
alone was involved ; and others, like the one just mentioned,
in which the symptoms were confined entirely to the leg.
Sometimes there was a momentary feeling of vertigo, some-
times a vacant stare, something like that of the petit mat of
epilepsy, sometimes a slight degree of intellectual confusion,
sometimes headache, and, again, no head-symptoms whatever.
The subsequent progress of such attacks requires no special
consideration beyond that already given to the more severe
forms.

Now, no matter how light the attack may have been, nor
how rapid the improvement, the patient who has had cere-
bral haemorrhage is never mentally or physically the same
as he was before. If the seizure has been severe, he may
advance so far toward a complete cure as to evince very little
disorder of his mind or body. But close observation shows

CEREBRAL HEMORRHAGE.

that he is not entirely restored, and, tliough he may do
very well for light intellectual and physical exertion, se-
vere labor of either kind is beyond his powers — and no
one is more sensible of this fact than himself. Even after
years his emotions are abnormally excitable. A patient now
in the New York State Hospital for Diseases of the Nervous
System informs me that he sheds tears every time a funeral
passes him, and that even hearing of any one's death, or
reading the obituary column in a newspaper, causes his feel-
ings to get the better of him. In the lightest forms of the
attack, this easily-aroused emotional disturbance is a marked
feature for years subsequently, if it ever entirely disappears.
And as regards the muscles which have been paralyzed, it
is very certain that, though they maybe made strong enough
for all practical purposes, they never can be restored to their
former sound condition.

The character and general mental type of the individual
usually undergo some change ; and this may be ,to the ex-
tent of reversing his ordinary traits.

Causes. — Advanced age is one of the most influential cir-
cumstances which predispose to an attack of cerebral haem-
orrhage, and this fact has long been known. Thus Hip-
pocrates ' states that apoplexy is most common between the
ages of forty and sixty, and modern investigation estab-
lishes the truth of the proposition as regards the actual
number of cases. It is probable, however, that the liability
increases, as Dr. Flint ' says, from the age of twenty uj)-
ward, and that there are not so many cases occurring in per-
sons over sixty as below, for the reason that the number of
individuals alive of that age is less.

Of two hundred and twenty-nine cases of cerebral haem-
orrhage which have been under my professional care during
the last five years, two hundred and four occurred in persons

^ Aphorisms, chapter vi., aph. 57.

A Treatise on the Principles and Practice of Medicine." Third edition.
Philadelphia, 1868, page 582.

DISEASES OF THE BRAIN.

over forty years of age. Of tliese, one hundred and seventy-
two were between forty and sixty, twenty-four between
sixty and seventy, five between seventy and eiglity, and
three over eighty.

Of the twenty-five cases in persons under forty, seven-
teen were between forty and thirty, seven between thirty
and twenty, and one under twenty. This latter was a boy
of seventeen, whom I exhibited at my clinic at the Bellevue
Hospital Medical College in the autumn of 1870.

The disease is certainly more common among men than
women, though some authors have asserted the contrary.
Falret ascertained that, of twenty-two hundred and ninety-
seven cases, sixteen hundred and sixty occurred in males and
only six hundred and thirty-seven in females. In my own
experience, of two hundred and twenty-nine cases, one hun-
dred and fifty-three were in males and seventy-six in fe-
males.

Temperament and organization are supposed to have an
influence in predisposing to cerebral haemorrhage. It was
formerly thought that those of sanguine temperament and
plethoric habit who had stout bodies, large heads, florid
complexions, and short, thick necks, were especially liable ;
but more- exact and thorough investigation would appear to
show that such is not the case, and that thin and pale indi-
viduals show fully as great a proclivity. Dr. Flint ^ ex-
presses the opinion that there is no special apoplectic consti-
tution, and my own experience is decidedly to the same
effect.

That the tendency to cerebral haemorrhage is often heredi-
tary, appears to be very certainly established. Within my
own knowledge, I am aware of several striking instances
which support this opinion. A gentleman consulted me
for hemiplegia, the result of cerebral haemorrhage, whose
grandfather, father, two uncles, two brothers, and one sister,
had died of this disease, and whose son, thirty-six years of

Op. cit., p. 583.

CEREBRAL HEMORRHAGE.

age, had been attacked. In another case a lady had her
father, two brothers, and one sister, die of the disease ; and, in
a third very remarkable case, the great-grandfather, grand-
mother, father, four uncles and aunts, and two brothers, all
in a direct line, died of cerebral hseraorrhage.

Piorry * cites the case of a woman, herself paralytic,
whose three children had died of convulsions, and whose
mother, uncle, and brothers and sisters, to the number of
twelve, had died of cerebral hsemorrhage or convulsions. It
has very often happened in my experience that the father
or mother of a hemiplegic patient, whose condition resulted
from cerebral haemorrhage, had been aifected in a similar
manner.

As regards the influence of diseases of the heart, Legal-
lois, Brichteau, Rostan, Andral, and Bouillaud,' adduce in-
stances in support of the existence of a definite relation.
"While others, among whom Rochoux, Walshe, and Flint are
to be placed, deny the existence of any causative influence.
As tending to produce active or passive cerebral congestion,
disease of the left or right side of the heart would reasonably
seem to be conducive to the occurrence of cerebral haemor-
rhage. The tension of the blood in the vessels of the brain
is increased thereby, and the liability to the rupture of a dis-
eased vessel rendered greater.

The condition of life has also been supposed to exert an
effect in predisposing to cerebral haemorrhage, it being as-
serted by some authors that the affection is much more
common with the rich, and those living in ease, luxury, and
refinement, than in the poor and laboring classes.

It is difficult to arrive at any very definite conclusion on
this point, owing to very obvious reasons, but I am inclined
to think the theory to be not well founded. It is only ne-
cessary to visit our large hospitals, to see how many of the
inmates, drawn as they generally are from the laboring

' De I'Heredite dans les Maladies, p. 107.

* Traite de Clinique des Maladies du Cceur. 2d edi., t. ii., p. 580

DISEASES OF THE BRAIN.

classes, are suffering from cerebral htemorrhage or its ef-
fects.

Thus far we have only considered the more important,
intrinsic, predisposing causes; there are, however, others
which may be called extrinsic.

Season is one of the chief of these. The disease is much
more common in winter than in the other seasons, although
some statistics would seem to show more cases during sum-
mer. A careful examination of such, however, shows that
under the head of apoplexy are iucluded not only cerebral
hsemorrhage, but congestion, sunstroke, embolus, and in
fact nearly every other affection attended with sudden loss
of consciousness. My own researches have been very exact
on this point, and as their results I find that, of the two hun-
dred and twenty -nine cases of which I have notes, eighty-
five occurred in winter, forty-one in spring, fifty-six in sum-
mer, and forty-seven in autumn. It has been noticed, too,
that sudden variations of temperature, especially from mild
to cold weather, increase the number of cases of cerebral
hsemorrhage. •

Of the exciting causes, a long list can readily be made.
Among them are the excessive use of alcoholic liquors and
other stimulating substances, the use of opium in excess ; the
ingestion of large quantities of food, especially such as is
stimulating and indigestible; excessive physical or mental
exertion, strong emotional disturbance, such as anxiety, ex-
treme joy, anger or terror ; the act of coition, especially in
old people ; straining at stool ; enlarged prostate, or paralysis
of the bladder, requiring strong muscular efforts for the evac-
uation of the urine ; childbirth ; tight clothing about the
neck, chest, or abdomen ; certain occupations which require
the head to be depressed ; vomiting, sneezing, coughing, and
laughing ; exposure to the direct rays of the sun or other
sources of great heat ; the sudden arrest of a customary flux,
such as hsemorrhoidal bleeding ; the sudden application of
cold water to the body; long-continued bathing in very

CEREBRAL HEMORRHAGE.

warm water ; the circumstance that the patient has had a
previous attack, and certain diseases, as gout and syphilis.

In regard to some of these causes, I may state that sev-
eral very interesting cases have occurred in my own prac-
tice. In one, a lady was attacked on hearing that her cook
had left her, in another tlie emotion excited by the fall of a
picture from the wall caused a seizure. Four cases pro-
duced by straining at stool have come under my observation.
In one of them a gentleman well known in public life re-
tained sufficient consciousness and intelligence to take a
large key out of his pocket with the non-paralyzed hand, and
to rap on the floor for assistance.

Two cases occurred during sexual intercourse, one in a
man, the other in a woman. In one of these there was, sub-
sequently, a great increase of venereal desire. In one case,
the seizure was induced by stooping over to tie the shoe.
This was in the boy, seventeen years of age, already men-
tioned. It must be confessed, however, that very frequently,
perhaps in the majority of cases, no immediate cause can be
reasonably alleged. Of the two hundred and twentjMiine
cases noted by myself, no cause was noted in one hundred
and fifty-three.

Relative to the influence of sleep, I am by no means in
accord with those authors who regard it as a powerful, ex-
citing cause. During sleep the quantity of blood circulating'
in the cerebral blood-vessels is diminished, and hence there
is less tension upon their walls than during wakefulness.
I doubt very much whether cerebral haemorrhage ever oc-
curs during healthy, undisturbed sleep.

But there is a condition which supervenes uj)on sleep, and
which, to ordinary observers, presents the usual phenomena
of sleep, but which is really a very difierent state, both as re-
gards the brain and the symptoms — and that is stupor due
to venous congestion. In this affection there is an increase
of the pressure upon the brain, produced by the over-dis-
tended vessels; and hence coma, to some extent, ensues.

DISEASES OF THE BRAIN.

This state is characterized by diflaculty of awaking the indi-
vidual, by turgescence of the larger veins of the neck, by a
more or less purple hue of the face, by snoring, and by the
puffing out of the lips and cheeks in breathing. Both of
these latter phenomena are due to paralysis.

In this condition it is not unusual for cerebral haemor-
rhage to occur, but the existing state is not sleep.

So far as my own experience extends, I have not found
a majority of the cases, where I have examined into this
point, to have taken place either during sleep or the stupor
to which I have referred. I have made it a rule, not only
in those cases of cerebral haemorrhage which have been
under my own care, but all others, in which I could do so,
to inquire particularly with reference to the matter in ques-
tion, and have found that, in two hundred and fifty-five
out of three hundred and forty-two cases, the individuals
were awake at the time of the attack.

Doubtless much of the confusion has arisen, not only
from the non-discrimination of sleep with stupor, but also
from treating of apoplexy as a disease instead of regard-
ing it as a symptom due to several very different pathological
conditions of which cerebral haemorrhage is only one, and
of which embolism, thrombosis, congestion, meningeal haem-
orrhage, and epilej)sy, are others.

Finally, it may be said of the etiology, that whatever
tends to increase the flow of blood to the head, or to retard
its exit, is capable of acting as an immediate cause of cere-
bral haemorrhage.

Diagnosis.— The diagnosis of cerebral haemorrhage is or-
dinarily not difficult, but it must be confessed that one or
two affections are very liable to be confounded with it, and
the attendant circumstances surrounding a patient in a con-
dition of insensibility may be such as to materially increase
the obstacles to the formation of a correct opinion.

Thus, supposing an individual to be found in a state of
profound insensibility, the condition may be due to compres-

CEREBRAL HEMORRHAGE.

sion from injury of the skull, to concussion from a fall
or blow, to congestion, to asphyxia, to syncope, to a recent
epileptic fit, to ursemic intoxication, to hysteria, to narco-
tism, or to drunkenness.

A mistake of either of these states for cerebral haemor-
rhage would be, in the end, embarrassing to the physician,
and, perhaps, injiirious to the patient.

The coma miglit also be the result of embolism, of throm-
bosis, of tumor, of abscess, or of meningeal hijemorrhage; but,
as regards these conditions, no opprobrium could be attached
to the physician, or harm come to the patient, by any error
of diagnosis, although a regard for scientific exactness should
always prompt us to be as specific as possible in our in-
quiries and examinations.

From asphyxia, cerebral haemorrhage is distinguished
by the fact that in the former the respiration is suspended.
The cause is also often apparent. A careful examination
of the cranium, and a survey of the surrounding circum-
stances, will enable the physician to ascertain the existence
or non-existence of compression from traumatic cause.
This cause may either be depression of bone, the rupture
of an internal blood-vessel, or the entrance of some foreign
body, as a bullet, into the interior of the skull. So far as
symptoms are concerned, there might be considerable diffi-
culty in diagnosticating either of these accidents from cere-
bral haemorrhage, but the history would render a mistake
impossible.

Concussion presents more difficulties, because the coma-
tose person may be found in such a situation as to warrant
the opinion that he has fallen from a height, or otherwise
received a blow on the head, when in fact he is sufiiering
from cerebral haemorrhage. But if he has fallen from a
height or been struck, there will probably be more severe
bruises about his ^^erson than if he is afiected with cerebral
haemorrhage, and there may be bleeding from the ears or
nose — symptoms of cranial injury not met with in the latter
condition.

DISEASES OF THE BRAIN.

If, liowever, the individual lias fallen from a lieiglit, he
may have done so in consequence of an extravasation of
blood in his brain, and he may' present all the marks of suf-
fering simply from the concussion, or he may have fractured
skull with compression. It is, therefore, impossible to make
a correct diagnosis in all cases, or to lay down any certain
rules which will constitute infallible guides. It is perfectly
possible to meet with cases such as those referred to, in re-
gard to which no human judgment can be certainly correct.
Such instances are of course rare, and accordingly, in the
great majority, the circumstances and the presumption will
generally lead to a correct opinion.

From congestion of the apoplectiform variety cerebral
haemorrhage can generally be distinguished without much
'difficulty. The absence of stertorous breathing, the short
duration of the coma, the transient character of the paraly-
sis, the contraction of the pupils, the fact that the loss of
sensibility and. the power of motion are not generally con-
fined to one side of the body, and the longer continuance
of premonitory symptoms, will be sufficient indications of
the existence of congestion. Syncope is distinguished by
the circumstances that the respiration and circulation are
both diminished in power if not suspended, that there is no
hemiplegia, that the face is pale, the skin cold, and that these
phenomena are all transitory in character. The history of
the case will also assist us in arriving at a correct judgment.

Epilepsy, if seen from the beginning of the paroxysm,
cannot be mistaken for cerebral haemorrhage, nor this latter
for epilepsy, if the onset of the attack has been witnessed.
But a person found in a comatose condition, with no previ-
ous history to guide us, may be supposed to be either in the
comatose stage of an epileptic paroxysm, or to be laboring
under a seizure due to extravasation of blood. In such
a case, if the fit has been epileptic, foam will be found
around the mouth, and perhaps blood from injury of the
tongue or cheek. Moreover, the stupor of epilepsy is not

CEREBRAL HAEMORRHAGE.

usually of long duration, and is not generally characterized
by stertorous breathing.

In uraemia, the coma of which is very similar to that
resulting from cerebral haemorrhage, the liistory of the case
is our chief reliance for a correct diagnosis, though the ab-
sence of hemiplegia and the general presence of anasarca
are of course of great value. Moreover, in very doubtful
cases the urine may be drawn off by the catheter, and exam-
ined for albumen and tube-casts. If these are present, the
probability of the stupor being due to Bright's disease and
nrsemic intoxication is very much increased.

Coma is sometimes a manifestation of hysteria, but a
very little acquaintance with the phenomena of this condi-
tion will suffice to prevent mistakes. In some cases of hys-
terical coma there is well-marked hemiplegia ; but even
when this complication is present, the facts that the hyster-
ical diathesis exists, that there have probably been other
manifestations of hysteria, that the pulse is small, weak, and
frequent, and that the breathing is free from stertor, will
enable a correct diagnosis to be formed.

In narcotism the condition often bears a close resem-
blance to that due to cerebral h£emorrhage. But in the
former there is no hemiplegia, the pupils are generally con-
tracted, the respiration is not stertorous, and the coma comes
on gradually.

Drunkenness and cerebral haemorrhage are often con-
founded. I have known some sad mistakes of the kind to
be made, both by professional and non-professional persons,
many of which were unavoidable, for it must be confessed
that there are great difficulties connected with the subject.
The habit of drinking alcoholic liquors is so general that no
reliance can be placed upon the test of smelling the breath.
A person may have just taken a glass of wine or of brandy,
and be seized with extravasation of blood in his brain im-
mediately afterward, and when not in the least intoxicated.
And, even if dead-drunk, he may at the same time have

•DISEASES OF THE BRAIN.

cerebral haemorrhage. In such a case as the latter, discrimi-
nation would be impossible. In ordinary cases of alcoholic
intoxication the patient can generally be roused to some
extent ; the pupils are dilated, but this latter is often the
case in hsjemorrhage ; the breathing is usually free from
stertor, but some drunkards always snore ; the pulse is
small and weak, and there is no hemiplegia. When all
these symptoms are in accord, there will be little difficulty ;
when they are not, the physician must be guarded in his
expressions of opinion, and diligently inquire into the per-
sonal characteristics of the patient and all matters bearing
on the history of the case.

From the centric diseases previously mentioned, the
diagnosis of cerebral haemorrhage is easy as regards some,
and difficult as to others. Thus, from embolism it cannot
in many cases be distinguished in the first stage. But when
all the phenomena are taken into consideration the chance
of error is very much diminished. Embolism is generally
accompanied with disease of the left side of the heart, and
there is often a history of rheumatism ; there are never any
premonitory head-symptoms ; it occurs in young persons as
well as old ; for reasons which will be explained when the
subject of partial cerebral anaemia from embolism is consid-
ered, the resulting hemiplegia is generally on the right side ;
the paralysis generally disappears in a few hours after the
attack ; if it does not, there is no gradual improvement, as
in cerebral haemorrhage ; there are no contractions or partial
convulsions,^ and there is more frequently delirium.

The gradual development of the symptoms in thrombosis,
tumor, or abscess, and the frequency with which convul-
sions ensue in the latter diseases, together with the asso-
ciated symptoms, will prevent the coma which sometimes
exists being mistaken for the stupor of cerebral haemorrhage.

' Jaccoud (op. cit., p. 141) so asserts, though I have seen one case in which
post-mortem examination revealed the presence of an embolus in the middle
cerebral artery, and in which there had been convulsions.

CEREBRAL HEMORRHAGE.

During the subsequent stages of cerebral haemorrhage,
when the mental condition and the hemiplegia are the most
prominent features, inquiry into the antecedent history will
bring out the foregoing points, and assist us in arriving
at a correct idea of the cause. Even, however, should we
be baffled in this respect, no great inconvenience could re-
sult either to the patient or physician.

Prognosis. — The prognosis depends upon the extent of the
haemorrhage, and refers to the probability of saving life
during the period of attack and immediately afterward, and
of curing or mitigating the subsequent paralysis.

In the severe apoplectic form, death is almost inevitable ;
so far as my experience goes, it is the invariable result. It
generally takes place within a few hours. If, however,
life be prolonged till the fourth day, there is some hope.
Irregularity of pulse, or one very rapid, impossibility of
swallowing, involuntary evacuation of the faeces, and cold
sweats, render, if possible, the prognosis still more unfavor-
able.

In the apoplectic form attended with paralysis, the grad-
ual increase of the coma and hemiplegia indicate the con-
tinuance of the haemorrhage, and are consequently of grave
importance. About one-third of those attacked with this
form die. The prognosis is bad in accordance with the
strength and age of the patient, and the circumstances under
which the attack has occurred. Thus, if it has supervened
in a person who has had no obvious exciting cause, the
probability is that there is serious disease of the blood-ves-
sels, whereas, coming on in a young person as the result of
severe muscular exercise, or mental strain, the prognosis is
more favorable. A second attack is more apt to prove fatal
than a first, and a third than a second, and so on.

In the mild form characterized by paralysis, but no
loss of consciousness, the prognosis is generally favorable.
It must be recollected, however, that the risk of inflamma-
tion is quite great, both in this and the apoplectic form with

DISEASES OF THE BRAIN.

paralysis, and that the patient is not safe from it till after
the eighth day.

And in both forms, if the temperature rise above 100°
Fahr., if the respiration be chiefly abdominal, and rattling
of mucus is heard in the throat, the prospect of recovery is
bad. The same may be said of pain in the head and con-
tractions of the paralyzed muscles.

As regards tlie probability of recovery from the paraly-
sis, much depends upon the opportunities the patient may
have for receiving proper medical treatment. The ten-
dency is generally toward amendment even in the worst
cases. Gradually the speech improves, the breathing be-
comes better, and the arm acquires more strength ; but the
improvement often stops now, and never goes on unaided to
complete recovery. The longer the paralysis has lasted, the
less prospect there is of great progress under any treatment,
and, if strong contractions producing distortions have taken
place, the prognosis is unfavorable.

Certain muscles recover better than others. The exten-
sors of the foot and hand are especially intractable, but, as
a rule, those of the lower extremity improve more rapidly
than those of the upper.

The mind ordinarily imipYoye&, pari passu with the phys-
ical symptoms, though not always. I have witnessed several
exceptions to the rule. Even in slight cases the intellect
may suffer to a great extent, and in no case is it ever in all
respects as good as before the attack. Among the unfavor-
able signs are persistent iritability of temper, failure of
memory, and the existence of delusions. Difficulties of
speech, whether as. regards the memory of words, or the
ability to coordinate the muscles of speech so as to pro-
nounce them properly, are often very persistent. I have
now under my care a gentleman who was attacked with
cerebral haemorrhage two years ago, whose physical pow-
ers are quite good, and whose mind is not seriously im-
paired, but who cannot yet remember sufficient words to

CEREBRAL HEMORRHAGE.

carry on an ordinary conversation. "When the difficulty is
simply due to paralysis of the tongue and facial muscles,
the prognosis is more favorable.

Morbid Anatomy. — The seat of the extravasation from
cerebral haemorrhage may be in the substance of the cerebral
tissue, or in the ventricles. The former is much the more
common.

ISTow, the blood which is poured out from a ruptured ves-
sel into the substance of the brain must, of course, occupy
its place by separating or lacerating the fibres. It thus
forms for itself a cavity which enlarges as the haemorrhage
goes on, until at last the resistance to further separation or
laceration may be so great as to overcome the tension of the
blood, and thus put a stop to the bleeding.

The shape of the cavity varies according to the manner
by which it has been produced. "When it is formed by the
separation of the cerebral fibres, it is generally elongated ;
whereas, when produced by laceration, it is oval, round, or
irregular in form. The situation of the haemorrhage modi-
fies the form of the cavity. In the hemisphere it is usually
round, in the motor tract irregular or oval. The variations
as regards size are great. I have seen clots no larger than
a pea, and again as large as an orange. When haemorrhage
occurs in the motor tract, the clot is almost invariably small ;
whereas, in the hemispheres, in the cerebellum, or in the
ventricles, it is large.

A clot does not always consist of blood alone. Brain-
tissue is very often mixed with it, and this is especially the
case when the extravasation has been in the hemispheres.

The ordinary seat of cerebral haemorrhage is the motor
tract, and especially the corpus striatum and optic thalamus.
The cms cerebri may also be the seat of the extravasation,
though not often primarily.

When the haemorrhage occurs in the mesial line of the
pons varolii, the paralysis is, of course, on both sides of the
body. Two cases of the kind have occurred in my practice,
7

DISEASES OF THE BRAIN.

and both were from severe blows on the skull. One side
of the pons is more frequently the seat.

The medulla oblongata is not often involved, though a
few cases are on record.

The hemispheres and the lateral ventricles are occasion-
ally the seats of extravasation, the cerebellum rarely.

Extravasated blood undergoes certain changes. Instead
of separating into two parts, the clot and the serum, as does
blood when exposed to the atmosphere, it remains for a time
homogeneous and gelatiniform. About the fifth or sixth
day it separates into two parts : the one, the serum, is ab-
sorbed by the surrounding tissue ; the other, consisting
mainly of the fibrine and the red corpuscles, contracts and
becomes hard. By the fifteenth day it has become fibrinous
in texture, and is changed from its former black hue to a
yellow color. Microscopic examination, made at any period
during these changes, reveals the presence of red corpuscles,
crystals of hematoidin and sometimes of cholestrin. It
never entirely disappears.

In the early period of the extravasation, the walls of the
cavity are rough, and discolored with blood. But, as the
changes are going on in the clot, the walls likewise alter in
appearance ; the inequalities and irregularities disappear,
and a new formation of connective tissue lines the cavity.
Blood-vessels appear in it, and aid in the absorption of the
fluid portion of the extravasated blood. As the process of
separation and absorption goes on, the cavity contracts upon
its contents, and eventually forms a cicatrix which encloses
the remains of the clot. This cicatrix is generally of a yel-
low color, and firm in texture.

Sometimes, however, absorption does not take place.
The contraction of the walls of the cavity does not there-
fore ensue, and it remains distended with more or less al-
tered blood. This may be the starting-point of secondary
lesions, or a new haemorrhage may occur into the same cav-
ity, or an abscess may result.

CEREBRAL HAEMORRHAGE.

Pathology. — The theory of cerebral haemorrhage brings
us to the consideration of several important points. One
of the first questions to be solved is, Can the rupture of a
vessel of the brain take place — not including traumatic
causes — unless the vessel is in a diseased condition ? Both
sides of this proposition have their adherents. On the one
part, it is urged that cerebral haemorrhage never takes
place spontaneously unless the walls of the bleeding vessel
have been so injured by disease as to destroy their strength
and elasticity ; on the other, that it is perfectly possible for
a blood-vessel to give way, owing to increased tension of the
blood or disease of the perivascular tissue, without the walls
of the vessel itself being in the least diseased. "While ad-
mitting that, in the majority of cases, the structure of the
yielding vessel will be found to be impaired, I am satisfied
that either of the other two causes may produce a rupture.
The reasons for this opinion will be apparent in the course
of the following remarks.

The most common disease to which the cerebral arteries
are liable is chronic endarteritis, a condition which has been
well described by Yirchow,* and which is particularly apt to
be met with in those who, from age or other debilitating
influence, have had their nutrition impaired. As the con-
sequence of this state, the vessels lose their elasticity, be-
come brittle, and are therefore often unable to bear the ordi-
nary tension of the blood, much less any severe strain. This
disease may terminate in fatty degeneration of the arterial
walls, or this last condition may be the primary affection .
Fatty degeneration, like chronic endarteritis, is most com-
monly met with in badly-nourished persons, but who are at
the same time cachectic. The inner coat is the point of
origin, and hence it sometimes happens that this and the
middle coat give way, leaving the external coat entire, and

' Ueber die Erweiterung kleinerer Gefasse. Archiv fiir Path. Anat. und Phy»
siol, B. III., 1848, and Cellular Pathology, London, 1860, Lecture XVI.

100

DISEASES OF THE BRAIN

thus forming an aneurism. But Bouchard/ wlio has exam-
ined into this matter with great minuteness, denies that
such aneurisms are ever found, and asserts that the so-called
aneurismal sac consists of the lymphatic membrane, lining
the cavity in the perivascular tissue, through which the ves-
sel passes, and that the blood, in such cases, has already
ruptured the vessel. In reality, however, there is no
haemorrhage into the cerebral tissue till this membrane gives
way.

In a subsequent memoir, by MM. Charcot and Bouchard,'
this point is still more thoroughly considered, and the opin-
ion expressed that cerebral haemorrhage is almost invariably
due to these so-called miliary aneurisms, which are the
result of arteritis, and which are not necessarily preceded by
atheroma.

In sixty-nine cases of cerebral haemorrhage in which
post-mortem examinations were made, atheroma was found
but in fifteen, or twenty-two per cent., while these miliary
aneurisms were met with in every case. They appear as
little globular masses in the small intracranial vessels, and
are in size from one-tenth of a millimetre to one millimetre.
If they contain liquid blood, they are red ; but, if the blood
be coagulated, the color is dark, almost black in some cases.
In the order of frequency, they are found in the optic thala-
mi, the corpora striata, the convolutions, the tuber annulare,
the cerebellum, the centrum ovale, the crura cerebri, and
the medulla oblongata.

The condition of the perivascular tissue, or the brain-
substance, has much to do with the occurrence of haemor-
rhage. One reason why extravasation more frequently oc-
curs in the brain than in the liver, for instance, is that its
tissue is softer, and therefore not capable of giving as much

1 Etudes sur quelques Pointes de la Pathogenie des Hemorrhagies cerebrales.
Paris, 1866.

^ Nouvelles Recherches sur la Pathogenie de I'Hemorrhage cerebrale. Ar-
chives de Physiologie Normale et Pathologique, 1868, pp. 110-643.

CEREBRAL HEMORRHAGE.

101

support to the blood-vessels as is the latter organ. Now,
when the cerebral substance is softened by disease in any
part, the natural support of the vessels of that part is still
further lessened, and the tendency to haemorrhage increased.
Again, in the condition sometimes met with in old people,
in which the brain becomes atrophied, the vessels may
undergo dilatation and subsequent rupture. This view is
opposed by Jaccoud,' but in one case of cerebral haemor-
rhage, terminating in death, and in which I had the oppor-
tunity of making a post-mortem examination, the right
hemisphere, the seat of the extravasation, was very consid-
erably atrophied, and weighed three ounces and a quarter
less than the left. The possibility of the existence of this
cause may, therefore, be admitted, although it cannot be
considered as definitely established. The researches of Co-
tard ' would appear to show that cerebral haemorrhage is
not infrequently a cause of partial atrophy of the brain.

In the next place, the state of the blood, as regards qual-
ity and tension, must be considered. There can be no doubt
that certain diseases affecting the general system may so
deteriorate the blood as to render it unfit to properly nour-
ish the blood-vessels, and hence their tissue is more readily
broken down. Among these conditions are typhus, scurvy,
chlorosis, and syphilis.

The tension of the blood in the vessels is subject to con-
stant variation from the operation of many physical and
mental causes, and may, through their action, be so in-
creased as to overcome the resistance afforded by the vascular
walls. These influences have been sufiiciently considered
in the section on causes, and need not, therefore, be dwelt
upon here at any length. My own opinion of their suffi-
ciency, without preexisting disease of the blood-vessels, to
produce rupture and extravasation, has been formed after
much observation and reflection. Analogous phenomena

J Op. cit., p. 155.

2 Etude sur I'Atrophie partielle du Cerveau, Paris, 1868.

102

DISEASES OF THE BRAIN.

take place every day, and are not supposed to be due, in
any extent, to vascular disease. Thus nasal lisemorrliage
occurs from strong muscular exertion of sucli a character as
to retard the flow of blood from the brain, from emotional or
other kind of mental excitement, and from hypertrophy of
the left side of the heart, by which the amount of blood iu
the cerebral vessels is increased. All these causes augment
the tension, and it would be singular if at times a healthy
intracranial vessel did not give way through their influence
as well as one outside of the skull.

A point of very great importance remains to be con-
sidered as a part of the pathology, and that is whether it is
possible or not to determine during life in what part of the
brain an extravasation has taken place ? While I am afraid
we cannot be as explicit in this matter as is desirable, I am
very sure we can often, from a careful study of the symp-
toms, arrive at conclusions more or less accurate, and can
sometimes determine the question with absolute certainty.
The great difficulty is, that we are not yet sufficiently ac-
quainted with the physiology of the several parts of the
brain, and hence are not able to ascribe, with as mucb sure-
ness as is desirable, variations from healthy action to de-
rangement of the proper anatomical part of the cerebral
mass.

As we have seen, haemorrhage is more liable to take place
within the ganglia constituting the motor tract than any
other part of the brain. This is mainly due to the fact that
this is the most vascular part of the cerebral substance.

"When the lesion is limited to the corpus striatum of one
side, there is loss of the power of voluntary motion on the
opposite side, but no abolition of sensibility, except, per-
haps, for a few hours. Cases in illustration of this fact have
been given by Andral ' and Luj^s,' and one instance in my
own experience was established by post-mortem examina-

* Clinique Medicale, t. v., pp. 319-321, 442.

* Recherches sur le Syst^me Nerveux C6rebro-Spinal, etc., p. 545.

CEREBRAL HAEMORRHAGE.

103

tion. The patient, a man sixty-two years of age, had been
hemiplegic for eleven years, and died suddenly, in April,
1851. Post-mortem examination showed the cause of death
to have been fatty degeneration of the heart. On examin-
ing the brain, a cicatrix was discovered in the right corpus
striatum. The hemiplegia was on the left side, and had
never been accompanied with any loss of sensibility. There
was no other lesion of the brain, so far as could be ascer-
tained.

The optic thalamus is another common seat of extrava-
sation. In such a case the observed symptoms are especial-
ly connected with the organs of the special senses. Thus
there are double vision, dilatation or convulsive movements
of the pupil, blindness, and anaesthesia or hypersesthesia
of the paralyzed parts of the body. As in lesion of the cor-
pus striatum, the paralysis of motion, when it exists, is on
the opposite side of the body. The hearing and smell may
also be affected. Luys ' has collected a large number of
cases in support of the view here enunciated.

It generally happens that an extravasation, originating
in either the corpus striatum or optic thalamus, involves
both these ganglia. Hence we have, as the most common
symptoms of cerebral haemorrhage, loss or impairment of
the power of motion, disturbance of sensibility, dilatation or
irregular movements of the pupil, aberrations of vision, etc.

When the extravasation beginning in the left optic thala-
mus or corpus striatum extends to the fissure of Sylvius so as
to involve the posterior part of the third frontal convolution,
the island of Eeil, or other part supplied by the middle cere-
bral artery, or when it originates in this region, aberrations
of speech occur. These are independent of paralysis of the
tongue, and are such as are embraced under the term
aphasia. This subject will be hereafter more fully con-
sidered.

Haemorrhage into the crus cerebri produces hemiplegia
' Op. cit., p. 534, et seq.

104

DISEASES OF THE BRAIN.

of the opposite side, more or less extensive, according to the
size of the clot, with loss of sensibility. The third pair
arises in part from the crus, and hence may be paralyzed,
producing ptosis and external strabismus on the side corre-
sponding to the seat of the lesion, and consequently opposite
to the hemiplegia.

When the pons varolii is affected, the crossed paralysis
is still more marked. The limbs are paralyzed on the oppo-
site side, and the face in whole or in part on the same side
as that in which the haemorrhage takes j)lace. If the ex-
travasation is in the mesial line, both sides of the body are
paralyzed. According to Trousseau,' however, crossed paral-
ysis is not always due to a lesion of the pons, as asserted by
Gubler," and as supported by additional cases collected by
Luys." Trousseau rests his opinion on one case in which
after death very extensive lesions of the brain were found,
but none involving the pons.

The principal symptoms indicating the medulla oblongata
as the seat of extravasation are, loss of the power of swal-
lowing, from paralysis of the glosso-pharyngeal, difficulty of
protruding the tongue, from paralysis of the hypoglossal, and
huskiness of the voice, tumultuous action of the heart, dysp-
noea and gastric derangements, from paralysis of the pneu-
mogastric nerve.

In lesions strictly limited to the ganglia cited, there is
no aberration of the intellectual faculties. It is only when
the gray substance of the cerebrum or cerebellum is involved
that the mind participates. In those cases of cerebral haem-
orrhage, therefore, attended with coma or other mental phe-
nomena, we may be very sure that the gray substance of the
organs mentioned is affected, and this may be either from
the haemorrhage which has originated in the motor tract

' Lectures on Clinical Medicine, Bazire's Translation, part ii., p. 333.
» Sur I'Hemiplegie Alterne, Gaz. Hebd., October, 1856, and Memoirs sur les
Paralysies Altemes, etc., Gaz. Hebd., 1859.
3 Op. cit, p. 529, et seq.

CEREBRAL HAEMORRHAGE.

105

being so extensive as to compress the cerebrum or cerebel-
lum, or from an extravasation beginning in the first place in
these ganglia. The researches I have made * relative to the
functions of the cerebellum would seem to show that its
office is not materially different from that of the cerebrum.
Still, I think there are some indications which, although
not perhaps giving us the right to form a definite conclu-
sion, are jet sufficiently well marked to enable us to arrive
at a probable diagnosis between lioemorrhagic lesion of the
cerebrum and that of the cerebellum. Thus, vertigo is almost
an invariable accompaniment of the cerebellar extravasa-
tion ; vomiting is much more generally met with than when
the cerebrum is affected ; hemiplegia is not so common ; the
sensibility is never disturbed ; and the pain is in the back
of the head.

Besides a number of cases, some of which are referred
to in the memoirs cited, one has occurred in my experience,
in which I had the opportunity of making a post-mortem
examination."

A man had suffered from vertigo, occasional convulsions,
attacks of nausea and vomiting, and a constant and violent
pain affecting the back of the head. The symptoms had
ensued in consequence of a severe blow which he had re-
ceived on the back of the head by raising himself too soon
while the horse he was riding was passing under a low arch-
way.

When this man attempted to walk he reeled and stag-
gered as if he were drunk. The upper extremities and the
organs of speech were not affected ; he had the entire con-
trol of his legs when lying down, and there was no diminu-
tion of sensibility anywhere. At last he became paraplegic,
and shortly afterward died in a convulsion. The post-mor-
tem examination showed the existence of an abscess which

* The Physiology and Pathology of the Cerebellum. Quarterly Journal of
Psychological Medicine, April, 1869.
2 Op. cit., p. 209.

106

DISEASES OF THE BRAIN.

had obliterated nearly the whole of the left lobe of the cere-
bellum. The other parts of the brain were, so far as could
be perceived, perfectly healthy.

Extensive haemorrhage may take place in the white sub-
stance of the cerebrum, and little disturbance of either mo-
tion or sensibility result. It usually happens, however, that
the extravasation makes its way to the motor tract, and then
the symptoms due to lesion of this part of the brain make
their appearance. Besides the occurrence of local second-
ary lesions, the immediate result of the presence of a foreign
body in the cerebral tissue, there are others, which are due
to the interruption of the normal brain-functions, which
haemorrhage so generally induces. Thus, atrophy of the
cerebral structure may result, as has been pointed out by
Cotard ' and others, or the degeneration may extend to the
spinal cord, as so well shown by Bouchard." In this latter
event the process does not begin till about the end of the
fourth or fifth month.

Treatment. — The means of treatment in cerebral haemor-
rhage are, first, those which are applicable to the prodro-
matic stage, with a view of preventing any lesion ; second,
those proper daring the seizure ; and, third, those which are
to be directed against the consequences of an attack.

It often happens that an attack may be prevented, even
where the threatenings are very decided. The condition of
the brain is such that the indications are to lessen the ten-
sion of the blood as much as possible. As I have already
remarked, under the head of cerebral congestion, the bro-
mides of potassium and sodium are peculiarly efiicacious in
accomplishing this end. Lately, in consequence of the in-
vestigations of Dr. S. Weir Mitchell, of Philadelphia, I have
made much use of the bromide of lithium in cerebral con-
gestion with or without a tendency to haemorrhage, and

' Etude sur 1' Atrophic Partielle du Cerveau, Paris, 1868.
* Des Degenerations Secondaires de la Moelle ^pmiSre, Archiv. Gen. do
Medecine, 1866. Also, Hun's translation, American Journal of Insanity, 1869.

CEREBRAL HEMORRHAGE.

107

liave had reason to prefer it to either the potassium or
sodium salt. One feature of its action, which renders it
especially useful in such cases as those now under notice, is
the short interval which elapses between its administration
and the effect. I am very sure I have given it successfully
in several cases in which the other bromides would not have
acted so happily. In one of these, a gentleman from the
South, who had already had an attack, and who was in con-
sequence hemiplegic, was relieved of his vertigo, headache,
numbness, and thickness of speech, by one dose of thirty
grains, in less than half an hour. The oxide of zinc may
also be given with advantage.

The bowels, if costive, should be opened by a brisk
purgative ; the stomach, if overloaded, should be emptied
by an emetic, during the action of which warm water should
be freely drunk so as to avoid, as far as possible, all strain-
ing ; muscular exertion should be avoided, the head should
be kept cool and well elevated, and the mind in a state of
the utmost tranquillity.

During an attack, and throughout the whole period of
reparation of damages, the less that is done in the vast ma-
jority of cases the better. The question of the propriety of
bloodletting will generally even yet arise, but should in
nearly every case be decided in the negative. I say nearly,
for I know of but one possible form of attack in which it
can by any possibility not only not be useful, but fail to
do harm ; and that is in a strong, plethoric person, with a
full, bounding pulse, in whom, from the gradual develop-
ment of the symptoms, we have reason to suspect that the
haemorrhage is still going on. In such a case, six or eight
ounces of blood may be taken from the arm. But in a case
of cerebral hsemorrhage attended by coma and the ordinary
symptoms of the apoplectic condition, there is nothing to be
done in the way of medication, which can afford the slight-
est prospect of relief. It is true, a patient thus situated may
recover if his attack is not of the severest kind, but it is not

108

DISEASES OF THE BRAIN.

through any medicines we give him. Correct views relative
to this point are far from being prevalent, and can only be
established by regard being paid to the morbid anatomy and
pathology of the subject.

A clot in the brain is, to all intents and purposes, a for-
eign body, and both it and the walls of the cavity must un-
dergo certain fixed and definite changes. In order that these
changes may go on with the utmost possible regularity and
certainty, all the powers of the system are requisite. The
processes are not morbid ; on the contrary, they are in the
highest degree conservative. To take blood from a body
which is striving by all its agencies to repair an injury, is to
deprive it of a portion of its strength without in the slight-
est degree accelerating the actions at the seat of the lesion.
As Trousseau ' remarks, no physician ever thinks of bleed-
ing for an extravasation of blood under the skin, for he
knows how perfectly absurd such a practice would be ; and
yet, except as regards location, there is no difference between
it and the cerebral clot. A prize-fighter, for instance, re-
ceives a blow in the face which ruptures a blood-vessel and
gives him a " black eye." He has an extravasation of blood
into the cellular tissue. What would be thought of the phy-
sician who would recommend bloodletting from the arm
with a view of causing the absorption of the clot? The
prize-fighter has found out by experience that he can open
the skin with a knife and let the blood out. The practice
is excellent, and would be admirable for the brain also, were
this organ of no more vital importance than the skin of the
face. I have never bled a patient for cerebral haemorrhage
since 184:9, and I am very sure that I have had no reason to
regret the abandonment of the practice.

It is a common practice for purgatives to be given, and
even so conservative a practitioner as Dr. J. Hughlings Jack-
son ' puts " two drops of croton oil on the tongue," why, he

* Lectures on Clinical Medicine, Bazire's Translation, Part I., p. 10.
2 Reynolds's System of Medicine, vol. ii., Article Apoplexy and Cerebral
Haemorrhage, p. 541.

CEREBRAL HEMORRHAGE.

109

does not state, and certainly the practice is in direct antag-
onism not only with his assertion that " the chief thing is to
keep the patient quiet," but with the general tenor of his
theory of treatment. I have seen great annoyance and an
aggravation of the symptoms from the indiscriminate ad-
ministration of croton oil. It is only, in my opinion, admis-
sible when there is obstinate constipation, and when after
three or four days the bowels have not been moved.

And then as regards iodide of potassium. There seems
to be an idea prevalent that this substance exerts a powerful
influence in causing the more rapid absorption of the ex-
travasated blood, and hence it is frequently administered in
large and frequently-repeated doses. I have often seen pa-
tients, at as early a period as possible, while still in a state
of profound coma, dosed with the iodide of potassium to the
extent of five grains every hour, with the object of causing
the immediate absorption of the extravasated blood. That
such a result is impossible no one acquainted with the mor-
bid anatomy and the pathology of the subject will deny.

In fact, there is nothing to be done beyond keeping the
patient perfectly quiet, with the head well elevated, and in
a room, when possible, with a temperature of about 60° and
thoroughly ventilated. Indications should be met as they
arise. The bowels, if not moved naturally every day, may
be emptied by an enema of warm water ; the urine, if not
passed by the patient, should be drawn off with the cathe-
ter ; the strength, if feeble, as indicated by the pulse, should
be kept up by the cautious use of stimulants ; and, if the
patient is restless and does not sleep well, some one of the
bromides should be administered.

The food should be of the most nutritious character, so
as to be small in quantity, and should be taken frequently,
day and night. Beef-tea, or the extract of beef, made ac-
cording to Liebig's formula, supplies every indication.

If symptoms of inflammation make their appearance,
cold applications may be made to the scalp, or a blister

110

DISEASES OF THE BRAIN.

maj be applied to tlie nape of the neck. Blisters or mus-
tard plasters to the wrists or ankles are absurd.

Nothing should be done for the relief of the paralysis
till all signs of irritation of the brain have disappeared, and
the patient begins to feel the restraint of confinement, and
to make efforts to move his paralyzed limbs. These evi-
dences of improvement generally begin soon after the eighth
day. In about two weeks, therefore, it will be proper, in
the majority of cases, to take active measures to restore the
power of motion, and to prevent those contractions which
tend to make a restoration much more difficult. The agents
to be employed are passive motion, strychnia, phosphorus,
and electricity. The first is accomplished by flexing and ex-
tending the joints of the affected limbs, by friction, and by
kneading the muscles with the fingers. These movements
should be performed every day for five or ten minutes at a
time. The patient should likewise be encouraged to move
the limbs by his own volition as often as possible short of
causing fatigue. Strychnia should be given in doses of the
one-twenty-fourth of a grain three times a day, or, prefer-
ably, by subcutaneous injection, in somewhat smaller doses,
once a day. In old cases of hemiplegia, the effects of strych-
nia thus administered are often well marked, and are exhib-
ited when administration by the stomach has failed to pro-
duce a beneficial result. This is seen in the following brief
abstract of thirteen cases which will serve as types of nu-
merous others which have occurred in my private practice.

Case I. — H. A., aged fifty ; male ; right hemiplegia.
Came under treatment January, 1865 ; strychnia ineffectual
by the stomach; thirteen injections, of from one-thirty-
second to one-twenty-fourth grain ; much improved.

Case II. — J. S. ; forty-two ; male ; left hemiplegia. Feb-
ruary, 1865 ; thirteen injections ; much improved.

Case III. — S. T. ; sixty ; female ; right hemiplegia. Feb-
ruary, 1865 ; strychnia ineffectual by the stomach ; nine
injections ; much improved,

CEREBRAL HEMORRHAGE.

Ill

Case IY. — I. S. ; sixty ; female ; riglit liemiplegia. April,
1865 ; five injections ; much improved.

Case V. — ^M. T. ; fifty-two ; male ; riglit hemiplegia.
April, 1865 ; strychnia inefiectual by the stomach ; eleven
injections; cured.

Case YI. — O. S. ; sixty-three ; female ; left hemiplegia.
April 30, 1865; secondary contractions; twenty-two injec-
tions ; no improvement.

Case YII. — B. R. ; forty-seven ; male ; left hemiplegia.
June 11, 1865 ; strychnia ineffectual by the stomach ; seven
injections ; much improved.

Case YIII. — R. F. ; fifty ; male ; left hemiplegia. June,
17, 1865 ; strychnia ineffectual by the stomach ; eight in-
jections ; cured.

Case IX. — T. TV. ; forty-eight ; male ; left hemiplegia.
September 5, 1865 ; eight injections ; much improved.

Case X. — T. S. ; forty-nine ; male ; left hemiplegia.
September 7, 1865 ; secondary contractions ; five injections ;
no improvement.

Case XI. — J. J. ; fifty-seven ; male ; left hemiplegia.
September 11, 1865 ; secondary contractions ; no improve-
ment.

Case XII. — J. W. ; fifty-two ; male ; right hemiplegia,
affecting arm only, at the time treatment was begun, Sep-
tember 27, 1865 ; strychnia ineffectual internally ; six injec-
tions; cured.

Case XIII. — W. M. ; forty-five ; male ; left hemiplegia.
October 19, 1865 ; strychnia ineffectual internally ; seven
injections; cured.

Case XIY. — S. M. ; forty-one ; male ; right hemiplegia.
June 17, 1867 ; arm alone affected ; strychnia ineffectual
by the stomach ; twenty injections ; cured.

Case XY. — M. C. ; forty-four ; male ; right hemiplegia,
affecting tongue and face only. July 1, 1867 ; ten injec-
tions ; so much improved as to be able to talk with fiuency.

Case XYI. — C. C. ; fifty ; male ; right hemiplegia. May

112

DISEASES OF THE BRAIN.

4, 1869; stiyclinia ineffectual by the stomacli; thirty-five
injections ; much improved.

Dr. Charles Hunter ' has called attention to the advan-
tages to be derived from the hypodermic use of strychnia in
hemiplegia ; and my late clinical assistant, Dr. R. A. Yance,'
has adduced several cases to the same effect. Instances in
support of the views above set forth occur daily in my pri-
vate practice, and at the New York State Hospital for Dis-
eases of the ISTervous System. I have every reason, there-
fore, to be convinced of the good results to be derived from
the practice.

Phosphorus administered in the form of phosphide of
zinc, separately or in combination with the extract of nux-
vomica, according to the formula given on page 58, is also
a useful remedy.

But no agent is so valuable in hemiplegia as electricity,
and amendment almost invariably follows its use, even in
old cases, in which there are tonic contractions. If the case
is seen soon after the seizure, the induced current will gen-
erally be sufficient to produce contractions of the paralyzed
muscles. The poles, terminated by wet sponges, should be
applied to the skin covering the muscles, or in some cases to
the nerves. The current should be strong enough to cause
slight pain, or, if sensibility is lessened, to produce contrac-
tion. In old cases attended with atrophy of the muscles,
and diminished or abolished electro-contractility, the pri-
mary current may be necessary. It should be applied in such
a manner as to be interrupted, for contractions are only caused
when the circuit is closed and opened. As the muscles im-
prove in size and irritability, the induced current should be
used. Care should be taken not to fatigue the patient, or
to cause excessive pain by employing a current of too great
intensity.

1 British and Foreign Medico-Chirurgical Review, April, 1868.
« Journal of Psychological Medicine, April, 1870. The first thirteen
cases cited in this work were published in Dr. Vance's paper.

CEREBRAL HEMORRHAGE.

113

As regards the restoration of sensibility, it will gener-
ally be found to be less difficult than the removal of the
motor paralysis. The anaesthesia very often disappears or
becomes much less spontaneously, and it does so from the cen-
tre to the periphery ; that is, if there be ansesthesia of the
leg, the sensibility returns in the upper part first, and subse-
quently in the lower part. The treatment consists mainly
in the use of the electric wire-brush, which should be passed
gently over the skin previously made dry. The otlier pole
consists of a wet sponge. Either the induced or primary
current may be used. If the latter, however, be employed,
the wire-brush should constitute the positive pole.

I have frequently succeeded in curing almost complete
ansesthesia from cerebral haemorrhage by this treatment
alone. In recent cases it will almost invariably prove effec-
tual. Hyperaesthesia, if present, may be similarly managed.*

' The subject of the employment of electricity in medicine is too extensive
to receive more than slight notice in a work hke the present. For full details
in regard to it, the reader is referred to the author's translation of Meyer's
" Electricity in its Relations to Practical Medicine." New York : D. Appleton
& Co., 1870.

CHAPTER lY.

MENINGEAL H^MORREAaE.

By the term meningeal lisemorrliage is meant an extrava-
sation of blood into the subarachnoid space, or between the
dura mater and arachnoid.

S3nnptoms. — The most prominent symptom of meningeal
haemorrhage is coma, which may appear suddenly, or be pre-
ceded by premonitory symptoms, such as headache, vertigo,
and general convulsions. The stupor is usually profound,
and does not differ from that observed in the severe forms
of cerebral haemorrhage. The power of motion is generally
lost throughout the body, and consequently there is no
hemiplegia. The reason for this is, that the haemorrhage is
so extensive as to press upon both hemispheres. Reflex and
automatic movements remain, except when the medulla ob-
longata is involved, when some of them are abolished. In
this latter situation death soon takes place from cessation of
respiratory actions.

In ordinary cases the patient may pass out of the coma-
tose condition from the fact of the brain becoming accus-
tomed to the pressure, and he then may be able to speak,
and to move his limbs, but his mental and physical faculties
are greatly enfeebled, and a renewal of the haemorrhage
again plunges him into a state of coma, from which he may
again emerge. This sequence may be repeated several times,
until death at last takes place. Before this termination
there are vomiting, incontinence of urine and faeces, insen-
sibility, and occasionally general convulsions.

MENINGEAL HEMORRHAGE.

115

It has sometimes happened that meningeal hjBmor-
rhage, resulting from an injury of the cranium, has not
caused any very prominent symptoms for a considerable
period afterward. A teamster was struck on the head by a
club in the hands of another man, was stunned for a few
minutes, then recovered, and went about his business with-
out complaining of his head. In about twelve hours after-
ward coma supervened, and he died without being aroused.
A case is reported by Dr. Gibson,^ in which a still longer
period intervened. A man, of about sixty years of age, was
found one morning, about eight o'clock, seated as if asleep
at a desk, his arms crossed before him and his head resting
on them. It was discovered that he was profoundly insen-
sible. He was sent to the hospital, where he lay comatose,
breathing stertorously, and paralyzed on the whole of one
side. At the end of two days he died. On post-mortem
examination there was found fracture of the left side of the
cranium, with rupture of the dura mater and middle menin-
geal artery, from which latter, extensive haemorrhage had
taken place. It was ascertained that, five days before, he had
fallen down a stone staircase, was stunned for a few minutes,
but had soon recovered his senses. Doubtless during the
whole of the intervening period the bleeding from the rup-
tured vessel had been going on.

Causes. — Meningeal hemorrhage is often produced by in-
juries of the skull, and results from sudden rupture of a
healthy artery or vein. It may follow blows on the head,
falls, or injuries with instruments which perforate the crani-
um, and may or may not be associated with fractures of the
bones.

The larger vessels, or the capillaries, may give way from
being diseased, and consequently unable to resist the ten-
sion of the blood. Such a condition may be the result of
the long-continued excessive use of alcoholic liquors, or may
be due to hepatic disease.

> Edinburgh Medical Journal, September, 1870, p. 199.

116

DISEASES OF THE BRAIN.

In new-born children, tliere is sometimes meningeal lisem-
orrhage from the pressure made by the instruments used to
effect delivery.

The Prognosis in meningeal haemorrhage is always un-
favorable, death occurring either during the state of coma
which first appears, or in some one of the subsequent acces-
sions.

Diagnosis. — Meningeal haemorrhage is readily distinguish-
able from cerebral haemorrhage by the facts that the stupor
comes on gradually, that there is no hemiplegia, and by the
remissions which take place when the patient does not die
at first.

The Morbid Anatomy and the Pathology call for no ad-
ditional remarks beyond those already made ; and the Treat-
ment does not differ from that proper in cerebral haemor-
rhage.

HjEmatoma or the dtjea matee.

A peculiar form of meningeal haemorrhage, called haema-
toma, is met with under the dura mater. The blood is not
diffused, but is collected in sacs which are formed of false
membranes, the result of chronic inflammation. These cap-
sules are flattened ovals in shape, are three or four inches
in diameter, and half an inch thick. They are usually situ-
ated at the vertex, and involve both hemispheres. "When
this is the case, the paralysis which results is bilateral.

Symptoms. — The initial symptoms of haematoma of the
dura mater are the results of chronic inflammation, and are
slow in their progress. In many respects they resemble
those indicative of softening, and consist of weakness of in-
tellect, vertigo, a dull, circumscribed, persistent pain, and
more or less tendency to stupor. The power of motion is
generally diminished on both sides of the body, though oc-
casionally there is hemiparesis. Paralysis is scarcely ever
complete. Gradually, through a period extending over sev-
eral months, the stupor increases, and finally the patient

MENINGEAL HAEMORRHAGE.

117

becomes apoplectic. During the whole course of the dis-
ease the pupils are strongly contracted. The patient dies
comatose and frequently convulsed.

Causes. — ^Early and old age are both predisposing causes,
the disease being met with mainly in children and very old
persons. It is frequently seen in the insane, and may prob-
ably result from rheumatism, the excessive use of alcoholic
liquors, and fevers. The cause is sometimes to be found in
wounds or injuries of the skull.

Diagnosis. — It is doubtful if hsematoma of the dura mater
can be definitely recognized either in the stage of inflamma-
tion or that of haemorrhage. Legendre * states that, in chil-
dren, the most important diagnostic mark is the permanent
contraction of the hands and feet, which is so generally pres-
ent ; but this symptom is certainly met with in other
cerebral disorders, and may even result from reflex irri-
tations. The diagnosis is rendered still more difficult by the
fact that the disease under consideration is often associated
with other cerebral disorders which mask or modify its symp-
toms. The absence of fever, the contraction of the pupils,
the slowness and irregularity of the pulse, the facts that
there are no vomitings and no general convulsions, that the
nerves distributed to the several parts of the face are not
paralyzed, that there are constant and very severe headache,
and a gradually increasing tendency to stupor, are, accord-
ing to Jaccoud," sufficient to indicate the presence of hsema-
toma of the dura mater. I am of the opinion that they only
enable us to give a guess which has some basis in proba-
bility, for I have several times witnessed exactly such a con-
dition as that described, and after death found other morbid
conditions than hsematoma.

The Prognosis is unfavorable, death resulting sooner or
later, according to the extent of the disease and the natural
powers of the patient.

* Recherches sur quelques Maladies de I'Enfance, Paris, 1846.

* Traite de Pathologic Interne, tome i., Paris, 1870.

118

DISEASES OF THE BRAIN.

Morbid Anatomy and Pathology. — The first stage of lisema-
toma of the dura mater is characterized by the formation of
the false membranes, to which allusion has already been
made. These membranes are found on the internal surface
of the dura mater, and are reticulated, presenting somewhat
the appearance of spiders' webs. They generally have their
seat near the sagittal suture, and extend to both hemispheres,
being only separated from them by the arachnoid and pia
mater. Yirchow, who has studied their formation with
greater care than any other observer, has found more than
twenty layers of them, one on top of the other, and traversed
by numerous blood-vessels.

Owing to this great vascularity, to the extreme tenuity
of the vessels, and to the absence of any perivascular sup-
port, haemorrhage is liable to occur, and the several lamellas
thus constitute a sac into which the blood may be poured.
This, pressing upon the cerebrum below, and constantly
being enlarged by subsequent haemorrhages, gives rise to the
symptoms observed during life. The vessels may be more
liable to rupture from the existence of atheromatous degen-
eration of their coats.

Treatment. — This requires no amplification at my hands,
as I do not believe in the efiicacy of any means in curing
the afiection. All that can be done is to palliate the more
violent symptoms, such as the headache and feebleness of
mind and body, by anodynes and stimulants, and of these,
morphia administered hypodermically, and alcohol in some
one or other of its numerous forms, are to be preferred.
Bloodletting and blistering are worse than useless.

CHAPTEE Y.

PARTIAL CEREBRAL ANEMIA FROM OBLITERATION OF CERE-
BRAL ARTERIES.

One or more arteries of the brain may be obliterated and
anaemia of those parts supplied by it produced through the
action either of thrombosis or embolism.

THROMBOSIS.

By thrombosis is understood a condition in which a blood-
vessel undergoes narrowing of its calibre by the deposition
of fibrine from the blood on its internal surface. The clot
thus formed is called a thrombus.

Symptoms. — The phenomena observed in consequence of
the formation of a thrombus in a cerebral artery are grad-
ual in their development, and are often interrupted by stages
of apparent improvement. Headache, as in so many other
affections of the brain, is a prominent symptom and is almost
constantly present. It is rarely diffused over the whole
head, but occupies a place having a close relation in situa-
tion with the seat of the disease. It is rarely of a very ag-
gravated character, and is remarkable rather for its persist-
ency than its severity. In several cases which have come
under my notice, the pupil of the eye of the affected side
was dilated from the first, and there were ptosis and strabis-
mus, showing that the third nerve was involved.

At a very early period in the progress of the disease it is
not uncommon to meet with marked difficulties in the fac-
ulty of speech, and these not only relate to the articulation,

120

DISEASES OF THE BRAIN.

but to the memory of words. As regards the first-mentioned
form, there may be restraint in the movements of the tongue,
the lips, or both, or there may be a loss of coordinating pow-
er in the muscles concerned in speech without any actual
paralysis. Special inconvenience is, therefore, experienced
when attempts are made to pronounce words in which the
labial and lingual letters are prominent. The gutturals in
such cases are enunciated without difficulty. In the other
form in which the memory of words is impaired, the patient
is constantly at a loss for language with which to express
his ideas ; and, though the proper words may be supplied to
him, he almost immediately forgets them again. The full
consideration of this interesting subject will be found under
the head of aphasia.

Yertigo, though generally present, is not usually severe,
at least in the early stages.

The incipient symptoms of paralysis soon make their ap-
pearance in the majority of cases, and, though there is a grad-
ual advance in the loss of power, there are periods of almost
entire remission. Thus the leg, or the arm, or the face, may
be the original seat of the paralysis, and eventually the
whole of one side be involved. In a case of thrombosis in a
gentleman now under my charge, the paralysis was at first
limited to the muscles supplied by the ulnar nerve and those
concerned in deglutition. For one period of five days after
I first saw him, there was an entire remission of his symp-
toms, and he could move his hand and swallow as well as
ever, but gradually the power was again lost, and other mus-
cles became involved. At the present time (December 1,
18T0), he is almost entirely hemiplegic.

Sensibility is also generally abolished or impaired on the
paralyzed side, and thus the various forms of numbness,
such as tingling, formication, etc., are present.

The mental symptoms are usually apparent from the first,
but may be altogether absent or else so slightly shown as not
to attract attention. The memory is impaired, not only as

PARTIAL CEREBRAL ANEMIA, ETC.

121

regards words to which reference has already been made,
but also events and circumstances, especially those of recent
date. The names of persons and things are likewise readily
forgotten. In the case of a gentleman whom I saw in con-
sultation, and in whom I diagnosticated thrombosis, there
was left hemiplegia involving both arm and leg, but not the
foot, which had begun in the fingers and gradually extended.
There was no special difficulty of speech except as regarded
the recollection of words, but the memory was wonderfully
impaired in every other respect. I entered his room upon
one occasion just as the servant was carrying out a tray with
the remains of his breakfast. Not three minutes had elapsed
since he had eaten, and yet he assured me he had tasted
nothing since the day before. The loss of memory was the
first symptom observed in this case. Soon afterward he be-
gan to improve, and he is now, after fifteen months, free
from paralysis, and with his memory almost as good as ever.
The loss of memory'in such cases seems to be due in the
main to the fact that the power of concentrating the atten-
tion upon any subject is very much diminished. There is
likewise an indisposition to exert the powers of the mind or
body, and thus the patient tends to pass into a condition of
apathy. Somnolence is a frequent symptom.

During the first stage of thrombosis, before the artery is
entirely closed, amendment, and even complete recovery,
may take place. The remissions in the symptoms already
referred to are due to the establishment of the collateral
circulation, and this may become so complete as to eventu-
ate in cure. It must be confessed, however, that the condi-
tion of anaemia to which the foregoing symptoms are due,
in the great majority of cases ends in softening — a sub-
ject which will presently be considered as one of the conse-
quences of thrombosis and other morbid states.

Causes. — Thrombosis may result from atheroma of the
artery, by reason of which its elasticity is diminished and
the smoothness of its lining membrane destroved. Both

122

DISEASES OF THE BRAIN,

these conditions retard the course of the blood, and favor
the deposition of fibrine on the internal periphery. The
walls of the vessels may be healthy, and a thrombus may
then be formed through a weak action of the heart — the
result of fatty degeneration or other cause impairing its
strength.

The predisposing causes are, age — the disease being rare
in persons under fifty years — the excessive use of alcoholic
liquors or of fatty or starchy articles of food, with insuffi-
cient exercise, and perhaps inordinate mental exertion,
which, by impairing the tone of the arteries, in consequence
of their constant overdistention, diminishes their elasticity,
and may consequently lead to the formation of thrombi.

Diagnosis. — Thrombosis is distinguished from cerebral
congestion by the facts that the mental and other symptoms
are more profound in character, and that the patient has
generally passed the prime of life. The existence of paraly-
sis among the early symptoms will likewise tend to the
formation of a correct opinion. From cerebral heeraorrhage
it is diagnosticated by the circumstance of its gradual devel-
opment ; from encephalitis by the absence of fever and the
• more chronic nature of the disease ; and from embolism by
its slow progress and the impossibility of defining the exact
period of its beginning.

Prognosis. — The prognosis in cerebral thrombosis is unfa-
vorable, for the reason that, although the morbid process
may advance slowly, and may even be spontaneously arrest-
ed in its course before the artery is closed, the tendency to
complete obliteration is always great, and the chance of suffi-
cient circulation being carried on by the collateral vessels is
very remote. The disposition to softening, therefore, always
exists, and generally cannot be overcome. The inadequacy
of any medical treatment to control the action going on
within the artery, or to aid to any great extent in the devel-
opment of the collateral circulation, is also an element in
forming an opinion as to the ultimate result.

PARTIAL CEREBRAL A>^^MIA, ETC.

123

Morbid Anatomy and Pathology. — Although Virchow ' was
the first to write distinctly in regard to the nature of throm-
bosis, the condition was recognized long before his researches
were made, and cases of clots plugging up the vessels are to
be found detailed by many of the older medical authors,
among whom Abercrombie, Carswell, and Cruveilhier, may
be mentioned. Since Yirchow began his observations in this
direction, many instances have been recorded and a large
number of memoirs have been issued upon the subject. An
interesting case was related by Dr. Packard,' of Philadelphia,
at a meeting of the Pathological Society of that city held in
December, 1859. The patient, who had been under the care
of Dr. Heller, was a bachelor, fifty-one years of age. At six
o'clock in the morning, at the beginning of February, lie was
seized with paralysis of the left arm and leg. He was a man
of very regular habits, and of fanatical love for every thing
instructive, and an accomplished scholar in botany, geogra-
phy, and languages. The paralysis was soon relieved, and he
was able, four weeks afterward, to go out again and to use
his arm tolerably well. About the middle of March, in con-
sequence of a fatiguing walk the previous evening, and an
attack of diarrhoea during the night, complete paralysis re-
turned. From this he never recovered, but yet did not die
till the December following. Previous to this termination
he had confusion of ideas and delirium. Upon post-mor-
tem examination, among other morbid changes, a cavity in
the right corpus striatum was found, and this was surround-
ed by a spot of softening of the cerebral substance as large
as an egg. The basilar artery was completely blocked up
with clots, as was also the riglit carotid. These vessels
were atheromatous, and the basilar artery was aneurismally
dilated. The clots had all the appearance of being old.

Dr. Dickinson ' has brought forward five cases of occlu-

' Froriep's Neue Notizen, 1846. Heft xxxvii.

^ North American Medico-Chirurgical Review, vol. iv., 1860, p. 306.
' On the Formation of Coagulse in the Cerebral Arteries. St. George's
Hospital Reports, vol. i., 1866, p. 257.

124

DISEASES OF THE BRAIN.

sion of arteries, several of which I am disposed to think
were of embolism, instead of thrombosis, as he considers
them to be. Dr. Dickinson nowhere alhides to Virchow's
investigations, but gives the whole credit of the discovery
of the relation between emboli and the formation of con-
cretions in the heart to Dr. Kirkes. The conclusions which
he draws from his cases are by no means original, although
he evidently so regards them.

The questions to be considered in connection with the
morbid anatomy of thrombosis relate to the condition of the
artery, the nature of the clot, and the changes which take
place in those parts of the brain which are deprived of their
due supply of blood.

The affections of the artery, being similar to those which
render it liable to rupture, need not be dwelt upon at any
length here, as they have already been noticed under the
head of the morbid anatomy of cerebral haemorrhage. Suf-
fice it, therefore, to say that endarteritis and atheromatous
degeneration are the diseased states generally met with.

The clot which closes the vessel is, in the beginning,
coagulated blood, and hence consists of fibrine and white and
red blood-corpuscles. The elements, with the exception of
the fibrine, are gradually disintegrated and washed away by
the current of blood which continues to flow through the
vessel before it is entirely closed, and therefore the layers
nearest the arterial wall consist almost entirely of fibrine
and the one nearest the centre of the vessel, which is the
latest formed, of fibrine and corpuscles. An examination of
such a clot with the microscope shows that the above-men-
tioned morphological elements are found in its centre, more
or less changed, however, according to the age of the forma-
tion. A thrombus may undergo purulent softening and dis-
integration to such an extent as to result in its breaking up
into fragments, which may lodge in the vessel or its branches
farther on, and thus constitute emboli.

The region of the brain to which the artery undergoing

PARTIAL CEREBRAL ANEMIA, ETC.

125

occlusion is distributed is, of course, deprived to some extent
of its blood, and hence presents at first an appearance of
anaemia. And this is not prevented by the increase of the
collateral circulation, which is never sufficiently vigorous to
compensate entirely for the loss by the primary vessel.

Microscopic examination shows the capillaries to be
smaller and less numerous than in the normal condition,
though there is not any palpable softeniug.

But after the artery is entirely closed a change ensues.
The anaemic portion of the brain becomes red or pink, and
this color is deepest on the borders, owing to the collateral
circulation which is now fully established. This stage has
been called red softening, but I am disposed to think the
designation erroneous, and that it is liable to convey false
ideas of the pathology. For it is perfectly possible at this
time for the anaemic portion of the brain to be restored
through the activity of the collateral circulation, with the
effect of causing a cessation of the symptoms. If, however,
this should be insufficient to provide for the due nutrition
of the affected region, softening takes place, and a cure be-
comes almost impossible.

Obliteration of a cerebral artery does not always produce
notable symptoms. For these to follow, the morbid process
must be set up in a vessel with but few and small collateral
branches. Thus, if the internal carotid be obstructed, the
circulation is carried on through the circle of Willis by the
supply of blood derived from the vertebrals. The basilar
artery might also be occluded at any limited region between
a pair of transverse arteries, and the circulation still kept up
by the carotids on the one side, and the vertebrals on the
other. But any closure so as to involve one or more of the
transverse arteries must lead to anaemia, and subsequent soft-
ening of the pons Varolii. Thus, in a case reported by Ben-
nett,* in which there had been vertigo and other head-symp-

* Clinical Lectures on the Principles and Practice of Medicine, third edition,
Edmburgh, 1850, p. 370

126

DISEASES OF THE BRAIN.

toius for several years, and in whicli paralysis of the left
arm, without loss of consciousness, had suddenly supervened,
the basilar artery was found entirely obliterated throughout
its entire extent, all the transverse arteries were of course
closed, and the supply of blood to the pons cut off on both
sides of the mesial line.

A very interesting memoir by Hayem ^ alleges occlusion
of the basilar artery by thrombus to be a cause of sudden
death. In all of his cases, four in number, the artery was
closed throughout a great part of its extent, as the result of
extensive arteritis and the formation of dense clots. In the
fourth case there was also thrombosis of the left middle
cerebral artery, with difficulty of speech.

The vessels the closure of which produces the greatest
disturbance of function are the anterior, middle, and poste-
rior cerebral which supply the hemispheres, the corpus stria-
tum, optic thalamus, and other important ganglia. Be-
sides the effect due directly to the anaemia, more or less dis-
turbance results from the congestion posterior to the clot,
and the consequent effusion of serum.

Treatment. — A knowledge of the morbid anatomy and
pathology of cerebral thrombosis must satisfy us of the in-
sufficiency of any medical treatment to cause the absorption
of the clot obliterating the channel of the artery. Yet I
have several times heard it gravely proposed to administer
the iodide of potassium, with the view of accomplishing this
object. As regards facilitating the establishment of the col-
lateral circulation, nature will generally take care of this,
and may even so far overdo it as to cause haemorrhage from
the rupture of vessels not accustomed to the increased tension
of the blood. It may therefore be necessary, in this latter
condition of excessive action, to give the bromide of potas-
sium in large doses. Should the circulation be feeble, the
skin cold, and the patient disposed to somnolence, we

1 Sur la Thrombose par Arterite du Tronc Basilaire, comme cause du mort
rapide, Archives de Physiologic Normale et Pathologique, 1868, p. 270.

PARTIAL CEREBRAL ANEMIA, ETC.

127

have reason to suppose that the collateral circulation is not
being formed with sufficient rapidity, and therefore the pa-
tient should be kept with the head low, brandy or other
spirituous liquors administered, and the body wrapped up
in warm blankets.

For some time after the successful establishment of the
collateral circulation there is more or less feebleness of mind
and body. For this condition strychnia and phosphorus are
especially applicable, and may be administered according to
the formulas recommended under the heads of cerebral con-
gestion and cerebral haemorrhage. Electricity is almost
always useful.

EMBOLISM.

Embolism is the term applied by Yirchow to the closure
of an artery by an embolus, which is a clot formed in some
other part of the body and transported by the current of the
blood to the vessel which it occludes. It therefore differs
from thrombosis in the facts that it is not associated with
previous disease of the artery, and that the closure of the
vessel is sudden.

Symptoms. — There are no premonitory symptoms. As in
cerebral haemorrhage, the patient may be sitting perfectly
quiet when he suddenly loses consciousness and falls to the
ground, comatose. As the stupor passes off, he finds that he
is paralyzed upon the side of the body opposite to the seat
of the lesion.

Or there may be no coma, but merely slight confusion
of ideas for a moment or two with sudden accession of paral-
ysis on a limited portion of one side, involving only the arm
or leg. Or, again, the face or the tongue may be the only
parts paralyzed. Or there may be no paralysis anywhere,
and no mental symptoms except as regards the faculty of
language, which is entirely or partially lost.

Sometimes there are ocular troubles, such as ptosis, stra-
bismus, or blindness.

128

DISEASES OF THE BRAIN.

Experience sliows that the embolus, for reasons which
will be given hereafter, generally lodges in the left middle
cerebral artery, and that with the right hemiplegia — if there
is paralysis at all — there is often aberration of the facidty
of speech.

The symptoms of mental derangement, with the excep-
tion of the coma of severe attacks, are not ordinarily promi-
nent. I have, however, witnessed several cases in which
they formed a very striking feature of the case. In one of
these, in which the clinical history of the patient disclosed
the preexistence of several attacks of acute articular rheu-
matism, with subsequent endocarditis and mitral and aortic
valvular lesions, there were hallucinations and delusions in
addition to the complete paralysis of the left side. All these
phenomena entirely disappeared within thirty-six hours.
This case is one of the few in my experience in which the
embolus had occluded an artery on the right side of the
brain.

In another, likewise with valvular disease of the left
side of the heart, there was delirium from the first, and this
disappeared as the collateral circulation was established.

Erlenmeyer has written very excellently of cerebral em-
bolism, but is, I think, incorrect in some points of his symp-
tomatology. He states the ordinary phenomena of an at-
tack to be as follows :

There are no prodromata ; sudden loss of consciousness,
with paralysis of several parts of the body. The facial, the
hypoglossal, and the nerves of the extremities, are always
more or less afi'ected. Sensibility is abolished in the con-
junctiva, but is retained in the cornea. The pupils remain
sensitive, and are neither contracted nor dilated, neither are
there symptoms of concussion or compression. There are no
vomitings and no contractions. The pulse is weak and
small, and the temperature rather below the normal stand-
ard. Occasionally there are epileptiform convulsions. Psy-
chical troubles do not ordinarily appear till the collateral

PARTIAL CEREBRAL ANEMIA, ETC.

129

circulation becomes active, and local liyperaemia is thus in-
duced.

The principal exception I have to make to the foregoing
sequence of symptoms is the too absolute assertion of the
paralysis of the facial, hypoglossal, and other nerves. I
have seen several cases in which there was no paralysis to
be detected in any part of the body by the most careful ex-
amination, and several others are on record. In one very
interesting instance, occurring in a lady who had had re-
peated attacks of acute rheumatism, and who had at the
time marked aortic insufficiency, headache and vertigo sud-
denly occurred while she was conversing with a friend, and
her speech was cut short with as much suddenness as though
she had been shot. There was no paralysis of the tongue,
but all idea of language was abolished. Within forty-eight
hours she recovered entirely the faculty of speech. In an-
other, that of a gentleman with a similar clinical history,
headache, vertigo, confusion of ideas, and amnesic aphasia,
suddenly supervened. That both these were cases of embo-
lism can scarcely, I think, be doubted.

And then, as regards the state of the pupils, my experi-
ence does not coincide with that of Erlenmeyer, for I have
frequently found either dilatation or contraction of both
pupils, or dilatation of one and contraction of the other.

In examining a case of recent embolism, the ophthalmo-
scope should always be used to view the fundus of the eye,
and even in old cases valuable signs will often be obtained.
The middle cerebral artery, the ordinary seat of embolus,
arises from the internal carotid after the anterior cerebral
and oplithalmic have been given off. Occlusion of its chan-
nel must, of course, throw an increased amount of blood into
these last-named arteries, and, as the arteria centralis retinae
is derived from the ophthalmic, it and its branches become
enlarged. The ophthalmoscope will enable us to discover
the congestion thus produced, and will often be the means
of helping us to determine, in the absence of paralysis,
9

130 • DISEASES OF THE BRAIN.

which side of the brain is the seat of the lesion. In older
cases we will frequently find retinal congestion.

The following case I quote not only as being the first of
which I have any knowledge in which the ophthalmoscope
was used in a case of cerebral embolism, but as being inter-
esting from the fact that the embolus was on the right side.
It is reported as

Cerebral Emholism following Valvular Disease of the
Heart. — John TurnbuU, aged seventeen, was admitted into
the Hull General Infirmary, on April 25, 1 867. He was tall,
much wasted, and had a suffering expression, and converg-
ing strabismus of the left eye, the mouth being drawn very
slightly toward the left side. Pulse 70, very thrilling in
character, and a large coarse systolic murmur near the left
nipple. He was perfectly sensible, complained of severe
frontal headache, with confusion of vision, and stated that
he had been in much the same condition for seven weeks,
his illness beginning spontaneously with headache and vom-
iting, unaccompanied by loss of consciousness or convulsions.
He had had an attack of acute rheumatism in the previous
summer. He was ordered gr. iij of blue-pill and gr. ij of
extract of henbane in a pill, and a draught of acetate of am-
monia, three times a day, and spirit-lotion to the head.
" 1^0 marked alteration in his condition, except progressive
debility, took place till May 2d, when he complained of in-
creased headache and dimness of vision, and being unable
to expectorate, from excessive weakness, death from bron-
chial obstruction threatened. With the aid of some cham-
pagne, he rallied in about twenty-four hours, aiid at the end
of a week was nmch improved, having a clean tongue and
good appetite, but the headache, strabismus, and deviation
of the tongue to the left, remained. On May 16th it was
noticed that these symptoms had passed off, with the excep-
tion of the last mentioned. He was ordered a mineral-acid
mixture.

" A week later, as he still complained of some dimness

PARTIAL CEREBRAL ANEMIA, ETC.

131

of sight, he was examined with the ophthalmoscope. The
retinal vessels were found much enlarged, and the veins very
tortuous ; the optic nerve-entrance of an intense red color,
not being distinguishable from the surrounding parts except
by the entrance of the vessels, the redness being chiefly due
to a number of very fine vessels radiating from the centre.
There was no morbid effusion in any part. He could spell
easily from 'No. 15 of Jaeger's test-types (being unable to
read and write). He was again examined at the end of
another week, when the optic nerve-entrance was observed
to be paler in color, so that its circumference could be dis-
tinguished, but still much injected, and the vessels nearly as
large and tortuous as before ; sight was apparently perfect.
He was discharged convalescent.

" The peculiar form of paralysis in this case denoted
some morbid condition within the cranium, which appeared
to have its most easy and natural explanation in cerebral
embolism, an opinion further supported by the perfect re-
covery of the patient. The case received much additional
interest from the information afforded by the ophthalmo-
scope, for one may fairly believe that the intense congestion
of the retinae denoted a similar condition of the brain, per-
haps a state of reaction after the circulation had been re-
established through collateral channels."^

Causes. — The most common first step in the causation of
cerebral embolism is acute articular rheumatism, which, by
inducing acute endocarditis, leads to the formation of em-
boli on the valves of the heart and other parts of the en-
dangium. Aneurisms of the aorta or other large artery,
resulting in the coagulation of the blood in the aneurismal
sacs, may likewise induce it, by a portion of the clot being
washed off by the current. Esmarch" details a case in
which, while an examination was being made of an aneu-

' British Medical Journal, 1867, also Quarterly Journal of Psychologi-
cal Medicine, January, 1868, p. 118.

* Archiv fiir Pathol. Anatomie und Physiologic, B. xi.. Heft. 5, 185Y.

132

DISEASES OF THE BRAIN.

rism of the carotid, the patient suddenly fell back in an
apoplectic stupor. The whole right side was at once para-
lyzed, the facial muscles on the left were convulsed, and
four days afterward death ensued. Post-mortem examina-
tion showed that the left internal carotid, the middle cere-
bral, and the ophthalmic, were completely closed by coagula,
which were identical in structure and appearance with the
clot in the aneurismal sac.

Emboli may also originate in the lungs, and, entering
the left auricle through the pulmonary veins, finally lodge
in a cerebral artery.

Age appears to exercise no influence over the formation
of emboli, but men are much more commonly the subjects
than women, for the reason, undoubtedly, that they are
more liable to attacks of rheumatism.

Of thirty-seven cases under my care, either alone or in
consultation, in which I had reason to diagnosticate cerebral
embolism, there was organic disease of the heart in all but
one. Three of the cases were over sixty years of age ; four
between fifty and sixty ; seven between forty and fifty ;
thirteen between thirty and forty; and ten under thirty.
Twenty-five were males and twelve were females.

Diagnosis. — From cerebral hsemoiThage, embolism may
be distinguished by the following signs. It occurs without
relation to age, while haemorrhage is much more frequent
in persons over forty ; there are no prodromata : the result-
ant paralysis is generally on the right side, while in haemor-
rhage there is no such predisposition ; and it is in the great
majority of cases associated with organic disease of the left
side of the heart. Care, however, must be taken not to
overestimate the value of this diagnostic mark, valuable as
it is. In one case under my charge, in which the symptoms
pointed strongly to the existence of a cerebral embolus, and
in which, after death, the left middle cerebral artery was
found occluded, the heart was perfectly healthy ; and in one
other, in which cerebral embolus was diagnosticated, and in

PARTIAL CEREBRAL ANEMIA, ETC. I33

which there was mitral regurgitation, extravasation into the
corpus striatum was discovered to be the cause of death. A
case has recently been reported by Dr. J. Hughlings Jack-
son/ in which there was cerebral hsemorrhage with hemi-
plegia, together with extensive valvular disease of the heart.

A patient now in the New York State Hospital for Dis-
eases of the Nervous System has left hemiplegia, involving
face, arm, and leg. It has already lasted seven months, al-
though greatly improved. The hand and arm are much
contracted. The attack was apparently induced by strong
muscular exertion being made while in a stooping and con-
strained position. Most physicians would be disposed to
agree with my diagnosis, that the case is one of cerebral
haemorrhage, for the obvious cause of the paroxysm, the
lesion being on the right side of the brain, the steady im-
provement and the muscular contractions, all point to ex-
trasavation of blood instead of embolus. Yet he is under
twenty years of age, and, before the seizure, had an attack of
acute rheumatism, with heart-difficulty. He now has aortic
and mitral regurgitation. Such cases as the above are very
instructive, and they show us how necessary it is to weigh
all the facts, and how great is the possibility of making a
mistake after all. For, although I am inclined to the view
of haemorrhage, no definite opinion can be given without a
post-mortem examination.

Still in a case of partial or complete hemiplegia, with or
without apoplexy, in which the patient was below the age
of forty, with the hemiplegia involving the right side, no
muscular contractions and organic disease of the left side of
the heart, with or without previous attacks of acute articu-
lar rheumatism, cerebral embolus may safely be said to
be the cause of the symptoms. Moreover, the paralysis
from embolism, if it does not disappear within seventy-
two hours after the seizure, does not gradually fade away as
it so frequently does to a great extent in haemorrhage.

' British Medical Journal, October 29, 18Y0, p. 459,

134

DISEASES OF THE BRAIN.

The suddenness with which embolism takes place, to
say nothing of the other points in the clinical history, will
suffice for the discrimination from thrombosis.

Prognosis. — The prognosis in cerebral embolism is grave,
for the reason that the tendency to softening of the anaemic
cerebral tissue always exists. But, if the patient passes over
the first four or five days without any aggravation of his
symptoms, and especially if they be mitigated in violence,
there is considerable hope of a favorable result. Still, a
guarded opinion should always be given till all head-symp-
toms have disappeared.

Morbid Anatomy and Pathology. — The first rational expla-
nation of embolism was made by Yirchow,' in 1847, who,
in his paper on acute inflammation of the arteries, distinctly
explained the manner in which the vessels were occluded by
clots transported in the blood from distant parts of the body,
and who associated these coagula with valvular disease of the
heart. In two of the cases cited by him in which arteries
were found closed by such clots, the valves of the heart were
discovered to have others still attached to them, and exhib-
ited traces of the separation of those which were found in
the vessels.

Subsequently (in 1852), Dr. Senhouse Kirkes " called spe-
cial attention to the plugging up of the middle cerebral
artery as a cause of softening of the brain. Three cases, in
which death followed, are adduced, in each of which the
condition of non-inflammatory softening was found to exist
in the brain. Dr. Kirkes's observations appear to have been
made without any knowledge of Yirchow's prior researches.
He states that the paralysis met with in young persons may

1 Ueber die akute Entzundung der Arterien. Archiv fiir Pathol. Anato-
mic, B. i., 1847, p. 2*72. In a paper on Occlusion of the Pulmonary Artery, pub-
lished in Froriep's Neue Notizen in 1846, he enunciated a similar theory.
• * On some of the Principal Effects resulting from the Detachment of Fi-
brinous Deposits from the Interior of the Heart, and their Mixture with the
Circulating Fluid. Medico-Chirurgical Transactions, vol xxxv., 1852.

PARTIAL CEREBRAL ANEMIA, ETO.

135

be due to the interruption of a due supply of nutriment to
the brain by the occlusion of an artery by a plug derived
from the left side of the heart.

Schutzenberger/ among others, has written with great ful-
ness on this subject. Among other conclusions not specially
applicable to the particular point now under consideration,
he states that fibrinous concretions may form in the heart,
or large vessels may subsequently be detached and carried
by the blood to the cerebral arteries, where they produce
symptoms not essentially different from those noticed in
cerebral haemorrhage or acute softening.

The only essential points of difference under this head
between thrombosis and embolism, are the suddenness of the
attack, the part of the brain most liable to be affected, the
origin of the clot, and the state of the blood-vessel which is
obliterated.

Relative to the first, the abrupt closure of a vessel as in
embolism will, of course, produce more violent symptoms
than if the occlusion has taken place gradually, and thus
time have been afforded for the establishment of the collat-
eral circulation. In the first case, not only is the blood at
once shut off from a portion of the brain, but the vessels be-
hind the clot receive a greater quantity than they normally
do, and hence the regions they supply are immediately con-
gested. In examination of the brain of a person who has
died during the first stage of cerebral embolism, we find
those parts of the brain ordinarily supplied by the obliterated
vessel paler than natural, with a zone of congested tissue,
and perhaps numerous small extravasations of blood on the
periphery.

The place where emboli are most frequently found is, as
has already been stated, the left middle cerebral artery. The
left common carotid arises from the arch of the aorta in a
line almost exactly coinciding with the course of the blood-
current. It therefore happens that an embolus which has
' Gazette des HOpitaux, No. 80, ISS^.

136

DISEASES OF THE BRAIN.

formed on the lining membrane of the heart, and which has
passed into the aorta after having been detached, enters this
vessel instead of the innominata. From the common carotid
it passes into the internal carotid and thence with the
stronger and more direct current into the middle cerebral
artery, which is lodged in the fissure of Sylvius. Of forty-
two cases of cerebral embolism collected by Meissner, in
thirty -four the left hemisphere was the seat. Of thirty-seven
cases occurring in my own practice, and to which reference
has been made, thirty-one were accompanied with right
hemiplegia, and were consequently on tlie left side of the
brain. Post-mortem examinations were made in seven of
these cases, and in all the embolus occupied the left middle
cerebral artery.

The pathology of the genesis of the clot has already been
sufiiciently dwelt upon in other connections, and the fact
that the artery in which it is found is not diseased has been
mentioned.

The further consequences of embolism belong to cerebral
softening and will be considered under that head.

Treatment. — It is not necessary to make any remarks on
this point in addition to those made in regard to the treat-
ment of thrombosis. There is very little to be done besides
meeting indications as they arise, and attempting to relieve
the paralysis and other vestigia, for which ends my views
have been sufficiently expressed in the preceding chapters.

CHAPTER Yi;

CEREBRAL SOFTENING.

As a consequence of several of tlie conditions described
in the foregoing pages, and especially as resulting from
thrombosis and embolism, cerebral softening naturally
comes next in order for consideration. Most authors treat
of it in direct connection with obliteration of the cerebral
arteries, but, although frequently due to this cause, it may
be produced by others, and occlusion is not always followed
by softening. For these reasons I have preferred to con-
sider it as it really is, a distinct pathological condition — as
much so as sclerosis or any other morbid anatomical state.

Symptoms. — When softening is the result of haemorrhage,
thrombosis, or embolism, the symptoms peculiar to those af-
fections are first met with. Thus there are troubles of the
intelligence, the sensibility, and the power of motion, such
as have already been described under the heads mentioned,
and, if the morbid process goes on within the cranium, there
are peculiar aggravations and the development of new symp-
toms. The condition of softening is not set up after either
haemorrhage, thrombosis, or embolism, till about the tenth
day, and the symptoms now to be mentioned are those
which are coincident with what some pathologists have
designated the " second stage ; " the " yellow softening " of
others.

In addition to the continued paralysis of motion and the
loss of sensibility which exist on one side of the body, the
mental symptoms become more strongly marked. There

138

DISEASES OF THE BRAIN.

may be delirium with the occurrence of hallucinations and
delusions, though these are generally evanescent. Occa-
sionally a fixed idea obtains possession of the patient's mind,
and for a while influences him in his conduct, but his men-
tal tenacity is not strong enough to enable him to retain it
for any length of time, so it soon yields to another.

The intelligence is notably diminished, so that the pa-
tient is unable to conceive an exact idea of his situation, or
to obtain a moderately complete notion of quite simple
matters which may be submitted for his mental action.
Thus he refuses to credit the assertion that he is ill, declares
that his health, both in mind and body, is excellent, and
that he is fully capable of transacting his business or of per-
forming any intellectual operation.

The memory is invariably impaired, and things of the
greatest familiarity are forgotten. Thus a patient laboring
under cerebral softening, the result of embolism, could not
tell his wife's name, nor by what means he came to my
office. Another, sent to me by Dr. Michel, of St. Louis, in
whom thrombosis was the probable cause, could not tell me
where he came from, nor the names of his children. He in-
sisted with great vehemence that he was perfectly able to
attend to his ordinary business, and yet was unable to add
three numerals together.

In another case, likewise having the clinical history of
thrombosis, which I saw in consultation with my friend Dr.
J. W. Eanney, of this city, the patient, a gentleman of
about sixty years old, could not tell his age ; declared that
Dr. Ranney, whom he had known for many years, was a
grocer, " who lived around the corner ; " and held to the de-
lusion that his sons had made several forcible attempts to
rob him.

The power of giving the attention to subjects is very
greatly lessened. The patient may seem to be listening to
what is said, or observing what is passing about him, but, if
he be questioned he at once, shows that he really has not

CEREBRAL SOFTENING.

139

been heeding ; even when things are forcibly brought to his
mind, and he is told to mark them, he is incapable of doing
so to any considerable extent.

The speech is almost invariably affected either in the
form constituting aphasia, or from paralysis of the tongue
and other muscles concerned in articulation. There is a
disposition to misplace words, or to clip them by cutting off
the last syllable. Thus a patient reading the title of a book
in my library called it the " Unit. Stat. Dispenst." for
United States Dispensatory; another was. the " Philosoph.
as Absol. Scien." for Philosophy as Absolute Science ; and
he told me he was " a lawy. by professi.," when he meant
to say he was a lawyer by profession. The same fault
is shown in reading from a printed page, and in writing.
Only a few days ago I received a letter from a gentleman,
in which the final letter of nearly every word was omitted.
The emotions, especially those of a sorrowful character,
are very easily excited, and therefore the least untoward
event causes the exhibition of feeling. Sometimes the pa-
tient sheds tears without being able to assign any cause,
or may get into uncontrollable fits of weeping ; occasionally
of laughing.

All these symptoms indicate failure of the mental power,
but it is, nevertheless, true that softening of the cerebral tis-
sue may exist without the manifestation of the least degree
of imbecility. It not unfrequently happens that, while there
is a general loss of intelligence, some one or two faculties of
the mind are notably increased in vigor.

I have a patient now under my charge whose intellectual
force is greatly reduced, who cannot pronounce the simplest
sentence correctly, who is paralyzed throughout the whole
of one side, and who has so lost the sense of propriety that
if he feels the desire to urinate he yields to it at once, no
matter where he may be or who are present, but whose voli-
tional power is even greater than before the accession of his
disease. Thus he will read volume after volume, turning

140

DISEASES OF THE BRAIN.

over the pages regularly, and scarcely, except by oversiglit,
skipping a word, although it is very certain he does not
comprehend a tenth part of what he reads, and that what he
does for the moment understand is immediately forgotten.
The strength of his will is also shown in the impossibility
of inducing him to do any thing which either caprice or
habit prompts him not to do. His appreciation of harmony
has become so sensitive that a discord of sounds made on the
piano causes him real mental sufFerring, whereas when he
was in health his musical taste and discrimination of the
pitch and quality of sounds were below mediocrity.

Drowsiness is very generally present ; at first, perhaps,
to a slight extent, but sooner or later as a prominent feature.
Headache is very common, and is usually dull and circum-
scribed. The forehead is its most common seat. Other
sensations in the head, such as vertigo, fulness, weight, and
constriction, are scarcely ever absent.

Gradually, the condition of the patient, mentally and
physically, becomes weaker and weaker, and death ensues,
immediately preceded by coma, convulsions, delirium, or a
combination of these phenomena,

ITot unfrequently, softening of the brain is not preceded
by haemorrhage, thrombosis, embolism, or other evident
affection, but begins obscurely, and advances very gradually.
In this form the symptoms previously described make their
appearance in succession ; but the paralysis, instead of being
present from the inception, comes on very slowly, commen-
cing as a slight weakness, conjoined with numbness, in one
or more of the extremities, or in the face. Ordinarily, the
first evidence of paresis is discovered in the leg, which is not
lifted clear of the ground. The toe consequently strikes
against the inequalities of the pavement, and the patient is
apt to fall. Sometimes the weakness is shown by the leg
suddenly giving way at the knee. I have had several pa-
tients with cerebral softening, in whom this accident was of
common occurrence, and who had thereby received severe

CEREBRAL SOFTENING.

141

injuries. Or, when tlie arm is the paretic member, the
grasp, as shown by tlie dynamometer, is materially lessened
in strength, and things held in the hand are dropped. I
have now a patient in charge in whom the affection is in its
very earliest stages, and of which the only manifestations
are, clipping of the words in speech and paresis of one arm.

This inability of the muscles to maintain a continuous
contraction for a short time, though met with in several
other affections, is to some extent characteristic of cerebral
softening, and, in conjunction with the other phenomena, is
a valuable indication. Even before it has become so far
developed as to attract the attention of the patient or those
about him, its existence may be ascertained by means of the
dynamograph described in the preliminary chapter of this
treatise. It will often be found that a straight line cannot
be made, but that the pencil pursues a zigzag course, or
else one descending with more or less regularity.

The paralysis usually goes on to complete loss of power,
though its progress is often very slow, and is marked occa-
sionally by periods of decided improvement. At these
times the patient's friends imagine that he is about to re-
cover, and if, as is sometimes the case, the mental symptoms
are likewise mitigated, their hopes are still further exalted.
It is necessary that the physician should not be deceived.
In a case which I saw in consultation with Dr. Chamber-
lain, of this city, I diagnosticated chronic softening. At
the time, there were feebleness of memory, paresis of one
side of the body, and difficulties of speech. I gave an un-
favorable prognosis, but soon afterward amendment began,
and the patient, who was an insurance agent or appraiser,
resumed his business to some extent. I nevertheless adhered
to my opinion, for I had seen too many cases of similar char-
acter to be deceived in so clear a one as this. I never saw
the patient again, and am therefore unacquainted with the
subsequent phenomena, except that about a year afterward
I was invited by Dr. Chamberlain to be present at the post-

142

DISEASES OF THE BRAIN.

mortem examination. His brain contained a foyer of soft-
ened tissue as large as a walnut, apparently the result of
obliteration of the posterior branch of the left middle cere-
bral artery, and involving a portion of the middle lobe of
the left hemisphere.

In another case, which I had very thorough opportu-
nity for studying, the patient, a gentleman thirty-five years
of age, was the subject of chronic softening, without any
history of previous lesions. The disease had come on very
insidiously, first showing itself by a slight impediment of
speech and impairment of memory. Gradually he lost
power in both arms and both legs, though the right side was
more affected than the left. His gait became titubating,
and although he never lost the ability to walk, yet he did
so with great and increasing difiiculty. But his stages
of apparent improvement were at first numerous and well
marked. His memory at such times was stronger, his coun-
tenance brighter, his articulation distinct, his emotions more
under command, his power of attention increased, his in-
telligence equal to all ordinary occasions, and his walk free
from any sign of debility. Then all these steps would be
suddenly lost, and he would again become imbecile and
weak. Finally, a severe convulsion, more evident on the
right side than the left, supervened one evening after din-
ner, as he was quietly smoking a cigar. Between seven and
twelve o'clock that night he had over a hundred fits. He
died at the latter hour. The post-mortem examination re-
vealed the existence of a large centre of softening, involving
the middle lobe of the left hemisphere.

Sometimes the course of the disease is still more irregu-
lar. No evidence of cerebral disorder is perceived beyond
aphasia, and the patient remains in the full possession of his
intellect, and without paralysis, up to a short time before
death. Durand-Fardel ' cites the case of a man, thirty years
of age, who entered the Hotel Dieu, presenting all the signs
' Traits du Ramollissement Cerebral, Paris, 1843.

CEREBRAL SOFTENING.

143

of pulmonary phthisis. In a few days afterward he experi-
enced difficulty of articulation, in thirty hours he became
comatose, and, in twenty more, died. The post-mortem ex-
amination revealed the existence of softening of the inferior
surface of the left middle lobe of the cerebrum. Although
it is not so stated — Durand-Fardel having written previously
to Yirchow's observations — there is little doubt that the
cause of the softening was an old embolus in the left middle
cerebral artery.

Lallemand,' in his first letter, cites several cases in which
the disease was marked by singular symptoms, such as con-
vulsions, contractions, and delirimn.

In a case which I saw in consultation with Prof. C. A.
Budd and Dr. J. T. Taylor, occurring in a gentleman about
thirty-five years of age, there were coma and violent hemi-
convulsions, evidently due to softening from embolism, of
which there had been two attacks, the last several weeks
previously. Death ensued, but no post-mortem examination
was, I believe, obtained.

A gentleman is now under my charge who has valvular
disease on the left side of the heart, the consequence of rheu-
matic endocarditis, and who, six months since, had an apo-
plectic attack conjoined with aphasia and right hemiplegia.
He soon became able to speak pretty well, and regained
power and sensibility to a great extent in the paralyzed
limbs. During the past two weeks, however, he has exhib-
ited symptoms of mental derangement, as shown by the
existence of hallucinations and delusions, and is gradually
losing the power of motion and of sensation on the right
side. His speech is as perfect as it ever was, and there is
yet no sign of dementia.

It has happened that individuals have died who, on post-
mortem examination, were found to have softening of the
brain, but who, during life, had exhibited no symptoms of

' Recherches Anatomico-Pathologiques sur I'Encephale et ses Dependances,
Paris, 1824.

14i

DISEASES OF THE BRAIN.

this or any other cerebral disorder. Kostan, who was the
first to write systematicallj on the disease, refers to such
cases, and Durand-Fardel is still more explicit. The latter
says :

" We meet with softening of the brain in persons who, up
to the time of death, had presented no appreciable derange-
ment of the cerebral functions, and in whom softening has
been developed without having given any evidence what-
ever of its existence." In such instances the white matter
of the hemisphere can alone be involved.

One such case verified by post-mortem examination has
occurred within my own experience. The patient, a soldier
of the Second United States Infantry, died at Fort Riley,
in Kansas, of which post I was the medical ofiicer, of chronic
dysentery, the result of exposure. There were no mental
symptoms, no difficulty of speech, no paralysis ; nothing, in
fact, indicating the existence of brain-disease. He died in
full possession of his intellectual faculties. The post-mortem
examination revealed the existence of ulceration of the small
intestines, and, as the cause of death was very evident, the
brain was not examined. I reserved it, however, for pur-
poses of study, and, on making a section of the right hemi-
sphere an hour afterward, discovered an encysted centre of
softening including more than two-thirds of the posterior
lobe. The right posterior cerebral artery was entirely ob-
literated by thrombosis. The man had been at the fort for
several months, and had never made complaint of any illness
till he was attacked with dysentery six weeks before.

The duration of cerebral softening is very variable.
Rostan found it to range from a few days to several years.
Andral, from an analysis of one hundred and five cases,
found that the period was from twelve days to three years.
The most rapid case occurring in my experience terminated
in death at the end of eighty hours. Some confusion on this
point has arisen from the fact that some authors regard em-
bolism and thrombosis as essentially identical with soften-

CEREBRAL SOFTENING.

145

ing, a doctrine which is clearly erroneous, as, in many cases
of these affections, recovery or death may take place with-
out the stage of softening being reached. In the case above
referred to, post-mortem examination showed that the condi-
tion known as yellow softening was just making its appear-
ance. As I have already stated, I cannot regard the altera-
tion called by some pathologists red softening any thing
more than the congestion due to the active collateral circu-
lation.

The case of longest duration, of which I have any per-
sonal knowledge, was that of an eminent scientific gentle-
man, who had suffered from the symptoms of softening of
the brain for nearly four years, when he died. There was
no post-mortem examination, but the history of the case was
that of thrombosis of the left middle cerebral artery, and the
course of the disease left no room for doubt as to its na-
ture.

"When death results, it may be directly due either to the
disease itself, or to some intercurrent affection. Thus the
patient may die from pure exhaustion or from slow asphyxia
caused by the imperfect action of the respiratory function, or
he may choke to death either by being unable to swallow
food which he has taken into his mouth, or by the regurgi-
tation of the contents of the stomach during a convulsion,
or a severe convulsive seizure may cause immediate as-
phyxia, or a series of convulsions may produce a more grad-
ual asphyxia, or he may die in a state of profound coma.

The intercurrent affections may be either meningitis or
hypostatic congestion of the lungs from long confinement to
the recumbent posture, or diarrhoea, or a fresh attack of
thrombosis or embolism.

Causes. — The etiology of cerebral softening has already
been considered to some extent under the heads of cerebral
haemorrhage, thrombosis, and embolism, of which condi-
tions it is so often a sequence ; but, as it frequently occurs
without having been preceded by either of these or other
10

146 DISEASES OF THE BRAIN.

noticeable affections, a few additional observations are ne-
cessary.

Age is certainly a strong predisposing, if not an actual
existing cause, althougb the disease is observed at all periods
of life. Eostan, whose cases were collected at the Salpe-
triere, a hospital containing only old women, found that
there were ten cases in persons between the ages of sixty
and sixty-nine, twenty between seventy and seventy-nine,
and ten between eighty and eighty-seven. Andral, exclud-
ing cases occurring in infants, found that, of one hundred
and fifty-three cases, there were between the ages of

15 and 20 10

20 " 30 18

30 » 40 11

40 " 50 19

50 " 60 27

60 " 70 34

70 " 80 30

80 " 89 4

Durand-Fardel, from an analysis of fifty-five cases, found
between the ages of

30 and 40 3

40 " 50 8

50 " 55 2

60 » 70 14

70 " 80 23

80 " 87 5

The period of life, therefore, at which softening is most
apt to occur, is from the age of fifty to eighty.

During the past six years twenty-eight cases of cerebral
softening, not the result either of hsemorrhage, thrombosis,
or embolism, have been under my care or been seen by me
in consultation. Of these one was under twenty years of
age, three were between twenty and thirty years ; four be-
tween thirty and forty ; four between forty and fifty ; six

CEREBRAL SOFTENING.

14Y

between fifty and sixty ; eight between sixty and seventy ;
and two between seventy and eighty. The general results,
therefore, go to show the greater proclivity which advanced
age gives to the occurrence of the disease. In one of those
between seventy and eighty, the mind was scarcely impaired
till about two months before death, though there had been
paresis, headache, and aphasia, for two years.

No definite statistics have been collected relative to the
influence of sex, although the opinion appears to prevail
that the affection is more liable to occur in females than
in males. Of the twenty-eight cases just cited, twenty were
males and eight females.

The season of the year does not appear to exercise much
influence. Durand-Fardel, from sixty-three cases, found
that seventeen occurred in winter, thirteen in spring, twenty
in summer, and thirteen in autumn. I have found it diffi-
cult in many cases, from the insidious or latent character of
the early symptoms, to fix the period of beginning with ac-
curacy.

Intense and long-continued intellectual exertion is one
of the most common causes of cerebral softening. Eleven
of the cases occurring in my experience were clearly the re-
sult of this cause. Severe and protracted emotional disturb-
ance was apparently the cause in four cases.

Rostan, among the causes, cites insolation, the action of
intense cold upon the head, blows, and excessive use of alco -
holic liquors.

The influence of thrombosis and embolism in producing
partial cerebral anaemia, and hence as leading to the super-
vention of softening, has already been dwelt upon at suffi-
cient length.

Diagnosis. — The history of hgemorrhage, thrombosis, or
embolism, when these afiections have either of them given
rise to softening, will aid in the diagnosis. The signs which
serve to distinguish these affections from others have already
been sufficiently considered.

148

DISEASES OF THE BRAIN.

"When there is no sucli previous clinical history, softening
of the brain may be confounded with chronic meningitis,
meningeal hsemorrhage, or tumors. From chronic menin-
gitis it is to be distinguished in many cases by the facts that
in the former the headache is generally diffused, while in
softening it is fixed, that the paralysis is more limited, that
there are frequent spasms of the limbs, that there are well-
marked febrile exacerbations, and that there is not the pro-
gressive enfeeblement of the intellect so characteristic of the
vast majority of cases of cerebral softening. At the same
time it must be admitted that the diagnosis sometimes can-
not be clearly made out.

In meningeal haemorrhage coma occurs as an early symp-
tom, gradually increasing in intensity, whereas in softening
it comes on at a late period. Hsematoma of the dura mater,
however, may readily be confounded with softening. The
history of the case will aid in the formation of a correct di-
agnosis.

In tumors the most prominent symptoms are pain and
convulsions, while the intellect usually remains unaffected.
The pain is exceedingly intense, while in softening it is dull.
The speech in tumors is generally unaffected.

Prognosis. — Cerebral softening in general ends in death.
!Nevertheless, it is not altogether hopeless. If the patient
be young, of good constitution, and of temperate habits ; if
the centre of softening be small, and not involving the more
important parts of the brain, there is some encouragement
to expect a favorable termination. Some of the cases cited
in this chapter go to show that recovery is possible, and I
have certainly seen others with the ordinary initial symp-
toms of cerebral softening recover with appropriate medica-
tion. Such patients, however, were all under the age of
forty, and were of good constitution and habits. In soften-
ing due to embolism, and occurring after rheumatism and
endocarditis, the liability to future attacks must not be over-
looked. I have seen as many as six attacks of embolism oc-

CEREBRAL SOFTENING.

149

cumng in the same patient, and yet no morbid condition
beyond that of anaemia set up, and again cases in which a
single embolus has caused softening and death.

Morbid Anatomy. — In the softening of the brain which re-
sults from thrombosis or embolism, the first stage after that
of congestion from the excessive action of the collateral cir-
culation is what is called yellow softening. This is not, as
some authors have supposed, produced by the infiltration of
pus into the cerebral substance, but is caused by regressive
metamorphosis of the brain-cells into fat, the granules of
which are mixed with the coloring matter of the blood which
gives rise to the peculiar yellow color. The white corpus-
cles of the blood also undergo degeneration into fat.

These altered white corpuscles were described by Gluge *
as inflammation corpuscles, under the idea that softening
was always the result of inflammation. Laborde,^ who has
studied this subject with great success, shows, however, very
conclusively that the transformation is a true degeneration,
a part of the fat-corpuscles being derived, as stated above,
from the nervous fibres, the cylinders of which disappear,
the contents being extravasated, and with the myeline being
converted into fat ; and another part consisting of altered
white blood-corpuscles. At this time the cerebral tissue is
pulpy, constituting a centre of softening or foyer ^ the con-
sistence of which is greater at the circumference than at the
centre. The blood-vessels passing through the disorganized
portion are easily separated from the perivascular tissue and
are covered with oil-globules.

The second stage is designated white softening, and in it
the brain-substance loses altogether its morphological char-
acteristics, and appears as a white, cream-like matter so soft
that a weak stream of water, allowed to impinge upon it,
washes it away. In this semi-liquid matter, whitish flakes
of denser tissue are suspended. Microscopical examination

' Atlas of Pathological Histology. Translated by Leidy. Philadelphia, 1853.
2 Op. cit.

150

DISEASES OF THE BRAIN.

shows that all traces of nervous structure have disappeared,
and that no anatomical elements remain except oil-glob-
ules and organic corpuscles somewhat resembling leuco-
cytes.

When the morbid process involves the cortical substance
of the cerebrum, the convolutions undergo a peculiar kind
of transformation first pointed out by Cruveilhier, and then
by Durand-Fardel ' as occurring in the senile form of soft-
ening.

This is characterized by the formation of yellow plates,
irregular in form, soft to the touch, but yet sufficiently dense
to resist the action of a thin stream of water. Microscopi-
cally they are seen to consist of nucleated fibres, fat-corpus-
cles, fat-globules, and degenerated capillaries, with blood-
crystals and granular matter. Essentially, therefore, they are
formed of connective tissue.

The degenerated nerve-tissues, constituting a focus of
softening, may undergo absorption. In such a case, a cica-
trix, similar in general characteristics to that resulting from
the curative process of haemorrhage, remains.

In the softening resulting from inflammation, a somewhat
difierent set of morbid appearances exists. Thrombosis and
embolism produce a true death of the parts previously sup-
plied by the occluded vessels, a necrobiosis, as it has been
called by Yirchow. The process is accompanied, as we have
seen, by degeneration of the nervous tissue, but in the soft-
ening due to inflammation new formations result. Some-
times the two coexist, but the latter is occasionally an en-
tirely independent action.

When such is the case, connective tissue is generated,
and the nervous substance is rapidly broken down. An ex-
udation of an albuminous fluid containing fine granules, the
disintegrating nervous substance and numerous flakes of co-
agulated fibrine, takes place, and with blood-corpuscles causes
the centre of softening to present the appearance of a red-

' Maladies des Vieillards. Paris, 1854, p. '72.

CEREBRAL SOFTENING.

dish pultaceous mass, easily washed away by the action of a
weak stream of water. "With age the color of this softened
tissue becomes brown or yellow. Sometimes, when the in-
flammation has extended to the deeper parts of the cere-
brum, the contents of the cyst are penetrated by the new
connective tissue. The pulpy mass undergoes partial ab-
sorption, and is replaced by a white turbid liquid, called by
Cruveilhier and Dechambre " milk of lime " (lait de chaux).
Durand-Fardel designates this form of softening " cellular
infiltration."

The softening resulting from occlusion of the capillaries,
a condition not recognizable during life, does not differ es-
sentially, except in its situation, from that which follows
thrombosis or embolism. The centres of the process are,
however, smaller, and are generally numerous.

When disease of the capillaries has been the cause of the
softening, these may be ruptured, and we meet with minute
extravasations of blood in the disintegrated perivascular
tissue constituting the " capillary hasmorrhage " of Cruveil-
hier.

Pathology. — The first definite accounts of cerebral soften-
ing were given by Lallemand * and Eostan,* both of whom
published their works in the same year, 1820.

In the very beginning of his first letter, Lallemand awards
to MM. Recamier, Bayle, and Cayot, the credit of describing
the condition under consideration, and of giving it the desig-
nation by which it is so generally known, even out of France,
of ramoUissement. Lallemand then proceeds to define the
term by saying that, by ramoUissement of the brain, he under-
stands a kind of liquefaction of a part of its substance, the re-
mainder preserving its ordinary consistence. He then quotes
cases from Morgagni and Abercrombie, and cites others from
his own experience ; and then concludes by declaring that he

' Recherches Anatomico-Pathologiques sur I'Encephale. Paris, 1820.
' Recherches sur le RamoUissement du Cerveau. Paris, 1820. My refer-
ences to Rostan's work are to the second edition, of 1823.

152

DISEASES OF THE BRAIN.

does not hesitate to range cerebral softening among the in-
flammations, in which opinion he is supported by Abercrom-
bie.* Rostan " regarded the disease as sometimes being due
to inflammation, and sometimes to degeneration of the
blood-vessels. Bouillaud * viewed it as an anatomical fea-
ture of inflammation. Cruveilhier* considered what he
called red softening as resulting from the caj)illary haemor-
rhage previously mentioned, and that other forms were cer-
tainly due to inflammation.

Andral ^ recognized the fact that softening might result
from inflammation or capillary haemorrhage, but he also in-
sisted that it might be due to special alterations of nutrition,
caused by difierent morbid influences, such as obliteration
of the arteries supplying the brain, or impoverishment of
the blood.

MM. de la Berge and Monneret* adopted in part the views
of Eostan relative to degeneration of the cerebral vessels as
a cause of softening. Carswell ^ regarded softening occur-
ring during life as being effected by these circumstances —
inflammation, obliteration of arteries, and modiflcation of
nutrition.

Fuchs * appears to think that inflammation is not a ne-
cessary antecedent, but that congestion is. He also admits
obstruction of the arteries at the base of the brain to be a
cause.

The studies of Durand-Fardel * have been very thorough,
and have contributed greatly to our knowledge of cerebral
softening. According to him, the affection is an inflamma-

1 Op. cit., p. 205. 2 Op. cit., Chapter VII.

s Traite de I'Encephalite. Paris, 1825.

* Art. Apoplexie, in Dictionnaire de Medecine et de Chirurgie Pratique.
^ Clinique Medicale.

* Compendium de Medecine Pratique.

' Art. Softening of Organs, in Cyclopaedia of Practical Medicine, vol. iv., p.
176, American edition.

8 Beobachtungen und Bemerliungen iiber Gehirnerweicliung. Leipzig, 1838.

* Traite du Ramollissement du Cerveau, Paris, 1843,

CEREBRAL SOFTENING.

153

tion which does not differ essentially from other inflamma-
tions occurring in the young or old. White softening he
regards as the chronic form of the disease.

Other pathologists published the results of their obser-
vations and generally to the same effect as those which have
been quoted, viz., that cerebral softening was an inflamma-
tory process, and sometimes one resulting from obliteration
or disease of the arteries. A few, however, held to the view
of Lallemand and Durand-Fardel, that inflammation was
always the starting-point.

In 184T Yirchow published his observations relative to
embolism, and the partial cerebral anaemia produced by oc-
clusion of an artery thus became a recognized fact. In
reality, it came to be regarded as the only cause capable of
giving rise to softening, and many pathologists of the pres-
ent day entertain such aii opinion. But I think this is car-
rying the theory further than facts will warrant. I can-
not altogether disregard the researches of Durand-Fardel,*
Calmeil,^ Rokitansky,' Wedl,* and others, and although I
cannot agree that all cerebral softening is a consequence of
inflammation, I am very sure it has this and other causes
besides thrombosis and, embolism. Calmeil's work is a mon-
ument of careful observations and scientific deductions, and
his fifth chapter (t. ii.), entitled " Du Ramollissement cere-
hral local aigu^ ou de V Encephalite locale aigue sans caillots
sanguins siegeant sous la forme d'un foyer ou des plusieurs
foyers circonscrits, soil d la surface^ soil dans la jprofon-
deur de la masse encejyhaligue^'' contains cases which are
amply suflScient to establish the point for which he contends.
He shows, too, in other chapters of his treatise, that soften-
ing results about the periphery of clots due to cerebral haem-
orrhage.

* Maladies des Vieillards, Paris, 1854.

' Traite des Maladies Inflammatoires du Cerveau, Paris, 1859.

* Pathological Anatomy, Sydenham Society, translation, 1850.

* Rudiments of Pathological Histology, Sydenham Society, translation, 1855.

154

DISEASES or THE BRAIN.

The weak feature of Calmeil's otherwise very complete
work is, that he altogether ignores Yirchow, and those after
him, who have confirmed his facts and theories.

Soulier,' on the other hand, can see in softening nothing
of the nature of inflammation. For him it is always a ne-
crobiosis, produced by the cessation of the physiological ac-
tion of the blood, obliteration by embolus or thrombus, by
diminution of the calibre of the vessels, or occlusion result-
ing from atheroma or obstruction of a vein or sinus. He
admits that the obliteration of an artery may cause conges-
tion behind the point of obstruction, by which the coagula-
tion and capillary hemorrhage of acute softening — the capil-
lary apoj)lexy of Cruveilhier — are to be explained. This
red ramollissement has, however, nothing of the nature of
inflammation about it.

The only points in which I differ with Soulier are, that
I cannot regard softening as being solely due to occlusion
of blood-vessels, and that I am very sure the congestion
which follows thrombosis or embolism is not necessarily the
first stage of softening. There is no more reason why par-
tial cerebral anaemia should always result in softening, than
that ligation of the femoral artery .should always lead to
gangrene of the parts below.

Obstruction of veins and sinuses in the brain may be fol-
lowed by softening. The clot is usually the result of inju-
ries or disease of the cranial bones or cerebral membranes,
especially the dura mater. It may also be caused by cer-
tain cachectic conditions in which the blood is deteriorated
in quality, such as typhus and typhoid fevers and cholera.

Four cases, in which this latter affection was followed by
thrombosis of the superior longitudinal sinuses, with consec-
tive softening, have come under my observation. In two of
them there were also thrombi in both femoral veins. The
upper surfaces of both hemispheres were the seats of the
softening, which involved the gray matter only,

' Journal de M^decine de Lyon, Fevrier, 186Y.

CEREBRAL SOFTENING.

155

Thrombosis of the veins or sinuses may also in general
terms be produced by whatever cause is capable of retard-
ing the current of blood. Mr. Toynbee/ in his chapter on
diseases of the mastoid cells, has brought forward several
cases in which the lateral sinus was occluded by coagula,
and in which there was cerebral softening.

Cerebral softening may also result from the formation of
adventitious growths, or from the presence of foreign bodies
in the brain. In such cases the process begins with inflam-
mation, and is similar to the action which sometimes goes
on around an extravasation of blood.

Acute cerebritis or meningitis may likewise result in soft-
ening. This fact is admitted by Drs. Russell Reynolds and
Bastian, in their admirable essays on cerebritis and softening
of the brain, though with evident reluctance.

We see, therefore, that cerebral softening may be caused
either by anaemia or inflammation, and that it is of two
kinds, inflammatory and non-inflammatory. The seat of
the softening may be in any part of the brain, although
some regions are more liable than others. When due to
thrombosis, there appears to be no predilection for any par-
ticular location, but, as embolism is generally found on the
left side in the middle cerebral artery, the jDarts of the brain
supplied by this vessel are more liable than the correspond-
ing parts of the right side.

Durand-Fardel, however, did not arrive at this conclu-
sion. Of one hundred and sixty-nine cases of softening, he
found the left hemisphere the seat in sixty-nine, the right in
seventy-one, both in twenty- six, and the middle line in
three.

The gray matter is generally supposed to be more fre-
quently the seat of softening than the white. It is true that,
of thirty-three cases of acute softening observed by Durand-

* The Diseases of the Ear, their Nature, Diagnosis, and Treatment : London,
1860.

156

DISEASES OF THE BRAIN.

Fardel/ the convolutions were involved in thirty-one, but
in nine only were they the sole part affected.

In fifty-three cases which the same author collected from
the writings of Eostan, Lallemand, and others, the centres
of softening were found to be as stated in the following table.
Occasionally more than one region was involved.

Convolutions and white substance 23

Convolutions alone 6

White substance alone 5

Corpus striatum and optic thalamus 6

Corpus striatum alone 11

Optic thalamus alone 4

Pons Varolii 3

Crux cerebri 1

Corpus callosum 1

Walls of the ventricles (septum) 1

Fornix 1

Cerebellum 1

Bastian," has therefore erred in citing these statistics as
showing the greater liability of the convolutions; for in
six cases only were the convolutions the sole seat of the dis-
ease.

Rostan, on the other hand, found the corpora striata,
around the optic thalami, to be the parts most frequently
affected, and after these the central part of the hemispheres.
He met with but few cases involving the median line.

As regards the frequency with which the convolutions
with the white substance were involved, as compared with
the motor tract, he found that, of one hundred and seventy-
seven cases of acute and chronic softening, the convolutions
were affected in one hundred and nineteen, and the corpora
striata and optic thalami in fifty-eight.

The middle lobe is more liable than any other, as is seen
in the following statement of Durand-Fardel, based upon an
analysis of ninety-five cases :

' Traits du RamoUissement du cerveau, Paris, 1843. 2 Op. cit.

CEREBKAL SOFTENING.

157

Posterior lobe 18

Middle 51

Anterior 13

Posterior and middle 7

Posterior and anterior 3

Middle and anterior 2

Whole convexity of hemisphere 1

^RGddle line 1

In more than one-half of the cases, therefore, the middle
lobe was the seat of the disease.

A question connected with the pathology of cerebral
softening, as with haemorrhage, is. Can we determine, from a
consideration of the symptoms, what part of the brain is the
seat of the lesion ? The answer must be the same. We can
do so with some approach to accuracy, but, till we are better
acquainted with the physiology of the different ganglia com-
posing the brain, we cannot expect to do so with absolute
certainty. Indeed, owing to the greater extent of tissue in-
volved, compared to that affected in hsemorrhage, we have
a more complicated set of phenomena to deal with. I have
nothing further to add to the remarks made on a similar
point, under the head of cerebral haemorrhage.

Treatment. — The treatment proper for cerebral softening
should depend very much upon the cause from which it has
arisen, and must more or less be directed against the symp-
toms which are manifested. Thus, if there is reason to sus-
pect the existence of thrombosis or embolism, and a con-
sequent anaemic condition of a portion of the brain, the judi-
cious use of stimulants and tonics is advisable, while the
body should be kept warm by additional clothing, or the
application of artificial heat — at the same time the recum-
bent posture should be assumed, and the head supported on
a low pillow. Mental exertion should, of course, be ab-
solutely interdicted. If there be much headache, it is prob-
ably due to too great an activity of the collateral circulation,
and in such a case some one of the bromides may be given

158

DISEASES OF THE BRAIN.

in large doses, repeated as often as may be necessary. I
have frequently seen great relief follow their administration.

Delirium is often due to a like cause and may be similar-
ly treated. Dr. Eeynolds ' speaks highly of the Indian hemp
in doses of a quarter to half a grain of the extract ; but, I
have found the bromide of potassium, in doses of thirty grains
every three or four hours, more efficacious.

It is also the most beneficial remedy in the convulsions
which frequently precede a fatal termination.

In that form of softening which is obscure in its origin
and gradual in its progress, there is a little more hope of a
favorable result, though even here it must be confessed that
treatment is not often efiectual. Still, as I have said, when
speaking of the prognosis, there are undoubtedly cases in
which recovery has taken place, and I am very sure that I
have several times succeeded in curing individuals who, so
far as I have been able to judge, were affected with cerebral
softening. As these cases are interesting in themselves, and
as the histories will show the means of treatment employed,
I do not hesitate to transcribe the following typical ones
from my case-book :

I. — Mr. R., a gentleman, twenty-four years of age, awoke
one morning about the middle of March, 1870, with a sen-
sation of numbness extending through the whole of the left
arm and leg, and with a feeling of vertigo which was insup-
portable when he arose from the bed. He sat down in a
chair, and while in this position was conscious of a buzzing
sound in the right ear. In the course of half an hour the
vertigo passed off, but the numbness and sound in the ear
remained, and he occasionally saw double. In a few days
afterward he noticed a slight difficulty of articulation, owing
to apparent thickness of the tongue, and about the same
time observed that in the morning the pillow was wet with
the saliva which had run from his mouth during sleep. His
uncle, a wealthy gentleman of this city, sent him off travel-
' Article, Softening of the Brain, in System of Medicine, vol. ii.

CEREBRAL SOFTENING.

159

ling, but lie returned in a few weeks with loss of power in
the left arm and leg, which had begun to be manifested to a
slight extent before his departure. He came under my
charge May 15, 1870.

At this time the paralysis, of both motion and sensation,
was well marked on the left side, as shown by the sesthesi-
ometer and dynamometer. The line made by the dynamo-
graph with the right hand was perfectly straight, while that
made by the left was at an angle of forty- five degrees with
the other. In his conversation he clipped his words, and
sometimes left out the smaller ones. His memory he stated
was materially impaired. There was almost constant head-
ache over the whole frontal region, and attacks of vertigo
were frequent. There was no marked paralysis of the face,
though the muscles of both sides were paretic, and he often
had double vision. The right pupil was largely dilated and
was insensible to light.

Ophthalmoscopic examination showed the left eye to be
perfectly normal, but the retinal vessels of the right were
smaller and straight, and the choroid was paler than nat-
ural.

Upon inquiry I ascertained that he had given extraordi-
nary attention to his business for a period of several months
before the attack of numbness, frequently being up making
calculations till three o'clock in the morning, and thus de-
priving himself of the necessary amount of sleep.

My opinion was, that he was suffering from incipient soft-
ening of the brain due to disease of the capillaries, which, in
its turn, resulted from cerebral congestion and exhaustion.
I was further of the opinion that the lesion involved the
right hemisphere and motor tract.

I prescribed the phosphide of zinc in the dose of the
tentli of a grain, with half a grain of extract of nux-vomica
in pill three times a day, with the constant galvanic current
three times a week, the latter to be derived from fifteen of
Smee's cells, and to be passed from forehead to occiput for

160

DISEASES OF THE BRAIN.

three or four minutes at a time. At the end of ten days he
had lost his diplopia, the pupil of the left eye had regained
its natural diameter and irritability, and the vertigo and
headache had notably diminished. The treatment was con-
tinued, and at the end of a month he had recovered the sen-
sibility and power on the paralyzed side to such an extent,
and had improved so much in other respects, that I advised
him to take a short journey. He was absent two weeks,
during which period he continued to take the pills as before,
and on his return was, to all appearance, well. He has since
remained in excellent health.

II. — Mr. R. "W., a merchant of this city, consulted me
in April, 1868, imder the following circumstances :

After a long period of great domestic anxiety, during
which he had been engaged in some heavy commercial
transactions, and had suffered from wakefulness, he expe-
rienced one afternoon, while riding in the park in his car-
riage, a slight quivering motion at the apex of the tongue.
It continued until he reached home ; and then, upon look-
ing in a mirror, he could see the fibrillary movement very
distinctly. He was not alarmed, and went to bed at his
usual hour. In the morning he noticed a little thickness
of speech, but the movement had ceased. That afternoon
he had a violent headache, attended with vertigo and nau-
sea. Becoming alarmed, he sent for his family physician,
who ascribed the symptoms to indigestion, and administered
a mild cathartic. The following day, on attempting to rise
from the bed to go to the water-closet, he was attacked with
such a severe vertigo that he was obliged to lie down again ;
and, though he did not for a moment lose consciousness, his
faeces escaped from him involuntarily. From this time he
gradually lost strength in both arms and legs, and his speech
became very defective. His memory suffered to such an
extent that he forgot the names of his children. There was
very little headache, the vertigo had ceased, there was no
disturbance of vision, and no loss of power over the sphinc-

CEREBRAL SOFTENING.

161

ters. About six weeks after the occurrence of the first symp-
tom noticed, he came under my care.

At this time there was anaesthesia of both sides of the
body, botli legs and both arms had lost power ; he clipped
his words, and frequently substituted others of similar sound
or meaning for those he ought to have used. His memory
was much weakened, and there was a strong tendency to
stupor. There were no troubles of the special senses —
ophthalmoscopic examination revealed nothing abnormal —
there was no facial paralysis. I diagnosticated softening of
the brain from general cerebral anaemia consequent upon
congestion and cerebral exhaustion, and I prescribed a lib-
eral allowance of wine, a full and nutritious diet, carriage
exercise, and amusements of various kinds. This was the
very reverse of the treatment to which he had been sub-
jected. In addition, I recommended the constant galvanic
current, to be applied as in the previous case, and gave the
following prescription: ]^. Oleii phosphorat. §ss; mucil.
acaciae, ^j? ol. bergamot gtts. xv. M. ft. emulsion.
Dose, gtts. XV. ter die.

The treatment was carried out with the result of obtain-
ing a gradual and permanent improvement, so that at the
end of about six months the patient was well. He then
went to Europe, where he now is, with as good health as he
has ever enjoyed.

Three other cases, similar in their general features, have
been under my care with a like result in each, and several
others have been very decidedly improved and relieved of
the more prominent symptoms of the disease without, how-
ever, regaining full health. The means of treatment thus
far consist in the use of tonics, stimulants, and especially
phosphorus and strychnine, the avoidance of all severe men-
tal exertion, and all excessive emotion, open-air exercise,
and the use of the constant galvanic current.

The beneficial effects of maintaining the physical
strength were several years since pointed out by Mr. F.
11

162

DISEASES OF THE BRAIN.

Skey ' in a clinical lecture delivered at St. Bartholomew's
Hospital, but it must be confessed that the opposite plan
of treatment has been very generally followed.

Softening from the effects of thrombosis or embolism is,
as I have said, not much under the control of the physician.
Patients recover from it, however, when they are of good
constitution, and when the focus of softening has not been
extensive. The mind and body may, and in such cases gen-
erally do, remain false, and we are therefore consulted for
the relief of the condition. In such cases tonics, and among
them phosphorus, strychnine, and wine, occujjy a prominent
place ; the constant galvanic current to the head, and the
induced to the paralyzed muscles, will rarely fail to be of
service.

III. — Thus a gentleman, who had been a distinguished
officer of the army, suffered from loss of memory, defective
articulation, ptosis, double vision, and right hemiplegia, prob-
ably the result of embolism. Several years before he came
under my charge, he had been treated by my friend Dr. J. T.
Metcalfe, for heart-disease, the result of acute rheumatism.
I gave the phosphide of zinc and extract of nux-vomica
according to the formula previously mentioned, advised a
liberal use of wine and beefsteaks, applied the primary
current to the brain, and the induced to his paralyzed arm
and leg, and in a few weeks had the satisfaction of seeing
such a degree of improvement as almost to constitute a cure.
The ocular troubles had disappeared, his memory had im-
proved, he talked as well as ever, and the numbness and
loss of strength were no longer remarked unless he over-
exerted himself, which, owing to his general feeling of hien
aise, he was very apt to do. He remained in this condition
for over a year, when he had several other attacks of embo-
lism, each of which left him more weak, mentally and physi-
cally, than before, and of which he eventually died.

1 On the Value of Tonic Treatment in some Diseases of the Brain, more es-
pecially cases of Ramollisseraent. Dublin Hospital Gazette, November, 1858.

CEREBRAL SOFTENING.

163

There were some interesting features connected with this
case, which will be referred to at greater length hereafter.

TV. — In another case, in which there was reason to think
2, foyer of softening had been absorbed, a marked relief from
the sequelae was obtained. The patient, a literary gentleman
of distinction, had, several years previously to my seeing
him, suffered from an attack of acute rheumatism with en-
docarditis. About a month after his recovery, as he was
sitting in his library before the fire, he felt a sensation as if
one side of his face had suddenly become much heavier than
the other. Almost immediately afterward he lost conscious-
ness, and fell to the floor. He could not have been in this
condition longer than five minutes when he came to him-
self, to find that he was paralyzed in the right arm and leg.
Attempting to call for assistance, he found he could not
articulate. His wife soon afterward entered the i-oom, and
medical aid was obtained. He was bled to the extent of
sixteen ounces, and purged with croton-oil.

The following day he was much better ; could move his
arm and leg, and articulate with some degree of distinctness,
but toward evening headache ensued, he became delirious,
and the paralysis increased. Of the condition immediately
following, he could give no very clear account. He only
knew that he was confined to his bed for several weeks, was
delirious part of the time, and that, after the acute attack
passed off, he was left with an enfeebled mind, imperfect
articulation, and paralysis of the arm and leg on the right
side. He went to Europe, travelled extensively, and re-
turned at the end of a year very much improved, but still
with some degree of mental weakness, defective speech, and
paralysis, remaining.

When he came under my observation, the following
were the principal symptoms observed : The strength of
the right arm, as measured with the dynamometer, was not
one-third that of the left ; the extensors of the leg and foot
were almost entirely paralyzed, so that in walking he ab-

164

DISEASES OF THE BRAIN.

ducted the leg so as to cause the foot to clear the ground •
electro-muscular contractility was much weakened, though
the induced current caused feeble contractions. His speech
was affected mainly as regarded the memory of words. He
spoke with a good deal of volubility, but constantly used
the wrong expressions. Thus, when he wished to tell me
that he had visited Europe for the benefit of his health, he
said : " I went to elope for the bequest of my hedge," and
then went on — continually making other mistakes — to tell
me a long story which I could scarcely understand. His
emotions were easily disturbed : he cried because he had to
wait a few minutes in my reception-room before seeing me.

Ophthalmoscopic examination showed pale choroids and
straight and attenuated retinal vessels. Auscultation re-
vealed the existence of both mitral and aortic regurgitation.

Taking into consideration the history of the case and the
present condition of the patient, I diagnosticated embolism
of the left middle cerebral artery, subsequent softening and
eventual absorption of the diseased part of the brain. My
idea was that the brain, as a whole, was anaemic, and that,
with improved nutrition of it and the paralyzed limbs,
amelioration of the symptoms was possible.

I therefore prescribed the phosphide of zinc and nux-
vomica pills as before mentioned, directed the use of wine
to the extent of half a bottle of champagne daily, and ad-
vised that animal food should form the principal portion of
each meal. Since his illness he had, by direction of his phy-
sician, left off the use of coffee. I directed it to be resumed,
and to be taken strong. The primary galvanic current was
passed through the head in the manner previously indicated
in this chapter, and the induced current was applied for half
an hour three times a week to the arm and leg, each para-
lyzed muscle receiving a full share of attention.

It was not long before signs of amendment were noticed.
His strength became greater in the arm, and he was able to
extend the leg and to raise the foot after half a dozen elec-

CEREBRAL SOFTENING.

165

trical applications. His speech next gave evidence of im-
provement, and his mind became stronger. The treatment
was continued for about four months, with only an inter-
mission of a week. At the end of that time his gait was
almost natural, though he still swung the foot a very little,
his arm was nearly as strong as the other, his mind was not
perceptibly weaker than that of other persons of his age
(fifty-five), and his speech was excellent except when he was
excited and very anxious to express himself correctly and
fluently.

There is one point in regard to which a few words are
perhaps necessary, and that is to enter a protest against the
use of counter-irritation of any kind, and to discountenance,
as far as I can, the employment of the actual cautery. I have
never seen the least advantage follow the application of cro-
ton-oil to the shaven scalp, nor can I conceive how such a
measure can be recommended on rational grounds. I have
several times witnessed its action, and have invariably seen
it aggravate the symptoms. In the case of a gentleman from
St. Louis, afiected with cerebral softening, the efiect was to
make his speech still more imperfect and his mind weaker.
A lady, wl\o was affected with all the more prominent symp-
toms of softening of the brain, had all the phenomena in-
creased in violence after the application of the actual cautery
to the nape of the neck. I could easily adduce other ex-
amples to the same effect, were it necessary.

CHAPTEE VII.

A PHA SI A .

The subject of aphasia is of such interest, and so much
attention has recently been given to it by physiologists and
pathologists, that, although it is only a symptom common to
several morbid conditions, a treatise on diseases of the ner-
vous system would scarcely be regarded as complete without
its being fully considered.

By aphasia is understood a condition produced by an af-
fection of the brain by which the idea of language, or of its
expression, is impaired. The word is derived from the Greek
— a, privative, and <f>aa-i,<;, speech — and, as stated by Trous-
seau, was proposed by M. Chrysaphis, a distinguished Greek
scholar, as a substitute for alalia, used by Lordat, and aphe-
mia, employed by Broca, to designate the same condition.

In the definition which I have given of aphasia, the term
is limited to impairment of the idea of language or of its
expression. It does not, therefore, include those cases in
which the individuals are able to speak, but will not ; such as
are met with among the insane. The idea of language is as
perfect as ever, and is doubtless entertained, but the person
does not speak because he does not will to do so, and this fail-
ure may arise either from a lack of the necessary power, or
from a stubborn determination not to speak. A lady was a
short time since under my charge who had been treated by a
homcBopathic physician as a case of aphasia. A very slight
examination was sufficient to convince me that the case was
one of hysteria. She had not spoken for several months, but

APHASIA.

167

upon one occasion she came to my office with her maid,
whom she required to repeat the alphabet, and when the
right letter was reached she signified the fact by raising her
hand. She thus spelled out the words she wished to use.
Subsequently she procured a card with all the letters on it,
such as are used for children learning their alphabet, and
she composed her words from this. Of course all these facts
showed that her idea of language was intact, but she still
might have lost the power of coordinating the muscles con-
cerned in articulation so as to express herself in spoken
words. Although I was sure this was not the case, I failed
to make her speak, until one morning, she became very much
interested in something I was saying, and, finding her alpha-
bet too slow a means of expression, dropped it and began to
speak with great fluency. After talking with energy for a
quarter of an hour, she suddenly recollected herself and took
up her card of letters again, but the charm was broken, and
by degrees she resumed her speech. At one time this lady
was under the care of my friend Prof. Flint, for some
chest or throat difficulty, and on one occasion spoke very
well.

N^either does aphasia embrace cases of inability to speak
from paralysis of the tongue or other muscles of articu-
lation. Defective speech from this cause is frequently met
with in hemiplegia, in glosso-laryngeal paralysis, and some
other affections. In such instances the idea of language re-
mains, but the patient does not speak because he is unable
to put the organs of articulation in motion. A few days
ago a gentleman, a prominent merchant of the city, was
sent to me as a case of aphasia. As he entered my consult-
ing-room, I saw that he was hemiplegic on the left side, and,
on telling him to put out his tongue, found that he could
not get it beyond the teeth, or touch the roof of his mouth
with it. The history of the case was that of ordinary cere-
bral haemorrhage, and he regained the power of speaking
after several applications of the primary and induced gal-

168

DISEASES OF THE BRAIN.

vailic currents had been made to the tongue and muscles of
the face.

The distinction between aphonia and aphasia must also
be made. In the one the idea of speech is undisturbed, and
articulation is not interfered with except as regards phona-
tion. Aphonic patients can whisper, but are unable to
speak in full voice, owing to some laryngeal affection im-
pairing the tone of the vocal cords.

The fact that the faculty of speech may be deranged in-
dependently either of the will, paralysis, or loss of voice,
appears to have been noticed at a very early period in the
progress of science. Thus Isaiah * says, " For with stam-
mering lips and another tongue will he speak to this peo-
ple;" and again," " Thou shall not see a fierce people, a peo-
ple of a deeper speech than thou canst perceive ; of a stam-
mering tongue that thou canst not understand,"

Thucydides mentions that many, who suffered from the
plague which raged at Athens, found on recovering that
they had not only forgotten the names of their friends and
relations, but also their own names.

Pliny,^ in the chapter entitled Memorice Exempla, says,
in speaking of this faculty : " For nothing is so weak in man ;
disease, falls, injuries, even a fright, may impair it partially,
or destroy it altogether. A blow from a stone has abolished
the memory of the alphabet. A fall from a high roof has
caused a man to cease to recognize his mother and neigh-
bors, another even forgot his slaves, and Messala Corvinus,
the orator, could not recall his own name." *

Suetonius ' relates that Claudius so far lost his memory
that he forgot the names of persons to whom he desired to
speak, and could not even recollect the words he wished to
use.

1 Chapter xxviii. 11. « Chapter xxxiii. 19. » ljij yj;^ p^p. xxiv.

* Trousseau has translated this passage somewhat differently. I quote from
an illuminated copy printed at Tarvisium (Treviso), in October, 1479.
^ C. Suetonii Tranquilli, xii., Caesares.

APHASIA.

169

Passing over several authors of later times who have rec-
ognized the existence of the difficulty in question, we come
to Crichton/ who remarks as follows : " There is a very sin-
gular defect of memory, of which I have myself seen two
remarkable instances. It ought rather to be considered as
a defect of that principle by which ideas and their proper
expressions are associated, than of memory, for it consists in
this, tliat the person, although he has a distinct notion of
what he means to say, cannot pronounce the words which
ought to characterize his thoughts. The first case of this
kind which occurred to me in practice was that of an attor-
ney much respected for his integrity and talents, but who
had many sad failings to wliich our physical nature too
often subjects us. Althougli nearly in his seventieth year,
and married to an amiable lady much younger than himself,
he kept a mistress, whom he was in the habit of visiting
every evening. The arms of Yenus are not wielded with
impunity at the age of seventy. He was suddenly seized
with great prostration of strength, giddiness, forgetfulness,
insensibility to all concerns of life, and every symptom of
approaching fatuity. His forgetfulness was of the kind al-
luded to. "When he wished to ask for any thing, he constantly
made use of some inappropriate term. Instead of asking
for a piece of bread, he would probably ask for his boots ; but,
if these were brought, he knew they did not correspond with
the idea he had of the thing he wished to have, and was there-
fore angry. Yet he would still demand some of his boots
and shoes, meaning bread. If he wanted a tumbler to drink
out of, it was a thousand to one he did not call for a certain
chamber utensil, and, if it was the said utensil he wanted, he
would call it a tumbler or a dish. He evidently was con-
scious that he pronounced wrong words, for, when the proper

' An Inquiry into the Nature and Origin of Mental Derangement, compre-
hending a Concise System of the Physiology and Pathology of the Human
Mind, and a History of the Passions and their Eflfects. London, 1798, vol. i.,
p. 371.

170

DISEASES OF THE BRAIN.

expressions were spoken by another person, and he was asked
if it were not such a thing he wanted, he always seemed
aware of his mistake, and corrected himself by adopting the
appropriate expression. This gentleman was cured of the
complaint by large doses of valerian and other proper medi-
cines."

Dr. Crichton subsequently met with another case simi-
lar to the foregoing, and he quotes the following from Prof.
Gruner, of Jena, in vol. vii. of the Psychological Magazine.
The patient, a learned gentleman, after his recovery from an
acute fever, suffered a loss of memory for words. Among
the first things he desired to have was coffee (Jcaffei), but, in-
stead of pronouncing the letter f, he substituted in its place
as, and therefore asked for a cat (hazze). In every word
which had an f he committed a similar mistake, substitut-
ing a z for it.

He also cites, from Yan Goens, the case of Madame Hen-
nert, wife of the professor of mathematics at Utrecht, who
suffered a similar defect of memory. When she wished to
ask for a chair she asked for a table, and when she wanted
a book she demanded a glass. But, what was singular in
her case was, that when the proper expression of her
thought was mentioned to her, she could not pronounce
it.

She was angry if people brought her the thing she had
named instead of the thing she desired. Sometimes she
herself discovered that she had given a wrong name to her
thoughts. This complaint continued several months, after
which she gradually recovered the right use of her recollec-
tion. It was only in this particular point that her memory
seemed to be defective, for M. Yan Goens assures us that
she conducted her household affairs with as much regularity
as she ever had done, and that she used to show her husband
the situation of the heavens on a map with as much accu-
racy as when she was in perfect health.

The following case, in Gesner's EndecTcungen der Neue8'

APHASIA.

171

ten Zeit in der Arzneigelehrheit, is likewise quoted by
Crichton :

" A man, aged seventy, was seized, about the beginning
of January, with a kind of cramp in the muscles of the
mouth, accompanied with a sense of tickling all over the
surface of the body, as if ants were creeping over it. On
the 20th of the same month, after having experienced an
attack of giddiness and confusion of ideas, a remarkable
alteration of his speech was observed to have taken place.
He articulated easily and fluently, but made use of strange
words, which nobody understood. The number of these
does not at present seem to be great, but they are frequently
repeated. Some of them he seems to forget entirely, and
then new ones are formed. When he speaks quick he some-
times pronounces numbers, and now and then he employs
common words in their proper sense. Tie is conscious that
he speaks nonsense. What he writes is equally faulty with
what' he speaks. He cannot write his name. The words
he writes are those he speaks, and they are always written
conformably to his manner of pronouncing them. He can-
not read, and yet many external objects seem to awaken in
him the idea of their presence."

Dr. Rush,' in the work the title of which is cited below,
in chapter xii,, which treats of Derangement in the Mem-
ory, refers so specifically to affections of the speech that I
quote his language with some degree of fulness, and I do so
with the less hesitation as his observations appear to have es-
caped notice, both in this country and in Europe. He says :

" 1. There is an oblivion of names and vocables of all
kinds.

" 2. There is an oblivion of names and vocables, and a
substitution of a word no ways related to them. Thus, I
knew a gentleman afflicted with this disease, who, in calling
for a knife, asked for a bushel of wheat.

1 Medical Inquiries and Observations upon Diseases of the Mind. Fourth
edition. Philadelphia, 1830, p. 274. The first edition was published in 1812.

172

DISEASES OF THE BRAIN.

" 3. There is an oblivion of the names of substances in a
vernacular language, and a facility of calling them by their
proper names in a dead or foreign language. Of this,
"Wepfer relates three instances. They were all Germans,
and yet they called the objects around them only by Latin
names. Dr. Johnson, when dying, forgot the words of the
Lord's prayer in English, but attempted to repeat them in
Latin. Delirious persons, from this disease of the memory,
often addresstheir physicians in Latin or in a foreign tongue,

" 4. There is an oblivion of all foreign and acquired lan-
guages, and a recollection only of vernacular language. Dr.
Scandella, an ingenious Italian, who visited this country a
few years ago, was master of the Italian, French, and Eng-
lish languages. In the beginning of the yellow fever which
terminated his life in the city of 'New York in the autumn
of 1798, lie spoke English only ; in the middle of his disease
he spoke French only ; but on the day of his death he spoke
only in the language of his native country.

" 5. There is an oblivion of the sound of words, but not
of the letters which compose them. I have heard of a cler-
gyman in Newburyport, who, in conversing with his neigh-
bors, made it a practice to spell every word that he employed
to convey his ideas to them.

6. There is an oblivion of the mode of spelling the
most familiar words. I once met with it as a premonitory
symptom of palsy. It occurs in old people, and extends to
an inability, in some instances, to remember any more of
their names than their initial letters. I once saw a will
subscribed in this way by a man in the eightieth year of
his age, who during his life always wrote a neat and legible
hand.

" 9. There is an oblivion of names and ideas, but not of
numbers. We had a citizen of Philadelphia many years
ago, who, in consequence of a slight paralytic disease, forgot
the names of all his friends, but could designate them cor-

APHASIA.

173

rectly by mentioning tlieir ages, with whicli he had pre-
viously made himself acquainted."

Dr. Rush remarks of these cases, that " there appears to
be something like a palsy of the mind, quoad these specific
objects."

Thus far there had been no attempt to define with pre-
cision the seat of the faculty of language, or even to estab-
lish its existence ; but, in the early part of the nineteenth
century. Dr. Gall, a German physician, announced that such
a faculty did exist, and that it was seated in those convolu-
tions of the brain which rest upon the posterior part of the
supra-orbital plate, and that a large development of the or-
gan was indicated by prominence and depression of the eyes.
He was first led to believe in the existence of such an organ
by observing that some of the scholars with whom, as a
young man, he had to compete, excelled him in the ability
to learn by heart, and he noticed that those thus endowed
with great memory for words possessed prominent eyes.
From these circumstances, he was gradually carried on to
the foundation of his phrenological system.

In reality, however. Gall considered that there were two
organs of language in each hemisphere — the one originat-
ing the idea of words, the other the talent for philology, and
for acquiring the spirit of languages. The former organ he
describes as lying on the posterior half of the supra-orbital
plate, as before mentioned. It gives a talent for learning
and recollecting words, and persons possessing it large re-
cite long passages by heart after reading them once or
twice. The other is placed on the middle of the supra-orbi-
tal plate, and when it is large the eyeball is not only ren-
dered prominent but is depressed, causing the lower eyelid
to assume the appearance of a bag or fold. Persons having
this organ large have not only an excellent memory for
words, but a particular talent for the study of languages, for
criticism, and in general terms for all that has reference to
literature. •

DISEASES OF THE BRAIN.

Dr. Spurzheim, however, admits but one organ, lying
transversely on the posterior portion of the supra-orbital
plate, and this view is accepted by Combe and other dis-
tinguished phrenological authorities.'

In support of his theory that there is such an organ,
Gall cites the case of a notary reported by Pinel." The
latter, in speaking of apoplexy, says this affection may be
limited in its action to the words which are used to express
ideas. In the case mentioned, the patient forgot, after an
attack of apoplexy, his own name, that of his wife, those of
his children and friends, although there was not the least
paralysis of his tongue. He no longer knew how to read or
write, and yet his memory as regarded other things was un-
impaired.

Dr. Gall ^ refers also to the case of a soldier, sent to him
by Baron Larrey, who was affected in a manner similar to
that of the notary. It was not his tongue which was in-
volved, for he was able to move it about in all directions,
and to pronounce words, but he had lost the memory for
words, although he recollected other things as well as ever.

I shall presently have occasion to refer to a still more
interesting case, reported by Larrey, and one which appears
to have escaped the notice of all writers on the subject of
aphasia.

Spurzheim mentions the case of one Lereard, of Mar-
seilles, who, having received a blow from a foil on the eye-
brow (which one is not stated), lost the memory of proper
names entirely. He sometimes even forgot the names of his
intimate friends, and even of his father.

Gall, therefore, located the organ of language in a limited

1 For a full account of the subject, the reader is referred to a System of
Phrenology, by George Combe, Boston, 1834, or to Phrenology, etc., by J. S.
Spurzheim, Boston, 1833.

" Traito Medico-Philosophique, sur I'ali^nation mentale. Second edition.
Paris, 1809, p. 90.

• ' Physiologic du cerveau, vol. iv., p. 84.

APHASIA.

175

part of the anterior lobe of eacli hemisphere ; but he ad-
duced very little evidence to support his opinion, and hence
his views did not meet with any thing like general accept-
ance. A number of cases, however, reported by Lallemand,
Hostan, and others, support it, while several adduced by
the same authors are opposed to it.

In 1825 Bouillaud,^ who had collected a great number
of cases of affections of the brain, was surprised to find how
frequently the loss of speech coexisted with disease or injury
of the anterior lobes. He also confirmed, what others before
him had noticed, that the loss of the power of expressing
ideas in articulate language was often the only evidence of
a brain-affection.

He made one very important step in advance, and his
views on this particular point are adopted — and often with-
out credit — by the majority of the present writers on apha-
sia : he divided the faculty of speech into two distinct cate-
gories of phenomena :

1. The faculty of creating words as representatives of
our ideas, and of recollecting them — internal speech.

2. The power of coordinating the movements necessary
for the articulation of these words — external speech.

This classification forms the basis of the division of
aphasia into the two varieties, the amnesic and the ataxic.

The cases which Bouillaud adduced in support of his '
theory were many of them in patients who exhibited no
other symptoms than the loss of the power of articulate
language. They preserved their intelligence, comprehended
perfectly questions put to them, and knew the value of
words ; but, although there was no paralysis of either the
tongue or the lips, they were unable to utter a word. At
the post-mortem examination, the lesion was always found
in the anterior lobes. Sixty-four cases formed the basis of

^ Traite de I'encephalite, Paris, 1825 ; and also, Recherches cliniques, pro-
pres k demontrer que la perte de la parole correspond k la lesion des lobules
anterieurs du cerveau, Archives de Med., 1825.

176

DISEASES OF THE BRAIN.

his conclusions. A part were direct, and went to show that
lesion of the anterior lobes was accompanied bj derange-
ment in the faculty of speech ; the other part were indirect,
and established the fact that, when the anterior lobes were
not affected, the lesion being in some other region of the
brain, the faculty of speech remained intact.

Cruveilhier opposed Bouillaud's views, and, in a paper
read at the Athenee de Medecine in the same year, brought
forward seven cases of persons, some of whom had lost the
faculty of speech, but who, on post-mortem examination,
were found to have no disease of the anterior lobes ; and
others who had spoken, but in whom there were more or
less profound changes in these parts.

Subsequently Andral ^ reported the results of the analy-
sis of thirty-seven cases of lesion of one or both anterior
lobes. Of these, speech was abolished twenty-one times,
and preserved sixteen times. Lallemand ^ also opposed Bou-
illaud with several cases ; but the latter rejoined ' with a
fresh array of thirteen cases in support of his doctrine, and
with many arguments against the validity of those brought
against him. Longet* declares that Bouillaud appears to
have refuted many of the objections of his adversaries, and
to have demonstrated that some of their cases were badly
interpreted. At the same time, while admitting that it is
possible that different parts of the brain preside over differ-
ent voluntary movements, he affirms that there is nothing
positively established as regards the localization of the ac-
tive principles of these movements.

Subsequently, in other memoirs, Bouillaud brought for-
ward additional cases in support of his theory, making a

' Clinique Medicale, t. ii., p. 135.

2 Op. cit., lettres 6, 7, 8.

3 Exposition de nouveaux faits k I'appui de ropinion qui localise dans les
lobes anterieurs du cerveau le principe legislateur de la parole. Bulletin de
I'Academie de Medecine, 1839, torn, iv., p. 282.

* Traite de la Physiologic, t. ii., p. 438.

APHASIA.

177

total of one hundred and three, and ofPered a prize of five
hundred francs to any one who would adduce an instance
of profound lesion of the anterior lobes without troubles of
speech. Many years subsequently Yelpeau announced that
he should claim this prize, for that, in March, 1843, he had
related the case, and presented the brain, of a wig-maker
who had come under his care for prostatic disease. This
man was in full possession of his reasoning faculties, and,
moreover, was noted for his unconquerable loquacity. He
died a few days subsequently, and on post-mortem examina-
tion a scirrhous tumor was found to have entirely taken the
place of the two anterior lobes of the brain. Yery little
faith seems to have been put by physiologists or pathologists
in the history of this case. If it proves any thing, it is that
the anterior lobes are useless appendages to the rest of the
cerebral system.

But Bouillaud was not content with the deductions to
be drawn from pathology. In a series of experiments, he
endeavored to establish the truth of his idea, and thus bring
the science of physiology to his support. These experi-
ments were detailed in a paper ' read before the Academy
of Sciences, in September, 1827, which was subsequently
(1830) published in the tenth volume of Magendie's Journal
de Physiologie, from which I quote.

The experiments relative to the anterior lobes were made
on dogs. Only one was entirely successful — the animals in
the others dying too soon after to admit of satisfactory de-
ductions being made. But the twentieth experiment was
more satisfactory.

On tlie 28th of June, 1826, he passed a gimlet through
the anterior part of the brain of an active, docile, and intel-
ligent dog. Immediately afterward the animal was con-
vulsed, and could not rise from the ground. Sight and
hearing remained. Symptoms of compression soon came on ;

' Recherches experimentales sur les fonctions du cerveau (lobes cerebraux) en
g^n^ral et sur celles de sa portion anterieure en particulier.

178

DISEASES OF THE BRAIN,

the result, probably, of the lisemorrliage. Eventually, the
animal recovered, but it was found to have lost much of its
intelligence and agility. The faculty of memory seemed to
have been entirely abolished, and there was a decided expres-
sion of imbecility in its countenance. It could no longer
ascend or descend a staircase ; the fore-legs were lifted very
high in walking, and its movements were all badly coordi-
nated. When struck or made to walk, it uttered sharp
cries, but it had lost entirely the ability to bark. As Bou-
illaud remarks, " it no longer barked, either to show its
aflfection, or to drive away strangers who came to the house."
Once only, on the 18th of July, it tried to bark at a passer-
by, but failed in the attempt.

This is the only experiment I have been able to find
which has any bearing upon the question of the localization
of the faculty of language. And I do not quote it as prov-
ing much on the subject. The difficulties in the way of
experimentation are almost insuperable, to say nothing of
the fact that it is doubtful if any of the sounds made by
animals can be compared with human speech.

But unintentional experiments have been performed
upon the human subject, which tend to show that, though
the faculty of language may be located in one or both an-
terior lobes, either may be seriously injured without the
faculty of language suffering to any appreciable extent.
Two of them have happened in this country, and, although
referred to in connection with aphasia by Seguin and Har-
ris, I take great satisfaction in bringing them forward on
account of their great importance to the question under
consideration.

The first is related by Dr. Harlow,^ of Vermont :

The subject was a strong, healthy man, twenty-five years
of age, and was engaged in ramming down a charge of

■ Boston Medical and Surgical Journal, December, 1849, vol. xxxix., p. 389.
Also Descriptive Catalogue of the Warren Anatomical Museum. Boston, ISYO,
p. 145.

APHASU.

1Y9

powder in a rock to be blasted, when an explosion took
place, and the tamping-iron was driven clear through his
head.

In a few minutes he recovered his consciousness, was
put into a cart and carried three-quarters of a mile to his
residence, where he got out and walked into the house.
Two hours afterward he was seen by Dr. Harlow. He was
then quite conscious and collected in his mind, but ex-
hausted by extensive haemorrhage from the hole in the top
of his head. Blood, pus, and particles of brain, continued to
be discharged for several days, but by January 1, 1849, the
wound was quite closed and his recovery complete. There
was no pain in the head, but a queer feeling, which he could
not describe. As regarded his mind, he was fitful and va-
cillating, though obstinate, as he had always been. He be-
came very profane, never having been so before the accident.
He lived till May 21, 1861, twelve and a half years subse-
quent to the accident, when he died, after having had several
convulsions. His cranium was obtained, and, with the bar,
is now presei*ved in the "Warren Anatomical Museum at
Boston. Dr. J. B. S. Jackson * thus describes the skull :

" The whole of the small wing of the sphenoid bone
upon the left side is gone, with a large portion of the large
wing, and a large portion of the orbital process of the frontal
bone, leaving an opening in the base of the skull two inches
in length, one inch in width posteriorly, and tapering gradu-
ally, and irregularly to a point anteriorly. This opening
extends from the sphenoidal fissure to the situation of the
frontal sinus, and its centre is an inch from the median line.
The optic foramen and the foramen rotundum are intact.
Below the base of the skull the whole posterior portion of
the uj^per maxillary bone is gone. The malar bone is un-
injured ; but it has been very perceptibly forced outward,
and the external surface inclines somewhat outward from
above downward. The lower jaw is also uninjured. The

' Descriptiyc Catalogue of Warren Anatomical Museum, loc. cit.

180

DISEASES OF THE BRAIN.

opening in the base, above described, is continuous with a
line of old and united fracture that extends through the
supra-orbitary ridge in the situation of the foramen, inclines
toward and then from the median line, and terminates in
an extensive fracture that was caused by the bar as it came
out through the top of the head. This fracture is situated
in the left half of the frontal bone, but interiorly it extends
somewhat over the median line. In form it is about quadri-
lateral ; but it measures two and a half by one and three-quar-
ter inches. Two large pieces of bone are seen to have been
detached and upraised, the upper one having been separated
at the coronal suture from the parietal bone, and being so
closely united that the fracture does not show upon the
outer surface. The lower piece shows the line of fracture
all around. Owing to the loss of bone, two openings are
left in the skull ; one that separates the two fragments has
nearly a triangular form, extends rather across the median
line, and is four inches in circumference ; the other, situated
between the lower fragment and the left half of the frontal
bone, is long and irregularly narrow, and is two and five-
eighths inches in circumference. The edges of the fractured
bones are smooth, and there is nowhere any new deposit."

From this account it will be seen that the left anterior
lobe of the brain suffered severely by this terrible injury, and
yet it is not stated that the subject had ever shown any dif-
ficulties of speech. If the faculty of language resides in the
whole of the lobe, such an immunity could scarcely have
existed. It must be noted, however, and the photograph
of the cranium establishes the fact, that the third frontal
convolution and the island of Reil escaped all injury. An-
other interesting circumstance is the addiction to profanity
after the accident. A like phenomenon has been noticed in
cases of aphasia.

The second instance is almost as extraordinary. I quote
the history of the case, 952, from Dr. Jackson : '

* Op. cit., p. 149

APHASIA.

181

" Cast of the liead of a man who was transfixed through
the head by an iron gas-pipe, and who, to a very considerable
extent, recovered from the accident.

" The patient, a healthy and intelligent man, about twen-
ty-seven years of age, was blasting coal when the charge
exploded unexpectedly, and the pipe was driven through
his head, entering at the junction of the middle and outer
thirds of the right supra-orbitary ridge, and emerging near
the junction of the left parietal, occipital, and temporal bones.
One of his fellow-miners saw him upon his hands and knees,
and struggling as if to rise; and, going to his assistance, he
placed his knee upon his chest, supported his head with one
hand and with the other withdrew the pipe. This last pro-
jected about equally from the front and back of the head,
and much force was required for its withdrawal."

Brain escaped from the anterior opening, and coma and
collapse supervened. " In seven weeks he sat up, and in
one more walked about. The right hand he used somewhat,
but less well than the left. For about ten months after the
accident his memory for some things was nearly lost, but
during the next two months there was a considerable im-
provement."

The accident happened on May 14, 1867, and in June,
1868, the patient, with the gas-pipe, was exhibited to the
Massachusetts Medical Society. " The man appeared to be
in a good state of general health ; and, though his mental
powers were considerably impaired, there was nothing un-
usual in his expression, nor would there be noticed, in a few
minutes' conversation with him, any marked deficiency of
intellect."

It is very evident that in this case the right anterior lobe
was seriously injured — the left escaping — and yet there
does not appear to have been any aberration of speech. It
is to be regretted, however, that the history is not more
specific as to the things in regard to which the memory was
deficient.

182

DISEASES OF THE BRAIN.

There are other cases which militate against Bouillaiid's
doctrine. Thus, M. Peter * states tliat a drunken cavalrj-
soldier fell from his horse on the back of his head, and frac-
tured his skull. Stupor set in at once, followed by the most
violent delirium. The man kept constantly shouting the
worst possible oaths, and held connected conversations with
imaginary persons. He died at the end of thirty -six hours,
without having recovered his reason. On dissection, a frac-
ture of the roof and base of the skull was found in all its
length. The posterior lobes of the brain were found, on
post-mortem examination, to have sustained no injury, but
both anterior lobes were in a pulpy condition, through a
most violent contusion, caused by their being knocked
against the anterior wall of the cranium. The whole thick-
ness of the lobes was disorganized. As Trousseau remarks,
this case shows that the two frontal lobes may be destroyed
in their anterior portion without causing a loss of the faculty
of speech. Trousseau also cites the case of two officers,
who, after a quarrel, fought a duel. One of them fired first,
and the ball entered his adversary's head at one temple,
passed through the brain, and then raised the temporal bone
on the opposite side. The ball was extracted, and the pa-
tient immediately made a sign with his hands, and expressed
his thanks in a very low voice. He recovered, for the time
being, and, during five months thereafter, could speak per-
fectly well, and was remarkable for the wit and fluency of
his conversation and writing. He subsequently died of
softening; and it was found, on post-mortem examination,
that the ball had passed through the two frontal lobes in
their middle portion. A still more striking case is referred
to by Dr. Bazire, in a note to Trousseau's lecture on apha-
sia, in the work cited. It was reported in 1843 by M.
Aug. Berard, to the Anatomical Society of Paris. The pa-
tient, a miner, was knocked down and severely injured by

' Quoted by Trousseau, Lectures on Clinical Medicine. Translated by Ba-
zire, vol. i., p. 256.

APHASIA.

183

an explosion in a mine. He did not lose consciousness, but
managed to creep out of Lis liole and to call to his help some
men who were working a short distance otF. He begged
them to fetch a cart and to take him to M. Berard's house.
He was there examined. The whole frontal region was laid
open, the integuments hung in shreds, the bones were splin-
tered and in detached fragments, and the brain was exposed.
Both anterior cerebral lobes were completely destroyed, and
in their stead was a mixture of blood, of bony splinters, and
brain-substance. In spite of this frightful injury the man
could relate in all its details how the accident had occurred.
He died the next day.

Whether or not we accept this case in all the import
claimed for it, there can be no doubt that Bouillaud is wrong
in claiming that injury of the anterior lobes is necessarily
followed by some derangement in the faculty of speech. It
is only fair, however, to state that latterly he has admitted
that the organ of language may occupy the posterior part
of either lobe.

Dr. M. Dax, in 1836, read a paper before the medical
congress which met that year at Montpellier, in which he
came to the conclusion that the faculty of language " was
seated, not as Gall and Bouillaud had contended, in both
anterior lobes of the brain, but that it occupied only the left
anterior lobe." He based this opinion on one hundred and
forty cases of aphasia attended with paralysis, and in which
the loss of power was on the right side ; showing, therefore,
that the lesion which produced the aberration of speech also
caused the hemiplegia, and that this lesion must have been
on the left side. This paper at the time attracted very little
attention, and was forgotten till the year 1861 witnessed
the reopening of the discussion.*

It would be very easy to quote a large number of cases
confirmatory of Dr. Dax's doctrine, but a few will suffice to

' Dr. Marc Dax's Memoir was republished in the Gazette Hebdomadaire, No.
17, April, 1865.

184

DISEASES OF THE BRAIN.

show the general bearing of a great many others. The fol-
lowing case seems to have escaped notice. It is not the one
referred to by Gall as being sent to him by Larrey. In that
case the left anterior lobe was injured and there was aphasia,
but the lesion was caused by a sword.

Baron Larrey ' presented to the Academy the cranium
of a subject, with the following history :

Toward the end of the year 1815 an officer of dragoons
came to the hospital with a wound from a ball which he had
received at Waterloo. The missile had entered the left side
of the cranium at a point about six or eight millimetres
from the eyebrow and near the temporal ridge. At first he
had suffered loss of consciousness and profuse haemorrhage,
but had recovered, with but slight loss of motor power. So
far as his mind was concerned, there was no derangement
except as regarded the faculty of speech ; he had lost the
memory of substantives. For this reason he was unable to
drill his company, and, though able to distinguish his men
by their size, their form, their complexion, or their voice, he
could not call them by name. He refused to allow the
operation of trephining to be performed, and in 1827 died
of phthisis.

A post-mortem examination was made. The ball was
found embedded in the thickness of the bone, having ele-
vated and fractured the internal table. The dura mater
was strongly adherent to the whole of the left anterior cra-
nial fossa ; it was also thicker and denser than in the natural
state. A spheroidal excavation, five centimetres in its hori-
zontal and seven or eight in its vertical diameter, was dis-
covered at the summit and on the temporal side of the left
anterior lobe of the brain.

Mr. Thomas Hood ' reported the history of a patient, a

1 Blessure du Cerveau avec perte de Memoire des Noms Substantives. Jour-
nal de Physiologie de Majendie, t. viii., 1828, p. 1.

2 Phrenological Transactions. Quoted by George Combe in his System of
Phrenology, Boston, 1834, p. 429.

APHASIA.

185

sober, intelligent man, sixty years of age, who, on the even-
ing of September 2, 1822, suddenly began to speak incohe-
rently, and became quite unintelligible to those around him.
It was discovered that he had forgotten the name of every
object in Nature. His recollection of things seemed to be un-
impaired, but the names by which men and things were
known were entirely obliterated from his mind, or rather he
had lost the faculty by which they were called up at the con-
trol of the will. He was by no means inattentive, however,
to what was going on, and he recognized friends and ac-
quaintances perhaps as quickly as on any former occasion ;
but their names, or even his own or his wife's name, or the
names of any of his domestics, appeared to have no place in
his recollection.

" On the morning of the 4th of September," says Mr.
Hood, " much against the wishes of his family, he put on
his clothes and went out to the workshop, and when I made
my visit he gave me to understand, by a variety of signs,
that he was perfectly well in every respect, with the excep-
tion of some slight sensations referable to the eyes and eye-
brows. I prevailed on him with some difficulty to submit
to the reapplication of leeches, and to allow a blister to be
placed over the left temple. He was now so well in bodil}^
health that he would not be confined to the house, and his
judgment, in so far as I could form an estimate of it, was
unimpaired, but his memory of words was so much a blank,
that the monosyllables of affirmation and negation seemed to
be the only two words in the language the use and signifi-
cation of which he never entirely forgot. He comprehended
distinctly every word which was spoken or addressed to him ;
and, though he had ideas adequate to form a full reply, the
words by which these ideas are expressed seemed to have
been entirely obliterated from his mind. By way of experi-
ment I would sometimes mention to him the name of a
person or thing, his own name for example, or the name
of some one of his domestics, when he would repeat it

186

DISEASES OF THE BRAIN.

after me distinctly once or twice ; but generally before be
could do so a tbird time tbe word was gone from bim as
completely as if be bad never beard it pronounced. Wben
any person read to bim from a book, be bad no difficulty in
perceiving tbe meaning of tbe passage, but be could not
bimself tben read, and tbe reason seemed to be tliat be bad
forgotten tbe elements of written language, viz., tbe names
of tbe letters of tbe alpbabet. In tbe course of a sbort time
be became very expert in tbe use of signs, and bis convales-
cence was marked by bis imperceptibly acquiring some gen-
eral terms wbicli were witb bim, at first, of very extensive
and varied application. In tbe progress of bis recovery,
time and space came botb under tbe general application of
time. All future events and objects before bim were, as be
expressed it, ' next time ; ' but past events and objects be-
bind bim were designated ' last time.'' One day, being
asked bis age, be made me to understand tbat be could not
tell ; but, pointing to bis wife, uttered tbe words, ' many
times,'' repeatedly, as mucb as to say tbat be bad often told
ber bis age. Wben sbe answered sixty, be answered in tbe
affirmative."

On tbe lOtli of January be suddenly became paralytic
on tbe left side [tbis is evidently a typograpbical error for
rigbt side]. On tbe lYtb of August be bad an attack of
apoplexy, and on tbe 21st be expired. In tbe Phrenologi-
cal Journal, vol. iii., p. 28, Mr. Hood bas reported tbe dis-
section of bis brain : "In tbe left bemispbere, lesion of tbe
parts was found, wbicb terminated at balf an incb from tbe
surface of tbe brain, wbere it rests on tbe middle of tbe su-
pra-orbital plate." Two small depressions or cysts were
found in tbe substance of tbe brain, " and tbe cavity consid-
ered as a wbole expanded from tbe anterior part of tbe brain
till it opened into tbe ventricle in tbe form of a trumpet.
Tbe rigbt bemispbere did not present any remarkable ap-
pearance."

APHASIA.

187

Dr. Thomas Ilun', of Albany, in detailing a
case of amnesia in which there were no symptoms of paral-
ysis, and in which there was no post-mortem examination,
cites the case of a lady who died of cancer of the brain, oc-
cupying, at the time of her death, the greater portion of the
left anterior lobe. In the early stages of her disease she
was often unable to call the most familiar objects by name,
and had to express herself by signs or by pointing at the ob-.
ject. "When the word she wanted was pronounced before
her, she recognized it, and was able to repeat it.

Other cases, and especially several which have occurred
in my own experience, are reserved for future consideration.

Up to this period we have the organ of articulate lan-
guage limited to the left anterior lobe of the brain, but in
1861 its location was still further restricted. In that year
M. Gratiolet, in discussing before the Anthropological So-
ciety of Paris a question relative to the comparative devel-
opment of the brain and mind among different races, brought
up the subject of cerebral localization, to which he announced
himself as being strongly opposed. M. Auburtin, on the
contrary, contended that the localization of the faculty of
speech at least was definitely established, through the re-
searches of Bouillaud, in the anterior lobes. In support of
this view, he adduced cases which had already been brought
forward, and cited others in addition, which went to show
that loss of speech was the consequence of traumatic lesion
of these parts of the brain. His adversaries cited other cases
in which persons had preserved the faculty of language not-
withstanding extensive lesions of the anterior lobes. M.
Auburtin responded that, if such profound and extensive in-
juries had not interfered with speech, it was because that
part of the lobes in which the organ is situated was not in-
volved. And he then cited the case of a patient in the Hos-
pital for Incurables, who for many years had been deprived
of the power of speech, and he declared that he would re-

' American Journal of Insanity, vol. vii., 1850-51, p. 359.

188

DISEASES OF THE BRAIN.

nounce the doctrine of Bouillaud if the autopsy of this patient
did not reveal disease of the anterior lobes. The patient in
question was under the charge of M. Broca, and the latter, a
decided opponent, accepted the challenge of M. Auburtin,
and declared that, when the man died, the examination
should be made.

Some time afterward the patient died, the post-mortem
examination was made, and the lesion was found to occupy
the left anterior lobe.'

From this time forward, M, Broca, who had been a most
determined opponent of Bouillaud's views of localization,
became converted, and carried them to a still more extreme
point than even M. Marc Dax had done. Taking, as his
principal case, the one to which M. Auburtin had pinned his
faith, he read, in 1861, before the Anatomical Society of
Paris, a memoir," in which he discusses the question of the
location of the faculty in question with all his perspicuity
and directness. As the two cases cited by him are of his-
torical interest, I give the chief details of them :

A man named Le Borgne, who had been an inmate of
another department of Bicetre for over twenty years, was
transferred to one of the wards under M. Broca's care, to
be treated for a severe attack of phlegmonous erysipelas.
The man was a confirmed epileptic, and had not spoken,
since his entrance into the hospital, more than a few words,
which he employed for the expression of all his ideas. It
is stated that in other respects his intelligence was good.
Le Borgne was known in the hospital by the name of '* Tan,"
a word which he habitually used, and which, with the oath,
" Sacre nom de Dieu^'' constituted his entire vocabulary.
"Tan," owing to the constancy with which he used it, was
the name by which he was known in the hospital ; and, when

' See Etude sur la localisation de la Faculte du Langage jirticule. These
de Paris de M. Carrier, 1867.

' Sur le siege de la faculte de langage articul6 avec deux observations
d'aphemie. Bull, de la Soc. Anatomique, t. iv., 1861.

APHASIA.

189

he could not make himself understood by his signs, he em-
ployed the oath, and gave other manifestations of anger.

Yov several years he had remained in the hospital with
no other lesion than that of speech, with an occasional
epileptic paroxysm ; but, after a few years, his right arm
became paralyzed, and four years subsequently the leg of
the same side was involved ; his sight was likewise enfee-
bled, and for the past seven years he had been entirely con-
fined to his bed.

Notwithstanding the fact that he was almost in a dying
condition when M. Broca first saw him, some important
points in his cerebral difiiculty were noted. To any ques-
tion put to him, he replied, as usual, " Tan,^^ but at the same
time endeavored to make himself understood by signs.
Thus he raised six fingers to indicate that six days had
elapsed since the inception of his erysipelas, and by opening
and shutting his hand four times and then raising one finger
signified that he had been twenty-one years in Bicetre.

Sensibility was lessened on the affected side ; there was
no deviation of the tongae, which could be moved freely in
all directions, and no paralysis of the face beyond a slight
weakness shown by the swelling of the left side when he
breathed ; there was a little difiiculty of swallowing, from
the fact that the muscles of the pharynx were gradually be-
coming implicated.

After a few days the man died.

As I have said, the autopsy showed that the lesion was
situated in the left anterior lobe. More exactly, however,
it should now be stated that it involved the inferior margi-
nal convolution of the temporo-sphenoidal lobe, the convo-
lutions of the island of Reil, and in the frontal lobe, the
frontal transverse convolution, and the posterior half of the
second and third frontal convolutions. The left corpus stria-
tum was also affected. According to Broca, the disease had
in all probability begun in the third frontal convolution,
and had gradually extended to the other parts ; the paraly-

190

DISEASES OF THE BRAIN.

sis marking the implication of tlie island of Eeil and the
corpus striatum.

The other case was that of a man named Le Long, aged
eighty-four years, who had entered the hospital for a frac-
ture of the neck of the femur. Eighteen months before, he
had been treated in the medical service for a temporary
apoplexy, which had deprived him of the faculty of speech,
but had caused no paralysis. Le Long, whose intelligence,
facial expression, and ability to gesticulate, were very strik-
ing, made himself perfectly well understood, although able
to pronounce indistinctly a very few words, but which were
nevertheless properly applied. These words were " owi^,"
" non, toujours, tois " for trois, and Zelo for Long. Thus,
when asked, " Can you write ? " he answered, " Oui."
" Have you any children ? " " Oui." " How many ? " Tois,"
but at the same time, as if aware that he was not answer-
ing correctly, he raised four fingers. " How many boys ? "
" Tois," raising two fingers. " How many girls ? " " Tois,"
holding up two fingers. " What time is it by this watch ? "
" Tois," at the same time raising ten fingers to signify that
it was ten o'clock. " How old are you ? " To this question
he replied by two gestures ; the one consisting of raising
eight fingers, the other of four fingers, by which he meant
that he was eighty-four years old.

Aside from this application of the word tois to all num-
bers, his answers were perfectly correct. The tongue was
neither paralyzed nor thickened ; on one side the larynx was
mobile, and his limbs possessed their normal power for his
age. It was therefore a case of pure aphasia, or, as Broca
then designated the affection, aphemia.

Twelve days after the accident, the patient died. The
post-mortem examination revealed the existence of lesions,
almost identical in situation with those of the former case.
The posterior part of the third left frontal convolution, and
the contiguous part of the second, had been absorbed and
replaced by a serous fluid. Two cases can scarcely decide

APHASIA.

191

any point in pathology ; but, without venturing to assert posi-
tively that the organ of language resides exclusively in the
posterior part of the third frontal convolution, M. Broca
expressed the opinion that the integrity of this convolution,
and perhaps of the second, is indispensable to the normal
operation of the function of speech.

Many cases were adduced by Charcot,' by Falret," by
Perroud ^ of Lyons, by Trousseau,* and others, in support of
the localization of the faculty of articulate language in the
left side of the brain. Most of tliese cases were accom-
panied by right hemiplegia, and, in several, post-mortem
examinations showed the lesion to exist in the parts desig-
nated by Broca.

In the early part of 1863, M. G. Dax, son of the M. Dax
who had placed the organ of language in the left hemi-
sphere, presented, through M. Lelut, a memoir to the Acad-
emy, in which he claimed with his father that aphasia was
always the result of lesion of the left hemisphere, but he as-
signed a still more restricted position, by limiting it to the
anterior and exterior part of the middle lobe. He cited
forty cases of loss of the power of speech, coincident with
lesion of the left hemisphere.

l^ow, besides these direct cases, there are others which
bear with almost as much effect on the affirmative of the
doctrine in question. Thus M. Fernet, in 1863, presented a
case to the Societe de Biologic, in which there was left
hemiplegia, but no aphasia. After death, softening of the
right hemisphere, from thrombosis of the right middle cere-
bral artery, was found to exist. M. Parrot ^ adduced another
case in which there was complete atrophy of the island of
Reil, and of the third convolution of the right side, but in
which there was no trouble of speech. These cases go to

' Gazette Ilebdom., 1863, pp. 473, 525.

* Archives de Med., t. iv.. Mars et Mai, 1864.

2 Journal de Med. de Lyon. Jan. et Fev., 1864.

* Cbnique Medicale. * Gazette Hebdom., 1863, p. 506.

192

DISEASES OF THE BRAIN.

show that the organ of articulate language is not situated in
the right hemisphere.

M. Lesur * has reported a case which is of very great
interest. A child was kicked on the head by a horse, and a
fracture of the frontal bone was thus produced. The opera-
tion of trephining was performed at a point about an inch
and a quarter above the left eye. After the operation and
during the progress of the case, it was observed that, when-
ever pressure was made upon the brain through the hole in
the cranium, the child lost the power of speech, and that
when this pressure was removed she regained it. A similar
case occured several years ago in my own practice.

Among British writers. Dr. Hughlings Jackson^ has
given the histories of thirty -four cases of loss of speech co-
inciding with right hemiplegia. He is entitled to the credit
of making a beautiful application of anatomy and physi-
ology to the pathology of the subject under consideration.
The part of the brain designated by Broca as the seat of
the organ of articulate language is nourished by the left
middle cerebral artery. An obstruction of this artery would
of course interfere with the perfect action of that region,
and thus aberrations of speech would be produced. But
the same artery also supplies blood to the corpus striatum
of the same side. Hence the frequency with which aphasia
is associated with right hemiplegia. The cause of the ob-
struction is generally, according to Dr. Jackson, embolism,
for in twenty of his cases the heart was more or less affect-
ed, and in thirteen of them there was valvular disease.

Among other British writers, some of whom will be more
fully referred to hereafter, must be mentioned, Dr. Sanders,'
Dr. Moxon,* Dr. Ogle,' Dr. Bateman," and Dr. Bastian.'

1 Gazette des Hopitaux. = London Hospital Reports, vol. I

' Edinburgh Medical Journal, August, 1866.

* British and Foreign Medico-Chirurgical Review, April, 1866.

^ St. George's Hospital Reports, vol. ii., 1867.

« Journal of Mental Science, January, 1868, and subsequent numbers.

' British and Foreign Medico-Chirurgical Review, January and April, 1869.

APHASIA.

193

The matter does not appear to have attracted much at-
tention from German physiologists and pathologists, since
the discussion in the French Academy in 1861. Previous
to that period several excellent memoirs upon the physi-
ology of speech were published by Germans, among which
that of Dr. Bergman ^ is preeminent. A memoir by Nasse *
is also interesting.

In 1865 Von Benedict, and Braunwart^ published a
very thorough paper on the subject, and other observers
have reported cases.

In this country there have been several very excellent
memoirs upon aphasia, and, as we have already seen, the
subject early attracted attention, and the fact that such a
condition could exist without other manifest symptoms was
fully recognized. Thus, Prof. A. Flint * detailed the histo-
ries of six cases, in one of which post-mortem examination
showed extensive disease of the left anterior lobe, and in
four, in which the situation of the hemiplegia was noted, the
right was the affected side.

Dr. H. B, Wilbur,^ in a memoir on aphasia, treats of
the aberrations of the faculty of language as they existed in
certain idiots under his observation. His cases, though in-
teresting, are scarcely in point, as the difficulties of speech
were clearly the result of mental deficiencies.

A very important memoir is that of Dr. E. C. Seguin,*
in which a very excellent history of the subject is given,
with the citation of forty-eight cases from the records of the
IS'ew York Hospital, in which there were difficulties of
speech coexisting with hemiplegia, and two in which there
was no hemiplegia. In several of these cases, however,

' Einige Bemerkungen iiber Storungen des Gedachtniss und der Sprache.
Allgemeine Zeitschrift fiir Psychiatrie, 1849, s. 65*7.
2 All. Zeitschrift, u. s. w., 1853, s. 523.
' Canstatt's Jahresbericht, 1865, s. 31.
* Medical Record (New York), March 1, 1866.
" American Journal of Insanity, July, 1867.

•Quarterly Journal op PsrcHOLOGiCAL Medicine, etc., January, 1868.
13

194

DISEASES OF THE BRAIN.

as Dr. Seguin states, the loss of the faculty of speech was
due to paralysis of the tongue and other muscles concerned
in articulation.

Another excellent paper is by Dr. T. "W. Fisher/ of Bos-
ton. Dr. Fisher has studied the subject very philosophi-
cally, and records thirty-eight cases in which post-mortem
examinations were made with definite results. Cases have
also been published by Bartholow " and others.

With this outline statement of the history of the subject
of aphasia, we are in a position to inquire more fully into
the evidence which locates the organ of language in a par-
ticular region of the brain.

A clear idea of the anatomy of the parts fixed upon lat-
terly as the seat of the faculty will aid in the understanding
of the subject.

The following account is condensed by Dr. Bateman'
from Broca's description in his essay " Sur le Siege de la
Faculte du Langage articule : "

" The anterior lobe of the brain comprises all that part
of the hemisphere situated above the fissure of Sylvius,
which separates it from the temporo-sphenoidal lobe and
in front of the furrow of Rolando which divides it from the
parietal lobe. The furrow of Rolando separates the frontal
from the parietal lobe ; it traverses from above downward
all the external surface of the cerebral hemisphere, starting
from the inter-hemispheric median fissure, and ending at
the fissure of Sylvius. In front, this furrow is bounded by
the transverse frontal convolution, and behind by the trans-
verse parietal convolution. The anterior lobe is composed
of two stories or divisions — one inferior or orbital, the other
superior — situated beneath the frontal and under the most
anterior part of the parietal. This superior division of the
anterior lobe is composed of four fundamental convolutions ;

J Boston Medical and Surgical Journal, September 1, 1870, and subsequent
numbers.

' Medical Eepertory, Cincinnati, January, 1869. ^ Op. cit., p. 522.

APHASIA.

195

one posterior, the others anterior. The posterior is that
which has been described as the transverse frontal, and
which forms the anterior border of the furrow of Eolando ;
the three other convolutions have all an antero-posterior
direction, and are distinguished by the names of superior
or first frontal, middle or second, and inferior or third
frontal convolutions. This last, by its posterior half, forms
the superior border of the fissure of Sylvius, the inferior
border being formed by the superior convolution of the
temporo-sphenoidal lobe. In drawing asunder these two
convolutions which bound the fissure of Sylvius, the lobe
of the insula (the island of Reil) is exposed, which covers

Fig. 6.

FROM BROCA, AS MODIFIED BT DR. HTTGHLINGS JACKSON.

1. First Frontal Convolution ; 2. Second Frontnl Convolution ; 3. Third Frontal Con-
volution ; O. Orbital Convolutions ; E F. Transverse Frontal Convolution ; P.
Parietal Lobe; T S. Temporo-sphenoidal Lobe; T 1. First Temporo-sphenoidal
Convolution; T 2. Second Temporo-sphenoidal Convolution; L Island of Eeil;
RR. Furrow of Rolando ; S. Fissure of Sylvius.

the extra ventricular nucleus of the corpus striatum. The
result of these relations is that a lesion, which is propagated
from the frontal to the temporo-sphenoidal lobe, or vice
versa, will pass almost necessarily by the lobe of the insula,
and thence, in all probability, it will extend to the extra

196

DISEASES OF THE BRAIN.

ventricular nucleus of the corpus striatum, seeing tliat the
proper substance of tlie insula, which separates the nucleus
from the surface of the brain, is composed only of a very
thin layer."

The lobe of the insula, or the island of Eeil, is found in
no other mammal than man and the monkey. In the latter,
however, it is very slightly developed, and has no trace of
convolutions. In aberrations of speech this part is very
often involved in the lesion.

Kow, although there are several cases on record in which
post-mortem examination would appear to show that lesion
of the third left frontal convolution is sufficient to produce
derangement of the faculty of articulate language, the
weight of evidence is decidedly against limiting the seat of
the organ to this part. Thus, of five hundred and fifty-six
cases of aphasia tabulated by Seguin,* the third frontal con-
volution was damaged but in nineteen. While, therefore,
we must admit that injury or disease of this limited region
will cause aphasia, it is going too far to assert that the
lesion must exist in this situation in order that aphasia may
be produced. Moreover, Seguin gives another table of cases
which must definitely settle the matter, and which I quote
in full. It relates to autopsies which were made with spe-
cial reference to the point in question, and in which the de-
tails given were sufficient clearly to indicate the location of
the lesion.

QUESTION OF THIED LEFT FRONTAL CONVOLUTION.

AUTHORITIES.

For.

Against.

Trousseau, 1865 (in Acad, de Med.)

Peter, Legrand, Beclard, Delpech, Bdrard, Farge,

Jackson, Bigelow

Jackson, Richardson, Russel. . . .,
New York Hospital, 1830-1867 .
Bellevue Hospital, October, 1867

3
1

7
1

Total

' Op. cit., p.

97.

APHASIA.

197

Other cases miglit readily be adduced, but the above are
amply sufficient to decide the question against Broca's doc-
trine. One case of aphasia occurring without lesion of the
third frontal convolution would of course invalidate his claim
that this part is the exclusive seat of the organ of language,
and no number of cases showing coexistence of aphasia with
disease or injury of the third left frontal convolution would
be sufficient to establish the point affirmatively with the re-
sults of our present experience disproved. Nevertheless, as
showing further that disease of this part will cause aphasia,
I subjoin the following case from Dr. W. Ogle's ' ver}"- in-
teresting memoir :

" Joel B., October 18, 1866. Had rheumatic fever and
endocarditis twenty-five years ago, but since that has had
good health. "While at work, October 15th, fell down sud-
denly without losing consciousness, and found that he was
speechless, and hemiplegic on the right side.

" On admission he was found to have extensive heart-
disease, with the pulse characteristics of aortic regurgitation.
There was complete lax palsy of the right arm and leg, with
unimpaired sensibility. There was at first some difficulty
in deglutition and in protruding the tongue, but this latter
symptom passed away in a few days. There was slight pain
in the left side of the head.

" His speech was limited to the two words ' yes ' and
'no.' These he used correctly. After he had been in the
hospital some time, he recovered the power of saying some
few words, chiefly monosyllables.

" He could wi'ite with his left hand, with sufficient dis-
tinctness, words which he could not pronounce when asked
to do so. In his writing there was often a tendency to re-
duplication of letters. For instance, he wrote ' Testata-
ment ' for ' Testament.' But I cannot say whether this
was more than the result of deficient education.

* Aphasia and Agraphia. St. George's Hospital Reports, vol. ii., 1867, p. 105.

198

DISEASES OF THE BRAIN.

" His mind seemed quite clear. He miderstood all that
was said to him; took interest in all that was going on
about him ; listened to conversation with an animated,
lively look, laughing at any little joke, and expressing
himself frequently by suitable pantomime. In Decem-
ber he was attacked by oedema of the lungs, and died on
the 20th.

Post-mortem ; oedematous lungs, extensive aortic and mi-
tral disease. " Much semigelatinous fluid in subarachnoid
space. Surface of brain healthy, excepting at one limited spot.
This was the posterior part of the third frontal convolution
on the left side. Here was a softened, almost diffluent patch
about three-quarters of an inch in breadth, reaching from
the highest point of the third convolution backward and
downward to the fissure of Sylvius. The softened patch
was not actually the most posterior part of the convolution,
for there was a narrow unsoftened strip between it and the
transverse frontal convolution. In cutting into the brain, a
second small patch of softening was seen in the centre of the
left hernisphere, external to and rather above the corpus stri-
atum, and extending toward the posterior termination of the
fissure of Sylvius. All the rest of the brain was apparently
healthy.

" The left middle cerebral artery was firm in its main
trunk, but in one of its secondary branches at a bifurcation
was a hard shotty bit of fibrin e completely obstructing the
passage, so that when water was injected into the vessel it
could not pass, though considerable force was used. There
were also fibrinous blocks in the spleen."

The theory of M. Marc Dax locates the faculty of speech
in the left hemisphere. He based this opinion upon the fact
that aphasia is associated almost, if not invariably, with
right hemiplegia, when there is any paralysis at all. That
this is really the case is beyond question. "Without, how-
ever, referring again to the cases cited by M. Dax, I quote
the following table from Dr. Seguin's paper :

APHASIA.

199

APHASIA WITH HEMIPLEGIA.

AUTHOEITLES.

lligbt
Heraiplegia.

Left
Hemiplegia.

Trousseau, 1865 (Acad, de Med.)

125

Baillarger, later in 1865 (Salpetriere)

Jackson, loc. cit

Robertson, loc. cit

Medical Times and Gazette, September 9, 1865. .

Archives Gen. de Med., 1866

Flint, New York Medical Record, vol. i

New York Hospital, 1830-'6'7

Total

243

From this table we learn that, of two hundred and sixty
cases of aphasia associated with paralysis, the left hemisphere
— as determined by the situation of the hemiplegia — was the
seat of the lesion in two hundred and forty-three cases, and
the right in only seventeen.

I also quote the following table from Dr. Seguin :

QUESTION OF LEFT ANTERIOR LOBE.

AUTOPSIES BY

For.

Against.

Marc Dax, in 1861, and G. Dax (Acad, de Med.,

1863)

Bouillaud, 1848

370
85
31
18
5
2
3

5
4

" 1865

Trousseau (Acad, de Med.)

Vulpian (Le9ons de Phys.)

New York Hospital, 1830-'67

Jackson, Richardson, A. Clark, 1866, 1867

Peter, Legrand, Beclard, Delpech, Berard, one

Farge, Bigelow, Detmold, and Stokes, one each . .

Total

614

This table is based on autopsies, and may be cpnsidered
conclusive as to the relative frequency with which aphasia
is connected with disease of the left anterior lobe.

From various sources I have obtained the following ad-
ditional cases, in which the seat of the lesion was determined

200 DISEASES OF THE BRAIN.

either by post-mortem examination or by the situation of
tbe hemiplegia :

AUTHORITIES.

Larrey

Falret

Perroud

Magnan

Carrier

W. Ogle

Bartholow

Bateman

W. Wadham

Total

The immense preponderance of disease of the left hemi-
sphere, and especially of its anterior lobe, as a concomitant
of aphasia, is therefore placed beyond a doubt. Indeed, so
far as I am aware, the fact is not questioned. How, now, is
it to be explained ?

We cannot claim, even with all the disparity of cases,
that the organ of language is located in the left anterior
lobe, or even in the left hemisphere, to the exclusion of
the other. Broca has attempted to account for the as-
sumed restriction, on the ground that the left hemisphere
receives a larger supply of blood, and is earlier developed
than the right. This is doubtless correct, but still the fact
remains that lesion of the right hemisphere is sometimes
followed by aberrations of speech ; the left remaining per-
fectly healthy. One such case — and there are several on
record in which the autopsy confirmed the deductions drawn
from the symptoms — is sufficient to overturn the theory
which restricts the situation to one side of the brain ; and
one such" as that reported by Dr. Simpson,* in which there
was extensive lesion of the third left frontal convolution
in its posterior part, and no epilepsy, paralysis, or aberra-

1 Medical Times and Gazette, December 21, 1867.

Left
Hemisphere.

Right
Hemisphere.

6
30

APHASIA.

201

tion of speech, is of course utterly destructive of Broca's
views.

The fact that aphasia is more frequently conjoined with
right hemiplegia is undoubtedly due mainly to the fact pre-
viously insisted upon in my remarks on cerebral embolism,
that the left middle cerebral artery is much more liable to
be plugged by an embolus than the right ; and it is by em-
bolism that aphasia is generally caused. Dr. Hughlings
Jackson * has very satisfactorily worked out the relation,
and my own experience, presently to be related, abundantly
confirms the fact.

At the same time it appears to be clearly shown that the
left anterior lobe, or rather, in accordance with Dr. Jack-
son's views, those parts of the brain nourished by the left
middle cerebral artery, are more intimately connected with
the faculty of articulate language than any other region of
the encephalic mass. It is probably true, as originally ad-
vanced by Dr. Moxon,^ and since urged by Dr. William
Ogle,' that the organ of speech is to be found in both hemi-
spheres, and that one side is more generally employed than
the other, just as we ordinarily give a preference to one eye
or one ear or one hand, and that this side is the left. Gra-
tiolet's facts, adopted by Broca to support his view of exclu-
siveness, will certainly lend force to the argument in favor
of preference. This careful anatomist found that the left
hemisphere is developed before the right, and that it is bet-
ter nourished. Both of these circumstances are owing to
the greater supply of blood which it receives.

Undoubtedly many of the cases which have been brought
forward as militating against the doctrine of localization
of the organ of speech are not cases of aphasia at all, but
simply instances of inability to speak, from paralysis of the

* London Hospital Reports, vol. i., 1. c.

' On the Connection between Loss of Speech and Paralysis of the Right Side.
British and Foreign Medico-Chirurgical Review, April, 1866, p. 481.

' Aphasia and Agraphia. St. George's Hospital Reports, vol. ii., p. 83.

202

DISEASES OF THE BRAIN.

muscles concerned in speech. This is certainly true of the
greater number of Seguin's cases, and also, as Bartholow ^ has
stated, of those adduced by Ladame.

Again, in very many instances ■ the post-mortem exami-
nation has not been properly made, and lesions involving
one or the other anterior lobe have been overlooked. It is
now a well-recognized fact that the cerebral tissue may be
materially diseased, and the lesion not be detected without
microscopical examination.

Giving a very full consideration, therefore, to the facts
and arguments which have been urged on all sides of the
question, I am constrained, while rejecting the restricted
location of MM. Dax, and the still more limited situation
contended for by Broca, to believe :

1. That the organ of language is situated in both hemi-
spheres, and in that part which is nourished by the middle
cerebral artery.

2. That while the more frequent occurrence of right
hemiplegia, in connection with aphasia, is in great part the
result of the anatomical arrangement of the arteries which
favors embolism on that side, there is strong evidence to
show that the left side of the brain is more intimately con-
nected with the faculty of speech tlian the right.

These views are further supported by several interesting
cases, the histories of which I now propose to relate :

Case I. — In the summer of 1857, while I was on duty, as
medical officer of the army, with a body of troops and to-
pographical engineers, making a road from Fort Riley to
Bridger's Pass, in the Rocky Mountains, a quarrel occurred
between two of the laborers, which resulted in one of them
striking the other a violent blow on the head with a club.
The injured man fell to the ground stunned, and remained
in a state of coma for several hours. Upon examining him
a few minutes after the affair took place, I ascertained that

1 On Aphasia. Journal of Psychological Medicine, etc., vol. ii., p. 341,
et seq.

APHASIA.

203

there was no stertor and no indication of paralysis. He
was unconscious and breathing quietly, with a pulse of
about 80. He had received a blow on the left temple,
which, though laying open the scalp, had not fractured tlie
skull. Gradually he regained consciousness so as to be able
to comprehend what was passing about him, but he had en-
tirely lost the memory of words, though not the faculty of
articulation. Thus he was unable to speak unless the words
were first repeated to him, and then he could do so without
any defect of articulation, provided too many words were
not given to him at once.

Thus, when I said to liim in Spanish — he was a Mexican,
and could not speak English — " Como sientes ahora ? "
"How do you feel now?" he repeated, "Como sien. sien.
sien.," and then, looking at me in apparent despair, burst
into tears. And this was repeated time and again during
the hour I spent with him.

• The next morning, at about seven o'clock, as he attempt-
ed to rise from his bed, he fell, and was found a few min-
utes afterward by the hospital attendant, lying on the ground
in a state of complete coma. I saw him almost immedi-
ately ; he was breathing stertorously, blowing out his lips
and cheeks at each expiration, and exhibiting a general res-
olution of all his limbs. He died at about eleven o'clock
A. M. that day.

That afternoon I made a post-mortem examination. On
removing the calvarium, the first thing that attracted my at-
tention was an ecchymosed spot about the size of a half-dol-
lar-piece involving the left anterior lobe at its lateral and
posterior margin. There was no extensive hremorrhage at
this point. But, on the opposite side, there had been a rup-
ture of the middle meningeal artery, and an immense ex-
travasation of blood which had infiltrated between the lobes
of the right hemisphere and collected in the base of the skull.
My theory of the case was that the haemorrhage from the
artery had been suddenly stopped during the condition of

204

DISEASES OF THE BRAIN.

primary insensibility before any considerable quantity of
blood had been effused, and that during the night his heart
had recovered its power ; and this, with the muscular effort
he made in attempting to get out of bed, had dislodged the
coagulum, and allowed the haemorrhage to take place. At
that time I attached no especial importance to the injury of
the left anterior lobe ; but, since the debate in the French
Academy in 1861, I have had no doubt that to it the amne-
sic aphasia was entirely due.

It will be observed that there was no defect of articula-
tion in this case, either from paralysis or incoordination, but
that the diflSculty was solely as regarded the memory of
words.

Case II. — J. H., a captain of a coasting-vessel, consulted
me in I^ovember, 1864, for a difficulty of speech with which
he had been affected for several months. Upon inquiry, I
ascertained that one morning early he had been called from
his bed upon some duty connected with his vessel ; that he
had risen rather hastily and gone on deck ; that while giv-
ing an order he suddenly became very dizzy, and fell, uncon-
scious. He soon regained his senses, but found that he was
paralyzed on the right side, and had lost the ability to speak.
He soon afterward reached port, and remained at home for
three months, during which period the paralysis disappeared
almost entirely, and he reacquired the ability to speak. The
aphasia was of both the amnesic and ataxic forms. He could
neither speak nor write.

He then went to sea again as a passenger to Cuba, and
while in Havana had another attack similar to the first, but
without paralysis of motion, though there was loss of sensi-
bility on the right side. The memory for words was en-
tirely destroyed, though he could pronounce distinctly any
word he was told to say, if he did not allow too long a
period to elapse between the direction and the response.
About four months after his last seizure he consulted me.

At this time he could say a few words, and he employed

APHASIA.

205

them to express all his ideas, assisting himself with very en-
ergetic gestures, which, however, were rarely expressive of
his thoughts. The words he thus constantly used were " sifi,"
which signified both yes and no, and " time of day," which
he employed when he had any other answer than simple
affirmative or negative to give. Besides these expressions,
he had an oath, " Hell to pay ! " which he ejaculated when-
ever he did not succeed in making himself understood, and
sometimes without any siich exciting cause. These were
the only expressions he could originate, but he could pro-
nounce distinctly any word he was told to say, and even as
many as three short successive words. When told to write,
he took the pen, and, on my telling him to give me his name
and address, wrote " Time of day," and then, seeing that that
was not the correct answer, immediately followed it with
" Hell to pay ! " On my remarking to him that he had given
me wrong information, he immediately wrote " sifi." Any
word, however, which I told him to write, he did without any
difficulty, and thus I obtained several long sentences from him.

From his brother, who came with him, I obtained the
facts in his history I have mentioned. Examining his heart,
I found that he had a strong systolic murmur, and was told
by his brother that he had had, fifteen years ago, a first at-
tack of acute articular rheumatism, which had been followed
by several other attacks.

The main point of interest about this case — and it is
one of those I shall again draw attention to — is, the occur-
rence of ataxic aphasia with hemiplegia as concomitants of
the first attack, while the second was characterized by pure-
ly amnesic aphasia and no paralysis.

Case III. — During the winter of 1868-'69, a man came
to my clinique, at the Bellevue Hospital Medical College,
who was aphasic, and from whose friends, his own gestures,
and the few words he could speak, I obtained the following
history : Some months previously he had been working in a
stone-quarry, and was struck by some piece of machinery on

206

DISEASES OF THE BRAIN.

the left side of the head, at about the junction of the frontal
with the temporal bone. For a short time he was uncon-
scious, recovering, however, without paralysis, but with loss of
the memory of words. When he came under my observation,
he was very intelligent, comprehended every word said to
him, and made repeated and persistent efforts to talk, but
he could not utter a word spontaneously beyond "yes" and
" no," which he always used correctly. Thus, when I asked
him where he was born, he became much excited, gesticu-
lated violently, and apparently made every effort to tell me.
The perspiration stood out in large drops on his forehead,
but no sound came from his lips. Then the following con-
versation took place :

" Were you born in Prussia ? " " No."

"In Bavaria?" "ISTo."

"In Austria?" "No."

" In Switzerland ? " " Yes, yes, yes, Switzerland, Swit-
zerland," at the same time laughing, and moving his hands
actively in all directions. He could pronounce words well,
but could not write.

I took occasion to speak at length on the subject of apha-
sia, and gave it as my opinion that there had been a fracture
of the internal table of the skull, and that a fragment of
bone was pressing on the posterior and lateral part of the
anterior lobe. My friend Prof. Sayre was present, and I
advised him to trephine the patient, with the view of elevat-
ing any depressed piece of bone, and restoring the normal
function of that part of the brain. The operation was per-
formed a few days afterward, the patient being placed un-
der the influence of ether. The internal table was found to
be fractured, and a splinter was pressing on the posterior
frontal convolution. It was removed, and, as soon as the
patient emerged from the anaesthetic condition, he spoke
perfectly well.

This, as will be seen, was also a case of amnesic aphasia
unaccompanied by paralysis.

APHASIA.

207

Case TV. — A. E,, formerly a bookseller, consulted me in
tlie autumn of 1869 for what was considered by his friends
to be, and what probably was, softening of the brain. Be-
fore any symptom of disease appeared, he had been noted
for his remarkable memory, but was now exceedingly for-
getful, especially as regarded words. Thus he had forgotten
his first name, and could not tell me the names of his chil-
dren. His conversation was marked by great hesitancy,
from his not remembering the words he wished to use, and
there was, besides, marked difficulty of articulation, and
some words he could not pronounce at all. There was right
hemiplegia, which had gradually been getting worse, and
which, when I saw him, was extensive enough to interfere
materially with the movements of his arm and leg. The
left side was not affected, and the tongue and face were ap-
parently not paralyzed. He was subsequently lost at sea in
the steamer City of Boston.

This case, therefore, exhibited both the amnesic and
ataxic forms of aphasia, and was accompanied by right
hemiplegia. I regard the condition as being due to throm-
bosis, probably of the left middle cerebral artery.

Case V. — W. W., aged forty-one, entered the iN'ew York
State Hospital for Diseases of the N^ervous System, August
22, 1870, hemiplegic on the right side, and affected with
ataxic aphasia. In the month of March, 1868, as ascertained
by Dr. Cross, the resident-physician of the hospital, he was
seized with a dull pain in the right knee, accompanied with
numbness, formication, and pricking sensations, limited to
the right foot, while general numbness of the whole side soon
supervened. These, with loss of power, gradually extended
and increased till at the end of two weeks the patient was
entirely hemiplegic. There was at no time any loss of con-
sciousness nor any mental aberration. On the 11th of May
following, the patient suddenly lost the power of speech, but
his mind remained perfectly clear, and, though he could not
utter a word, he understood well every thing that was

208

DISEASES or THE BRAIN.

said to him. He remained nearly completely apliasic for
four months, being only able during that time to utter a few
sounds, which could not be interpreted into intelligible words.

About September, 1868, he began to enunciate a few
words, at first very slowly and indistinctly, and gradually
acquired more facility. "When I presented him before the
class at the Bellevue Hospital Medical College, in JSTovem-
ber, 18T0, although he could talk, his power of coordination
was very imperfect, and many words were articulated with
great difficulty. This trouble was chiefly manifested in re-
gard to labials and Unguals, such words as " truly rural,"
" Peter Piper," " baker," and others of the kind, causing him
to make repeated efibrts before he could even imperfectly
pronounce them. There was no paralysis of the tongue, no
deviation when it was protruded, and but very slight if any
paresis of the orbicularis oris or other facial muscles. The
arm and leg on the right side were profoundly paralyzed.

In this case there was no loss of the memory for words,
and no difficulty in writing. It was, so far as the aphasia
was concerned, entirely ataxic in character, and accompa-
nied by right hemiplegia.

My opinion was, that the symptoms were to be attributed
to thrombosis of the left middle cerebral artery.

Case YI. — R. M., aged twenty-five, noticed one day that
his right foot was unusually cold. A few days afterward
he had his first attack of hemiplegia of the right side. Sud-
denly, and without the least warning, except a severe ver-
tigo, he fell, but immediately arose. There was no loss of
consciousness, and with assistance he was able to walk to
his residence, a short distance off. His face was drawn to
the left side, and speech and memory were slightly impaired.

In February, 1869, having recovered motility, he was
seized with another attack of right hemiplegia. This time
he partially lost consciousness, and his speech again became
affected. By April, 1869, he was able to resume his work
as a weaver, but his arm M^as still weak.

APHASIA.

209

In July lie had another attack, which was slight.

In May, 18T0, he again suddenly became heniiplegic on
the right side. There was no loss of consciousness. The
face and tongue were affected. With assistance he walked
home, and in a week had quite recovered.

In July, 18Y0, he had his fifth and thus far last attack.
While chopping wood he was suddenly seized with a violent
pain in the head, followed by vertigo. He fell, but did not
lose consciousness. There were right hemiplegia again, dif-
ficulty of speech, and dilatation of the left pupil. For five
days afterward he was delirious, but finally recovered, with
loss of power in the right arm and leg, and increased difii-
culty of speech. September 1st, he was admitted to the
New York State Hospital for Diseases of the JS'ervous Sys-
tem. At this time the paralysis had entirely disappeared ;
the tongue could be moved freely in any direction, and his
articulation was perfect. But his memory for words was
greatly impaired, though facts and circumstances were re-
membered perfectly well. His speech was therefore hesi-
tating, and if asked to repeat a sentence of three or four
words he could not do it. Thus he could not repeat the
words " sugar, cofiee, crackers," although he began immedi-
ately after I had finished saying them.

Examination showed that the patient had hypertrophy
of the heart, with aortic insufficiency.' My diagnosis was,
repeated attacks of embolism of the left middle cerebral
artery, or its branches.

This case was one of partial amnesic aphasia, with ataxic
aphasia, which had disappeared with the hemiplegia.

Case YII. — Mrs. S. H. W., aged thirty-two, married.
On the 26th of June, 1860, about three weeks after the
birth of her child, she was suddenly seized with a severe pain
in the right shoulder, which extended down the arm. Symp-

' I have condensed the histories of this and the preceding case from the re-
ports of Dr. Cross, in my clinical lecture on Partial Cerebral Anaemia, published
in the Journal of Psychological Medicine for January, 18V1.
14

210

DISEASES OF THE BRAIN.

toms of albuminuria, accompanied by general dropsy, im-
mediately ensued, and in a few weeks the dyspnoea from
hydrotborax was alarming. Coma and a convulsion fol-
lowed. Soon after tbe fit, which marked the height of her
disease, as she was sitting by the bed, resting her head on
her folded arms, her right side became completely paralyzed,
and she lost the ability to speak. She was not entirely
clear in her mind for a week after the attack, but gradually
the dropsy disappeared, her intellect improved, and the pa-
ralysis became less.

At the time of the seizure, the face was drawn to the
right side, the tongue deviated in the same direction, and
there were strabismus and partial ptosis and paralysis of the
orbicularis palpebrarum muscle on the right side. Motility
and sensibility in the right arm and leg were, at first, com-
pletely abolished, but at the end of ten days she was able to
move about, by holding on to a chair. During three years
she continued to improve as regarded the paralysis, but for
all that period did not speak a word. In the summer of
1863 she became able to say the word "no," and a few
months later she could say " yes."

At my request, she allowed me to present her before the
class of the Bellevue Hospital Medical College, in Novem-
ber, 18Y0, on the occasion of a clinical lecture on aphasia.

She was then, and is now, enjoying good health, with
the exception of frequent headache. Her countenance is
remarkably bright and cheerful,, and her whole expression
is exceedingly intelligent. She comprehends every word
that is said to her, and attends to all her household duties.
Yet she is unable to utter any words but " no," " yes," and
" dado." The latter is seldom employed, but in her vocabu-
lary signifies afiirmation. She uses "yes" for affirmation,
" no " for negation, and both for doubtful or indifferent con-
ditions. Thus, if asked how she is, she answers " Yes, yes,
no, no," which means that she is tolerably well. Sometimes
she employs these words quite indiscriminately. If asked

APHASIA. 211

what that is, pointing to a fan, she cannot tell, nor can
she repeat the word fan. She shows, however, that she
knows, by making the gesture of fanning herself. She can
neither read nor write, although on one occasion she suc-
ceeded, after great difficulty, in writing "no." !N^ot long
since, she suddenly ejaculated, " I don't know ! " and a few
days ago exclaimed, " How do you do ? " but she was not
able to repeat either of these phrases, nor did she appear to
be aware that she had said them. Her gestures are very in-
telligent and expressive. The right arm and leg are weaker
than on the left side, and the sensibility is less.

There is a murmur at the apex of the heart with the first
sound.

Ophthalmoscopic examination showed the vessels of the
retina of the left eye to be much larger than those of the
right.

In this case I diagnosticated embolism of the left middle
cerebral artery.

The aphasia was of both the amnesic and ataxic forms,
and was accompanied by right hemiplegia.

Case YIII. — Mr. B. consulted me in November, 1870,
for loss of the memory of words, and fulness and pain in
the head, with occasional vertigo. Over a year previously,
while in the woods of Minnesota buying timber, he had sud-
denly lost consciousness for a few moments, and on recover-
ing found that he had become hemiplegic on the right side,
and had lost the power of speech. For a short time he
could not utter a word, but gradually the memory of lan-
guage, and the ability to coordinate the muscles of speech,
returned to him, and he could articulate sufficiently well to
be understood. For several months, however, his recollec-
tion of words was bad.

For some time he had been under the care of Dr. Hale,
of Chicago, a homoeopathic physician, who advised him to
place himself under my charge. When I first saw him, he
could talk quite well, but there was still a hesitancy in his

212 DISEASES OF THE BRAIN.

speech, and occasionally words were misplaced or miscalled.
Articulation was distinct, and the hemiplegia had disap-
peared. There was pain, almost entirely confined to the
left temporal region. There was the history of acute ar-
ticular rheumatism, and there was aortic insufficiency.

In this case there had been at first amnesic and ataxic
aphasia, with right hemiplegia. As the latter disappeared,
the ability to coordinate the muscles of speech was increased,
until at last articulation became perfect, and only amnesic
aphasia remained.

Case IX. — II. I., a merchant, consulted me in August,
1869, for hemiplegia, with inability to speak. While sitting
at his desk, six weeks previously, he suddenly became ver-
tiginous, and lost consciousness for a few moments. On re-
covering his senses, he discovered that he was paralyzed on
the right side, and that he could not speak a word. He was
exceedingly anxious to make known some wish, and one of
his clerks brought him paper and a pencil, but he could not
write a letter. An alphabet was then written, but he was
unable to select the letters to form the words he wanted to
use.

A physician was sent for, and Mr. I. was bled to the ex-
tent of sixteen ounces, without any favorable result. He
remained hemiplegic and completely aphasic for about two
weeks. He then began to walk, and acquired the ability to
say " what," " certainly," and " saw my leg off," which he con-
tracted into " sawmelegoff," accentuating strongly the ulti-
mate syllable. These words he used without apparent in-
telligence, though he clearly understood all that was said to
him, and laughed at any joke as heartily as ever. His con-
dition was about the same when I saw him.

He could protrude his tongue, and move it actively in
all directions, but could not articulate any words but those
mentioned. Thus, when I asked him to say "table," he
said, " Certainly ; " and when I said, " Well, say it then," he
exclaimed, " Sawmelegoff! " at the same time, to show that

APHASIA. 213

he understood what I said, he went across the room, and
put his hand on a table, uttering, at the same time, his full
stock of words, " what," " certainly," sawmelegoff*."

I then asked him if he could write ; he replied, " Cer-
tainly." I placed paper before him, and gave him a pen
with ink, but lie was unable to write his name as I re-
quested, although he could use his fingers for other things
tolerably well. I asked him to draw a series of parallel
lines, and he did so without difficulty. On my insisting that
he should now make an effort to write his name, he made
the attempt with this result :

Fig. 7.

I told him that was not his name, at which he gesticulated
violently, exclaimed, " Sawmelegoff! " and gave me one of
his visiting-cards. This gentleman continued under my care
for some time, but with no perceptible change. He had
had two attacks of acute articular rheumatism, and had,
when I saw him, both aortic and mitral insufficiency.

Here, then, was right hemiplegia, with fully-developed
ataxic and amnesic aphasia. My diagnosis was, embolism
of the left middle cerebral artery.

Case X. — Miss C. E.., of strongly-marked hysterical
diathesis, suddenly became aphasic while sitting at the
breakfast-table. I saw her about two hours subsequently,
wlien she drove to my office with her mother. There was
no paralysis, the tongue could be moved freely in all direc-
tions, articulation was perfect, and she could pronounce
any word mentioned before her. The memory of words
was, however, entirely abolished.

Case XI. — Mr. S., a retired merchant, consulted me in
September, 1870, for the effects of cerebral haemorrhage.
He was hemiplegic on the right side, and unable to talk.

214

DISEASES OF THE BRAIN.

His intelligence was good. He could read, but he "was not
able voluntarily to pronounce a word. The tongue was not
in the least paralyzed, nor had it been. Occasionally ejacu-
lations of various kinds would come forth. On one occa-
sion, as he entered my office, he exclaimed — he was a Ger-
man gentleman — " Guten Morgen, mein Herr," but by no
effort could he repeat that or any other expression. His
attempts to speak were continuous while he was with me ;
and his son who came with him said he was almost always
trying to talk while he was not sleeping.

This case was, therefore, one of ataxic aphasia, and
was marked by the existence of right hemiplegia. Cere-
bral haemorrhage, involving the corpus striatum, was the
cause.

Case XII. — Mr. L. IT., a German gentleman, came under
my care in September, 1869, for symptoms indicative of cere-
bral softening. He was slightly paralyzed on the right side.
His speech was affected both amnesically and ataxically.
Soon afterward, in consequence of maniacal symptoms mak-
ing their appearance, I sent him, with the concurrence of my
friend Prof. Flint, to the Lunatic Asylum, at Flushing. He
remained there till September of the present year, gradually
failing in mental and physical power, when, as he was no
longer in a condition to injure himself or others, his friends,
with my approval, removed him to their own home. At
the present time he can scarcely remember a word, and his
articulation is very defective. A remarkable feature of his
conversation is that he calls every thing " kazze," " cat."
He appears to have forgotten every other word.

The history of this case points to thrombosis as the prob-
able lesion.

Case XIII. — This was a very remarkable and instructive
case, one which I have already mentioned under the head of
embolism.

The patient was a retired officer of the army, and con-
sulted me in the autumn of 1869 for paralysis, vertigo, and

APHASIA.

215

slight difficulty of speaking, from wliich he had suffered for
some months. Several years previously he had been un-
der the care of my friend Dr. Metcalfe for acute rheumatism,
with cardiac complications. The liistory of the case pointed
strongly to embolism, and, as the paralysis involved the
right side, I diagnosticated a previous attack of embolism of
the left middle cerebral artery.

The difficulty of speech was slight ; there were both am-
nesic and ataxic aphasia.

Under the treatment employed he improved very much
in the ability to walk, to use his arm, and to speak, so much
so that he and his friends considered him better than he had
been for several years. But about six weeks after he came
under my charge he had another attack. This time the left
side was paralyzed, and there was no difficulty of speech.
Galvanism was employed, as before, and he recovered suffi-
ciently to go to Washington City. While there he had a
third attack, characterized by right hemij)legia and aphasia.
He soon recovered his power of speech, and soon afterward
had a further attack, involving the left side, and unattended
by aphasia. He recovered under the care of Dr. Basil Norris,
of the army, and soon afterward came again to l^ew York.
A short time after his arrival I requested my friend Prof. Flint
to see him in consultation, with the special view of having
him examine his heart. This was done with thoroughness, but
no abnormal sounds were detected. While in New York he
had two other attacks, during both of which he was deliri-
ous ; both were characterized by hemiplegia. That of the
left side was unaccompanied by aberrations of language ;
that of the right was attended with ataxic and amnesic apha-
sia. He forgot the names of the most ordinary things, and
there were many words that he could not articulate at all.
Thus, when he wanted a fan, he called it " a large, flat thing to
make a wind with." He forgot my name, and could not pro-
nounce the words beetle, general, physician, and many others.
I sent him to JSTewport greatly improved, but he had other

216

DISEASES OF THE BRAIN.

attacks there, and finally died in tlie autumn of the present
year, of, I presume, cerebral softening.

The interesting features of this case are the concurrence
of hemiplegia and ataxic and amnesic aj)hasia, and the strik-
ing fact that there was no aphasia when the paralysis in-
volved the left side. Thus, according to my views of the
case, the patient had repeated attacks of cerebral embolism.
"When the embolus lodged in the left middle cerebral artery,
there was aphasia accompanied by right hemiplegia ; when
the embolus obstructed the right middle cerebral artery,
there was left hemiplegia, but no aphasia.

Case XIY. — In the early part of December, 1870, J. M.,
a patient of Bellevue Hospital, was, at his request, brought
to my clinique at the college. His history, as given me by
Dr. Judson, showed that he had repeated attacks of uncon-
sciousness or semi-unconsciousness, which were accompanied
with hemiplegia. Dr. Flint had also detected a bellows
murmur, but it was at the apex of the heart. The patient
had suffered from several seizures of acute articular rheuma-
tism.

Upon inquiry, I ascertained that he had had altogether
eleven attacks of vertigo, unconsciousness, and hemiplegia.
His intelligence was good, and he spoke tolerably well,
though with hesitation and occasional difficulty of articula-
tion. His speech was much better than it had been, and
there was no well-marked hemiplegia.

As in the case last mentioned, whenever the hemiplegia
had been on the left side there was no aphasia, but when it
was on the right side there was always well-marked difficulty
of speech, both amnesic and ataxic.

The only other case, similar to these last two, that I have
been able to find, is one reported by Dr. Stewart,'" of a man
who was admitted into the Middlesex Hospital, suffering
from left hemiplegia, without aphasia. A week later he be-
came affected with right hemiplegia and loss of speech. He

' Medical Times and Gazette, July 9, 1864.

APHASU.

21Y

died, and on post-mortem examination both middle cerebral
arteries were found plugged with emboli.

The views which the cases I have observed have led me
to form, have been confirmed by my recent study of the sub-
ject of aphasia. These have already been given in part,
but the detail of the foregoing histories enables me to ex-
press the remainder with more confidence.

It cannot have failed to strike the reader that, in all the
cases of which hemiplegia formed a feature, the aphasia was
of the ataxic form, while when there was no hemiplegia the
aphasia was amnesic. In the one the individual was de-
prived of speech because he could not coordinate the muscles
used in articulation, in the other because he had lost the
memory of words.

This is a point which has not hitherto been noted. The
phenomena indicate, I think, very clearly the seat of the
lesion, and the physiology of the parts involved.

The gray matter of the lobes presides over the idea of
language, and hence over the memory of words. When it
only is involved, there is no hemiplegia, and there is no diffi-
culty of articulation. The trouble is altogether as regards
the memory of words.

The corpus striatum contains the fibres which come from
the anterior column of the spinal cord, and is besides con-
nected with the hemisphere. A lesion, therefore, of this
ganglion, or other part of the motor tract, causes paralysis
of motion on the opposite side of the body. The cases I
have detailed show, without exception, that the power of
coordinating the muscles of speech is directly associated
with this hemiplegia. A lesion, therefore, followed by hemi-
plegia and ataxic aphasia, indicates the motor tract as the
seat. If amnesic aphasia is also present, the hemisphere is
likewise involved. An analysis of the cases reported by
Ogle, Jackson, and some other observers, shows that the
association existed in their cases, although they have not
noticed it as of any physiological or pathological bearing.

218

DISEASES OF THE BRAIN.

Another important feat;ure of the foregoing cases is the
constant association of the aphasia with right hemiplegia
where there was any paralysis at all. This indicates, per-
haps, only the more frequent occurrence of embolism on the
left side, but the last two cases, as well as the one quoted
from Dr. Stewart, show that the left hemisphere is more in-
timately connected with the faculty of speech than the right.
In fact, it appears to me impossible to avoid this conclusion.

So much for some of the various theories which exist
relative to the localization of the organ of language and
for the clinical history of aphasia, I have not thought it
necessary to discuss the view of Schroeder van der Kolk,'
that the faculty of articulate speech resides in the corpora
olivaria, because there is little if any physiological or patho-
logical evidence to sustain it. Kor the hypothesis of Brown-
Sequard," that speech is a reflex phenomenon, because there
is no evidence in support of that opinion. JSTeither have I,
though much tempted, ventured into the philosophy of the
subject to any considerable extent.

As to the causes, the prognosis, diagnosis, morbid anat-
omy, and pathology, they have been sufficiently considered
in the remarks made, and the treatment is of course that of
the pathological condition to which it is due, whether this
be cerebral haemorrhage, embolism, thrombosis, softening,
hysteria, wounds, the bites of poisonous serpents, or other
cause. One point, however, should be mentioned in this
connection, and that is, that constant efforts should be made
to exercise the vocal organs, by attempts to speak, and by
the application of the galvanic or faradaic currents to the
tongue and other muscles concerned in articulation.

' On the Minute Structure and Functions of the Spinal Cord and Medulla
Oblongata. New Sydenham Society Publications, p. 140.
* Seguin's Memoir, already quoted

CHAPTER YIII.

ACUTE CEREBRAL MENINGITIS.

By acute cerebral meningitis is understood inflammation
of two membranes of the brain — the pia mater and arach-
noid. Some writers have made the attempt to discriminate
between inflammation of the arachnoid and inflammation
of the pia mater, but there are no diagnostic marks by
which such a distinction can be made, and we find from
post-mortem examination that neither membrane can be
inflamed without the other participating in the morbid pro-
cess. Inflammation of the dura mater is never included un-
der the term meningitis.

The ancients made no distinction between the several
inflammatory affections of the intra-cranial organs, but com-
prehended them all in one disease which they called frenzy
— ^pr]v^ the brain. Morgagni, however, showed that the
membranes of the brain were the parts generally involved,
and gave a very accurate account of the phenomena of an
attack of acute meningitis. Since then, Rostan, Lallemand,
Andral, Bouillaud, and others, have added to our knowl-
edge.

Symptoms. — The symptoms of acute cerebral meningitis
may be divided into three grouj)S, arranged in chronological
order : the stage of invasion, the stage of excitation, and
the stage of collapse.

1. The Stage of Invasion, — The most prominent initia-
tory symptom is headache, which may be diffused or con-
fined to a limited part of the head. When this latter is the

220

DISEASES OF THE BRAIN.

case, the frontal region is more generally its seat ; next in
order of frequency is the occipital, and next the temporal.
At the same time, the face is flushed, the eyes are red and
suffused, and there is a decided elevation in the temperature
of the head, which is not only felt by the patient, but may
be perceived by the hand of the physician. Vomiting is
generally present.

As might be expected, these symptoms are accompanied
by fever. This, however, rarely runs high, so far as the force
or the frequency of the pulse is concerned, or as regards
the heat of the skin. It is mainly characterized by restless-
ness and insomnia. Occasionally there is a tendency to
somnolence.

This stage may last a few days or only a few hours, or
may be so slight as not to attract attention. In general fea-
tures it resembles the prodromatic stage of cerebral conges-
tion.

2. Stage ok Period of Excitement. — A chill ushers in
this stage, and an increase in the intensity of several of the
symptoms of the first stage, and the development of others,
soon take place. Thus the fever becomes higher, the skin
hotter, and the temperature of the body is elevated sev-
eral degrees. The pulse is frequent, quick, and hard, and
the face becomes redder than in the first stage. The pain
in the head augments in violence, and is increased by press-
ure on the scalp, or even the slightest movement.

The eyes are bright, the pupils contracted and painfully
sensitive to light. The hearing becomes morbidly acute,
loud noises cause great agony, and even slight sounds are
unbearable. The general sensibility of the body is increased,
and hence the patient is rendered uncomfortable by the con-
tact of the bedclothes with the skin. Delirium is generally
present from the first, and is often of furious character.
Hallucinations of sight and hearing are almost constant, and
the irrationality of the ideas is marked by the incoherence
of the speech. The patient when awake is continually talk-

ACUTE CEREBRAL MENINGITIS.

221

ing, gesticulates violently, and weeps and laughs alternately
over imaginary evils. It is sometimes necessary to use re-
straint to prevent him injuring himself or others, and the at-
tendants should always be prepared for any emergency of
the kind. As the disease advances, the delirium becomes
more subdued, and the patient may exhibit some evidences
of sanity.

Even when there is no delirium, as occasionally happens,
the influence of the morbid action over the mind is shown
in the irritability of the patient, and the change which lie
undergoes in character and disposition.

Convulsions rarely occur in adults, but motility generally
is nevertheless disordered. The limbs are in almost continual
action, as are likewise the jaw and the eyelids. Twitchings
of the facial and other muscles, such as those of the forearm,
are usually well marked, and occasionally there are irregu-
lar movements of the eyeballs. Convulsions, when they oc-
cur, may be either clonic, or tonic, or both. Thus there
may be a gradually-increasing rigidity of some muscles, fol-
lowed by relaxation and disordered movements. Sometimes
there is opisthotonos as well marked as in some cases of
tetanus. Hemiplegia or paraplegia may occur, but are in-
frequent complications. I have seen two cases in which one
lateral half of the body was paralyzed during the whole
course of the disease.

Contractions of the limbs sometimes take place, and may
be confined to one side or a single limb. In this case the
forearm is usually strongly flexed on the arm.

The muscles of organic life participate, and the bowels
are obstinately constipated. There may be difiiculty of swal-
lowing, from spasm of the pharynx, and irregularity of breath-
ing, from implication of the respiratory muscles.

The most characteristic symptom of this stage is, how-
ever, the obstinate and violent cephalalgia, of which mention
has already been made, and yet there are cases in which it
is entirely absent from first to last. Several such instances

222

DISEASES OF THE BRAIN.

have been under my own charge, and post-mortem examina-
tion has verified the existence of the evidences of meningitis.
This stage lasts from a few days to two weeks.

3. Stage or Period of Collapse. — The beginning of
this stage is marked by the occurrence of somnolence,
which often shows a tendency to pass into coma, and by a
subsidence of the delirium and muscular agitation. There
are times, however, during which the stupor remits in pro-
fundity, and the patient appears to be somewhat conscious
of his condition, but these periods only occur in the first part
of the third stage. Ere long the coma becomes constant.

Paralysis then supervenes and is first manifested in the
ocular or facial muscles. Thus from paralysis of one of the
muscles of the eyeball strabismus ensues, or the upper eyelid
may drop from paralysis of the levator palpebrae superioris.
The pupils dilate and become insensible to light, and the
mouth is drawn to one side from implication of the muscles
of the face. Before long the contractions of the limbs relax,
and paralysis takes place. The sphincters of the bladder
and rectum also lose their power, and the urine and faeces
escape involuntarily. The pulse becomes slow and irregular,
but the temperature, as Jaccoud has shown, and as I have
lately verified in several instances, does not fall. The insen-
sibility becomes more and more profound, and the patient
dies in a state of coma, sometimes from asphyxia produced
by paralysis of the respiratory muscles, but generally from
the gradual engorgement of the lungs.

Such is the ordinary course of an attack of simple acute
meningitis occurring in a young and healthy person. But
there are modifications often met with which require consid-
eration. Of these, epidemic cerebro-spinal meningitis is.
scarcely to be considered a disease of the nervous system,
and tubercular meningitis will be discussed under a sepa-
rate head, but the dififerences due to acute rheumatism and
old age may very properly be noticed in the present connec-
tion.

ACUTE CEREBRAL MENINGITIS. 223
CEKEBRAL RHEUMATISM.

By this term is signified the inflammatory condition in-
duced in the membranes of the brain by an attack of acute
articular rheumatism. The relation has been recognized
from the very earliest period, but, though alluded to by Flint
and other American writers, does not seem to have attracted
marked attention in this country. My own experience, how-
ever, satisfies me that meningitis of a distinct form is often
caused by rheumatism.

The membranes of the brain may become afi*ected during
the second week of an attack of acute rheumatism. The
swollen and painful joints become less swollen and less pain-
ful, and the patient may be convulsed, or, what is more com-
mon, exhibits choreiform movements in the limbs.

The delirium, which is generally present, is similar to
that met with in alcoholism. There are the same trembling
of the limbs and tremulousness of the lips.

A marked point of difierence between rheumatic and
simple meningitis consists in the entire absence in the first-
named of cephalalgia and vomiting, but it is frequently
characterized by the presence of severe pain in the back,
which may extend as high as the occiput. This was a promi-
nent feature in more than half the cases that have been un-
der my observation. The subsequent cause of rheumatic
meningitis does not difier from that of the simple form of
the disease. Coma and collapse ensue, with a general re-
mission of the violence of the symptoms. Death, however,
generally ensues, and in the way already described.

SENILE MENINGITIS.

In old persons the symptoms of acute meningitis are
rarely so pronounced as in individuals of middle age. The
afiection comes on more gradually, and may have made con-
siderable progress before its existence is suspected. There
is little or no pain, no fever, and no gastric or intestinal de-
rangement. The mental symptoms are very similar to those

224

DISEASES OF THE BRAIN.

due to softening. The patient lias imperfect articulation,
his memory is impaired, and he does things which show
that he is not in his right mind. The delirium is of the low
muttering kind, and there is a tendency to coma even in
the first stage. There is a more or less general paresis in
all the limbs, and subsultus is commonly present. Death
is usually due to pulmonary engorgement.

Causes. — Among the predisposing causes of acute cere-
bral meningitis, age is first to be considered, Guersant *
asserts that the period of life between sixteen and forty-five
is that during which acute meningitis is most liable to oc-
cur, not including children, who are far more prone to the
disease than adults. Eilliet and Barthez ' have, however,
shown that very young infants are not so subject to simple
acute meningitis as children of from five to eleven years
of age. The very opposite opinion is expressed by Drs.
Meigs and Pepper.'

Nine cases of acute simple meningitis have come under
my observation. Of these, all were between the ages of
thirty and forty.

Men are more subject to it than women. Of my cases,
seven were males and two females. Parent-Duchatelet and
Martinet,* however, think women are more predisposed to
the afiection than men.

Temperature, either very high or very low, predisposes
to acute meningitis. Five of the cases under my care oc-
curred in summer and four in winter.

Certain professions and habitudes appear to favor the
occurrence of the disease. Among the former are all those
which require the head to be exposed to strong and direct
heat ; among the latter are excessive intellectual exertion,

' Art. Meningite, in Dictionnaire de Medecine, Paris, 1839

* Traite des Maladies des Enfants, Paris, 1853.

3 A Practical Treatise on the Diseases of Children, Philadelphia, 1870, p.
464.

* Recherches sur I'lnflammation de rArachnoide, Paris, 1821.

ACUTE CEREBRAL MENINGITIS.

225

and abuse of alcoholic liquors. Tertiary syphilis, gout, and
rheumatism, are likewise predisponents.

Of exciting causes, injuries of the head from falls or
blows of different kinds stand first. Next is exposure to the
direct rays of the sun, or other source of great heat, and
then recession of an exanthematous affection, such as scar-
latina, measles, or erysipelas, and the irritation of dentition,
or intestinal worms.

Diagnosis. — Acute meningitis may be confounded with
partial or circumscribed encephalitis, but the distinction is
made by considering that in the latter the headache is less
severe, the delirium less marked, and the convulsions and
contractions weaker. Moreover, the febrile excitement is
much greater in acute meningitis than in partial encephali-
tis, and the whole disease more pronounced.

The meningitis of the aged bears a considerable degree
of resemblance to cerebral softening ; but the fact that the
first-named affection is more rapid in its progress, and is not
preceded by symptoms due to other morbid conditions, will
generally enable the practitioner to make a correct diag-
nosis.

From delirium tremens it may be distinguished by the
history of the case, by the greater tendency to insomnia ex-
hibited in alcoholism, and by the general character of the
delirium. The febrile excitement of acute meningitis, the
pain in the head, the heat of the skin, the absence of clammy
perspiration, and the increased temperature, as shown by
the thermometer, are conclusive diagnostic marks.

From typhoid fever meningitis is diagnosticated by the
existence in the former of meteorism, abdominal tenderness,
and petechige, by the facts that the headache and febrile ex-
citement are less, and that diarrhoea is present and vomiting
is not.

Prognosis. — This is always grave. Occasionally death
takes place in a few hours, and generally before the tenth
day. "When the disease is prolonged beyond this latter pe-
15

226 DISEASES OF THE BRAIN

riod, the prognosis becomes more favorable. The occur-
rence of strabismus or other paralytic affection lessens the
hope of a favorable termination. Prof. Flint, however, has
cited two cases occurring in the hospital practice of himself
and Dr. Thomas, in which there were strabismus, hemiple-
gia, and coma, both of which recovered. He also cites
another case in which there was strabismus, and in which
recovery took place. Hiccough is an unfavorable event.

Of the nine cases observed by myself seven died. In all
of these fatal cases there was strabismus. In the two cases
which recovered there was no squinting. The deaths in the
fatal cases all occurred before the tenth day, and two took
place before the end of the third day.

Korbid Anatomy. — If death occurs during the second stage
of the disease, the most marked appearance found in the
membranes is redness from increased hypersemia. If, how-
ever, it is delayed till the third stage, effusion of serum is
the prominent feature. In a case of which I made a post-
mortem examination last summer, and which was caused by
the great heat of the season, there was an extensive collec-
tion of bloody serum in the cavity of the arachnoid, and the
pia mater was so adherent as to bring with it a layer of the
gray matter of the brain as it was stripped off.

The fluid may consist solely of pus, or this may be
mingled with serum in all proportions. The pus, with the
fibrine of the exuded serum, forms thin plates of membrani-
form texture, which are scattered over the surface of the in-
flamed region or may entirely cover it.

If death has taken place late in the course of the disease,
evidences of the implication of the cerebral substance will
generally be discerned. These consist in the gray substance
becoming of a pinkish color, and the white, when cut, show-
ing numerous puncta vasculosa. The ventricles rarely con-
tain any considerable amount of fluid, and are often entirely
empty. The latter was the case in the instance above men-
tioned.

ACUTE CEKEBRAL MENINGITIS.

227

Pathology. — The symptoms of the first and second stages
are due to congestion ; those of the third mainly to efi'usion
and consequent pressure.

An important question connected with the pathology re-
lates to the determination, from the symptoms, what part of
the brain is the seat of the lesion. The upper convex por-
tion of the hemispheres is intimately related to the purely
intellectual functions of the brain, while the under surface,
or base, is connected with the motility of various parts of
the body. Thus, if the inflammation be strictly limited to
the upper surface of the brain, the predominant symptoms
are those involving intellectuality, and consequently there
ia delirium, marked by incoherence of ideas and irrational-
ity of language. If, on the contrary, the base of the brain
alone is alfected, the chief manifestations of disease are seen
in the muscular system, and there are contractions, spasms,
convulsions, and paralysis. When the morbid action ex-
tends to both regions, there is a combination of these phe-
nomena.

But, as Jaccoud' states, there are some stubborn facts
which stand in the way of the unreserved acceptance of the
law laid down, for it occasionally happens that the symp-
toms are not in direct relation with the seat of the lesion.
Thus in the case, the post-mortem examination of which I
have referred to, there had been spasms and paralysis, yet
the convex surface of the right hemisphere was alone in-
volved, and that to an extent not exceeding a third the size
of the hand. Jaccoud explains such cases by attributing to
the cerebral symptoms a double origin ; one set being due
directly to the part affected, the other resulting from sec-
ondary reflex excitation. The explanation seems logical.

Another fact should also be taken into consideration.
In acute cerebral meningitis there is very frequently a large
effusion of serum or an extensive formation of pus. If
either be collected on the upper convex surface of either

' Op. cit., p. 212.

228

DISEASES OF THE BRAIN.

hemisphere, the pressure exerted through the intervening
brain-substance upon the motor tract at the base must pro-
duce more or less derangement of motility on the opposite
side of the body.

Guyot," who has given very careful study to the localiza-
tion of the lesion from a consideration of the symptoms, de-
clares that it is possible to define the seat very accurately,
but his manner of looking at the subject places it in alto-
gether a different position from that which Jaccoud gives
it. Thus, tracing the fibres of the motor tract through the
white substance to the convex surface of the hemispheres,
he associates lesion of this region, not only with disturbances
of ideation, but with derangement of motor functions. In
this view he is supported by the experience of MM. Parent-
Duchatelet and Martinet," who state that in eight subjects
who had exhibited hemiplegia in the beginning of paralysis
on one side of the body, they had discovered, on post-mortem
examination, efiusion on the convexity of the opposite hemi-
sphere.

When, however, the lesion is limited to the base, the
functions of the hemispheres will not be affected, except
upon the principle of reflex irritation or of the transmission
of pressure. It is evident, however, that further researches,
based upon post-mortem examinations, are necessary to the
satisfactory solution of the interesting questions involved.

Treatment. — To afford any chance of a favorable result,
the treatment should be energetic from the first.

General bloodletting may be practised with advantage
in subjects of good constitution and of the middle period of
life. As much as twelve or sixteen ounces may be taken
from the arm if the pulse is hard, the cephalalgia intense, or
the delirium furious. Leeches applied behind the ears or to
the inside of the nostrils are more generally of advantage.
The same may be said of cups to the nucha.

> Du Rapport des Symptoms avec les Lesions dans la M6nmgite. These de
Paris, 1859. * « Op. cit.

ACUTE CEREBRAL MENINGITIS.

229

The hair should be cut off short, and ice kept constantly
applied to the scalp during the first and second stages. It
is better than the cold douche, for the reason that it is al-
most impossible to continue the latter without intermissions,
during which the head again becomes hot. Compresses
wrung out of cold water will not answer ; thej soon get heat-
ed, and act as poultices. Irrigation, by a small stream of
ice-water falling from a vessel placed above the head of the
patient, is a useful means of applying cold, but is often in-
convenient.

Purgatives are generally advantageous and should be ef-
fective. Nothing is better than croton oil, although calomel
and podophyllin, grs. x with grs. ij, make a good combina-
tion for the purpose.

My experience has satisfied me of the good effects of mer-
curialization. I have administered calomel in doses of a
grain every two hours until the breath became fetid, and
I am sure the effect has been beneficial.

The iodide of potassium is well spoken of by Dr. Flint,'
who says he has witnessed the good effects of the drug in
several cases. Dr. F. R. Lyman ^ has reported two cases in
which it formed a prominent feature of the treatment, and
in which recovery took place.

"Within late years in the few cases of acute cerebral men-
ingitis that have been under my charge, I have found the
greatest benefit from the bromide of potassium, and the
three cases that recovered were instances in which it was ad-
ministered in large doses. The theory upon which its em-
ployment is based has already been fully considered in the
chapter on cerebral congestion. It should be administered
in doses of at least thirty grains three or four times a day,
from the very beginning of the affection to the end of the
second stage or the appearance of coma, should this symp-
tom supervene.

The head should be kept well elevated, the chamber cool,

' Op. cit., p. 601. ' American Medical Times, 1862, p. 334.

230

DISEASES OF THE BRAIN.

and well ventilated, the light in a great measure excluded,
and the utmost quiet enjoined.

The food, without being stimulating, should be nutri-
tious. Nothing is superior to strong beef-tea, made either
from fresh beef or from some one of the extracts in the mar-
ket.

In the third stage the treatment should be almost the
reverse of that indicated as proper for the first and second
stages. The mercury, iodide of potassium, bromide of potas-
sium, ice to the head, and purgatives should be omitted, and
attention should be given to the maintenance of the strength.
To this end brandy, whiskey, or other alcoholic liquor, should
be administered in such quantities as the occasion seems to
require. It often happens in this stage that the delirium
and excessive motility return. It must be remembered
that this is not from any renewal of morbid processes with-
in the cranium, but is entirely due to debility. At the mo-
ment of writing this, a young lady of this city is under my
charge for acute cerebral meningitis, whom I did not see till
the third stage was well advanced, and who for several days
previously had exhibited a return of the delirium, for which
depletive measures and hydrate of chloral had been employed.
The free administration of brandy, champagne, and beef-tea
soon dissipated the symptoms of relapse, and she bids fair to
recover.

Blisters may be used in this stage with advantage. They
are best applied between the shoulders, and should be six or
eight inches square.

In the rheumatic form of the disease little special treat-
ment is necessary. It is, perhaps, advisable to endeavor, by
means of blisters or other revulsives, to bring back the dis-
ease to the joints.

In the acute meningitis of the aged, active depletive treat-
ment is not so generally admissible, and if apparently indi-
cated should be carried out cautiously. It may even be
proper to treat some cases with stimulants from the very first.

CHAPTER IX.

CHRONIC CEREBRAL MENINGITIS.

Although sometimes a consequence of an acute attack,
chronic cerebral meningitis is more generally an original
affection.

Symptoms. — The symptoms of chronic cerebral meningi-
tis are very similar to those indicative of softening. These
are headache, somnolency, trembling, defective articulation,
feebleness of the limbs, paralysis of the bladder, or of the
sphincters of the bladder and rectum, producing involuntary
discharges of urine and faeces, weakness of the memory, and
general enfeeblement of all the mental faculties. The prog-
ress of the disease is slow, and therefore these symptoms may
extend over several months or even years. They may, how-
ever, at any time be intensified by the development of a more
acute form of inflammation.

Chronic cerebral meningitis, when due, as it may be, to
syphilitic infection, runs its course more rapidly, and the
symptoms are more decided. The third nerve is particu-
larly liable to be involved, and hence there are ptosis, stra-
bismus, double vision, and alterations in the normal size and
motility of the pupils. The facial may likewise be involved,
causing paralysis or spasms, and the fifth, giving rise to neu-
ralgia, anaesthesia, or destruction of the eyeball from de-
ranged nutrition.

Under the name of "general paralysis" Calmeil* de-
scribed an affection which is not uncommon among the in-

' De la Paralysie Consider^e chez les Ali^nes, Paris, 1826.

232

DISEASES OF THE BRAIN.

sane, and which may be developed in persons not the sub-
jects of mental alienation. A prominent morbid condition
in such cases is frequently chronic meningitis, but the pecu-
liarities of general paralysis are sufficiently well marked to
require for it a separate consideration.

Causes. — The etiology of chronic cerebral meningitis fre-
quently cannot be ascertained. It is sometimes the result of
an acute attack, and, when it arises spontaneously, may be
due to the excessive use of alcoholic liquors, or to syphilitic
infection. Beyond this our knowledge does not extend.

Diagnosis. — This is often impossible to be made out, with
even a moderate degree of exactness, and is always difficult.
The affection may be confounded with cerebral softening,
and the most careful study will in many cases fail in mak-
ing the discrimination between them. The difficulty is fre-
quently heightened by the fact that the two diseases co-
exist.

Prognosis. — This is almost invariably unfavorable, unless
a syphilitic origin can be discovered, in which latter case the
prospect of recovery is very materially enhanced.

Morbid Anatomy and Pathology. — The essential feature in
the morbid anatomy of chronic cerebral meningitis is a new
formation of connective tissue, by which the membranes
adhere to each other and to the brain, and by which they
are rendered opaque and thicker than "normal.

In addition there may be deposits of exudation on the
convexity or base of the brain, which, though intimately
connected with the alterations of the membranes, are yet
distinct from them.

The seat of the lesion may probably be determined with
more exactness than in the acute form of the disease, for the
reasons that the morbid process is extended over a longer
period, and that the symptoms accordingly are more discrete,
and that they are not marked by delirium and fever. The
same principles are applicable to the inquiry, as have already
been laid down.

CHRONIC CEREBRAL MENINGITIS.

233

Treatment. — The very active treatment adopted by some
practitioners never leads to favorable results, and only seems
to annoy or exhaust the patient. The syphilitic variety of
the aflfection may generally be successfully combated by
the iodide of potassium and mercury ; but the simple, un-
complicated form is quite unamenable to therapeutic meas-
ures. For the former there is no better combination than
that of bichloride of mercury, with iodide of potassium in
solution, so that the one-sixteenth of a grain of the bichlo-
ride is taken, with from ten to thirty of the iodide, three
times a day. Even if the disease have not a syphilitic ori-
gin, this is probably the best treatment which can at pres-
ent be suggested. In either form antiphlogistic measures
are contraindicated. On the contrary, wine and highly-nu-
tritious food are frequently productive of amelioration.

CHAPTER X.

TUBERCULAB CEBEBBAL MENINGITIS.

Inflammation of the membranes of the brain, attended
with or due to a deposit of miliary tubercles, was for many
years considered as a disease peculiar to infancy, and was
known as acute hydrocephalus before its morbid anatomy
and pathology were clearly comprehended. It is now well
understood to be an affection to which adults are liable.

By some authors, especially Robin and Bouchut, it is
regarded as not being tubercular in character. It has hence
occasionally been termed granular meningitis. Although
mentioned by the ancient medical writers, no clear and
systematic description of tubercular meningitis was given
till Whyte * published his essay on the subject of dropsy of
the brain. Since that time it has received the attention of
many writers in this country. Great Britain, France, and
Germany.

Symptoms. — Whyte defined three periods of the disease,
which he marked by the state of the pulse. I think the
symptoms may be properly arranged in four stages : 1. The
prodromatic stage ; 2. The stage of excitement ; 3. The
stage of depression ; and 4. The stage of recurrence.

1. The Pkodeomatic Stage. — This period may be alto-
gether wanting, or may be so slightly manifested as not to
be noticed. Generally, however, it is well marked.

1 Observations on the most Frequent Form of the Hydrocephalus Intemus,
viz., Dropsy of the Ventricles of the Brain. Works of Robert Whyte, edited
by his son. Edinburgh, 1768, p. 725.

TUBERCULAR CEREBRAL MENINGITIS.

235

If the child be sufficiently advanced in years, a change
of disposition is among the first symptoms perceived. Thus
the temper becomes irritable, caresses are disregarded, and
dislike is shown for those amusements which formerly gave
pleasure. At the same time the appetite disappears, and
the child loses flesh rapidly. This latter is not noticed about
the face, but is mainly confined to the abdomen and limbs.
The bowels are generally obstinately constipated, but occa-
sionally there is diarrhoea. Headache is not often com-
plained of ; neither is vomiting a common symptom of this
period. Fever is not continuous, although it is generally
present at irregular times of the day.

The prodromatic stage may last only a few days, or may
be prolonged for two or three months.

2. The Stage of Excitement. — This period is ushered
in by obstinate vomiting, which is present in many cases,
even though no food be taken. Intense pain in the head is
a coincident symptom, and is so severe that the child puts
his hands to his head and cries out or awakes screaming-.
Convulsions may also occur. They do not differ in general
appearance from the ordinary epileptic paroxysms, and may
be repeated several times.

Very early in this stage the fever becomes more persist-
ent than in the first stage, although it may still be irregular.
The pulse, however, is not hard and resisting, as in other
inflammatory affections, hut is soft and compressible.

Trousseau * has called attention to a condition of the
skin present in tubercular meningitis, which he at first re-
garded as peculiar to this disease, but which subsequent in-
vestigation showed was likewise found in simple meningitis,
in typhoid fever, and some other affections. If the finger-
nail be passed lightly over the surface of the abdomen or
the thorax so as to trace a series of lines, in about thirty
seconds the skin becomes red — the color being at first dif-
fused, but very soon the lines made by the nail are indicated

* Op. cit., Le9on Iv., Fi^vrc Cerebrale.

236

DISEASES OF THE BRAIN.

by a still redder color, wliieli persists a long time. Trous-
seau calls this appearance tlie " cerebral stain " {tache cere-
hrale). The phenomenon he attributes to a profound modi-
fication in the vascularization of the skin ; and although it
is not to be regarded as absolutely pathognomonic, it is a
sign of very great importance.

The intellectual faculties are not yet affected to any
considerable extent, but the changes of character and dispo-
sition, and indifference to things which formerly excited in-
terest, are still well marked.

The physical strength, though lessened, is still not yet so
far reduced as to oblige the patient to remain in bed.

The tongue is usually coated and red at the edges, the
appetite diminished, and the bowels are obstinately consti-
pated.

The temperature of the body is elevated, but not to an
extreme degree ; the thermometer indicating from 101° to
103° F. Sometimes there are distinct remissions in the vio-
lence of all the symptoms, but the disease nevertheless goes
on to its full development. The transmission from the
second to the third stage is often marked by an ameliora-
tion which may last several days.

From what has been said, it will be seen that the charac-
teristic phonomena of this stage are headache and vomiting.
Its duration varies from seven to fourteen days.

3. Stage of Depression. — The pulse, which in the
previous stage was sometimes as high as 140, and some-
times as low as 80, now becomes less rapid than is nor-
mal, and may even fall below 50. At the same time the
beat is quick, but the interval between the pulsations is at
times so great that the observer is, as Dance ' says, fearful
that the action of the heart has stopped. The interval be-
tween the pulsations is often irregular, and this may be
regarded as a sign of unfavorable import.

In young infants there is a reduction in the temperature

' Memoire sur I'hydrocephale. Archives Gen. de Med., 1830.

TUBERCULAR CEREBRAL MENINGITIS.

237

of the body below the normal standard, wliicli lasts through-
out the whole of this period. Roger regarded this reduc-
tion, preceded as it is by a higher temperature, and followed
during the succeeding stage by another elevation, as pathog-
nomonic of tubercular meningitis.

The continued excitement of the previous stage is re-
placed in this by a strong tendency to somnolence, which
alternates with a rather quiet delirium. The patient lies on
his back, with the eyes fixed, but yet not looking at any
object with attention. Events transpiring around him no
longer attract notice, and, though when addressed in a loud
tone he may turn his gaze toward the speaker, it is very
evident that the words convey no idea to his mind.

The fingers are kept in almost continual motion, picking
up threads and other small objects from the bedclothes, and
occasionally clutching at imaginary things. Again, the fin-
gers are alternately opened and shut without any real or
apparent motive, and again the head is turned restlessly
from side to side of the pillow. Convulsions are very gen-
erally present from time to time during this stage, and may
be so frequently repeated as to leave scarcely any interval
between the seizures. Even if the attacks do not involve
the body generally, the eyes scarcely ever escape ; there be-
ing strabismus, convulsive movements of the pupils, and
constant motions of the eyeballs. The facial muscles are
likewise often afiected.

In the intervals of wakefulness, the cephalalgia contin-
ues, and causes the peculiar scream which is so character-
istic as to have received the name of the " hydrocephalic
cry." It is a sound such as might be produced by mingled
emotions of terror and grief. Although probably excited
by the pain, it is more or less automatic, and is not exactly
such a cry as would be produced by unmixed physical suffer-
ing. It is accompanied, however, by that contraction of the
muscles of the face indicative of suffering.

The paleness of the countenance continues, but at times

238

DISEASES OF THE BRAIN.

there is a sudden redness, wMcli disappears as rapidly as it
comes.

The conjiinctivse are generally injected, and photophobia
is present. M. Bouchut,' who has given great attention to
the subject of ophthalmoscopy in diseases of the nervous sys-
tem, finds peripapillary congestion, dilatation of the retinal
vessels, and deformation of the papillse.

There is often a general hypersesthesia of the skin, for
which, however, anaesthesia may be substituted. When this
latter is the case the conjunctivae participate, and inflamma-
tion results.

The limbs are weak, and, should the patient attempt to
walk, the gait is staggering. The speech is hesitating, is
rarely indulged in except in response to questions, and then
with the least possible expenditure of words.

The vomiting, which formed so prominent a symptom of
the previous stage, has ceased, but the constipation still per-
sists.

The respiration is irregular, sometimes being rapid and
sometimes slow. Occasionally there are deep sighs, followed
by numerous quick inspirations, and again the respiratory
movements may be so slight as scarcely to be perceived.
This variation from the normal action, as well as the irregu-
larity of the heart's movements, is due to the implication of
the pneumogastric nerves at their origins.

This stage may last for from two or three days to two
weeks.

4. Stage of Recurrence. — The characteristic pheno-
mena of this stage are the return of the fever and the
increase in the violence of the symptoms indicative of
cerebral disturbance. Before its onset there may be a pe-
riod of nearly complete intermission, so that the impression
may be formed that recovery is taking place. This apparent
cessation of the morbid action, however, only serves, with

' Du Diagnostic des Maladies du Syst^me Nerveux par I'Ophthalmoscopie,
Paris, 1866, p. 45, et seq. Plates iv., v., yi., vii., viii., ix., and xi., of the Atlas.

TUBERCULAR CEREBRAL MENINGITIS.

239

the experienced observer, to make the reappearance of the
symptoms more striking.

Convulsions are more frequent and violent than in the
previous stage, and tonic contractions of the limbs are not
uncommon. These contractions are more generally met
with in the muscles of the neck and upper extremities, and
vary from time to time in their intensity. The head is thus
thrown backward, and, as the morbid action frequently ex-
tends to the muscles of the back, an appearance in the pa-
tient not unlike that present in tetanus is produced.

Paralysis eventually supervenes. At first this is incom-
plete, affecting only a single limb or the muscles of the face,
but it extends, and both limbs on one side or an arm and a
leg of opposite sides become involved. Voluntary power is
lost, but reflex movements can be excited by pinching or
tickling.

The delirium acquires increased intensity, and alternates
with the somnolence, which likewise becomes more profound,
and which gradually masks all the other symptoms, till at
last the coma is persistent and general, and spinal sensibility
is lost.

Before death the pulse rises in frequency, a cold sweat
makes its appearance, and the patient dies either by a slow
process of asphyxia, or in convulsions.

The fact that tubercular meningitis is not confined to in-
fants is now generally admitted. Dance * was the first to
recognize its occurrence in adults, and Gerhard," of Philadel-
phia, a few years subsequently reported several cases. Le-
dibuder ' also pointed out the analogy between the tubercu-
lar meningitis of infants and that of adults, and still later
Yalleix* gave the weight of his authority to the same
effect.

' Op. cit. * American Journal of the Medical Sciences, 1834.

2 Essai sur 1' Affection Tuberculeuse Aigue de la pie-mere, Paris, 1837.
* De la Meningite Tuberculeuse chez I'adult. Archives Gen4rale de Mede-
cine, 1838.

240

DISEASES OF THE BRAIN.

So far as the symptoms are concerned, I have never
been able to perceive any essential points of difference
between the tubercular meningitis of children and that of
adults.

The affection is, of course, modified, as are all other dis-
eases, by the age of the patient, but, when allowance is made
for this factor, the morbid process is one and the same in
character. In adults, however, it generally supervenes in
the course of tuberculosis of the lungs, whereas in infants it
is ordinarily a primary manifestation of the tubercular diath-
esis.

Causes. — Tubercular meningitis is an expression of a gen-
eral state of the system. To enter at length into the ques-
tion of its etiology would necessarily involve a discussion of
the cause of the diathesis to which it is essentially due.
Nevertheless, there are a number of determining causes that
may be appropriately considered. Age is an important fac-
tor in determining the accession of tubercular meningitis.
It is rare during the first year of infancy, but is more com-
mon during the period extending from the second to the
seventh year than any other time of life. From eight to ten
it is much less frequent, and from ten to fifteen is rarely
seen.

In adults it is most common between the ages of seven-
teen and thirty. From thirty to forty it is rare, and after
forty is scarcely ever met with.

Males are more frequently the subjects of tubercular
meningitis than females, and this holds good for all ages
of life.

The season of the year appears to exercise no influence.

As to many other exciting causes alleged by authors,
such as blows, emotional excitement, and previous diseases,
nothing very definite is known. The same cannot, however,
be said of the morbific influence of bad air, insufficient food,
improper clothing, neglect of cleanliness, and a disregard for
other sanitary requirements.

TUBERCULAR CEREBRAL MENINGITIS.

241

Diagnosis. — Tubercular meningitis is liable to be eon-
founded with several other affections, and can sometimes
only be distinguished with difficulty.

From simple meningitis it may be diagnosticated by the
facts thai the onset of the former is sudden, while the latter
is insidious in its approach, and slow in the development of
its symptoms ; the one goes on steadily through its course,
the other halts and remits ; in the one the temperature of
the body rises several degrees, in the other the elevation is
scarcely ever more than two degrees ; in the one there is no
hereditary tendency, while in the other inquiry will usually
reveal the existence of hereditary tubercular predisposition.

The mental symptoms show a marked difference. In
simple meningitis the delirium is often furious, and is always
very active ; in the tubercular form of the disease the de-
lirium is quiet, and alternates with stupor.

In typhoid fever there may be vomiting and headache,
but the bowels are not constipated, and there is tenderness
over the right hypogastric region. Moreover, the epistaxis,
the eruption, and the swelling of the spleen, which occur
in typhoid fever, will aid in making the diagnosis more cer-
tain.

"Worms in the alimentary canal may give rise to a set of
symptoms very similar to those which form the prodromata
of tubercular meningitis. As Jaccoud observes, therefore,
it is well, whenever a child exhibits these symptoms, to ad-
minister one or two doses of a strong vermifuge.

A peculiar affection, to which young infants are liable,
may ' be mistaken for tubercular meningitis. It was first
described by Dr. Gooch,' but derived its name — "hydroceph-
aloid disease" — from Dr. Marshall Hall. I have already
alluded to this disorder under the head of cerebral anaemia.
In it the child is irritable, restless, starting at every noise,
moving in sleep, and often waking screaming. Yomiting is

• On Some Symptoms in Children erroneously attributed to Congestion of the
Brain. Gooch's Essays, New Sydenham Society, 1859, p. 179.
16

242

DISEASES OF THE BRAIN.

frequently present, but tlie bowels are loose. The whole
appearance of the child betokens exhaustion, and, if due
care be not taken, death may ensue. The absence of con-
stipation, the history of the case, and the depressed state of
the fontanelle, if this be yet open, will suffice to render the
diagnosis clear.

Trousseau considers the irregularity of the respiration
the most important sign indicating the presence of tuber-
cular meningitis. "In no other disease," he says, "will
you meet with this singular anomaly. You will not
observe this unequal and irregular respiration either in
the essential convulsions of infancy or in typhoid fever.
I have reason, then, for insisting on the importance of the
symptom."

Prognosis. — There is not much to say under this head.
The ordinary termination of the disease is death. I have
never seen a case recover ; and, though instances with a
favorable result have been reported, I am disposed to think
the diagnosis of such has been erroneous. Drs. Meigs and
Pepper,* of thirty-one cases, had no recovery, though they
report a case of tuberculosis of the meninges — not tuber-
cular meningitis — in which recovery appears to have taken
place, though the child died a year or two afterward with
dysentery.

It seems contrary to reason to expect a radical cure in a
disease in which the cause cannot be removed. Do what
we will, the tubercular deposit remains ; and, as Jaccoud
remarks, the reported cases of recovery were rather in-
stances of a long remission in the intensity of the symp-
toms.

Morbid Anatomy and Pathology. — A question arises at the
outset of an inquiry relative to the morbid anatomy of tu-
bercular meningitis, which refers to the essential character
of the disease ; and that is, whether the gray semi-trans-

' A Practical Treatise on the Diseases of Children. Philadelphia, 1870, p.
452.

TUBERCULAR CEREBRAL MENINGITIS.

243

parent granulations met with on post-mortem examination
are tubercles, or whether they are an entirely distinct
morbid product ? Yalleix, Rilliet and Barthez, Barrier,
Grissole, Meigs and Pepper, and others, regard them as tu-
bercles. GrissoU expresses himself clearly on this point.
" We have no doubt," he says, " that these granulations are
tubercles in a rudimentary state ; for we have many times,
in the same subject, followed the morbid product in its dif-
ferent phases of evolution from the amorphous condition to
the fully-developed tubercle."

On the other hand, Bouchut, basing his conclusions
mainly on the microscoj)ical observations of Robin, is of
the opinion that the granulations are formed : 1. Of fibro-
plastic elements, consisting of free nuclei and fusiform cells,
and ovoid cells. The nuclei are ovoid or spherical, and gen-
erally very small, not exceeding 0,008 to 0.009 in, in diam-
eter. 2. Of a great quantity of granular amorphous homo-
geneous matter, which keeps the other elements strongly
united. 3. Of a few vessels and fibres of connective tissue.
Among all these elements the tubercular corpuscles of mi-
crographers are not to be found ; and, therefore, the disease
cannot be regarded as tubercular in character. M. Empis '
also contends that the microscopical analysis shows that the
gray granulations are entirely distinct from tubercle. On
the other hand, it is alleged — and I am disposed to think with
force — that the most which the investigations of M. Robin
and others in accord with him show, is, that there is no
special characteristic of tubercle which will enable us to
declare with certainty that it is present, and that it does
not possess a structure which is the same in all stages of its
development. The collateral evidence goes very far to sup-
port the view that the granulations are tubercular in char-
acter.

The question which also arises, as to whether the inflam-
mation precedes the tubercular deposit, or vice vei*sa, is gen-

» Trait6 de la Granulie. Paris, 1865.

DISEASES OF THE BRAIN.

erally decided in favor of the prior appearance of the tuber-
cles. The granulations are met with in the course of the
vessels of the pia mater. This membrane is always more
or less inflamed, and is thickened by the infiltration of
sanguinous, serous, plastic, or purulent exudations. The
granular or tubercular matter is likewise deposited at the
base of the brain, and in this position is doubtless the cause
of the derangements of motility which constitute so promi-
nent a feature of the disease.

The tissue of the brain is not generally much involved,
although on section the red points, indicative of the situa-
tion of blood-vessels, are very much increased in number.
Occasionally there are small extravasations of blood found
in the gray substance.

The ventricles are distended by serum, and this is some-
times so great in quantity as to cause the rupture of the
septum lucidum. The liquid is either clear and limpid,
milky from the presence of pns-globules, or bloody from
containing red corpuscles.

The morbid anatomy of the lungs and other organs, al-
though interesting in the present connection, need not be
dwelt upon ; suffice it to say that tubercular deposits are
always met with in some one or more of the viscera and
especially in the lungs.

Treatment. — In regard to a disease so uniformly fatal as
tubercular meningitis, there is not much to say. The prin-
cipal advice I have to give is, to refrain from blisters, anti-
monial ointment, leeches, and drastic purgatives, which
have no other effect than to shorten the life of the patient,
and to make his existence still more intolerable than it is
made by disease. Iodide of potassium does less harm, but
I have never known it do any good. Niemeyer, however,
recommends it, and many will doubtless continue to employ
it on his authority.

When we have any reason to suspect an hereditary ten-
dency to tubercular meningitis, prophylactic measures may

TUBERCULAR CEREBRAL MENINGITIS.

245

be used with hope of success. These consist in providing
for pure air, ample clothing, nutritious food, and in the ad-
ministration of cod-liver oil, iron, iodine, and quinine. A
climate not subject to sudden vicissitudes, and of such a
character as regards warmth and dryness that the patient
can spend a great portion of the day in the open air, is also
a matter of prime importance.

CHAPTER XI.

SUPPURATIVE ENCEPHALITIS OR CEREBRITIS.

Suppurative inflammation of the brain is a verj rare
affection uncomplicated with meningitis. In this latter
connection it has already been sufficiently considered. In
the present chapter, therefore, I shall discuss it solely as an
independent lesion, and mainly in reference to the subse-
quent formation of abscess.

Symptoms. — The symptoms of suppurative inflammation
of the brain vary according to the seat of the lesion, and are
rarely of such a character as to enable us to say, with any
great degree of certainty, that we have a case of uncompli-
cated encephalitis before us. ^Nevertheless, certain phe-
nomena have been recognized, and, after death, the evi-
dences of inflammation of the brain have been discovered.
But these symptoms are, many of them, met with in other
cerebral disorders, and therefore cannot be regarded as pa-
thognomonic. It is difficult, if not impossible, to arrange
them in stages ; and therefore, after the prodromata, I shall
consider the phenomena of acute encephalitis in accordance
with their relation to the several functions of the organism
liable to be afiected.

The premonitory symptoms are similar to those of cere-
bral congestion, and doubtless depend upon a like patho-
logical condition. Thus there are vertigo, pain in the head,
noises in the ears, troubles of vision, numbness, and difficul-
ties of speech. They never, however, last as long as they
do in simple congestion.

SUPPURATIVE ENCEPHALITIS OR CEREBRITIS. 247

Sometimes the first-observed symptom of approaching
encephalitis is an epileptiform convulsion.

In the fully-established disease the phenomena are very
decided, but at the same time have no necessary or con-
stant relation with the pathology, as similar symptoms are
met "with in other very different affections.

Disorders of Sensibility. — At first, there is generally
hypersesthesia ; subsequently, anaesthesia. Headache is a
common symptom, as it is in so many other cerebral diseases.
There is no particular location of the pain — sometimes the
frontal region, at others the occipital, and again the vertical
or parietal regions, being its seat. It varies, likewise, as re-
gards intensity and form, and may consist of a feeling of
fulness or constriction only. It is present from the very be-
ginning of the disease, and usually continues through its
whole course.

Pains are felt in various parts of the body, are sharp and
lancinating, and often attended with cramps. Cutaneous
hypersesthesia is also occasionally met with.

In the next place, there is anaesthesia, with all its accom-
paniments of formication, numbness, and other abnormal
sensations of tlie kind, mainly affecting the face and upper
extremities. As to the special senses, the sight is almost
always deranged. There are bright flashes of light, irides-
cent appearances, and photophobia, all showing increased
irritability of the retina. The pupils are contracted, the
conjunctivae suffused, and the eyeballs are the seat of a dull,
aching pain. Subsequently, the pupils become dilated, and
vision is lost. Ophthalmoscopic examination shows, in the
early stages, papillary infiltration, with retinal congestion,
and later, papillary atrophy and granular degeneration, the
results of optic neuritis. There is also, generally, double
vision, to which allusion will be more fully made directly.

The hearing is at first very acute, and even slight noises
are more or less painful. Noises in the ears, of various
kinds, are present. As the disease advances, the hearing

248

DISEASES OF THE BRAIN.

becomes mucli impaired, and is gradually lost, in one or
both ears.

The taste and smell are rarely affected.

Disorders of Motility. — As with the sensibility, the mo-
tor organs of the body at first exhibit evidences of increased
excitability. Thus, there are twitchings of the muscles,
mainly of those of the face, and clonic or tonic spasms.
Sometimes these last for several days. Subsultus is especi-
ally noticed in the flexor tendons of the wrist.

General convulsions may take place, with or without loss
of consciousness. Frequently the action is limited to one
side of the body, or implicates one side of the face, or a
single limb. Strabismus occurs, and double vision is pro-
duced, at this stage, from spasms of one of the ocular muscles.

This period of muscular excitation corresponds very ac-
curately with the stage of augmented sensibility.

It is succeeded by a period of diminished motor j>ower.
Paralysis generally begins in a distant part of the body, and
slowly involves one side. Thus, there may at first be a dif-
ficulty in raising the toes, or in grasping things with the
fingers ; then the knee becomes weak, the flexors of the
thigh follow, and the whole limb drags. If the arm be the
first member affected, the difficulty advances from the fin-
gers to the elbow, and thence to the shoulder. Sometimes
the morbid action extends equally on both sides of the body,
and then the gait becomes weak and shuffling. The legs
are spread wide apart, so as to increase the base, and keep
the centre of gravity more easily within it. The knees are
bent, the pelvis is flexed on the thighs, and the whole body
is inclined forward. The face rarely escapes. It may be
affected on one side only, in which case there is distortion,
or there may be a gradual failure of muscular power on
both sides. The muscles connected with the eyes almost
always suffer. Ptosis is common, and external strabismus,
causing double vision, accompanies it, both being produced
by the implication of the third or motor oculi nerve.

SUPPURATIVE ENCEPHALITIS OR CEREBRITIS. 249

One side of the face sometimes becomes permanently
contracted, and thus an appearance is produced somewhat
resembling that which is caused by paralysis of the opposite
side. It may be distinguished from this latter condition,
however, by the fact that in it the eyelids are spasmodically
closed, and the side of the face much more distorted than
when there is paralysis of the opposite side. The tongue is
always, in my experience, prominently affected. The first
sign of diminished motility is the frequency with which it
is bitten, in conversation or mastication, and sometimes it
is made quite sore, on one or both sides, or at the tip, from
this cause. Then the patient discovers that long-continued
speaking causes a sensation of fatigue, at the root of the
tongue, and that a feeling as if this organ were too large for
the mouth is experienced. Then articulation becomes in-
distinct, the words are clipped or slurred over, so that at
times it is difficult for others to understand what he says.

Disorders of Intelligence. — The first indication of mental
weakness is the susceptibility experienced to the influence
of emotions. The patient will thus get uncontrollable fits
of laughing or crying from very slight causes, and some-
times from no apparent cause. These paroxysms are fre-
quently of mixed character, the patient passing from laugh-
ing to crying, and vice versa.

The memory begins to fail at a very early period, espe-
cially as regards the names of things. The enfeeblement is
by no means, however, confined to words, but facts and cir-
cumstances likewise fail to be remembered. Gradually a
condition of complete dementia ensues, and finally coma,
with or without previous or alternating delirium.

Disorders of the Functions of Organic Life. — There is
always febrile excitement in encephalitis. At first the pulse
is frequent, rising to 120, but as the disease advances it falls
till toward the close it goes below the normal standard.
It is characterized, according to Barras,* by a characteristic

* Bulletin de la Society Medicale d'^Imulation, Juin et October, 1823,

250

DISEASES OF THE BRAIN.

tremulousness {tremhlottement)^ which he compares to the
unequal vibrations of a cord moderately stretched. This
peculiarity he attributes to irregular arterial dilatation.
According to my experience, the symptom is by no means
constantly met with, and it certainly is not pathognomonic,
for the same peculiarity of pulse is found in several other
disorders. In a case, however, now under my care, in which
there is reason to suspect encephalitis and abscess, the phe-
nomenon is present in a marked degree, not only in tlie ra
dial artery but in the temporal and the angular, as it passes
between the nose and the inner angle of the orbit.

The respiration in the first stages is not materially de-
ranged, but later it becomes irregular and stertorous, and
finally asphyxia may take place.

The temperature of the body is elevated till the fever
abates, and paralysis makes its appearance. The thermome-
ter rarely, however, goes above 103° Fahr., and is generally
a degree below this point.

The digestive organs usually show more or less evidence
of derangement. Constipation is always a prominent fea-
ture, and the appetite is capricious. At times the patient
refuses to eat, at others he will cram his stomach with all
kinds of edibles. Digestion is often troublesome, and occa-
sionally dangerous from paralysis of the pharyngeal muscles.
Cases are on record in which death has occurred by the food
becoming impacted in the throat, and several cases have
come under my own notice, in which, from a like cause, a
fatal result was barel}^ prevented by the use of very ener-
getic measures.

Moreover, the secretions of the mouth are almost always
altered either in quantity or quality, or both, and the sensi-
bility of the tongue and faucial mucous membrane is often
impaired. Hence, the patient is not aware that he has filled
his mouth, and goes on cramming it with food, which makes
an alimentary mass larger than can pass through the oesopha-
gus. This course, even without the pharyngeal paralysis, in-

SUPPURATIVE ENCEPHALITIS OR CEREBRITIS. 251

terferes witli tlie act of swallowing. The feces are sometimes
passed involuntarily, but this is almost entirely a feature of
the last stage. Nausea and vomiting are present more or
less from the very first.

There may be either retention of urine from paralysis of
the bladder, or incontinence from paralysis of the sphincter.
Or both conditions may coexist, giving rise to a constant
dribbling.

These symptoms may be arranged in five classes, desig-
nated by the most prominent feature of each : the paralytiG,
the comatose^ the epileptiform, the apoplectiform, and the
maniacal.

Complications may and often do arise. Thus there may
be meningitis, temporary congestions, extravasation of blood,
effusion of serum, or some intercurrent visceral aflfection.

The tendency of acute encephalitis is to suppuration and
the consequent formation of abscess, and many of the symp-
toms enumerated are due to the supervention of this condi-
tion. Death ensues gradually from exhaustion or asphyxia,
or may take place suddenly from the bursting of the abscess
into the ventricles, or upon the surface of the brain.

Causes. — Is o age is exempt from the disease, although it
is more common in old persons than in adults of middle age
or young persons.

It is probably more common in males than females solely
from the fact that they are more subject to the exciting
causes of the disease. Among these are the inordinate use
of alcoholic liquors, venereal excesses, extreme intellectual
exertion, great emotional disturbance, and exposure to ex-
treme heat.

It may also be induced by disease of the internal ear, by
erysipelas affecting the head, or by severe attacks of scarlet-
fever, small-pox, or other eruptive disease.

The most common cause, however, is injury of the brain.

Diagnosis. — The diagnosis of suppurative encephalitis is,
in the first stages, difficult if not impossible ; the symptoms

252

DISEASES OF THE BRAIN.

being common, as I have already said, to several other dis-
orders. From cerebral haemorrhage the distinction can be
made without difficulty, for, although encephalitis may be
developed with rapidity and by an apoplectic seizure, the
tendency is for the subsequent phenomena to become pro-
gressively more marked, while in haemorrhage there is a
gradual amelioration. The pulse in haemorrhage is from the
first slow and regular, unless the medulla oblongata be the
seat, while in encephalitis it is rapid and irregular.

Meningitis is always associated with superficial encepha-
litis, and hence the symptoms bear a certain amount of re-
semblance to those of the affection under consideration.
But the latter is, in general, characterized by the facts that
the paralysis is more defined, both in intensity and location ;
that the delirium is less acute ; that the cephalalgia is not
so intense, nor the delirium so prominent or constant a phe-
nomenon.

In epilepsy the paroxysm is the main phenomenon of the
disease. When this ceases, the patient in general recovers
his ordinary mental faculties, but the epileptiform seizures
of suppurative encephalitis are never followed by complete
intellectual restoration.

The disease with which it is most likely to be confound-
ed is that which, from its obvious characteristics, is denomi-
nated general paralysis. I know of no diagnostic marks
between the two conditions, except that general paralysis is
usually of longer duration, and is especially apt to affect the
insane.

The symptoms due to tumors are often almost identical
in character with those attendant on abscess. The history
of the case is our only safe guide. The fact that the brain
has received an injury of some kind will indicate suppura-
tive encephalitis as the probable difficulty. A lady is, at
the moment of writing this, under my charge, who has been
successively treated by several of the most skilful diagnos-
ticians of this city, at times for abscess, and again for tumor,

SUPPURATIVE ENCEPHALITIS OR CEREBRITIS. 253

and I venture to say that no one, without the aid of a post-
mortem examination, can say which lesion exists.

Prognosis. — Suppurative encephalitis is invariably fatal,
if the disease does not terminate in resolution. As Jaccoud,
however, remarks, cases of alleged cure before the stage of
suppuration ia readied must always have an element of un-
certainty about them, and do not therefore permit us to
mitigate the unfavorable character of the prognosis. Drs.
Gull and Sutton, ' while stating that there is nothing in the
morbid anatomy of cerebral abscess which makes it neces-
sarily an incurable affection, admit that practically it is
irremediable. In this opinion I unhesitatingly concur.

Morbid Anatomy and Pathology. — Suppurative encephalitis
is a local disease restricted in its action, and hence affecting
a limited and well-defined region of the cerebral tissue.
This may vary from the size of a walnut to that of the
closed fist, and is ordinarily irregularly spherical in shape.
Although never of a diffused character, there may be, at the
same time, several centres of inflammation. The part most
frequently affected is the gray matter of the cerebrum — the
morbid process involving the white substance in its progress.
Next, the cerebellum appears to be a favorite seat. The
corpora striata, and the optic thalami, are also frequently
involved.

It sometimes happens that the pus which results from
the inflammatory action is not collected in a cavity, but is
infiltrated into the subjacent tissue. In such cases there is
no well-defined abscess, but a pulpy mass is found on exam-
ination after death, consisting of the elements of the brain-
substance in a more or less disorganized condition, with
those of the blood intermingled with pus — the whole of a
greenish-yellow color.

Again, tliere may be a collection of pus, but at the same
time the walls are imperfectly formed, and there is infiltra-
tion to some extent. Lastly, the puriform deposit is entirely
' Abscess of the Brain. Reynolds's System of Medicine, vol. ii., p. 544.

254

DISEASES OF THE BRAIN.

limited by a membrane consisting of connective tissue, and
forming a cyst. The cerebral substance in contact with the
walls of an abscess gradually breaks down, and hence the
cavity undergoes constant enlargement in all directions, but
especially in the lines of least resistance. If the abscess is
near the surface of the hemisphere, the tendency is to en-
large toward the external periphery ; if it is situated in the
central part, in the corpora striata or optic thalami, the ab-
sorption of the peripheral tissue takes place in the direction
of the ventricles. In the first instance, when the rupture
ensues, the pus will be extravasated into the cavity of the
arachnoid ; in the second, it will be poured out into the
ventricular cavities. In either case, coma and death will
result if the amount of pus be sufficiently large. It has
happened that the pus has escaped from the cranium by the
nose or ear. A lady now under my charge experienced
this result several weeks since ; a large quantity of purulent
matter making its exit through the posterior nares. She is
still alive, in full possession of her reasoning faculties, and
her articulation perfect, but with the loss of sight in both
eyes, paralysis of the right side of the face, the left arm,
and leg, and suifering the most intense and constant pain
in her head. The seat of the lesion is probably partly in
the right half of the pons Yarolii. The suppurative ac-
tion is doubtless still going on, and I regard her death as
inevitable.

The substance of the brain in contiguity with the abscess,
as already stated, undergoes disintegration. This is in the
nature of softening.

CHKONIC CEEEBEAL ABSCESS.

Suppurative inflammation of the brain, terminating in
the formation of abscess, may be of a chronic character, the
course of the disease extending over several months. This
is especially apt to result from disease of the internal
ear.

SUPPURATIVE -ENCEPHALITIS OR CEREBRITIS. 255

Cases have been reported by Abercrombie/ Lallemand,^
Toynbee,' Kibiere,* and others, and three have come under
my own observation.

Chronic abscess may also result from injuries of the
brain or skull, and from suppuration set up around a clot
due to extravasation of blood.

As in the acute form of the disease, there are no very
characteristic symptoms indicating the formation of abscess.
Indeed, in some cases there are no symptoms at all referable
to the brain for the whole period of the course of the dis-
ease, till a short time before death. A great part of a lobe
may be destroyed, and even both anterior lobes almost en-
tirely obliterated, and the patient continue to manifest his
ordinary degree of intelligence.

Ribiere ^ has collected a number of interesting cases, sev-
eral of which almost overturn some of our most definite
ideas of cerebral physiology and pathology. Thus, he cites
(Observation II.) the case of a man who entered the Hopital
de la Pitie, January 27, 1866. The patient was depressed,
answered questions with difiiculty, and complained of a
violent pain in the head. The symptoms M^ere supposed to
indicate the existence of typhoid fever. Two days subse-
quently a purulent discharge was noticed from the right ear,
and, the pain in the head persisting, the diagnosis was
changed to suppurative otitis, with probable caries of the
petrous portion of the temporal bone. Leeches were applied
behind the ears and purgatives administered, after which
the patient felt so far well that he determined to leave the
hospital. He went to work again, and, on the 12th of Feb-
ruary, attended a ball. The following morning, pus, mixed

' On Chronic Inflammation of the Brain and its Membranes. Edinburgh
Medical and Surgical Journal, vol. xvi., 1818, p. 265, et seq.

* Op. cit., p. 80, et seq.

' The Diseases of the Ear, etc., Philadelphia, 1860.

* Des Abc^s de I'Encephale Consecutifs h. la Carie du Rocher. Th^se de
Paris, 1866.

Op. cit.

256

DISEASES OF THE BRAIN.

with blood, was discharged from the right ear, and, the ten-
dency to stupor reappearing, he again presented himself at
the hospital. It was then ascertained that the flow from
the ear had begun several years previously, but had ceased
for the two years immediately preceding his first entrance
into the hospital.

On the 14th he was in a state of not very intense stupor,
since he was able to complain of the pain in the head ; his
pulse was 60, full and hard, and pus was passing from the
right auditory canal. By the 16th of February the stuj^or
had increased. There was no paralysis, deviation of the
face, nor alterations of sensibility. The patient understood
questions put to him, but answered slowly and imperfectly.
The eyelids were closed, light appeared to be unpleasant,
and the purulent flow still continued. He died at nine
o'clock that night, without convulsions.

The post-mortem examination of the head revealed the
following condition :

The external auditory canal was filled with desiccated
purulent matter; there was neither abscess nor abnormal
redness about the ear.

The superior longitudinal sinus was gorged with blood,
the veins were black and dilated ; the brain appeared con-
gested, but a yellow tint of the right cerebral lobe was
noticed. At the inferior face of this lobe, where a rupture
had occurred in handling the brain, a quantity of pus esti-
mated at one hundred grammes (about three ounces) flowed
out. This was of a greenish color, and of offensive odor.
The cavity left was about the size of a hen's egg, and was
bounded by red, indurated, and thick walls. The pus, which
during life had flowed from the auditory canal, had not
come from the abscess, but from the carious petrous portion
of the temporal bone.

Around the abscess the substance of the brain was yel-
low and softened. Three-fourths of the middle and poste-
rior lobes were infiltrated with pus and softened in texture.

SUPPURATIVE ENCEPHALITIS OR CEREBRITIS. 257

The capillaries were not visible to the naked eye ; the con-
volutions of the island of Eeil were not recognizable, and
the neighboring convolutions were not now distinct. The
corpus striatum of the right side was healthy in its anterior
fourth. In the rest of its extent it was softened. The optic
thalamus was also softened, as were likewise the roots of the
optic nerve. We see that, in this case, as Eibiere remarks,
a considerable abscess had destroyed, in great part, the cor-
pus striatum and optic thalamus, and that, nevertheless, the
patient had been able to work till within a few days of his
death, and was so slightly paralyzed as to be able to attend
a public ball. Aside from a certain hebetude, the intellec-
tual faculties were not deranged.

Another patient observed by Kibiere presented an entire
absence of cerebral troubles, no paralysis, no contractions,
no convulsions ; the sensibility was intact, and the intelli-
gence was active. JSTevertheless, there was a degree of stu-
pidity expressed in the countenance, and the expression was
dull.

Still there is almost always some pain in the head, which
may be irregular as regards its location and character, or
may be coniined to one particular spot.

In one of the cases under my observation, there was very
acute pain, almost constant nausea or vomiting, a strong
tendency to coma, and hemiplegia of the left side, coexisting
with purulent discharge from the right ear. The patient,
who had a short time previous suffered an attack of scai-let
fever, to which the ear-trouble was due, died suddenly coma-
tose, but without convulsion. Examination after death
showed the existence of caries of the petrous portion of the
temporal bone, and an abscess containing about two ounces
of pus in the middle lobe of the right hemisphere. The
right corpus striatum was softened in about half of its ex-
tent.

In the other case there had been profuse discharge from
the right ear for several years, unattended by any cerebral
17

268

DISEASES OF THE BRAIN.

symptoms except occasional pain and headache, which were
supposed by the family to be due to gastric derangement,
and for which no medical advice was ever asked. One morn-
ing the patient, a young lady, twenty years of age, was sud-
denly roused from bed by an alarm of fire. In her hurry to
dress herself, and in the confusion of the moment, she struck
her head against the edge of an open door. She immediate-
ly felt a severe pain in the head and cried out, but almost
instantly sank down to the floor in a stupor, from which she
never emerged, death ensuing within five hours. On remov-
ing the calvarium a large extravasation of pus was discov-
ered under the arachnoid, covering the right hemisphere,
and it was discovered that an abscess, the cavity of which
was as large as a small orange, liad occupied the middle lobe,
and had ourst through the convex superior surface by rup-
turing the cerebral substance. The petrous portion of the
temporal bone of that side was carious, and communicated
by several very small openings with the abscess.

When speaking of cerebral haemorrhage, I have referred
to another case in which there was abscess of the cerebellum,
produced by injury of the skull. In this instance there were
notable symptoms, vertigo, convulsions, nausea, vomiting,
and violent pain in the back of the head. At first there was
no paralysis, but the patient subsequently became paraple-
gic, and died in convulsions. Examination after death dis-
closed an abscess, the cavity of which comprehended nearly
the whole of the left lobe of the cerebellum.

Although recovery from chronic abscess of the brain
never takes place, yet life is often prolonged for several
years, even when there may be marked symptoms of cere-
bral disorder. And then when death occurs it is generally
suddenly, with or without obvious exciting cause.

Treatment. — The treatment of acute suppurative ence-
phalitis is altogether palliative. Symptoms, such as pain,
vertigo, and vomiting, may be controlled to a certain extent.
I have derived considerable benefit from the extract of In-

SUPPURATIVE ENCEPHALITIS OR CEREBRITIS. 259

dian hemp, given in conjunction with the bromide of potas-
sium. The doses of Squires's extract may range from half a
grain to two grains three times a day, with from thirty to
forty grains of the bromide, either of potassium or sodium.
The pain and irritability of the nervous system are greatly
lessened by these remedies, and thus the patient's condition
rendered more tolerable.

When there is reason to suspect a syphilitic origin, mer-
cury and iodide of potassium may be administered theoreti-
cally with some prospect of success, but practically with
very little benefit. The medicines should be given in fre-
quently-repeated doses — calomel being the preferable mer-
curial— so as to bring the system, as soon as possible, under
their influence.

Bloodletting, local and general, blisters, tartar-emetic,
and other measures calculated to depress the powers of the
system, are worse than useless.

In suppurative disease of the internal ear, probably due
to caries of the petrous portion of the temporal bone, pre-
ventive measures against chronic abscess may do something.
Leeches applied to the mastoid j^rocess, and blisters behind
the ear, are indicated, and mercury with iodide of potassium
will afibrd a chance of a beneficial result. The solution of
the bichloride of mercury with iodide of potassium in water
constitutes an eligible preparation. The flow of pus should
be facilitated, and the propriety of trephining the mastoid
cells may be a question for consideration. The manage-
ment of injuries, with a view to preventing abscess, is to be
conducted upon very obvious surgical principles.

CHAPTER XII.

DIFFUSED CEREBRAL SCLEROSIS.

By diffused cerebral sclerosis is to be understood a mor-
bid condition of some part of the brain characterized by
induration and atrophy of the tissue, and not distinctly
circumscribed except by the anatomical limits of the region
affected.

It is not a disease which can be recognized with any
great degree of certainty or even of probability during life.
Is is, however, a well-marked pathological condition, giving
rise to very prominent symptoms. Of late years the affec-
tion has not been much noticed, except incidentally, by a
few writers of special treatises — though, under the name of
" induration of the brain," it received considerable attention
many years ago.

The symptoms by which it is characterized are by no
means peculiar to it, though, when taken collectively, they
give ns some reason to diagnosticate sclerosis as tlieir cause.
A number of cases have come under my observation in
which the lesion was probably diffused cerebral sclerosis ;
but I have never had the opportunity of verifying my diag-
nosis by post-mortem examination. Tlie remarks, therefore,
which I shall make on the morbid anatomy will mainly be
based upon the studies and observations of other writers.

Symptoms. — The symptoms of diffused cerebral sclerosis,
like so many other brain- affections, are connected with the
mind, with sensibility, and with the power of motion. It
generally makes its appearance during infancy, and produces

DIFFUSED CEREBRAL SCLEROSIS.

261

an arrest of development in the part of tlie brain affected,
and consequently in certain parts of the body. The initial
phenomena are those of congestion and inflammation, dur-
ing the course of which epileptic convulsions frequently
ensue. These may be few in number, and may cease in a
few days, or they may be very frequently repeated and last
for several years, or during the whole life of the patient.
The mind remains undeveloped, speech, if already acquired,
often becomes imperfect, and, if not yet present, may never
be commenced. The limbs, usually only on one side of the
body, become paralyzed, and do not grow with the same
rapidity as those on the sound side. Contractions are very
apt to take place, from the fact, probably, that the normal
degree of antagonism between the muscles is destroyed, and
that those not so much paralyzed as others draw the limbs
in the direction of their action. It is quite common, there-
fore, in the affection under consideration, to And the fingers
drawn into the palm of the hand, the wrist flexed on the
forearm, the forearm on the arm, and the arm drawn back-
ward by tlie action mainly of the latissimus dorsi. In the
lower limbs, club-feet are produced in a similar manner.

It is not uncommon, too, to find one or more senses weak
or altogether lost, and the general sensibility of the body di-
minished on one side.

The urine and faeces are often passed involuntarily, or
else the patient, from never having acquired a sense of pro-
priety or cleanliness, passes them whenever he chooses, at
any time or place.

"With this general idea of the symptoms, I proceed to re-
fer somewhat at length to its history, in the course of which
I shall quote several cases in illustration of its progress.

The first to direct specific attention to the disease under
consideration was M. Pinel,' the younger, who, in a memoir
read before the French Academy of Sciences, May 27, 1822,

• Recherches d'Anatomie Pathologique sur I'Endurcissement du Systeme
Nerveux. Journal de Physiologic de Magendie, t. ii., 1822, p. 191, et seq.

262

DISEASES OF THE BRAIN.

broufflit forward several cases in illustration of what be de-
nominated " induration of the brain." I quote the first case
in full as a typical example of the affection :

Beler, aged eighteen years, an idiot from birth, was ad-
mitted into the Salpetriere Hospital, June 1, 1821. The
patient was paralyzed in the left arm and leg. She could
not use this arm, for the hand was strongly flexed on the
forearm, and could not be extended. She walked with great
difficulty, dragging the left leg. Her intellectual faculties
were very much restricted; she comprehended only the
questions which were addressed to her relative to her health,
her intelligence not extending beyond that point. She had
also great difficulty in articulating the words yes and no,
which were the only words she could speak. She had no
particular habit, was always calm and tranquil, and had to
be anticipated in all her wants. She was subject to occa-
sional attacks of epilepsy ; but, when the paroxysms came
on, she had fits almost without intermission for thirty or
•forty hours. They returned about every twenty-five days.
On the 4th of December, 1821, the patient was taken with
a series of epileptic fits, almost continual in character, which
lasted during four days, the paroxysms succeeding each other
with inconceivable rapidity. During these continuous con-
vulsions the right limbs were afi'ected with violent move-
ments. The left limbs, which had been paralyzed for a long
time, were also strongly agitated, and the general sensibility
was abolished. The face was red, the eyes were twisted,
the dejections were passed involuntarily, the pulse was fre-
quent and irregular, and the respiration unequal and jerk-
ing. The patient died on the fourth day, without there
having been any remission in the symptoms.

Post-mortem Examination. — " General marasmus ; re-
markable emaciation of the paralyzed limbs. The cranium
was thick, eburnated, and very hard to break. The me-
ninges were pale and healthy. The right lobe [hemisphere]
of the brain was very much smaller than the left, it was

DIFFUSED CEREBRAL SCLEROSIS.

263

atrophied ; the convohitioiis were almost obliterated and
very small, especially in the frontal and occipital regions.
They were large and deep in the inferior part. The corti-
cal substance was thicker than it generally is ; the lateral
ventricle was very small and dry. The substance of the
brain, throughout the whole extent of this right lobe [hemi-
sphere], and notably above the ventricle, was of remarkable
hardness, and it was torn with difficulty by the fingers, the
tissue separating in longitudinal bands which converged
toward the corpus striatum.

" The left lobe [hemisphere] of the brain, much more
developed than the right, was of the softness and consist-
ence of the healthy brain-tissue, and this condition made
the alteration in the right lobe [hemisphere] more obvious."

The rest of the description refers to other organs.

In regard to this case, M. Pinel remarks that to the
pathological condition, the loss of the power of motion in the
whole of one side, the almost complete annihilation of the
iatellectual faculties, and probably the epileptic fits, are to
be ascribed. The condition — which is frequent with idiots,
but of which it is often difficult to estimate all the various
symptoms — is ordinarily revealed less by the paralysis of
the limbs than by the distortions which it determines in the
feet and the hands. Three other cases are adduced, in one
of which the cerebellum was also in part indurated. M.
Pinel, as the result of his observations of the morbid anat-
omy, states that the nervous tissue resembles a compact in-
organic mass ; its consistence and density are those of hard-
boiled white-of-egg ; the cerebral substance is atrophied ; it
appears entirely deprived of blood-vessels — the eye perceiv-
ing no trace of capillaries. The induration appears to affect
more particularly the medullary substance than the gray
substance ; it was never observed in this last-named tissue.

Griesinger,^ under the name of "difi*used hypertrophy

' Die Pathologic und Therapie der psychischen Krankheiten. Zweite Au-
flage, 1861, p. 301. Also New Sydenham Society translation, p. 359.

264

DISEASES OF THE BRAIN.

of the connective tissue of the brain," describes the affection
now under consideration, and refers to an interesting case
reported by Isambert,* in which a microscopical examina-
tion of the altered tissue was made. It occurred in an
idiotic child, two years of age. The ventricular walls, the
great ganglia, the pons and peduncles, were solid and hard;
their tissue was elastic, like caoutchouc ; the nerve-tubes in
the white substance were almost completely destroyed and
an amorphous granular substance occupied their place ;
there also existed newly-formed fibrous connective tissue.
In regard to such cases, Griesinger remarks that, when we
are told that a hitherto healthy and well-developed child,
about the period of dentition, or during the second or third
year, suddenly became feverish, was attacked with convul-
sions and delirium, fell into a slightly soporific state, and
soon afterward apparently recovered, but with the intellect-
ual and physical development checked, the condition may
be due to one of two morbid processes : either there are
slight congestion and inflammation of the membranes, or
there is encephalitis, which, after passing out of the acute
stage, suspends further development in the affected parts.
The mind, therefore, ceases to expand ; walking, if begun,
is arrested ; speech remains as it is, or is altogether lost ;
one side of the body does not grow so fast as the other ;
and convulsions, paralysis, and contractions, are present.

A case in point, referred to by Griesinger, I quote from
Calmeil : ^

"M. Alfred, born at Havre, single, aged twenty-two
years, came to the Bicetre, where he resided twenty-two
months : he had been an invalid since infancy.

" Until about three years of age, he had exhibited no pe-
culiarity as regarded intelligence — resembling other children
of his years.

" At this period, however, he was attacked with measles,

* Compt. rend, et Mem. de la Societe de Biologic, t. ii., 1856, p. 9.

^ Traite des Maladies Inflammatoires du Cerveau, Paris, 1859, t. ii., p. 411.

DIFFUSED CEREBRAL SCLEROSIS.

265

wMcli was considered mild in form, and from wliich lie had
nearly recovered, when he was seized with a succession of
severe eclamptic paroxysms. During twelve hours, it was
impossible to rouse him from the coma, and general convul-
sions were present almost without interruption.

" The day after, it was perceived that he was deaf, blind,
and incapable of articulating the least sound ; the convul-
sions had ceased.

" At the end of fifteen days he recovered his hearing ;
after a year he could say a few words ; but the retinse con-
tinued insensible to impressions of light.

" It was now perceived that he walked with a certain
degree of difficulty, and that he could hardly use the right
hand. At times, also, he lost consciousness, but without
falling, and it was subsequently recognized that these at-
tacks were epileptic.

" Until the age of thirteen, the intelligence of M. Alfred
underwent scarcely any development, and he remained im-
becile notwithstanding all the effi)rts made for his improve-
ment. He nevertheless acquired a knowledge of a certain
number of words, and he could make himself understood
whenever he had a want to gratify.

" At the age of nineteen he presented the symptoms of
an almost complete state of idiocy. He comprehended
some things, and could imperfectly articulate a few words.
He was not evilly disposed, but he was incapable of attend-
ing to his person, and even of eating without assistance.

" He could take a few steps by supporting himself against
the wall, on articles of furniture, or a cane, but he dragged
his feet on the ground, and his right leg appeared to be
weaker than the left. The right arm was contracted and
almost immovable. Tactile sensibility was not affected
anywhere. He did not appear to perceive objects placed
immediately before his eyes, and the pupils were dilated
and insensible to the sudden accession of light. As regard-
ed the bladder and rectum, he evacuated them without

266

DISEASES OF THE BRAIN.

seeming to exercise the least restraint of cleanliness or pro-
priety.

" The epileptic paroxysms occurred with long intervals
between them, and presented no characteristics worthy of
special mention. The complexion was pale, and the body
emaciated and notably weak.

"Dm'ing the month of January, 1827, there was fre-
quent cough, combined with abundant expectoration, diar-
rhoea, and other symptoms of phthisis." He died in Feb-
ruary of the same year.

Autopsy. — The whole of the right side of the body was
much less developed than the left side. The right arm and
leg were especially emaciated and thin. " The face was free
from distortion, and the cranium, without being deformed,
was small and very narrow. The greater part of the cra-
nium was abnormally thick, and contained an excessive
amount of calcareous matter.

" The dura mater was without change, and did not ad-
here to the osseous surfaces.

" A very considerable quantity of serum was infiltrated
into the meshes of the pia mater — principally toward the
middle and convex surface of the two cerebral hemispheres.
The pia mater was thickened, but was not adherent to the
convolutions.

" The left cerebral hemisphere was notably smaller than
the right ; the posterior lobe being particularly remarkable
for its diminution. The convolutions were flattened, and
were as thin as the blade of a knife, were resistant to the
touch, and were of a clear yellow color. The middle and
anterior lobes were neither of them of ordinary size.

" The posterior lobe of the right hemisphere was less de-
veloped than in a healthy brain, but the number of atro-
phied convolutions was small.

" On cutting into the left posterior lobe with a bistoury,
its tissue was found to be white, compact, homogeneous,
and very resistant. It might be said that the cerebral sub-

DIFFUSED CEREBRAL SCLEROSIS.

267'

stance liad become doughy, and that an element, foreign to
its nature, gave it an excessive degree of hardness.

" On the right, the atrophied convolutions of the poste-
rior lobes were difficult to cut ; their structure was compact,
but the induration of the nervous tissue did not extend
deeply into the thickness of the lobe.

" In all other parts of the brain the white and the gray
substance, as well on the left as on the right side, were ap-
parently, in all respects, in a healthy condition.

" The corpora striata and the optic thalami were free
from change, either as regarded their volume or their struct-
ure.

" The pons Yarolii, the tubercula quadragemina, and the
peduncles of the cerebrum, and cerebellum, were in a nor-
mal state.

" The spinal cord relatively, and perhaps even absolutely,
appeared to be larger than was natural.

" The optic nerves were atrophied, of a glossy white
color, and very hard."

. Other cases, similar in general features, are adduced by
Calmeil.

In the very interesting monograph of Cotard,* to which
reference has already been made, the relation of sclerosis to
atrophy of the brain is clearly pointed out. As indicating
a certain set of symptoms, in existence with a definite patho-
logical state, I quote the following case, No. XXIX of his
series :

" C, aged fifty-eight years, an inmate of the Salpetriere
since 1828, entered the infirmary April 25, 1865, under the
charge of M. Charcot.

• " She gave the following information, which she said she
had from her mother, and from other persons wlio had
brought her up : At the age of eighteen months she had
three attacks of convulsions, which left her paralyzed on
her right side. She had never had convulsions since. She
' Etude sur 1' Atrophic partielle du Cerveau, Paris, 1868, p. 49.

268

DISEASES OF THE BRAIN.

had already begun to walk when the seizures took place, but
she did not walk again till she was three years old.

"According to the information given by the superin-
tendent of her ward, who had known her since her entrance
into the hospital, her intelligence had always been weak ;
she was incapable of attending to herself; she could read
tolerably well, and could sign her name ; she had always
spoken without difficulty.

" She had been employed with coarse sewing, and had
invariably been docile and attached to those who took care
of her.

" Her health had always been good, though she had,
when about the age of twenty-five or thirty, several attacks
of hysteria. Menstruation had been regular, and had ceased
when she was forty-five.

" For about a year the patient had been the subject of
frequent attacks of vomiting, or of epigastric pain. At the
time of her admission to the infirmary, she was very much
emaciated and very cachectic.

" Her intelligence did not appear to have been recently
enfeebled ; she could read, sign her name, and speak with-
out difficulty.

" Her senses seemed to be intact ; sight was good in both
eyes, and the pupils were equal. There was no facial pa-
ralysis, and the tongue was protruded straight.

" The right arm was emaciated, atrophied, and contract-
ed ; the forearm was pronated and semi-flexed on the arm ;
the hand was flexed on the forearm, and inclined toward the
ulnar side ; the fingers were flexed in the palm of the hand,
particularly the ring and little fingers ; the index-finger was
semi-flexed, and the thumb was extended.

"It was possible, without very great force, to bring the
several parts of the limb almost into a state of extension,
but, as soon as it was left to itself, it resumed its habitual
position. The patient could execute a few movements with
the shoulder and the elbow, but the wrist was absolutely

DIFFUSED CEREBRAL SCLEROSIS.

269

paralyzed, and tlie fingers could only be moved to a very
limited extent.

" The right leg was less atrophied, and there was no
other deformity than a talipes equinus. The patient walked
with a cane.

" The sensibility of the right side was intact, and no
very notable difference of temperature was observed be-
tween the liealthy and the paralyzed sides.

"The patient died May lYth, after symptoms of acute
peritonitis.

" Autopsy. — Cancer of the stomach, circumjacent ab-
scess, purulent peritonitis.

" No . exterior deformation of the cranium ; on the left
side its walls were thick, doubly and triply so at some
points ; the frontal sinus extended to the left of the mesial
line, and communicated with a large cavity situated in the
orbital arch, which was composed of two thin osseous la-
mellae.

" The left middle fossa was smaller than the right, and
the right cerebellar fossa was smaller than the left.

" The dura mater being incised, a large quantity of serum
escaped from the left side. The left hemisphere was very
small, shrivelled, and in length and breadth scarcely two-
thirds the corresponding dimensions of the right hemisphere.
The convolutions were pressed together, were hard, and of
a whitish color.

" On the external face of the middle lobe, behind the
posterior marginal convolution, and on the prolongation of
the fissure of Sylvius, there was a deep depression running
upward and backward, and three or four centimetres in
length. At the bottom of this depression the convolutions
were reduced to little ridges, which were hard, and of a yel-
low color. The ventricle was considerably dilated ; the cor-
pus striatum did not appear to be perceptibly diminished in
volume, but the optic thalamus was hardly one-fourth as
large as that of the opposite side. There was considerable

270

DISEASES OF THE BRAIN.

atrophy of the left crura of the fornix, and of the mammary
tubercle.

" The olfactory and optic nerves of the left side were
apparently healthy ; the tubercula quadrigemina were not
atrophied.

" The right hemisphere was healthy.

" The right hemisphere of the cerebellum and the middle
cerebellar peduncle of the same side were atrophied."

Examined with the microscope, the indurated convolu-
tions of the left hemisphere presented an enormous quantity
of amyloid corpuscles and of nuclei of connective tissue.

The following cases I select from others of similar char-
acter which have occurred in my own practice :

Case I. — J. S., a boy, aged five years, was brought to me
in the autumn of 1869, to be treated for epilepsy. The par-
oxysms occurred several times a day, and had originated
when the child was two years of age, in consequence, as the
mother thought, of a fall.

At that time he could say a number of words, and was
rapidly learning to talk ; his intelligence was good, and he
had been walking for several months.

But after the first convulsion he ceased to speak and to
walk, though he continued up to the time I first saw him to
give his attention to very striking objects, such as noisy tops,
bright-colored articles, and, above all, music and soldiers.
During this period he had at least six exacerbations, charac-
terized by pain in the head, repeated convulsions, and coma.

When he was about two years and a half old it was ob-
served that he did not move the left arm and leg so freely as
the right, and soon afterward he ceased to move them at all.
The toes then began to be drawn under the sole of the
foot, and the heel was raised. Then the leg became flexed
on the thigh, and soon afterward the fingers of the left hand
and thumb were gradually bent so as to press strongly against
the palm. The wrist followed, and then the forearm. Both
limbs were greatly atrophied.

DirrUSED CEREBRAL SCLEROSIS.

271

When he came under my examination he was having epi-
leptic convulsions, both of the grand and ^etit mal, every-
day. There was no deformity of the skull, though it was
certainly small for his age. His mind was feeble, and he
did not give attention to any remarks made to him, but
bright objects at once attracted his gaze, and he made efforts
to get hold of them.

I examined the fundus of the eyes witii the ophthalmo-
scope, and discovered an anjemic condition of the retinae and
atropliy of both optic disks.

I gave it as my opinion that the child was suffering from
diffused cerebral sclerosis, involving the left hemisphere ;
and that there was scarcely any prospect of material ameli-
oration in his mental or physical condition. '

Case II. — A female, aged eight years, entered the New
York State Hospital for Diseases of the Nervous System,
June, 1870, having previously been a patient at my clinic at
the Belle vue Hospital Medical College. When quite an in-
fant she had suffered from epileptiform convulsions, which
had been almost immediately followed by paralysis of the
right upper and lower extremities. The convulsions recurred
at short intervals, and atrophy of the paralyzed limbs, with
contractions of the fingers, hand, and forearm, supervened.
She learned to walk, however, quite well, and also to talk
without any very notable defects.

Her mind was weak, and she was extremely silly in her
behavior ; she had never learned to read.

Under the use of the bromide of potassium her epileptic
paroxysms ceased, but the contractions and atrophy of the
right arm resisted treatment by galvanism and mechanical
appliances. The leg acquired much more power under the
treatment than it had previously possessed.

Case III. — W. W., a gentleman, aged forty-three, came
to me, December 11, 1869, to be treated for what his physi-
cian and friends regarded as softening of the brain.

About six months previously he had experienced, on

272

DISEASES OF THE BRAIN.

awaking in the morning, great difficulty in extending the
left hand and fingers, and through the whole day there was
a decided tendency manifested for the latter to close and the
hand to be flexed upon the forearm ; and this gradually, day
after day, became stronger, till at last neither the hand nor
fingers could be extended.

Then the corresponding lower extremity became involved
in a similar manner, and about a month after noticing the
first symptom he had an epileptiform convulsion, and this
was repeated twice the following day. Since then the fits
have occurred at intervals of four or five days. "With the
contractions in the limbs of the left side there was gradual-
ly-advancmg paresis until, when he came under my observa-
tion, both arm and leg were almost completely paralyzed.
Atrophy of both extremities was present to an extreme de-
gree, and sensibility and electro-muscular contractility were
almost entirely abolished.

His mind was also notably impaired. He laughed im-
moderately at every question I put to him, and had a de-
cided expression of imbecility. His speech was not aftected
to any remarkable degree, except as regarded extreme slow-
ness of utterance. He had previously to his illness been a
ready and quick speaker. My diagnosis was difi'used cere-
bral sclerosis, and I gave an unfavorable prognosis. The
treatment, which will be considered under its proj)er head,
was, however, successful to a very considerable extent.

It will be seen, from the foregoing account of the symp-
toms, that diffused cerebral sclerosis is characterized mainly
by weakness of intellect, paralysis, and muscular contrac-
tions.

Causes. — The predisposing causes of the affection under
consideration are not thoroughly understood. The disease
appears to be much more frequent in infancy, although it
lasts to the period of old age, and sometimes originates at an
advanced time of life.

The exciting causes are likewise imperfectly known. In-

DIFFUSED CEREBRAL SCLEROSIS.

273

juries of tlie skull from falls or blows and lioemorrliagic cysts
appear to have some influence in originating the disease, but
more generally it is developed, so far as we can perceive,
spontaneously.

Diagnosis. — The diagnosis of diffused cerebral sclerosis
must always be more or less uncertain, for the reason
that the symptoms are met with in other very different
affections. In children a similar set of phenomena may be
the consequence of arrest of development in the brain with-
out any alteration of its structure recognizable by our means
of observation. In the case of an idiotic child affected with
convulsions, hemiplegia, and muscular contractions, I found,
on post-mortem examination, the left hemisphere markedly
smaller than the right, but I could detect no change of any
part of its structure.

Symptoms like those met with in diffused cerebral scle-
rosis may result from brain-tumors of various kinds.

In adults the disease is readily discriminated from cere-
bral haemorrhage and embolism by the gradual character of
its advance, and by the mental symptoms being more strong-
ly pronounced. But from softening the diagnosis cannot
always be made out, and an opinion must be formed from
the history and phenomena in each individual case.

From thrombosis the diagnosis is equally difficult. Per-
haps the distinction may be made both as regards softening
and thrombosis by the facts that, though contractions are
met with in both these diseases, they are not such invariable
accompaniments as they are in diffused cerebral sclerosis,
and that they are never, as occasionally in the latter affec-
tion, a primary symptom.

Prognosis. — The prospect of complete recovery is very
gloomy, and even amelioration has hitherto been regarded
as out of the question. I am inclined, however, to think, as
the result of my own experience, that the condition of pa-
tients, apparently suffering from the affection in question,
may be decidedly improved by suitable medical treatment.
18

274

DISEASES OF THE BRAIN.

I have several times succeeded in arresting the convulsions,
strengthening the mind, increasing the strength and sensi-
bility of the paralyzed members, and relaxing the contrac-
tions. My success has been much more decided in cases
which had originated late in life — probably, for the reason
mainly that the disease was seen earlier in its course.

Morbid Anatomy. — This division of the subject has al-
ready been considered incidentally, to some extent, in the
remarks made under the head of symptoms, and in the de-
tail of cases quoted.

The most obvious feature detected by ordinary observa-
tion is the increased hardness and density which the cere-
bral tissue has acquired. This generally occupies a consid-
erable portion of one lobe, or may extend through the whole
of it, or may even affect a whole hemisphere. It is not dis-
tinctly circumscribed, but diminishes in intensity from the
centre to the periphery, and, according to Pinel, never in-
vades the gray substance.

The increased density is attended with atrophy when the
disease affects the adult, and with atrophy and arrest of de-
velopment when children are its subjects.

In order to understand the essential nature of the mor-
bid process which causes the brain to become indurated, a
few words in regard to cerebral histology are necessary.

Besides the nervous tissue of the brain, there is another
anatomical element present which fulfils the function of
binding the cells and fibres together, and giving the whole
substance its normal degree of consistence. According to
Yirchow,^ this, although analogous to, is different in some
respects from ordinary connective tissue. He gave to it the
name of neuroglia or nerve-cement.

Diffused cerebral sclerosis consists in the hypertrophy or
increased formation of this tissue, and the atrophy or disap-
pearance of the proper nervous substance. Atrophy of the
brain may, however, be due to other causes than sclerosis,

' Cellular Pathology, Chance's translation, London, I860, p. 277.

DIFFUSED CEREBRAL SCLEROSIS.

275

as in the case reported with great minuteness by Schroeder
van der Kolk/ and several of those cited by Lallemand/
Turner/ and other writers.

Pathology. — The symptoms which result from ditfused
cerebral sclerosis are those which we might expect to be the
consequence of a condition which essentially consists of a
disappearance of that part of the brain-tissue capable of pro-
ducing or transmitting nervous force, and the substitution
of another histological element which is of secondary im-
portance. They all indicate deficient cerebral power. It
is with the brain as with a muscle undergoing atrophy : less
force results from its action in correspondence with the ad-
vance of the process by which the characteristic anatomical
elements disappear.

Doubtless, if we had the opportunity of more thorough
study of the symptoms of diffused cerebral sclerosis, and
comparing them with the condition of the brain as found by
post-mortem examination, we should find that they varied
considerably in character, according to the part affected,
and we should probably have reason to believe that the
nervous cells which had disappeared — motor, sensitive, or
trophic — were in exact pathological relation with the symp-
toms observed. This special point has been well studied by
MM. Duchenne de Boulogne and Jouffroy,* in a recent pa-
per, devoted to a somewhat different disease, and to which
I have recently been enabled to add a few important data.

Treatment. — This division of the subject has scarcely re-
ceived any attention from authors. My experience, how-
ever, has sufficed to convince me that we can occasionally
improve the condition of the patient.

' A Case of Atrophy of the Left Hemisphere of the Brain, etc. New Syd.
Soc. trans. London, 1861.
Op. cit.

^ De 1' Atrophia partielle ou unilaterale du Cervelet, etc. Paris, 1856.

* De 1' Atrophic Aigue et Chronique des Cellules Nerveuses de la Moelle et
du Bulbe Rachidien, etc. : Archives de Physiologie, No. 4, Juillet et Aout, 1870,
p. 499.

276

DISEASES OF THE BRAIN.

If there are epileptic convulsions, tliej may be prevented
by the administration of the bromide of potassimn in doses
of at least twenty grains, three times a day, to an adult.
Larger doses may be necessary. On the cessation of the
convulsions, it will sometimes be found that the intelligence
at once begins to be developed.

The paralysis and contractions may sometimes be less-
ened by the persistent use of both the induced and primary
galvanic currents. The first named will often in the begin-
ning fail to act upon the muscles, in which case the latter
should be employed. This is always better for the contract-
ed muscles than the induced current. For the relief of the
paralysis it should be interrupted, for the relaxation of con-
tractions it should be constant.

As regards the central lesion, I think it may occasionally
be reached, when it has not had time to become very exten-
sive or profound. And the best and really only means I
know of are the primary galvanic current passed through
the brain, and the administration of the chloride of barium.

In using the galvanic current, the electrodes — wet
sponges — should be applied over the mastoid processes, and
kept there for a period not exceeding three minutes. Fif-
teen of Smee's cells will afford a current of sufficient inten-
sity. The application should be made about every alternate
day.

The chloride of barium may be given in doses of about a
grain three times a day. I usually administer it in solution,
according to the following formula: 5" Barii chloridi 3j)
aquse dest. ^ ]'> ft. sol. ; dose, gtts. xij three times a day.

I am unable to say that these measures have actually re-
moved the supposed sclerosis of the brain, and caused the
reformation of the atrophied cells, but I am very sure that
symptoms such as are attendant upon diffused cerebral scle-
rosis have several times been measurably dissipated by its
influence. Thus, in the third case mentioned as occurring
in my practice, the mind improved, the epileptic paroxysms

DIFFUSED CEREBRAL SCLEROSIS.

277

ceased, the contractions were relaxed, the paralysis lessened,
the affected limbs increased in size, and the further progress
of the disease was arrested. At the present date (December
30, 1870) the gentleman is able to take care of himself,
to walk tolerably well, and to use the formerly-paralyzed
arm for many purposes. In three other cases a like treat-
ment has been productive of almost as marked a degree of
benefit.

CHAPTER XIII.

MULTIPLE CEREBRAL SCLEROSIS.

In multiple cerebral sclerosis the lesion involves several
parts of the same ganglion, and consists of plates or nodules
of sclerosed tissue scattered throughout its substance.

It is only of late years that the affection in question has
been partially recognized as a distinct pathological condi-
tion associated with certain symptoms. These symptoms
were formerly, and still are to a great extent, confounded
with other groups similar in several prominent features, but
different altogether in anatomical relations, normal and ab-
normal.

Thus, under the designation of paralysis agitans, were
comprehended the phenomena due to multiple cerebral
sclerosis, multiple cerebro-spinal sclerosis, and muscular
agitation general or local — the result of very dissimilar le-
sions, or without discoverable morbid changes of any kind
— the one symptom of tremor sufficing to bind them to-
gether. Even by late writers the distinction is not clearly
made out.

It is, in the present state of our knowledge, impossible
to say in all cases what part of the intra-cranial mass is
affected. Still, we are not altogether without data on this
point, and an attentive consideration of the symptoms will
often, at least, enable us to say what ganglion of the en-
cephalon is the main seat of the lesion. But, mindful of the
fact that this work is intended to be practical, I shall not
venture to deal with pathological refinements, but will point

MULTIPLE CEREBRAL SCLEROSIS.

279

out, with as much succinctness as possible, one form of the
morbid process under notice — a form which I think I am
enabled to describe, from my own observations, with con-
siderable accuracy. That form I shall designate —

MULTIPLE SCLEROSIS MAINLY AFFECTING THE HEMISPHERES.

Symptoms. — Among the first symptoms noticed in this
affection is pain, which occurs in sharp paroxysms of short
duration. Sometimes the sensation is as instantaneous as
an electric shock. It is rarely the case that there is any
extreme constant pain experienced, though a feeling of ful-
ness or constriction is occasionally more or less permanent.

In a few cases the first observed symptom has been an
epileptic paroxysm.

It is not uncommon to meet with disorders of sensibility
in other parts of the body ; and these may either be anaes-
thetic or hyperaesthetic in character. Probably the most
common is a numbness of the ends of the fingers or toes,
which gives the sensation of cushions when objects are
touched, and which is generally confined at first to a single
upper or lower extremity. Shooting pains, something like
electric shocks, are also sometimes experienced. The prog-
ress of the disease is almost invariably slow, and hence sev-
eral months may elapse before any disorders of motility are
experienced. These, however, are the next symptoms to
make their appearance, and are generally first manifested
by the occurrence of tremor or trembling.

Tremor usually, but not always, is gradual in its devel-
opment, and may be restricted to narrow limits. It may at
first only be felt when the patient is unusually quiet, and
has not his attention engaged. Thus a gentleman told me
he had, for several months, only been sensible of a vibration
in his arm when he lay down at night. It was then — from
the description he gave me — limited entirely to the exten-
sor indicis of the left hand, and was, in the beginning, not
strong enough to move the finger. When I first saw him,

280

DISEASES OF THE BRAIN,

several years afterward, both arms and one leg were strongly-
agitated.

In another case, which I saw almost from the very be-
ginning, the tremor was restricted to the same muscle for
several months, and then gradually involved the extensors
and flexors of the hand. And, in several other instances
which have come under my notice, the onset was equally
gentle. But, as 1 have said, this is not always the case. A
gentleman consulted me in the summer of 18Y0, who, after
having experienced severe darting pains in the head and
through the limbs on the right side, was suddenly, while in
his field overlooking some work, seized with a violent trem-
bling of the right hand, which continued for several minutes,
notwithstanding his efforts to prevent it. A few days sub-
sequently, he had another accession of a similar kind in the
same limb, and by degrees the intervals became shorter,
until, in the space of a month, the tremor was constantly
present except when he slept, and, when I saw him, had ex-
tended to the whole arm and to the lower extremity of the
same side.

In another gentleman, much addicted to excessive

mental exertion, was awakened one morning by a violent
agitation in his right foot. He had been under my care
several months previously for severe headache and inability
to sleep, for which, believing them to result from inordinate
intellectual labor, I had recommended mental rest and horse-
back exercise. Under the use of these measures he had ap-
parently quite recovered, but against my advice had resumed
his literary labors.

He was not very confident how long the shaking of the
foot had lasted, but thought it was not more than a few sec-
onds.

Several days afterward, while writing, his right hand be-
gan to tremble slightly. He ceased his occupation, and
rubbed his hand with the other. The tremor stopped for
a moment only, again began, and has scarcely ever since

MULTIPLE CEREBRAL SCLEROSIS.

281

been absent. The whole side eventually became in-
volved.

The tendency of the tremor is always to extend. Be-
ginning in an extremity or a group of muscles, or only in a
single muscle, it goes on attacking others, until at last all
the limbs and even the head may become affected. By
preference, the advance of the tremor is lateral, that is, if
an arm be first invaded, the leg of the same side next suf-
fers, then the other arm, and then the corresponding leg.
Usually the head is the last part attacked ; but this is not
always so, as I have seen several cases in which the trem-
bling began in it.

For a long time the tremor is to some extent under voli-
tional control. A patient, for instance, will slap his tremu-
lous hand on his knee and for a few seconds can manage
to keep it quiet, but it soon begins to shake again, and,
though perhaps a second time he may arrest its movements
by a like process, the period of rest is shorter. Any change
of position is calculated to quiet the tremor for a time, and
thus the patient is every few minutes moving his arms or
legs in the attempt to get a little respite.

It is always increased by emotional disturbance of any
kind. A limb which may ordinarily be but slightly tremu-
lous, will shake violently from the excitement or anxiety
produced by making a visit to a physician. The effort to
keep it quiet will also often increase the tremor.

For a very considerable period after the beginning of
the disease, the shaking ceases during sleep, but eventually
this state affords no respite, and the patient is thus deprived
still further of his physical strength.

It is not often the case that the muscles of the face are
affected very early in the disease, but they frequently be-
come involved at a later period. In several cases I have
seen a constant tremor in the upper eyelid of one or both
sides, and in one instance this was the first manifestation of
the disease.

282

DISEASES OF THE BRAIN.

In another very remarkable case the first indication of
tremor was perceived in the left eyeball, which was by
clonic spasms of the internal rectus muscle kept in a state of
motion producing a kind of nystagmus. The upper lid of
the same eye next became affected, and then the tremor ap-
peared in the corresponding arm. The upper lip I have
several times seen tremulous, causing thereby an indistinct-
ness in the articulation.

I have never observed other muscles supplied by the
facial nerve to be involved in the tremor.

Occasionally the lower jaw is rendered tremulous from
the seat of the disease being at the origin or in the course
of the fifth nerve.

The tongue is sometimes affected with tremor, generally
at first on only one side, and I am inclined to think that the
muscles of the pharynx and larynx do not invariably escape.

The tremor is not, as some authors have asserted, only
manifested when voluntary movements are performed. This
is probably the case at least in the first instance with multi-
ple cerebro-spinal sclerosis, but it certainly is not in the
purely cerebral form now under consideration. Jaccoud'
calls attention to the error which has been committed rela-
tive to this point, and my own experience is uniformly in
support of the opinion he expresses.

The next symptom of importance to make its appear-
ance is paralysis ; and, when the sclerosis is limited to the
hemispheres or begins in them, it always follows the tremor.
On this point I have insisted in my lectures to the class of
the Bellevue Hospital Medical College, as an important in-
dication of the fact that paralysis agitans is often a cerebral
disease, and I am glad to find so exact an observer as Jac-
coud ^ asserting that the paralysis is often preceded by mus-
cular agitation or trembling.

At first the loss of power is slight, and, like the trem-
bling, is limited to a single muscle or group of muscles, but
> Traite de Pathologic interne, p. 194. ^ Op. et loo. cit.

MULTIPLE CEREBRAL SCLEROSIS.

283

it gradually extends until it involves the limbs of one side,
or even of both sides. According to my observations, it
follows the course of the trembling, no limb being ever par-
alyzed till it has for some time been affected with tremor.
In the face, however, the paralysis appears to be indepen-
dent of the tremor.

The period which elapses between the appearance of the
tremor and the accession of the paralysis varies in different
patients, and even greatly in the same patient. Thus some
muscles may exhibit notable loss of power in a few weeks
after they have begun to be agitated, while others remain
free from paresis for many months.

"When the loss of power affects the extensors or flexors —
especially in the former event — contractions may take place,
as in diffused cerebral sclerosis, and the limbs are thus more
or less distorted. The most common seat of this phenome-
non is in the upper extremity, and it generally begins in the
fingers, extending gradually to the wrist and elbow. But
in some cases, even though the antagonism between certain
groups of muscles be destroyed, there are no contractions.
The muscles of the head, face, and trunk, do not escape.
Strabismus, ptosis, and facial paralysis, are thus produced,
and the muscles concerned in speech, in deglutition, and in
respiration, likewise become involved. The sphincters, ac-
cording to my experience, are rarely paralyzed in the early
stages of the disease, but I have several times witnessed
paresis of the bladder among the primary symptoms.

A marked symptom which I have observed, and which
can only be distinctly shown by means of the dynamograph,
is the inability of the patient to maintain a continuous mus-
cular contraction, for even a short period. I have noticed
this as among the very first indications of paresis, and I am
disposed to think it exists even before the tremor is noticed.
Thus, a gentleman occupying a prominent public position,
and in whom I had diagnosticated multiple cerebral sclero-
sis mainly affecting the hemispheres, instead of making a

284: DISEASES OF THE BRAIN.

straight line with the pencil of the instrument, traced one
of which the following cut is 2, facsimile •

Fig. 8.

Repeated efforts only gave worse results.

In another case, that of a gentleman referred to me by
my friend Dr. Yan Buren, the line made was as follows :

Pig. 9.

Here the patient was able to maintain the contraction at
its original force for only about the sixth of a minute — the
time required for the paper to traverse the pencil being
exactly half a minute, and a third part of the line being
horizontal.

The ability to coordinate the affected muscles is always
impaired, and thus in voluntary movements there is agita-
tion independently of the esoteric tremor. This is seen not
only in active movements but in passive muscular contrac-
tions, such as those by which an article is held in the hand.
In such a case the fingers cannot be kept in apposition with
the object, but are moved about in a disorderly manner.
The incoordination is manifestly connected with the inabil-
ity to maintain a lengthened muscular contraction to which
reference has just been made.

Sometimes, by the strong effort of the will, assisted by
the sense of sight, these last two difficulties may for a little
while be overcome. A gentleman now under my charge,
suffering from the affection in question, cannot, for instance,

MULTIPLE CEREBRAL SCLEROSIS.

285

carry a glass of water to his lips except by looking at it
fixedly and concentrating all his volitional power upon the
act. His lower limbs are not yet affected, and he conse-
quently can coordinate them, in walking and other move-
ments, perfectly well.

In another lady, affected with multiple cerebral

sclerosis, undertook to help her invalid husband to rise from
his chair ; a band of music happening to pass the window,
she turned to look at it, and, at once relaxing her hold, let
him fall to the floor and injured him severely,

Zenker ' reports a case in which there was a similar loss
of the appreciation of the state of the muscles; and another
is mentioned by Reynolds," under the head of " muscular
anaesthesia." I am very sure that many cases of this last-
named affection are instances of multiple cerebral sclero-
sis of other ganglia, and I shall presently more specifically
refer, under a different head, to two remarkable cases which
have occurred in my own experience.

Another phenomenon closely related with this incoordi-
nation is generally present in multiple cerebral sclerosis,
and that is, that the patient loses that innate or early-
acquired knowledge of the exact situation of the several
parts of his body. We can all of us, not thus affected, close
our eyes, and touch, with the end of the finger, any particu-
lar point on the face or rest of the body, with the utmost
exactness. But a person with multiple cerebral sclerosis in-
volving the hemispheres cannot do this. Thus, in attempt-
ing, with the eyes shut, to place the end of the index-finger
on the middle of the eyebrow, ho misses that point, some-
times by as much as two inches ; and, no matter how fre-
quently he tries, he succeeds no better. It would appear
that, in such cases, the normal instinct of topographical re-
lation between the fingers and the cutaneous surface gen-

' Ein Beitrag zur Sklerose des Hims und Riickenmarks. Henle und Pfeu-
fer's Zeitschrift fiir Rationelle Medizin, Bd. xxiv., 1865.
' System of Medicine, vol. ii., p. 330.

286

DISEASES OF THE BRAIN.

erally, which all persons and many animals seem to possess,
is impaired.

The electro-muscular contractility is never, according to
my experience, diminished in multiple cerebral sclerosis, un-
complicated with similar lesions in the spinal cord.

The attitude and gait of a person affected with multiple
cerebral sclerosis are peculiar. In standing the body is gen-
erally inclined forward, the head falling toward the chest,
the trunk flexed at the pelvis, and the knees slightly bent.
In walking the action is similar to a jog-trot, the body being
still inclined forward, and the patient often moving with
considerable rapidity. I have had several persons with the
disease under my charge who could not walk at all, but who
could run with surprising agility. One of these, a gentle-
man advanced in life, sent to me by my friend Prof. Sayre,
was unable to take a step in my consulting-room. He was
carried down-stairs by his attendants with some difficulty,
and when he reached the front-door he was put on his feet.
He then told his servant to give him a push, which the man
did with all his might, and the old gentleman, being started,
went at a full run and jumped into his carriage without the
least difficulty.

There is often a strong tendency to plunge forward, and
at times there is an impossibility of controlling it except by
catching hold of some fixed object. Not long since I was
walking down Broadway, when I saw in front of me a gen-
tleman who was then under my charge, and in whom I had
diagnosticated multiple cerebral sclerosis. Although aware
of his peculiar impulsive gait, I had never seen it so strik-
ingly manifested as it was then. He went at a full trot,
threading his way among the numerous people in tlie street,
until, apparently exhausted, he would lay hold of a lamp-
post or awning-post and cling to it till he had recovered
his breath, to start off again in a similar manner.

This impulsion of the body forward makes it easy for the
patient to ascend a staircase, but, on the contrary, very diffi-

MULTIPLE CEREBRAL SCLEROSIS.

287

cult to go down one. The first case cf the disease in question
which I saw in this city, over six years ago, was character-
ized by an extreme degree of festination. It was that of a
maiden lady, over fifty years of age, who had been afiected
for several years. When she was going up-stairs no one
could perceive the least irregularity in her gait, but to go
down was impossible.

Sometimes, however, the tendency is to go backward.
This was the case, to a remarkable extent, in a gentleman, a
resident of this city, who was sent to me by my friend Prof.
Yan Buren. Every time he rose from his chair he was forced
to take several steps backward, and it was only by constant
mental effort that he was able to go forward at all.

The tactile sensibility is generally impaired from a very
early period in the course of the affection, and thus, the two
points of the sesthesiometer must be more widely separated
than in the normal condition of the system, in order to get
two separate impressions. This anaesthesia bears no neces-
sary relation to the region of skin covering the afiected mus-
cles. According to my experience, it is most marked at the
terminal extremities of nerves.

l^umbness of different degrees, pains of various kinds,
increased or diminished temperature, and excessive hyper-
sesthesia of the skin, may also exist.

The special senses may be affected to a variable extent.
Thus there may be amblyopia, or even complete blindness ;
the taste is very often impaired or abolished, and the hear-
ing rendered less acute.

The ophthalmoscope should always be employed to ex-
amine the fundus of the eye. The condition generally found
to exist is white atrophy of the optic disk, which is identical
in general features with sclerosis. The vessels of the retina
will usually be found small, the branches of the veins few in
number, and the choroid of a paler hue than is natural.

The course of multiple cerebral sclerosis is progressive.

The patient is finally unable to walk, the friction of his

288

DISEASES OF THE BRAIN.

shaking body against the bed abrades the skin, the dejections
are passed invohmtarily, and he dies either in coma, in con-
vulsions, or by a gradual process of asthenia, his mind par-
ticipating in the general decay. The duration of the disease
varies from a few months to eight or ten years. Generally
it runs its course in about five years.

Causes. — Age is certainly one of the most powerful pre-
disposing causes of multiple cerebral sclerosis mainly affect-
ing the hemispheres, and causing the symptoms heretofore
classed as paralysis agitans. Thus, of nine cases in which I
diagnosticated the disease in question, all were over fifty
years of age, and three were over sixty. I have seen numer-
ous cases of paralytic tremor in younger persons, but the
morbid condition had scarcely any points in common with
that now under notice. Cases, however, are on record in
which young persons were the subjects. There is some evi-
dence to support the theory that it is sometimes hereditary,
but the whole subject is so confused in the minds of most
authors that it is difficult to make out clearly what they refer
to under the designation of paralysis agitans. Of the nine
cases occurring in my own practice, private and hospital,
four had immediate ancestors who had suffered from some
form of tremor and paralysis. Whether the lesion was
purely cerebral, cerebro-spinal, or whether the disease was
entirely functional, I was not able to decide from the infor-
mation given.

The influence of sex is more readily ascertained and is very
evident. Seven of my cases were males and only two females.

Of exciting causes there are many. In two of my cases
it followed immediately on attacks of scarlet fever, in one
it was a sequence of typhoid fever, in one it ensued after
rheumatism, in one it was probably syphilitic, in two it was
apparently excited by great emotional disturbance, in one
by inordinate muscular exertion, and in two no cause could
be assigned, or at least there was not, in my opinion, any
sufficient exciting cause to be discovered.

MULTIPLE CEREBRAL SCLEROSIS.

289

Diagnosis. — Multiple cerebral sclerosis has heretofore been
confounded with other diseases, and its very existence as an
independent affection is doubted by my friend Dr. M. Cly-
mer,' and other writers. To this point I will return when
the morbid anatomy and pathology are discussed, and, as
in the foregoing account of the symptoms and causes, will
base my remarks under the present liead mainly on the re-
sults of my own experience.

The occurrence of " head-symptoms " is suflScient to di-
agnosticate multiple cerebral sclerosis from the functional
paralysis agitans, which is never a very serious affection, and
the seat of which is not centric. Besides, in the latter there
are no festination, alterations of sensibility, incoordination,
muscular ansesthesia, or inability to maintain a continuous
muscular contraction, while the paper of the dynaomgraph
traverses the pencil of the instrument. The functional dis-
order is more liable to occur in persons under fifty than in
those over that age. From the cerebro-spinal form of mul-
tiple sclerosis, which will be fully considered in another sec-
tion of this work, it is distinguished mainly by the facts
that the tremor makes its appearance before the paralysis,
and that the agitation is present whether voluntary move-
ments are being made or not.

With the purely spinal form it is not likely to be con-
founded by any one paying the slightest attention to the
phenomena of the two diseases.

From chorea it might in some cases not be readily dis-
criminated without a thorough study of the clinical history
and existing symptoms. But, though chorea sometimes
occurs in adults, and is generally accompanied by " head-
symptoms," the two affections possess few other phenomena
in common.

In the first place, the mental symptoms in chorea are in-
dicative of feebleness from the very first, while in multiple

* Notes on the Physiology and Pathology of the Nervous System, with refer-
ence to Clinical Medicine, New York, 1870, p. 11.
19

290

DISEASES OF THE BRAIN.

cerebral sclerosis imbecility supervenes late in the course of
the disorder. In chorea there are no vertigo, pain in the
head, or other evidences of congestion, while in the disease
under notice these are among the very earliest symptoms.
In chorea there is no actual tremor, but the disorderly
movements are more extensive and irregular than in multi-
ple cerebral sclerosis ; neither is there festination or bending
of the body forward.

Tremor is sometimes met with after cerebral haemor-
rhage or other cause producing hemiplegia, but in such
cases the clinical history, and the fact that the trembling
comes on after the paralysis, will suffice to render the diag-
nosis sure.

Prognosis. — The prospect of recovery is always unfavor-
able, but not, I am induced to think, absolutely hopeless if
the patient be seen sufficientl}'- early in the course of the
disease and submitted to proper medical treatment. The
probability of an arrest of the onward tendency is by no
means small under like circumstances. Still, in the great
majority of cases, all means fail, and the affection gradually
and persistently goes on to its termination, death.

Morbid Anatomy. — The membranes of the brain are some-
times opaque in patches and occasionally contain an abnor-
mal amount of serous fluid. The cerebral convolutions are
occasionally flattened, and the gray substance is thinner than
in the normal condition. It may also be changed in color,
being pale, and scarcely, according to Jaccoud, to be distin-
guished from the white substance.

On cutting into the tissue of the hemispheres, plates or
nodules of hardened matter are found scattered throuo^hout
its extent. These are well defined and vary in size from
that of a cherry-stone to that of a small walnut. In the
only case in which I have had the opportunity of making a
post-mortem examination, they were confined entirely to the
white substance of, the hemispheres. Their color is white
or grayish- white, and they are of varying degrees of consist-

MULTIPLE CEREBRAL SCLEROSIS.

291

ency from that of liard-boiled white of egg to that of car-
tilage.

Examined with the microscope, they are seen to consist
of the neuroglia, which, to a great extent, has taken the
place of the nervous tissue, and of the debris of this latter in
the forms of fibres, nucleated cells, and free nuclei. They
are formed, therefore, by the hypertrophy of the connective
tissue of the brain at the expense of the nervous tissue
proper.

Sometimes there are very few of these deposits — indeed,
there may only be one — and at others they are present in
large numbers. In the case examined by myself there were
seven in the left hemisphere and eleven in the right, of sizes
varying as previously stated.

They may be found in other parts of the cerebral mass
besides the hemispheres, though in the form under con-
sideration these are their most prominent and constant
seats. Thus, they may exist in the hemispheres and in
the medulla oblongata, the pons Varolii, and the cere-
bellum, at the same time. When they occupy, likewise,
the spinal cord, another disease is produced which differs
anatomically and pathologically from multiple cerebral
sclerosis.

Sometimes large numbers of amyloid corpuscles are met
with, but their presence is not constant.

Pathology. — The first question to be considered under
this head relates to the existence of multiple cerebral scle-
rosis as an independent affection — that is, without lesions of
like character being at the same time produced in the spinal
cord.

The weight of authority is probably against the view
expressed in this chapter, and, as I have, so far as I know,
made the first attempt to identify a certain group of symp-
toms with multiple sclerosis limited to the cerebral ganglia,
I am the more desirous to place the reasons by which I have
been actuated before the reader.

292

DISEASES OF THE BRAIN.

Andral/ under the designation of partial induration of
tlie brain, describes the morbid anatomy of an affection
which is probably the same as that under present considera-
tion, although his account of it is by no means full or pre-
cise.

Valentiner," citing a number of cases observed by him-
self and Frerichs, details one in which the lesions were lim-
ited to the brain, and in which the symptoms were similar
to those I have specified in this chapter.

Jaccoud declares that certain cases establish the possi-
bility of sclerosis limited to the encephalon. In a note he
refers to several writers who have stated the parts affected,
in some of which, however, the spinal cord was also involved.
In the following it appears to have been restricted to the
brain :

Stcehr, hemispheres corpora mamillaria ; Dumville, pro-
tuberance medulla oblongata and corpora olivaria; Pool,
hemispheres centrum ovale ; Cruveilhier, anterior face of
the medulla oblongata, protuberance, cerebral peduncles,
corpus callosum, walls of the lateral ventricles, and the ori-
gins of the pneumogastric glosso-pharyngeal and hypoglossal
nerves ; Duplay, hemispheres, particularly in the vicinity of
the ventricles, optic thalami, and corpora striata ; Yan
Camp, protuberance ; Obertirapfler, hemispheres ; Barthez
and Rilliet, hemispheres, particularly one convolution ; Cohn,
hemispheres in two cases ; Gunsburg, hemisphere, gray sub-
stance of the convolutions; Yalentiner-Frerichs, cerebellar
peduncles, corpora olivaria, protuberance, and medulla ob-
longata; Meynert, cerebellum and protuberance.'

Bourneville and Guerard,* while asserting that the exist-

' Preces d'Anatomie Pathologique, tome ii., 2' Partie, Paris, 1829, p. 810.

* Uber die Sklerose des Gehirns und Riickenmarks. Deutsche Klinic, B.
xiv., 1856.

2 I quote this note from Jaccoud, without vouching for its correctness, as,
from the fact that he does not cite the works in which the details are to be
found, I have not been able to verify his statements.

* De la Sclerose en Plaques Disseminees, Paris, 1869. Analyzed by Dr. E.

MULTIPLE CEREBRAL SCLEROSIS.

293

ence of multiple cerebral sclerosis as a separate and distinct
affection rests on only one case — that of Valentiner — winch
they further declare was probably imperfectly reported, ad-
mit that the cerebral form may be regarded as established.
But none of the authors who have referred to it identify a
form of paralysis agitans with a lesion characterized by the
presence of bodies of sclerosed tissue in the brain, and espe-
cially in the hemispheres. Thus, Dr. Clymer expresses the
opinion that, excluding the tremor, which may accompany
hemiplegia and certain other disorders of which it is an alto-
gether secondary phenomenon, there are but two varieties of
paralysis agitans : 1. That which results from multiple (dis-
seminated) sclerosis, affecting the encephalon and spinal cord ;
and, 2. A purely functional disorder, first fully described by
Parkinson.' 'Now, in my opinion, Parkinson has described
two very distinct affections under the name of paralysis agi-
tans. One of these is certainly functional so far as this ; that
the tremor shows no disposition to extend to distant parts of
the body, that it is the only symptom present, that no lesion
has been discovered, and that it is readily cured ; the other
is characterized by the phenomena which I have detailed in
this chapter, and which, though imperfectly described by
other authors, have either been confounded with multiple
cerebro-spinal sclerosis, or regarded as constituting an ag-
gravated form of the functional disorder. My views of its
true pathology have been formed from careful observation
of the course of the disease in nine cases, in one of which
I was enabled to make a post-mortem examination.

P. B., male, aged sixty-live, formerly a drummer in the
array, and latterly an instructor of buglers, came under my
observation at Ceboleta, New Mexico, in the winter of 1849-

C. Seguin in Archives de Physiologie, etc. No. 4, Juillet et Aout, 1870, p. 624,
ei seq.

' Essay on the Shaking-Palsy, London, 1817. I have not been able to find a
copy of this work in New York, and have for several years been unsuccessfully
trying to obtain it. My citations from it are therefore second-hand.

294

DISEASES OF THE BRAIN.

'50. While milking a cow, one evening, lie suddenly ex
perienced a severe pain in his head, which lasted only a few
seconds. He soon afterward had an epileptic paroxysm,
during which he bit his tongue severely. He had no other
fit, so far as was known, but the pain in the head recurred
at different times, never, however, lasting longer than a min-
ute or two.

ITo other symptom appeared for several weeks, and then
he experienced severe darting pains in the arms, and soon
afterward the left hand began to shake. On examination I
found the tremor limited entirely to the extensor communis
digitorum, and that the motion was entirely in the line of
extension and flexion. Little by little the other muscles of
the forearm became involved, and then the disorder extend-
ed upward, affecting the biceps coraco-brachialis triceps, del-
toid, and the muscles of the shoulder generally. The arm
was much weaker than the other, although he was left-
handed.

In about three months after first noticing the tremor in
the left hand, the left foot began to shake, and, as in the first
instance, the agitation gradually extended upward, until, so
far as I could see, all the muscles of the extremity were in-
volved.

He now complained of numbness in the ends of the
fingers of the affected extremity, and this slowly ex-
tended to the whole arm. The sensibility of the leg re-
mained intact.

!N'ext the right arm went through a similar sequence of
phenomena, then the right leg, and finally the head.

There was no decided tendency to forward impulsion till
both legs were involved, though there was difiiculty in main-
taining the erect posture, and the body was inclined forward
before either inferior extremity became affected. But, with
the accession of tremor in both lower limbs, a marked dispo-
sition to trot and a corresponding difficulty of walking
slowly made their appearance.

MULTIPLE CEREBRAL SCLEROSIS.

295

For over a year the tremor ceased as soon as the patient
went to sleep, and it generally became less troublesome as
soon as he lay down and tried to sleep. But at last it con-
tinned night and day, and thus apparently hastened the ter-
mination of the disease, for he lost strength rapidly from de-
privation of sleep. This debility was still further increased
by innutrition from improper food, it being impossible,
in the then state of the country, to get any fresh vege-
tables.

During the whole period from the occurrence of the first
paroxysm of pain, there was a gradual but marked failure
of the mental powers, until a condition of very decided
imbecility was reached. Death finally took place about
two years and one month after the epileptic fit, which
occurred on the same day with the first pain felt in the
head.

I made the post-mortem examination with great care,
but without any clearly-preconceived idea of what I should
find, except that I expected to discover lesions of some kind
in the brain and spinal cord. On removing the calvarium,
the membranes covering the surface of the hemispheres were
found to be healthy. I removed the entire brain from the
skull, and carefully examined the base. There was no ap-
preciable lesion of any kind. No tumor, no induration, no
softening of any of the ganglia. The membranes were dis-
sected off", and the convolutions on the superior surface were,
I thought, less distinctly marked than was normal. I then
cut through the right hemisphere horizontally an inch from
the surface, and was sm'prised to find the course of the scal-
pel resisted by a hard body. This I discovered to be a mass
of dense tissue one inch and a quarter long, half an inch
wide, and about half an inch thick. I then very thoroughly
examined the hemisphere, not allowing any part of it
to escape observation, and discovered eleven of these no-
dules of variable size — the smallest as large as a cherry-
stone, the largest about the size of a walnut — in the white

296

DISEASES OF THE BRAIN.

substance. In the left liemisphere I found seven similar
masses.

There were none in the peduncles, in the optic thalami,
in the corpora striata, in the medulla oblongata, pons Yarolii,
cerebellum, or any other part of the encephalic mass.

I then examined the spinal cord in like manner, making
several hundred sections of it, but found no alteration any-
where. It was perfectly healthy in every respect, neither
congested, softened, nor indurated in any part of its ex-
tent.

The sclerosed bodies were, many of them, dense and as
hard as cartilage, others were like hard-boiled white of egg,
and others like cheese. No microscopical examination was
made.

In this case the lesions were entirely limited to the hemi-
spheres, a circumstance which I can well believe is not com-
mon— other ganglia of the brain generally participating
and giving rise to corresponding modifications of, or addi-
tions to, the symptoms.

Thus, when the medulla oblongata is involved, there is
diiBculty of swallowing and implication of the muscles of
respiration ; when the pons Yarolii is affected, we have among
other symptoms facial paralysis ; when the corpora striata,
more intense paralysis ; when the optic thalami, derangement
of vision and perhaps of hearing ; when the crura cerebri,
various unilateral convulsive movements and participation
of the muscles supplied by the third pair of nerves ; and
when the cerebellum, especially the crura, the tendency to
go backward instead of forward ; and so on with the other
important parts of the encephalic mass.

Other relations connected with the pathology will be
considered when the subjects of multiple cerebro-spinal scle-
rosis, and wliat, for want of a better name, may be called
paralysis agitans, are reached.

Treatment. — To detail all the various methods which
have been employed in the treatment of the group of symp-

MULTIPLE CEREBRAL SCLEROSIS.

297

toms wliicli I have classed together as multiple cerebral
sclerosis mainly affecting the hemispheres, would be a fruit-
less piece of labor. Many of the cases of cure which have
been reported were not instances of the disease now under
notice, but of the milder, and, so far as we know, functional
disorder ; and, therefore, it would be useless to adduce them
as guides in the present connection. I shall therefore con-
fine my remarks to the results of my own experience.

I am very sure that the condition of the patient is gen-
erally improved by the simultaneous administration of the
chloride of barium and hyoscyamus. The former may be
employed according to the formula given in the immediately
preceding chapter ; that is, in doses of a grain three times
a day ; the other in the form of the tincture, in doses of
from one to two drachms morning, noon, and night. Care
should be taken that the latter preparation be fresh and
properly made. As sold in the apothecaries' shops, it is
often inert.

By these two remedies alone, the tremor is often mark-
edly diminished, and the paralysis and other disorders of
motility and sensibility greatly lessened.

Thus, in the case of a distinguished gentleman, a Sena-
tor of the United States, who consulted me in the spring
of 1870 for what was designated shaking-palsy, but in whom
I diagnosticated the disease under consideration, amendment
was perceived from the very first day of the treatment.
The tremor and paralysis diminished, the mind became
stronger and more able to endure exertion, and the physical
strength much increased. He was soon able to write and
to attend to his official duties, and he has continued in his
advanced stage of improvement to the present date. He
still, however, takes his medicines, and will probably be
obliged to do so for a long time yet.

In another case — that of a gentleman living in the in-
terior of this ^tate — ^no means have been so successful in
improving the general health, and arresting the progress of

298

DISEASES OF THE BRAIN.

the disease, as the chloride of barium and tincture of hyos-
cyamus. I have given these remedies alone or in conjunc-
tion with others in six cases, and never without a decidedly
favorable effect.

Electricity is, however, a powerful adjunct, and I always
employ it when the opportunity exists for so doing. The
primary current, from fifteen of Smee's cells, should be
passed through the brain antero-posteriorly and laterally,
as previously described, and the sympathetic nerve should
likewise be acted upon by a current of similar intensity.

The tremulous muscles should also be subjected to the
influence of a primary current of low tension. I am not
sure that it makes any difi'erence in which direction the
current be passed, but it is important that it should not be
so intense as to cause any considerable pain.

For the paralysis the induced current — not too strong —
is to be recommended, and for any contractions that may
be present it is the preferable form to use.

A gentleman, over sixty years of age, from Tennessee,
consulted me in September, 1870, for tremor associated
with paralysis. His physician, Dr. W. W. Yandell, came
with him, and gave me much valuable information in regard
to the progress of the disease. In the first place, there had
been, several years previously, symptoms of a disordered
cerebral circulation, indicated by pain and vertigo. Soon
afterward tremor supervened in the left hand, and gradually
extended to both limbs of that side. There were also paraly-
sis and loss of sensibility. When he came under my notice,
the upper extremity was more afiected than the lower ; con-
tractions had taken place, and the fingers were strongly
pressed against the palm of the hand, the hand was bent on
the forarm, and the elbow was flexed to its utmost extent.
The limb was somewhat atrophied, but electro-muscular
contractility was not sensibl}'' impaired.

The voice was exceedingly weak, but there was no paraly-
sis of the tongue or facial muscles, and, though the patient

MULTIPLE CEREBRAL SCLEROSIS.

299

could not speak above a whisper, every word was articulated
distinctly, and was appropriately used. The body was greatly
bent forward, the attitude being that of a person ascending
a steep hill, and there was decided festination. The tremor
and paralysis were much more marked on the left side than
the right, and the agitation was altogether independent of
voluntary movements.

The mind, except as regarded the memory, was not essen-
tially impaired, and the sight and hearing were unaffected
by the disease. There had never been any convulsive at-
tack or loss of consciousness, and the course of the disease
had been extremely gradual. Ophthalmoscopic examina-
tion revealed nothing beyond an anaBmic condition of the
retinae and choroids.

I diagnosticated multiple cerebral sclerosis mainly affect-
ing the hemispheres, but probably involving also the right
corpus striatum, and I prescribed the chloride of barium,
tincture of hyoscyamus, and electricity. He remained in
New York a few days, and then returned to his home with
the tremor abated, the contractions partially overcome, the
muscles improved in strength, and the tendency to festina-
tion lessened.

A month afterward Dr. Yandell, who had continued the
treatment, wrote me, of the patient, that the improvement
was more decided than his most sanguine friends had anti-
cipated, and still continued ; that the agitation was scarcely
perceptible ; that he could more than half extend the fingers
of the left hand, could straighten the wrist and elbow, and
could lift a chair, or put on his hat, with the right hand.
From what I liave since ascertained, he bids fair to recover
entirely.

If the general health be materially impaired, cod-liver
oil, iron, and strychnia, may be administered with advan-
tage.

The food should always be highly nutritious, and a glass
or two of wine, if not particularly contraindicated, may be

300

DISEASES OF THE BRAIN.

taken daily with advantage. Passive exercise in the open
air is always beneficial, but excessive walking or strong
muscular exertion of any kind should be carefully avoided.
Emotional excitement or mental labor must be rigidly
avoided.

Under the treatment thus indicated, the patient may at
least be relieved of a great deal of his suflfering.

CHAPTER XIY.

TUMOES OF THE BRAIN.

Though tumors of the brain differ greatly in charac-
ter, thej all, when they are accompanied by any notable
symptoms, present many features in common. It will,
therefore, be convenient to consider them under one head,
and point out their differences when the morbid anatomy
and pathology are discussed.

Symptoms. — It is possible for a person to have a tumor of
the brain as large as an orange, and present no symptoms
of it during life. One such case came under my observation
several years ago, and many others are on record. In the
instance referred to, the patient, a teamster, was twice shot
in a quarrel, one ball grazed the skull, ploughing up the
right parietal bone for the extent of an inch ; the other
entered the left breast, wounding the heart. Death ensued
almost instantly. The brain was examined, and a tumor of
an elliptical form, two inches in its long diameter, and one
and three-quarters in its short diameter, was found, involv-
ing the white substance of the left posterior lobe. The char-
acter was that which Yirchow has since called gliomatous,
and contained no nervous tissue.

Again, it sometimes happens that tumors of large size
exist in the brain, and produce no symptoms till a few days
before death. Then very violent manifestations ensue, and
the patient dies convulsed or comatose. And it is always
the case that the symptoms are entirely different, as one or
other part of the brain is involved, or the tumor is large or

302

DISEASES OF THE BRAIN.

small. Thus, we know very well that a morbid growth,
seated in the pons Yarolii, will cause very diverse symptoms
from those produced by a similar formation in one of the
anterior lobes of the hemispheres. We may say, in general
terms, that tumors situated in the medulla oblongata, the
pons, the optic thalami, the corpora striata, the crura cere-
bri, the cerebellum, and the convex surface of the hemi-
spheres, give rise to more decided manifestations than when
the white substance of the hemispheres is the seat.

Pain is probably the first symptom which attracts atten-
tion. It is generally confined to a definite region of the
head corresponding to the location of the disease, but this is
not always the case. It may be either a dull ache, lasting
the greater portion of the day, or a sharp, lancinating par-
oxysm, which ensues but for a few moments and recurs
frequently. As the morbid process goes on, the cephalalgia
becomes more severe, and finally reaches a stage of great in-
tensity. So great is the suffering that the patient cries out
with the agony, and in a case under my observation suicide
was attempted. Mental excitement, physical exertion,
noises, and bright lights, aggravate the pain.

The special senses rarely escape. The sight is among
the first to suffer derangement, and vision may be irretriev-
ably lost from pressure exerted upon the optic nerve, or
through congestion of the retina and choroid and consequent
disorganization of these structures. The eyeball of the af-
fected side is often rendered more prominent than the other,
even when the tumor does not involve the orbit.

The hearing is also often affected, and the taste not un-
frequently perverted or lessened in acuteness.

Disorders of sensibility in various parts of the body are
common. These are either of the nature of anaesthesia or
hypersesthesia, and are usually experienced in the face or
extremities.

Yertigo is a very general symptom, and may be of all
degrees of intensity, sometimes preventing the patient stand-

TUMORS OF THE BRAIN.

303

ing, walking, or even sitting. It is often observed very
early in the course of the disease, and is frequently accom-
panied by nausea or vomiting.

The disorders of motility are shown either as paralysis or
convulsions. In several cases under my observation the loss
of muscular power was first exhibited in the muscles of the
eyeball and its appendages, causing external strabismus,
ptosis, and permanent dilatation of the pupil, from paraly-
sis of the third nerve, or internal strabismus from the lesion
involving the sixth nerve.

In a case now under my charge, the muscles supplied by
the right facial nerve are alone affected, and in another
the left side of the face and right side of the body are para-
lyzed. When there is paralysis, it is generally of the hemi-
plegic form, though occasionally it is paraplegic. Whatever
its form, it is almost always of slow progress. Paralysis
may be entirely absent. It is only a necessary attendant
when the tumor involves some part of the motor tract.

When the muscles concerned in articulation are impli-
cated, the speech is rendered indistinct, and some sounds
may be impossible of utterance, not from any defect in the
idea of language or of its expression, but simply from pare-
sis of the vocal organs.

Convulsions are other prominent symptoms, and they
may be among the initial phenomena. It is not at all un-
usual for the first evidence of intra- cranial disturbance to be
an epileptiform convulsion, and similar paroxysms may oc-
cur at intervals for many years. They may be general, or,
what is more common, limited to one side of the body.

Sometimes consciousness is not lost, but there are various
convulsive movements of the limbs, tonic or clonic in char-
acter. Occasionally these are confined to the muscles of the
face or eyeball.

Disturbances of equilibrium, manifested by tendency to
advance, to go backward, or to turn round to the right or
left, are sometimes present.

304

DISEASES OF THE BRAIN.

With these symptoms there are generally others not so
palpably connected with the morbid intra-cranial process.
Thus there may be disorders of the stomach, bowels, and
kidneys, and of the respiration and circulation, which add
much to the discomfort of the patient.

As to the intellectual faculties, it is not uncommon to
find that they do not become involved to any considerable
extent till a late period of the disease. Then the change is
usually a gradually-advancing imbecility.

Death takes place either by convulsions or coma, or a
combination of both. The following cases, which I select
from my note-book, are interesting in several relations :

J. H., male, aged thirty-seven, came under my obser-
vation January 15, 1856, at Fort Riley, in Kansas. A
few months before he had received an injury of the left hip
by being thrown from his horse, and was stunned for a few
minutes. A few days afterward, as he was lying in bed, he
suddenly became vertiginous, and at the same time had
noises in his ears and some pain not very definitely located.
He never had vertigo again, but the pain never left him
night or day for several weeks. It then suddenly ceased,
and did not recur till the morning of December 31st, when a
sharp twinge was experienced in the front of the head, and
he immediately saw every thing double. Ptosis and dilated
pupil of the left eye soon supervened, and the arm of the
right side became weaker. When I saw him the grasp of
his hand was very feeble, and the ocular troubles very
noticeable. The pain was almost constantly present, and
was of the most intense character. He said it seemed as if
a red-hot iron were being thrust through his brain.

He had come several miles to see me, and went home
after I had given him a palliative medicine. A few days
afterward a messenger came for me in great haste, with the
information that the patient was dying, and requesting my
attendance. On my arrival, I found that he had been dead
several hours, having had repeated severe convulsions. On

TUMORS OF THE BRAIN.

305

post-mortem examination, a tumor, spheroidal in shape, with
an average diameter of an inch and a quarter, was found
occupying the middle third of the inner surface of the left
middle lobe, so as to press on the left crus and third nerve.

The points of interest in this case are the sudden cessa-
tion of the pain and its recurrence simultaneously with the
paralysis of the third nerve, the slight paralysis of the body,
and the absence of convulsions till just before the fatal ter-
mination. The ptosis, diplopia, and dilatation of the pupil,
doubtless occurred at the very instant that the tumor en-
croached on the crus.

The history of the following case, which I saw in Sep-
tember, 1864, at the request of my friend Prof. Yan Buren,
I take from the report of Dr. F. 11. Otis,* under whose
immediate care the patient was :

Miss E., aged twenty-six, was of healthy parentage, and,
though of delicate organization, had enjoyed good health up
to February, 1861, when she received a fall on the ice, strik-
ing violently upon her elbow. She was not conscious of re-
ceiving any other injury at the time. At three a. m. of the
following day she awoke with an intense pain in the top of
her head, of a throbbing, lancinating character, which con-
tinued throughout the day. By night she obtained relief.
'No further effect from the fall was experienced until about
two weeks subsequently, when she discovered a small firm
circumscribed swelling on the crown of the head at the point
where the pain had previously been felt. This swelling,
which was painless, increased gradually, until, after a year,
it had attained the size of half a lemon. Soon after the ap-
pearance of the tumor. Miss E. began to suffer with severe
pain, confined chiefly to the vertex, of the same character as
that experienced immediately after the fall. This pain
would continue almost without cessation for two or three
weeks, after which for a like period she would be quite free
from it.

1 New York Medical Jourxal, vol. i., 1865, p. 26.
20

306

DISEASES OF THE BRAIN.

She had also occasional attacks of numbness, preceded by
great drowsiness, and a cold, creeping sensation, succeeded
by total loss of the power of motion, sometimes confined to
a single extremity, and at others involving the entire body.
These attacks usually came on at night, or after rest in a re-
cumbent position, and generally, though not invariably,
were precursors of severe headache. They were always fol-
lowed by great nervous prostration. At first rare, they in-
creased in frequency as the tumor enlarged, so that by Feb-
ruary, 1863, she was seldom free from them for more than
ten or twelve days, and the tumor had doubled in size within
the year. She now began to be much annoyed by tingling,
crawling sensations in lier face and through the head after
any unusual exertion in writing, reading, or singing, but
rode daily on horseback with apparent benefit. As time
passed, she had frequent dizzy turns, with nausea, and sud-
den flashes like electric shocks passing over the entire
body, lasting only for an instant, but leaving her much
prostrated. The headache, which was always of the most
agonizing description, came to be referred chiefly to the
tumor, though often associated with pain through the tem-
ples and other parts of the head. The muscles of the neck
sometimes became rigid, and the vision, as well as the sense
of taste and smell, often became very imperfect and con-
tinued so for weeks. Sometimes the power of speech would
be lost, but she always retained perfect consciousness. These
attacks rarely lasted more than an hour or two.

On the 23d of October, 1864, she was attacked with a
peritoneal inflammation, from the efiects of which she died
on the ninth day thereafter. Leaving out the details of the
post-mortem examination of other parts of the body, we find
that an incision was made across the vertex from ear to
ear, and the skin dissected from the tumor, at the apex of
which it was found to be firmly adherent. The calvarium
was then sawn in a line one inch above the orbital margin
around to the occipital protuberance; the hemispheres of

TUMORS OF THE BRAIN.

307

the cerebrum were then sliced, and the whole raised at the
same time.

On removing the two hemispheres, which were adhe-
rent above, a tmnor one and a quarter inch in thickness and
three inches in diameter, of a dull lemon-yellow color, a
little softer than the cerebral substance, and separated into
two lateral halves, was seen springing from the central sur-
face of the dura mater. This intra-cranial tumor had insin-
uated itself into the sulci between the convolutions, and the
dura mater could be traced between it and the bones. The
situation of the tumor, and the relation to the exterior
growth, are shown in the accompanying cut :

Fig. 10.

The microscopical examination by Dr. Gouley gave indi-
cations that both formations were encephaloid in character.

Similar cases to the foregoing have been reported by
Mr. Paget,' of London, and by the late Dr. Isaacs," of this

' Surgical Pathology, London, 1853, yol. ii., p. 221.

* Transactions of the Medical Society of the State of New York, 1859.

308

DISEASES OF THE BRAIN.

city. It will be noticed that, in the case just cited, there
were neither convulsions, paralysis, aneesthesia, mental de-
rangement, nor difficulties of speech. "When I saw the young
lady, not long before her death, there were no symptoms
present from which it could have been inferred that a tu-
mor occupied any part of the intra-cranial cavity.

I. R., a general officer of volunteers during the late war,
consulted me in the spring of 1870, through his brother, for
what was thought to be softening of the brain. The patient
was stout and well made, had no difficulty of speech, no de-
rangement of sensibility, and no paralysis of any part of the
body. His senses were remarkably acute. His memory,
however, was almost entirely gone, he had forgotten the
names of his children, did not even know what city he was
in, and could not tell me where he had. been just before
coming to see me. Besides this there was absolutely noth-
ing. His strength was enormous, and his grip one that I
shall not readily forget.

His previous history was that he had served arduously
through the war, and had, on being mustered out of service,
resumed his business as a lumber-merchant. ISTo syphilitic
taint could be discovered. Six months before I saw him ho
had been suddenly seized with an epileptiform paroxysm,
which was followed by agonizing pain in the head. A
second convulsion ensued in about a month afterward, the
pain continuing to be of the utmost severity, and almost
without intermission. There was a third attack, and then
the pain ceased ; but the failure of memory began to be
manifested from that moment, and had gradually been be-
coming more pronounced.

I diagnosticated a tumor involving mainly the white
substance of one of the hemispheres, situated probably in
the posterior lobe, and not affecting the motor tract, or the
course of any of the cranial nerves. My principal reasons
for not regarding the lesion as softening were the absence
of paralysis or even paresis, the integrity of all the special

TUMORS OF THE BRAIN.

309

senses, and the absolute perfection of articulation. At tlie
same time I regarded the matter as extremely doubtful, and
I cite the case here merely as one of interest in wbich the
difficulty was probably a tumor. The patient died during
the first week in January of the present year (1871), but I
have received no details of any post-mortem examination.

In May, 1870, I was requested by Dr. Hermann Knapp
to meet him in consultation in the case of a gentleman suf-
fering from a cerebral tumor. The morbid growth appar-
ently occupied the right anterior lobe of the brain, and in-
volved also the temporal region of the skull on the same
side. The sight of the right eye was destroyed, and that of
the left so much impaired that only strong lights or shadows
could be distinguished. The lymphatic glands of the neck
were very much enlarged.

The pain was most acute night and day, with scarcely
an intermission. The right arm was numb and paralytic,
but there was no absolute paralysis anywhere except in the
ocular muscles. The mind was intact, and there had never
been a convulsion.

Under the use of the iodide of potassium and the protio-
dide of mercury the swelling of the cranium diminished,
the swollen lymphatic glands were reduced, and the pain
almost entirely abolished. I saw him several times after-
ward, and, when I discontinued my visits, he was doing
wonderfully well. Since then I have lost sight of him.

There was no history of syphilis in this case.

The following account of a case, in which there was a
tumor of the cerebellum, I have from my friend Prof. Aus-
tin Flint, M. D. :

"In June, 1842, I was present, by invitation of Dr.
James P. White, of Buffalo, at the autopsy in the case of
W. P., aged about forty years. I noted at that time the
following brief account of the history as stated by Dr.
"White the attending physician :

" The illness was dated from the preceding February

310

DISEASES OF THE BRAIN.

(five months), but lie liad previously complained of pain in
the head, and lassitude. In February he had had chills,
which were at first attributed to malaria. Subsequently
vomiting was a prominent symptom ; it occurred in the
morning immediately after rising from bed. Cephalalgia
was a frequent, not a constant, symptom. He referred the
pain especially to the occiput. In April he left Buffalo to
visit friends in Kochester. He was prostrated by the jour-
ney, and, his condition now being alarming, he returned
home. ^Notwithstanding the treatment adopted, he grddu-
ally failed, and died June Yth,

" There had never been convulsions nor paralysis.

" Post-mortem Examination. — The body was consider-
ably emaciated. There was slight opacity of the arachnoid,
and in some situations a small quantity of serum was effused
beneath this membrane. The effusion within the ventricles
was somewhat greater than usual. With these exceptions
there were no morbid appearances, except in the cerebellum.
Here was a tumor of the size of an English walnut. It
was of fine consistence, and supposed to be tuberculous.
There was no appearance of inflammation or softening of the
cerebral substance around the tumor, which was situated in
the right lobe of the cerebellum.

" It was ascertained in this case that the venereal appe-
tite had been wanting for many months before death. I
recollect that Dr. White informed me at the time that ver-
tigo was a feature in this case, and that it induced unsteadi-
ness in the voluntary movements. Dr. White has since in-
formed me that his recollection is now distinct as regards
this point."

A very important paper on intra-cranial tumors is that
of my friend Prof. Eoberts Bartholow, M. D.,* of Cincinnati.
Dr. Bartholow has discussed the relations of symptoms to
lesions with great perspicuity and fulness.

1 Report on Intra-cranial Tumors ; their Symptomatology and Diagnosis,
with Illustrated Cases, Columbus, 1869.

TUMORS OF THE BRAIN.

311

This able observer divides the symptoms produced by-
cerebral tumors into two orders :

1. Those common to morbid growths or adventitious
products in general.

2. Those peculiar to tmnors in special situations.

In the first order are to be placed headache, vertigo, am-
aurosis, convulsions, and derangement of the intellectual
and reflective faculties ; in the second alterations of sensibili-
ty, disturbances of the special senses, disorders of motility,
vomiting, and urinary disorders.

Causes. — The causes of cerebral tumors are so intimately
connected with their character that a classification becomes
at once necessary. Following Jaccoud^ in this respect, I
shall divide them into four groups : the vascular, the par-
asitic, the diathetic or constitutional, and the accidental.
Even with this division we shall find that our knowledge of
their etiology is not extensive.

Vascular tumors are aneurisms of the cerebral arteries.
The term does not include the capillary aneurisms of Bour-
chard and Charcot, referred to under the head of cerebral
haemorrhage, but applies only to dilatations of the larger ar-
teries. According to Gouguenheim,^ they are more common
between the ages of fifty and sixty than at other periods of
life, though cases were met with under the age of puberty.
Tables given by Durand ' are to the same efiect, as is like-
wise the experience of Lebert,* Gull,* and others. This is
what might be expected from the known proclivity of the
arteries to disease after the age of fifty.

Sex appears to exert but little influence, though aneu-
risms of the cerebral arteries seem to be somewhat more fre-
quent with men than women.

1 Op. cit., page 247.

^ Des Tumeurs anevrysmales des art^res du Cerveau. These de Paris, 1866,
p. 12.

* Des anevrysmes du Cerveau. These de Paris, 1868, p. 87.

* Klinische Wochenschrift, Berlin, Nos. 20 to 42, 1866.

5 Guy's Hospital Reports, tljird series, vol. v., 1859, p. 281, ei seq.

312

DISEASES OF THE BRAIN.

As exciting causes, blows on tlie head, falls, sudden and
great physical exertion, intense emotion, or mental labor,
embolism, and concentric hypertroplij of the heart, are to
be mentioned.

Parasitic tumors are caused by the migration of the em-
bryos of the cysticercus and echinococcus from other parts of
the body.

Diathetic tumors are either cancerous, tuberculous, or
syphilitic in character. The first named are more common
during the adult period of life than any other, though they
are met with at all ages. Although women are more sub-
ject to some forms of cancerous tumors than men, yet in the
brain they are far more common in the male sex. Of forty-
eight cases studied by Lebert, cancer of the brain was primary
in forty-five, that is, made its first appearance in this organ.

Ogle,' of twenty-five cases of cerebral cancer, found that
in thirteen the disease was confined to the brain, while,
on the other hand, contrary to the generally received opin-
ion. Dr. Mackenzie Bacon ^ found but ten primary cases out
of seventy-three.

There is no doubt that cancer of the brain is sometimes
the result of traumatic cause.

Txiherculous tumors of the brain are generally met with
in young childi'en, though they do occur, as in the case re-
lated by Dr. Flint just cited, in adults. They are almost
always secondary to similar products in the lungs.

Syphilitic tumors are, of course, the result of the sj^hi-
litic infection of the system.

Accidental tumors may be caused by injuries, as was
probably the case in one of the instances cited. Jaccoud,
however, expresses the opinion that such an apparent relation
is purely accidental, and that all we know of their etiology
is that they are more common after the age of forty than be-
fore that period.

' British and Foreign Medico-Chirurgical Review, July, 1865, p. 223.
* On Primary Cancer of the Brain, London, 1865.

TUMORS OF THE BRAIN.

313

Diagnosis. — The diagnosis of cerebral tumors is sometimes
almost self-evident, in others it is equally impossible. This
difference is due, not only to the various situations they
may occupy, but also to their diverse nature.

The presence of severe pain in the head for a long time
is of itself some indication of the existence of a tumor if it
is unaccompanied by febrile excitement. Epileptiform con-
vulsions, occurring after the age of forty, should excite sus-
picion that their cause is to be found in a morbid growth of
some kind. The character of the convulsive seizures will
aid us in forming an opinion of their etiology. When pro-
duced by a tumor they are generally unilateral, the loss of
consciousness is not so complete, and there is rarely subse-
quent stupor. The diagnosis from epilepsy is rendered
more evident by the fact that, in tumor, the convulsions are
seldom accompanied by mental weakness, and never by
periods of active unconsciousness. From softening the dis-
tinction can be made without much difficulty in the majori-
ty of cases. The acute pain, the integrity of the mind, and
the absence of general paresis, will usually suffice. But
sometimes the discrimination cannot be made, for there are
cases of tumors in which there is very little pain, in which
the mind is involved, and in which the paralysis is not very
strongly marked.

The occurrence of very limited paralysis points to the
existence of a tumor, rather than any other affection. A
gentleman is now under my care, who, several years ago,
had a cerebral haemorrhage, from which he was rendered
hemiplegic. He regained to a great extent his mental and
physical powers, but a few days ago suddenly had diplopia
from paralysis of the external rectus muscle of the left eye,
by which internal strabismus was produced. As yet there
have been no other head-symptoms except vertigo, with
which he has suffered a great deal in the last two years, and
which was excessive when the diplopia appeared. In other
respects the health is good, and the mind gives no evidence

DISEASES OF THE BRAIN.

of being affected. The paralysis of tlie external rectus is on
the same side with the general hemiplegia.

In my opinion, though I express it, of course, without
positiveness, there is an aneurismal tumor pressing upon the
sixth nerve after its emergence from the medulla oblongata,
and probably affecting the left internal carotid artery. If
this view be correct, other symptoms will certainly arise ere
long. These will probably consist in the more extensive
implication of cranial nerves, and in the supervention of
hemiplegia.

The diagnosis of the character of the tumor is of interest,
and sometimes of importance with a view to the prognosis.

Aneurismal tumors are more common in persons of ad-
vanced age than in the young, they are more frequently ac-
companied by vertigo, and they are more generally indicated
by paralysis of one or more of the cranial nerves. The men-
tal symptoms are not often marked.

Parasitical tumors usually first manifest themselves by
the occurrence of epileptiform convulsions, and the mental
faculties do not long remain unaffected, for the reason that
such products are more commonly seated in the gray sub-
stance of the brain than in the white tissue or the ganglia at
the base. As these latter generally escape, troubles of mo-
tility are rare. Diathetic tumors are more easily recognized
than any others, for the reason that we have other evidence
of the existence of constitutional infection in the great major-
ity of cases. As regards cancer, however, this aid is not gen-
erally afforded, the affection being usually primary, and not
producing the ordinary indications of the cancerous cachexia.
But, as in the case cited in full, and the others referred to,
the existence of an external tumor is some indication, in con-
nection with head-symptoms, that there is a corresponding
growth within the cranium.

Tubercle may be suspected in cases presenting the symp-
toms of cerebral tumor, when there are indications of simi-
lar deposits in the lungs or other parts of the body, when

TUMORS OF THE BRAIN.

315

the subject exhibits evidence of possessing the tuberculous
diathesis, or when the history shows hereditary tendency.

In a patient presenting the symptoms of a tumor of the
brain, its nature may safely be considered syphilitic, if, in
addition, his clinical history shows that he is tainted with
syphilis, or has, at some former period, suffered from it.

In regard to accidental tumors or those of various ana-
tomical characteristics, there is not much to be said of their
diagnosis. There are no means by which one species can
be distinguished fi-om another, and no positive indications
which can enable us to discriminate them from other tu-
mors, except by the way of exclusion.

Prognosis. — Cerebral tumors uniformly lead to a fatal re-
sult, except they be syphilitic in character. In these latter
there is a very considerable prospect of recovery if the prop-
er medical treatment be adopted.

Morbid Anatomy and Pathology. — Vascular Tumors. —
The most common seat of cerebral aneurisms is the basilar
artery, and they are larger here than when any other vessel
is affected. Gouguenheim ' gives the following table, based
upon sixty-eight cases :

Cerebral aneurisms do not differ in any essential particu-
lar from similar formations in other parts of the body. They
are, however, smaller, rarely being as large as a walnut, and

Basilar

Middle cerebral

Internal carotids

Anterior cerebral

Posterior communicating

Cerebellar

Anterior communicating .

Posterior cerebral

Middle meningeal

Arterio-venous

17 cases.

14 "

12 "

8 "

5 "

4 "

2 "

3 "
2 "
2 "

1 Op. cit., page 21.

316

DISEASES OF THE BEAIN.

generally ranging in size from that of a cherry-stone to that
of an almond.

Lebert ascertained that they were more frequently met
with in the arteries of the left side of the brain than in those
of the right. Gouguenheim confirms this observation. Thus
of forty-one cases in which the side was determined, twenty-
seven were on the left, and fourteen on the right. This dif-
ference is doubtless in part at least due to the fact that one
of the causes of cerebral aneurisms, embolus, is more common
on the left side than on the right. In a very interesting
paper, Prof. "W. E.. Smith * calls attention to the fact that
aneurisms of the encephalic arteries may be thus produced.
The following figure, which I take from his memoir, gives
an excellent illustration of such an aneurism in the left mid-
dle cerebral artery :

Fig. 11. 2

In regard to the post-mortem examination of the patient,
from whom the preparation was taken, Prof. Smith says:

" Upon tracing the left middle cerebral artery into the
fissure of Sylvius, it was found to be obstructed (just where
it branches into twigs surrounding the island of Reil) by a
plug of fibrine of a yellowish color and oblong form, fully a
quarter of an inch in length and about the eighth of an inch

J Cerebral Aneurism. Reports of the Dublin Pathological Society. Dublin
Quarterly Journal of Medical Science, November, 1870, p. 443.

^ The drawing shows the position of the aneurism reversed to the right side.

TUMORS OF THE BRAIN.

317

in breadth. At the seat of obstruction the vessel was di-
lated into an oblong tumor half an inch in length and a
quarter of an inch broad, the space intervening between the
original plug and the arterial tunics being occupied by co-
agulated blood."

The theory sustained by Prof. Smith was, as he freely
states, first proposed by Dr. Senhouse Kikes * in the paper to
which I have already referred under the head of embolism.

The idea was formerly very generally entertained, that
cerebral aneurisms were always true, that is, caused by the
uniform dilatation of all the coats of the artery. Hodgson
sustained this view on the ground that the tunics of the en-
cephalic arteries were of such extreme tenuity that they
readily dilated, and Albers,' Crisp,* Gull,^ and others, held
similar opinions, but the recognition of the fact that the
arteries of the brain are peculiarly subject to disease in per-
sons advanced in age, and the researches of Lebert, Yir-
chow, and Kolliker, go to show that such a view is errone-
ous. Three other kinds are known to exist, the mixed ex-
ternal in which the interior and middle coats are ruptured
and the sac is formed by the external coat ; the dissecting, in
which the internal tunic is ruptured and the blood is to a
certain extent forced between the layers of the middle tunic ;
and the arterio-venous. This latter is seated in the caver-
nus sinus, and is produced by the rupture of a small carotid
aneurism, or it is the result of wound or injury.

Aneurismal tumors may cause death either by the press-
ure which they exert on important parts of the brain or by
the giving way of the sac and the consequent extravasation
of blood, producing pressure and disorganization.

Parasitio tumors are of two kinds, those produced by the

' Medico-Chirurgical Transactions, vol. xxxv., p. 852.
2 A Treatise on the Diseases of Arteries and Veins, London, 1815
2 Memoire sur les Anevrysmes du Cerveau et ses Meninges, Bonn, 1836.
* A Treatise on the Structure, Diseases, and Injuries of the Blood-vessels,
London, 184Y.

5 Guy's Hospital Reports, 1857.

318

DISEASES OF THE BRAIN.

cysticercTis and those caused by the echinococcus or hydatids.
The former are small, scarcely ever being larger than a small
bean. They are rarely encysted, as in other parts of the
body, but are in close apposition with the brain-substance.
They are generally met with in numbers ranging from ten
to twenty. Cruveilhier ' reports a case in which there were
over one hundred.

They are found in all parts of the cerebrum and cerebel-
lum ; fifty of those discovered by Cruveilhier, in the case
just cited, were in the cerebellum. Generally they are
near the surface of the brain — often in the pia mater, in
which situation they press upon the gray matter, and often
in this latter substance. When situated in the ventricles,
there is less impediment to the growth of the parasite, and
hence it may become developed into a more or less perfect
tape-worm.

Cobbold " states that there are about one hundred cases
on record of cysticerci being found in the brain after death.
Of these, Griesinger ' reports between fifty and sixty.

Echinococci, or hydatids, though much larger than the
foregoing-described parasites, are less numerous. Gener-
ally there is only one, and rarely are there two cysts. Each
cyst may contain a single hydatid, as is usually the case, or
there may be more in difierent stages of growth. In size,
the cysts vary from that of a marble to that of an orange,
and consist of a vascular membrane enclosing the parasite.

Of one hundred and thirty-three cases occurring in the
human subject and analyzed by Cobbold, sixteen were situ-
ated in the brain. All were of course fatal.

Both of these species of parasitical tumors may be pri-
mary, or they may be accompanied by similar growths in
other parts of the body.

* Anat. Pathol. G611., t. ii., p. 83, Paris, 1852.

* Entozoa : An Introduction to the Study of Hehninthology, with Reference
more particularly to the Internal Parasites of Man, London, 1864.

2 Cysticerken und ihre Diagnose, Archiv der Heilkunde, 1862.

TUMORS OF THE BRAIN.

319

Diathetic tumors are either cancerous, tuberculous, or
syphilitic*

Cancer may affect any part of the brain, though it more
generally attacks the hemispheres, the cerebellum, the optic
thalami, the corpus striatum, or the pons Varolii. It may
begin in the bones of the cranium, in the membranes, or in
the brain itself. A common seat is the orbit. According
to Dr. Mackenzie Bacon, of seventy-three cases of brain-
tumors occurring in the London hospitals during the period
from 1854 to 1863, ten were cancerous. Ladame,* of three
hundred and thirty-nine cases of cerebral tumors, collected
from various sources, found that sixty-seven were cancerous.

The dimensions of cancerous tumors are very variable.
Generally they do not much exceed the size of an English
walnut, though they may be twice as large.

Either variety of cancer, encephaloid, scirrhous, or col-
loid, may have its seat in the brain. Primitive cancer is
usually single ; secondary, multiple. In a case reported by
Dr. Webber,' of Boston, in which there was a preexisting
cancerous tumor of the vagina, the brain was found to con-
tain several deposits of cancerous growths — one quite
large, situated in the left hemisphere, and two in the cere-
bellum.

Ogle * has shown that the brain-substance surrounding
the cancerous growth undergoes softening. Frequently it
13 not changed at all.

The tumor itself does not often undergo softening, but a
kind of fatty degeneration and atrophy occur, and the tissue
becomes hard and compact, with no traces of blood-vessels
remaining.

Tubercular tumors may be either single or multiple. In
the former case, they are often as large as a cherry ; in the

» Op. cit.

' Symptomatologie und Diagnostik der Hirngeschwiilste, Wiirzburg, 1865.
' Journal of Psychological Mkdicine, vol. iv., 1870, p. 669.
< Journal of Mental Science, 1864, p. 229.

320

DISEASES OF THE BRAIN.

latter, tliej may be as small as a grain of wheat. Yery
large tubercular tumors result from the fusion of two or more
smaller ones. They are generally seated in the hemispheres
or cerebellum, though the other parts of the encephalon are
not exempt. They are the most frequently met with of
all the forms of cerebral tumors.

Syphilitic tumors are in general seated in the mem-
branes, or in these and the gray matter. They are very
rarely entirely confined to the substance of the brain, and
are never encysted. They are, therefore, not distinctly cir-
cumscribed, but the elements of which they are composed
are infiltrated into the surrounding brain-tissue. In size
they vary, rarely being as large as a walnut. Histologically
they consist of nuclei and cells. The former contain nucle-
oli and occupy the periphery of the tumor, while the cells
are found mainly in the centre. Syphilitic tumors are or-
dinarily accompanied by like growths in other parts of the
body, especially the lungs and liver.

Accidental Tumors. — Under this head are included all
formations not diathetic or vascular. Among them are the
fibro-jplastic tumors, which may attain to the size of an
orange and which are generally growths from the dura
mater at the external part of the base of the cranium. They
are composed of fusiform cells, nuclei, and blood-vessels.
They are of variable consistence, sometimes being almost
fluid, and at others gelatiniform in character.

Under the name of gliomata, Yirchow described a cere-
bral growth due to an abnormal development of the neuro-
glia or connective tissue of the brain. They are more gen-
erally found in the posterior cerebral lobes, and may attain
to the size of an orange. Usually there is but one. There
are two kinds of these tumors, one soft, being about the con-
sistence of the brain-substance, the other much harder.
They consist of cells and nuclei, but never contain any of the
nervous elements. Cholesteatomata, sometimes called pearly
tumors, may arise from the cranial bones, from the mem-

TUMORS OF .THE BRAIN.

321

branes, or from the brain itself. They rarely attain to the
size of a walnut, and are generally very much smaller. His-
tologically they consist of a limiting membrane of extreme
tenuity, the contents of which are disposed in concentric
layers. These strata are epidermic cells which have under-
gone degeneration. There are no vessels either in the envel-
ope or the contents, which, in addition to the elements just
mentioned, consist of cholestrine and stearine.

In addition to these there are osseous tumors (exostoses),
growing from the cranial bones, and which may or may not
be syphilitic, lipomatous, enchondromatous, mucous^ and
several other species of tumors, which are treated of fully in
the special monographs on the subject, but which need not
detain us in the present connection.'

Two bodies cannot occupy the same space at the same
time. In a state of health, the brain so nearly fills the cra-
nial cavity that there is barely room for those variations in
the amount of blood and ventricular fluid which occur with-
in the normal limits. The growth of a tumor, therefore, is
at the expense of the brain. As the former increases in size,
the latter diminishes, and hence some of the symptoms re-
sulting from tumors are similar to those which follow atro-
phy or sclerosis. Besides, we have other consequent effects,
such as oedema, congestion, anaemia, haemorrhage, inflamma-
tion, or softening.

Wlien cerebral tumors press upon the cranial nerves they
produce fatty degeneration and atrophy. This effect is
manifested by alterations of sensibility or of motility in the
parts supplied by these nerves. In the eyes, however, in ad-
dition, the changes can be seen with the ophthalmoscope.
They consist in the main of atrophy of the optic disk, disap-

' For a very full and complete essay on the subject of Cerebral Tumors, the
reader is referred to Dr. J, W. Ogle's cases illustrating the Formation of Mor-
bid Growths, Deposits, Tumors, Cysts, etc., in connection with the Brain and
Spinal Cord and their investing Membranes, British and Foreign Medico-Chirur-
gical Review, 1864- 65.
21

322

DISEASES OF THE BRAIN.

pearance of the vessels, congestion of the retina, or hsemor-
rhage or serous infiltration with detachment. As Jaccoud
remarks, easily appreciated by the ophthalmoscope, these
lesions have a real importance in clinical diagnosis.

As to the relation between the symptoms and the seat
of the lesion, the principles enunciated under the head of
cerebral haemorrhage are applicable to cerebral tumors.

Treatment. — There is no treatment calculated to cure the
patient, unless a syphilitic taint can be ascertained. It is
well, however, even when there are no positive indications
of the existence of such a diathesis, to act upon the presump-
tion that it does exist, and to administer mercury in some
form with the iodide of potassium. By adopting this prin-
ciple, I have several times succeeded in curing patients who
exhibited the most positive indications of sufiering from tu-
mor of the brain. One very remarkable case was that of a
gentleman who consulted me several months since for ptosis,
double vision, dilatation of the pupil, vertigo, and cephalal-
gia. The opinion was expressed by other physicians that
there was a cerebral tumor, and I entirely accorded with
the view. The gentleman had no recollection of ever hav-
ing had a chancre of any kind, but I nevertheless adminis-
tered the bichloride of mercury and iodide of potassium, ac-
cording to the following formula : ^ . hyd, bichlor. (corros),
grs. ij, potass, iodidi 3 v, aquse § iv, M. ft. sol. Dose, tea-
spoonful three times a day. At the next visit of the patient
he remembered that when in China, several years previ-
ously, he had contracted a chancre for which he was treated.
I continued the treatment, conjoining it with the use of elec-
tricity to the eye so as to act upon the paralyzed muscles,
and had the satisfaction to see a gradual but steady im-
provement take place, till eventually in the course of a few
weeks the cure was complete.

Another case was that of a lady who consulted me in
July, 1870, for agonizing pain in the head, vertigo,' and pa-
ralysis of the third nerve of the left side, the latter producing

TUMORS OF THE BRAIN.

323

ptosis, external strabismus, and consequent diplopia. I could
discover no evidence of syphilis, but I nevertheless adminis-
tered the bichloride of mercury and the iodide of potassium,
as in the foregoing case. The induced or faradaic current
was applied to the eye, and the patient soon began to mend.
The headache disappeared first, then the vertigo, and event-
ually the paralysis. Subsequently I ascertained from the
lady's husband that it was barely possible he might have in-
fected his wife. I have no doubt whatever that he did.

The medication recommended can do no harm. There
is, therefore, no reason why the patient should not have the
chance of being benefited by it.

The prescription mentioned is a very eligible form for
administering both the mercury and iodide of potassium.
Salivation is never caused by it, and the stomach generally
tolerates it well. Of course the proportions of the ingredi-
ents can be altered, as may seem best in individual cases.

The induced galvanic current is beneficial in restoring
contractility to the paralyzed muscles. When applied to
the eye the lids should be closed, one electrode, a wet sponge,
is placed on them, the other is held in the hand or placed
on the nape of the neck, and a current not so strong as to
cause any considerable pain is then allowed to pass through
the intervening tissues. For the relief of the pain attend-
ant on cerebral tumors, morphia may be administered hypo-
dermically, or, what I have found advantageous in several
cases, the extract of Indian hemp, as recommended by Key-
nolds, may be used.

Counter-irritation, as produced by the actual cautery or
other less powerful means, can do no possible good, and
only adds to the discomfort of the patient .

CHAPTEK XY.

INSANITY.
GENERAL PRINCIPLES.

The brain is the chief organ from which the force called
the mind is evolved, and, so far as the present inquiry goes,
may be regarded as the only one. For, though, wherever
there is gray nerve-tissue, nervous force is generated, and
though all nervous force partakes more or less of the charac-
ter of that which we call mind, its qualities are not of such
a nature as to bring their aberrations within the scope of
this chapter.

By mind, therefore, we understand a force developed by
nervous action, and especially by the action of the brain.
The modifications which this force, in its cerebral relations,
undergoes outside of the limits of health, either as regards
excess, deficiency, or variation of quality, are embraced un-
der the term insanity. Some authors have doubted the
connection between the brain and the mind. Though we
all feel that the relation does exist, it is perhaps as well to
state briefly the facts which tend to establish the dependence
of the one upon the functionation of the other. They have
been well set forth by Mr. Bain : *

1. The action of an organ, even within the limits of
health, frequently gives rise to sensations of various kinds,

1 The Senses and the Intellect, second edition, London, 186 t, p. 11. Also
Mental and Moral Science ; a Compendium of Psychology and Ethics, London,
1868, p. 6.

INSANITY.

325

and sliglit functional derangements are very distinctly felt.
Thus, the pain of indigestion is referred to the stomach or
bowels, as the case may be ; difficulties with the urinary ex-
cretion cause uneasiness in the kidneys; derangements in
the secretion of the bile cause pain in the liver ; loud noises
produce unpleasant feelings in the ears, and excessive or im-
proper use of the eyes causes pain in these organs. So it is
with the brain. Though ordinarily we are not conscious by
any particular sensation that we are using it when we think
(and the same is true mutatis mutandis of the other organs
mentioned), yet inordinate mental exertion gives rise to
headache, vertigo, and other derangements of sensibility, re-
ferable to the brain. I have had many patients under my
charge in whom very slight mental action invariably pro-
duced pain in the head. It is well known that the brain
becomes diseased when it is unduly taxed, just as does the
spinal cord, the eye, or a muscle.

2. Injury or disease of the brain impairs in some way or
other the powers of the mind. A blow on the head causes
confusion of thought, and, if hard enough, may abolish con-
sciousness or the power of thought altogether. A piece of
fractured bone, or a bullet, pressing on the brain, likewise
destroys the ability to think ; and though, as in cases cited
in another part of this treatise, there are examples of ter-
rible wounds of the brain without, for a time, notable im-
pairment of the mind, there is some loss from the first,
and eventually the patients die with head-symptoms. The
various affections of the brain which have been considered
in this treatise, without exception produce, at some time or
other of their course, derangement in the evolution of mind.
Insanity, too, very often is shown, after death, to have been
accompanied by structural changes in the brain.

3. The action of the brain, like that of other organs,
results in the disintegration of its substance, and this de-
struction of tissue is in direct proportion to the amount of
mental work done. We find, therefore, that the alkaline

•

326

DISEASES OF THE BRAIN.

phosphates, which are mainly derived from the destructive
metamorphosis of the nervous tissue, and which are excreted
by the kidneys, are increased in quantity after severe intel-
lectual labor, and are diminished by mental quietude. In
a memoir published several years ago, I gave the results of
a series of experiments performed upon myself, whicli show
very conclusively that increased use of the brain causes in-
creased decay.'

4. The size of the brain is well known to bear a direct
relation to the intelligence of the individual ; and, when all
other conditions are alike, it may be said that the largest
brain will produce the greatest amount of mental energy.
Quality is, however, also an important factor, and when
with great size we also have a large amount of gray matter,
the intellectual capacity is at its maximum.

Thus, Dr. Thurnam ' has shown that the average weight
of the brain in Europeans is 49 ounces, while in ten men
remarkable for their intellectual development it was 54.7
ounces. Of these, the brain of Cuvier, the celebrated natu-
ralist, weighed 64.5 ounces, Spurzheim's 65.06, and Daniel
Webster's 53.5. On the other hand, the brain is small in
idiots. In three idiots whose ages were sixteen, forty, and
fifty years, Tiedemann found the weight of their respective
brains to be 19f , 25f , and 22| ounces. Mr. Gore ' has re-
ported the case of a woman, forty-two years of age, whose
intellect was infantine, who could scarcely say a few words,
whose gait was unsteady, and whose chief occupation was
carrying and nursing a doll. After death, her brain, care-
fully weighed, was found to weigh but 10 ounces and 5 grains.

Mr. Marshall * has also reported a case of microcephaly

' Urological Contributions, American Journal of the Medical Sciences, April,
1856, p. 330. Also Physiological Memoirs, Philadelphia, 1863, p. 17.
^ Journal of Mental Science, April, 1866.

* Notes of a Case of Microcephaly, Anthropological Review, No. 1, May,
1863, p. 168.

* Brain and Calvarium of a Microcephale. Transactions of the Anthropo-
logical Society of London, in Anthropological Review, No. 2, August, 1863, p. 8.

INSANITY.

327

existing in the person of a boy twelve years old, whose brain
weighed but 8| ounces. The convolutions were strongly
marked, though few in number and narrow.

5. Experiments performed upon the nerves and nerve-
centres show that from the brain proceeds the force by
which muscles are moved, and that it is the organ by whicli
sensations are perceived. Thus, division of a nerve supply-
ing a certain muscle cuts off the connection between the
brain and that muscle, and hence the will can no longer act
upon it. Division of the optic nerve, for instance, prevents
the perception of visual images.

From all of which considerations the connection between
the brain and the mind is as clearly made out as an}'- other
fact in physiology.

The mind differs from forces in general, in being com-
pound ; that is, in being made up of several other forces.
These are perception, the intellect, the emotions, and the
will. All the mental manifestations of which the brain is
capable are embraced in one or more of these parts. Ei-
ther one of them may be exercised independently of the
other, though they are very intimately connected, and in all
continuous mental processes are brought more or less into
relative and consecutive action. As constituting; the basis
of my classification of the several forms of insanity, it is ex-
pedient to describe these four sub-forces of the mind.

1. Pekception. — By perception is to be understood that
part of the mind whose office it is to place the individual in
relation with external objects. For the evolution of this
force the brain is in intimate relation with certain special
organs which serve the purpose of receiving impressions of
objects. Thus an image is formed upon the retina, and the
optic nerve transmits the excitation to its ganglion or part
of the brain. This at once functionates, the force called
perception is evolved, and the image is perceived. If the
retina be sufiiciently diseased, the image is not formed; if
the optic nerve is in an abnormal condition, the excitation is

328

DISEASES OF THE BRAIN.

not transmitted ; if the ganglion be disordered, the percep-
tive force is not evolved.

Like reasoning is applicable to the other senses — hear-
ing, taste, smell, and touch.

Perception may be exercised -without any superior in-
tellectual act — without any ideation whatever. Thus, if the
cerebrum of a pigeon be removed, the animal is still capa-
ble of seeing and of hearing, but it obtains no idea from
these senses. The mind, with the exception of perception,
is lost,

2. The Intellect. — In the normal condition of the
brain the excitation of a sense and the consequent percep-
tion do not stop at the special ganglion of that sense, but
are transmitted to a more complex part of the brain where
the perception is resolved into an idea. Thus the image
impressed upon the retina, the perception of which has been
formed by a sensory ganglion, ultimately causes the evolu-
tion of another force by which all its attributes capable of
being represented upon the retina are more or less perfect-
ly appreciated according to the structural qualities of the
ideational centre. To the formation of the idea several im-
portant faculties and modes of expression of the intellect
contribute.

Thus, if we suppose the retina to have received the
image of a ball, a higher ganglion converts this into a per-
ception, and a still higher one into an idea ; and this idea
relates to the size, the form, the color, the material, etc.,
primarily, and the origin, uses, ownership, etc., secondarily.
In gaining this conception of the thing impressed upon the
retina, the memory, judgment, and other faculties of the in-
tellect are brought into action, and the process of reasoning
is carried on.

3. The Emotions. — An idea in its turn excites another
part of the brain to action, and an emotion is produced, or
this last-named force may be evolved under certain circum-
Btances without the intermediation of the idea, but solely

INSANITY.

329

from the transmission of a perception to the emotional gan-
glion.

An emotion is that pleasurable or painful feeling which
arises in us in consequence of sensorial impressions or intel-
lectual action. According to Bain, the word emotion is used
to comprehend all that is imderstood by feelings, states of
feeling, pleasure, pain, passion, sentiments, affection, etc.

Within the limits of health the emotions act powerfully
on certain organs of the body, and thus express their own
activity. Thus grief is exhibited by the flow of tears from
over-excitation of the lachrymal gland; extreme joy may
also cause weeping; the jaw falls, and the angles of the
mouth curve downward in mortification or son-ow, while in
pleasure the face expands laterally. The eyes, the nose,
and the mouth, are the three facial centres from which emo-
tional expression is mainly produced. Other organs of the
body, as the salivary glands, the heart, the mammary glands,
the liver, the kidneys, and, in fact, nearly every viscus of
the body, may exhibit the effects of emotion by the trans-
mission of excitations through the sympathetic nerve. Most
of the resulting effects are due to the fact that the sympa-
thetic nerve especially presides over the vaso-motor system,
and thus regulates the calibre of the blood-vessels.

The "Will. — By volition acts are performed. Some acts
are automatic, but all done in consequence of intellection
are the result of willing, and are for some specific purpose
connected with an idea. Yolition in the series of mental
manifestations may precede emotion, but it always follows
ideation.

To sum up these outlines : A person walking in the
street sees a man on the opposite side of the way — Percep-
tion / he recognizes him as a friend whom he has not met
for many years — Intellect / he determines to go across and
speak to him — Will; he does so, and exhibits joy at the
reunion — Emotion.

Or, to alter the sequence somewhat :

330

DISEASES OF THE BRAIN.

A person at a theatre sees and hears an actor on the
stage — Perception ; the attitudes, gestures, and words of
the player call up certain ideas — Intellect ; he is moved to
great joy or grief — Emotion / and, determining to recognize
the ability of the actor — Will^ claps his hands, or throws
him a bouquet.

The mind, therefore, as before stated, is a compound
force evolved by the brain, and its elements are perception,
intellect, emotion, and will. The sun likewise evolves a
compound force, and its elements are light, heat, and actin-
ism. One of these forces, light, is again divisible into sev-
eral primary colors, and the intellect of man, one of the
mental forces, is made up of faculties. It would be easy to
pursue the analogy still further, but enough has been said
to indicate how clearly the relationship between brain and
mind is that of matter and force.

In individuals whose brains are well formed, and free
from structural changes, and are nourished with a due sup-
ply— neither excessive nor deficient — of healthy blood, the
perception, the intellect, the emotions, and the will, act in a
manner common to mankind in general. Slight changes in
the formation or nutrition of the brain induce corresponding
changes in the several parts of the mind, or in it as a whole.
As no two brains are precisely alike, so no two persons are
precisely alike in their mental processes. So long, however,
as the deviations are not directly at variance with the aver-
age human mind the individual is sane. If they are at va-
riance, he is insane. But within the limits of mental health
marked irregularities are met with in different parts of the
mind. Thus some persons are noted for never perceiving
things as the majority of people perceive them. Others
have the emotional system inordinately or deficiently de-
veloped. Others are weak in judgment, defective in mem-
ory, feeble in powers of application, or vacillating in their
opinions. Others, again, are lacking in volitional power —
in the ability to perform certain acts, to refrain from others.

INSANITY.

331

or to follow a definite course of action which the intellect
tells them is expedient and wise.

Eccentricity. — Persons whose minds deviate in some one
^ or more notable respects from the ordinary standard, but
yet whose mental processes are not directly at variance with
that standard, are said to be eccentric. It is not always
easy to draw the line between strong eccentricity and mild
insanity. About the former, however, there is this marked
characteristic: that its manifestations are according to a
fixed system, are not founded on delusions, and are gener-
ally excited by those emotions or desires which are reflected
back to the individual, such as vanity, pride, the love of ap-
probation, or of notoriety, etc. Eccentric persons stand
upon the verge of insanity with a decided predisposition to
mental disease, and ordinarily do not pass the limit merely
for want of a sufficient exciting cause. Several instances of
eccentricity passing into undoubted insanity have come
under my observation. In one of these, a lady had since
her childhood shown a singularity of conduct as regarded
her table-furniture, which she would have of no other ma-
terial than copper. She carried this fancy to such an extent
that even the knives were made of copper. People laughed
at her, and tried to reason her out of her whim, but in vain.
In no other respect was there any evidence of mental aberra-
tion. She was intelligent, by no means excitable, and in
the enjoyment of excellent health. An uncle had, however,
died insane. A trifling circumstance started in her a new
train of thought, and excited emotions which she could not
control. She read in the morning paper that a Mr. Kop-
perman had arrived at one of the hotels, and she announced
her determination to call on him. Her friends endeavored
to dissuade her, but without avail. She went to the hotel,
and was told he had just left for Chicago. "Without return-
ing to her home, she bought a ticket for Chicago, and ac-
tually started on the next train for that city. The tele-
graph, however, overtook her, and she was brought back

332

DISEASES OF THE BRAIN.

from Rochester, raving of her love for a man she had never
seen, and whose name alone had been associated in her
mind with her fancy for copper table-furniture. She died
of acute mania within a month.

In another case a young man, a clerk in a city bank, had
jfor several years exhibited peculiarities in the keeping of
his books. He was exceedingly exact in his accounts, but
after the bank was closed for the day he always remained
several hours, during which he ornamented each page of his
day's work with arabesques in different-colored inks. His
fellow-clerks amused themselves at his expense, but his su-
perior officers, knowing his value, never interfered with him
in his amusement. Gradually, however, he conceived the
idea that they were displeased with him, and at last this be-
came so firmly rooted in his mind that he resigned his posi-
tion, notwithstanding the protestations of the directors that
his idea was erroneous. Delusions of various kinds soon
supervened, and he is now hopelessly insane.

Inquiry will frequently disclose the fact that the insane
have been eccentric for several years before becoming
affected with cerebral disease to such an extent as to pro-
duce decided mental aberration.

Definition of Insanity. — Every medical witness, who ap-
pears in a case involving the mental capacity or responsi-
bility of an individual, is expected to give a definition of in-
sanity. It is extremely difficult to do this satisfactorily, as
it is also with a great many other terms which are applied
to complex forces. It is difficult to give such a meaning to
the word as will cover all possible cases of deficiency or ab-
erration of the mental faculties, and yet not include those
instances of cerebral disease which cannot properly be
classed under this head. For the purpose of showing how
authors have varied in their ideas of the signification of the
word, as well as for the instruction of the reader seeking for
information on the point, I quote a number of definitions
from some of the most eminent autliorities :

INSANITY.

333

Dr. John Haslam/ who has written one of the most
lucid treatises on insanity in the English language, and
who was for many years one of the physicians to Bethlehem
Hospital, confesses his inability to give a thoroughly com-
prehensive and yet a sufficiently exclusive definition of mad-
ness ; and Dr. Prichard * frankly admits that it is better to
give up the attempt to define insanity in general terms.
Notwithstanding the reluctance of these and other medical
authorities to formularize the phenomena of insanity, the at-
tempt has frequently been made with more or less approach
to completeness. If the word can be even imperfectly de-
fined in simple language without conveying erroneous ideas,
it is certainly advisable to make an efibrt in this direction.

According to Hofi'bauer,* an individual is insane when
the understanding is diverted or changed in its operations ;
when he is powerless to avail himself of his intellectual fac-
ulties, or to make known his wishes in a suitable manner.

This definition, though embracing all cases of insanity,
is not satisfactory, for the reason that it is applicable to cer-
tain cerebral disorders which are not properly classed under
this head. Among these may be mentioned apoplexy, and
concussion and compression of the brain.

Dr. Bucknill, in his " Essay on Criminal Lunacy," defines
insanity as " a condition of the mind in which a false action
of conception or judgment, a defective power of the will, or
an uncontrollable violence of the emotions and instincts
has separately or conjointly been produced by disease."
This definition is a very excellent one, but still includes
those diseases of the brain attended with unconsciousness
which are not insanity.

Dr. Guislain,* an eminent Belgian authority, says that

' Observations on Madness and Melancholy, etc., second edition, London,
1809, p. 37.

5 Article Insanity, in Cyclopaedia of Practical Medicine.

2 Untersuchungen iiber die Krankheiten der Seele. Halle, 1803, p. 11.

* Le9ons sur les Phrenopathies, tome i., p. 45.

334

DISEASES OF THE BKAIN.

" insanity is a morbid derangement of the mental faculties
unattended by fever, and chronic in its character, which
deprives man of the power of thinking and acting freely as
regards his happiness, preservation, and responsibility."

The objections to this definition, in addition to those ap-
plicable to the others given, are that insanity is not neces-
sarily unaccompanied by fever, and that it is not always a
chronic affection.

Drs. Bucknill and Tuke,* quoting from Maimon, say
that " mental health consists in that state in which the will
is free, and in which it can exercise its empire without ob-
stacle. Any condition different to this is a disease of the
mind, and if it is asked, What is the will ? it may be re-
plied, according to the definition of Marc, that it is a moral
faculty which originates, directs, prevents, or modifies the
physical and moral acts which are submitted to it."

The late Prof. Oilman, of this city, who had given a
great deal of study to the subject, declared that the best
definition he had been able to make was, that " insanity is
a disease of the brain by which the freedom of the will is
impaired." This has the advantage of being short and of
being to the point. Other diseases, however, are included
in its terms.

It would be easy to go on and quote numerous other au-
thorities on this point, but enough have been cited to show
the general import which physicians give to the word in-
sanity. I will therefore dismiss the further consideration
of this division of the subject, by stating that my own idea
of insanity is based entirely on the fact, that as the healthy
mind results from a healthy brain, so a disordered mind
comes from a diseased brain. Insanity, therefore, strictly
speaking, is only a symptom, and I would define it as —

A manifestation of disease of the brain, characterized by
a general or partial derangement of one or more faculties of

' A Manual of Psychological Medicine, etc., London, 1858, p. 79.

INSANITY.

335

the mind, and in which, while consciousness is not abolished,
mental freedom is perverted, weakened, or destroyed.

An essential feature of the definition of insanity here
given is, that it depends directly upon a diseased condition
of the brain. This is the immediate cause, and may consist
of structural changes due to injury, disease, or malforma-
tion, or of malnutrition, the result of excessive intellectual
exertion, the action of powerful emotions, irritations in dis-
tant parts of the body, the sudden stoppage of the digestive
process, the introduction into the system of certain drugs,
such as opium, alcohol, belladonna, etc., the retention in the
organism of substances poisonous in character, but which in
health are excreted, and of other factors capable of altering
the quantity or quality of the blood circulating through the
cerebral vessels, or of accelerating or retarding the meta-
morphosis of tissue which the brain undergoes in common
with all the other organs of the body. These causes, with
others, will be more fully considered hereafter.

Classification. — ^]\Iany classifications have been made of
the several manifestations of insanity. As is well known,
mental disease appears under difierent characters, just as
does the healthy mind. Some authors have been exceed-
ingly minute in their arrangement, making a type of the
disease from each particular symptom or delusion the pa-
tient may show. Others, again, are metaphysical and un-
practical.

The classification of Esquirol ' has been very generally
adopted, with more or less modification according to the
peculiar ideas of the authors. Although arbitrary, and
based upon the principle of regarding the symptom as the
disease, it is certainly the best of its kind ; and, though made
more than thirty years ago, is still followed by many writers.
The terms employed by Esquirol are so frequently met with
in works on insanity, that I give his classification as a part
of the history of the subject :

' Des Maladies Mentales, tome i., p. 11, Paris, 1838.

336

DISEASES OF THE BRAIN.

1. Melancholia. — Perversion of the understanding in re-
gard to an object or a small number of objects, with the
predominance of sadness and depression of mind.

2. Monomania. — Perversion of understanding limited to
a single object or a small class of objects, with predomi-
nance of mental excitement.

3. Mania. — A condition in which the perversion of un-
derstanding embraces all kinds of objects, and is attended
with mental excitement.

4. Dementia. — A condition in which those affected are
incapable of reasoning, from the fact that the organs of
thought have lost their energy and the force necessary for
performing their functions.

5. Imbecility or Idiocy. — A condition in which the or-
gans have never been sufficiently well-conformed to permit
those affected to reason correctly.

One of the latest and most able writers on the subject
of mental derangement is Dr. Maudsley," and he classifies
the several forms of insanity according to the mental symp-
toms, as follows :

1. Maniacal perversion of the affective life. Mania sine

delirio.

2. Melancholic depression without delusion. Simple melan-

cholia.

3. Moral alienation proper. Approaching this, but not

reaching the degree of positive insanity, is the insane
temperament.

> The Physiology and Pathology of the Mind. London and New York, 1867,

I. — Affective or Pathetic Insanity.

II. — Ideational Insanity.

1. General.

a, Mania.

5, Melancholia,

p. 323.

INSANITY

337

2. Partial.

a, Monomania.
h, Melancholia.

3. Dementia, |

-i. General Paralysis.
5. Idiocy or Imbecility.

In 1867, an International Congress of Alienists was held
in Paris, and a committee, appointed by that body to make
a classification, reported the following :

I. Simple insanity, embracing the different varieties of
mania, melancholia, and monomania, circular insanity and
mixed insanity, delusion of persecution, moral insanity, and
the dementia following these different forms of insanity.

II. Epileptic insanity, or insanity with epilepsy, whether
the convulsive affection has preceded the insanity and has
seemed to have been the cause ; or whether, on the contrary,
it has appeared during the course of the mental disease only
as a symptom or a complication.

III. Paralytic Insanity. — This commission regards the
disease called general paralysis of the insane as a distinct
morbid entity, and not at all as a complication, a termina-
tion of insanity. It proposes, then, to comprehend under
the name of paralytic insane all the insane who show in any
degree whatever the characteristic symptoms of this disease.

IV. Senile dementia, which we would define as the slow
and progressive enfeeblement of the intellectual and moral
faculties consequent upon old age.

y. Orgam,ic dementia / a term by which the commission
means to designate a disease which is neither the dementia
consequent upon insanity or epilepsy, nor paralytic demen-
tia, nor senile dementia, but that which is consequent upon
organic lesion of the brain, nearly always local, and which
presents, as an almost constant symptom, hemiplegic occur-
rences more or less prolonged.

338

DISEASES OF THE BRAIN.

YI. Idiocy^ characterized by the absence or arrest of
development of the intellectual and moral faculties. Imbe-
cility and weakness of mind constitute hereof two degrees
or varieties.

YII. Cretinism^ characterized by a lesion of the intel-
lectual faculties more or less analogous to that observed in
idiocy, but with which is uniformly associated a character-
istic vicious conformation of the body, an arrest of the de-
velopment of the entirety of the organism. Outside of
these typical forms there are others, such as —

1. Delirium tremens.

2. Delirium of acute diseases ; traumatic delirium.

3. Simple epilepsy.

My own classification is much simpler than most that
have been proposed, and is based entirely on the division
of mind given. In part it has been brought forward by
other authors, though with different explanations of the
terms employed.

I. Perceptional insanity^ characterized by the tendency
to the formation of erroneous perception either from false
impressions of real objects (illusions), or from no external
excitation whatever (hallucinations).

II. Intellectual insanity^ characterized by the existence
of delusions.

III. Emotional insanity^ characterized by the uncon-
trolled or imperfectly-controlled predominance of one or
more of the emotions.

lY. Volitional insanity^ in which there is an inability
to exert the full will-power either afiirmativel}' or nega-
tively.

Y. Mania, characterized by the union of two or all four
of these forms in the same individual.

YI. General jpa/ralysis, a peculiar forai of insanity, at-
tended with progressively-advancing loss of mental and mo-
tor power.

YII. Idiocy und dementia : the first due to the fact that

INSANITY.

339

there are original structural defects in tlie brain ; the sec-
ond resulting from the supervention of organic changes in
a brain originally of normal power.

In a work like the present, embracing the diseases of the
whole nervous system, it is, of course, impossible to consider
at full length the very interesting subject of insanity. I
shall endeavor, however, to give certain prominent features,
referring the reader, for more complete information, to the
monographs treating specifically of diseases of the mind.'

But, before proceeding to describe the several types men-
tioned, there are some important symptoms of mental disor-
der, the character and import of which must be clearly un-
derstood. These are illusion, hallucination, delusion, inco-
herence, and delirium.

Illusion. — An illusion is a false perception of a real sen-
sorial impression. Thus a person seeing a ball roll over the
floor, and imagining it to be a mouse, has an illusion of the
sense of sight ; another, hearing the pattering of the rain on
the roof, and perceiving in this sound the voice of some one
calling him, has an illusion of the sense of hearing ; another,
having some bitter substance placed upon his tongue, and
forming the perception of a sweet flavor, has an illusion of
the sense of taste ; and so on as regards the other senses.
In all such cases there is a material basis for the perception,
but this latter is not in exact relation with the former.

Illusions are not always indicative of cerebral disorder ;
indeed, they are very common with all of us under certain
circumstances. It is, perhaps, never the case that the per-
ception is precisely in accordance with the real properties
of the substance making tlie sensorial impression. We never
see, hear, taste, smell, or feel things exactly as they are.
This imperfection may be due to surrounding circumstances
not being favorable. Insufficient light may thus make our

' No work is better calculated to give philosophical views of the subject of
insanity than the treatise of Dr. Maudsley, on the " Physiology and Pathology
of the Mind." His little work on the "Body and Mind" is also admirable.

340

DISEASES OF THE BRAIN.

vision imperfect ; loud noises may render us incapable of ap-
preciating gentle sounds. A stronglj-sapid substance pre-
viously rubbed over the tongue and fauces prevents our dis-
tinguishing delicate flavors ; a powerful odor may make
such an impression on the schneiderian membrane that
other odors for a long time smell like it, and exposure to
very cold weather interferes markedly with the discriminat-
ing power of the sense of touch.

Imperfect perceptions are often formed in consequence
of the perceptive ganglia being otherwise occupied. Thus,
if we are looking intently at some object of interest, we are
apt not to attend to the sounds which reach our ears, and
consequently no clear perception of them is formed.

Illusions of all the senses, but especially of sight and
hearing, are met with in insanity, and particularly in those
acute forms characterized by the presence of delirium.

Hallucination. — An hallucination is a false perception
without any material basis, and is centric in its origin. It
is more, therefore, than an erroneous interpretation of a real
object, for it is entirely formed by the mind. An individ-
ual, who, on looking at a blank wall, perceives it to be cov-
ered with pictures, has an hallucination ; another, who, when
no sounds reach his ear, hears voices whispering to him, also
sufiers from an hallucination, and such false perceptions
may be created as regards all kinds of sensorial excitations.
The organs of the senses, in fact, are not necessary to the
existence of hallucinations. Thus, if the eyes be closed,
images may still be seen ; if the hearing be lost, voices may
still be heard, and the reason for this is found in the fact
that the erroneous perception constituting the hallucination
is formed in that part of the brain which ordinarily requires
the excitation of a sensorial impression for its functionation.
Hallucinations are always evidence of cerebral derangement,
and are common phenomena of insanity. They may be ex-
cited by emotions of various kinds, by which the character
or quantity of the blood circulating in the brain is changed.

INSANITY,

341

by intellectual exertion, by certain drugs, and many other
factors to be presently more fully considered.

Delusion. — Illusions and hallucinations may exist, and
the individual be perfectly sensible that they are not reali-
ties. In such cases the intellect is not involved. But, if he
accepts his false perceptions as facts, his intellect partici-
pates, and he has delusions. A delusion is, therefore, a false
belief. It may be based upon an illusion or an hallucination,
may result from false reasoning in regard to real occurrences,
or be evolved out of the intellect spontaneously by the result
of imperfect information, or of an inability to weigh evidence
or to discriminate between the true and the false. Delu-
sions are not a test of insanity, as most lawyers and msLXij
physicians believe. If they were, one-half the world would
be trying to put the other half in lunatic asylums ! They
may be present without coexistent insanity, and many cases
run their course without them.

To be indicative of insanity, a delusion must be contrary
to the customary mode of thought of the individual. Thus
a believer in spiritualism is not necessarily insane because
he sees and converses with the spirit of Benjamin Franklin,
for it is a part of his mentality to believe in the existence of
spirits and in the possibility of evoking them so as to see
them and talk with them. But, if a non-believer in spirit-
ualism should imagine that he was in the habit of seeing
Franklin's spirit and of conversing with it, it would be good
evidence of his insanity. And further, though the spirit-
ualist might think he had interviews with Franklin, and
still be sane, yet if he believe, without foundation and con-
trary to evidence, that his brother had tried to poison him,
he would have a delusion sufficient to indicate his insanity.

At a former period of the world's history, a belief in the
possibility of seeing devils and demons of various kinds, and
of suffering from their torments, was commonly entertained.
Indeed, it is religiously held now by a great many otherwise
sensible people. Such a belief is, according to my mode of

342

DISEASES or THE BRAIN.

thought, a delusion, and probably nine-tenths of those who
read this treatise will agree with me in so regarding it. But
it certainly would not be safe to consider every one holding
such a creed as insane. A like reasoning applies to the
holders of every other form of belief not in accordance with
our own. A delusion, to be indicative of insanity, must be
such a belief as would not be entertained in the ordinary
normal condition of the individual, must have been formed
without such evidence as would have been necessary to con-
vince in health, and must be held against such positive testi-
mony as would have in health sufficed to eradicate it.

Insanity may exist without delusions at any time being
present. Thus there may be emotional insanity, the main
feature of which consists of mental depression with an un-
reasoning tendency to suicide ; or there may be volitional in-
sanity, characterized by an inability to refrain from setting
fire to neighbors' houses, or from committing homicide.

Incoherence. — A person is said to be incolierent when
the words he utters are without proper relation to each
other, or when his language is not in accordance with his
ideas. As an example of incoherence, I cite the following
letter which I received a few days since from a patient :

" In the Neck, January 7, 1871.

" Dear Sir : I said he was in my own conscience that
the book was confined I quote the long time with eccentri-
city in the common way. This is in memory to my upshot
which was incorrect at the final oblivion. Dogs and money
consistency with foundlings without ante bellum which was
in statu quo.

" This is passive in contiguity with the works met in
the creation of existence.

" Very commingle

" in good faith

" J. S. W ."

This exhibits an extreme case, as there is not an idea to

INSANITY.

343

be obtained from the language used. Such instances are,
however, common enough.

Incoherence is a prominent feature of delirium, and is
sometimes met with in the clironic insane. It is directly
due either to the impossibility of keeping the attention suf-
ficiently long on one idea for its full consideration, or to a
hke difhculty in coordinating those parts of the brain which
are concerned in the formation and expression of thoughts.

Delirium. — Delirium is that condition in which there
are illusions, hallucinations, delusions, and incoherence, to-
gether with a general excess of motility, an inability to
sleep, and acceleration of pulse. In acute delirium these
phenomena are well marked ; in the low and chronic forms
they are less strongly indicated. Sometimes one or the
other of these elements notably predominates. Delirium is
present in the early stage of acute mania, and may exist as
an accompaniment of certain diseases of the brain which do
not ordinarily cause insanity, such as cerebral congestion or
anaemia. It is also common in fevers and in several other
disorders of the system.

I. — Perceptional Insanity.

In uncomplicated perceptional insanity, those parts of
the brain only are disordered which are concerned in the for-
mation of perceptions. It constitutes the primary form of
mental aberration, and of itself is not of such a character as
to lessen the responsibility of the individual, or to warrant
any interference with his rights. It consists entirely in
false perceptions ; and if the intellect is for a moment de-
ceived, the error is immediately corrected. As already
stated, these are either illusions or hallucinations. In some
cases these erroneous perceptions may coexist in the same
individual. They may be related to all the senses, but are
especially common as regards sight and hearing.

Illusions, as already mentioned, are not necessarily due
to any centric difficulty, though such an origin is common.

344

DISEASES OF THE BRAIN.

Thus, it is an illusion if a person on looking at an object sees
two images. This result is due to some cause destroying
the parallelism of the visual axes, and may be produced
by a tumor of the orbit or by paralysis of one or the other
of the ocular muscles. Even in such a case, if the paralysis
were due to central lesion, the higher ganglia of the brain
might escape implication. Illusions are often excited by
emotional disturbance, and are then probably directly due
to some disturbance of the cerebral circulation. The false
perceptions called hallucinations are of more importance
than illusions, in the symptomatology of insanity in general.
In the purely perceptional form of mental aberration they
are also exceedingly interesting, and are very often trouble-
some symptoms. Thus, a gentleman, who had overworked
himself in financial business, was subject to hallucinations of
hearing, which, however, did not in the least impose on his
intellect. As he walked through the streets to his place of
business, he heard a voice continually whispering to him,
" Take care — take care ! " So strong was the impression
made, that he often involuntarily turned round to see who
was speaking to him. In another case, a gentleman saw im-
ages of various kinds as soon as his head touched the pil-
low, though they were never present when he was standing
or sitting.

The case of ISTicolai, the G-erman bookseller of the last
century, is well known as a remarkable example, and others
are afforded in the cases of Jerome Cardan, Pascal, and
many other noted personages.

Like illusions,^ the immediate cause of hallucinations is
generally derangement of the cerebral circulation, either as
regards quantity or quality.

As is well known, they are frequently produced by alco-

> For a fuller account of the subjects of illusions and hallucinations, the
reader is referred to the author's works on Sleep and its Derangements : J. B.
Lippincott & Co., Philadelphia ; and the Physics and Physiology of Spiritualism :
D. Appleton & Co., New York.

INSANITY.

345

holic liquors, opium, belladonna, Indian hemp, and other
drugs. They may also result from mental exertion and
emotional disturbance, from an overloaded stomach, or may
occur in the course of various diseases, especially those of a
febrile or exhausting character.

Perceptional insanity may make its appearance sudden-
ly, the first evidence of its presence being the illusion or
hallucination. Usually, however, there are prodromata in-
dicating cerebral derangement. These are pain in the head,
irritabiHty . of temper, suflusion of the eyes, noises in the
ears, a general restlessness, and some febrile excitement.
The skin is generally dry, the mouth parched, the bowels
costive, and the urine high colored and scanty. If not ar-
rested, it may pass into one or the other of the following
types of mental aberration.

II. — Intellectual Insanity.

The essential feature of intellectual insanity is delusion.
It may be developed suddenly, or, as is generally the case,
preceded by evidences of cerebral disorder, which, though
at the time of their occurrence not attracting particular at-
tention, are called to mind by the observers after the disease
has become fully developed.

In the first stages of intellectual insanity it is not often
that the delusions are fixed, and they may succeed each
other with such rapidity that the patient resembles one af-
fected with mania. They may be based on illusions or hal-
lucinations, or may arise from the reasoning of the patient
from purely imaginary premises not connected with the
senses. Sometimes they are spontaneous, and at others
they appear to come from dreams.

Thus, a gentleman, who had for several days been singu-
lar in his behaviora, woke in the niglit and imagined that he
saw his wife standing by his bedside with a phial of prussic
acid which she was about to empty into his mouth. The
hallucination took such strong hold of him that he went

346

DISEASES OF THE BEAIX.

into the adjoining room, where his wife slept, to see if slie
were there or not, and, though he found her sleeping quietly,
he awoke her, and accused her of having attempted to poi-
son him. No amount of argument or persuasion could eradi-
cate the false belief from his mind.

Another for several days had been siDcnding money very
freely in articles of little or no use to him, when one morn-
ing he announced to his family that for several days he had
been thinking a great mistake had been committed in his
conception, and that his soul had got into the wrong body.
He was therefore convinced that he was not the man he
should have been, and hence he had done a great many
things which were altogether repugnant to his physical
senses. So long as the antagonism continued between his
mind and his body, there was no hope of any happiness for
him in this world. In this case there had never been any
hallucination or illusions of any of the senses. The delusion
was therefore entirely the result of the patient's own per-
verted thoughts.

When rapidly following each other, delusions are clearly
spontaneous — are not the result of any series of thoughts,
but come on the spur of the moment and upon very slight
suggestions. As they are readily formed, they are not fixed
in character. A lady, for instance, after receiving some
very sorrowful intelligence relative to her husband, im-
agined that she had lost her eyesight. For a few hours she
remained with her eyes shut, alleging that there were two
deep cavities behind the lids. Suddenly she opened them,
said she saw perfectly well, but that the top of her head had
been cut off, and this was almost immediately changed to
the belief that she was perishing with cold, and so on, no
one delusion lasting longer than a few minutes. In many
cases like this the erroneous beliefs are excited by sensations
in various parts of the body, but this was pot so in the pres-
ent instance.

The connection between dreams and insanity is very

INSANITY.

347

close. Most of US have at times had such vivid dreams that
they have been removed from our minds with difficulty.
There appears to be no doubt that many of the delusions of
the insane have dreams for their cause.

The delusions of the insane are, in the great majority
of cases, connected more or less directly with themselves.
Thus a person believes that his leg is made of glass, that his
head is reversed on his shoulders, tliat he is some great per-
sonage, that a large fortune has been left to him, or that
some misfortune has deprived him of his property or his
friends. He will often reason logically and forcibly from
the premises he has assumed, and will give no evidence of
insanity outside of his delusion. Such cases are embraced
under the term of reasoning mania, and the skill and acu-
men exhibited by persons thus affected are often surprising.
When it is important, in their estimation, for them to con-
ceal their delusions, they will often do so for a long time,
and stratagems of various kinds are necessary to their
speedy detection. Sooner or later, however, the delusion
comes out.

The designation monomania can properly be applied to
many of the cases of intellectual insanity. In the uncom-
plicated form of the disease it is rare, after it is fully estab-
lished, that more than a single object, or a small class of
objects, are the subjects of the delusions.

The delusions of the insane may be comprehended under
two categories — those which are of a pleasant or exalted
character, and those which are unpleasant or morbid.
These usually leave their impress on the countenance of the
patient, and his actions and manner are in accordance with
them.

It would be strange if this were not the case. The only
guide which man has for his actions is his reason. He
weighs arguments and motives, and determines according
to the bearing which they may have on his mental processes.
A delusion is, in many cases, simply a false premiss ; the

348

DISEASES OF THE BRAIN.

conclusions whicli the individual draws from it are entirely
logical. Taking, for instance, the case of the gentleman
who had imbibed the idea that his wife had attempted to
poison him ; and, admitting that he was correct in this no-
tion, his subsequent conduct — his denunciations, his refusal
to live with her, his efforts to have her imprisoned, etc. — is
perfectly reasonable. The line of conduct was such as most
men would have pursued under like circumstances. In such
cases, therefore, there is no fault in the intellectual processes
after the first step is taken. It is this first step which con-
stitutes the disease — it is the delusion which enslaves the
mind.

Intellectual insanity is often uncomplicated by any other
form of mental derangement. There are no illusions, no
hallucinations, no overpowering influence of the emotions,
and no loss of control over the will. Even when the de-
lusion is of such a character as apparently to be connected
with some one of the senses, and thus to be based upon a
false perception, full inquiry will often show that there is
no error of the sensorial processes, centric or eccentric.
Thus, a lady under my care had the delusion that she had
lost her palate, as she called it. I held a mirror to her face,
and, while she opened her mouth, I pointed out to her that
all the parts were present. " Yes," she replied, " I see all
that ; the form is there, I know very well, but the substance
is gone ; " and no arguments could convince her to the con-
trary. A gentleman conceived that his right hand was
made of glass, and therefore, to prevent its being broken, he
kept it carefully enclosed in a stout case made to fit it
accurately. On my calling his attention to the physical
qualities of his hand, and pointing out how they diftered
from those of glass, he said: "I once thought just as you do.
My brain was then incapable of appreciating minute differ-
ences as well as it can now ; and, though I confess that my
senses still convey to me the idea that my hand is like other
2)eople's, yet I know the conception is erroneous, and I cor-

INSANITY.

349

rect it at once by my reason. My hand looks like flesli and
blood, but it is glass for all that. Nothing is more calcu-
lated to deceive than the senses."

Persons alfected with uncomplicated intellectual insanity
may go through the world without giving any considerable
evidence of mental derangement, unless the subject of their
delusions be touched upon. Still, there is no telling to
what extremes a delusion may carry its subject. Like a
sane idea, it may extend further with each day of life. A
person, for instance, imagines that he is the Emperor of
Russia. At first he does not comprehend the full impor-
tance of his supposed position, and, if of moderate reasoning
power, possessing deficient information, and naturally of a
quiet disposition, he may never go further than dressing
himself in some tawdry finery, and strutting pompously
through the wards of the hospital. But, under other cir-
cumstances, he reflects upon the greatness of his station, and
thus, from time to time, he conceives new ideas of his pow-
ers and importance, and may thus become a very trouble-
some patient. He comes to believe, perhaps, that he has
the power of life and death, and may attempt to exercise
his imaginary prerogative.

Delusions in regard to relatives and friends are very
common, and hence the conduct of the person entertaining
them is changed as it relates to the objects of his erroneous
ideas. It is a usual thing, therefore, for such an insane per-
son to disinherit those who would naturally be heirs of his
property. This point is of importance in its medico-legal
relations.

Delusions may be of such a character as to affect the
emotions secondarily. A very common delusion is that of
having committed the unpardonable sin, and accordingly the
patient suffers great emotional disturbance. This influence
upon the emotions is perfectly natural and logical, for, if
the person really had committed a sin for which there is no
hope of pardon, and had thus incurred the punishment of

350

DISEASES OF THE BRAIN.

eternal damnation, it would be strange if tlie emotions of
sorrow and despair were not excited into activity. Such
cases, however, are not to be embraced under the head of
emotional insanity ; and, though at first sight they may ap-
pear to be of that type, inquiry will reveal the fact of the
preexistence of the delusion.

Intellectual insanity is often the sequence of an attack
of acute mania, which form of mental aberration will be
presently considered.

I subjoin the accompanying portrait, engraved from a

Fig. 12.

photograph, of a typical case of intellectual insanity. The
patient was, for many years, an inmate of the New York

INSANITY.

351

City Lunatic Asylum on Blackwell's Island. Her delusion
was, that she was the wife of the late President Buchanan.
She assumed his name, and was exceedingly tenacious of
her rights and dignities. All visitors were received by her
with as much formality as though she were the real mistress
of the White House. It will be seen, upon examination,
that there is no trace of emotional disturbance to be per-
ceived in her countenance. The expression of her face is
intelligent and shrewd, and she might have walked Broad-
way every day of her life without exhibiting as much evi-
dence of insanity as many of those who perambulate that
thoroughfare and are considered perfectly sane.

III. — Emotional Insanity.

The emotions are at all times difficult to control, but
they may acquire 'such undue prominence as to dominate
over the intellect and the will, and assume the entire mas-
tery of the actions in one or more respects. This effect may
be produced suddenly, from the action of some cause capable
of disturbing the normal balance which exists among the
several parts of the mind, or it may result from influences
which act slowly but with gradually-increasing effect. In
either case there is not necessarily either delusion or error
of judgment, but it very generally happens that the intel-
lect sooner or later becomes involved.

Emotional insanity may be produced without there being
any discoverable cause, and without the patient being able
to allege a motive.

Some emotions are more frequently disordered than
others. Those of a sorrowful cliaracter are preeminent in
this respect, and, when they are affected, the type of insanity
called melancholia is the result. This may be either acute
or chronic in its course. The first is rarely uncomplicated,
and hence will be more properly considered under the head
of mania.

Homicide, suicide, and other crimes, may be the result

352

DISEASES OF THE BRAIN.

of emotional disturbance as well as of intellectual insanity.
The most common of these is undoubtedly suicide, the in-
dividual committing self-destruction in order to escape from
the depressing influences which act upon him. It more fre-
quently happens, however, that the emotions are disordered
through the morbid operations of the intellect. A person,
for instance, to cite the example previously given, imbibes
the delusion that he has committed the unpardonable sin, or
that God has deserted him, and, in consequence, passes into
a condition of settled melancholy, during which he may at-
tempt self-destruction to escape from his harrowing thoughts,
or commit a homicide, in order that the same end may be ac-
complished by his being hanged for murder. Other emotions
may of course be excited into morbid activity by derange-
ment of the intellect. Delusional jealousy, anger, hatred,
or love, may thus urge their unfortunate victim to the per-
petration of crime, plunge him into a depth of unhappiness
from which there is no escape, or lift him into an ecstasy of
bliss far exceeding that derivable from the realization of all
his wishes.

Under the head of moral insanity, Dr. Prichard, several
years ago, described a form of mental derangement which
embraced several species which are now more properly
placed under other heads. Several of these are clearly emo-
tional in character, and most of them relate to altered modes
of feeling or of the affective faculties, and therefore, in the
largest sense of the word, may also be called emotional.
Careful and thorough inquiry will, however, often show that
the primary difficulty is one of defect, and not of aberration
or exaggeration, and that, therefore, these instances of defi-
cient moral sense, leading the subjects to the perpetration
of crimes of various kinds, should be classed under the head
of imbecility.

Many cases of what are called temporary insanity, mania
ephemera, transitory mania, and morbid impulse, are really
instances of emotional insanity. That such a condition ex-

INSANITY.

353

ists there can be no doubt, and it is important, both as re-
gards the subject and society, to be able to recognize or to
disprove its presence.* A few words, therefore, on this
point, will not be out of place.

The state with which transitory emotional insanity is most
apt to be confounded is that which has been designated heat
of passion. Passion is emotional activity. It refers to that
mode of the mind in which certain impressions or emotions
are felt, and which is accompanied by a tendency or impulse,
often in*esistible, to act in accordance with these impres-
sions or emotions irrespective of the intellect. An act per-
formed in the heat of passion is one prompted by an emo'
tion which for the moment controls the will, the intellect
not being called into action. It is an act, therefore, per-
formed without reflection. The passions are, to a certain
extent, under the control of the will, and this power of
checking their manifestations is capable of being greatly in-
creased by self-discipline. Some persons hold their passions
in entire subjugation, others are led away by very slight
emotional disturbances. The law recognizes the natural
weakness of man in this respect, and wisely discriminates
between acts done after due reflection and those committed
in the midst of passional excitement.

The acts performed during temporary emotional in-
sanity, in their more obvious aspects, and when viewed iso-
latedly, resemble those done in the heat of passion. But
they are so only as regards the acts themselves. Thus a per-
son, entering a room at the very moment when one man was
in the act of shooting another, would be unable to tell
whether the homicide was done in the heat of passion, or
under the influence of an attack of temporary insanity ; he
would be equally unable to say whether it was committed
with malice aforethought or in self-defence. The act, there-

' The best monograph on temporary insanity with which I am acquainted is
that of Krafft-Ebing, Die Lehre von der Mania Transitoria, fiir Aerzte und Ju-
risten dargestelt. Erlangen, 1865.
23

354

DISEASES OF THE BRAIN.

fore, by itself, can teacli us nothing. We must look to the
attending circumstances, and to the antecedents of the per-
petrator, for the facts which are to enlighten us as to the
state of mind of the actor. Now, the conditions of tempo-
rary emotional insanity are so well marked that the act
which indicates the height of the paroxysm may almost be
disregarded, for it is always preceded by symptoms of men-
tal aberration, while acts done in the heat of passion are not
thus foreshadowed.

And, as regards the subsequent state of the individual,
the distinction is equally apparent. The one who has com-
mitted a criminal act in the heat of passion soon subsides
to his ordinary condition of equanimity, and generally be-
gins to think of his safety. The one who has perpetrated a
similar act during an attack of temporary emotional in-
sanity never thinks of escape, nor even avoids publicity.
He may even boast of his conduct, or deliver himself into the
hands of the law. What is, however, of greater importance
is the fact that, though he may subside into a condition of
comparative sanity, the evidences of disease are still present,
and remain in him for days, weeks, or even months and
years. These symptoms are generally those of cerebral con-
gestion, to which attention has already been directed.

In heat of passion, the act follows immediately on the
excitation of which it is the logical sequence. In temporary
insanity, the act is the culmination of a series of disordered
physical and mental manifestations, and may or may not be
in relation with the emotional cause. The distinction is,
therefore, clear and precise. The case of Henriette Cornier,
so fully detailed by Georget,* is a striking instance of the
action of emotional disturbance and morbid impulse. This
woman was twenty-seven years, of age, was of a joyous dis-
position and gentle in her ways, and particularly fond of
young children.

In June, 1825, a notable change ensued in her ; she be-
1 Discussion M6dico-Legale sur le Folie, ou Alienation Mentale, Paris, 182G.

INSANITY.

355

came sedate, seldom laughed, sighed often, was taciturn, and
neglectful of her work. She was accordingly discharged
from her service as domestic, and returned to her friends.
She soon afterward made an attempt at suicide by throwing
herself from the parapet of a bridge, but was prevented.

She then entered the service of a Madame Fournier, still
being disposed to melancholy, notwithstanding all efforts
made to restore her.

On the 4th of November, her mistress went out, leav-
ing Henriette at her work, and directing her to go to a shop
kept by a woman named Belon, and get some cheese. This
woman had a very beautiful little daughter not two years
old, for whom Henriette had always manifested a great lik-
ing. On this occasion she fondled the child as usual, and
persuaded her mother to let her take it out to walk. Hen-
riette took the child to Madame Fournier's house, and, go-
ing first to the kitchen, obtained a large knife, with which,
and the child, she went to her own room. On the stair-
case she met the porteress, and, before her, embraced with
every evidence of love the little child she held in her arms.
Arrived at her own chamber, she laid the infant on its back
on the bed, and, seizing its head with one hand, she with the
other drew the knife rapidly across the neck and severed
the head from the body before her victim could utter a cry.
Before, during, and after this crime, she had, as she de-
clared, no emotion or feeling of horror. On the contrary,
she was calm, collected, felt neither pleasure nor sorrow, but
apparently acted mechanically.

Two hours afterward the mother came for her child ;
Henriette stood at tbe door. " Your child is dead," she ex-
claimed, and then, entering the room, seized the head of the
murdered infant and threw it into the street.

On the arrival of the officers, she was found sitting in
the room with the dead body, gazing at it, her hands covered
with blood and the knife near her. She did not deny her
crime, and exhibited neither penitence nor remorse. "I in-

356

DISEASES OF THE BRAIN.

tended to kill it," she said, and, on being further interro-
gated, declared that she had no particular motive ; that she
had experienced the inclination, and she was destined to
perpetrate the act.

She was suspected of insanity, and was examined by a
commission consisting of Adelon, Esquirol, and Leveille, who
reported that they were unable to determine whether she
was sane or not. This report not being satisfactory, a sec-
ond examination was ordered, but still no definite opinion
could be obtained from the commission. She was tried and
found guilty, very illogically, of voluntary but unpremedi-
tated homicide, and was sentenced to hard labor for life.

Fig. 13.

The above likeness (Fig. 13) is that ot a woman affected

INSANITY.

357

with pure emotional insanity, of a depressing character, but
without dehisions of any kind. She could assign no cause
for the intense melancholy with which she was affected, and
which caused her to pass the greater part of the day crying
and wringing her hands. She had twice attempted suicide
before she came under my care, not from any delusion, but
solely that she might escape from her overpowering emo-
tions and the mental anguish they caused her. She was
fully sensible of her situation, knew how groundless was her
grief, and constantly lamented her inability to control her
feelings.

IV. —Volitional Insanity.

In uncomplicated volitional insanity, there are no delu-
sions and no emotional disturbance, but solely an inability
to exert the will in accordance with the intellect. Many
cases of morbid impulse are instances of volitional insanity,
in which an idea suddenly flashing across the mind is imme-
diately carried out by the individual, although his intellect
and his emotions are strongly exerted against it. Thus, a
person who previously has not exhibited any very obvious
symptoms of mental derangement — though careful inquiry
will invariably show that slight evidences of cerebral disease
have been present for some days — instantaneously feels a
morbid impulse to commit a murder or perpetrate some
other criminal act, and is forced to yield, notwithstanding
all the efforts he may make. Numerous cases of the kind
are on record.

Thus Esquirol ' relates the case of a man thirty-two years
old, of a nervous temperament and quiet disposition, wlio
had been well educated, and who was fond of the fine arts.
He had suffered from a brain-disorder, but had been several
months cured. After being in Paris for about two months,
during which time he led a perfectly regular life, he one
day entered the Palais de Justice and attacked an advocate

» Des Maladies Ment. Paris, 1838, t. i., p. 380.

358

DISEASES OF THE BRAIN.

with great furj. The next morning, when seen by Esquirol,
he was perfectly tranquil and composed, showed no anger
whatever, and had slept well all night. The same day he
designed a landscape. He recollected what he had done the
previous day, and spoke of it with coolness. He declared
that he had entertained no ill-will against the advocate, had
never even seen him before, and had no business with him
or any other lawyer. He could not understand, he said,
what had actuated him to make the assault. Subsequently
he exhibited no indications whatever of being insane.

Many instances of the so-called moral insanity may prop-
erly be placed under the head of volitional insanity, for they,
are characterized by an inability to so exert the will as to
refrain from the perpetration of acts known to be crimes. Of
such are cases of kleptomania, dipsomania, pyromania, etc.

The will in insanity is often secondarily alfected through
disturbance originating in the intellect or the emotions, and
acts are hence performed which give evidence of the exist-
ence of mental aberration. In mania of all kinds, and es-
pecially in dementia and general paralysis, there is either a
loss of volitional control, or an inability to exert the normal
will-power.

y. — Mania.

In mania the mind is affected in several, generally all
of its parts. There are illusions, hallucinations, delusions,
emotional disturbance, and loss of volitional power or control.
The patient is either morbidly excited or depressed, and is
often violent in his language and actions. Acute mania is
the more common species of mental aberration, and in its
two types of exaltation and depression constitutes the form
which it is most important for the physician to understand.
I shall therefore consider them at some length, so far as their
symptoms and cause are concerned.

Acute mania with exaltation has its prodromatic stage,
the symptoms of which are very similar to those which pre-

INSANITY.

359

cede an attack of fully-developed cerebral congestion. These
in the main are pain or fulness in the head, confusion of
ideas, increased irritability of the mind, and, above all, wake-
fulness. In addition, there are restlessness of body and a
singularity of behavior, which strike those thrown into in-
timate relations with the subject, and cause them to suspect
that something is wrong with him.

The character and disposition undergo a change, and
it is very common for unfounded prejudices to be formed
against persons formerly highly esteemed.

Before very long there are illusions and hallucinations.
At first the patient struggles against them, but eventually
he accepts them as true, and hence becomes subject to delu-
sions. These are rarely fixed in the earlier stages, and may
not be so through the whole course of the disorder.

With these symptoms there are evidences of derangement
in other organs besides the brain. Thus, the appetite is less-
ened, the bowels are torpid, the kidneys fail to eliminate the
normal quantity of urine, the heart becomes irregular in its
action and beats with increased frequency, a certain sign of
a weak and excited nervous system, and the skin is either
bathed in perspiration or is dry and hard.

With the full development of the disorder the patient be-
comes incoherent and rambling, showing a great disposition
to talk, to laugh, and to sing, and indulging in antics of
various kinds. His delusions mainly have reference to him-
self : he imagines that he is some great personage, that he
has suddenly become very rich, or that he has been specially
singled out for some other piece of good fortune.

Not unfrequently he is exceedingly troublesome, destroy-
ing the furniture of his room, tearing his clothes, attacking
those around him, and making all kinds of attempts to es-
cape from restraint, but at the same time there is rarely any
serious effort to do great bodily harm either to himself or
others. Sometimes, however — and this fact should always
be born in mind by the attendants — there is a disposition to

360

DISEASES OF THE BRAIN.

perpetrate acts of extreme violence, and such a tendency,
even when not previously manifested, may very suddenly
be developed.

Thus, a lady under my care, who had a few days before
become insane, behaved with propriety, merely making
continual efforts to get into the street to attend court, where,
as she believed, she had an important lawsuit. Without
any warning, however, she went into an adjoining room
where her infant child was sleeping, and threw it out of the
window before she could be stopped in her act, exclaiming :
" Well, if I can't go out. my baby shall." Fortunately, the
child fell on a thick grape-vine, and was not injured.

In another gentleman, whom I saw in consulta-

tion with my friend the late Prof. George T. Elliot, became
affected with acute mania of the most hilarious and exalted
character. While playing on the piano and singing with
the utmost glee, he expressed a wish for a cracker, and
went to the dining-room to get one. While apparently look-
ing for something to eat, he suddenly seized a knife and at-
tempted to cut his throat. The close proximity of his attend-
ant alone prevented his inflicting serious injury on himself.

As a rule, patients with acute mania lose all sense of
decency, and become exceedingly filthy in their habits and
obscene in their language and conduct.

At times such lunatics exhibit a surprising degree of
cunning, and are able to exercise great control over their
conduct when they have an end to accomplish. They may
thus readily deceive the young and inexperienced physician,
and induce him to forego the idea of putting them under
permanent restraint, or they may so impose on him as to
induce him to relax his vigilance, and thus allow of their
committing some outrageous act.

It must be remembered that acute mania is not suddenly
cured, but runs a definite and allotted course.

It is rare that the memory of the patient suffers to any
considerable extent in acute mania. The patients are per-

INSANITY.

361

fectly conscious of their surroundings, and are seldom de-
ceived by the subterfuge so frequently and so unjustifiably
employed that they are to be taken to a hotel or a country-
seat when about to depart for an asylum. If the stratagem
does for the moment impose upon them, they recollect the
fraud, and will not again repose confidence in those who
have perpetrated it.

Their appetites are generally unchanged. If in the
habit of smoking or drinking, they still want their tobacco
and their wine, and are usually able to eat a full allowance
of food.

After their entrance into the asylum, the main object ot
their lives is to get out again as soon as possible. They often
recognize their condition, and will call attention to any in-
dications of improvement they may exhibit. They are not
for a moment deceived by the delusions of their fellow-luna-
tics. Doctor," said a patient to me whom I had sent to a
lunatic asylum, and was visiting, " this is the best place in
which to study the infirmities and humbugs of human na-
ture of which I have any knowledge. Everybody here is
insane except myself. There is a fellow I used to know be-
fore he lost his mind, a good, clever fellow he was too, and
as sharp as a steel trap. I^ow he is a d — d fool, and thinks
he takes his breakfast off the top of the capitol every morn-
ing. And there is a lady holding that bunch of rags to her
breast and thinking it's a baby. These lunatics are funny,
very funny, but I've had about enough of them, and would
like to go somewhere else." At the time this gentleman
thought he was General Grant, and was going to be inaugu-
rated President in a few days.

It is rarely the case that the sleep is regular and sound.
Often they will lie awake all night, talking of their plans,
or else will annoy their attendants in every conceivable
way. Although having usually uncomfortable feelings in
the head, they rarely suffer from acute pain in that part of
the body.

362

DISEASES OF THE BRAIN.

The accompanying woodcut represents a case of acute
mania, with general mental exaltation. No one can fail to
perceive the expression of happiness on the face.

Fig. 14.

Acute Mania, with Depression. — The acute melanchoh'a
of many autliors is a very terrible form of mental aberration.
Like that just described, it is generally preceded by prodro-
mata, which indicate, by their character, the type of insan-
ity which is about to be developed, but it often appears
with great suddenness. In the ease of a lady now under
my charge, the first evidence of mental disorder was a vio-
lent scream, due to the fact that an idea had instantaneously

INSANITY.

363

flashed through her mind that she had committed tlie un-
pardonable sin, and had consequently lost all hope of saving
her soul. For several days she continued, with scarcely an
intermission, to scream, to cry, and to sob, at the same time
showing the greatest terror from the apprehension that the
devils were approaching her. Gradually this extreme state
became less violent, but she still continued to be actuated
by intense fear, and paced the floor night and day, wringing
her hands, weeping, and exclaiming, " Lost, lost, lost for-
ever ! "

In another case of a lady from the "West, the idea sud-
denly occurred to her that she was about to be killed. She
screamed, and begged, and prayed, to those around her not
to allow her to be injured. In the furniture and attendants
she saw her murderers, and to escape from them made sev-
eral attempts to throw herself out of the window. Then
she believed that she was to be poisoned, and refused all
food with the utmost pertinacity — closing her teeth so firm-
ly together that it was only by the use of all my strength
that I could succeed in prying them open.

Of all the forms of insanity, this is the one in which
illusions and hallucinations of the senses are most common.
These are particularly so as regards sight and hearing, and
do not, as a general thing, refer to the body of the patient —
although generally in direct relation with his delusion.

A gentleman, who, within a short period after becoming
affected with the present variety of insanity, came under
my care, was controlled by the delusion that he had com-
mitted so many sins that atonement must be made. He
had, therefore, several times attempted suicide, and, when I
entered the room where he was, he was in the act of strug-
gling with his friends, who were using all their strength to
prevent him throwing himself out of the window. As soon
as he saw me, he fell on his knees, held up his hands in the
attitude of prayer, and mumbled out a few words which
showed that he took me for a priest, and was asking for in

364

DISEASES OF THE BRAIN.

tercession with the offended Deity. On arriving at the asy-
lum, to which I recommended him to be immediately sent, he
went at once to an open coal-lire, and, before any one knew
what he was about, thrust his hand into the mass of burn-
ing coals, and succeeded in injuring it terribly.

Fig. 15.

In all cases of acute mania with depression, too great
care cannot be taken to prevent self-injury or suicide. It
must be constantly kept in mind that the idea is a very com-
mon one with this class of patients, and that frequently they
manifest great astuteness in concealing it till they are ready
to make the attempt.

INSANITY.

365

The physician, in general practice, should always urge
that patients affected with the form of insanity under con-
sideration should, as soon as possible, be placed in an asy-
lum, for it is almost impossible to manage them in ordinary
houses, or with their friends about them.

The preceding woodcut (Fig. 15) is an admirable like-
ness, taken from a photograph of a young woman in the
New York City Lunatic Asylum, suflfering from acute ma-
nia, with depression. Apprehension and terror are plainly
depicted on her countenance.

Fig. 16 represents a female inmate of the same asylum.

Fig. 16.

366

DISEASES OF THE BRAIN.

whose history I have not been able to obtain, but whose ex-
pression of countenance, though less pronounced than that
of the preceding, is nevertheless sufficiently indicative of the
existence of mania with depression.

VI. — General Paralysis.

The affection now known as general paralysis was first
described by Delaye,' in 1822 ; then by Bayle,* in the same
year; and then^with much more thoroughness and exactness,
by Calmeil,^ in 1826. It is a very common form of mental
derangement, and, aside from the implication of the mind,
presents the very striking feature of a gradually-advancing
paralysis, which derives its name of general from the fact
that it involves, sooner or later, nearly every muscle of the
body. This paralysis may show itself at the same time that
the insanity is manifested ; it may precede the mental de-
rangement, or it may be subsequent thereto. The latter is
much the more usual order.

The mental symptoms differ, in several important re-
spects, from those which occur in other forms of insanity.
The first indication of disease is generally an excessive
anxiety in regard to matters which are really of no great
importance. Of the cases which have come under my care,
one was first made apparent by a morbid apprehension on
the part of the patient that he was not managing some trust-
funds in the best possible way ; another by the idea that he
was constantly wounding the feelings of his friends; and
another was continually changing his mind about the
most trivial things, and apparently thinking that the world
watched, with great anxiety, all his movements.

At first the general mental type is that of depression.

' De la Paralysie G6n6rale Incomplete. Thhse de Paris, 1822.

* Recherches sur les Maladies Mentales, Paris, 1822 ; and Traite des Mala-
dies du Cerveau et des Membranes, Paris, 1826.

* De la Paralysie Consideree chez les Ali6n6s. Recherches faites dans le
service de feu M. Roger-Collard et de M. Esquirol, Paris, 1826.

INSANITY.

367

The emotions are easily excited, and the dehisions which
soon make their appearance are of the melancholic form.
The idea of propriety in the every-day acts of life seems to
be lost, and the patient will commit all kinds of indecent
acts without appearing to be aware that he is doing any
thing unusual. His memory fails rapidly, and his in-
tellectual vigor declines from the very first. Hence he is
not able to argue in defence of his delusions, but attacks
with physical force those who venture to differ with him.
His acts are in other respects eccentric and absurd. He
spends money in things which are of no manner of use to
him, and at the same time refuses to pay his small debts ;
he harasses in every possible way those who are about him,
gives them impossible orders, and then abuses them if they
are not at once obeyed ; he is whimsical at the table, his
likes and dislikes are changed, and he either eats and
drinks voraciously, or declares that nothing is cooked to
suit him, and leaves the table in a rage. Gradually the
form of his mental aberration changes ; he becomes more
cheerful, forms all kinds of impossible schemes for suddenly
acquiring great wealth, and these are quickly abandoned
for others equally impracticable. Thus delusion after de-
lusion rapidly succeeds each other, and these, in the great
majority of cases, relate to the grandeur, the wealth, the
physical strength, or some other great quality of the patient
constituting the delire des grandeurs of the French. One
will tell of his immense palaces built of gold and inlaid
with precious stones, and in the next breath will descant of
his great weight or his extreme lightness, or of the number
of children he has, or of the millions of operas he has com-
posed. Another urges his great importance in the political
world, tells us that he has elected all the members of Con-
gress himself, that he has paid off the national debt, and
that in consequence he is to be made Emperor of the United
States, with a salary of a thousand millions a year ; that he
is going to have a thousand physicians, who are to be clothed

368

DISEASES OF THE BRAIN.

in blue-velvet uniforms embroidered in gold and diamonds ;
that be bas cbartered tbe Great Eastern for a pleasure- trip,
and engaged ten tbousand musicians and a similar number
of ballet-dancers to go witb bim. Tbe next day be bas for-
gotten all tbese fancies, and is off on anotber series of absurd
ideas. In no respect is be restrained in tbe extent of bis
delusions. Impossibilities are not regarded. Wbile scarce-
ly able to drag one leg after tbe other, be will brag of bis
great fleetness of foot, and in tbe very deatb-grasp will mutter
about bis extreme strengtb and endurance.

Tbe symptoms connected with sensation are equally well
marked. In the early stage headache is often very severe,
so much so that, as Westphal ' bas remarked in bis excel-
lent monograph on tbe subject of general paralysis, tbe pa-
tient often dashes bis bead against tbe wall. At other times
the feeling in tbe bead is that of fulness or tightness, and
tbese sensations are often accompanied with vertigo. Neu-
ralgia in various parts of tbe body is common, and some of
my patients have complained of the different degrees of
numbness, especially in the bands and feet.

But still more strongly manifested are tbe disorders of
motility, due to tbe progressive paralysis. According to
my experience, the first sign of loss of power — one which is
very often observed before any evidence of mental derange-
ment is perceived — is a slight defect of articulation due to
paralysis of tbe lips. At first this is scarcely perceptible ;
there is merely a little trembling, an action such as that
seen in persons who are endeavoring to restrain their emo-
tions, but it is sufficient to give indistinctness to the utter-
ance of those words which contain lal)ial letters.

The tongue is the next to be affected. Examination
shows that there are fibrillary contractions of its muscles,
and it is moved with less facility. The articulation is slov-
enly, words are slurred over, and there are both stammering

' Ueber den gegenwartigen Standpunct der Kenntnisse von der allgemeinen
progressiven Paralyse der Irren. Griesinger's Archiv, Heft, i., p. 44.

INSANITY.

369

and stuttering. The patient notices these difficulties, and
in endeavoring to obviate them makes matters worse, by his
inability to be exact, contrasting strongly with his efforts.
The paralysis of the tongue gradually becomes more com-
plete, and at last this organ can only be moved with great
difficulty. The other facial muscles participate, and a blank,
somewhat sorrowful, expression is constantly present. The
voice loses its fulness, and there is difficulty of swallowing.

The muscles of the eye are also generally involved, pro-
ducing ptosis from paralysis of the levator palpebrse superi-
oris diplopia from implication of the internal rectus, and
contraction of the pupil — all of these efiects, except the last,
being due to difficulty existing at the point of origin, or in
the course of the third nerve. The pupils are often unequal,
and Austin ' declares with all seriousness that contraction
of the right pupil is associated with melancholic delusions,
and contraction of the left pupil with elation. Further in-
vestigation has not confirmed this theory. The gait of pa-
tients affected with general paralysis is very peculiar, and
is of two distinct kinds. In the one it is similar to that of
a person suffering from sclerosis of the posterior columns of
the spinal cord (locomotor ataxia). The feet are lifted high,
and are thrown down with a good deal of force, the heel
striking the ground first. As Westphal remarks, patients
with this gait cannot stand with the eyes shut and the feet
close together.

In the other kind the feet are scarcely lifted from the
ground, but are shuffled over it, and the action is somewhat
like that of a person attempting to balance himself on a
tight-rope. Patients with this gait can without difficulty
stand with the eyes shut.

As regards the upper extremities, the fingers lose their
strength and delicate coordinating power. The handwrit-
ing is shaky, and there is awkwardness in buttoning the

' A Practical Account of General Paralysis, its Mental and Physical Symp.
toms, Statistics, Causes, Seat, and Treatment, London, 1859, p. 31, e< seq.
24

370

DISEASES OF THE BRAIN.

clothing. The grip of the hand is still strong, but there is
an impossibility, as shown by the dynamograph, of main-
taining a continuous muscular contraction for even a few
seconds. The following is one of the tracings made by a
patient affected with the disease under consideration :

Fig. 17.

In analyzing this tracing, we see that it is not from
feebleness of the muscles that the line is descending, for
there are spasmodic elevations which show considerable
force. It proves, however, that, no matter at what point
the pencil is placed, the patient cannot keep it there.

The senses, with the exception of sight, do not often be-
come materially affected. Atrophy of the optic nerve causes
amaurosis or amblyopia. Ophthalmoscopic examination will
very generally detect this condition of the papilla at a very
early stage of the disease, together with retinal and choroidal
anaemia.

Convulsive seizures occur, and these are generally epi-
leptiform in character, though occasionally they are of the
nature of apoplexy. They vary greatly in character, some-
times resembling the petit mal of epilepsy ; at others, char-
acterized by strong convulsive movements or coma. Be-
sides these, there are attacks of complete paralysis of certain
muscles, or groups of muscles, which, however, rarely leave
any permanent effects, the usual degree of power being re-
gained in a few days.

INSANITY.

371

The course of general paralysis is often marked by peri-
ods of great improvement, and the patient's friends imagine
that he is certainly recovering. The symptoms, mental and
physical, all abate in violence, and may even disappear to
such an extent as not to be evident to general observers.
But the physician must not be deceived, for the ameliora-
tion is merely temporary, and sooner or later the disease re-
gains its former ascendency. At no time, even during the
height of the remission, is the mind of the patient in such a
condition as to admit of any considerable intellectual exer-
tion. There may be an absence of delusions, but the men-
tal weakness still exists.

Progressively this decline in the force of the mind be-
comes more strongly marked, until at last a condition of ex-
treme dementia is reached. Simultaneously the physical
power diminishes, until finally the patient, unable to walk, to
stand, or even to sit, is confined to the bed for the rest of his
existence. Bed-sores form, and deglutition becomes more
and more difficult. From this cause, the food may become
impacted in the fauces, and thus death produced by inter-
ruption to the respiratory process ; or the food may enter
the larynx. The sensibility of the lining membrane of the
cheeks and fauces is notably diminished, and hence the pa-
tient, in eating, goes on filling his mouth, not knowing that
he is doing so. "When he at last attempts to swallow, the
mass of food is greater than can pass down the oesophagus,
and, unless some one is near to assist him, he chokes to
death.

Death may otherwise take place from a gradual cessa-
tion of the respiratory process, or from sheer exhaustion.

The duration of general paralysis is variable. Some-
times death results in a few months, and at others it may be
deferred for five or six years. The average period is about
three years. General paralysis is not likely to be confound-
ed with any other affection than chronic alcoholic intoxica-
tion, from which the history of the case and its general

372

DISEASES OF THE BRAIN.

progress will suffice to distinguish it. With lead paralysis
it has scarcely any features in common.

General paralysis is almost invariably fatal. A few cases
of recovery have been reported, but there is room for doubt-
ing that most of them were actual cases of the disease, and
the others were probably, as Griesinger suggests, instances
in which the remission was long. A complete recovery in

Fig. 18.

which the patient has been able to resume his ordinary oc-
cupation, and to exert his natural mental and physical pow-
ers, has certainly not come under my notice. At the same
time, recognizing the skill brought to bear upon modern
medical science, I do not despair of eventually being able to
give a more hopeful statement. That the life of the patient

INSANITY. 373

can be prolonged and his condition improved by judicious
management I am v^ery sure.

The preceding cut (Fig. 18), wliich I take from Tuke
and Bucknill's " Manual of Psychological Medicine," gives
a more typical representation of the face of a patient suffer-
ing from general paralysis than any I liave been able to
tind elsewhere.

YI. — Idiocy and Dementia.
The subject of idiocy does not come within the scope of

Pig. 19.

the present work, and I merely mention it as an element in
the classilication I have proposed. The treatment of those

374 DISEASES OF THE BRAIN.

SO unfortunate as to be originally weak-minded, is a particu-
lar branch of medical science which requires special train-
ing, and which could not be sufficiently considered in any
of its relations in a work intended for the general practi-
tioner. There is not so much to cure in an idiot, as there
is to develop. As an illustration of the facial expression
and general appearance of an extremely idiotic person, I give
the preceding likeness of a young man (Fig. 19) in the New
York City institution on Randall's Island. "When I first
saw this individual several years ago — when the photograph
was taken — he was filthy in his habits, and had not as high
a degree of intelligence as a well-trained dog. Through
persevering eflPorts on the part of his instructors, he has be-
come neat in his person, has learned to say a few words, and
is altogether more advanced intellectually than he was at
the time mentioned. His cranial development is, however,
so small that any very material progress is not to be ex-
pected.*

Dementia. — Dementia may be primary, but such is very
rarely the case, it being in the vast majority of instances the
consequence of an acute attack of insanity, or incident to
old age.

The characteristic feature of dementia is mental weak-
ness, and this is shown as regards the emotions, the intel-
lect, and the will. The former are not held under control,
slight matters bring them into inordinate action, and tears
are shed, and laughter excited, when there is neither ade-
quate cause for one or the other. The intellect is affected
in all its parts. The power of application, or of fixing the
attention, is materially lessened, and this is doubtless one
reason why imperfect ideas are formed of very simple mat-

' For full information on the subject of idiocy, the reader is referred to
Idiocy and its Treatment by the Physiological Method, by Edward Seguin, M.
D., New York, 1866, and a Manual for the Classification, Training, and Educa-
tion of the Feeble-Minded, Imbecile, and Idiotic, by P. Martin Duncan, M. D.,
and William Willard, London, 1866.

INSANITY.

375

ters, and why it is so difficult to conceive a series of con-
nected thoughts. The memory, especially for recent events,
is weakened to an extreme degree, and the delusions of the
patient, if still present, are constantly undergoing change
from the impossibility of recollecting them. Volition is al-
most entirely abolished. The patient is altogether con-
trolled by others, the idea of olfering opposition to their
wishes never entering his mind.

Fig. 20.

The facial expression of a patient affected with dementia
is not always characteristic, and this mainly for the reason
that the physical health is generally good. The deficiency
of mental power is, however, readily perceived in the ma-

376

DISEASES OF THE BRAIN.

jority of cases, when the attempt is made to excite the
brain to action. The failure of the face to respond to the
ideas sought to be conveyed becomes very evident.

An excellent representation of a patient affected with
dementia is given in the preceding woodcut (Fig. 20).

Having thus very cursorily considered the symptoms
and course of insanity in its several forms, I come in the
next place to the discussion of certain points common to all
the varieties. In so doing I shall still refer only to general
principles.

Causes. — Among the causes inherent in the individual,
none is so powerful in its action as hereditary tendency.
This may show itself not only by the fact that ancestors
have been insane, but that insanity in the descendants may
have resulted from hysteria, epilepsy, catalepsy, or some
other general nervous affection in them. It often happens,
too, that the disease, like many others known to be hered-
itary, skips a generation.

Insanity is more common in males than in females,
though the difference is not so great as many suppose.

The period of life between twenty-five and forty-five is
that at which insanity is most liable to make its appearance.
Cases are on record of infants having manifested unequivo-
cal symptoms of mental aberration, but the affection is not
often met with under the age of puberty.

The civil condition of the individual, as regards marriage
or celibacy, exercises an effect over the causation of insanity.
Statistics show that celibates of both sexes are more liable
than the married. So far as males are concerned, this result
is probably due to the fact that in celibacy, as a rule, the
mode of life is more irregular. Insanity is assuredly more
common among civilized than uncivilized nations, but, as
regards the different classes of individuals wlio go to make
up a civilized community, it is very certain that the i-efined,
educated, and wealthy classes, are not so liable to insanity as
the lower orders. The exciting causes are both moral and

INSANITY.

377

physical. Of the former, emotional disturbance, grief, ter-
ror, disappointed affection, anxiety, great joy, etc., stand
first in influence. It is doubtful if moderate intellectual
exertion ever, of itself, causes insanity. It is only when the
brain is worked night and day, to the deprivation of sleep,
and without sutficient change, that insanity results from
mental labor. Continual thinking on one subject is the
most effectual way of producing insanity by the action of
the brain.

Among the physical causes, drunkenness, the use of
opium and other narcotics, excessive venereal indulgence,
masturbation, blows on the head, exposure to severe heat or
cold, the puerperal state, and certain diseases, may be re-
ferred to.

Diagnosis. — The principal point to be considered under
this head is the discrimination of the real from the feisned
disease. The necessity for making the distinction, generally
arises from the simulation of insanity by criminals. Such
pretenders are, in general, discovered without difficulty,
from the facts that they overact their parts, are not pos-
sessed of sufficient knowledge to carry out the fraud con-
sistently, and are deficient in the perseverance and force of
character requisite to success.

The antecedents of the individual must be carefully in-
quired into, as well as his actual condition. Watching him
when he thinks he is not observed, and the administration
of ether by inhalation, will generally suffice to expose the
pretender.^

Prognosis. — This depends very greatly upon the form of
insanity present, and upon the possibility of procuring suit-
able treatment. Acute mania, with depression, general pa-
ralysis, and dementia, are the most unfavorable types with
which we have to deal. Either of the uncomplicated forms,

^ For an exellent monograph on this subject, the reader is referred to
^tude Medico-Legale sur le simulation de la Folie, par le Docteur Armand Lau-
rent, Paris, 1866.

3Y8

DISEASES OF THE BRAIN.

or acute mania with exaltation, is much more readily cured.
The older the patient when the disease appears, the more
unfavorable the prognosis for all ages over puberty, except
for very early life. The existence of hereditary tendency,
and the habit of using alcohol and other narcotic substances
to excess, likewise lessen the prospect of recovery.

Morbid Anatomy and Pathology. — The fact that after death,
in cases of insanity, no appearances are to be found within
the cranium to which the disease existing during life could
fairly be attributed, is no proof of the absence of changes
from the normal condition. The difficulty may be with the
blood circulating through the brain, and in the inadequacy
of our means of examination, and it is well known that we
are as yet scarcely on the threshold of inquiry into altera-
tions of cellular structure, only discoverable by careful prep-
aration of the nervous tissue, and through microscopical
examination. Still, even with all these unfavorable circum-
stances, in the great majority of fatal cases of insanity pal-
pable deviations from the normal structure are observed.
One fact may be considered as established, and that is, that
the morbid alterations are by preference found in the mem-
branes and cortical substance of the brain, and that those
changes are the result of congestion and inflammation.
Thus there are thickening and opacity of the membranes,
adhesions, effusion of serum, and softening of the cortical
substance. Histologically the changes are those of defective
nutrition and degeneration — ^leading to the formation of
connective tissue in superabundance at the expense of the
nervous substance, and the degradation of this latter into
fat, amyloid bodies, pigment, etc.

The pathology of insanity is readily deducible from the
morbid anatomy, and from an attentive consideration of
the symptoms observed during life. Many cases, especially
those of temporary insanity, are clearly the result of con-
gestion, and others, such as those of acute mania, owe their
first and most prominent symptoms to a like cause. In

INSANITY.

379

other cases, exhaustion of the brain-tissue is the immediate
cause. From excessive use, and insufficient repair, there is
actually what may be called a chemical atrophy of the cere-
bral substance, and healthy brain-action is, moreover, in such
cases generally rendered much more difficult from the fact
that the products of nerve disintegration are not removed.

Insanity is often the result of alterations in the normal
qualities of the blood. The influence of many substances
in producing mental aberration is well known, and there is
no doubt that their power is, to a great extent, due to their
entrance into the blood, and their consequent circulation
through the cerebral vessels. Among these, alcohol, opium,
Indian hemp, belladonna, and bromide of potassium, may
be mentioned. I have, in a memoir ' upon the subject, cited
several cases of positive mania caused by the excessive use
of bromide of potassium. The accumulation of either urea
or bile in the blood is well known to produce mental de-
rangement, and there is no doubt that other morbid agents,
such, for instance, as malaria and the poison of typhus, will
give rise to a like result. Irritations in different parts of
the body may, by reflex action, give rise to insanity. The
influence is probably exerted through the sympathetic nerve
on the vaso-motor nerves. I have seen two cases of acute
mania caused by worms in the alimentary canal, and one by
indigestible substances. Temporary insanity is frequently
the result of such causes.

The insanity of women generally has a reflex origin.
The so-called puerperal mania is a variety which differs in
no essential respect from ordinary cases of acute mania.
Irritations of the genital organs, especially of the ovaries,
may give rise to all the forms of insanity mentioned, with
the exception, perhaps, of general paralysis. A few weeks
ago I was consulted in the case of a lady who had become

* On some of the Effects of the Bromide of Potassium, when administered
in Large Doses, Journal of Psychological Medicine, January, 1869, vol. iii.,
p. 46.

380

DISEASES or THE BRAIN.

insane clearly from the irritation caused by chronic metritis.
A more marked case of acute mania, with depression, and a
more determined disposition to suicide, I have rarely wit-
nessed.^ In these cases of blood-poisoning and reflex irrita-
tion it is not to be expected that morbid changes will gen-
erally be discovered in either the brain or its membranes.
Occasionally, however, such alterations are eventually pro-
duced.

Treatment. — The fact is daily becoming more evident
and more generally admitted that insanity is to be treated
as a material disease, and not as a metaphysical nonentity.
It is therefore incumbent on the general practitioner to
make himself acquainted with the principles involved in the
pathology and treatment of the very important class of dis-
eases now under consideration. Besides, although he may
not have the facilities for continuing the treatment of insane
patients, he is called to them, in the first instance, at a time
when they are most susceptible of cure, and it is on his
opinion that measures as to personal restraint, or custody
of property, are taken. The first thing to do in the case of
an insane person is to provide competent attendance ; for,
as I have already said, there is no knowing to what extremes
his delusions or impulses may carry him. Even in the sim-
ple, uncomplicated cases of illusions and hallucinations, this
must be secured, for in an instant the false perceptions may
be accepted as realities, and acts performed in accordance
with them.

Then inquiry should be made as to the cause, and efibrts
directed to its removal. If this can be ascertained to be
eccentric, a good prospect of success may be entertained.

Examination should always be made with reference to
the state of the cerebral circulation, and here the ophthal-

' For a very full account of this important division of the subject, the reader
is referred to Die Beziehungen der krankhaften Zustande und Vorgiinge in
den Sexual-Organen des Weibes zu Geistesstorungen, by Dr. C. E. Louis Mayer,
Berlin, IS'ZO.

INSANITY.

381

moscope is capable of giving very definite indications. It
will very often be found that there is hypersemia of the
brain, and then the treatment recommended under the heads
of cerebral congestion and cerebral haemorrhage must be
carried out. Latterly I have used the bromide of lithium
in cases of acute mania, and have more reason to be satis-
fied with it than with any other medicine calculated to di-
minish the amount of blood in the cerebral vessels, and to
calm any nervous excitement that may be present. The
rapidity with which its effects are produced renders it spe-
cially applicable in such cases. The doses should be large
— as high as sixty grains or even more — and should be re-
peated every two or three hours till sleep be produced, or
at least till half a dozen doses be taken. After the patient
has once come under its influence, the remedy should be
continued in smaller doses, taken three or four times in the
day.

In cases of cerebral congestion attended with illusions
and hallucinations, but without mania, the other bromides
will answer the purpose — preferably the bromide of sodium.
They may also be given in the more violent forms if the
bromide of lithium cannot be obtained.

When the mental excitement is in a measure subdued,
and the patient sleeps reasonably well, the dilute phosphoric
acid of the pharmacopoeia is an admirable remedy for re-
storing strength to the exhausted system. It may be given
in doses of half a drachm, properly diluted with water, after
each meal.

Schroeder van der Kolk* has pointed out the efficacy
of aloetic purges in certain cases of emotional insanity of a
depressing character due to accumulations in the colon. I
have frequently had occasion to be gratified at the success
obtained. The aloes should be administered in doses of

' Die Pathologie und Therapie der Geisteskranken auf anatomisch physio-
logischer Grundlage, Braunschweig, 1863, p. 185, el seq.

Also translation by Dr. James T. Rudall, London, 18*70, p. 134.

382

DISEASES OF THE BRAIN.

about five grains three times a day. I am in the habit of
combining it with three grains of inspissated ox-gall, and
with excellent results. Under this very simple system of
medication I have frequently seen the most intense melan-
choly disappear in a few days.

In calming maniacal excitement I have occasionally used
opium. When it is necessary to obtain an immediate effect,
nothing can equal morphia hypodermically administered.
But its continuance, I am sure, is almost always productive
of bad results by increasing cerebral congestion. Indian
hemp, digitalis, and hyoscyamus, are occasionally useful. The
application of cold water, in the form of the douche, is a ra-
tional method of relieving intra-cranial hypersemia and mod-
erating nervous excitement. It should be used with caution.
The warm bath will also prove beneficial in some cases.

In general paralysis, whatever means of treatment are
employed should be used in the earliest stages to obtain the
greatest measure of success. I have several times derived
benefit from the use of the iodide of potassium in large
doses — not that it has cured, but that it has mitigated the
violence of the symptoms, and put some check to the ad-
vance of the disease. Liedesdorf * declares that, though he
has only used it himself in syphilitic cases, there is evidence
in favor of its utility as opposing some obstacle to the on-
ward course of the affection. He also recommends the cold
douche in all stages. In my own practice I have employed
phosphorus and strychnia with beneficial results.

In dementia, tonics and stimulants are generally useful.
Of the former, iron and quinine may be employed with ad-
vantage, and especially phosphorus, phosphoric acid, and
strychnia, the latter being combined with either of the
others.

A great many more remedies might be mentioned, and
in a work specially devoted to insanity I should call atten-
tion to them, but I have said enough to indicate the course

* Lehrbuch der psychischen Krankheiten, Eriangen, 1865, p. 229.

INSANITY.

383

of the treatment so far as medication goes.* There are a
few remarks yet to make under this head in regard to means
which, in my opinion, should not be used.

Counter-irritants are rarely if ever useful. I have never
seen any benefit derived from them.

General bloodletting is never necessary. It will calm
a highly-maniacal patient, but so will a sufiiciently severe
blow on the head.

The hydrate of chloral is a dangerous remedy. I have
seen it produce great increase in the maniacal excitement.
Its first efiect is always to augment cerebral congestion, and,
though it eventually lessens the amount of blood in the brain
and calms nervous irritability, the dose must be large for
these results to be obtained, and the same ends can be ac-
complished by safer means."

The moral treatment can only be effectually carried out
by secluding the patient from society at large, and especially
from his immediate family. It is not always necessary to
confine him in an asylum, but it is necessary in the great
majority of cases to place him in such a situation as will
secure for him safety, the companionship of sensible people,
and the influence and control of some one skilled in the
philosophy of the human mind, in the anatomy and physi-
ology of the brain and nervous system, and in medical sci-
ence generally. The great difficulty with asylums is, that
they contain only insane people, and the prevalent idea
among the public — and it is often carried out by the officers
of asylums — is, that institutions for the insane are simply
places in which dangerous or troublesome maniacs are to be
kept in safety. My own idea is, that the best of all places

' Of all writers on psychological medicine, no one seems to have more un-
bounded faith in drugging than Kieser — Elemente der Psychiatrik, Breslau und
Bonn, 1855.

' For my views on this subject, based on experiments, the reader is referred
to my memoir entitled : On the Physiological Effects and Therapeutical Uses of
the Hydrate of Chloral, New York Medical Journal, February, 1870, p. 469.

384

DISEASES OF THE BRAIN.

for a lunatic of any kind is the family of a physician, of
such a one as I have just mentioned. The association of
an insane person day after day, year after year, with others
similarly affected, with scarcely the least contact with peo-
ple of sound minds, is certainly in opposition to the first
principles of true psychological medicine.

Asylums are, however, for the present at least, necessary,
and it is with great pleasure that I am enabled to state, after
having visited a great many institutions for the insane in
Great Britain and on the Continent, that American asylums
are very far superior in every respect.

It has been said that it is useless to attempt to reason a
lunatic out of his delusion. Perhaps there is truth in this
when serious structural lesions exist in the brain. The false
intellectual conception is then a fixed result of the altered
brain-tissue, and is just as direct a consequence of cerebral
action as is a thouglit from a healthy brain. Still, we know
that in health it is sometimes possible by argument to coun-
teract the most firmly-rooted ideas, and there is no reason
why the same result may not occasionally be produced by
arguments addressed to a person with an insane mind. We
know, in fact, that this end is at times accomplished, and
that, by never for an instant admitting the truth of an in-
sane delusion, and at suitable times — not obtrusively, but
when occasion offers — urging such arguments against it as
would be convincing to persons of sound minds, the lunatic
comes at last to see the falsity of his ideas, and to laugh at
them himself. Little by little he loses faith in his perverted
reason, and, though he may take up another delusion, the
last is held with much less tenacity than the first.

Amusements are generally of service, and a proper sys-
tem of rewards and punishments is understood by all but the
most furious maniacs. Kindness and forbearance, supported
by firmness, will not altogether fail in their infiuence with
even the most confirmed and degraded lunatics.

SECTIO)^ II.
DISEASES OF THE SPII^AL COED.

CHAPTER I.

SPINAL CONGESTION.

Though congestion of the spinal cord, like that of the
brain, is of two kinds, active and passive, yet the symptoms
and general course of the two varieties are so generally alike,
that nothing would be gained by considering them sepa-
rately.

Symptoms. — The symptoms of spinal congestion are re-
ferable to the cord and to those parts of the body below the
seat of the lesion. The most prominent local phenomenon is
pain, which is rarely acute, but is described as a dull, aching
sensation similar to that experienced in the back after severe
and long-continued muscular exertion in a stooping attitude.
This pain is increased by tlie recumbent posture and by
standing, if the lower part of the cord be its seat ; but press-
ure, if steadily applied, does not augment it. A sudden
blow or a shock, such as that produced by making a false
step, aggravates it to a considerable extent.

A sensation of heat is occasionally experienced in the
cord, which is not unpleasant, and which is not affected by
pressure.

386

DISEASES OF THE SPINAL CORD.

"With the local symptoms there are others still more no-
table perceived in the parts of the body below the seat of the
disease. Thus, if, as is very generally the case, the lesion be
situated in the dorsal or lumbar region, there are disturb-
ances of sensibility and motility in the lower extremities.
The various sensations indicating anaesthesia are present, and
are usually first experienced in the skin covering the under
surface of the toes. Formication, " pins and needles," tin-
gling, and a feeling as if the toes are swollen, are noticed. It
is rarely the case that the anaesthesia is complete. Its ex-
tent and exact situation may be accurately determined by
the aesthesiometer.

Sometimes there is hyperaesthesia, and occasionally both
conditions coexist. The extent of either may be accurately
measured with the aesthesiometer. Shooting pains in the
limbs and along the course of the nerves coming from the
diseased part of the cord are now and then present, but
they are not a prominent feature in simple congestion.

A sensation of constriction is at times complained of, and
is referred to the body or one or both of the limbs. It is
compared to the feeling which would be produced by a tight
cord or encasement in an unyielding garment. It is rare in
uncomplicated spinal congestion. According to the situa-
tion of the lesion, there are pains either in the abdomen,
chest, or both, and there may be dyspnoea and palpitation
of the heart. In three cases under my care, the difficulty
of breathing and irregular cardiac action were prominent
features. Similar cases are cited by Ollivier' (d'Angers).
The temperature of the parts of the body below the lesion is
always reduced, from the fact that the vaso-motor nerves
are involved.

Erections of the penis are common, especially after the
patient has been in the recumbent position for some time.
The most striking phenomena of spinal congestion are

' Traits des Maladies de laMoelle fipiniere. Troisieme edition. Paris, 1837,
tome iii., pp. 1-137.

SPINAL CONGESTION.

387

those connected with the alterations of motility. Para-
plegia is always present to some extent, though it is rarely
complete. Thus the patient, though unable to walk, can
generally move the legs when sitting down or lying in bed.
Twitchings of the muscles are occasionally present, but not
often to a severe degree.

The loss in the power of motion, like the alterations in
sensibility, is only present in those parts of the body situ-
ated below the diseased parts of the cord. The bladder is
very generally affected, either in its own muscular tissue or
in its sphincter. In the first case, there is a difficulty of ex-
pelling the urine, owing to loss of expulsive power, and this
is aggravated by paralysis of the abdominal muscles, or there
is incontinence of urine from paralysis of the sphincter.
Both conditions may coexist, and then, when a sufficient
quantity of urine has accumulated in the bladder, it dribbles
away. In such a condition, the bladder is never entirely
empty, and the urine is passed alkaline and fetid.

The sphincter of the rectum is sometimes involved, pro-
ducing involuntary evacuation of the fjEces, but obstinate
constipation from paralysis of the abdominal muscles, and
consequent loss of expulsive power, are much more common.
Eeflex excitability is, according to my experience, invari-
ably lessened, and is sometimes entirely abolished.

The electro-muscular contractility of the paralyzed mus-
cles is always more or less diminished, though not to the
same extent as in some other affections of the cord. As a
general rule, the farther the muscle is from the centre the
less is its electro-muscular contractility.

The tendency of spinal congestion is to extend itself and
eventually to involve the whole cord. In the active form
of the disease, this process often takes place with great
rapidity, and the symptoms generally are more pronounced
and succeed each other with more promptness. The phe-
nomena of spinal congestion are always rendered more de-
cided by the patient's assuming the recumbent posture. He

388

DISEASES OF THE SPINAL CORD.

is hence more paralyzed in the morning before rising from
bed than in the evening before he retires. This is due to
the fact that the position in question, especially if he lies
on his back, allows the spinal blood-vessels to become more
readily distended. It is the same thing, as regards the cord,
that keeping the head in a dependent position would be as
regards the brain.

Bed-sores are not common. Radcliffe ' seems to assert
that they are never met with. Brown-Sequard " says an ul-
ceration upon the sacrum or nates is not rare in this affec-
tion. Ollivier ' does not mention them in his account of the
disease. Of sixty-two cases of spinal congestion which have
been under my care during the last six years, or in which I
have been consulted, bed-sores occurred in but two, and in
these there was reason to believe they were not the special
result of the lesion of the cord.

According as the antero-lateral or posterior columns are
mainly affected, the symptoms of spinal congestion differ.
Thus, in the former case, the phenomena are chiefly mani-
fested as regards motility, in the latter as regards sensibility.
Generally both sets of columns are involved. In spinal
anasmia, as we shall presently see, this is not the case.

Causes. — The most common cause of spinal congestion,
according to my experience, is exposure to intense cold.
This was the alleged cause in eighteen of the sixty-two cases
previously referred to as having come under my observation.
Fevers appear to be next in frequency, especially those of
malarious origin, nine cases being referred to this influence.

Venereal excesses were the apparent cause in five cases,
and maintaining the erect posture for a long time was the
obvious cause in three cases. This last influence was very
well marked in the case of an eminent lawyer of this city,
who became suddenly affected with spinal congestion after

' Reynolds's System of Medicine, vol. ii., p. 622.

* Lectures on the Diagnosis and Treatment of the Principal Forms of Paral-
ysis of the Lower Extremities, Philadelphia, 1861, p. 69. ^ Op. cit.

SPINAL CONGESTION.

389

making a speech of several hours' duration. The suppres-
sion of a customary discharge, such as the menstrual flow or
a haemorrhoidal bleeding, is likewise liable to induce con-
gestion of the cord. Three cases under my charge were
thus caused. Two were the result of blows, one of severe
muscular exertion, and in the remainder no cause could be
with any degree of certainty ascertained,

AmoTig the effects of working under compressed air,
spinal congestion must be included. Drs. Babington and
Cutlibert,' of Dublin, have called attention to this fact, and
Dr. Clark,' of St. Louis, has recently brought forward sev-
eral additional cases occurring in the workmen in the cais-
son used in building the bridge over the Mississippi River.

Passive spinal congestion may be caused by any obstruc-
tion to the return of blood by the veins, such as cirrhosis of
the liver, pregnancy, abdominal tumors of various kinds, dis-
eases of the lungs or right side of the heart, and the long-
continued maintenance of the dorsal decubitus.

Diagnosis. — Spinal congestion is liable to be confounded
with several other affections, and with some to the great in-
jury of the patient. Thus it may not be distinguished from
spinal anaemia, a condition likewise giving rise to para-
plegia, but of which the treatment is very different.

It may be diagnosticated from this affection by the facts
that in spinal aneemia there is pain in the cord, increased by
pressure on the spinous processes of the vertebrje, or, if there
is no spontaneous pain, such pressure causes it ; by the dis-
turbance induced in the cranial, thoracic, or abdominal
viscera, according to the part of the cord affected, being
much more prominent ; by the circumstance that women are
more generally its subjects ; that there is often a previous
affection generally of the urinary organs which has caused
the anaemia ; but, above all, by the fact that in spinal anaemia

' Paralysis caused by working under Compressed Air, Dublin Quarterly Jour-
nal of Medical Science.

* St. Louis Medical and Surgical Journal

390

DISEASES OF THE SPINAL CORD.

the symptoms are less strongly marked after the patient has
been lying down some time, whereas the reverse is the case
in congestion.

Spinal anaemia never produces any urinary difficulty,
although such trouble may cause spinal anaemia. In a case,
therefore, in which there was doubt as to the spinal cord
being in a state of congestion or anaemia, the order of se-
quence, as regards the paraplegia and bladder-difficulty,
would seem to render the diagnosis exact. In spinal anae-
mia the bladder is affected before the paraplegia appears ;
in spinal congestion the paraplegia comes on before the blad-
der is involved.

In spinal anaemia there is no formication, pricking,
tingling, or other sensation indicative of anaesthesia. Hy-
peraesthesia is, on the contrary, exceedingly common.

The further diagnostic marks will be considered when
we come to the subject of spinal anaemia.

Congestion is distinguished from inflammation of the
cord by the facts that in it the jerkingsof the limbs are slight,
that the paralysis is not so extreme, that the urine is never
alkaline, that the pain in the cord is less, and by the infre-
quency of the feeling of constriction at the upper limit of
the lesion.

From meningitis it is diagnosticated by the absence of
spasms in the muscles of the back, and by the fact that
movements of the paralyzed limbs do not cause pain.

Prognosis. — In simple uncomplicated spinal congestion
the prognosis is not unfavorable, if, in addition, the case be
put under suitable treatment at an early period. It must
be remembered, however, that there is a tendency to inter-
stitial changes, and that, if the vessels of the cord be left for
a long time in a state of turgidity, it may be impossible to
prevent structural alterations of greater severity. Yery few
of the cases that have come under my own immediate notice
were in the first stage of the affection, but yet twenty-three
were entirely cured, nineteen were greatly relieved, seven

SPINAL CONGESTION.

391

are still under treatment, six are known to have died, and
the rest were lost sight of, most of them not having been
under my immediate charge.

Morbid Anatomy. — The post-mortem appearances in cases
of congestion of the spinal cord are either in the cord prop-
er or its membranes. As regards the first, section shows
increased vascularity both of the gray and the white sub-
stance, especially if microscopical examination be made.
The capillaries will be found increased in size and more
numerous than in the normal condition.

The membranes of the cord contain very large and very
tortuous vessels, and in congestion they are rendered still
larger and more complex in their anastomoses. The press-
ure which they are capable of exerting upon the cord is not
inconsiderable.

It is almost invariably found that the cerebro-spinal
fluid is increased in quantity.

These evidences of congestion are sometimes extremely
limited in their extent, at others the whole length of the
cord is involved.

Pathology. — The symptoms which result from congestion
of the cord are of two distinct classes: increased ex-
citability from hypersemia, and interruption of the proper
functions of the cord from pressure. The former, in the
main, results from the increased amount of blood in the
gray matter and white substance ; the latter from the en-
larged meningeal vessels and the increased amount of cere-
bro-spinal fluid, which, in the form of serous efiusion, is the
result of their turgidity. As one or the other of these con-
ditions predominates, we have some symptoms more promi-
nent than others. Thus hyperagsthesia indicates rather hy-
persemia of the gray substance, anaesthesia pressure upon the
white substance. Twitchings, when present, are likewise
the result of over-excitation of the gray tissue ; while motor
paralysis is induced by pressure upon the antero-lateral col-
umns.

392

DISEASES OF THE SPINAL CORD.

Tlie modifications wliicli may be produced in the inten-
sity of the symptoms by the position of the body show the
effect of pressure very clearly. In the recumbent posture
on the back, tlie blood gravitates in large amount to the
spinal vessels, pressure on the cord is increased, and the
phenomena of anaesthesia and paralysis are more strongly
marked. Again, causes which increase the activity of the
circulation, such as alcoholic stimulants, and others which
directly augment the amount of blood in the cord, such as
strychnia and phosphorus, invariably increase the hyperaes-
thesia and induce muscular twitchings, even if they have
not previously been observed.

Treatment. — In cases of spinal congestion which come on
suddenly, and which are therefore acute in their character,
such as result from the sudden arrest of an habitual dis-
charge, blood may be drawn locally from the spinal region
by cups or leeches. The best place for the application of
the latter is the verge of the anus, and I have several times
witnessed very decidedly satisfactory results from their use
in this situation.

Purgatives are likewise beneficial, and preference should
be given to those which produce watery evacuations, as
thereby the overloaded vessels are relieved, and the absorp-
tion of the superabundant cerebro-spinal fluid facilitated.
Nothing can be better for this purpose than the sulphate of
magnesia given in doses of a drachm two or three times
a day.

In this form the ergot of rye may be given with advan-
tage from the very inception of the disorder. In the more
chronic form it is indispensable. It should be administered
in very much larger doses than are laid down in the text-
books on materia medica. I am in the habit of using it, in
this and analogous spinal diseases, in doses of a drachm of
the fluid extract three times a dav. The action of the ergot
is to lessen the diameter of the blood-vessels of the cord by
its constringing power over the organic muscular fibre en-

SPINAL CONGESTION.

393

tering into the composition of tlieir walls. Ten years ago *
I spoke as follows: "But I have recently ascertained by
actual experiment that ergot does exert the influence in
question. I prepared a weak aqueous infusion of this sub-
stance and placed it on the web of a frog's foot under the
microscope. In a few moments contraction of the capilla-
ries ensued, and they became so small as not to allow of the
passage of the blood-corpuscles. This experiment I have
repeated several times, and am perfectly satisfied that the
result is as I have stated. More, I have frequently injected
small quantities of the infusion into the stomach of frogs,
and contraction of the capillaries of the web always fol-
lowed."

This was certainly the first demonstration of this very
important action of ergot.

Since that time I have given it in a large number of
cases of diseases of the spinal cord, congestion among them,
in which it was necessary to diminish the amount of blood
in the spinal vessels, and I am entirely satisfied that such is
its efiect ; but I never obtained its full influence till, in ac-
cordance with the suggestion of my friend Dr. A. Jacobi,
of this city, I adopted the practice of giving it in what may
be called very large doses. Among the cases which first
came under my care, since my residence in New York, was
that of Mr. W., of Tennessee, who had become afiected with
congestion of the cord, from exposure to cold and dampness.
When I first saw him he was unable to walk without the
assistance of crutches, and a man on each side of hiiri hold-
ing his shoulder. He had paralysis of the bladder, which
had come on after the paraplegia, and a constant, dull,
aching pain in the loins. There were also occasional start-
ings of the legs, especially after he had gone to bed. All
his symptoms were worse in the morning. I at first gave
him ten drops of the fluid extract of ergot three times a day,

' A Clinical Lecture on Chronic Myelitis, delivered in the Baltimore Infir-
mary, March 16, 186L American Medical Times, June 15, 1861, p. 379.

394

DISEASES OF THE SPINAL CORD.

but, continuing this for two weeks without efiect, I at once
increased the doses to a teaspoonful. In less than a week
the effects were manifest. Sensibility began to return in
the extremities, the strength increased, the bladder began
to contract on its contents, the lumbar pains ceased, and by
the end of a month he had entirely recovered. A few weeks
afterward he had a relapse, but the ergot, taken as before
for ten days, again restored him, and he has since remained
perfectly well.

I cite this case because it is one in which nothing else
but the ergot was given, and as one in which its influence
was twice distinctly manifested.

Belladonna is also a valuable remedy in spinal conges-
tion, especially when there is paralysis of the sphincter, or
when the pain in the back is severe. The tincture, in
doses of fifteen drops three times a day, may be employed,
and a belladonna plaster may be applied to the painful re-
gion of the spine.

The hot douche — the water being of the temperature of
98° Fahr. — to the spinal column is an excellent means of
determining the blood from the deep to the superficial ves-
sels. The water should be allowed to fall from the height
of about two feet upon the naked back over the diseased
part of the cord every day for about five minutes. Dry
cups are also valuable adjuncts.

Electricity is always useful. The constant current should
be applied to the spine over the affected part of the cord,
the positive pole being held at the upper limit of the lesion,
and the negative rubbed up and down all the part below.
The duration of the application should not exceed ten min-
utes. By this means the calibre of the spinal vessels is
probably lessened. At any rate the downward current cer-
tainly is beneficial, while the upward increases the intensity
of the symptoms.

The induced current should be used to the paralyzed
muscles, so as to excite them to contract. In this way their

SPINAL CONGESTION.

395

nutrition is promoted, and any tendency to atrophy from
disuse obviated.

The primary current should not be employed more fre-
quently than every alternate day. The induced may be
used every day for half an hour or longer, short of causing
fatigue.

I will only add that strychnia and phosphorus should
never be administered in congestion of the cord, as their ac-
tion is the very reverse of that desired, and irreparable dam-
age may be done by their use.

CHAPTER II.

SPINAL ANEMIA.— ANEMIA OF THE POSTERIOR COLUMNS.—
ANEMIA OF THE ANTERO-LATERAL COLUMNS.

A DEFICIENT quantitv of blood in the spinal cord, or a
depravation in the quality of the blood circulating through
its tissue, gives rise to two cognate, but, so far as their phe-
nomena go, different affections. In one of these, which has
hitherto been known as spinal irritation, the morbid action
is in a great measure confined to the posterior columns of
the cord ; in the other, which embraces several differently-
named disorders, characterized by paralysis, such as reflex
paralysis, inhibitory paralysis, spinal paresis, paralysis from
peripheral irritation, etc., the antero-lateral columns are
mainly affected.

In thus specifically locating the lesions in these affec-
tions, I am aware of the fact that post-mortem examinations
are wanting to support them. Nevertheless, the symptoms
characteristic of each are so distinctly marked, and are in
such intimate physiological relation with the regions of the
cord specified, tliat I do not think I am at all exceeding the
limits of probability.

Retaining the name of spinal irritation, as one well
known to the profession, it will nevertheless be understood
that, in my opinion, the proper designation of the disease
would be anaemia of the posterior columns of the spinal cord.
I have arrived at this view after a very careful consideration
and analysis of the symptoms observed in a large number
of cases.

SPINAL ANJEMIA, ETC.

397

The same remarks are applicable, mutatis mutandis, to
reflex paraplegia, a symptom which I am very sure results
from ansemia of the antero-lateral columns of the cord.

ANEMIA OF THE POSTERIOR COLUMNS OF THE SPINAL CORD. —
SPINAL IRRITATION.

History. — It has been questioned by several distinguished
authors whether such an affection as spinal irritation really
exists as a distinct disease. Thus Yalleix ' ascribes the most
important of its manifestations to hysteria, and regards the
spinal tenderness present as being due to simple intercostal
nem-algia ; Inman considers the pain produced by pressure
over the spinous processes of the vertebrae as existing in the
muscular attachments, and as indicative of what he calls
myalgia. Mr. Skey ' evidently looks upon all cases of spinal
irritation as hysterical in their character, and Niemeyer*
speaks incredulously on the subject, without giving any very
decided opinion. It would be easy to bring forward other
authorities who have expressed similar views, and I may
have to allude to some of them more fully hereafter. In
the recently-published nomenclature of the Eoyal College
of Physicians,* the affection has no place unless it be in-
cluded under the head of hysteria.

The first author who distinctly grouped together the
symptoms of spinal irritation was J. Frank," who, under the
name of rachialgia, described the disorder with considerable
accuracy, and laid the principal stress upon the local pain.

* Traite des nevralgies, ou affections douloureuses des nerfs. Paris, 1841,
p. 345.

* On Myalgia : its Nature, Causes, and Treatment, etc. Second edition,
London, 1860, p. 225, et seq.

^ Hysteria, etc.. New York, 1867, p. 72, et seq.

* A Te.xt-Book of Practical Medicine. American edition. New York, 1869,
vol. ii., p. 258.

^ The Nomenclature of Diseases drawn up by a Joint Committee appointed
by the Royal College of Physicians of London. London, 1869.

* De Rachialgitide, in Prax. med. univ., P. IL, t. i., p. 37.

398

DISEASES OF THE SPINAL CORD.

He was followed by Stiebel/ who, however, contributed lit-
tle to our knowledge of the subject.

Mr. J. R. Player" was among the first English physi-
cians, if not the very first, to call attention to the fact that
eccentric derangement of function may be the result of irri-
tation of the spinal cord. Thus he says : " Most medical
practitioners who have attended to the subject of spinal dis-
ease must have observed that its symptoms frequently re-
semble various and dissimilar maladies, and that commonly
the function of every organ is impaired whose nerves origi-
nate near the seat of disorder. The occurrence of pain in
distant parts forcibly attracted my attention, and induced
frequent examination of the spinal column ; and, after some
years' attention, I considered myself enabled to state that,
in a great number of diseases, morbid symptoms may be dis-
covered about the origins of the nerves which proceed to the
affected parts, or of those spinal branches which unite them ;
and that, if the spine be examined, more or less pain will
commonly be felt by the patient on the application of press-
ure about or between those vertebrae from which such nerves
emerge."

The term " spinal irritation " appears to have been first
used by Dr. 0. Brown,' of Glasgow, who, in a very excellent
paper, gives a picture of the disorder which cannot i'ail to be
recognized as truthful and exact by those who have wit-
nessed several cases of the affection. He insists upon not
confounding the complaint with those organic diseases of
the vertebrae and spinal cord which some of its symptoms
cause it to resemble, points out the variation of the phe-
nomena according to the seat of the spinal tenderness, and
inculcates the employment of rest and counter-irritation as
the most effectual remedies. His ideas of the pathology of

' Ober Neuralgica Rachitica, Rust's Magazine, t. i., c. xvi., p. 549.
^ Quarterly Journal of Science, vol. xii., p. 428. Quoted by Teale.
3 On Irritation of the Spinal Nerves. Glasgow Medical Journal, No. II.,
May, 1828.

SPINAL ANEMIA, ETC.

399

the disease are : " That the immediate cause of the pain of
the back and breast is spasm of one or other of the muscles
arranged along the spine altering the position of the ver-
tebrse, or otherwise compressing them as they issue from the
spinal marrow.

" That this spasm in many instances is strictly a local
disease, produced by fatigue, wrong posture, or other causes,
and quite unconnected with the state of the brain, spinal
marrow, or nervous system in general.

"But that, in other formidable instances, this partial,
spasmodic, or wrong action of the muscles, is owing to a
faulty state, perhaps an enlargement, of the vessels of the
brain or spinal marrow. This state of the brain, as in many
other diseases, gives rise to spasm or even to convulsion of
certain muscles ; which partial symptom, from its severity,
attracts the chief attention. This local affection is confined
to those portions of the spine where there is the greatest
motion, and where, of course, the muscles having the great-
est activity are most liable to deranged action or spasm. I
imagine tliat this view of the subject is illustrated and per-
haps confirmed by various symptoms which were observed
in the difiierent cases, and which without it were very in-
comprehensible. The partial palsy, the affection of the
sight, the giddiness of the head (for I find that this was a
prominent symptom in several cases, especially in that of A.
S.), all give some confirmation to the notion that the brain
is affected in these severe cases."

Dr. Darwall,' of Birmingham, describes several features
of the affection with accuracy, such as those simulating car-
diac and gastric diseases. He is inclined to believe that the
morbid condition of the spinal cord depends mainly upon
irregularity of the circulation, generally congestion.

But no essay upon the subject of spinal irritation, which
had yet appeared, w^as equal in thoroughness to that of Mr.

1 On some Forms of Cerebral and Spinal Irritation. Midland Medical Re-
porter, May, 1829.

400

DISEASES OF THE SPINAL CORD.

Teale/ and it is to him that the views now generally held
relative to the connection between various eccentric phe-
nomena, such as pain, spasm, and visceral disturbance, and
a peculiar condition of the spinal cord, are to be attributed.
He, however, committed the great error of regarding the
affection as being due to inflammation, and, in what for
those days was logical accordance with this theory, he com-
bated it with strong antiphlogistic measures. His book
may be studied with advantage, as presenting an admirable
account of the many diverse phases which spinal irritatioH
may assume.

Mr. Tate," in his work on hysteria, attributes many of
the protean manifestations of this disorder to spinal irrita-
tion, limited, however, to the dorsal region. He fails to
recognize it as an independent disease. His treatment con-
sists in the application of tartar-emetic ointment along the
whole length of the dorsal vertebrae, and strong purgation.
He discountenances the use of leeches and blisters.

Mr. W. R. Whatton ' insists chiefly upon the liability
to mistake spinal irritation for disease of the vertebrae. He
gives a very excellent account of the symptoms. The treat-
ment he recommends consists in the abstraction of blood, by
leeches or cups, from the parts where the tenderness is felt,
repeated every three or four days, and the application of
small blisters on each side of the painful spots. Any debil-
ity ensuing in consequence of this treatment is to be reme-
died by the preparations of iron and quinine.

In a clinical lecture delivered in Dublin, Dr. Corrigan *
relates the particulars of several cases of spinal irritation,
successfully treated by local antiphlogistic measures, and

' A Treatise on Neuralgic Diseases dependent upon Irritation of the Spinal
Marrow and Ganglia of the Sympathetic Nerve. London, 1829.
^ Treatise on Hysteria. London, 1830.

^ On Spinal and Spino-Ganglial Irritation. North of England Medical and
Surgical Journal, No. IIL, 1831.

* Medico-Chirurgical Review, July, 1831, p. 182.

SPINAL ANiEMIA, ETC.

401

the internal use of iron. He does not, however, add any
thing of importance to our previous knowledge of the sub-
ject.

Dr. Isaac Parish,' of Philadelphia, appears to have been
the first American author who called attention to the affec-
tion in question. He relates the details of several cases,
recommends the use of counter-irritants, especially tartar-
emetic ointment, and concludes :

" First, that tenderness on pressure in some portion of
the spinal cord is an attendant on many chronic neuralgic
afi'ections, and that, by relieving it in the manner proposed,
these complaints are either entirely eradicated or tempora-
rily suspended.

" And, secondly, that the precise indications which this
circumstance affords are not sufficiently understood at the
present time to justify the establishment of any definite
pathological principles applicable to the whole class of neu-
roses."

Dr. W. Griffin and his brother, Mr. D. Griffin,' of Lim-
erick, were the next to write upon the subject. The joint
work of these gentlemen is based upon one hundred and
forty-eight cases, all of which are thoroughly analyzed, and
from which very definite deductions of pathology and treat-
ment are drawn. The essay is not excelled in importance
by any previous contribution, and constitutes a really valu-
able study. The conclusions which they draw are so in-
structive that I do not hesitate (though by no means indors-
ing them all) to transfer them without abbreviation :

" 1. That tenderness at one or more points of the spine
is an attendant on almost all hysterical complaints, on nu-
merous cases of functional disorder when the hysteric dispo-

' Remarks on Spinal Irritation as connected with Nervous Diseases : with
Cases. American Journal of the Medical Sciences, vol. x., 1832, p. 223.

° Observations on the Functional Affections of the Spinal Cord and Gangli-
onic Nerves, in which their Identity with Sympathetic, Nervous, and Simulated
Diseases is illustrated. London, 1834.
26

402

DISEASES OF THE SPINAL CORD.

sition is not so obvious, and in many nervous or neuralgic
affections.

" 2. That many of the symptoms of these affections evi-
dently depend upon a peculiar state of certain nerves, prob-
ably at their origin, may be reproduced at any moment by
pressure, and are often relieved by remedies applied there.

" 3. That, in all cases of tenderness of the cer^dcal and
upper dorsal spine, there was nausea, or vomiting, or pain
of stomach, or affections of the upper extremities; but no
pain of the abdomen, dysury, ischury, hysteralgia, or affec-
tions of the lower extremities.

" 4. That, in all cases of dorsal tenderness, pains affect-
ing the abdomen, bladder, uterus, testes, or lower extremi-
ties, were usual symptoms ; while nausea, vomiting, or
affections of the upper.extremities, were never complained of.

" 5. That nausea and vomiting appeared to have more
relation to tenderness of the cervical spine, pain of stomach
to tenderness of dorsal ; but that, when there was soreness
of both, nausea or vomiting was still more frequent, and
pain of the stomach scarcely ever absent.

" 6. That, when several points or a great extent of the
spinal column is painful and tender on pressure, local reme-
dies are generally less effectual, and there is a strong dispo-
sition to transference of the disordered action from one organ
to another ; the pain or tenderness, in all such cases of trans-
ference, shifting its place to a corresponding part of the
spinal column, leaving the original point free, or with a
very diminished degree of tenderness.

" 7. That spinal tenderness is seldom or never met with
in cases of pure inflammation, except when these accident-
ally occur in persons previously suffering from irritation of
the cord ; and that, when appearances of inflammation pre-
sent themselves in any org^n accompanied by a correspond-
ing spinal teiaderness, they cannot commonly be removed
by the remedies applicable to inflammatory cases, and are
often rendered worse by them.

SPINAL ANEMIA, ETC.

403

" 8. That there does not appear to be a complaint to
which the human frame is liable, whether inflammatory or
otherwise, which may not be occasionally irritated in dis-
turbed states of the cord ; and hence that this disturbed
state is one vast source of those complaints called hysterical
or nervous.

" 9. That those functional disorders connected with spi-
nal tenderness are very often attended by some disturbance
of the functions of the uterus, but that they are by no
means always so, since they occur in those who are regular
in, this respect : in girls long before the menstrual period of
life, in w^omen after it has passed, and, lastly, in men of
nervous susceptible habits, and in boys.

" 10. That in fact they are not necessarily dependent
upon any one organ ; since they are found indifferently co-
existing with disturbance of the digestive organs solely, or
the uterus solely, or of the circulatory or respiratory system.

"11. That from the cases detailed we have reason to
suppose spinal tenderness may arise from uterine disorder,
from dyspepsia, from worms in the alimentary passages,
from affections of the liver, from mental emotions, from the
poison of typhus, from marsh miasmata, from erysipelatous,
rheumatic, and eruptive fevers, and from the irritation aris-
ing from local injury.

" 12. That it is almost invariably found, in connection
with gastric or abdominal tenderness, in fever ; and this
tenderness is, probably, like the soreness of scalp, pains in
the limbs, etc., dependent on the morbid state of the cord.

" 13. That, whether in fever or in other complaints, it is
met with in the situation of the eighth or ninth dorsal ver-
tebra much more frequently than at any other part of the
spine.

"14. That affections attended by spinal tenderness are
seldom fatal ; that, even, in those cases of intense irritation
of the cord under which patients suffer extremity of pain
for years, the event is generally favorable.

404

DISEASES OF THE SPINAL CORD.

"15. That they frequently, as well as hysteria, occur
with all the appearances of a primary affection of the ner-
vous system.

" 16, That affections are occasionally met with present-
ing all the marks of the hysteric character, and perfectly
resembling cases described as those of spinal irritation, but
unattended by spinal tenderness or any other direct indica-
tion of a morbid state of the cord."

The treatment recommended consists in the removal of
the cause if this still continues in action, purgatives, the
application of blisters and leeches to the skin, the internal
administration of hyoscyamus and belladonna, to lessen the
nervous irritability, alum in cases of gastric derangement,
and change of air and scene.

In a subsequent work, the Messrs, Griffin * again discuss
the subject, but bring forward no additional facts.

Dr. John Marshall ' is confident that many visceral affec-
tions, such as heart-diseases, asthma, phthisis, dyspepsia,
diabetes, chorea, and even phlegmasia dolens, are frequently
really produced or simulated by spinal irritation. Some of
his cases of supposed functional disorder of the spinal cord
are, however, obviously organic, consisting of congestion,
inflammation, or softening of the organ.

In his classical work, Ollivier ' devotes considerable space
to what he calls " an, Affection described under the name of
Spinal Irritation^ He considers the pathological condi-
tion to be one of congestion of the meninges of the cord,
and bases this opinion in great part on the success which,
according to him, ensues on the use of leeches, blisters, and

' Medical and Physiological Problems : being chiefly Researches for correct
Principles of Treatment in Disputed Points of Medical Practice. London,
1845.

* Practical Observations on Diseases of the Heart, Lungs, Stomach, Liver,
etc., occasioned by Spinal Irritation, and on the Nervous System in General as
a Source of Organic Disease. London, 1835.

* Traite des Maladies de la Moelle Epiniere. Troisieme Edition. Paris,
1837, t. seconde, p. 209.

SPINAL ANEMIA, ETC.

405

counter-irritant ointments. In addition, lie favors the ad-
ministration of opium, digitalis, hyoscyamus, belladonna,
and subcarbonate of iron.

Tiirck ' regards the phenomena of spinal irritation as
being due, first, to disorder of other organs, whereby a mor-
bid impression is propagated along the incident excitor
nerves to the spinal cord, or, second, to derangement of the
capillary circulation of the cord. That is, the disease may
be either of eccentric or centric origin. He does not ad-
vance our knowledge beyond the point reached by previous
authors.

Coming again to our own country, we find that in 1844
a very valuable paper was published by Prof. Austin Flint,^
based upon fifty-eight cases of functional disorder connected
with an abnormal condition of the spinal cord. In this
memoir, without going into any discussion relative to the
pathology of the afiection, Dr. Flint considers the disorder
as giving rise to tenderness over the vertebral column, caus-
ing alterations of sensibility, as afi*ecting the muscular sys-
tem, as producing abnormal mental manifestations, as affect-
ing the digestive organs, the genito-urinary organs, the heart
and circulation, and as causing paroxysms of sinking. He
then considers the physical habits of the patients, the results
of medical treatment, the probable remote causes, and then,
at some length, the remedial measures which he has found
most successful. Under this head, Dr. Flint advises the use
of counter-irritants to tlie spine, especially capping, and
generally without scarification. Issues he found inapplica-
ble, death ensuing in the one case in which he used them.
There is no doubt, however, that in this instance he had an
organic disease to deal with, and that the issues had nothing
to do with the fatal result. Tonics, especially iron, he found
to be of great advantage.

' Abhandlung iiber spinal Irritation, u. s. w. Wien., 1843.
^ Observations on the Pathological Relations of the Medulla Spinalis. Amer-
ican Journal of the Medical Sciences, April, 1844, p. 269.

406

DISEASES OF THE SPINAL CORD.

In a very full analysis of the medical reports of the
Stockholm Hospital, by Dr. Magnus Huss/ the subject of
spinal irritation receives due consideration. Dr. Huss class-
es the symptoms of the disorder as follows : 1. Pain of
various parts of the vertebral column, existing either idio-
pathically or developed by pressure. 2. Cramps, either of
a clonic or tonic nature, in those parts subjected to the in-
fluence of the spinal cord. 3. Loss of power in the same
portions of the body, ranging from simple stiffness and
weakness to complete paralysis. 4. Altered sensibility,
either by excess or by great diminution of sensation.

It will be observed that in this enumeration the author
confines his specification of morbid phenomena to those
which relate to sensation and the power of motion.

The treatment is fully and philosophically considered.
Of external remedies he prefers counter-irritants, using the
milder forms first, and then the severer, such as the moxa
and the actual cautery, should the first fail. Venesection,
either general or local, should be cautiously employed, and
is not generally indicated. He is the first, so far as my re-
searches extend, to mention electricity, a means which he
thinks may be employed with advantage in chronic and de-
bilitated cases. Potash-baths are also recommended.

Of internal remedies he specifies iron, opium, strychnia,
phosphorus, and valerian, as being preeminently useful.

Axenfeld' devotes a considerable portion of his treatise
to spinal irritation. He regards it as being produced either
by a trouble of innervation or congestion. In the treatment,
leeches occupy the first place, and in light cases blisters,
sinapisms, dry cups, and stimulating frictions, are useful.
Internally he recommends nothing but quinine and iron.

Dr. Radcliffe ' w' rites very sensibly on the subject of
spinal irritation, and gives a typical case which is quite in-

' British and Foreign Medical Review, October, 1846, p. 463.
" Des Nevroses, Paris, 1863, p. 284.

3 Reynolds's System of Medicine, London, 1868, vol. ii., p. 640.

SPINAL ANEMIA, ETC.

407

Btructive. He incidentally gives it as liis opinion, that the
pathologi-cal condition is one of anaemia, and he consequent-
ly discourages the use of leeches, relying mainly on blisters
and tonics.

I have thus cited the principal authorities upon spinal
irritation, without, however, by any means, exhausting tne
bibliography of the subject. Notwithstanding the eminence
of many of those who have contended for the existence of a
definite affection of the spinal cord, characterized by tender-
ness on pressure over one or more of the vertebrae, and cer-
tain eccentric disorders involving sensibility, the power of
motion, and functional derangement of many of the viscera,
it must be confessed that the great mass of the medical pro-
fession has regarded the whole theory with suspicion, if not
with absolute distrust. The principal reason for this is un-
doubtedly to be found in the fact that, like many other new
theories, that of spinal irritation has been applied to explain
conditions which it could not logically be made to cover.
Thus many cases of disease or disorder of the heart, due to
organic difficulties of that organ, or excited by disease of
other viscera through the sympathetic system, have been at-
tributed to spinal irritation. The same is true also of the
uterus, stomach, liver, and other organs, and even of the
spinal cord itself, which often, when the seat of organic dis-
eases, such as congestion, meningitis, inflammation, tumors,
etc., has been regarded as simply in a state of irritation. It
is very certain, also, that numberless cases of hysteria have
been attributed to irritation of the spinal cord. In the fol-
lowing remarks I will endeavor to be as explicit as possible,
and not to claim too much for a pathological condition
which I am very sure exists, and which I therefore think is
entitled to recognition. If I contribute any additional in-
formation, it will be mainly due to the fact that our means
of examination are much more perfect and extensive, and
our knowledge of physiology, pathology, and therapeutics,

408

DISEASES OF THE SPINAL CORD.

more thorough than when most of the authors I have quoted
wrote upon the subject. My observations are based upon a
careful study of one hundred and twenty-seven cases which
have occurred in my private practice during the last six
years, and of which I have full notes, and twenty-nine cases
of which I have less complete data — in all, one hundred and
fifty-six cases.

Symptoms. — Centric Symptoms. — 1. Tenderness at some
one or more Points over the Spinal Column^ increased ly
Pressure. — This is the essential symptom of spinal irrita-
tion, though varying in intensity from the slight degree of
pain experienced upon strong pressure to the acute hyper-
sesthesia, which does not allow of even the contact of the
clothing without the production of great suffering. It is
generally complained of by the patient, though occasionally
it has to be sought for by the physician. The brothers Grif-
fin found this symptom present in all but five out of one
hundred and forty-eight cases, and it is very probable that
these five were not cases of spinal irritation, a sui)position
which the authors themselves evidently entertain. Certain-
ly the details of the cases do not support the view which
would ascribe their phenomena to any affection of the spinal
cord. Most of the other authors I have cited refer to this
tenderness as a prominent feature. Parish thinks it alone
is to be relied upon as indicating irritation ; Mr. Whatton
declares that it is never wanting ; Axenfeld regards it as the
dominant and characteristic symptom ; and Radcliffe, while
admitting that it is not equally well marked in every case,
states the rule to be that spinal tenderness and spinal irri-
tation go together.

On the other liand, Flint does not regard tenderness as
an invariable and essential element of the affection under
consideration. He found it absent or indistinct in five of his
fifty-eight cases, while the other attendant circumstances
furnished unequivocal evidence that the diagnosis was cor-
rect.

SPINAL ANEMIA, ETC.

409

My own opinion would lead me to consider no case as
one of spinal irritation in which tenderness on pressure over
the vertebrae was absent. In the one hundred and twelve
cases noted by me, this symptom was present in all. There
are diseases of the spinal cord, which produce derangements
of other organs of the body, and which are not characterized
by vertebral tenderness, but these are far more serious af-
fections than spinal irritation, and of altogether different
pathology.

The seat of the tenderness is generally in the dorsal re-
gion of the spine. The Griffins found cervical tenderness
in twenty-three cases, cervical and dorsal tenderness in
forty-six, dorsal alone in twenty-three, dorsal and lumbar
in fifteen, lumbar in thirteen, the whole spine tender in
twenty-three, and no tenderness in five. Of one hundred
and forty-eight cases, therefore, one hundred and seven
exhibited tenderness in the dorsal region.

Dr. Flint found cervical and dorsal tenderness in three
cases, lumbar and dorsal in ten, and dorsal alone in twenty-
one cases.

Of my own cases, twenty-five had cervical tenderness
only, thirty-seven cervical and dorsal, forty-five dorsal only,
nineteen dorsal and lumbar, fifteen lumbar only, and in fif-
teen the whole spine was tender. One hundred and sixteen
cases, therefore, of one hundred and fifty-six were character-
ized by dorsal tenderness, and in forty-five it was limited to
this region.

The degree and character of the tenderness are subject
to great variation. In some cases strong pressure is required
to develop it, while in others the least touch is insupport-
able. Sometimes there are shooting pains, which radiate
from the tender spot, while at others the liypersesthesia is
quite circumscribed. In a gentleman now under my care
with well-marked spinal irritation, and who has a tender
spot over the third lumbar vertebra, pressure not only causes
intense suffering at that point, but develops pain along the

410

DISEASES OF THE SPINAL CORD.

whole course of the crural nerves and their branches as far
as their terminations on the inner sides of the feet. An-
other, a lady, who has spinal tenderness over the eighth cer-
vical and first dorsal vertebrae, experiences, from pressure,
intense pain along the course of the first intercostal, the in-
ternal anterior thoracic, and all the nerves of the left upper
extremity. Why in these and other cases particular nerves
Bhould be afiected, is a question which will be more fully
considered hereafter.

The pain developed by pressure is not always of the same
character. Sometimes it is dull and aching, and at others
sharp and lancinating. I have not noticed that any very
definite relation exists between the character of the pain and
the severity of the other symptoms, though, as regards the
degree of pain of each kind, there is a marked connection.
By this I mean that a dull, aching sensation may indicate
as profound a pathological condition, and be accompanied
by as intense eccentric phenomena, as a sharp and lanci-
nating pain, though a severe aching pain and a severe lan-
cinating pain always indicate more serious disorder than
when these sensations are not so emphatic.

The character of the pain varies in accordance with the
tissue in which it is felt. The dull aching sensation is only
developed by strong pressure, and is seated in the muscular,
tendinous, or cartilaginous structures about the vertebras.
The sharp, piercing twinges excited by slight pressure arise
from the skin, and subcutaneous cellular tissue. With
these species of sensations, the aesthesiometer always shows
increased sensibility of the skin over and in the vicinity of
the painful centres.

To ascertain whether or not the tissues outside of the
spinal canal are in a state of hyperaesthesia, the pressure
should be applied with gradually-increasing force, by means
of the thumbs applied to the spinous processes and the in-
tervertebral spaces, as recommended by Flint. The exami-
nation should be thorough, and extend throughout the

SPINAL ANEMIA, ETC.

411

whole extent of the vertebral column. The fact that the
patient denies the existence of tenderness should have no
weight with the physician. Only a few days ago a young
lady consulted me for severe infra-mammary pain, headache,
and nausea. I at once suspected spinal irritation, but she
declared, in answer to my inquiries, that there was no sign
of tenderness anywhere over the spinal column. I insisted,
however, on a manual examination, and to her great sur-
prise found three spots that were exceedingly painful to
slight pressure. This young lady had been treated for
dyspepsia for several years, without deriving any benefit
from the measures used, but was cured by the treatment
which I shall presently fully consider. Occasionally it
happens that the tenderness is not perceived for some time
after the pressure is made. In a recent case I found the
interval to be over a minute, and then acute pain, following
ing the course of the nerves, was experienced. I am not
prepared to offer an explanation of this phenomenon.

2. Pain in the Spinal Cord. — The tenderness just no-
ticed is seated primarily externally to the vertebral canal,
and is developed by pressure. That which is now to be
considered is located in the spinal cord, and is, therefore,
capable of being produced by pressure upon non-tender
spots. It is a very common symptom, having been present
in one hundred and one of my cases. Generally it is con-
founded with spinal tenderness, from which, however, it is
quite distinct. It is aggravated by motion of the spinal
column, by action of the muscles which have their attach-
ments to the spinous and transverse processes, by percussion,
and sometimes by the erect posture. In the case of a gen-
tleman of this city, it was so great when he stood up that
he was forced to keep the recumbent position nearly the
whole time. When I first saw him he was wearing an
apparatus designed to keep the weight of the head from the
vertebral column, and to prevent the vertebrae pressing upon
each other, under the idea that he had disease of the inter-

412

DISEASES OF THE SPINAL CORD.

vertebral substance. I removed the instrument, and, treat-
ing him for spinal irritation, he recovered his health in a
few weeks.

Pain in the spinal cord, in the disorder under consider-
ation, is usually seated near the point of external tender-
ness, though it is often at a distance, and sometimes is felt
throughout the whole extent of the cord. The eccentric
phenomena bear a distinct anatomical and physiological re-
lation to it, aS do those which are connected with spinal
tenderness. There is likewise a similar connection existing
between the pain in the cord and the vertebral tenderness.

To ascertain the existence of spinal pain, when it is not
spontaneously felt or superinduced by muscular exertion,
percussion should be practised. The ends of the fingers
will answer for this purpose, though I prefer a little vul-
canized india-rubber hammer, and a plessi meter, such as are
sometimes used for percussing the chest. Even over spots
which exhibit much tenderness, the deep-seated pain in the
cord itself can clearly be distinguished.

EccENTKic Symptoms. — By far the most important and
noticeable symptoms of spinal irritation are to be found in
distant parts of the body. These vary in their character
and seat, according to the part of the spinal cord afiected.
Following the example of the Griffins, I shall consider these
symptoms as they depend upon irritation of the several re-
gions of the cord with which they are connected.

a. The Cervical Region. — Of the cases upon which this
paper is based, in twenty-five the irritation existed in the
cervical region only, of the spinal cord ; in thirty-seven, the
cervical tenderness was conjoined with dorsal tenderness,
and in fifteen with tenderness of the whole spine. Taking
the uncomplicated cases as presenting the clearest features,
the following would appear to be the more prominent symp-
toms of cervical spinal irritation.

Vertigo was an accompaniment in eleven cases, and
headache in fifteen ; noises in the ears in eight, and disturb-

SPINAL ANEMIA, ETC.

413

ances of vision in four. Fulness and a sense of constric-
tion across the forehead were complained of in several cases,
as was also tenderness of the scalp. In addition, the mind
was more or less aifected in every case, and in seven the
aberration was of such a character as almost to amount to
insanity. In one of these, a married lady, aged thirty,
there were several paroxysms of maniacal excitement
every day ; and in another, that of a young lady aged
twenty-three, so furious were the exacerbations that, for
fear she would injure herself or others, she had to be re-
strained by two strong nurses, who held her while the tits
lasted. The predominant type, however, was melancholia.

Sleep was deranged in every case, generally in the form
of insomnia, though in three cases the tendency to somno-
lence was excessive. In every case the dreams were of an
unpleasant character ; in two there was nightmare, and in
one somnambulism.

Neuralgic jpains were present in seventeen of the twenty-
five cases. If the upper part of the cervical region was the
seat of the irritation, these pains were experienced in the
scalp and face ; if the lower, they were seated in the neck,
the shoulders, upper part of the chest, and the upper extremi-
ties. Sometimes the pain was of a dull, burning character,
and was then generally seated in the muscles of the nucha.
Muscular effort always increased the suffering. In accord-
ance with Teale's experience, it several times occurred that
the neuralgia was intermittent, the paroxysms coming on
about sundown and lasting through the night. In none of
these cases was there anaesthesia.

Motility was interfered with in eighteen cases. Some-
times there were fibrillary twitchings ; in five cases there
were clonic sjpasms of the muscles of the face and neck ; in
three, general chorea ; in two, contractions of the flexors of
the arm on one side, so that the elbow was rigidly bent ; in
two, the contractions were in the flexors of the hands, and
in four, of the fingers. In one case there was complete loss

414

DISEASES OF THE SPINAL CORD.

of jpower over the hand ; in four, ajphonia / and in one,
ahnost constant hiccough while the patient was awake.

Nausea was present more or less in fifteen cases, and, in
one, part of every thing taken into the stomach was almost
immediately rejected. Pain in the stomach was not met
with in any case.

5. The Dorsal Region. — I found the dorsal region of the
spine tender in one hundred and sixteen cases. In thirty-
seven of these it was conjoined with cervical, in nineteen
with lumbar tenderness, and in fifteen it was afiected with
the whole spine, leaving forty-five uncomplicated cases.

The most prominent symptoms in these cases were con-
nected with the viscera, the stomach being the organ com-
monly involved. Thus, gastralgia was present in every
case, nausea and vomiting in nine cases, pyrosis in three,
gastric flatulence in forty, and acidity, as evidenced by
heartburn, in twenty-six.

Next in order came the heart. There were palpitations
in twenty- six cases, fits of oppression, during which the
heart beat with irregularity as regarded force and rhythm,
in ten cases, and attachs of syncope in five.

There was difficulty of hreathing in fifteen cases, and
cough in fifteen.

Intercostal neuralgia existed in ten, and infrormamr
mary pain in thirty-one cases.

There were no muscular spasms, contractions, or paraly-
sis.

In the thirty-seven cases in which the dorsal tenderness
was conjoined with cervical tenderness, the symptoms char-
acteristic of each region were more or less intermingled.
In two cases there was epilepsy, and in three chorea paror
lytica.

c. The Lumha/r Region. — This portion of the spine ex-
hibited tenderness in forty-nine cases. In nineteen of these
it was accompanied by dorsal tenderness, in fifteen the
whole spine was affected, and in fifteen the tenderness was

SPINAL ANEMIA, ETC,

415

confined to the lumbar region alone. Of these latter all
were characterized hj neuralgic pains in the lower extremi-
ties, and in three of them there were similar pains in the mus-
cles of the back and abdomen. In six there was spasm of
the neck of the Uadder, accompanied with severe pain, and
causing great difficulty of urinating, in one there was in-
continence of urine, in fiYe pain in the uterus and ovaries,
and in one neuralgia of the rectmn.

Motility was affected in eight cases. In four of these
there were strong tonic contractions of the muscles of the
lower extremities, and in four paralysis. In all of these
there were occasional clonic spasms simulating, chorea. Of
the nineteen cases in which there was also dorsal tender-
ness, the symptoms were in general those characteristic of
spinal iiTitation of both regions.

d. The whole spine was tender in fifteen cases, and so
extensive was the hypersesthesia that it was scarcely pos-
sible to press upon the most limited spot without producing
pain. Of these cases the most prominent symptom in three
was epilepsy, in one paralysis, sometimes of the upper and
sometimes of the lower extremities, and in three contrac-
tions of the limbs. Neuralgic pains, either in the scalp,
face, neck, chest, upper extremities, abdomen, and lower
extremities, were present in every case, according to the
part most severely affected for the time being. The
heart was disordered in five cases, the stomach in ten, in
three there was difficulty of swallowing, from alternating
paralysis, and spasm of the muscles of the larynx, and in
two aphonia.

Causes. — The most powerful predisposing cause is sex.
Of the one hundred and fifty-six cases, one hundred and
forty were females. Age is likewise influential in deter-
mining to the disorder. Of one hundred and thirty-seven
cases in which I have recorded the age, seventy-two were
between fifteen and twenty-five, thirty-two between twenty-
five and thirty -five, fifteen under fifteen, and eighteen over

416

DISEASES OF THE SPINAL CORD,

thirty-five. The period of life between fifteen and twenty-
five is therefore that at which spinal irritation is most apt
to occur.

Hereditary influence was ascertained to exist in thirty
cases.

The exciting cause of spinal irritation is not always easy
to ascertain. In thirty out of one hundred and thirty-seven
cases I could not, by the most careful inquiry, find any cir-
cumstance likely to have given it origin. In twenty-one it
was manifestly produced by blows, falls, or strains, in twelve
it was obviously caused by sexual excesses, and four by
onanism. In ten there was reason to ascribe it to anxiety
and grief, in two to excessive mental exertion, in twenty-
one to insufficient physical exercise, in fourteen to innu-
tritions and insufficient food, in three to over-indulgence in
alcoholic liquors, and in one to the use of opium. In the
remaining nineteen cases it followed exhausting diseases,
such as typhoid, scarlet, and intermittent fever, dysentery,
and diphtheria, and was probably directly the result of
their influence.

It may also be caused by obliteration of the aorta or
spinal vessels, by tumors, thrombosis, or embolism, by
haemorrhage from vessels in relation with those of the cord,
or by exposure to severe cold.

In general terms, it may be said that any cause capable
of reducing the powers of the system may produce spinal
irritation. •

Morbid Anatomy and Pathology. — I have already stated it
as my opinion that the essential condition of spinal irritation
is ansemia of the posterior columns of the cord. Other writers
have ascribed it to inflammation, congestion, hysteria, and
numerous other factors. The reasons which have induced
me to arrive at this conclusion are briefly as follows : Owing
to the fact tliat spinal irritation is not jper se a fatal disease,
we rarely have the opportunity to verify any views we may
hold in regard to its pathology. In the few cases in which

SPINAL ANEMIA, ETC.

417

post-mortem examinations were made, nothing abnormal
was found, a circumstance, however, far more compatible
with the idea I have expressed than with any other :

1. It is a well-recognized fact that irritation is often a
result of a deficient supply or a poor quality of blood. Thus
headaches are frequently caused by cerebral angemia, and
are promptly relieved by increasing the amount of blood in
the cerebral blood-vessels. Irritability of the mind is also a
constant accompaniment. A feebly-nourished stomach re-
jects food, and is the seat of pain. An anaemic heart beats
with great rapidity, weak muscles are affected with tremor,
and an exhausted generative system is brought into a state
of unnatural erethism by the slightest kind of excitation.
Analogy, therefore, supports the theory I have suggested.

2. The diagnosis of diseases of the spinal cord has be-
come so perfect that we are able to distinguish congestion,
meningitis, myelitis, softening, tumors, etc., by their symp-
toms and by the means of research at our command. We
see, therefore, that the morbid phenomena which result from
such conditions are not such as we now class under the head
of spinal irritation. This division of the subject will be
more fully considered under the head of diagnosis.

3. I have repeatedly ascertained, by actual experience,
that those ag-ents which are known to diminish the amount
of blood in the spinal vessels invariably increase the severity
of the symptoms due to spinal irritation, while they are as
effectually lessened in intensity by remedies which tend to
produce spinal hypersemia.

4. The general condition of patients the subjects of spi-
nal irritation is always below par, and the exciting causes
are all such as tend to the production of asthenia.

5. The character of the symptoms points decidedly to
the greater, and at times sole implication of the posterior
columns. There are cases of the disorder in which there is
no derangement of motility in any part of the body, and in
all cases aberrations of sensibility are the prominent fea-

418

DISEASES OF THE SPINAL CORD.

tures. Moreover, the viscera are generally affected in their
functions, a circumstance of itself strongly indicative of the
situation of the lesion in the posterior columns.

These circumstances, I think, go very far toward con-
firming the view I have expressed, that in spinal irritation
the vessels of the cord, especially those of the posterior col-
umns, contain less blood, and that this fluid is inferior in
quality to that when the organ is in a healthy condition.
Now that the function of the sympathetic nerve, as regards
its action in regulating the calibre of the blood-vessels, is so
satisfactorily proven, we can partially understand how local
congestions and anaemias may be superinduced. It is prob-
able, therefore, that the original difficulty in many cases of
spinal irritation resides in the sympathetic system, and the
intimate anatomical relations existing between the two ner-
vous centres are strongly in favor of this suggestion.

On the other hand, many of the phenomena of spinal
irritation point strongly to the secondary involvement of the
sympathetic system. It is thus that the visceral disturb-
ances which form such prominent features are mainly to be
explained.

The pathology of several others of the more striking
symptoms of spinal irritation has been a subject of frequent
discussion, but at the present day presents no difficulties.
Thus the excitation of pain in the tissues to which the cuta-
neous nerves are distributed results from the law that irri-
tation at a nervous centre induces pain at the points in
which the nerves arising from that centre end. Each com-
pound spinal nerve sends a twig to the skin contiguous to
it, and these twigs terminate immediately over the spinous
processes. Now, whenever an irritation is thus transmitted
to the periphery, it may be reflected back to the centre
whence it came, by local irritations. Thus a patient is suf-
fering from chronic inflammation of the spinal cord, and in
consequence has pain and muscular spasms in his lower ex-
trEmitieSu An irritation applied directly to the cord in-

SPINAL ANEMIA, ETC. 419

creases tlie pain and spasms ; an irritation applied to tlie
lower extremities augments the pain in the cord, and may
induce pain and spasms in distant parts of the body. Hence
it is that pressure on the skin over the spinous processes not
only causes cutaneous pain, but also gives rise to spinal pain,
and neuralgic sensations in those nerves which come from
the irritated part of the cord.

The pain existing in the cord is aggravated by percus-
sion or muscular action. The spinal cord, it is true, is en-
closed in a strong and thick, bony canal, which, however,
is entirely filled by its contents. A blow, therefore, on the
exterior of the column causes a vibration, which is propa-
gated through the bony structure to the cord and its mem-
branes. If this blow be very violent, the concussion may
be such as to inflict irreparable damage on the cord. When
any portion of the cord is in a state of irritation, a very light
blow upon the spinous processes, over the disordered part,
will cause severe pain, or notably add to that already pres-
ent. The vertebral column is flexible, and therefore mus-
cular action may, by producing deviations from the ordinary
line followed, occasion pressure, and, in the abnormal con-
dition of the cord, excite pain.

Diagnosis. — Recollecting that no case is to be regarded
as one of spinal irritation which is not characterized by
spinal tenderness, we have our diagnostic inquiries limited
to the distinguishing of spinal irritation from other spinal
afiections. It is certainly true that the distinction has often
been overlooked, and that at times there is a real difiiculty
in forming a correct judgment. Nevertheless, by carefully
estimating all the circumstances, permanent errors of diag-
nosis are not likely to occur.

There are three diseases of the spinal cord which may
in their earlier stages be confounded with simple spinal irri-
tation. These are chronic myelitis, meningitis, and con-
gestion. As the treatment of these affections is in many
respects the exact reverse of that proper for spinal irritation,

420

DISEASES OF THE SPINAL CORD.

and as they are of far more serious character, it is impor-
tant to make as early and as correct a discrimination as pos-
sible.

In both spinal irritation and myelitis there is tenderness
over some part of the vertebral column, which tenderness is
increased by pressure, but this tenderness is never due to
hypersesthesia of the skin, whereas in spinal irritation it
often is.

In spinal irritation there is never, so far as my experience
goes, anaesthesia, whereas this is a constant accompaniment
of myelitis.

The contractions which take place in some cases of spi-
nal irritation are painless, while those due to myelitis are
attended with great suffering.

In myelitis there is a sensation as if a tight cord were
tied around the body at the upper limit of the paralysis, a
sensation which is absent in spinal irritation. It is true
that Mr, Teale has described several cases which he classed
as spinal irritation and in which the sensation of constric-
tion was present, but careful examination of the histories
leaves scarcely a doubt that these were really cases of mye-
litis.

The bladder is never paralyzed in spinal irritation,
whereas in myelitis it generally is, if the inflammation be
located in the lower dorsal region of the cord. The same is
true of the sphincter ani. Myelitis is always productive of
paralysis, and there is always more or less atrophy of the
paralyzed muscles. Spinal irritation seldom gives rise to'
paralysis, which, when it does result, is always incomplete,
and is never productive of atrophy.

The progress of myelitis is generally, unless arrested by
appropriate treatment, toward a worse condition, whereas
no such tendency is manifested by spinal irritation.

From spinal meningitis, spinal irritation is distinguished
by the circumstances that in the former disease there are
constant painful spasms of the muscles of the back, pain

SPINAL ANEMIA, ETC.

421

in the cord, and no spinal tenderness increased by pres-
sure.

From congestion of the spinal cord and its membranes,
spinal irritation is sufficiently distinguished by the facts that
there is generally little or no pain in the cord in the first-
named affection, and no spinal tenderness. In congestion,
likewise, the paralysis and other symptoms are always worse
after the patient has been lying down, while in spinal irrita-
tion the recumbent position always alleviates the condition.

Another means, which in doubtful cases will invariably
lead to a correct diagnosis, is afforded by the known effects
of certain medicines. Thus spinal irritation is, as I have
several times ascertained, made worse by the administration
of ergot, while each one of the other diseases I have named
is alleviated. The reverse is true of strychnia, which in all
cases aggravates the symptoms of myelitis, meningitis, or
congestion, while it is an efficient means of cure in spinal
irritation. A hypodermic injection of the thirtieth of a
grain is sufficient to settle the matter in cases where the
diagnosis is of difficult formation.

The flatulence, eructations, and vomiting, are very symp-
tomatic of spinal irritation, while they are rarely phenom-
ena of either of the other affections.

One other disease is liable to be confounded with spinal
irritation, 5,nd that is angular curvature, in which there is
spinal tenderness increased by pressure. The facts, how-
ever, that strumous disease of the vertebrae generally occurs
in children, that the scrofulous diathesis is always present,
that an angular prominence can be detected by careful ex-
amination, that the paralysis progressively becomes more
profound, that the constitutional effects are more severe, are
sufficient, even in doubtful cases, to guide to a correct diag-
nosis.

Prognosis. — The prognosis in cases of spinal irritation is
generally favorable. In fact, so far as my experience ex-
tends, I have never seen a case which entirely resisted treat-

422

DISEASES OF THE SPINAL CORD.

ment, and very few in which a cure was not ultimately
effected. When remedies suitable for the difficulty do not
prove successful, it is because the patient does not stead-
fastly persevere in their use.

Of the one hundred and fifty-six cases forming the basis
of this chapter, one hundred and thirty-three were thorough-
ly cured, ten were lost sight of soon after treatment was
commenced, but were materially improved, and thirteen
were relieved for the time being, but continued to have re-
lapses.

Treatment. — The principles of treatment applicable to
spinal irritation are four ;

1. To remove the cause.

2. To improve the general tone of the system.

3. To increase the amount of blood in the spinal cord,
and improve the nutrition of this organ.

4. To set up a counter-irritant action in the vicinity of
the disordered region of the cord.

In regard to the first indication, I have nothing special
to say. The cause once ascertained, common-sense w^ould
dictate its removal as speedily and as effectually as possible,
by the proper means according to its character.

The second indication is to be met by tonics, such as
quinine and iron, and especially stimulants judiciously ad-
ministered. I am as well convinced of the general applica-
bility of alcohol in some form, in the treatment of spinal
irritation, as I am of any thing. Whiskey, brandy, and
rum, are to be preferred on account of their less liability to
disagree with the stomach, and as containing a greater per-
centage of alcohol than vinous or malt liquors. Among the
tonics the preparations of zinc are valuable, and I think the
oxide is to be preferred. Cod-liver oil is also of great ser-
vice.

The third indication is easily fulfilled by strychnia, phos-
phorus, phosphoric acid, and opium. The two first-named
remedies may be very satisfactorily combined in a pill con-

SPINAL ANiEMIA, ETC.

423

taining half a grain of extract of nux-vomica and the tenth
of a grain of the phosphide of zinc, which may be given
three times a day. Strychnia may also be given by solution
of the sulphate in dilute phosphoric acid, and in doses of
about the thirty-second of a grain to half a drachm of the
acid. The beneficial efiects of these remedies are perceived
in a few days. Opium is especially useful in those cases in
which there are contractions of the limbs, and here it§ ac-
tion is, of course, not solely that of an agent increasing the
amount of blood in the cord. I prefer to give it either in
the form of suppositories, composed each of half a grain of
the aqueous extract and a sufficient quantity of the butter
of cacao, or by hypodermic injection of morphia. I have
frequently seen contractions, w^hich had persisted with obsti-
nacy for several wrecks, relax in a few minutes under the in-
fluence of opium thus administered.

The application of hot water to the spine is also an ad-
mirable adjuvant. It should be used as hot as can be borne.
Nothing is better for the purpose than Dr. Chapman's india-
rubber bags.

But there is a remedy which apparently either contracts
or enlarges the diameter of the blood-vessels, and which is
more efficacious in removing spinal irritation than any other
with which I am acquainted, and that is tlie direct galvanic
current. The method I follow in cases of spinal irritation
is the application of the negative pole at some point above
the seat of the pain, and the positive at another, an equal
distance below. An ascending current is thus brought to
bear upon the cord, and this seemingly conduces to the dila-
tation of the blood-vessels and the improvement of the nu-
trition of the cord. The current should not be passed at
any one seance for more than fifteen minutes, and no one
application should last longer than three or four minutes.
For the relief of the spinal tenderness the negative pole
should be applied directly to the painful part, and the posi-
tive to a point distant laterally from it a few inches.

424

DISEASES or THE SPINAL CORD.

In inflammation or congestion of the cord or its menin-
ges, the method of application is directly the reverse of
this.

The fourth indication is one of great importance, and,
when properly carried into etfect, a cure will often result in
slight cases without any other means of treatment being
employed. The rationale of the action of counter-irritants
in this and similar derangements is by no means clearly un-
derstood. It is a question which I do not, however, propose
to discuss. Of counter-irritants my experience leads me de-
cidedly to the employment of blisters in preference to any
others. They should be applied to the skin, immediately
over the painful part of the spine, and should be renewed
as often as may be necessary. Tartar-emetic ointment,
though useful, is more painful and I think not so efficacious
as blisters. Dry cups are more admissible, and almost al-
ways do good. They should be applied on each side of the
spinous processes for an extent of four or five inches above
and below the painful spot. Leeches, or any other means
for the abstraction of blood are, according to my experience,
always prejudicial.

Besides these therapeutical means, there are others of a
more strictly hygienic character, which cannot be over-
looked. Thus the food should be of a highly-nutritious
character, moderate physical exercise should be taken, and
as much time as possible should be spent in the open air.

Patients almost always feel more comfortable in the re-
cumbent position than any other, because thereby the blood
is allowed to settle in the spinal vessels. They should not
therefore be prevented lying down during the greater part
of the day, but at the same time they should be encouraged
to take exercise, and especially so when there is any loss of
power in the lower extremities. The induced or faradaic
current is almost always of service, when applied to the
affected muscles, and the direct is of great efficacy when
passed through neuralgic nervous trunks.

SPINAL ANEMIA, ETC.

425

In illustration of the views inculcated in tliis memoir, I
append the following details of cases :

Case I. Irritation of the Cervical Region of the Spinal
Cord. — Mrs. J. S. consulted me, May Y, 1868, for what she
had been informed was a cerebral disorder. The patient
was thirty-eight years of age, had had five children, and
had always enjoyed good health till two years previously,
when she had been thrown from her carriage. She was not
stunned or otherwise seriously injured. Soon after the acci-
dent she noticed a rumbling noise in one ear, and in a few
days subsequently the other ear became similarly affected.
About the same time there were flashes of light before the
eyes, and a dull, heavy pain in this point of the head. "Ver-
tigo was also frequently present. There was insomnia, and
when she did sleep she was very apt to be attacked with
nightmare.

These symptoms continued to annoy her for several
months, without, however, compelling her to seek for medi-
cal advice, until at last she had a seizure which was certainly
epileptic in its character. This was followed with disturb-
ance of vision, and intense neuralgia of the fifth pair of
nerves. She now placed herself under the charge of a phy-
sician in a neighboring city, where she was then residing,
who diagnosed a tumor of the brain, and gave an unfavor-
able opinion as- to the ultimate result. He, however, ad-
vised the use of iodide of potassium. She took this in large
doses faithfully for three months — during which period she
had two more epileptic attacks — without perceiving any
benefit, and then she went to Europe. While there she
consulted a number of physicians and surgeons of eminence,
all of whom gave a very guarded prognosis. By the advice
of several of these she took the bromide of potassium, with,
at first, some advantage, but this was eventually lost, and
her symptoms became as severe as before. She had several
epileptic paroxysms during the four months she was taking
the bromide. Finally, she travelled through Germany and

426

DISEASES OF THE SPINAL CORD.

Italy, and, still obtaining no relief, returned liome. I saw
her a few days after her arrival. She was then suffering
from facial neuralgia, excessive tenderness of the scalp, so
that she could not have her hair brushed without enduring
great pain, obscureness of vision, pain in the eyeballs, red-
ness of the conjunctivae, vertigo almost constantly, great
mental irritability, amounting at times to positive insanity;
wakefulness, nightmare, and contraction of the fingers, the
nails being strongly pressed against the palm of the hand.

Ophthalmoscopic examination showed dilatation of the
retinal vessels, arterial and venous pulsation, and congestion
of the optic disks of both eyes. The ■ pupils of both eyes
were contracted.

Perhaps I should riot have suspected any spinal diffi-
culty, if she had not herself called my attention to a pain
which she said she constantly felt between the shoulders.
I therefore examined the upper part of the spine very care-
fully, and found deep-seated pain developed by percussion
over the seventh cervical vertebra, and great hyperaesthesia
of the skin over the eighth. Her symptoms were not those
in the least indicative of congestion of the cord or its mem-
branes, of meningitis, or myelitis, and the apparent severity
of the cerebral symptoms, and the general good condition
of her mind and sensorial and motor functions, were so
incompatible, that I could not, upon reflection, bring myself
to the belief that she was affected with any organic disease
of the brain. My inquiries and examinations all led me to
the conclusion that she was laboring under spinal irritation
of the lower cervical region.

I therefore prescribed for her five drops of the phos-
phorated oil three times a day, applied a blister to the pain-
ful spot, and daily passed the direct galvanic current through
the cord, by applying the negative pole to the fifth cervical,
and the positive to the sixth dorsal. My object was, not
only to improve the nutrition of the cord, but also, by irri-
tation of the sympathetic, to contract the vessels of the

SPINAL ANEMIA, ETC.

427

brain. Budge and "Waller had shown, several years pre-
viously, that, when that portion of the spina] cord situated
between the seventh cervical and sixth dorsal vertebrae is
acted upon by tlie galvanic current, the pupils are dilated.
Now, dilatation of the pupils is produced hy excitation of
the sympathetic, and excitation of the sympathetic within
the limits mentioned likewise causes contraction of the ves-
sels of the brain, as can readily be seen by ophthalmoscopic
examination while the current is passing.

Under the influence of this treatment the amendment
was rapid, and at the end of three months she was entirely
cured. It was necessary, however, to apply eleven blisters.

Case II. Irritation of tlie Cervical Region of the Cord.
— M, S., a gentleman of sedentary habits, consulted me,
August, 1867, for intense headache and facial neuralgia,
with which he had suffered for several months. The disease
had come on gradually, and, although now never entirely
absent, was paroxysmal in its character, being more severe
at night than through the day. The external pain followed
the course of the fifth pair of nerves through all its branches ;
the internal was fixed in the posterior part of the head, and
was evidently due to cerebral anaemia, as it was relieved by
stimulants and by holding the head in a dependent position.
Yertigo was frequently present, and the disposition to sleep
was excessive, though, owing to the pain, could not be in-
dulged in for more than a few minutes at a time. Nausea
was occasionally a symptom, but never to the extent of being
followed by vomiting.

On examining the spine of this gentleman, I found ten-
derness over the fourth and seventh cervical vertebrae. Two
blisters were at once applied, and Aitken's syrup of the
phosphate of iron, quinine, and strychnia, administered.
From the first, improvement was manifested, and in less
than a month the cure was complete.

Case III. Irritation of the Dorsal Region of the Spinal
Cord. — Mrs. J. B., aged twenty-four, consulted me, March,

428

DISEASES OF THE SPINAL CORD.

1868, for obstinate vomiting, and neuralgic pains in the left
breast. She was thin, pale, and anaemic, and had suffered
for over a year. She also complained of a dull, aching pain
in the middle of the back, which was increased by even
moderate physical exercise. The vomiting took place regu-
larly after every meal, and even water was at once thrown
up. She was under the impression that the disorder was
the result of exposure for several hours to very severe cold
while in an open boat.

Recognizing, at once, the fact that the main difficulty
lay in the cord, I carefully examined the whole spine, and
found excessive tenderness over the spinous processes of the
sixth, seventh, and eighth dorsal vertebrae. There was also
deep-seated spinal pain developed by percussion.

I ordered the application of a blister, and the internal
use of small quantities, frequently repeated, of milk-punch
(one ounce of brandy to three of milk). The first wineglass-
ful was at once rejected, and so was a tablespoonful which
she took half an hour subsequently. I then reduced the
quantity to a teaspoonful every half hour. Tliis was re-
tained, and was the first nutriment of any kind which, for
nearly eleven months, had not been rejected wholly or in
part.

The next day I found that the blister had drawn well,
and that the nausea and vomiting were greatly diminished,
as were likewise the neuralgic pains. A teaspoonful of the
following mixture was then directed to be taken three times
a day, immediately after meals: 1^. Strychniae sulph. gr. j,
ferri pyrophosph., quiuiae sulph. aa. 3ss, acid phosph. dil.,
syrupus zingiberis aa. ^ij- ft- mist. The milk-punch
was still continued, but, in treble the dose, less frequently
given.

Gradually all the symptoms decreased in violence, and
at the end of two weeks she was enabled to retain a mod-
erate quantity of food at each meal. Any excess was still,
however, followed by vomiting. She had increased five

SPINAL ANAEMIA, ETC.

429

pounds in weight, and was greatly improved in personal
appearance.

In two months she had gained twenty-one pounds, and
was as well as she had ever been in her life. The spinal ten-
derness had entirely disappeared ; seven blisters were ap-
plied in all.

Case IY. Irritation of the Dorsal Region of the Spinal
Cord. — Mrs. TV. had for more than three years suffered from
spasmodic movements of the upper extremities, not distin-
guishable from those of true chorea, which occasionally were
followed by contractions of the flexors of the wrists and fin-
gers. There were also infra-mammary pain, eructations,
and vomiting. When she came under my care, June 22,
1869, she was reduced to almost a skeleton, and was sufier-
ing, in addition to the symptoms above mentioned, from
acute pain in the back. This pain she informed me had not
been ordinarily very severe, but was, nevertheless, constant-
ly present. On examination I found tenderness over the
first, second, and third dorsal vertebrae. I at once applied
the constant galvanic current in the manner already de-
scribed, and continued it for five minutes, with the effect of
mitigating the pain in the spine and the nausea. The en-
suing day I repeated the application, and in addition pre-
scribed the mixture given in Case III. She retained it on
her stomach, as she did the food which she ate that day.
Brandy in ounce-doses was given with her lunch and dinner.
The galvanism was continued daily for eighteen days, at the
end of which time she was free from pain, from the spasms,
and from the vomiting. Her appearance was immensely
improved, and she had increased seven pounds in weight.
The galvanism was now discontinued, but the strychnia
mixture and the brandy were persevered with for over a
month longer. She was then well.

Case V. Irritation of the Lumbar Region of the Spinal
Cord. — E. T., an unmarried lady, aged twenty-nine, con-
sulted me, August, 1869, for paralysis of the lower extremi-

430

DISEASES OF THE SPINAL CORD.

ties, attended with spinal tenderness and abdominal pains.
She had been treated for inflammation of the spinal cord,
had been cupped, leeched, and had had an issue made over
the seat of the pain.

When I first saw her she was unable to walk, having
been in this condition for several months. As she sat in her
chair, she could readily move her legs in any desired direc-
tion, but to bear her weight upon them was an utter im-
possibility. There was no alteration of sensibility. Her
general appearance was not anaemic, nor was she in the
least degree hysterical. Upon careful examination, I was
unable to find any reason to induce the belief that she was
laboring under spinal congestion, meningitis, or myelitis,
or that there was softening of, or pressure upon, the cord.
I, however, discovered great tenderness over the first and
second lumbar vertebrae, and found that strong pressure in
this region induced deep-seated spinal pain and sharp neu-
ralgic sensations along the course of the crural nerves.

Regarding the case as one of pure spinal irritation, I ap-
plied the constant galvanic current to the back every alter-
nate day, and administered the following prescription :
Zinci phosphidi, grs. iij, ext. nucis vom. grs. xv. M. ft. in
pil. no. XXX. Dose, one three times a day. I likewise di-
rected the application, to the painful part of the spine, of
flannel, wrung out of spirits of turpentine, to be continued
daily till redness and decided smarting were produced. A
full and nutritious diet, with ale, was enjoined. Under this
treatment she improved so rapidly in every respect that in
twenty-three days she was able to walk with a cane, and in
a few days more than a month was well, being in as good
health, according to her own report, as she had ever enjoyed
in her life.

ANiElvnA or THE ANTERO-LATEEAL COLUMNS OF THE CORD.

The phenomena which in my opinion are the result of an
anaemic condition of the antero-lateral columns of the spinal

SPINAL ANEMIA, ETC.

431

cord have hitherto been classed under the heads of spinal
paresis, functional paralysis, reflex paralysis, inliibitory pa-
ralysis, paralysis from peripheral irritation, etc. Several of
these names are applied with reference to the causes, others
with reference to the symptoms, but none to the lesion.

Ssanptoms. — The most prominent symptom of anaemia of
the antero-lateral columns of the spinal cord is paralysis of
motion in those parts of the body which derive their nerves
from the affected portion of the cord, and in many cases of
those below the seat of the lesion. This paralysis is incom-
plete, the patient, if the lower extremities are affected, being
able to walk, though he does so with difiiculty. It is no-
ticed, too, that some muscles are more apt to be paralyzed
than others, the tibialis anticus and the peroneal group
rarely escaping.

In the great majority of cases the paralysis is confined to
the lower extremities, constituting paraplegia. The reason
for this is, that the anaemic condition of the cord which
causes the paralysis is more frequently excited by irritation
transmitted from the genito-urinary and digestive organs
than from any others.

Spasmodic contractions of the paralyzed muscles are not
often met with, though occasionally there are slight twitch-
ings, fibrillary in their character.

It is rarely the case that the paralysis extends, as it does
in that which results from congestion of the cord. The af-
fection usually supervenes suddenly, and is about as severe
in the beginning as at any subsequent period.

The bladder and rectum are very rarely involved as a
consequence of the spinal lesion, though disease of either
of these organs often causes anaemia of the antero-lateral
columns of the cord. In a few cases, however, I have wit-
nessed both paralysis of the bladder and of the sphincter
coming on late in the course of the disease, and evidently
dependent on it.

Electro-muscular irritability is rarely impaired. Reflex

432

DISEASES OF THE SPINAL CORD.

excitability is also generally unaffected. In the worst cases,
tickling the sole of the foot will cause the leg to be drawn
up, even against the volition of the patient.

Disorders of sensibility are not prominent features in
anaemia of the antero-lateral columns of the spinal cord.
Locally there is very rarely pain, and in the paralyzed parts
there is neither anaesthesia, hypersesthesia, nor abnormal sen-
sations of any kind. There is never, in the uncomplicated
affection, the sensation of constriction about any part of the
body. Tlie stomach and bowels are not often affected, un-
less there is at the same time some degree of anaemia of the
posterior columns. But in one very interesting case, occur-
ring in a lady of this city, and produced by exposure to ex-
treme cold while crossing to Governor's Island in an open
boat, there were vomiting every time food was taken into
the stomach, and the most obstinate constipation I have
ever witnessed. It very frequently happened that this lady
had no operation from her bowels for over a month.

Causes. — Anaemia of the antero-lateral columns of the
spinal cord may be produced by any cause capable of inter-
rupting the flow of blood to the region in question, of less-
ening the calibre of its autocthonous arteries, or of so lower-
ing the quality of the blood as to unfit it for the purposes
of nutrition.

Thus it may be caused — though not without the impli-
cation of the posterior columns — ^by abdominal tumors com-
pressing the aorta, or by disease of this vessel, leading to
partial or complete obliteration ; by thrombosis or embolism
of the spinal arteries ; or by direct loss of blood from vessels
supplying the cord, or deriving their blood from the spinal
vessels.

The calibre of the intra- spinal vessels may be lessened
through the influence of extreme cold, and anaemia of the
antero-lateral columns thus induced. Several cases of this
kind have come under my care, in which paraplegia has
supervened suddenly during or after exjjosure to very low

SPINAL ANEMIA, ETC.

433

temperature, especially when combined with a moist state
of the atmosphere. Lying on damp ground has caused it in
a number of instances.

It not unfrequently follows exhausting diseases of various
kinds. I have known it to supervene on dysentery, diar-
rhoea, cholera, typhoid fever, typhus, diphtheria, and several
other affections.

But the most common cause of the disorder is undoubt-
edly peripheral irritation, and this is very frequently an
affection of the genito-urinary organs. My friend Dr. S.
"Weir Mitchell ' has written very exhaustively on this sub-
ject, and has shown the relation which exists between the
different paralyses now usually called reflex, and injuries of
nerves. Under the head of pathology I shall have occasion
to return to Dr. Mitchell's valuable contributions.

Diagnosis. — Anaemia of the antero-lateral columns of the
cord is distinguished from congestion by the facts that the
symptoms are mitigated by the recumbent position instead
of being increased in violence, as in the latter affection ;
that the paralysis shows no tendency to become more severe,
and that, when the bladder or rectum is involved, the diffi-
culty precedes the paralysis.

From anaemia of the posterior columns, it is diagnosti-
cated by the fact that the more obvious symptoms are related
to motility, sensibility not being involved, while in the for-
mer the reverse is the case.

The diagnosis from myelitis will be pointed out when
inflammation of the cord is under consideration.

Prognosis. — The probability of a favorable termination is
great. In fact, no affection of the cord is so susceptible of
cure when there is no mechanical obstruction in the aorta
or spinal arteries. But this opinion is expressed with the

' Circular No. 6, 1864, Surgeon-General's Office. Reflex Paralysis, by Drs.
Mitchell, Morehouse, and Keen. Also Wounds and Injuries of Nerves by the
same, Philadelphia, 1864. Also Paralysis from Peripheral Irritation, by Dr.
Mitchell, New York Medical Journal, February, 1866.
28

434

DISEASES OF THE SPINAL CORD.

understanding that the cause must first be removed. So
long as this continues in action, anaemia of the antero-lateral
columns of the cord is a very obstinate afiection. When
the arteries are obstructed, then, as in'tlie brain under like
conditions, softening of the cord may take place.

Morbid Anatomy and Pathology. — Post-mortem examina-
tion, of persons who have suffered with symptoms indicative
of what I consider to be anaemia of the antero-lateral col-
umns of the cord, does not reveal the existence of any ma-
terial spinal lesion. The reason for this is that anaemia of
the cord is, in the nature of things, a very difficult disease to
detect, and cannot be definitely made out, unless the capil-
laries are measured under the microscope.

But it is this very absence of obvious lesions which indi-
cates very positively the existence of anaemia, and the char-
acter of the symptoms shows that the antero-lateral columns
are its seat.

Several varieties of paralysis result from anaemia of the
antero-lateral columns. Classing these as Mitchell' has
done, from their apparent causes, we find that there are —

1. Paralyses arising during disease of the genito-urinary
organs.

2. Those which occur during or just after dysenteries,
diarrhoeas, super-purgation, or in connection with worms.

3. Such as arise during or after pneumonia or pleurisy.

4. Such as are seemingly brought on by dentition.

5. The paralysis of diphtheria, fevers, and eruptive dis-
orders.

6. Such as seems to be occasioned by cold, or by cold
and moisture.

7. Paralysis due to external injury.
To this list may be added —

8. Paralysis resulting from certain medicines and drugs.

9. Paralysis due to great emotional disturbance.

> Paralysis from Peripheral Irritation, with Reports of Cases, New York
Medical Journal, February, 1866, p. 323.

SPINAL ANJEMIA, ETC.

435

Many cases of each of these varieties of paralysis have
come under my notice, and there are few medical practi-
tioners wlio have not witnessed instances referable to one
or more of the foregoing categories. The principal theories
of their immediate cause are —

1. That of Mr. Stanley,' by which certain varieties of
paralysis are attributed to the transmissal of an irritation
from a diseased organ to the spinal cord, whence it is re-
flected to the muscles as paralysis.

This is no explanation at all, and leaves the condition of
the cord out of consideration. There is no proof whatever
that an irritation can, without causing change in the struct-
ure of a nervous centre, induce either paralysis of motion
or of sensation.

2. That of Dr. Brown-Sequard,'^ which ascribes the affec-
tions in question to a lesion of the cord, consisting in a
spasm of the spinal vessels by which their calibre is dimin-
ished. This spasm is, according to this eminent neurologist,
the result of a peripheral irritation transmitted through the
nerves coming from a diseased organ or part of the body, to
the vaso- motor nerves of the portion of the cord giving ori-
gin to these nerves.

This was, so far as I have been able to ascertain, the first
attempt to designate the character of the lesion, which, as
will be at once perceived, is anaemia. That anaemia can be
induced by peripheral irritation is, I think, well established.
But though this theory accounts for many cases of spinal
paralysis, such as are now under notice, it will not embrace
all, for we may have anemia and consequent loss of motor
power resulting from other causes than irritation. More-
over, Dr. Brown-Sequard did not fix the lesion in the
antero-lateral columns, nor associate the symptoms with

• On Irritation of the Spinal Cord and its Nerves in Connection with Disease
of the Kidneys, Medico-Chirurgical Transactions, vol. xviii., p. 260.

' Lectures on the Diagnosis and Treatment of the Principal Forms of Paral-
ysis of the Lower Extremities, Philadelphia, 1861.

436

DISEASES OF THE SPINAL CORD.

any derangement in the structure of this region of the
cord.

3. Dr. Mitchell, in the paper to which I have already
referred, divides the several kinds of paralysis mentioned
into three classes : those which are asserted to be due to dis-
ease of the genito-urinary system, a cause which he denies
in toto J those which are said to be produced by peripheral
irritation of the intestinal canal, an influence which he also
in great part denies ; and those which follow wounds and
injuries of nerves.

Dr. Mitchell rejects altogether the reflex theory of Dr.
Brown-Sequard, and says :

" If I were now to sum up the probabilities in the way
of causation of palsies peripherally induced, I should be dis-
posed to refer some cases to exhaustion from too constant or
excessive exercise of normal functions, and others to irrita-
tion from disease or injury, and to consequent exhaustion
of the centres ; while, as regards the intervention of vascular
agency, I should reject the idea of prolonged vasal spasm,
and consider it possible that in some instances over-excita-
tion might result in dilatation of the vessels, in which case
some material lesion would surely result if the condition in
question were of long continuance."

"While not prepared to accept Dr. Mitchell's views in their
entirety, they are, in my opinion, perfectly in accordance
with the doctrine of anaemia of the antero-lateral columns.
As to whether this anaemia is the result of spasm of the spi-
nal vessels, or exhaustion, is a question which, for the pres-
ent at least, is not definitely settled. My own opinion is
that paralyses of apparently peripheral origin are referable
to anaemia, produced in some cases by vaso-motor spasm,
and in others by nervous exhaustion.

The experiments of Kiissmaul and Tenner ' are perfectly
conclusive as to the effects of cutting off the supply of blood

' The Nature and Origin of Epileptiform Convulsions caused by Profuse
Bleeding, etc. New Sydenham Society Translations, London, 1859, p. 53, c< seq.

SPINAL ANEMIA, ETC.

437

to the spinal cord. These observers compressed the aorta
in rabbits so completely that not a drop of blood could reach
the spinal cord below the point of occlusion. The conse-
quence was that there was complete paralysis of all the mus-
cles receiving their nervous influence from the anaemic por-
tion of the cord. The possibility, therefore, of spinal anae-
mia producing paralysis, is beyond doubt. In these experi-
ments, however, the blood was of course shut off from both
the anterior and posterior columns, and therefore the phe-
nomena were not those of simple motor paralysis.

In practice, likewise, we often find that the anaemia
is not restricted to either set of columns, and that the
symptoms are accordingly those of motor paralysis, aber-
rations of sensibility, and functional disturbances in various
organs, such as we have just considered as being caused by
anaemia of the posterior columns.

Treatment. — The treatment is similar in general features
to that applicable to anaemia of the posterior columns al-
ready considered, though there is not the same benefit to be
derived from counter-irritation. The indications, therefore,
are to remove the cause, to improve the general tone of the
system, and to increase the amount of blood in the spinal
vessels.

So far as the first indication is concerned, it very often
happens that its fulfilment is suflicient for the entire re-
moval of the anaemia, and the disappearance of the conse-
quent paralysis. This is especially the case as regards those
instances which are due to peripheral irritations of various
kinds. Within the last few days a young lady, aged twelve,
was brought to me by her mother to be treated for para-
plegia, which had developed very suddenly. There was no
evidence of serious organic difiiculty, and no apparent cause
of peripheral irritation. Her symptoms, however, all point-
ed to anaemia of the antero-lateral columns, and, on the
principle of exclusion, I thought it probable there might be
worms in the alimentary canal. I therefore administered

438

DISEASES OF THE SPINAL CORD.

several doses of santonine, followed by castor-oil. A num-
ber of lumbrici were discharged, and the paralysis disap-
peared in the night as suddenly as it had arisen.

In another case, a gentleman was rendered paraplegic
soon after contracting a catarrhal inflammation of the blad-
der. The bladder alfection was disregarded by his physi-
cian, and energetic means were used against the paralysis,
but without effect. I suggested the expediency of suspend-
ing the administration of the strychnia and the application
of counter-irritants to the spine, and directing attention to
the cure of the bladder difficulty. This was done, and, at
the same rate as the inflammation yielded to the treatment,
the paraplegia disappeared.

The general tone of the system is to be improved by
such measures as were recommended for the accomplishment
of the same end in anaemia of the posterior columns.

For fulfilling the third indication, strychnia and phos-
phorus are preferable to any internal remedies. I usually
prescribe them together in doses of the tenth of a grain of
the phosphide of zinc, with from a third to a half a grain of
the extract of nux-vomica in pill, to be taken three times a
day. Lately, however, I have pursued the practice of giv-
ing the strychnia in gradually-increasing doses till there is
evidence of its characteristic physiological effects being pro-
duced. Two grains of the sulphate of strychnia are to be
dissolved in an ounce of water, and ten minims, containing
one twenty-fourth of a grain of strychnia, given three times
a day ; the next day eleven minims are administered for
each dose, the next twelve, and so on till, as often happens,
the paralysis yields, or till the reflex excitability of the legs
is increased, or stiffness of their muscles or those of the
nucha is induced. In either of these latter events the ad-
ministration must be stopped for a day, and then the original
dose of ten minims be given and increased as before. There
is, according to my experience, no medication so effectual in
all those forms of paralysis called reflex, inhibitory, func-

SPINAL ANJEMIA, ETC.

439

tioiial, etc., and which, in my opinion, result from anaemia
of the antero-lateral columns of the cord, as this with
strychnia. It requires care and prudence, and, if these
qualities be exercised, is perfectly safe. It very generally
happens that, before the patient reaches thirty minims (one-
eighth of a grain) for a dose, the paralysis begins to yield.
In one case, however, due to exposure to severe cold, I was
obliged to carry the dose to sixty minims — equal to one-
fourth of a grain of strychnia — ^before the excitability of the
cord was increased, or any signs of the paralysis yielding
were observed. The patient recovered after taking three-
quarters of a grain of strychnia daily for over two weeks.

My notes show that in the last year I have treated, ac-
cording to the method described, sixty -one cases of paralysis
due to anaemia of the antero-lateral columns, and that all
were cured. It is true, galvanism was used in some of
them, and phosphorus in others, but the successful results
were evidently mainly due to the strychnia.

The only local application which is decidedly beneficial
is the constant galvanic current, which should be used in
the manner recommended for ansemia of the posterior col-
umns.

As regards the paralyzed muscles, the induced or fara-
daic current is useful in keeping them exercised, and thus
preserving their nutrition. Friction and kneading exercise
a like efiect.

In those cases of spinal anaemia due to obstruction of the
aorta, or occlusion of spinal vessels by emboli, no specific
treatment is of any avail.

CHAPTER III.

SPINAL HEMORRHAGE— SPINAL MENINGEAL
HEMORBHA GE.

These two conditions having a common cause, being
often associated and having a general resemblance to each
other, may properly be considered together.

Symptoms. — A hseraorrhage into the substance of the
spinal cord is characterized by pain at the seat of the lesion,
and by derangements of sensibility and of the power of mo-
tion in all those parts of the body below. These consist or-
dinarily of anaesthesia and loss of motility, but occasionally
there are liyperaesthesia and spasms. In the great majority
of cases the bladder and its sphincter and the sphincter ani
are also paralyzed. Keflex excitability and electro-muscular
contractility are soon impaired or altogether lost.

If the seat of the haemorrhage be high up in the neck,
death is almost instantaneous from the paralysis of the phre-
nic nerve.

When the lesion is meningeal, the symptoms are not gen-
erally so rapidly developed as when it is situated in the sub-
stance of the cord. The pain is greater and there is a more
decided tendency to spasmodic jerkings in the limbs receiv-
ing their nerves from the part of the cord below the extrava-
sation. Hyperaesthesia may alternate with anaesthesia, or
this latter may alone be present.

The extent of motor paralysis is very variable, both as
regards intensity and diffusion. Sometimes all the muscles
below the seat of the lesion are more or less paralyzed ; at

SPINAL HAEMORRHAGE, ETC.

441

others, some muscles altogether escape. I have a patient at
the present time under treatment who has, in consequence
of a spinal heemorrhage, probably meningeal, lost sensation
in a small region of skin over the glutei muscles, and sensa-
tion and motion in all the tissues below both knees. Sensa-
tion and motion are intact in all other parts of the lower
extremities. The bladder is unaffected, but there is very
obstinate constipation.

Reflex excitability is often exaggerated, and the electro-
muscular contractility increased in the early stage ; but, if
the patient survives the immediate effects of the lesion, both
these faculties become impaired. Meningeal haemorrhage
taking place above the third cervical vertebra may be
speedily fatal, from the interruption to respiration due to
paralysis of the phrenic nerve.

Causes. — Spinal haemorrhage, either in the substance of
the cord or of the membranes, is almost invariably the result
of injury. Thus it may be caused by blows on the verte-
bral column, by falls, or by gunshot, or by wounds with pen-
etrating instruments. It may also be produced by tetanus
and by the rupture of aneurisms, but is in either of these
cases meningeal.

Diagnosis. — The diagnosis must mainly be determined by
the history of the case, and by the facts that the symptoms
come on suddenly and advance rapidly.

Prognosis. — Death is the almost invariable result. I have,
however, known two instances of recovery. In one of these
the patient, a boy of about fifteen, was thrown from his
horse. Paralysis supervened immediately, and there was a
severe pain at about the eleventh dorsal vertebra. The
bladder was also paralyzed. For several weeks his life was
despaired of, but he eventually recovered with the para-
plegia remaining, and the necessity of drawing off the urine
with a catheter. I saw him five years after the injury. He
was still paraplegic, and the bladder was still paralyzed.
Careful examination failed to show any displacement or

442

DISEASES OF THE SPINAL CORD.

fracture of the vertebra, and I therefore felt warranted in
concluding that there had been a spinal haemorrhage, prob-
ably meningeal. The other case has been already cited. In
this, the patient fell through a hatchway a distance of thirty
feet, and struck on his back. Paralysis was almost immedi-
ate. He came under my care fifteen years after the event,
and I diagnosticated a meningeal spinal haemorrhage from
the facts that there had been violent jerkings of the limbs
and intense lumbar pain. There were no signs of fracture
or displacement.

Morbid Anatomy and Pathology. — The extravasation in
haemorrhage into the substance of the cord is generally
seated in the gray matter, and shows a greater tendency to
extend longitudinally than laterally. The white matter is,
however, occasionally involved.

The changes which ensue in the clot and in the limiting
tissue are similar to those which take place in cerebral haem-
orrhage.

In spinal meningeal haemorrhage the blood is extrava-
sated either between the bones and the dura mater, between
the dura mater and the arachnoid, or between the arachnoid
and the pia mater. The clot may be very small or very
large. The latter is more frequently the case.

The symptoms which follow spinal haemorrhage are the
results of excitation and compression — the hypersesthesia
and the spasms being due to the former, and the anaesthesia
and motor paralysis to the latter.

Treatment. — There is nothing to do in cases of spinal
haemorrhage but to maintain the patient in as quiet a con-
dition as possible, and to keep ice constantly applied to the
vertebral column. If there is time, ergot might, I think, be
administered with advantage. In two cases which I have
had the opportunity of observing from the first, both caused
by falls from the loft of a stable, death took place within
six hours ; the symptoms gradually becoming more profound
and advancing upward. After death, the haemorrhage was

SPINAL HEMORRHAGE, ETC.

443

found to occupy the whole length of the spinal canal, and
was seated between the bones and the dura mater. Of
course, in cases like these, no therapeutical means can avail,
and, even in slighter cases, treatment is of little if any ser-
vice.

We may, however, by perfect rest, ice to the spine,
leeches to the anus, and the administration of ergot, some-
times prevent haemorrhage in cases of injuries of the cord
which otherwise might be followed by extravasation.

CHAPTER lY.

SPINAL MENINGITIS.

Inflammation of the membranes of the spinal cord may
be either acute or chronic.

ACUTE SPINAL MENINGITIS.

Acute inflammation may be seated either in the dura
mater, the arachnoid, or the pia mater of the cord, or may
simultaneously attack all three membranes.

Symptoms. — The symptoms indicating inflammation of
the dura mater are not very decided, and beyond the occur-
rence of pain may not be observed at all. "When combined
with inflammation of the arachnoid and pia mater, the phe-
nomena are more pronounced.

Acute inflammation of the arachnoid does not of itself
give rise to characteristic symptoms, and it is rarely the
case that it exists separately.

Acute inflammation of the pia mater can, however, be
recognized without diflficulty. It begins with a chill, as do
others of the phlegmasise, and this is soon followed by fe-
brile excitement. At the same time there is intense pain in
the back, which is aggravated by every movement of the
patient, but not by pressure on the part of the spine
over the diseased portion of the membrane. Those nerves
which have their origins from the affected region are the
seat of severe pain, which is transmitted through their
trunks and branches to distant parts of the body. Spasms
of the muscles of the back are commonly present. These

SPINAL MENINGITIS.

445

are tonic in character, and may be so severe as to bend the
body backward, producing an appearance like the opisthot-
onos of tetanus. At the same time the limbs below the
seat of the lesion are strongly contracted. I have witnessed
cases in which the knees were drawn up to the chin, and
the heels to the buttocks.

At the same time there is impairment of motor power in
all those parts of the body supplied by nerves coming from
the cord below the diseased region, and in some cases volun-
tary control over the muscles is entirely lost.

So long as the affection is confined to the membranes of
the lower portion of the cord, a fatal result may be deferred
for some time, and the disease may become chronic ; but,
if it extends upward so as to involve the region from which
the phrenic nerves arise, death very soon takes place by
asphyxia.

So long as the spinal cord remains free from the disease,
the reflex excitability and electro-muscular contractility re-
main unimpaired.

The bladder is not often involved, and the bowels may
be obstinately constipated, or the fecal matters may be
- passed involuntarily.

CHEONIO SPINAL MENINGITIS.

This may arise in consequence of an acute attack, or it
may be developed spontaneously. As in the acute form of
the affection, pain constitutes a prominent feature, and k
situated both in the spinal region and in other parts of the
body. Spasms and contractions of the lower extremities,
and spasms of the muscles of the back, are likewise promi-
nent symptoms.

The pain in the spine is not increased by steady pressure
over the vertebrae, but it is greatly aggravated by every
movement of the body ; for by such motion the nerves are
compressed as they leave the spinal canal, and, as they are
already in a condition of erethism, pressure cannot be borne.

446

DISEASES OF THE SPINAL CORD.

The abnormalities of sensation are usually in the way of
hypersesthesia, which may sometimes be very acute.

The paralysis advances gradually, and rarely, at first,
is very intense in any group of muscles. It is likewise sub-
ject to great variations in the degree of severity. Some-
times the patient finds that he walks tolerably well one day,
while the next he can scarcely move a limb. These difier-
ences depend on the amount of fluid efi:used, which is sub-
ject to changes from day to day.

The bladder is sometimes paralyzed, the sphincter may
be similarly afiected, or this latter may be subject to repeat-
ed attacks of spasm, by which the evacuation of the urine
is prevented.

The bowels, as in the acute form of the disease, may be
either constipated, or the sphincter ani may be so paralyzed
as to allow of the involuntary passage of the fecal matters.

Reflex excitability is rarely lessened, and is often consid-
erably increased. In the case of a gentleman from Ohio
who was recently under ray charge for chronic spinal me-
ningitis, the slightest touch on the sole of the foot was suffi-
cient to cause the limb to be violently drawn up ; and, in
the case of a lady from New Orleans similarly afiected, the •
contact of the bedclothes produced a like efiect.

In several cases I have observed that any mental agita-
tion, or even the attention directed to the affected limbs,
was sufficient to cause violent spasmodic contractions.

Electro-muscular contractility is not generally impaired.

The symptoms are usually aggravated by the recumbent
posture.

Bed-sores are a frequent accompaniment of chronic spi-
nal meningitis.

Causes. — The most common cause of spinal meningitis,
either acute or chronic, is exposure to cold and moisture.
Several cases have come under my charge which clearly
resulted from lying on the cold and damp earth, and from
going to sleep in this situation. In one case which occurred

SPINAL MENINGITIS.

447

in a railway conductor, the train of wliicli lie had charge
was obstructed in its passage by a heavy^ drift of snow.
While workmen were cutting a way through it, he lay down
on a pile of snow, and, being greatly exhausted, soon fell
asleep. Soon after being awakened he had a slight chill
and a mild fever, and the following day experienced severe
pain in the back. This was soon followed by the other
symptoms of spinal meningitis, not very intense in charac-
ter, but persistent, for the affection passed into the chronic
form. Two cases have come under my notice in which the
affection was caused by the back being exposed to a strong
and cold wind.

On account of this influence of cold in producing spinal
meningitis, the disease is far more common in winter than
in summer. Of thirty -nine cases that I have treated wholly
or in part during the last six years, twenty-three occurred
in the months from November to March inclusive.

Exposure to the direct rays of the sun is said to induce
spinal meningitis, but I have never witnessed a case in
which this cause could reasonably be inferred. I may make
the same remarks in regard to the effects of strong muscular
exercise.

It is, however, sometimes a consequence of wounds and
injuries. Seven of the cases under my charge were due to
traumatic causes.

Kheumatism is likewise an occasional cause.

Diagnosis. — The diagnostic phenomena of spinal menin-
gitis, either of the acute or chronic form, are the pain in the
back, increased on any movement of the spinal column ; the
pains in the course of the nerves having their origin from
the diseased region ; the tonic spasms of the muscles of the
back, and of other parts of the body ; the exaltation of reflex
excitability ; and the variations which take place in the ex-
tent and intensity of the paralysis.

Prognosis. — The course of spinal meningitis is generally
progressively onward to a fatal termination — the patient

448

DISEASES OF THE SPINAL CORD.

dying either by the gradual extension of the disease upward
so as to involve more important nerves in the lesion, by the
development of some intercurrent affection, or by exhaustion.
I have, however, seen three cases in which the disease was
arrested, and which will be more specifically referred to
under the head of treatment. And Ollivier,' Brown-Se-
quard,' and Jaccoud,' admit the possibility of cure.

Morbid Anatomy and Pathology. — The lesions found after
death from spinal meningitis may be confined to any one of
the membranes, but more generally are restricted to the pia
mater and the sub-arachnoid space. They consist in thick-
ening of the membrane, spots of opacity, turgidity of the
vessels, and the effusion of a large quantity of spinal fluid.
This fluid is occasionally clear, but is more frequently full
of flocculent matter, or is tinged with blood.

The alterations found in the arachnoid are of similar
character, with the addition that there are numerous hard
cartilaginous plates scattered through the diseased part of
the membrane, which vary in size fi'om that of a grain of
wheat to a mustard-seed.

The dura mater, when it has been the seat of inflamma-
tion, becomes thickened and adherent to the bone. Occa-
sionally it is perforated by the supervention of gangrene, and
the pus collected between it and the vertebrae escapes into
the space between the dura mater and arachnoid, and excites
general meningitis. The theory of the symptoms observed
in spinal meningitis is, that they are due to two immediate
causes, excitation and pressure. The former is the result
of the hyperemia, the latter of the increased amount of spi-
nal fluid causing pressure.

Treatment. — In the acute form of spinal meningitis, active
measures are required. The application of leeches to the
painful part of the spine, or of cups, so as to effect local de-
pletion, will generally prove useful. Hydragogue cathartics

> Trait6 des Maladies de la Moelle fipinifere, etc., Paris, 1827, t. ii., p. 295.
» Op. cit., p. 82. » Op. cit., p. 302.

SPINAL MENINGITIS.

449

are also beneficial, for by their action the vessels of the in-
flamed membranes are depleted of their blood, and the ex-
cessive amount of spinal fluid effused is in consequence
more readily absorbed.

Mercury may also be advantageously administered either
by inunctions with mercurial ointment or by calomel given
internally, or by both these means. Calomel should be given
in doses of from one to two grains every three or four hours,
till the system is brought under its influence, as manifested
by fetor of the breath.

The patient should be kept as quiet as possible, and should
be enjoined not to lie on the back. For the relief of the
dorsal and other pains, suppositories, containing each,half a
grain of codeine, are often efficacious. They may be admin-
istered night and morning.

In the chronic form of the disease, depletion by blood-
letting in any form is not so beneficial as in the acute variety
or as in spinal congestion. Blisters are more admissible,
and scarcely ever fail to do good. They should be applied
on each side of the spinal column near the diseased region
of the cord, and as soon as one heals another should take its
place. The actual cautery I have never used, nor have I
ever seen such good results from its employment as from the
action of blisters. Purgatives are also useful for the same
reasons which prevail in acute spinal meningitis.

Iodide of potassium is always a valuable agent, indeed
more so than any other remedy employed in chronic spinal
meningitis. I employ it in the form of a saturated solution,
which contains about a grain to each drop. Of this, I ad-
minister the first day seven drops three times, preferably
before meals ; the next day eight drops to the dose, the next
nine, and so on, till the patient takes from forty to sixty
drops at the dose, according to circumstances. The iodide
of potassium always acts best when largely diluted with
water, so that, as the doses are increased, an additional
quantity of water should be used.
29

450

DISEASES OF THE SPINAL CORD.

I very often employ the corrosive chloride of mercury in
combination with the iodide of potassium, in doses of the
sixteenth of a grain with each dose of the iodide.

Diuretics may also frequently be given with advantage.
Their object is the same as that which governs in the admin-
istration of purgatives.

In two of the cases cured, to which reference has been
made, I derived the greatest benefit from repeated blisters,
and the persistent use of iodide of potassium. The latter
was carried to the extent of fifty grains three times a day
in one of these cases, and sixty-five in the other.

At the same time the primary galvanic current was ap-
plied to the spine in the manner recommended for spinal
congestion, and the induced current to the paralyzed limbs.
I am very sure that electricity in both these forms should be
used in most cases of chronic spinal meningitis. The fol-
lowing case, reported by J. Frank,* and quoted by Ollivier,"
of acute spinal meningitis, is instructive :

" A captain, aged forty-two years, of sanguineo-bilious
temperament, subject to rheumatic pains and haemorrhoids,
and addicted to the use of alcoholic liquors, was suddenly
seized on the evening of the 2d of March, 1819, with a chill,
which was soon succeeded by a burning fever, accompanied
by pain in the lumbar region. During the night the pain
increased, extended as high up as the occipital region, and
gradually acquired great intensity. J. Frank was called in
the morning at five o'clock, to see the patient, who was suf-
fering acutely. He was uttering loud groans, was lying on
his belly, with the superior and inferior extremities stretched
out to their full length. To the questions put to him, the
patient answered with great difficulty that he had pains all
over his body, that he was unable to open his eyes, that his
teeth were strongly clinched, and that a burning and pulsat-
ing pain extended from the occiput to the lower extremity

* Praxeos Med., etc., de rachialgite, tome vi., p. 76. Turin, 1822.
« Op. cit., p. 295.

SPINAL MENINGITIS.

451

of the vertebral column. The limbs, especially the inferior,
were without sensation, but were agitated by occasional
jerkings. There was such a constriction of the chest that
breathing was scarcely possible, and the abdomen was like-
wise in a state of contraction. There were constipation,
incontinence of urine, a pulse soft but 100 per minute, occa-
sional palpitations of the heart, and a hot and dry skin.

" Frank at once opened a vein in the foot, and abstract-
ed sixteen ounces of blood. A dozen leeches were applied
around the occiput, and as many scarified cups on each side
of the spine. A decoction of tamarinds was given as a
cathartic. These means were sufficient to restore the health
of the patient in a few days. The bloodletting produced
an almost immediate cessation of all the symptoms ; for, a
short time after its employment, the movement of the eye-
lids became easy, as well as that of the jaw ; sensation re-
appeared in the extremities, and the dorsal pain diminished
considerably in intensity."

As Ollivier remarks in regard to this case, several of the
symptoms are those of spinal congestion. The sudden su-
pervention of the disease, as well as its rapid disappearance,
points to that affection. Nevertheless, its general features
are those of acute spinal meningitis — an affection which, of
course, cannot exist without congestion.

In a very interesting case under my charge several
months ago, a cure of the spinal difficulty, which was
chronic spinal meningitis probably of syphilitic origin,
was accomplished by the use of the iodide of potassium
and the corrosive chloride of mercury, as recommended
on pages 449 and 450. In this case the affection had
lasted for several years, and extended from the occiput
to the lower extremity of the spinal cord. The limbs
were constantly subject to violent spasmodic jerkings,
and both legs and one arm were in a permanent state of
contraction, which had existed for three years. Under
the use of the iodide and the mercury, as nientioned, the

452

DISEASES OF THE SPINAL CORD.

pain, wliicli had been intense, ceased, tlie spasms of the
limbs were stopped, the bladder regained its expulsive
power, the bowels again began to act without purgatives or
injections being required, and the limbs could be moved as
extensively as the rigid contractions permitted. These had
existed so long that the flexor muscles had become much
shortened, and the skin in the groins and popliteal spaces
was tense and unyielding. The accompanying woodcut
(Fig. 21) shows the positions of the legs and arm at this
time. Under these circumstances I requested the advice of
my friend Prof. L. A. Say re, and after consultation it was
determined to divide the tendons of the tensor vaginae femo-
ris, the sartorius, the gracilis, and the biceps, on each side.
"When this was done by Prof, Sayre, the patient being under
chloroform, careful but powerful efforts at extension were
made, and the skin in the popliteal space on both sides was
necessarily torn, owing to its contraction and inelasticity;
the limbs were thus brought into a state of complete exten-
sion, and, by a system of weights and pulleys similar to that
used in Buck's fracture apparatus, they were kept in this
position. The patient was, however, too weak to endure
the fatigue of the necessary extension and confinement. He
took off the weights whenever they caused pain or great
uneasiness. To add to the difficulties, a large bed-sore
formed on the right buttock, and the strength of the pa-
tient declined so rapidly that, in order to save his life, the
apparatus had to be entirely removed. He rapidly recov-
ered, but, as cicatrization went on, the limbs again became
contracted, and in the course of two or three months were
as bad as ever. Pain in the back soon afterward super-
vened, the legs and one arm began to be affected with
spasms, and the paralysis also returned. A renewal of the
former medication again caused relief, and the patient has
to this day remained free from any spinal difficulty, though
his legs are still contracted. This is the third case of cure
referred to as happening in my experience.

454

DISEASES OF THE SPINAL CORD.

For the cure of the bed-sores the method recommended
by Dr. Brown-Sequard may be used. It consists in the
alternate application of sponges, one of which is saturated
with hot water and the other with cold water. This should
be done for five or ten minutes every day, and the efiect is
to increase the activity of the circulation of the part, and
to promote the formation of granulations.

But I have generally preferred the method by galvanism
first suggested and employed by Crussel,* of St. Petersburg,
and which I used for the treatment of indolent ulcers with
almost invariable success, in 1859, when surgeon to the Bal-
timore Infirmary. The method was also recommended by
Mr. Spencer Wells." During the last six years I have em-
ployed it to a great extent in the treatment of bed-sores
caused by diseases of the spinal cord, and with scarcely a
failure — indeed, I may say without any failure except in
two cases where deep sinuses had formed which could not
be reached by the apparatus.

A thin silver plate, no thicker than a sheet of paper, is
cut to the exact size and shape of the bed-sore. A zinc
plate of about the same size is connected with the silver
plate by a fine silver or copper wire six or eight inches in
length. The silver plate is then placed in immediate con-
tact with the bed-sore, and the zinc plate on some part of
the skin above — a piece of chamois-skin, soaked in vinegar,
intervening. This must be kept moist, or there is little or
no action of the battery. Within a few hours the efiect is
perceptible, and in a day or two the cure is complete in the
great majority of cases. In a few instances a longer time is
required. I have frequently seen bed-sores three or four
inches in diameter, and half an inch deep, heal entirely over
in forty-eight hours. Mr. Spencer Wells states that he has

1 Neue Med.-Chirurg. Zeitung, No. 1, 1847, p. 235.

2 Lectures on Electricity and Galvanism, by Dr. GoldingBird, London, 1849,
appendix. There is an American edition of this very interesting little book,
but it has long been out of print.

SPINAL MENINGITIS.

455

often witnessed large ulcers covered with granulations with-
in twenty-four hours, and completely filled up and cicatriza-
tion begun in forty-eight hours. During his recent visit to
this country I informed him of my experience, and he re-
iterated his opinion that it was the best of all methods for
treating ulcers of indolent character and bed-sores.

Ergot is not so generally useful as in congestion, though
I rarely fail to give it at some time or other in cases of
chronic meningitis, with a view to the relief of the ac-
companying congestion. Strychnia is not at all admissible
at any time. Reeves* recommends it in those cases in
which pains, cramps, and contractions, are absent, but I
have never seen such cases. Indeed, a case in which they
were not prominent symptoms could scarcely be regarded as
one of spinal meningitis.

' Diseases of the Spinal Cord and its Membranes, and the Various Forms of
Paralysis arising therefrom. London, 1858, p. 65.

CHAPTER Y.

ACUTE MYELITIS.

Acute inflammation of the substance of the sj)inal cord
is not a very common affection, but it is so essentially dis-
tinct in its symptoms and results from chronic myelitis that
it requires separate consideration.

Symptoms. — A chill is generally the first symptom ob-
served, and this is followed immediately by high febrile
excitement, during which the pulse often reaches a rapidity
of 160 per minute. Alterations of sensibility and motility
are noticed with the inception of the fever.

Among the first, pain in the back, at the seat of the
lesion, is prominent. It is aggravated by percussion, and
by the passage of a sponge saturated with hot water, or one
with cold water, over the affected region. It is not, how-
ever, so intense in character as that attendant on menin-
gitis.

The limbs below the seat of the inflammation are like-
wise affected with pains, which are mainly confined to the
trunks of the nerves coming from the affected portion of the
cord.

A pain is also experienced, in the great majority of cases,
at the upper limit of the inflammation, and which extends
around the body at that height. It is generally accom-
panied by a feeling of constriction similar to that which
would be produced by a cord tightly tied around the body.
It is probably caused by spasm of the abdominal or thoracic
muscles.

ACUTE MYELITIS.

457

None of these pains are increased by movements of the
limbs or of the vertebral column, in which respects they
differ from those met with in spinal meningitis.

In addition there are various derangements of the cuta-
neous sensibility in those parts of the skin below the seat
of the disease, and especially in those parts supplied by
nerves originating from the affected segments of the cord.
These consist of formication, " pins and needles," a sensa-
tion as if water were trickling over the skin, as if the limb
were asleep, and of sensations of cold or heat. Anaesthesia
is the most common general condition of the skin, and it is
often accompanied with cutaneous pains, which are the more
intense the more profound is the aneesthesia. Thus, if we
have ascertained that the cutaneous sensibility is very much
impaired at a particular spot, we will frequently find this
spot the seat of severe and spontaneous pains. In such
cases, too, a prick with a pin is felt, but the ability to dis-
tinguish the two points of the sesthesiometer is lost, even
when they are widely separated. Indeed, they may not be
felt at all unless they are so used as to cause pain. I have
several times observed patients whose tactile sensibility was
almost entirely gone, but whose sensibility to pain was so
great that they could not endure the contact of the bed-
clothes. The distinction, therefore, between insensibility
to touch — generally called anaesthesia — and insensibility to
pain — analgesia — must be clearly made.

Hypersesthesia is occasionally present, but probably not
unless there is meningitis associated with the myelitis.

Motility is affected at a very early period of the disease,
and at first consists of simple twitchings of the muscles, and
paralysis. The latter comes on with great rapidity, and
may become complete in a few hours. Jaccoud ' states that
he has seen this result produced in thirty-six hours, and
Ollivier ^ cites several cases to the same effect. The seat of

1 Op. cit, page 318.

' Op. cit., chap, huiti^me, Myelite, ou Inflammation de la Moelle ^pini^re.

458

DISEASES OF THE SPINAL CORD.

the paralysis is in those parts of the body below the diseased
portion of the cord. Thus, if the lower dorsal, or lumbar
region be affected, the lower extremities, the sphincters of
the bladder and rectum, and certain of the abdominal mus-
cles, are involved ; when the difficulty is in the upper dorsal
or cervical region, the upper extremities, and, if the lesion
is high enough, the diaphragm and other muscles of respira-
tion, with those concerned in effecting deglutition, are par-
alyzed. Ocular troubles may also be present in cervico-
dorsal myelitis, from irritation of the sympathetic nerve.
These consist of dilatation of one or both pupils, and of
exophthalmos.

It is not often the case that the homonymous muscles
are equally paralyzed. Thus it is not uncommon to find
one lower extremity entirely deprived of motility, and the
other more or less possessed of its normal amount of power.
The bladder is sometimes paralyzed, and sometimes not, and
the same is true of the vesical and anal sphincters. Ee-
flex power is generally exaggerated in the very first stage,
and greatly diminished or altogether abolished subsequently.
In a few cases I have seen tickling the sole of the foot fail
to excite reflex movements in the lower extremity to which
it belonged, but induce strong movements in the opposite
leg. A similar fact has been observed as regards sensation ;
an impression made upon the skin of one foot, for instance,
not being felt in that foot, but causing pain in the opposite
foot.

Electro-muscular contractility is diminished unless, per-
haps, in the very earliest stage of the affection, and there is
almost invariably a tendency to rapid atrophy of the para-
lyzed muscles. Besides the foregoing symptoms, there are
usually others referable to the viscera, and which differ ac-
cording to the seat of the lesion. Thus, if the inflammation
be seated high up in the cord, the actions of the respiratory
muscles, of those concerned in deglutition, and of the heart,
are affected. There may also be vomiting, derangement of

ACUTE MYELITIS.

459

the liver, of the kidneys, intestines, and generative organs.
The urine is often, if not invariably, alkaline, and there are
frequent, and sometimes constant, painful erections.

The temperature of the paralyzed limbs always falls, and
there is a strong tendency to the formation of sloughs and
bed-sores, which frequently cannot be obviated. I have
seen, in several instances, large sloughs form on each side
of the vertebral column within twenty-four hours of the in-
ception of the attack of acute myelitis.

Acute myelitis ordinarily runs its course in about three
weeks, either, as is generally the case, terminating in death
by asphyxia or exhaustion, or passing into the chronic form
of the disease. It may, however, end fatally in a few days.
In one case under my charge, occurring in a child ten years
of age, and the result of pressure from caries and necrosis
of the vertebrae, death took place in fifty hours. In another,
due to a blow, a fatal termination was reached in forty-five
hours.

Causes. — Acute myelitis is more frequently the result of
injury than of any other cause. It is likewise a sequence
of disease of the vertebraB, extending to the dura mater and
other membranes, and of meningitis. It is also said to be
produced by exposure to extreme heat or cold, by violent
muscular eflforts, and by venereal excesses. Seven cases
have come under my observation. Of these, three were the
result" of wounds, two ensued on disease of the vertebrae, and
two were caused by extension of acute meningitis.

Diagnosis. — The principal diagnostic marks of acute
myelitis are the occurrence of the sensation of constriction
around the body, the alkalinity of the urine, the rapid super-
vention of the paralysis, the great predisposition to sloughs
wherever there is the least pressure, the excitation of pain
in one part of the body by irritation applied to some other
part, the causation of reflex movements in a similar way,
and the marked depression of temperature in the paralyzed
parts.

460

DISEASES OF THE SPINAL CORD.

The absence of the characteristic symptoms of congestion
and of meningitis will suffice likewise to separate it from
these affections.

Prognosis. — The termination of acute myelitis is in death
sooner or later. Even if it passes into the chronic stage, the
alterations in the structure of the cord are so extensive as
to be incompatible with the performance of its functions.
Death was the result in all the cases that I have person-
ally observed, and this event occurred in all within three
weeks.

Morbid Anatomy and Pathology. — The morbid action in
cases of acute myelitis may be limited to the white substance
or to the gray substance, or may attack both these tissues.
It may likewise affect the • antero-lateral columns, the poste-
rior, or extend to both. Undoubtedly, if we had sufficient
opportunities to witness cases of spontaneous origin not the
result of traumatic causes, or of the extension of other dis-
eases, we should be enabled to distinguish by the symptoms
which part of the cord histologically or topographically is
affected. For there can be no doubt that, as in anaemia, or
as we shall see hereafter in the chronic form of myelitis, the
symptoms must be as characteristic as are the functions of
the several histological and regional parts of the cord.

As regards the obvious morbid anatomical features, we
find that when the lesion is situated in the white substance
the membranes of the affected portion are congested, thick-
ened, opaque in patches, and adherent to the cord. The
cord is softened to a variable depth, and this portion is
detached with the membranes if these be removed. This
softened portion is in the early stage rose-colored and stud-
ded with red points, marking the situation of the enlarged
blood-vessels. As the disease advances, the color deepens
to a reddish brown, then begins to get lighter, and, pass-
ing through several shades of yellow, eventually becomes
white,

AYhen the gray substance is involved, the changes in its

ACUTE MYELITIS.

461

physical appearance are similar ; and, when both the white
and the gray are the seat of the morbid process, it is
impossible to distinguish the two substances from each
other.

Microscopical examination shows the existence of con-
gestion, and, as an essential feature, an increase in the
amount of connective tissue or neuroglia of the cord. The
evidences of this hypertrophy are seen in the increase of
fusiform cells and in the production of multinuclear cells and
free nuclei. These formations take place at the expense of
the proper nervous tissue of the cord, the anatomical ele-
ments of which undergo atrophy and fatty degeneration.
The nervous tubules are thus often disintegrated and their
contents disseminated through the extraneous tissue. The
axis cylinders are entirely surrounded by oil-globules, or
are altogether broken up and rendered unrecognizable.

Should suppuration occur, the elements of pus are ob-
served among those already described, and take their place
to a considerable extent.

In case of the passage of acute myelitis into the chronic
form, the centre of inflammation usually undergoes other
changes, which, however, still maintain the general charac-
teristic of hypertrophy of the neuroglia at the expense of the
proper nervous tissue. Induration, or, as it is now generally
called, sclerosis, is the result. Occasionally, however, the
softening persists and becomes the permanent structural
condition of the diseased portion of the cord.

"When the lesion is in the gray substance, the microscope
shows the nervous cells to be broken up, and the anatomical
elements of the blood to be scattered through the tissue.

Treatment. — The treatment of acute myelitis offers no
encouraging features. The most that can be done is to
endeavor to prevent, as far as possible, the formation of
sloughs, by placing the patient on a water-bed, and by
sponging the parts exposed to pressure,with whiskey or with
hot and cold water alternately applied. The treatment gen-

462

DISEASES OF THE SPINAL CORD.

erally does not differ from that recommended in acute men-
ingitis, the indications being almost identical. So far as
my experience extends I have never found any means suffi-
cient for cure, and the few successful instances that have
been reported are doubtless, as Jaccoud suggests, cases of
congestion or meningitis.

CIIAPTEE YI.

SPINAL SOFTENING.

Softening of the spinal cord is, as we have seen, the com-
mon termination of acute myelitis, in which connection it
has been sufficiently considered ; but it may originate pri-
marily, and in that event possesses a clinical history very
distinct from that of acute inflammatory softening.

Symptoms. — The first symptom usually noticed in soften-
ing of the spinal cord is numbness in those parts of the body
below the seat of the lesion. Soon after the occurrence of
this symptom there is weakness of the same parts, and then
the deficiency of sensation and the feebleness of motor power
advance together, both gradually becoming more and more
strongly marked. There are no muscular twitchings, no
contractions of the limbs, no pains either at the seat of the
disease or in the paralyzed limbs.

The bladder very soon becomes involved, and the patient
finds that, when he attempts to urinate, the stream is not so
strong as it once was, and that he is obliged at times to use
the expulsive force of the abdominal muscles in order to
complete the evacuation of the bladder. Gradually the con-
tractile power of this viscus becomes less, and finally is alto-
gether lost.

The sphincter generally participates. The desire to
urinate becomes more frequent, and when the inclination is
felt the patient must at once yield to it. Eventually the
bladder likewise becomes entirely paralyzed, and then there

464

DISEASES OF THE SPINAL CORD.

is neither the ability to expel the urine nor to retain it, and
consequently it dribbles away constantly.

Sometimes the first evidence of softening of the cord is
perceived either in the bladder or its sphincter, and it may
be restricted to these parts for a considerable period. I
have a patient at the present time (February 9, 1871) under
treatment for what I have no doubt is softening of the cord,
and in whom the bladder-troubles were the only notable
symptoms for over two years.

The intestines are similarly affected, and the bowels are
either obstinately constipated or the sphincter ani is relaxed,
leading to fecal evacuations as soon as the contents reach
the rectum.

Reflex excitability is weakened from the first, and gradu-
ally disappears, unless, as is rarely the case, the gray matter
be unaffected.

The progressive advance of the disease reduces the pa-
tient to a condition of utter helplessness. He is unable to
walk, sensation is abolished in the paralyzed limbs, his urine
and faeces are passed involuntarily, bed-sores occur, the vene-
real appetite is extinct, or, if it should remain, erections are
impossible, and the parts of the body below the seat of the
disease are to all intents and purposes cut off from commu-
nication with the parts above. This condition may last for
years without a fatal termination ensuing, but intercurrent
affections, especially resulting from the bladder-difliculties,
may eventually cause death.

Such is the course of spinal softening when the lesion is
low down and involves both antero-lateral and posterior col-
umns. When it is higher up, the symptoms are also refer-
able to the thoracic extremities, and to the muscles con-
cerned in deglutition and respiration. There are likewise
visceral disturbances.

"When the lesion mainly affects, or is confined to the
antero-lateral columns, the symptoms manifested are in inti-
mate relation with the known physiological functions of the

SPINAL SOFTENING.

465

region in question. Thus the power of motion in the limbs
below the softened portion of the cord gradually becomes
less, the gait is from the first staggering, and though even at
a late stage the patient may be able to move his limbs while
lying down or sitting, he cannot support the weight of his
body upon them. When he tries to stand without extrane-
ous aid, it is seen that he is especially weak in the knees
and ankles. There is no more difficulty in standing or walk-
ing with the eyes shut than when they are open.

This paralysis of motion, in which the bladder generally
participates, may be of the most profound degree, and yet
sensibility be perfect. A gentleman was under my care in
whom I diagnosticated softening of the cord in that part
extending on the right side from the second dorsal vertebra
downwavd probably as far as the fourth sacral, while on the
left side it began at about the fourth lumbar and extended
downward probably as low as the fourth sacral. I gave the
lesion these topographical limits for the reason that on the
right side the muscles supplied by the crural and sciatic
nerves had lost their electro-muscular contractility, while it
certainly did not extend above the origin of the ilio-hypo-
gastric nerve, as the lower part of the rectus abdominis,
which receives its motor power through this nerve, retained
its contractile power. On tlie left side the muscles supj)lied
by the crural were possessed of their normal motor power,
while those supplied by the sciatic had lost their contractility.
It was, therefore, very certain that on this side the lesion
did not extend above the fourth lumbar, the lowest spinal
nerve contributing to the formation of the crural.

I was able also to restrict the morbid process entirely to
the antero-lateral columns, for in no part of the skin below
the upper supposed limit of the lesion was there any loss of
sensibility. The least impression made upon the skin was
felt. Tickling the sole of the foot excited laughter, but no
reflex movements. I was therefore able to determine that
the gray matter was involved. The bladder was paralyzed,
30

466

DISEASES OF THE SPINAL CORD.

and its sphincter likewise. The sphincter ani was also de-
prived of its contractile power to a great extent.

The patient died at Cape May, and I had no opportunity
of making a post-mortem examination. There can be no
doubt, however, that the lesion was essentially that which I
have described. In all cases of spinal softening involving
the antero-lateral columns, the electro-muscular contractility
is soon lost, so that even the strongest induced or primary
currents fail to cause contractions.

As regards the implication of the posterior columns,
there is an equal facility for determining the fact from a
consideration of the symptoms. The functions of these col-
umns are intimately connected with sensation, and when
such a morbid process as softening is set up in them the
symptoms are those which indicate impairment of the cuta-
neous and muscular sensibility. Thus, in a gentleman now
under my charge, there has been going on for several
months a morbid action in the spinal cord unattended by
any prominent symptoms except anaesthesia. There has
never been pain or any derangement of motility, but simply
a gradually-increasing loss of sensibility in both lower ex-
tremities and in all the other parts of the body below the
upper limit of the seat of the lesion.

He is unable to walk in the dark or with his eyes shut,
or to stand alone with his eyes closed and his feet close
together, for he obtains no idea of his position unless he can
have the aid of his eyes or hands.

He has full power over the bladder and voluntary con-
trol over its sphincter and that of the rectum, but he never
experiences the desire to urinate, does not feel the flow of
urine through the urethra, nor the passage of the fseces
through the anus, and evacuates his bladder and bowels at
stated periods merely from the knowledge acquired by ex-
perience that it is tiine to do so.

Examination with the aesthesiometer shows that the up-
per limit of the lesion on both sides is in that part of the

SPINAL SOFTENING.

467

cord from which the second lumbar nerves are derived, for
the loss of sensibility is apparent in all those parts supplied
by the crural and sciatic nerves, both as regards the skin
and the muscles. Yery weak faradaic currents cause mus-
cular contractions, but the strongest which it is possible to
obtain from a powerful machine produce no pain.

In this case there is, I think, ample reason to diagnosti-
cate a lesion of the posterior columns without any implication
of the antero-lateral. The reasons for believing this lesion
to be softening will be indicated under the head of diagnosis.

Causes. — The causes of spinal softening are not very
clearly understood. Doubtless it arises as a consequence
of acute myelitis, but it is often an independent and appar-
ently a primary affection, being unpreceded by any obvious
symptoms indicative of spinal derangement. Such influ-
ences as give rise to cerebral softening will, in all probabil-
ity, cause spinal softening, and among them must be placed
obliteration of blood-vessels from embolism and thrombosis.
The actual occurrence of occlusion of spinal vessels from
either of these causes has not, however, so far as I am
aware, been demonstrated. The further etiology of spinal
softening is not as yet a matter of any certainty, though I
think several cases that have been under my observation
could reasonably have their cause laid to excessive sexual
indulgence.

Diagnosis. — The diagnostic marks of most value in cases
of supposed spinal softening are the absence of sensory and
motor excitement. Thus there are no pains referable to the
back or other parts of the body, no hyperaesthesia, no twitch-
ings, no spasms, no contractions, no exalted reflex actions.
And this is the case in that form of the disease involving
the whole thickness of the cord, or in either of those limit-
ed to the anterior or posterior columns. There is no other
afiection of the spinal cord which is not characterized, at
some time or other of its progress, by irritation either of the
sensory or motor nerves, or of both, excepting some cases

468

DISEASES OF THE SPINAL CORD.

of spinal anaemia giving rise to the categories of symptoms
previously considered. The clinical history of such cases,
and the comparatively light character of the phenomena,
will serve to distinguish them from those in which the lesion
is softening.

Prognosis. — The prognosis is always unfavorable as re-
gards recovery and complete restoration, but spinal soften-
ing is not necessarily a fatal disease. At least I have seen
cases which had existed for many years, and which appar-
ently had no elements of a fatal termination about them.
But they were instances in which the seat of the disease
was in the lower dorsal, or lumbar or sacral region of tlie
cord. When it is higher up, the prospect of death ensuing
is more probable. The restoration of the cord to its normal
structure is impossible, and the patient lies paralyzed either
in sensation or motion, or both, according to the situation
and extent of the lesion, in a condition similar to that of a
person who has received a wound inflicting irreparable in-
jury on the cord. Such persons, as is well known, fre-
quently live for many years afterward — then die of some
entirely different disease. There is nothing about spinal
softening calculated to produce exhaustion, unless it be the
tendency which exists to cystitis from paralysis of the blad-
der, and the consequent inflammation liable to be set up
from the action of the retained urine. Care, however, will
very greatly diminish the danger from this source, I have
had a number of patients under my charge who had not,
for many years, had a passage of urine from the bladder
which was not effected with the catheter, and they had, in
all that time, suffered no marked inconvenience.

Morbid Anatomy and Pathology. — The appearance of a
softened portion of the spinal cord to the naked eye has
nothing very peculiar about it. When examined as to its
consistence, it is seen to be sometimes as soft as cream, at
others scarcely altered in the resistance which it offers to
the touch. In the first instance, when the lesion involves

SPINAL SOFTENING.

4G9

the gray and wliite matter together, section does not show
the peculiar double cresentic arrangement of the former tis-
sue, but it appears to be blended homogeneously with the
white substance which surrounds it.

Microscopically it is seen that the nervous tubules con-
stituting the essential anatomical elements of the white sub-
stance are broken up, and no vestige of them remaining in
extreme cases — oil-globules and bodies called granule-mass-
es, the constituent of which is fat, having taken their place.
In the gray substance the nervous cells are destroyed, and
oil and fat have made their appearance in large amount.
Even the neuroglia or connective tissue of the cord exhib-
its a similar disintegration and regressive metamorphosis.
These changes impair the functions of the cord, both as a
nervous centre and as a structure serving for the transmis-
sion of sensory impressions to the brain, and of nervous
force from it. When the disintegration is complete, the
effect is the same as if the cord had been entirely divided
by a cutting instrument.

Treatment. — There is nothing to be done which can by
any possibility restore the integrity of the spinal cord after
the process of softening has fairly entered upon its course.
In the very early stages, if patients apply for treatment at
these times, something may perhaps be accomplished by
the use of phosphorus and strychnia, but the symptoms
come on so insidiousl}'' and gradually that the subject of
them rarely has his apprehensions excited till it is too late
to do any thing toward arresting the disease. And even
when we do see cases which in appearance exhibit the symp-
toms met with in spinal softening in its initial stage, and
which recover under treatment, there must always be a
doubt in regard to the accuracy of the diagnosis — for many
cases of temporary anaesthesia and impairment of motility
are due to anaemia of the cord, the result of the causes set
forth in a previous chapter.

The patient, however, may be made comfortable to such

470

DISEASES OF THE SPINAL CORD.

an extent as to materially prolong his life. Care should to
this end be taken that he does not sustain a fall or suffer an
injury whereby the diffluent portion of the cord would be
disturbed in its anatomical relations, and the danger of an
attack of acute meningitis or of myelitis incurred. Bed-
sores should be prevented, or, if they occur, treated accord-
ing to the methods previously mentioned, and full instruc-
tions should be given in regard to emptying the bladder
with the catheter at regular times, and of going to stool
at the same hour every day. Locomotion may be provided
for by some one of the chairs devised for the use of para-
plegics.

CHAPTER YII.

SCLEROSIS OF THE ANTE RO-L ATE RAL COLUMNS OF THE
SPINAL CORD.

Sclerosis affecting the antero-lateral columns of the spi-
nal cord, whether it be diffused, multiple, or cortical, gives
rise to symptoms which do not vary essentially with the
form. It will therefore be advisable to consider them all
under the present head, pointing out in the course of the
description such distinctions as can be shown to exist.

Symptoms. — In cases of sclerosis limited to the antero-
lateral columns, there are no aberrations of sensibility either
in excess or diminution, but as it very generally happens
that there is more or less meningitis, pain may be experi-
enced, or there may be different degrees of anaesthesia from
the posterior roots of the spinal nerves being implicated.
From the same cause acting on the anterior roots, twitch-
ings and jerkings of the muscles and limbs below the seat
of the lesion will be produced. The existence of pain, or
of muscular contractions, in the early period of the disease
is, therefore, always indicative of the fact that the mem-
branes are involved in the morbid process.

So far as the cord itself is concerned, the first symptom
is loss of muscular power. At first the patient merely tires
more readily, slight exertion fatigues him, and this is espe-
cially noticed in the muscles which flex the leg on the thigh,
and the consequent sensation of weariness experienced in the
popliteal space. Sometimes it is shown in the sudden relax-
ation of the extensor muscles of the leg, and the fall of the

472

DISEASES OF THE SPINAL CORD.

patient thereby ; at otliers, in tlie fact that the extensors of
the foot become weak, allowing the toes to drop, and hence
causing stumbling. The gait then becomes characteristic.
Owing to the fact that the patient's extensor muscles are
weak, he is unable to lift the feet high enough to cause them
to clear the ground, and hence he throws them out by means
of the abductor muscles of the thigh, and thus causes them
to describe an arc of a circle. Then in putting them down
the heel strikes the ground a longer time before the sole
than it does in the natural gait, and hence the foot comes
down with a jerking motion. This is the ordinary manner
of walking practised by a person affected with the disease
under notice. In another form of locomotion, the body is
moved laterally on the thighs, first to one side and then to
the other, in such a way as to cause the feet to be raised
high enough without the complete action of the extensor
muscles. The gait is therefore similar to that of a duck, or
of a woman with a very wide pelvis. In a patient now in
the New York State Hospital for Diseases of the Nervous
System, this method of progression is very strongly marked.
The motion of the body is almost serpentine, and the feet
glide over the ground barely lifted high enough to avoid
contact.

In both the methods of walking the patient requires sup-
port. At first a cane answers, then he comes to crutches,
and eventually the assistance of an attendant becomes ne-
cessary.

As a consequence of the paralysis, the movements are
often complicated and sometimes rendered impossible by the
legs becoming interlocked at every attempt to walk. In a
patient from Connecticut under my care, not long since, this
difiiculty was a very prominent feature, and though the
muscles of flexion and extension were sufficiently strong to
allow of his walking, those which abduct the thighs were so
materially paralyzed as to produce the condition mentioned.

Keflex movements, so far from being lessened, are gener-

ANTERO-LATERAL SPINAL SCLEROSIS.

473

ally exalted, and this for the reason that sclerosis rarely
affects to much extent tlie gray matter of the cord. Some-
times this exaltation is so notable a feature as to cause great
inconvenience. A gentleman now under my charge, with
sclerosis of the antero-lateral columns, has no contractions of
the limbs or even twitchings of the muscles, unless through
the influence of an irritation applied to them. He has no
voluntary power whatever over the lower extremities, and
yet the slightest touch on the sole of the foot or side of the
ankle is sufficient to cause powerful reflex movements in
either leg. In another, in which the disease is not confined
to the anterior columns, but which likewise extends to the
posterior, the mere contact of a straw with the sole of the
foot — an irritation not felt, for there is plantar an£esthesia
— causes contractions to such a degree as to flex both the leg
and the thigh to the utmost possible extent.

The electro-muscular contractility is also usually in-
creased. Under the influence of mild induced currents,
every individual muscular fasiculus can be seen to contract,
and, as the layer of fat under the skin is generally absorbed
at an early period of the disease, the bundles of fibres can
be very distinctly made out.

But, although in the early stages of the disease there are
no muscular contractions unless there is irritation of the an-
terior roots of the spinal nerves coming from the affected
portion of the cord, at a late period there may be involun-
tary movements, due entirely to the sclerosis. These are
the result of the implication of the fibres of origin of the
nerves in the morbid process, and consist of fibrillary contrac-
tions, twitchings of whole muscles, or jerkings of the limbs.
They are manifested without being set into action by vol-
untary movements, and therefore differ from the twitchings
observed in cases of cerebro-spinal sclerosis, and which are
due to the association of the pons Varolii or other cerebral
ganglia in the disease. Tremor is, therefore, never observed
in spinal sclerosis of any form, diffused, multiple, or cortical,

474

DISEASES OF THE SPINAL CORD.

unless the pons Varolii or superior ganglia of the brain are
implicated. In the onlj case of this latter form published
— that of Yulpian * — the sclerosis extended throughout the
whole length of the cord, and likewise involved the pons
Yarolii, cerebellar, peduncles, and other intracranial organs,
besides being accompanied by well-marked spiual menin-
gitis. The tremor observed at a late period of the disease
cannot, therefore, be ascribed to the lesion of the cord below
the medulla oblongata.

The relations of tremor to the other forms of spinal
sclerosis will be further considered under the head of pathol-

Anotlier symptom, indicating the extension of the mor-
bid action to the origins of the nerves, is atrophy of the mus-
cles deriving their nervous influence from nerves originating
at the diseased portions of the cord. In the cortical form of
the disease, we should not expect this symptom to be pres-
ent, for the lesion afiects only the superficial layer of white
substance, nor is it for the same reason apt to exist in cases
of multiple sclerosis of the antero-lateral columns. It is —
and the same may be said of muscular contractions — almost
peculiar to the diffused form of the affection.

The bladder is often paralyzed, and hence the patient is
obliged to use the catheter for the evacuation of the urine.
The sphincter becomes involved at a later period.

But it frequently happens that the bladder and sphincter
both escape. A number of such cases have been under my
charge, and in one still being treated, which has lasted sev-
eral years, and in which both lower extremities are entirely
paralyzed, the bladder and sphincter retain full power. In
those cases in which they are not implicated, the morbid
action does not penetrate deep enough to involve the origins
of the nerves.

The bowels are usually obstinately constipated at first,

' Note sur un cas de Meningite spinale et de Sclerose corticale annulaire de
la Moelle Epiniere, Archives de Physiologie, No. 2, 1S69, p. 279.

ANTERO-LATERAL SPINAL SCLEROSIS.

and throughout the whole course of the disease till toward
the close, when incontinence from paralysis of the sphincter
ani takes place.

Sclerosis of the antero-lateral columns of the spinal cord
is not a rapid affection, although its course is ordinarily
progressively onward. Occasionally there are well-marked
symptoms, and it often happens that medication produces,
for a while, favorable results. The duration of the disease
is from about two to five years. Cases have been reported
in which death ensued within a few months, and I have
a case now under my notice in which it has lasted twelve
years, and in which, even now, the patient can walk tolera-
bly well. Death takes place either from the extension of
the morbid action, or from some intercurrent affection.

The symptoms, of course, vary with the position of the
lesion. When the upper region of the spinal cord is affect-
ed, the superior extremities, and the parts of the body sup-
plied with nerves from the diseased portion of the cord, par-
ticipate. In a case which I first saw in consultation with
my friend Dr. Walter F. Atlee, of Philadelphia, and which
was subsequently for a long time under my immediate
charge, the lesion was, in the beginning, confined to the
very lowest part of the spinal cord. Gradually the disease
extended upward, or new centres of sclerosis were formed,
until at last, after three years, the muscles of deglutition
and of respiration became implicated, and death took place.
But for several months before this the patient was unable
to use either legs or arms, or even to sit up. At no time,
however, was the bladder -deranged in any respect, and at
no time were there pains or spasmodic action of the muscles.
The cutaneous sensibility was scarcely affected, and there
was no atrophy beyond that due to long-continued inaction
of the muscles. ISTo post-mortem examination was made,
but there can be little if any doubt that the lesion was com-
paratively superficial, and that it was almost entirely con-
fined to the antero-lateral columns of the cord.

DISEASES OF THE SPINAL CORD.

In a similar case occurring in a distinguislied legal gen-
tleman of New Orleans, sent to me . by my friend Dr. Cabell,
of the University of Virginia, there is a gradual extension
of the disease upward without any attendant pains, anaes-
thesia, or muscular contractions, except to a slight extent at
first. In this instance, also, the bladder and rectum have
escaped. That the lesion is superficial, and confined to the
antero-lateral columns, I am very sure.

In another case, that of a gentleman from 'New Jersey,
there is a similar condition, but with the additional phe-
nomenon of muscular atrophy.

Such cases as the foregoing, and several others which
have come under my notice, are doubtless to be classed with
many of those placed under the head of what Duchenne '
has called general spinal paralysis — while others have been
referred to softening of the antero-lateral columns of the
cord.

Causes. — Although sclerosis of the antero-lateral columns
of the spinal cord may be due to an antecedent attack of
acute myelitis, or one of meningitis, there is no doubt it is
often a primary disease.

Sex is certainly a predisposing cause ; probably, how-
ever, acting secondarily, from the fact that difference of sex
almost necessarily implies difference in mode of life. Males
are much more liable to the disease than females. Of the
forty-eight cases that have been under my care, or in which
I have been consulted during the past six years, forty-two
were males.

Age is also influential. Of the forty-eight cases, all
were over the age of twenty -five, and none were over
sixty. One was over fifty -five, three between fifty and
fifty-five, seven between forty-five and fifty, and all the
rest under forty-five, when the disease first manifested it-
self.

* Paralysie gdndrale spinale. De I'Electrisation localisde, etc. Paris, 1861,
p. 268.

ANTERO-LATERAL SPINAL SCLEROSIS.

477

Hereditary influence is undoubted in many cases; so
far, certainly, as it is exerted by the ancestors having suf-
fered from some form of nervous disease. In other instances
there is the transmission of a direct tendency to the disease
in question by some no very distant ancestor having had the
same atfection.

Among the exciting causes are the excessive use of alco-
holic liquors, inordinate sexual indulgence, exposure to se-
vere cold, blows on the spine, and the gouty, scrofulous, or
syphilitic diathesis. In the great majority of cases the
cause is not apparent.

Diagnosis. — There is rarely much difficulty in recognizing
sclerosis of the antero-lateral columns of the cord ; for, as
will have been perceived, the symptoms are well marked.
The only affection with which it is really liable to be con-
founded is softening of the same region ; and here the fact
that sclerosis is almost always accompanied by meningitis,
and that therefore there is in the first stage evidence of
sensory and motor excitation, will generally suffi(;e to ren-
der the diagnosis accurate. The gait of a person affected
with sclerosis is, moreover, very different from that of one
suffering from softening ; the course of the disease is slower,
and the paralysis rarely so profound. Other diagnostic
marks will be perceived from a consideration of the symp-
toms of the two forms of chronic myelitis as I have described
them.

Prognosis. — The prognosis is alwaj^s grave ; and, sooner
or later, a fatal termination usually takes place. Still,
great ameliorations are possible, and a cure is not im-
possible.

Morbid Anatomy and Pathology. — The essential feature of
sclerosis occurring in the spinal cord is identical with that
of the same condition affecting the cerebral hemispheres, and
which has already been considered. It consists of hyper-
trophy of the connective tissue and atrophy of the proper
nerve-substance. A part of the cord which has undergone

478

DISEASES OF THE SPINAL CORD,

this change presents features which are easily recognizable.
Its color is changed to a yellowish gray, and its consistence
is much increased. At the same time there is a decided
condensation, so that the circumference of the cord is les-
sened. As already stated, sclerosis appears in the spinal
cord under three forms. In one of these, called diffused
sclerosis — the sclerose uniforme of Jaccoud — the lesion oc-
cupies a considerable extent of the tissue, and may involve
the whole thickness of the cord throughout its entire
length. In another multiple or disseminated sclerosis — the
sclerose en jplaqiies disseminees of Charcot and the sclerose
diffuse of Jaccoud — the lesions are several in number and
are entirely isolated. In the third, cortical sclerosis — the
sclerose corticale annulaire of Yulpian — the lesion is
confined to the superficial layers of the cord. In which-
ever of these forms the lesions exist, they are marked by
white striae, which are the proper nerve-filaments, still
presenting somewhat their characteristic color and consist-
ence.

The membranes often exhibit evidences of inflammation,
and are thickened, opaque in spots, or red in some cases,
while in others they are adherent to each other and to the
cord.

When submitted to microscopical examination, the scle-
rosed tissue is seen to consist mainly of an excessive amount
of connective tissue — the neuroglia of Yirchow. The cells
are increased in size, and the nuclei are larger and much
more numerous than in the normal condition. The capil-
laries are thickened, from the deposition on their walls oi
several layers of rounded cells.

The effect of this morbid process is to compress the
nervous filaments and to cause their atrophy. The fluid
portion undergoes fatty degeneration, and the axis cylinders
become disintegrated.

In a case of sclerosis of the antero-lateral columns of the
spinal cord, which was for a time under my care, I have

ANTERO-LATERAL SPINAL SCLEROSIS.

479

recently had the opportunity of making a careful examina-
tion of the diseased portions.

The patient, J. H., consulted me in the winter of
1869-70. He was then unable to walk without a cane and
the assistance of an attendant. He had previously been
treated at a water-cure establishment, and more recently by
the Swedish movement-cure, and of course without benefit.
The symptoms were mainly connected with motility. Both
lower extremities were paralyzed ; the bladder was inactive,
but not the sphincter, and there was obstinate constipation.
There were occasional fibrillary contractions of the para-
lyzed muscles, and at times pain in the back and limbs —
never, however, of any great degree of severity. There
were no tremors, either with or without voluntary motions.

The patient obtained very little benefit from the treat-
ment to which I subjected him, and I advised him to return
to his home in Ohio. A few months afterward, he died.

The dorsal, lumbar, and sacral regions of the cord
were sent to me for examination by his physicians, Drs.
Eamsey and Bishop, of Delhi, Ohio. In a letter, the latter
informed me that the vessels of the pia mater were injected.

The cord arrived in good condition, having been care-
fully preserved in strong alcohol. Upon inspection, the
antero-lateral columns in the middle and lower dorsal regions
to the extent of three and a half inches were seen to be of
a grayish tint, which became deeper in shade from above
downward. Below this, at the junction of the dorsal with
the lumbar portion, was another patch two and a half inches
in length, and also involving the whole superficies of the
antero-lateral columns ; and, separated from this by a por-
tion of apparently healthy tissue, was another discolored,
irregular patch, an inch and a half in length, along the left
antero-lateral column ; and, below this, a similar tract, two
inches and an eighth long, involving the right antero-lateral
column. The difference in consistence between these
patches and the other parts of the cord was very decided,

480

DISEASES OF THE SPINAL CORD.

and the white strise were well marked. The sacral portion
of the cord presented no abnormal appearance to the
naked eye.

Sections of the cord were then made through the scle-
rosed portions ; and it was seen that the gray matter was
only involved where the horns approached the surface; and
that, wherever a lesion existed, the normal contour of the
sections was altered so as to make them sub-ovoidal, and
thus to lessen the circumference. The greatest depth of any
part of a sclerosed region was two-twelfths of an inch, and
this was in the superior patch. The average thickness was
about the one-twelfth of an inch.

The whole cord in my possession was then immersed in
a solution of chromic acid in water, and left there for a
month to harden. Immediately previous to examining
with the microscope, the sections were colored by an
ammoniacal solution of carmine. Under a twelfth-inch
objective, it was seen that, throughout the whole extent of
the sclerosed portion of any section, the nerve-tubes had
entirely disappeared; and, wherever the gray substance
was aifected, the nerve-cells were diminished in number.
In the place of these elements was connective tissue, a large
quantity of molecules, and coimective-tissue cells in great
abundance.

In several sections taken from the dorsal, lumbar, and
sacral regions, and which were apparently normal when
viewed with the naked eye, the neuroglia was found
to be in excess, and the nerve-tubes in a state of disinte-
gration.

The gray matter, except in those sections made through
the part where the sclerosed portion extended from the white
matter to it, was uniformly healthy, and in no part were the
posterior columns involved.

In this case there was no tremor, although it was clearly
one of multiple sclerosis, probably entirely confined to the
spinal cord. At no time had there been head-symptoms of

4NTER0-LATERAL SriNAL SCLEROSIS.

481

any kind. I tliink, tlierefore, that Br. M. Clymer ' is in
error, where lie states, under the head of "Disseminated
Sclerosis of the Spinal Form," that "rhythmical spasms
accompany any voluntary movement of the affected muscles."
As previously stated, I am of opinion that such movements
are only present when the affection has also attacked the
central ganglia — and, indeed, the cases cited by Dr. Clymer,
in the appendix to his excellent memoir, abundantly sustain
this ^new ; for, of the sixteen cases tabulated by him, tremor
is not stated to have occurred in any one in which the lesion
was limited to the cord.

In the case of Dr. Pennock, reported by Drs. Morris and
S. Weir Mitchell,' the sclerosed tissue was confined to the
spinal cord and mainly to the lateral part of the antero-lat-
eral columns. The posterior were involved to a very small
extent. In this case there were partial anaesthesia, gradu-
ally advancing paralysis implicating all four extremities,
and paralysis of the bladder. The intellectual faculties
were never affected in the least. The course of the disease
was progressively onward, and, though there was toward the
last a total loss of voluntary power below the neck, reflex
action remained unaffected. There were no tremors with
or without voluntary movements. In regard to this case.
Dr. Mitchell, who made the microscopical examination, re-
marks that there were :

" 1. Integrity of mental and moral manifestations.

2. Absolute loss of voluntary motive power below the
head, or rather below the neck.

3. Sensation nearly perfect.

4. Respiration good ; reflex motion preserved and ex-
hibited in the form of spasm or irritation of certain parts of
the skin."

All of which are what we should expect to find in scle-
rosis almost entirely confined to the antero-lateral columns.
In the description of the disease as given by several au-

' Op. cit., p. 12. 2 American Journal of the Medical Sciences, July, 1868.
31

482

DISEASES or THE SPINAL CORD.

thors, great stress is laid on the occurrence of violent tonic
contractions of the limbs. As the reader, however, will
have inferred, these are not due to the sclerosis, but result
from the meningitis which is often an attendant condition.

Treatment. — The indications are in the first stage to di-
minish the amount of blood in the vessels of the meninges
and of the cord, and with this view, when I see a patient ex-
hibiting the early symptoms of sclerosis, I prescribe large
doses of ergot as recommended for spinal congestion. The
results have been exceedingly favorable, and I think it very
probable that by this treatment the advance of the disorder
has been checked. But in those insidious forms of the affec-
tion not accompanied in the early stage by symptoms indi-
cating hypersemia, and in those cases in which the morbid
process has apparently reached tliat stage in which there is
proliferation of the neuroglia, ergot can be of no service. On
the contrary, by lessening the amount of blood in the cord,
and hence interfering with its nutrition, it is calculated to
do harm. At this period I am inclined to think more
benefit is to be derived from nitrate of silver, cod-liver
oil, and the primary galvanic current, than from any other
measures.

In Dr. Pennock's case it is stated that the water-cure
was tried for a time with some temporary benefit, and Jac-
coud declares that hydrotherapy and mineral waters are still
the most efficacious remedies. My experience is not to this
effect. Several of my patients had, before coming under
my charge, made use of the means in question, but never
with the least favorable result. Even the Turkish bath,
which is so useful in some affections of the nervous system,
does harm in this. I have in a number of instances seen all
the symptoms aggravated by two or three such baths.

Counter-irritation I have employed repeatedly in all its
forms, but never with the slightest benefit.

For the relief of any pain that may be present, codein
in the dose of half a grain or more is to be preferred. Should

ANTERO-LATERAL SPINAL SCLEROSIS.

483

there be the least suspicion of syphilis, mercury and iodide
of potassium, as recommended on page 322, should be used
and continued for several weeks before it is deemed ineffica-
cious.

The bladder should always be looked after if there is any
paralysis, and the patient instructed to use the catheter at
stated periods.

CHAPTER YIIL

SCLEROSIS OF THE POSTERIOR COLUMN'S OF THE SPINAL
CORD {LOCOMOTOR ATAXIA).

Although other writers, and especially Eomberg/ had
described a disease answering to that now generally known
as locomotor ataxia, we are mainly indebted to Duchenne'
for giving a full and distinct account of an affection which,
before his studies, had scarcely attracted attention. In. ac-
cordance with the plan pursued in the present work, of des-
ignating diseases as far as possible by the lesion, and not by
the symptoms, I have decided to use the proper pathological
term for the affection under question, even though it be not
so familiar as the one usually employed.

Symptoms. — Posterior spinal sclerosis has no uniform set
of initial symptoms. Sometimes it begins with dull, heavy
pains in the small of the back or other part of the spinal
column, which are very soon followed by sharp, electric-like
pains, which shoot down the limbs along the course of the
nerves, and which are very generally taken by the patient
for twinges of neuralgia or rheumatism, or it may be first
manifested by a feeling of constriction around the body like
that which is so common in acute myelitis.

Again, the first symptoms are cerebral, and may consist
of attacks of vertigo, epileptic fits, disturbances of vision,
such as diplopia, ptosis, and defective accommodation.

* Lehrbuch der Nervenkrankheiten, Berlin, 1840 ; also Sydenham Society's
Translation, London, 1853.

' De I'Ataxie locomotrice progressive, Arch. Gen. de Med., 1858 ; also De
i'Electrisation localisee, Paris, 1861.

POSTERIOR SPINAL SCLEROSIS.

485

At other times tlie stomach and bowels are disordered ;
vomiting is frequent, and there may be diarrhoea or obstinate
constipation. Or, finally, the initial phenomena may be
connected with the sensibility, giving rise to anaesthesia,
and the various abnormal sensations connected therewith.

In whatever way it may begin, posterior spinal sclerosis
is soon chiefly manifested by disorders of motility, but in-
quiry reveals the fact that these are in reality secondary,
being dependent upon the diminished sensibility which al-
ways exists. As this is the essential feature of the disease,
I propose to inquire into its characteristics at some length.

If the lesion, as it usually does, exists in the dorso-lumbar
region of the cord, the first evidences of anjjesthesia or of
perverted sensibility are noticed in the feet. A common
feeling is one as if the toes are too large for the shoe, or as
if pieces of some plastic material are between them. Some-
times there are burning pains in the soles of the feet, and
very generally "pins and needles" and other forms of
numbness. A curious symptom is that, not only is the sen-
sibility lessened, but the transmission of sensitive impres-
sions to the brain does not take place with the normal de-
gree of activity. I have noticed this phenomenon in rather
more than half the cases that have come under my obser-
vation. In a lady, now a patient, a pin stuck into the calf
of the leg is not felt for fourteen seconds on the right side
and sixteen on the left. In a patient with posterior spinal
sclerosis, under treatment in the New York State Hospital
for Diseases of the Nervous System, if the feet are put into
hot water the sensation is not felt for almost three minutes.
As he said, " Mv feet might be scalded till the flesh dropped
off and I 'would not know it till the mischief was done.
Then I should feel it sharply." The explanation of this
symptom is to be found in the fact that the conducting
power of the posterior columns is lessened by the lesion, and
hence the brain does not receive in the usual time the im-
pressions made upon the nerves.

486

DISEASES OF THE SPINAL CORD.

The ability to feel pain is therefore diminished, but there
is, besides, a marked abatement of the tactile sensibility.
The extent of this can only be accurately measured by the
aesthesiometer. ' When this instrument is used, we find that
the two points can be widely separated and a single im-
pression only be felt on parts of the body which in the nor-
mal condition would give the sensation of two points at a
much less distance apart. A gentleman from Yirginia con-
sulted me recently, in whom I diagnosticated posterior spinal
sclerosis, and who, instead of being able to perceive the two
points with the end of the index-finger, when the twelfth
of an inch apart, could feel but one point, though the two
were separated to the extent of an inch and a half.

This loss of sensibility gives rise to some curious sensa-
tions, especially in the soles of the feet. These are usually
such as might be produced by the interposition of some sub-
stance between the foot and the shoe, or between the shoe
and the ground. One patient feels as if he has cushions on
the soles of his feet, another as if bladders of air are inter-
posed, another as if he is constantly treading on sticks, or,
if riding in an omnibus, as if the hem of a lady's dress had
got under his feet, and one a short time since described the
sensation to me as being like that which he thought he
would feel if his feet had been dipped into tar, and then
into sand.

In some cases the ability to distinguish differences of
temperature, or to appreciate the sensations produced by the
application of hot or cold bodies to the skin of the affected
parts, remains, but this is not, as some authors assert, a con-
stant phenomenon, for in the majority of cases the sensa-
tions produced by heat or cold are just as unappreciable as
those caused by any means capable of giving rise to sensitive
impressions.

But the symptoms by which a person with sclerosis of
the posterior columns of the spinal cord is recognized most
readily are those which relate to motility, and these phe-

POSTERIOR SPINAL SCLEROSIS.

487

nomena often make their appearance at a very early stage of
the affection. At that time there is no loss of motor power,
but there is an inability to coordinate the muscles — to bring
them into harmonious action, and thus to execute with pre-
cision the various voluntary movements. Thus, in the act
of standing, a great many muscles are simultaneously made
to contract, and each one to just that necessary degree which
is essential to maintaining the body in the erect posture.
Very often the first evidence of any motor difficulty is ex-
perienced in regard to this faculty of standing. This diffi-
culty is, however, not one of paralysis, for, if the patient
looks at his feet, he has no more trouble in standing alone
than a perfectly sound man.

A gentleman connected with the city government of
Brooklyn consulted me a short time since for an affection
which W' as very evidently posterior spinal sclerosis. The
first indication of disease, as he informed me, was that it
had been his habit, while at his morning ablutions, to shut
his eyes, and he had noticed, about two months previously,
that when he did so he could not maintain his equilibrium.
When he visited me he was unable to stand with his eyes
shut, and his gait was perfectly characteristic of posterior
spinal sclerosis.

Before the locomotion of tlie patient bcQpraes obviously
affected, he experiences inconvenience in placing his feet
upon small surfaces. Thus, when he attempts to enter a
carriage, he finds it difficult to guide his foot to the step,
and in mounting a horse he cannot readily hit the stirrup.
A gentleman from Maryland, w'ho is now a patient of mine,
and who is affected with the disease in question, tells me
that among the first symptoms which he noticed was the
difficulty he experienced in putting his foot into the stirrup.
He was obliged to use his hand as a guide. A like trouble
is frequently experienced in ascending a staircase.

The gait of a person suffering from sclerosis of the pos-
terior columns of the spinal cord is very much changed from

488

DISEASES OF THE SPINAL CORD.

tliat wliicli is natural. Instead of the foot bein^ placed upon
the ground with an easy motion, the heel a little in advance
of the sole, and the latter gliding down gently, the leg is, as
it were, jerked forward, the heel comes down suddenly, and
the sole follows, at a considerable interval, with an abrupt
flapping motion. In ordinary walking the placing of the
foot on the ground consists of one movement — there being
no stoppage between the touching of the ground by the heel
and the planting of the sole of the foot ; but, in the gait of a
person affected with posterior spinal sclerosis, the foot is
placed on the ground by two distinct movements, one for
the heel and another for the sole of the foot.

But, besides these irregularities of the progressive move-
ments, there are others which are likewise notable. The leg
is not carried directly forward, but is thrown out a little
from the median line, and this gives the patient a motion
like that of one walking on a tight-rope, and balancing him-
self with a pole. The object of this movement is doubtless
to widen the base, and thus to enable the patient to preserve
more readily his centre of gravity within it. In standing,
he, for the same reason, always separates the feet to a great-
er than normal distance.

In walking or standing, it will be observed that the pa-
tient affected with posterior spinal sclerosis keeps his eyes
fixed on his feet, or on the ground a little distance in ad-
vance. He is obliged to do this for the reasons — which with
others will be more fully considered under the head of pa-
thology— that the sensibility of the soles of the feet being
diminished, and the muscular sensibility being also lessened,
he is deprived, to a great extent, of the chief means by which
he was formerly enabled to recognize the position of his feet,
and of the dynamic condition of his muscles. He hence is
obliged to make use of another sense — his vision — in order
to obtain the necessary information. Therefore, when he
shuts his eyes, or is obliged to walk in the dark, he is de-
prived of the assistance of his eyesight, and, having only his

POSTERIOR SPINAL SCLEROSIS.

489

diminished tactile and muscular sensibility to guide him,
moves in an exceedingly timid and disorderly manner, or
else is unable to walk at all.

Under some circumstances he is unable to go forward,
even with the assistance of his eyesight. Experience has
taught him that he cannot rely on very important senses
which formerly he implicitly trusted. He loses confidence
in them, and is not reassured, even with vision to assist him.
He therefore uses extraordinary caution in walking over a
tiled floor, on the ice or snow, in descending a staircase, or
in crossing a street crowded with vehicles. In a recent
clinical lecture * delivered to the class of the Bellevue
Hospital Medical College, I called special attention to this
phenomenon of loss of confidence, and adduced several cases
in illustration of this point.

That there is little paralysis of motion to account for
these abnormalities, can be readily shown by a few inquiries
and experiments. Thus it will ordinarily be found that the
patient who is unable to stand with his eyes shut or take a
step in the dark, can push strongly with his legs, or walk a
short distance with a good deal of vigor. He is still good
for a " spurt," but long-continued muscular effort fatigues
him.

"When the lesion is above the origin of the nerves which
go to form the brachial plexus, the upper extremities are
the seat of symptoms which are similar to those described as
manifesting themselves in the legs. There are numbness
and other indications of anaesthesia, together with more or
less difficulty in coordinating the muscles into harmonious
action. The patient finds that the ends of his fingers have
lost, to some extent, their acute tactile sensibility, and that
there is restraint in the management of the fingers. He
experiences these difficulties in buttoning his clothes, in
picking up a pin, in writing, and in other actions requiring

' Clinical Lectures on Diseases of the Nervous System. Journal of
Psychological Medicine, January, 1871.

490

DISEASES OF THE SPINAL CORD.

nice manipulation. If he attempts, for instance, to carry a
glass of wine to his lips, he spills a portion of the contents ;
and, if told to place his finger on any particular part of
his face, the movement is accomplished with a wabbling
motion, and the finger is darted suddenly to the part as
it approaches it. All persons possess a knowledge of where
the different parts of their bodies are situated, which does
not depend upon the sense of sight, although probably
acquired by that sense and experience. There is such an
intimate and exact relation between the ends of the fingers
and the cutaneous surface of the body that, if a spot no
bigger than the head of a pin be made with a pencil on the
forehead, a person can close his eyes and touch it with the
end of his finger without difficulty every time he makes the
attempt. He can also, with the eyes shut, carry the end of
his fingers straight to the tip of his ear, the middle of his
eyebrow, or any other part of his body within reach. A
person, however, laboring under sclerosis of the posterior
columns of the spinal cord, cannot do any of these tilings.
He loses, at a very early period of the disease, that intimate
topographical relation which exists between the ends of the
fingers and the rest of the body ; and hence, when he closes
his eyes, and attempts to put the tip of his index-finger on
the end of his nose, he misses his aim, sometimes by as much
as two or more inches.

As in the legs, when the lesion is so low down in the cord
as only to affect them, there is no well-marked paralysis.
The grip of the patient is strong, and the dynamometer
shows the existence of considerable strength. He is,
however, not capable of continued muscular effort; and,
though he may be able to lift several hundred pounds, or to
carry another person around the room, his muscles are ex-
hausted with the gradual and regular expenditure of a much
less amount of force.

A phenomenon is often noticed as regards the upper
extremities, which also exists with the lower, but which

POSTERIOR SPINAL SCLEROSIS.

491

cannot be so readily manifested — and that is, that the patient
loses the ability to distinguish even considerable differences
between weights. In the normal condition, if two weights
differing in the ratio of thirty-nine to forty, are put one in
one hand and one in the other, the difference is perceived
without difficulty. The lower extremities, according to
Jaccoud, are not so sensitive, and cannot distinguish a less
difference than from about iifty to seventy grammes.

A person affected with posterior spinal sclerosis may have
an ounce-weight put into his hand, and if in a few seconds it
be removed, and one of half an ounce substituted, he will
not be able to tell correctly which is the heavier. Or both
hands may be extended, and the two weights placed simul-
taneously in them. The eyes should, of course, be closed.
Sometimes less differences can be perceived, but ordinarily
greater ones are not distinguished. In the case of a gentle-
man now under my charge, there is an impossibility of
telling which of two pieces of lead, the one weighing one
ounce and the other a pound, is the heavier. Spath ^ states
that, in a case under his charge, the patient could not dis-
tinguish between two weights, which differed as one to one
hundred.

No means for measuring the extent to which the patient
is able to determine the state of muscular contraction is at
all comparable to the dynamograph. The range of its useful-
ness is, however, limited — owing to the fact that posterior
spinal sclerosis is not very frequently seated high enough
in the cord to affect the muscles of the upper extremities.
When the lesion is not above the origin of the nerves which
go to form the brachial plexus, the line is straight, as in the
accompanying figure :

Fig. 22.

which represents the tracing made by a patient suffering
from posterior spinal sclerosis of the lower dorsal region of

' Beitrage zur Lehre von der Tabes dorsualis. Tubingen, 1864.

492

DISEASES OF THE SPINAL CORD.

the cord. But, when the seat of the disease in the cord is
anywhere between the fifth cervical and first dorsal verte-
brae, the ability to maintain a uniform degree of pressure is
impaired, and lines resembling the following are produced :

Fig. 23.

Both the above were made by the same patient, the upper
with the right and the lower with the left hand. He was
pefectly confident, till I showed him the tracings, that he
had exerted a uniform pressure while the paper was travers-
ing the pencil.

Under the name of bar^sthesiometer, Eulenberg ' has re-
cently described an instrument for estimating the sense of
pressure, by means of which very accurate determinations
can be made for different parts of the body. He succeeded
in demonstrating a considerable impairment of the sense of
weight in the great majority of cases of locomotor ataxia
examined, even when sensibility to pain, tickling, or electric
irritation, was but slightly affected, and the sense of tem-
perature wa^ normal.

The reflex power is generally notably increased. The
touch of the bedclothes, or even the rubbing of one leg
against the other, is sufficient to cause powerful contractions.

' Allg. Med. Cent. Zeitung, No. 93, 1869. Also Journal of Psychological
Medicine, October, 1870, p. 622.

POSTERIOR SPINAL SCLEROSIS.

493

Involuntary movements of the limbs, independent of those
due to reflex excitations, are rarely met with.
• The electro-muscular contractility is always increased.
It has already been mentioned that there are frequently
ocular troubles. These generally occur among the flrst
symptoms, and relate either to vision, to the movements of
the eyeball, or to both. Thus there may be amaurosis due
to atrophy of the optic nerve, or of the disk, a condition
readily detected by the ophthalmoscope. Or the third pair
of nerves may be involved, causing ptosis, divergent stra-
bismus, and dilatation of the pupil ; or the sixth pair of
nerves alone may be affected, causing convergent strabismus ;
or there may be only dilatation of the pupil and prominence
of the eyeball from the irritation propagated from the cilio-
spinal centre through the sympathetic nerves. These ocu-
lar troubles never take place in posterior spinal sclerosis ex-
isting below the cilio-spinal centre — the upper dorsal region
of the cord. The disturbances in the healthy action of the
stomach and intestines, which have already been alluded
to as common initial symptoms, are sometimes very distress-
ing. As the pains in the limbs are often taken for evidences
of neuralgia or rheumatism, so these gastric and intestinal
troubles are frequently regarded as indicating the existence
of dyspepsia. I have had a number of patients under my
charge who, with double vision, ptosis, incoordination, and
the other symptoms of posterior spinal sclerosis, had been
told that " it was all dyspepsia," because vomiting and gas-
tric pain were prominent features of the disease. These
symptoms are also due to the relations of the sympathetic
nerves with the spinal cord, and are not present in cases
where the lesion is low down in the lumbar region.

When, however, this part of the cord is involved, there
are very remarkable disorders of the genital system. These
consist of frequent nocturnal emissions with or without erec-
tions, or of an inordinate desire for sexual intercourse. A
gentleman who consulted me a few weeks ago, and who was

494

DISEASES OF THE SPINAL CORD.

affected with the disease in question, informed me that he
had several times had as many as eight seminal emissions in
one night, and that his sexual desire was almost inextin-
guishable.

Paralysis of the bladder is a common circumstance, and
the sphincter is not infrequently likewise affected. The
bowels are usually obstinately constipated.

The feeling of constriction around the body which is so
common a symptom in acute myelitis, and which is met with
in other organic affections of the cord, is rarely absent in
cases of sclerosis of the posterior columns.

Although the course of the disease in the great majority
of cases is onward to a fatal termination, there are often
periods of renlission as in other spinal affections, and it rare-
ly happens that the duration is not several years. A gen-
tleman from "Westchester County, in this State, has been af-
fected for over twenty years, and still walks tolerably well.
Another from Boston, sent to me by my friend Dr. Yan Bu-
ren, had been subject to the disease for over twelve years.
When I saw him he could not stand with his eyes shut, had
the characteristic ataxic gait, was subject to genital and
urinary difficulties, but yet was no worse than he had been
six years previously. Another, from Pittsburg, has been in
a stationary condition for several years ; and another, from
Binghamton, in this State, remains about as he was three
years ago. I could easily cite twenty others whom I occa-
sionally see professionally, who hold their own, and who
have been affected for from live to ten years. Romberg
gives the average duration at from ten to fifteen, Jaccoud
at from six to eight, and all authors agree that the course is
slow. Of ninety-one patients affected with sclerosis of the
posterior columns of the spinal cord who liave been under
ray charge during the last six years, three only have as yet
died, so far as I am aware. Of these, one had been affected
seven years, one eight years, and one eight and a half
years. There are several cases now under my charge in

POSTERIOR SPINAL SCLEROSIS.

495

which the affection has existed longer than either of these
terms.

The advance of the disease in the cord causes an aggra-
vation of all the symptoms, and the appearance of others
not previously noticed. The loss of motor power is now a
prominent feature, the muscles become atrophied, bed-sores
make their appearance, there is anasarca, and inflammations
of the joints may occur. These latter are not common, but
they are interesting as showing how disease of the cord may
interfere with the due nutrition of the various parts of the
body.

Their connection with posterior spinal sclerosis was first
pointed out by Charcot.' Previous to his observations, they
had been noticed, but they were, ascribed to an intercurrent
rheumatism, and, many years before locomotor ataxia was
recognized as an independent disease, the association of spi-
nal disease with inflammation of the joints was pointed out
by Prof. J. K. Mitchell,' of Philadelphia, and his son. Dr. S.
Weir Mitchell, with Drs. Morehouse and Keen,' had also re-
lated cases in which wounds of the spine had been followed
by arthritis. Since Charcot's paper was published. Dr. Ben-
jamin Bell * has cited cases of like affections coexisting with
posterior spinal sclerosis.

In the cases in question there is no fever, redness, or
pain. The swelling is due to the accumulation of liquids
in the synovial cavity, and this affection is the result of de-
fective nutrition of the bony, cartilaginous, and soft parts
connected with the joint.

These accidents make their appearance usually in the
interval between the occurrence of the shooting-pains so

* Sur quelques Arthropathies qui paraissent dependre de une lesion du
Cerveau ou de la Moelle Epiniere, Archives de Physiologie, No. 1, January,
1868, p. 161.

' American Journal of the Medical Sciences, vol. viii., 1831, p. 55.

* Gunshot Wounds and other Injuries of Nerves, Philadelphia, 1864.

* On Diseases of the Joints connected with Locomotor Ataxy, Medical Times
and Gazette, October 31, 1868.

496

DISEASES OF THE SPINAL CORD.

characteristic of the first stage and the motor difficulties
which mark the beginning of the second stage.

Of the ninety-one cases of posterior spinal sclerosis which
have come under my observation, in five only were there
any difficulties of the joints.

Death may take place either as the direct consequence
of the lesion of the spine, or as the result of some intercur-
rent affection such as pneumonia, dysentery, phthisis, or
cystitis.

Causes. — I have been very unsuccessful in my efforts to
ascertain the cause in the greater number of persons, affected
with sclerosis of the posterior columns of the sj^inal cord,
who have been under my observation. The opinion is very
prevalent that it is generally the result of excessive vene-
real indulgence ; and, although this is undoubtedly some-
times a cause, it certainly is not so common a one as is
generally supposed. I have carefully inquired into the
etiology of all the cases I have seen, and have only been
able to assign inordinate sexual indulgence as the cause in
seven. Injuries were apparently the cause in four cases,
standing in a constrained position in three, the excessive
use of alcoholic liquors in three, a syphilitic taint in three,
undue mental exertion and anxiety in two, and in the re-
mainder there w^is nothing that could be assigned as an ex-
citing cause. So far as we know, it would appear that the
etiology is identical with that of antero-lateral spinal scle-
rosis. As regards the predisposing causes of age, sex, and
hereditary influence, the similarity is equally well marked.
Of the ninety-one cases observed by me, two only were in
women.

Diagnosis. — A consideration of the symptoms detailed in
the foregoing pages will prevent posterior spinal sclerosis
from being confounded with any other affection of the spi-
nal cord. It may, however, be difficult at times to dis-
criminate between it and lesions of the cerebellum, and the
distinction has frequently not been made by very skilful

POSTERIOR SPINAL SCLEROSIS.

497

diagnosticians. At one time Duehenne held the view that
locomotor ataxia was really the result of a lesion of the
cerebellum, but he subsequently* retracted this opinion,
and now believes that the spinal cord is the seat of the dis-
order.

In a recent memoir " I have endeavored to point out the
differences between cerebellar disease and the affection now
called posterior cerebral sclerosis. In that essay I have
said: "Derangement of locomotion certainly does result
from injury or disease of the cerebellum. Experimental
physiology, as well as pathology, proves this. Beyond a
doubt the disorder is, however, clearly due to vertigo.
There are, moreover, headache, vomiting, and eventually
in some cases hemiplegia, generally of the opposite side to
that of the cerebellar lesion, a fact at variance with Larrey's
assertion. The gait of a person thus affected is exactly
similar to that of a drunken man. As Carre says, the
movemejits are not abrupt, jerking, and exaggerated, as
they are in locomotor ataxia. They are more uncertain,
and do not depend upon any defect of coordination, but
upon weakness of the voluntary power.

" When either of the peduncles of the cerebellum is af-
fected there is an irresistible impulse to go sideways, and
sometimes gyratory movements are produced."

The characteristic symptom of cerebellar lesion is ver-
tigo ; and, although this is sometimes met with in posterior
spinal sclerosis, it is not a prominent feature, and is rarely
present at all except in the very earliest stage.

In cerebellar lesions the cutaneous sensibility is unim-
paired, whereas in posterior spinal sclerosis it is always di-
minished.

A patient with disease of the cerebellum can stand and

' Diagnostic dififerential des affections cerebelleuses et de I'ataxie locomo-
trice progressive. Gazette Hebdomadaire, 1866.

" The Physiology and Pathology of the Cerebellum. Journal of Psycho-
logical Medicine, April, 1869.
32

498

DISEASES OF THE SPINAL CORD.

walk better with his eyes shut than with them open, for the
vertigo is not in the former condition felt to the same ex-
tent. The reverse is true of posterior spinal sclerosis. The
history of the case will also serve as a good guide to the
diagnosis. In the latter or even in the developed stage of
posterior spinal sclerosis it would be difficult to mistake it
for any other affection.

Prognosis. — The prognosis is no more favorable than that
of antero-lateral spinal sclerosis. A few cases are cured,
more are relieved, but the great majority go on unchecked.
Of the ninety-one cases upon which this chapter is based,
live were cured. Of these, two were probably of syphilitic
origin, but in the other three no such cause was at all prob-
able. One of them was a woman.

The cases in which amelioration has been produced are
more numerous. In fact, it is not at all uncommon to suc-
ceed in retarding the onward progress of the disease, and of
thus prolonging the life of the patient.

Morbid Anatomy. — Sclerosis of the posterior columns, as
of the anterior, may be either diffused, multiple, or cortical.
It may be restricted to the white substance of one or both
posterior columns, or may also involve the gray matter.
The posterior roots of the spinal nerves may also be impli-
cated in the lesion.

The situations of the lesions and their character were
well known to Romberg ' before the researches of Du-
chenne, Charcot, and others. Thus he states that he was
present at the post-mortem examination of the cord of a
former patient. The organ was reduced one-third in diam-
eter, and the atrophy was confined to the lower part of the
posterior columns. The posterior nerve-roots were also in-
volved, but the anterior columns were healthy.

I have stated under the head of symptoms that posterior
spinal sclerosis is often accompanied by " head-symptoms,"
and may be first manifested by an epileptic convulsion. So
1 Op. cit., p. 399.

POSTEKIOR SPINAL SCLEROSIS.

499

generally is it the case that there are cerebral difficulties
that I hesitated for some time whether the disease should
not be classed among those affecting the cerebro-spinal sys-
tem.

The lesions found in the brain never involve primarily
the hemispheres. To be sure, it is sometimes the case that
there are mental difficulties, but these come on toward the
close, and are probably the result of defective nutrition.

The cerebral lesions are in very intimate relation with
the posterior spinal columns. They are therefore met with
in the lower cerebellar peduncles, in the restiform bodies,
and in the optic thalami, and consist of atrophy with de-
generation. The optic nerve is apt to participate, and
hence the principal ophthalmoscopic appearances to which
attention has already been called.

The other nerves which are often affected are the audi-
tory, the third, and the sixth.

Romberg ' was well acquainted with the fact that the
cerebral nerves are frequently atrophied in the disease un-
der consideration.

Although it is probable that the sympathetic is atrophied
in some part of its extent, in many cases of posterior spinal
sclerosis, the fact has not been demonstrated, except as re-
gards one instance reported by Donnezan, in which a fila-
ment from the superior cervical ganglion was found atro-
phied. The ganglion itself was healthy.

In the later stages of the affection the muscles may ex-
hibit a condition of atrophy. In such cases their tissue will
be found on microscopical examination to have undergone
fatty degeneration and substitution to a greater or less ex-
tent.

Pathology. — The theory of posterior spinal sclerosis which
is generally held is, that the lesion impairs a faculty by
which the muscles are brought into harmonious action — a
faculty of coordination. According to this view, the first

1 Op. cit., p. 399.

500

DISEASES OF THE SPINAL CORD.

thing to be done was to locate this faculty in an organ, and
Duchenne, with whom it originated, and who still holds
it, adopting the ideas of Flourens and others, placed this
faculty in the cerebellum, and therefore regarded what he
designated progressive locomotor ataxia as a disease of the
cerebellum.' Thus he says :

" In conclusion, regarding the order of appearance, and
the habitual progress of the symptoms which mark the three
periods of progressive locomotor ataxia, we find that the
central morbid action which produces the phenomena symp-
tomatic of this disease begins in general in the motor nerves
of the eye, and in the tubercular quadrigemina, extending
thence to the superior and inferior cerebellar peduncles and
finally to the cerebellum."

As already stated, Duchenne has since abandoned this
view of the location, and now assigns its seat to the poste-
rior columns of the cord, but, in order to make the morbid
anatomy agree with the theory of the disease which he holds,
he places his faculty of coordination in the cord. But, al-
though it has been established by numerous post-mortem
examinations that the cerebellum is not the seat of lesion
in cases of locomotor ataxia, and although the difierential
diagnosis between diseases of the cerebellum and posterior
spinal sclerosis has been very clearly made out, there are
some who still hold the view that, although the cerebellum
shows no traces of disease, and that, although the posterior
columns of the spinal cord may be in a state of sclerosis, the
symptoms are the result of an interruption to the passage,
from the cerebellum through the posterior columns to the
spinal nerves, of that force which coordinates the muscles
into harmonious action. In the memoir to which reference
has already been made, I have entered at length into the
consideration of the question of the location of a coordinat-
ing faculty in the cerebellum, and have, I think, adduced
sufficient facts and arguments to show that coordination is

' De rfilectrisation localisee, deuxiSme Edition, Paris, 1861, p. 611.

POSTERIOR SPINAL SCLEROSIS.

501

not one of its functions. "Without going into a full account
of the subject, a synopsis of the conclusions arrived at will
probably not be deemed out of place :

1. The consequences of removal of the cerebellum, if
the animal survives the immediate effects of the injury,
are not enduring. This conclusion is supported by experi-
ments by Flourens,^ Harting,' Wagner,' Dalton,* myself,"
and others. The physiological inference, of course, is, that,
if the faculty of coordination resided in the cerebellum, it
ought to be permanently removed with the ablation of the
organ.

2. The entire removal of the cerebellum from some ani-
mals does not apparently interfere in the slightest degree
even for a moment with the regularity and order of their
movements. I have performed a number of experiments
with reference to this point, on different classes of animals.
They prove very clearly that the cerebellum is not the gen-
erator of coordinating power in all animals that have it :
a fact in comparative physiology which is fatal to the hy-
pothesis that this is its function in man.

3. The disorder of movements which results in birds and
mammals immediately after injury of the cerebellum is not
due to any loss of coordinating power, but is the result of
vertigo.

If the cerebellmn be removed from a pigeon it exhibits
disorder in its movements, but a careful examination of the
phenomena exhibited, shows that it is suffering from a
vertiginous sensation. Even when placed upon its breast

' Recherches experimentales sur les proprietds et les fonctions du systeme
nerveux, Paris, 1842.

* Experimenta quaedam de affectibus laesionum in partibus encephale, 1826.

2 Nachrichten von der Universitat und der Konigl Gesellschaft der Wissen-
schaften zu Gottengen ; also Journal de la physiologic de I'homme et des ani-
maux, Avril, 1861.

•* American Journal Medical Sciences, January, 1861, p. 83; also Treatise
on Human Physiology, 4th edition, ISB?, p. 416.
6 Op. cit., p. 24.

502

DISEASES OF THE SPINAL CORD.

and allowed to remain at rest, there is a trembling and
swaying of the body, such as is produced by alcoholic intoxi-
cation. Exactly such symptoms can be caused by giving
pigeons bread soaked in alcohol.

4. The phenomena of cerebellar disease or injury, as ex-
hibited in man, are not such as show any derangement of the
coordinating power.

Many cases are on record which support this proposition.
Andral ^ states that, of ninety-three cases of cerebellar dis-
ease which he has studied, only one appeared to support the
theory which locates the coordinating power in the cere-
bellum.

Many special instances might be brought forward, and
several have occurred in my own practice. The case of
Alexandrine Labrosse, reported by Combette,' is, however,
worth referring to more specifically. His paper is entitled
" Case of a young girl who died in her eleventh year, in
wHpm there was complete absence of the cerebellum, of the
posterior peduncles and of the annular protuberance."
Magendie examined the brain after her death, and satisfied
himself that the defect was congenital. As M. Combette
remarks in regard to this case, Alexandrine Labrosse had
been able to walk for several years, but always in an uncer-
tain manner. Gradually her legs lost their strength, and
she became paraplegic. She preserved the use of her upper
extremities to the last. It is very evident, therefore, that
the weakness of her legs was due to paralysis, for, had it
been the result of incoordination, the arms must necessarily
have participated.

For these reasons, I think, it cannot be considered with
any degree of probability that the cerebellum has any thing
whatever to do with the symptoms manifested in sclerosis
of the posterior columns of the cord. Neither is it, in my

^ Clinique Medicale, seconde edition, tome v., p. 735.
* Journal de Physiologic 6xperimentale et pathologique, par F. Magendie,
tome xi., Paris, 1831, p. 27.

POSTERIOR SPINAL SCLEROSIS.

503

opinion, necessary to assume the existence of an organ
whose office it is to exercise a coordinating power.

Other authors have ascribed the incoordination which is
so prominent a phenomenon of posterior spinal sclerosis to
the loss of what they call the muscular sense.

Sir Charles Bell ' has argued strongly in support of the
existence of such a sense. He enunciates his theory in the
following sentence :

" Between the brain and the muscles there is a circle of
nerves ; one nerve conveys the influence from the brain to
the muscle, another gives the sense of the condition of the
muscle to the brain."

It is by this connection that we are enabled, according
to Sir Charles Bell and other physiologists, to form an idea
of the state of contraction of a muscle, and to lessen or in-
crease the contraction as may be necessary. According to
some writers, in posterior spinal sclerosis the patient loses
this muscular sense, or is unable to exert it, for the reason
that the spinal columns through which the perception
reaches the brain are, by disease, rendered incapable of
transmitting it.

In my opinion — and I shall endeavor to support it pres-
ently— there is no such a perception as that referred to, and
its existence is certainly not established by the case reported
by Dr. Ley to Sir Cliarles Bell, and which is incorrectly
quoted by Trousseau ; for it proves nothing more than that
defective sensibility existed, and that the sense of sight had
to be used in order to obtain a correct idea of what the in-
sensible muscles were doing.

A lady having been recently delivered, and having suf-
fered severe haemorrhage, was seized soon afterward with
headache and numbness. Dr. Ley was called to see her.

"I found her," he says, "laboring under severe head-

' On the Nervous Circle which connects the Voluntary Muscles with the
Brain. Philosophical Transactions. Also, The Nervous System of the Human
Body. London, 1830, p. 225.

504

DISEASES OF THE SPINAL CORD.

ache, not confined to, but infinitely more violent upon one
side than the other, and occupying the region of the tem-
poral and occipital bones above the mastoid process, and
attended with considerable pulsation.

" Upon one side of the body there was such defective
sensibility, without, however, corresponding diminution of
power in the muscles of volition, that she could hold her
child in the arm of that side so long as her attention was
directed to it ; but, if surrounding objects withdrew her
from the notice of the state of her arm, the flexors gradu-
ally relaxed, and the child was in hazard of falling. The
breast, too, upon that side, partook of the insensibility,
although the secretion of milk was as copious as in the other.
She could see the child sucking and swallowing, but she had
no consciousness from feeling that the child was so occupied.
Turgescence of that breast produced no sufiering, and she
was unconscious of what is termed the draught on that side,
although that sensation was strongly marked in the other
breast.

" Upon the opposite side of the body there was defective
power of motion, without, however, any diminution of sen-
sibility. The arm was incapable of supporting the child,
the hand was powerless in its grip, and the leg was moved
with difiiculty and with the ordinary rotatory movement of
a paralytic patient, but the power of sensation was so far
from being impaired that she constantly complained of an
uncomfortable sense of heat, a painful tingling, and more
than the usual degree of uneasiness from pressure or other
modes of slight mechanical violence."

After a few months she died ; having, in the mean time,
received no improvement from the active treatment em-
ployed, and having also become pregnant again. On post-
mortem examination there were found evidences of chronic
inflammation of the membranes of the brain. The cord
was not examined. Certainly this case presents nothing
which may not be met with in any patient who has anses-

POSTERIOR SPINAL SCLEROSIS.

505

tliesia on one side and paralysis of motion on the other. I
have observed a number of similar cases, and they neither
prove the existence of a muscular sense, nor do they have
any special bearing on posterior spinal sclerosis beyond the
fact that they exhibit deficient sensibility.

But, before proceeding to the further discussion of this
subject, clear ideas should be entertained relative to the
anatomy and physiology of the spinal cord. The researches
of Dr. J. Lockhart Clarke have given us very exact infor-
mation on these points, and I shall therefore quote from him
in full.'

As Dr. Clarke states, before he began his researches on
the structure of the spinal cord, it was universally taught,
both in England and abroad, that the posterior roots of the
spinal nerves vt^ere attached exclusively to the lateral col-
umns of the cord ; whereas he showed, what is now univer-
sally admitted, that they are attached immediately to the
posterior columns, and not at all to the lateral. The im-
portance of this fact in both a physiological and pathological
point of view, and especially in its relation to posterior spi-
nal sclerosis, will presently appear.

In Fig. 24, which represents a transverse section of the
left lateral half of the lumbar enlargement of the cord, the
posterior nerve-roots {1} are seen to enter through nearly the
entire breadth of the posterior column (a) ; and in Fig. 25,
which represents a longitudinal section of the cervical en-
largement of the cord, we see the course of the roots of four
consecutive nerves (P, P, P, P) within the cord. These
roots are of three kinds : The first kind {a, a, a, a) enter
the cord transversely, and pursue a very remarkable course.
Each bundle, after traversing the longitudinal fibres of the
posterior column (P C) in a compact form, and at a right
angle, continues in the same direction to a considerable but

* See Dr. Clarke's paper on " Locomotor Ataxy," in British Medical Journal,
September 25, 1869, p. 344, from which I take this account and the accom-
panying woodcuts.

506

DISEASES OF THE SPINAL COKD.

Fig. 24.

variable depth within the gray substance (G), dilating and
again contracting, so as to assume a fusiform appearance.

Fig. 25.

It there bends round upon itself, at a right or more obtuse
angle, and, running for a considerable distance in a longitu-

POSTERIOR SPINAL SCLEROSIS.

507

dilial direction down the middle of the cord, sends forward,
at short intervals, into the anterior gray substance, a series
of fibres, some of which mingle with those of the anterior
roots (A), while others enter the anterior white column, as
at AC, AC, in which they run longitudinally, both upward
and downward.

The second kind of posterior roots (J, 5, h) also traverse
the posterior column transversely, but sometimes a little
obliquely from without inward. Their component fibres
are finer than those of the other bundles, measuring about
the , 0 th of an inch in diameter. Some of these fibres
cross over transversely to the gray substance of the opposite
side through the posterior commissure behind the canal.
Others extend into the posterior and lateral white columns
of the same side, while the rest may be traced deeply into
the anterior gray substance (G, Fig. 23), where they diverge
in different directions, and are ultimately lost to view.

The bundles forming the third kind of posterior roots
(e, c, c, Fig. 23) enter the end obliquely. A few of their
fibres proceed near the surface of the posterior column both
upward and downward, and pass out again with roots above
and below them. The rest cross the posterior column ob-
liquely and chiefly upward, a small number only running
downward. Interlacing at the same time with each other
and with the roots already described, these fibres diverge,
and for the most part reach the gray substance at points
successively more distant from their entrance into the cord
in proportion to the obliquity of their course, the most di-
vergent and superficial taking a longitudinal course at least
for some distance, with the fibres of the posterior column,
among which they are lost. From these investigations
{Philosophical Transactions^ 1853), Dr. Clarke inferred that
the posterior white columns of the cord cannot be the only
channels for the transmission of sensory impressions, an in-
ference which was verified two years later by the experi-
ments of Brown-Sequard {Gazette Medicale, 1855).

508

DISEASES OF THE SPINAL CORD.

Such being the anatomical connection of the posterior
nerve-roots with the posterior columns of the cord, it is evi-
dent that scarcely any part of the length of those columns
can be damaged either by injury or disease without involv-
ing destruction of a corresponding number of nerve-roots ;
and, since reflex action of the cord requires that impressions
be conveyed by nerve-roots to the gray substance, the dimi-
nution of reflex action in cases of injury to the posterior col-
umns is thus readily explained.

Dr. Clarke, in the anatomy and physiology of the pos-
terior nerve-roots and their relations to the cord, which he
has thus so satisfactorily elucidated, presents a theory of the
phenomena of incoordination met with in posterior spinal
sclerosis, to which I will allude more specifically directly.
In the mean time a few words in reference to the " muscular
sense " are necessary to the understanding of the whole
subject.

Landry ' declares that, whenever a muscle is caused to
contract, the brain perceives the seat and the extent of the
contraction. I am very sure that no sensation starts from
the muscle which can give the brain any idea on the sub-
ject. As Trousseau " remarks :

" An important distinction must be drawn between the
consciousness of a movement which has been executed, and
the consciousness of the muscular contraction which per-
forms the movement. When after shutting our eyes we ex-
ecute without effort a pretty extensive movement, we are
unable, even on paying the strictest attention, to feel the
contraction of our muscles, although we may feel the move-
ment communicated to the lever by the contracted muscles.
This fact is so true, that, when we ask an intelligent person,
who knows nothing of anatomy and physiology, which is
the seat of the movements through which the fingers are
flexed or extended, he immediately points to the hand, and

' Memoire sur la paralysie du sentiment d'activitd musculaire, Paris, 1856.
» Op. cit., p. 159.

POSTERIOR SPINAL SCLEROSIS. 509

never to the forearm. It is only when the muscular effect
is considerable and kept up for a long time, that it is per-
ceived where the contraction really occurs. Normally, then,
we have no consciousness of muscular activity, but merely
the consciousness of the movement itself, which is a perfect
ly different thing."

In a very thorough essay on the subject. Dr. Bastian ' has
discussed the whole subject of the " muscular sense." He
denies — and I think with good reason — the existence of any
such special sense. In his opinion, there is no consciousness
of the state of muscular contraction, and that the estimations
by which we regulate the extent to which it is necessary, for
instance, to contract the muscles of the upper extremity to
sustain a certain weight in the hand, are " inferences based
upon previous sensory impressions of the passive kind, upon
impressions emanating from the skin, from the joints, and
from the muscles themselves, so that in my opinion there
are no conscious impressions derivable through the ' muscu-
lar sense.' " This, as I think, is not to be considered as an
appanage of the intellect, but rather as an unconscious or-
ganic guide in the performance of voluntary movements.
Why, it may be asked, do I not, as Trousseau has already
done, deny its existence altogether ? And to this I should
reply by saying : " Although there is no evidence to lead us
to believe that we derive any conscious impressions through
the intervention of this so-called. ' muscular sense,' there is
evidence to show that the brain is assisted in the execution
of voluntary movements by guiding impressions of some
kind, which, while they differ from the impressions produ-
cible by means of the ordinary cutaneous and deep sensibility,
may differ still further from these, owing to the fact of their
not being revealed in consciousness at all."

This impresses me as being a very philosophical view of
this rather difficult question, and it is in part sufficient to ex-

* Remarks on the " Muscular Sense " and on the Physiology of Thinking.
British Medical Journal, May 1, 1869, and subsequent numbers.

510

DISEASES OF THE SPINAL CORD.

plain the incoordination existing in cases of posterior spinal
sclerosis ; but, for the full understanding of the subject, it
appears to me we must bring forward another fact in the
physiology of the spinal cord which has not hitherto, so far
as I know, been made applicable. The spinal cord serves
two distinct purposes in the economy. It transmits nervous
force to and from the brain, and it is a centre which gener-
ates nervous force. Keferring now to the anatomical de-
tails given by Dr. Lockhart Clarke, we find that the pos-
terior nerve-roots not only reach the white substance of the
posterior and antero-lateral columns, but that they are in
intimate relation with the gray matter. Kow, the white
substance simply serves for the transmission of nervous force,
the gray elaborates it. Hence a great many of the muscular
actions which we perform are done through the agency of
this gray matter of the cord, and are without the interven-
tion of the brain, and the brain can only be brought to bear
upon them through the agency of the white substance. The
states of muscular contraction are, therefore, in all proba-
bilitv, perceived by the gray substance of the cord, and, as
the brain has no consciousness of the perceptions of the cord,
we are not made aware of the states of muscular contraction.
The muscular sense, therefore, does not exist, at least in the
same manner as do the other senses.

In sclerosis of the posterior columns of the spinal cord
the lesion generally involves the posterior nerve-roots, the
posterior white substance, and the posterior cornua of gray
substance. Hence the cord loses both in the ability to trans-
mit and to generate nervous force. Those unconscious acts
of muscular coordination which are regulated by the gray
substance of the spinal cord can no longer be perfectly ac-
complished, and the brain is brought to assist in the deter-
mination through the sense of sight. The patient cannot
stand well with his eyes shut, or walk in the dark, or deter-
mine differences of weight, because he is relying altogether
on the perceptive faculty of the spinal cord, and this organ

POSTERIOR SPINAL SCLEROSIS.

511

is not in a condition to perform its work with precision ;
and his movements and muscular contractions are rendered
still more uncertain from the fact that the cutaneous sensi-
bility is diminished.

In the normal condition we frequently — in determining
weights, for instance — are greatly assisted by the sense of
sight, and there is nothing surprising in the fact that, in a
disease like posterior spinal sclerosis, the spinal cord should
be unable to perceive states of muscular contraction without
the assistance of the brain. And, as the conducting power
of the cord is also lessened, the brain cannot act with its full
power ; and, therefore, even with all the assistance to be de-
rived from the chief generator of nervous force in the body,
the patient's muscles are not so well coordinated as in health.

Dr. Lockhart Clarke, in the memoir already cited, ex-
plains the incoordination upon another principle, which,
although, as I think, not sufficient to account for the phe-
nomenon, may, and probably does, exercise some influence.
His view is, that there is a physiological state of the muscles
dependent on reflex action, that is absolutely essential to the
proper coordination of voluntary movements, and that is,
their tonicity, or that moderate but constant state of con-
traction which keeps the antagonist muscles, or those that
are variously opposed to each other, in equilibrium or static
tension. In the performance of voluntary movements a
constantly-varying number of muscles, each of which differs
more or less in force and in the particular direction which it
gives to the limb or part, are associated together in action
in an endless variety of ways. Each of the muscles that
compose these varying groups must contract either simul-
taneously or successively to a certain j)articular extent, with
a certain degree of force, and with a certain degree of rapid-
ity, in relation to the actions of the others, according to the
resultant direction desired in the voluntary eff'ort ; and this
endless variety of ways, in which a constantly-varying mim-
bei of muscles are balanced against each other in contrac-

512

DISEASES OF THE SPINAL CORD.

tion for the performance of constantly-varjing and compli-
cated voluntary movements, affords the most exquisite and
beautiful example of what, in physical science, is termed
the composition of forces. In this balancing of muscular
force we have to learn, by experience, and to remember the
exact voluntary effort required to contract each muscle to
its proper extent, with its proper force, and with its proper
degree of rapidity, in relation to the action of the others
that complete the group employed. Now, it is evident that
if some of the muscles of the group employed have lost their
normal tension or tone, they will not properly respond to
the intentions of the voluntary stimulus, and will fail to
perform their proper part in balancing the eff*ects of the
other muscles of the group that retain their tension, in the
execution of any given movement. In proportion, there-
fore, to the exact amount of tension lost by any muscle or
muscles of the group, and the number of muscles that have
lost that tension, there must necessarily be a proportionate
amount of disorderly movement of incoordination. But it
appears to be satisfactorily proved, by the experiments of
Brondigeest, Rosenthal, and others, that this constant ten-
sion or tone of the voluntary muscles is due to a constant
reflex action of the cerebro-spinal centres, and is immedi-
ately dependent on impressions conveyed from the muscles
to those centres by the posterior roots of the nerves. Now,
Dr. Clarke has shown how these posterior spinal roots are
spread out through the posterior columns of the cord ; how
impossible it is for these columns to be destroyed to any
great extent without involving destruction of the nerve-
roots ; and how, consequently, the columns are so destroyed
in locomotor ataxia. But, except in the very last stage of
this malady, all the posterior roots are not injured by disin-
tegration, and some of them are still competent to carry
impressions to the gray substance of the cord ; so that some
of the muscles retain their tone, while others lose it to a
greater or less extent.

POSTERIOR SPINAL SCLEROSIS.

513

This is Dr. Clarke's explanation of the peculiar feature
of posterior spinal sclerosis, in almost his own words. That
it is ingenious and plausible, all physiologists and patholo-
gists will admit.

Treatment. — A great many medicines have been em-
ployed in the treatment of sclerosis of the posterior columns
of the spinal cord, but few have been productive of any
material benefit. Leaving out of mention those which my
experience has taught me are inefficacious, I will specifically
refer only to those which I have seen produce some amelio-
ration of the symptoms.

As in the corresponding afiection of the antero-lateral
columns, ergot in large doses is often beneficial in the early
stages of the disease, and the bromide of potassium may be
combined with it in doses of from thirty grains to a drachm
three times a day. Cod-liver oil is always advantageous,
and the primary galvanic current applied as recommended
for antero-lateral sclerosis is a main feature of the treat-
ment.

I ordinarily begin the treatment of every case of pos-
terior spinal sclerosis by these means if the disease has not
yet passed beyond the first stage — that which is character
ized by the presence of the shooting electric pains previous-
ly described — employing at the same time measures directed
to the relief of particular difiiculties. Thus, for gastric de-
rangements, bismuth will often prove of service, or the
constant galvanic current may be passed through the pneu-
mogastric nerve, the positive pole being placed over the
nerve in the neck, and the negative rubbed over the epigas-
tric region, or, what is usually still more efficacious, Bou-
dault's pepsin may be given in doses of fifteen or twenty
grains with each meal. I have frequently had the most
satisfactory results from this agent when all others have
failed.

The pains in the back and around the abdominal or
thoracic regions are best combated with codeine in doses of
33

514

DISEASES OF THE SPINAL CORD.

from half a grain to one or two grains, according to circum-
stances.

If the case comes under observation when the motorial
difficulties are well marked, or, if, after having used it for a
month, no decidedly beneficial eflPect follows the treatment
just specified, I omit the ergot, and use instead, the nitrate
of silver in doses of the quarter of a grain three times a day.
This remedy has apparently proved serviceable in several
cases which were well advanced, but I am not able to speak
definitely on the subject, for the reason that with it bromide
of potassium, and especially galvanism, were used. Two
cases were cured by the combined remedies — one of them
was that of a distinguished journalist, who, in the first place,
was treated with ergot, and subsequently, when this medi-
cine appeared to be of no further efiiect, with the nitrate of
silver. At the present time this gentleman is well, free
from pains, able to coordinate, and with no symptom of the
afiection remaining. The disease was first manifested by an
epileptic paroxysm, and soon afterward ocular troubles made
their appearance. He was under treatment for about four
months. The other case was that of a lady of this city.
The disease, in her, began with pain in the back, and elec-
tric pains in the lower extremities. Ptosis, dilatation of the
right pupil, and diplopia followed, and then gradual loss of
sensibility in the soleS of the feet, and difficulty in coordi-
nating the muscles of the legs. The disease had lasted two
years and a half when the patient came under my charge.
She was treated with the nitrate of silver and the other
remedies mentioned for nearly a year, and throughout the
whole period gradually improved till her recovery was com-
plete. The nitrate of silver was suspended for a week after
each month of its administration.

In a third case ergot and nitrate of silver were given to-
gether without the bromide of potassium. This case was
that of a gentleman, a merchant of this city, residing in
Bridgeport, Connecticut. He had had ocular troubles, and

POSTERIOR SPINAL SCLEROSIS.

515

was suffering from pains, incoordination, plantar anaesthesia,
paralysis of the bladder, and swelling of the right knee,
when he came under my charge, being sent to me by my
friend Dr. Hubbard, of Bridgeport. The disease had then
lasted only a few months. With the medicines, the constant
galvanic current to the spine and spinal nerves was em-
ployed. He was entirely cured in less than three months.
In all cases inquiry should be made with reference to the
existence of a syphilitic taint. If affirmative results follow
the investigation, the iodide of potassium should be admin-
istered in gradually-increasing doses as recommended for
acute spinal meningitis, or in combination with corrosive
sublimate, according to the formula given on page 322,
recollecting that galvanism is likewise to be used, and such
other treatment as the special symptoms may seem to re-
quire. Two cases were cured by this treatment ; one of
them was that of a gentleman from the West — a fully-de-
veloped case — who had been treated by my friend Dr.
Bumstead for other syphilitic troubles, and who sent him
to me for his spinal difficulty. The incoordination, plantar
anaesthesia, pain in the lumbar region, and the electric
pains, were all present, together with slight diplopia. He
was under treatment for about t'en months. I met him a
few weeks since in a railway-car, the picture of health, and,
as he told me, perfectly well.

The other case occurred in the person of a gentleman of
this city, and was similar in general features to the preced-
ing. A cure was obtained, after like medication, in six
months.

In several cases I have obtained ameliorations by the
use of phosphoric acid, phosphorus, and chloride of barium.
My experience with the latter medicine is not as yet suffi-
cient to enable me to say that it has effected a cure, but the
therapeutical promise is good. I have administered it in
eight cases with decided benefit. Five of these are still un-
der treatment with it. If the vesical sphincter be paralyzed,

516

DISEASES OF THE SPINAL CORD.

belladonna may be used with advantage. Hydro-therapeu-
tics in all forms,* counter-irritation of all kinds, and fara-
disation, have never, according to my experience, been of
the slightest benefit, except as regards the use of the latter
to the affected muscles. The ether-spray recommended by
Jaccoud has been entirely inefficacious in my hands, and
the same may be said of all plasters and embrocations.

One auxiliary means of treatment I have lately em-
ployed with advantage, and that is, keeping the patient as
much as possible from using the groups of muscles which
have lost their coordinating power, and requiring him, when
he walks, to employ crutches to assist him. By systemati-
cally carrying out this plan the nervous force of the patient
is not wasted, and a diseased organ, such as is his spinal
cord, is not overtasked.

Without making a separate chapter for the subject, it
may be well to mention here the fact that chronic myelitis
may affect a lateral half of the cord embracing in the lesion
one antero-lateral and one posterior column, or any other
combination of columns. Several such have come under
my observation, and an interesting case of lesion of an an-
tero-lateral and posterior column of one side is reported in a
clinical lecture on SpiualTaralysis,' delivered by me at the
Bellevue Hospital Medical College. The patient is still at
the New York State Hospital for Diseases of the Nervous
System, and is steadily improving.

> Journal of Psychological Medicine, January, 1871.

CHAPTER IX.

TUMORS OF THE SPINAL CORD.

FoLLowrsTG the example of Jaccoud, I shall consider
under one head, tumors of the cord, of the membranes, and
those which, growing from the interior surfaces of the ver-
tebrae, may compress the cord, and thus interfere with its
functions by deranging its structure. In the present state
of our knowledge, we have no sufficiently exact data by
which to discriminate between these several growths.

Symptoms. — The phenomena which result from intra-
spinal tumors, like those due to congestion, are of two cate-
gories, resulting as they do either from irritation or com-
pression. Under the first head are embraced pain in the
back, in the limbs, and in the viscera, if the posterior col-
umns are mainly the seat of the lesion or subjected to the
pressure of a vertebral tumor, and twitchings of the muscles,
and contractions of the limbs, if the antero-lateral columns
are principally involved. When both sets of columns — as is
generally the case — are affected, the troubles of sensibility
and of motility are both present.

If the tumor is situated in the cervical or upper dorsal
region, there is generally tonic contraction of the muscles
of the neck, by which the head is thrown backward, caus-
ing the patient to present the appearance of a person afiect-
ed with the opisthotonos of tetanuos. There are in such a
case usually ocular troubles, such as those previously men-
tioned, and more or less gastric derangement. The symp-
toms, so far as the limbs and viscera are concerned, vary

518 DISEASES OF THE. SPINAL CORD.

in their extent according to the situation of the morbid
growth.

The symptoms of compression are anaesthesia and motor
paralysis. These may or may not be accompanied with
muscular atrophy. Reflex excitability and electro-muscular
contractility are generally at first increased, or at least not
lessened, but, as the pressure increases and the structure of
the cord becomes more disorganized, they are lessened.

Many cases, of what may with Drs. Charcot and Brown-
Sequard be called hemi-paraplegia, are due to spinal tumors.
It often happens that these are small and compress a lateral
half of the cord, leaving the other affected only by the trans-
mitted pressure. A very remarkable case has been report-
ed by Charcot,^ in which the left inferior extremity was
completely paralyzed, while the right was simply weak
without having lost the power of contraction in any of its
muscles. On the other hand, sensibility was greatly les-
sened in the right limb, while it was exalted in the left.
There was paralysis of the bladder, but no atrophy of either
limb. Finally, anasarca and bed-sores appeared, and the
patient gradually sank. On post-mortem examination, a
tumor was found growing from the dura mater on the ante-
rior face of the cord and compressing its left lateral half.
The accompanying woodcuts (Figs. 26 and 27), reduced
from Charcot's lithographic representations, show the situ-
ation and relations of this tumor. Fig. 26 shows the growth
in situ, and Fig. 27 the parts as they appeared when the
tumor was pushed aside so as to allow the cavity to be seen
in which it was lodged.*

Eecollecting the facts that the fibres of the anterior or
motor columns of the cord decussate at the medulla oblon-

' Archives de Physiologic, No. 2, p. 291.

^ This case is quoted at length by Dr. Brown-S6quard in the Lancet of Sep-
tember 25, 1869, p. 429. In previous and subsequent numbers of this journal
Brown-Sequard has contributed much valuable information on the subject of
hemi-paraplegia.

TUMORS OF THE SPINAL CORD.

519

gata, while those of the posterior or sensory columns cross
over soon after they enter the cord from the posterior roots
of the spinal nerves, we can understand why, when the pa-
ralysis of motion is confined to one side, or is greater on that
side, that the lesion is on the corresponding side of the cord,

Fro. 26. Fig. 27.

and that this loss of motility should be accompanied with
anaesthesia of the opposite side of the body.

Under the name of painful paraplegia (paraplegic don-
loureuse), Cruveilhier referred to a form of spinal disease
which has been subsequently described more fully by Char-
cot. This latter author has observed six cases, in all of which

520

DISEASES OF THE SPINAL CORD.

there was cancer of the mammary gland. In three of these
he had the opportunity of making post-mortem examinations,
and discovered carcinoma of a lumbar vertebra in each, to
which the irritation and compression of the cord were dne.
According to him, " the skin, especially during the parox-
ysms of pain, is often very sensitive to the touch. At the
same time walking becomes troublesome, and later the pa-
tient cannot walk without help ; finally, muscular atrophy
ensues, and the patient loses the power to stand."

Simon,* from whom I quote these details, under the head
of " paraplegia dolorosa," describes a case which came
under his own observation, in which, during life, symptoms
similar to those mentioned by Charcot, were noticed, and
in which, after death, a cancerous tumor was found growing
from the first lumbar vertebra and compressing the posterior
columns of the cord. Other lesions were present in the
posterior columns both above and below the tumor; they
were apparently of the nature of sclerosis. Similar cases
have been described by other authors.

Although it is rendered certain that cancerous tumors
of the vertebras may give rise to paraplegia characterized by
great' pain, it must be borne in mind that these symptoms
are not a necessary accompaniment of the lesion, and that
they are met with in other afiections of the cord.

Causes. — Nothing is known relative to the etiology of
intra-spinal tumors beyond the fact that they may result
from the syphilitic, scrofulous, and cancerous diatheses.

Diagnosis. — There are no certain marks by which we can
determine with any great degree of certainty that a tumor
is compressing the spinal cord. We may suspect such to be
tlie case when the motor paralysis is more marked on one
side of the body than the other, and the ansBsthesia exists to
a greater extent on the opposite side. The existence of

1 Berliner Klinische Wochenschrift, Hefte 35 and 36, 1870; also Journal op
Psychological Medicine, January, 1871, p. 125, translation and abstract by Dr.
D. F. Lincoln.

TUMORS OF THE SPINAL CORD.

521

either syphilis, scrofula, or cancer, in connection with spinal
difficulties not clearly referable to some other disease, may
likewise excite the suspicion that a tumor exists.

Prognosis. — This is always unfavorable. It is less so
when a syphilitic origin can be made out. No others re-
cover.

Morbid Anatomy and Pathology. — The most common intra-
spinal morbid growths are those which are developed from
the vertebrae, and they include many syphilitic, scrofulous,
and cancerous tumors. They originate either from the
bones or from the periosteum. Formations resulting from
either of these diatheses may also grow from the meninges
or the substance of the cord.

Parasitic tumors due to either the echinococcus or the
cysticercus may also be developed within the spinal canal.
Their usual seat is in the membranes ; and, according to
OUivier,* the echinococcus is found in the spinal cavity of
women only.

Aneurismal tumors occasionally form in the intra-spinal
arteries, and may compress the cord. Aneurisms of the
thoracic or abdominal aorta may, by pressure, cause absorp-
tion of the vertebrae, and may thus eventually subject the
cord to their influence.

Treatment. — The attempt should always be made, when-
ever the existence of a tumor of the spinal cord is suspected,
to effect its removal by anti-syphilitic treatment, with iodide
of potassium and mercury. The following case will show
the advantages of following this course :

In the summer of 1869 I was requested to visit a gentle-
man who I was informed was paraplegic and subject to
paroxysms of great suffering. On making my examination
I found his limbs contracted, his reflex excitability aug-
mented, and motor paralysis and anaesthesia of both lower
extremities. There were intense pain in the lower dorsal
region, and violent spasms of the sphincter vesicae, alternat-
' Traite des Maladies de la Moelle 6pini&re, Paris, 183*7, t. ii., p. 549.

522

DISEASES OF THE SPINAL CORD.

ing with paralysis of it and the bladder. There were also
paroxysms of severe pain in the head, and occasional attacks
of delirium. He denied any syphilitic infection, but, on ex-
amining his head with my hands, I found a gummy tumor
of the scalp over the right occipital region. Further in-
quiry and examination revealed the existence of a similar
tumor over the left radius. I inferred that there might be
one or more like growths within the spinal canal, and I
administered the iodide of potassium in gradually-increasing
doses, with the bichloride of mercury in doses of the six-
teenth of a grain three times a day. In less than two
months every symptom of disease, except a general weak-
ness, had disappeared. The tumor of the scalp went during
the lirst month ; that of the arm a week later. The iodide
of potassium was carried up to fifty grains three times a
day. This patient continues in good health up to the pres-
ent time. Even if there was not sufficient reason to diag-
nosticate the existence of an intra-spinal syphilitic tumor,
the success of the treatment can scarcely leave a doubt on
the subject.

CHAPTEK X.

SECONDARY DEGENERATIONS OF THE SPINAL CORD.^

It is a well-recognized fact that disease of an organ pro-
motes its atrophy and degeneration. A muscle, which from
any cause is rendered incapable of contracting, becomes
smaller, and its fibrillae undergo conversion into fat. The
same law applies to other organs, and among them the spi-
nal cord. Whatever interrupts the passage of the normal
excitations through its columns causes degeneration. Thus,
if there be a cerebral htemorrhage, preventing the action of
the brain on the muscles, the anterior columns of the cord,
not being stimulated by their accustomed excitation, under-
go the change mentioned. If the cord itself be the seat of
a lesion, or the posterior nerve-roots, and perhaps even the
nerves or muscles, the posterior columns above, no longer
being required to convey impressions to the brain, suffer
atrophy and degeneration. To this alteration, which is not
itself a primary disease, but which is always, in its very na-
ture, consecutive to lesions in superior or inferior parts of
the nervous system, the term secondary degeneration has
been applied.

The fact that the spinal cord is affected by lesions of the
brain was observed by Cruveilhier,* who, however, failed to

'This chapter is mainly a condensation of the admirable memoir on the
same subject, by M. Ch. Bouchard, published in the Archives Gen. de Med.,
1866. This memoir has been translated by Dr. E. R. Hun, of Albany.

^ Anatomic Pathologique, liv. xxxii., p. 15.

524:

DISEASES OF THE SPINAL CORD.

notice any consecutive change in the cord below the decus-
sation of the pyramids.

L. Tiirck was the first specially to inquire into this
important subject, and, in a series of memoirs extending
through the years from 1851 to 1855, he showed that the
cord underwent secondary degeneration, both from lesions
of the brain and of its own substance. Since these me-
moirs, other pathologists, among whom MM. Charcot, Tur-
ner, Rokitansky, Yulpian, Cornil, and Lancereaux, may be
mentioned, reported cases, but no one has investigated the
subject with so much thoroughness as M. Bouchard.

Symptoms. — The most important symptoms referable to
secondary degeneration of the cord from cerebral lesions
are muscular contractions. These are not the contractions
which sometimes exist from the very inception of a haemor-
rhage, for instance, but those which come on at a later
period of the disease, and which, like the first, have gener-
ally been thought the consequence of irritation existing
about the cicatrix. Bouchard, however, shows very clearly
that they are the result of secondary changes taking place
in the spinal cord, and the clinical history of which has pot
hitherto been carefully studied. They are very frequent.
Of thirty-two cases of old hemiplegia analyzed by Bou-
chard, they were present in all but one. From my own
experience I think it is safe to say that it is very rare to
meet with a case of hemiplegia of over a year's duration in
which they do not exist.

In examining a patient sufi*ering from an old hemiplegia,
it is common to find the forearm of the paralyzed side flexed
to some extent on the arm. Frequently, also, the fingers
are bent into the palm of the hand, the hand flexed on the
forearm, and the whole member carried across the front of
the body, and held firmly against it b}' the contraction of
the pectoralis major muscle. In such a case we find the mus-
cles atrophied, hard, and stretched to an extreme degree of
tension. Rectification of the position is, to a great extent,

SECONDARY DEGENERATIONS OF THE SPINAL CORD. 52^

impossible by the voluntary efforts of the patient. He may
be able to accomplish a little motion, and to do still more
by using the sound hand to extend the affected arm ; but, if
the hemiplegia has been of considerable duration, the range
of his motility, with or without assistance, is very small,
and is sometimes nothing. I have found that the electric
contractility of such muscles is diminished in some of their
fibres, unaffected in others, and exalted in others, so that,
when the electrical stimulus is applied, a hard, irregular,
and knotty contraction is obtained.

This condition is much more common in the muscles of
the upper extremity than in those of any other part of the
body. The muscles of the trunk are never involved, and,
unless, as Bouchard appears to think, the muscles of the face
are occasionally affected, the difficulty is entirely confined
to the extremities. Of these, the upper are much more
frequently its seat. Thus, of the thirty-one cases of rigidity
with contraction, studied by Bouchard, the upper extremity
was implicated in all, and the lower but in fourteen. In
none of his cases was the lower extremity affected without
the upper also participating, and he lays this down as an in-
variable occurrence. I have, however, a patient now under
my charge, a gentleman from the West, who five years ago
had an attack of cerebral haemorrhage which rendered him
hemiplegic on the left side. There is not the slightest con-
traction of the muscles of the left upper extremity, but the
toes of the left foot are strongly flexed, and the sole of the
foot turned inward by the contraction of the flexor longus
digitorum, and the tibialis posticus.

In a case also now under my charge, the upper extremity
is not carried across the front of the body, but is drawn
backward by the contraction of the latissimus dorsi.

The period at which these secondary contractions begin
in cases of hemiplegia has been carefully studied by Char-
cot, and he has ascertained that they habitually make their
appearance during the second month. The fingers are usu-

526

DISEASES OF THE SPINAL CORD.

ally the first to be affected from the contraction of tlie flexor
muscles in the forearm. A symptom mentioned by Bou-
chard, as sometimes occurring, a trembling in the arm when
it is raised, I have witnessed several times.

When the cord itself is the seat of primary disease, the
anterior columns below undergo degeneration, and muscles
become permanently contracted. Many cases of distortion
which ensue on sclerosis, tumors, and other lesions, are the
result of this secondary degeneration. M. Charcot is of the
opinion that the epileptiform attacks sometimes met with in
hemiplegics may result from these secondary descending
degenerations affecting the peduncles, the pons, and the
medulla oblongata.

No symptoms referable to ascending secondary degen-
erations— those of the posterior columns — have been recog-
nized.

Causes. — Secondary degeneration of the spinal cord may
result from primary lesions of the cerebral hemispheres, of
the cerebral peduncles, of the pons Varolii, of the medulla
oblongata, of the spinal cord itself, and of the posterior roots
of the spinal nerves. The immediate causes are the loss of
the due supply of arterial blood, and the arrest of nutritive
action from deficient nervous influence.

The Diagnosis calls for no special consideration.

Prognosis. — This is not so unfavorable as might at first
sight be supposed. Bouchard concludes tliat a cure is pos-
sible even in severe cases. In five cases which came under
his observation, and in which there was complete paraplegia
due to the compression of the cord in Pott's disease, com-
plete cures were obtained in four, and a partial cure in the
other. In the four entirely successful cases as regards the
restoration of sensibility, and the power of motion to the
paralyzed limbs, there were contractions. He therefore
concludes that the nerve-fibres of the cord, like those of the
peripheral nerves, may be regenerated.

My own experience is to the same effect. In cases of

SECONDARY DEGENERATIONS OF THE SPINAL CORD. 527

muscular contractions resulting from cerebral hsemorrhage,
and secondary degeneration of the cord, and in like diffi-
culties due to primary lesion of the cord itself, followed by
secondary degenerations, I have several times succeeded in
effecting the complete relaxation of the contracted muscles,
and the entire restoration of sensibility and the power of
motion to the paralyzed limbs.

Morbid Anatomy and Pathology. — Secondary degeneration
is only found in the white substance, the gray being always
unaffected. This might certainly have been expected, owing
to the fact that it is the conducting power of the cord only
that is lessened, and, as this power resides entirely in the
fasciculi of the white substance in the antero-lateral and
posterior columns, it is here that we find the lesions. "When
a fibre belonging to the white substance is injured, either in
the cord or in its intra-cranial prolongations, the secondary
degeneration ensues either above or below the seat of the
primary lesion, but it extends through the entire length of
this portion to its central or peripheral extremity, according
as it involves sensory or motor filaments. To these two
varieties, the terms ascending and descending degeneration
are applied. The affected fibres alone are changed, and the
alteration extends throughout their whole length. But, as
the white fibres are constantly receiving other fibres which
have had no initial injury, the secondary degeneration be-
comes relatively less the greater the distance is from the seat
of the primary lesion.

The morbid condition depends upon three processes:
atheroma of the capillaries and the formation of granular
corpuscles in the degenerated tissue ; the degeneration and
atrophy of a greater or less number of nervous filaments ;
the proliferation of connective tissue which takes the place
of the nerve-tubes. These changes are similar to those
which occur in the several forms of sclerosis, to which at-
tention has already been directed.

Treatment. — Nothing is said by Bouchard relative to the

528

DISEASES OF THE SPINAL CORD.

treatment. I have obtained the best results from the use
of the primary galvanic current to the cord, the same or the
induced current to the muscles, forcible extension and flex-
ion of the contracted limbs, and the internal administration
of nitrate of silver, chloride of barium, and cod-liver oil. It
will generally be found that the opposing muscles are more
or less paralyzed, and that great good may be effected by
stimulating them with the primary or induced currents.
The division of tendons is never necessary, unless for the
rectification of distortions of the toes or fingers. Sometimes
the toes are strongly flexed against the sole of the foot, ren-
dering it almost impossible to walk, from the pain produced
by the dorsal surface being brought in contact with the
ground, and hence obliged to bear the weight of the body.
In such cases the tendons may with propriety be divided,
unless the toes can be kept extended by some convenient
prothetic apparatus.

CHAPTER XI.

T E T AN vs.

Two varieties of tetanus are generally described by sys-
tematic writers — tlie idiopathic and the traumatic ; but, as
they are characterized by similar phenomena, differing
mainly as to their modes of origination and severity of their
symptoms, there would be no advantage in considering
them separately.

S3rinptoms. — The first symptom to make its appearance
in cases of tetanus is a feeling of pain or oppression in the
epigastric region. In the beginning it does not attract
much attention, but, as the disease advances, it becomes
exceedingly severe, and adds greatly to the discomfort of
the patient.

Soon after the occurrence of this pain, uneasiness is gen-
erally observed about the throat. This is, perhaps, no more
than a sense of stifi'ness of the muscles concerned in deglu-
tition, but it is not long before swallowing is impeded to a
considerable extent. With these symptoms there are or-
dinarily mental and physical depression, sensations of chil-
liness, and a general feeling of malaise.

The foregoing constitute a prodromatic or formative
stage, which may last a few hours or several days, and
which is occasionally overlooked when the disease is in-
tense and rapid in character.

In the next stage the epigastric pain is still a prominent
symptom. It is seated just below the sternum, and gener-
ally extends backward to the spinal column. It appears to
34

530

DISEASES OF THE SPINAL CORD.

be due to -spasm of the diaphragm, so that this muscle is
among the first, if not the verj first, to be affected in the
vast majority of cases. The difficulty of swallowing in-
creases, and then the muscles of the jaws become contracted,
constituting the condition known as trismus or lockjaw.
At first there is only stiffness of these muscles with those
of the neck, but gradually they become rigid, and the pa-
tient experiences difficulty, if not impossibility, in opening
the mouth. The facial muscles do not escape, and an ex-
pression like the risus sardonicus is produced from the re-
traction of the angles of the mouth, the elevation of the
alse nasi, and the expansion of the nostrils. At the same
time the eyes are staring, the brows corrugated, and the
countenance anxious or wearied in appearance.

Sometimes gradually, at others suddenly, the morbid ac-
tion extends to other muscles. Generally it passes to those
of the neck, the back, and the loins, causing violent con-
traction, and bending the body backward. This state is
called opisthotonos. The contraction of the powerful
muscles referred to is so great as to cause the body to as-
sume the form of an arch, the head being thrown far back,
the abdomen protruded, and. thus, if the patient were placed
on his back, only the occiput and heels would touch the bed.
Opisthotonos is the usual variety of spasm.

Two other forms are occasionally met with. In one of
these — emprosthotonos — the body is bent forward from the
contraction of the thoracic, abdominal, and pelvic muscles.
In the other — pleurosthotonos — it is bent laterally. This
latter may be met with in opisthotonos, owing to the
muscles on one side being more strongly affected than on
the other. Both emprosthotonos and pleurosthotonos are
rare. Of very many cases of tetanus that have been un-
der my observation, I have only seen the former four and
the latter three times. The spasms characteristic of the
disease are tonic ; but, though they do not entirely relax,
they are marked by more or less exacerbation, according to

TETANUS. 53;!^

the severity of the attack, and the care taken of the patient.
Any cause calculated to excite reflex action will induce an
accession. Thus the contact of the bedclothes with the
body — the legs especially— the touch of the hand, the forci-
ble shutting of a door, the rumbling of carnages in the
street, even the blowing of a breath of air on the skin, may
produce an aggravation of the spasm. Even without any
apparent excitation these fits occur. They are marked bv
great pain, and may be so violent as to break the teeth, and
the bones of the legs, and tear the large muscles of the thighs.
During their continuance, and often when they are not pres-
ent, the pain at the pit of the stomach becomes unendurable,
and the patient may lose consciousness through its intensity.
I have several times seen this event occur.

The tonic rigidity of the muscles of respiration in-
duces difiiculty of breathing, and the same result may
ensue from spasmodic closure of the glottis. Death has
frequently taken place suddenly from one or other of these
causes.

With all this muscular excitement and mental disturb-
ance there is rarely any fever. Tlie skin is hot, and the
thermometer often ranges from 105° to 110° Fahr., but the
pulse is frequently small and weak.

Owing to the difficulty of swallowing, the patient suffers
from hunger and thirst, and thus the powers of the system
are still further reduced. The bowels are always obstinate-
ly constipated.

Wakefulness is generally present from the first. When
the patient does sleep, it usually happens that the muscles
are relaxed, to be again suddenly affected with spasm as soon
as he awakes.

The mind is clear throughout, even in the most severe
cases. When loss of consciousness occurs from extreme
pain, it is from syncope, and not from any implication of
the brain in the essential nature of the disease. Death usu-
ally takes place by apnoea. It may, however, result from

532

DISEASES OF THE SPINAL CORD.

exhaustion, and, according to some authorities, from the
spasmodic action attacking the heart.

The duration of the disease is very variable. The short-
est case on record is one observed by Prof. Robinson, of
Edinburgh. The patient, a negro waiter, cut his finger
with a piece of broken china. He was immediately seized
with tetanus, and died within fifteen minutes. Mr. Poland
quotes a case in which death took place in five hours ; in a
case cited by Lepelletier in a few hours ; in one by Dr.
Jackson in twelve ; in one by Dr. Leith in eighteen ; and
in one observed by Mr. Curling in nineteen.*

The shortest duration in any case I have witnessed was
twenty-six hours, though I believe there were several much
shorter, which occurred during the recent war in this coun-
try.

The average period of duration in fatal cases is from the
third to the fifth day. Instances in which it has been pro-
longed far beyond this limit are not uncommon. Hennen'
reports a case in which it lasted six weeks, and then the
patient died of another disease. He reports another case in
which it lasted seven weeks, and ended in recovery. I have
seen three cases in which it extended to the fifth week.

The period which elapses between the reception of the
cause and the beginning of the symptoms is also subject to
great variation. In a case already cited it was only fifteen
minutes ; in another, quoted from Dr. Randolph by Reeves,'
the spasms ensued immediately after the patient was stung
by a bee ; and in another, which occurred in his own ex-
perience they came on in a sensitive female immediately after
running a needle into her finger. There is doubt, however,
as to such cases really being tetanus. In the last one cited it

' All the above instances are quoted from Reeves's Diseases of the Spinal
Cord and its Membranes, London, 1858, p. 38Y, ct seq.

* Observations on some Important Points in the Practice of Military Sur-
gery, etc. Edinburgh, 1818, p. 263.

3 Op. cit., p. 377.

TETANUS.

533

is stated that " the body and extremities were rigid, mouth
closed, and the jaws fixed, the eyes the same. At short in-
tervals the whole body was aflfected with convulsive shocks ;
the administration of a dose of chloroform removed them,
but the back and neck remained rigid for three days."
This attack was probably a manifestation of hysteria. In
eighty-one cases collected by Mr. Curling, the disease began
between the fourth and fourteenth days, both inclusive, and
in nineteen on the tenth day. The following table from
Eeeves shows the period of the occurrence of the disease in
three hundred and forty-three cases :

Within six, twelve, eighteen, or twenty-four hours. . . 13

From 1 to 2 days. 13

" 3 to 5 " [ [ [ 37

" 6 to 8 " 94

" 9 to 12 " 77

" 12 to 14 " 52

" 15 to 17 « ][ 25

" 18 to 20 " 9

" 21 to 28 " 9

" 24 to 26 " 6

" 27 to 29 " 9

" 30 to 32 " 1

843

Causes. — The most common cause of tetanus is bodily
injury of any kind, from the slightest to the most severe,
and of any part of the body, although wounds of some
parts, as of the thumb and great toe, are more apt to be fol-
lowed by the disease than those of other regions. It has
been known to result from the bite of a tame sparrow, from
the sticking of a small fish-bone in the pharynx, from a
seton in the thorax, from the stroke of a cane across the
back of the neck, from the blow of a whip-lash, from frac-
tured bones, and from every other imaginable wound or in-
jury. In a case under my charge in this city, it was caused
by a splinter of wood slightly scratching the palm of the

534

DISEASES or THE SPINAL CORD.

hand, in another a slight punctured wound of the foot pro-
duced it.

Next in frequency to wounds, tetanus is induced by-
exposure to cold and damp. This is the exciting cause in
the great majority of cases of idiopathic tetanus, and it in-

^ creases liability in those who have suffered from wounds.

' It was not uncommon, during the recent war, for the num-
ber of cases of tetanus to be very much increased immedi-
ately after a sudden change of the weather from dry and

^mild to wet and cold.

It has also apparently been caused by worms, by abor-
tion and labor, and by diseases of the womb. Terror has
the reputation of having induced tetanus in one case report-
ed by Dr. Willan, and in others observed by Hennen.

In the form occurring in very young children, and known
as trismus nascentium, it appears to be induced by inatten-
tion to the cut umbilical cord.

The tendency to tetanus, especially among soldiers and
others who have been wounded, is increased by poor diet,
confinement in ill-ventilated hospitals, inattention to clean-
liness, and neglect to give proper care to the wounds they
may have received.

Diagnosis. — The only affections with which tetanus is
liable to be confounded, by any but the most ignorant, are
the hysterical simulated affection, and the condition in-
duced by poisoning with strychnia and other substances of
its class.

That hysteria can simulate tetanus, as well as almost all
other diseases, we have abundant evidence. A case has
already been referred to in this chapter which was evidently
hysterical, and several others have come under my observa-
tion. A lady now under my charge has repeated attacks of
hysterical spasms, during which her jaws are tightly closed,
she is unable to swallow, and her body is bent backward so
as to assume the position of opisthotonos.

Such seizures are readily distinguished from tetanus by

TETANUS.

535

the facts that they are unaccompanied by pain or real dis-
tress, are of very transient duration, and are accompanied
by other manifestations of hysteria.

From the artificial tetanus caused by strychnia, the diag-
nosis is more difficult ; for, so far as the more obvious symp-
toms go, there is such a great similarity that even the most
skilful diagnosticians might be, for a time, undecided. It
is well known that strychnia is not unfrequently used for
the purpose of committing murder or suicide, and it is pos-
sible so to employ it for either of these purposes as to cause
its effects to extend over a long period of time, and thus to
add to the difficulties attending the discrimination. Even
in such a case, however, the diagnosis can be made if due
care and a thorough inquiry into the history of the case be
made.

In the first place, the tetanus of strychnia always shows
itself in the lower extremities before trismus ensues. The
legs are stretched widely apart, and the hands are generally
involved. In natural tetanus, trismus precedes spasm in
the extremities ; indeed, the lower extremities are rarely
affected to any great extent. The arms generally escape
altogether.

The epigastric pain, which constitutes so prominent a
feature of true tetanus, is not present in the toxic variety.
I have witnessed three cases of poisoning by strychnia, and
this pain was not complained of in either of them.

In the tetanus of strychnia, the symptoms are developed
with great rapidity, and death takes place generally within
a half an hour, although life may be prolonged, in excep-
tional cases, somewhat beyond this peried. In true tetanus
it is very rarely the case that death takes place within twelve
hours, and ordinarily not till several days have elapsed.

In those cases of poisoning by strychnia in which thq
doses have been small, and administered at comparatively ;
long intervals, the symptoms are mitigated in violence, and
consequently one of the distinguishing features of the two

636

DISEASES OF THE SPINAL CORD.

affections is lost. Still, the general character and sequence
of the phenomenon are the same, and it is not probable that
careful observation and inquiry will fail to elicit the true
nature of the case.

Prognosis. — The longer the time that has elapsed between
the reception of the injury or subjection to other cause, the
greater is the probability of a favorable termination. When
the paroxysms are slight, and the intervals between them
long, the prognosis is also more favorable. The duration
of the disease is likewise an important element in the prog-
nosis ; and, when it has lasted over a week, death does not
often take place. Cases are, however, on record in which a
fatal result has supervened after the affection has existed for
several weeks.

Tetanus is, nevertheless, one of the most fatal of mala-
dies. Dr. O'Beirne ^ witnessed two hundred cases without
a single recovery. Hennen" never saw a case of acute
symptomatic tetanus recover. McLeod ' has collected and
analyzed twenty-three cases which occurred in the British
army in the Crimea, of which but two recovered. Demme*
refers to eighty-six cases in the hospitals in Italy during
the campaign of 1859, of which six were cured; and
Hamilton'* has observed eight cases, of which three re-
covered.

Nine cases have been under my immediate care, of
which there were three recoveries. Of the many cases
which I observed in the course of my inspections of camps
and hospitals in the army during the recent war, I do not
know how many terminated favorably. I am disposed,
however, to believe that the number was not great. Ham-
ilton states that his information leads him to think that, of

1 Dublin Hospital Reports, vol. iii., pp. 343, 378. * Op. cit., p. 262.

' Notes on the Surgery of the War in the Crimea, London, 1858, p. 153, et
seq. Also table, p. 439.

* Militar-Chirurgische Studien, Wurzburg, 1861.

^ A Treatise on Military Surgery and Hygiene, New York, 1866, p. 596.

TETANUS.

537

one hundred and fifty cases which occurred during the war,
the recoveries were few.

Morbid Anatomy and Pathology.— The results ofpost-mor-
tern examination of patients who have died of tetanus are
very unsatisfactory. Eokitansky/ in chronic cases, has
found a proliferation of connective tissue in the spinal cord.
Wedl,' in one case, discovered increased redness of a por-
tion of the spinal cord. Curling' declares that serous effu-
sion with increased vascularity is generally observed in the
membranes investing the medulla spinalis, and also a turgid
state of the blood-vessels above the origin of the nerves ;
and Lockhart Clarke' regards the constant lesion as con-
sisting of a granular degeneration of the cells of the
cord.

On the other hand, it often happens, especially in
very rapid cases, that nothing is found which can fairly be
regarded as constituting the essential feature of the disease.
Billroth' affirms that his examinations of the spine and
nerves, in cases of tetanus, have thus far given only nega-
tive results, and this is in accordance with the observations
of the great majority of pathologists. While, therefore,
there appears to be no doubt that the disorder is dependent
upon some lesion of the spinal cord, and probably of the
gray matter, our examinations have not as yet enabled us
to determine the nature of the morbid process.

It is contended by some authors that tetanus, like hydro-
phobia, is due to blood-poisoning. The fact, that a condition,
so nearly resembling it as to be with difficulty diagnosti-
cated fz'om it, may be caused by the injection of strychnia
into the blood, appears to favor this view. However this

' Beitrage zur Pathologic des Tetanus. Virchow's Archiv, t. xxvi., 1862.
2 Rudiments of Pathological Histology. Sydenham Society Translation.
London, 1855, p. 276.

^ A Treatise on Tetanus, etc., London, 1836.

* Lancet, 1864, and Medical Times and Gazette, 1865.

' General Surgical Pathology and Therapeutics, in Fifty Lectures. Hack-
ley's Translation. New York : D. Appleton & Co., 1871, p. 353.

538

DISEASES OF THE SPINAL CORD.

may be, the character of the symptoms indicates the spinal
cord to be the seat of the disease.

The spinal cord is both an organ for the generation of
nerve-force, and for conducting impressions to and from the
brain. In tetanus it is this first-named function which is
deranged, and this is shown by the great exaltation of reflex
excitability which exists. Every thing capable of causing a
reflex movement of the slightest kind, and even excitations
which in health would be altogether unperceived by the
cord, augment its intrinsic action to a great extent where
tetanus exists.

Kow, we are able to produce a similar increase of reflex
action by strychnia ; and, in those cases of disease in which
the amount of blood in the cord is increased, very small
quantities of strychnia produce the characteristic phenomena
of stifiiiess in certain muscles, and of augmented reflex ex-
citability. The condition is aggravated by the medicine ;
and, if we had no other facts to support the theory, we
should be warranted in concluding that, in cases of strych-
nia-poisoning, the amount of blood in the cord and the
excitability of the organ are both increased. From a con-
sideration of all the points bearing on the subject, we are
warranted in concluding that tetanus essentially consists in
a morbid exaltation of the functions of the spinal cord as a
nerve-centre.

Bernard * has investigated this matter with his usual ex-
actness. He says :

" Strychnia produces convulsions by exaggerating the
sensibility of certain parts ; it also causes reflex movements.
"We have seen that the point of departure is in the sensitive
system ; for, where the posterior roots of the nerves are cut,
the animal dies without convulsions,"

An experiment performed by myself and my friend and

' Le9ons sur les Effets des Substances toxiques et medicamenteuses, Paris,
1857, p. 386.

TETANUS.

539

collaborator, Dr. S. "Weir Mitcliell/ shows that the action
of strychnia is to destroy the nervous excitability from the
centre to the periphery. Its influence, therefore, must first
be exerted on the spinal cord.

" Under the skin of a large frog, whose left sciatic nerve
was previously divided, a few drops of a strong solution of
strychnia were introduced. Tetanic spasms ensued in two
minutes. After forty-five minutes the nerves were irritated
by galvanism. That of the left side, which had been cut,
responded energetically, while no motions could be pro-
duced through the uncut nerve. The former remained ex-
citable for two hours later."

Bernard ' asserts that the action of strychnia extends no
farther than the spinal cord ; and any one who has seen a
frog under the influence of this substance cannot have failed
to notice that all the symptoms indicate exalted spinal ac-
tion.

We are therefore led by observation and experiment to
the conclusion that tetanus is seated in the spinal cord, and
that, although we cannot at present affirm an identity of
lesions, in each case we shall probably eventually be able to
define them with as much accuracy as we do those of other
spinal diseases which a few years since were equally ob-
scure.

Treatment. — There is scarcely a sedative or stimulant
remedy in the pharmacopoeia which has not been employed
and recommended in tetanus. Aconite, ether, belladonna,
chloroform, cannabis Indica, conium, opium, tobacco, Cal-
abar bean, ice, counter-irritants, alcohol, and many other
substances, have been used, and cases reported which have
apparently recovered under their administration. Then, of
surgical means, excision of the injured nerve and amputa-

' Experimental Researches relative to Corroval and Vao ; two new Varie-
ties of Woorara, the South American Arrow-Poison. American Journal of the
Medical Sciences, July, 1859. Also Physiological Memoirs, Philadelphia, 1863,
p. 181, etseq. 2 Qp. cit., p. 359.

640

DISEASES OF THE SPINAL CORD.

tion of the wounded member have also been recommended,
but are not, I believe, practised now. Latterly the bromide
of potassium and hydrate of chloral have been employed
with favorable results.

A case in which the latter agent was successfully used
in tetanus is reported by Dr. Wirth,' of Columbus, Ohio.
In about a month the patient took nine ounces and two
drachms, in doses of from thirty to forty grains, at times as
often as every one and a half hour. In this case opium in
large doses had been administered without effect. A num-
ber of other cases in which chloral was administered are
cited in the same number of the New Toek Medical Jour-
nal in which Dr. "Wirth's case appears, in several of which
it was successful.

A very thorough analysis by my friend Dr. D. W. Yan-
dell,^ of Louisville, of an unpublished report on tetanus, by
Dr. E. O. Cowling, embraces so much valuable information
on the subject that I quote the summary entire. The term
acute is applied to tetanus occurring within nine days of the
injury, and chronic to cases ensuing after nine days :

" Calabar hean was given in thirty-nine cases, with
thirty-nine per cent, of recoveries. Of these reported cures,
but one was of acute tetanus ; five others were in cases
which recovered before the expiration of fourteen days.
Per contra, there were ten deaths from chronic tetanus.

" Indian hemp used in twenty -five cases, with sixty-
four per cent, of recoveries, of which three cases were
acute, and six recovered before the symptoms lasted four-
teen days.

" Chloroform relieved seventy per cent, of thirty-five
cases, nine of which were acute, and eight recovered before
fourteen days. Three chronic cases died, and two after
symptoms lasted fourteen days.

" Ether. — Sixty per cent, of fifteen cases recovered ; five

1 New York Medical Journal, November, 1870, p. 419.
^ American Practitioner, September, 1870, p. 152.

TETANUS.

541

acute ; seven inside of fourteen days. One chronic case
died.

" Opium. — Fifty-seven per cent, of one hundred and
sixty-five cases recovered ; twenty-two acute ; twenty-nine
before the fourteenth day. Twenty-six chronic cases were
lost, and four after the disease had continued fourteen days.

" Tobacco relieved fifty per cent, of forty-one cases ; six
acute ; six before fourteen days of the disease. Four chronic
cases died, and one after fourteen days.

" Quinine. — Seventy-three per cent, of fifteen cases re-
covered ; one acute ; three before fourteen days. Three
chronic cases ended fatally, and one after fourteen days'
duration.

" Aconite. — Eight per cent, of fourteen cases recovered ;
none acute ; none recovered before fourteen days. Death
in one chronic case.

" Stimulants. — Eighty per cent, of thirty-three cases re-
covered ; four acute ; six within fourteen days. Six chronic
cases died, and three after fourteen days.

"Jfe/'ci^ry.— Fifty-seven per cent, of seventy-five cases
got well ; twelve before fourteen days. Seventeen chronic
cases were lost, and two after fourteen days.

" Bleeding. — Fifty- five per cent, of fifty-eight cases re-
covered ; nine acute ; ten before the fourteenth day. Seven
chronic cases were lost, and two after fourteen days.

" Cold Affusion. — Seventy-three per cent, of eleven cases
recovered ; three acute ; three before fourteen days. Two
chronic cases died.

'■'■Ice-lags. — Seventy-seven per cent, of nine cases recov-
ered ; one acute ; two in less than fourteen days.

'■'•Amputation. — Sixty per cent, of seventeen cases re-
covered ; four acute ; four in less than fourteen days. Three
chronic cases died, and one after fourteen days.

" Division of nerve relieved seventy-five per cent, of
three cases ; one acute ; one before the fourteenth day.
One chronic case died.

542

DISEASES OF THE SPINAL CORD.

" Purgatives. — Sixty-six per cent, of seventy-four cases
recovered ; thirteen acute ; twelve before fourteen days.
Ten chronic cases died, and three after fourteen days.

" Turpentine relieved seventy per cent, of sixteen cases ;
six acute ; four before fourteen days. Five chronic cases
died, and two after fourteen days."

Among the conclusions arrived at by Dr. Tandell from
these data are, that "recoveries from traumatic tetanus
have been usually in cases in which the disease occurs sub-
sequent to nine days after the injury ; that when the symp-
toms last fourteen days recovery is the rule, and death the
exception, apparently independent of the treatment ; that
chloroform, up to this time, has yielded the largest per cent-
age of cures in acute tetanus ; that the true test of a remedy
for tetanus is its influence on the history of the disease :
does it cure cases in which the disease has set in previous to
the ninth day ? does it fail in cases whose duration exceeds
fourteen days ? and that no agent, tried by these tests, has
yet established its claims as a true remedy for tetanus."

It is, perhaps, scarcely necessary to say that I fully ac-
cord with these opinions.

Judging from its effects upon the spinal cord, it was sup-
posed by Mr. Morgan that woorara injected into the blood
might prove efiicacious in tetanus. Experience, however,
has not confirmed this view ; and the researches of Dr. Cow-
ling show that it is one of the most inefficient of remedies.

In a case which was under my charge ten years ago,
when I was one of the surgeons of the Baltimore Infirmary,
I injected corroval — a remedy which the investigations of
Dr. Mitchell and myself had proved to be antagonistic to
strychnia — into the blood. The patient, a colored boy, be-
came affected with tetanus two days after his arm had been
amputated by my friend and colleague Prof. Nathan K.
Smith. Cannabis Indica, morphia, and chloroform, had been
used without effect, when at my request Prof. Smith turned
the case over to me, in order that corroval might be admin-

TETANUS.

543

istered. Two drops of a strong solution of the substance in
water were injected into the cellular tissue of the forearm.
At the time the pulse was 160, and the respirations about
75. There was very decided opisthotonos. In three min-
utes the pulse had fallen to 152. Two more drops were
then injected, and tlie pulse fell to 144. As it soon rose
again, two more drops were injected, when it fell to 132,
and the respirations to 64. The spasms still continu-
ing, two more drops were injected. In five minutes the
pulse began to decline rapidly, and in ten minutes had fallen
to 90. At this time the patient had a violent tetanic spasm,
and during its continuance the pulse became intermittent.
It then rapidly went down to 40, then to 30, and during a
violent spasm the patient died. From this record it will be
seen that ^t no time did the corroval exercise the least effect
over the disease.'

As I have stated, three successful cases have occurred in
my practice. One of these I saw in consultation with Dr.
J. Lewis Smith, of this city. It was traumatic, and had en-
sued two weeks after a wound of the foot by a nail. The
patient was treated by cannabis Indica, and the persistent
application of ice to the spine. The spasms were greatly
lessened in force and frequency, and recovery took place
within two weeks. Another, which was also traumatic and
acute— that is, making its appearance within nine days after
the injury — was treated according to the same plan, and re-
covered in sixteen days, though the jaw^s remained stiff for
several weeks afterward. The wound was caused by an ice-
pick being accidentally thrust through the hand. The third
case was that of an eminent musician of this city, who,
while drilling with the regiment to which he belonged, in-
jured his thumb with a splinter from the stock of his rifle.
The first evidence of tetanus appeared on the twelfth day.

* Traumatic Tetanus. Inoculation with Corroval. Death. By Edward Mil-
hoUand, M. D., Resident Physician at the Baltimore Infirmary. In Maryland and
Virginia Medical Journal, January, 1861, p. 13.

544

DISEASES OF THE SPINAL CORD.

The attack was not very severe. I administered the extract
of cannabis Indica (Squires's) in doses of half a grain every
two hours, and kept up the application of ice to the spine
continuously for six days. There were several violent
spasms during this period, and the opisthotonos was well
marked. At the end of a week the cannabis Indica was
omitted for a day, but, the spasms becoming more frequent
and severe, it was resumed as before, and continued with
tolerable regularity for ten days longer. During this period
there were but two spasms, and the opisthotonos became
less. It was then gradually diminished, and on the twenty-
fifth day was left off altogether, the patient being convales-
cent.

I am disposed to think that, whatever internal medication
be adopted, the application of ice to the spine is a measure
which should always form a feature of the treatment.

SECTION III.

OEEEBEO-SPmAL DISEASES.

CHAPTEE I.

HYD BO FHOBIA.

Although there are objections to the name employed to
designate the terrible disease I now propose to consider, the
same is true of all other terms which have been applied to
it, and the present has the advantage of being well known.
So long as we are obliged, through ignorance of pathology
and morbid anatomy, to use a nomenclature based on symp-
toms, we must expect to be inexact. The name hydropho-
bia is as old as Galen, and still retains its preeminence, not-
withstanding the fact that the symptom on which it is based
is sometimes absent.

Symptoms. — Beginning with the reception of the injury
by which the body has been inoculated, we find that it heals
in the ordinary way, and that there are no immediate signs
of infection. At a period which varies greatly in different
cases, pain or a sensation of uneasiness is usually experienced
at the seat of the wound. Thi^, however, is rarely of such
intensity as to cause suffering, and probably would generally
be overlooked or disregarded but for the apprehension which
the patient has, and which directs his attention to every sen-
sation which can be attributed to the wound. But there
35

546

CEREBRO-SPINAL DISEASES.

may be absolutely no pain or uneasiness other than such as
are met with in all wounds till the phenomena of the affec-
tion are manifested. The period between the reception of
the injury and the beginning of the symptoms of hydropho-
bia is known as the stage of incubation.

The duration of this stage is variable. It is rarely short-
er than a month, and probably never longer than two years.
Instances are on record, however, in which the disease has
been developed within ten days, and others, about which,
however, there is much doubt, in which the latent period has
reached to ten years and longer. The vast majority of cases
occur within seven months after the reception of the wound.
In four cases which have been under my observation, the
period of incubation varied from sixty-two days to four
months and a half.

During this period of incubation there are not often any
indications of what is going to take place except in those
cases in which there are abnormal sensations in the cicatrix
or its neighborhood. Sometimes there are depression of
spirits, anxiety, and derangement of the digestive functions,
but these symptoms may fairly be attributed to the peculiar
circumstances of the case, aside from any toxic influence
due to infection.

The first symptoms which generally appear are directly
connected with the cicatrix, which, if it has previously been
free from abnormal appearances and sensations, now be-
comes subject to both. But there is no constancy even in
these phenomena. They were altogether absent in one of
my cases, and very slightly manifested in one other, if they
were present at all. In this case, which I saw in consulta-
tion with Dr. S. G. Cook,* of this city, the patient, after
other symptoms had appeared, occasionally clutched the
place where he had been bitten, but denied, on being asked,
that there was any pain at the spot.

* A case of Hydrophobia. Journal of Psychological Medicine, January,
1810, p. 80.

HYDROPHOBIA.

547

But, tliougli there may be no symptoms of swelling, red-
ness, or pain about the cicatrix, there are abnormal sensa-
tions in the nerves which radiate from it. Thus, if the in-
jury has been in the leg, pains are felt along the courses of
the sciatic and crural nerves ; if in the hand, similar sensa-
tions are experienced in the radial, ulnar, median, and
other nerves of the upper extremity. Occasionally the pain
is felt in the epigastric region, and in any situation is ordi-
narily accompanied by headache. At about the same time
the respiration becomes sighing and irregular, there is a feel-
ing of oppression or constriction in the chest, the pulse loses
its force and uniformity, and there is an indeiinable sense of
anxiety. The sleep is scarcely ever natural. Either there
is insomnia or drowsiness, and sleep, when obtained, is dis-
turbed by frightful dreams, and is unrefreshing. The bowels
are constipated, the skin is dry, and there are alternate chills
and flushes of heat. The duration of this stage is from two
to four days.

And then the period of full development begins ; char-
acterized, at first, by an increase in the symptoms just men-
tioned, and subsequently by the appearance of others not
previously present. A peculiar sense of uneasiness is felt
at the epigastrium, and a pain and constriction of the throat,
which add greatly to the distress. The tongue becomes stiff
and painful, and articulation is thereby rendered indistinct;
the respiration increases in irregularity, and becomes noisy
and oppressed ; the rigidity of the muscles of the throat
prevents or impedes deglutition, and the patient dreads at-
tempting to swallow, from the experience he soon acquires
that his efforts in this direction are attended with pain and
spasm, which greatly increase his sufferings. Sometimes
the convulsion of the pharyngeal muscles is so great that
substances are thrown with great force out of the mouth.
This was the case in two of the instances I witnessed. At
the same time the spasm extends to other parts of the body,
and occasionally becomes general. It is accompanied by

548

CEREBRO-SPINAL DISEASES.

pain in tlie epigastrium, and sometimes in the spine. Solids
are swallowed with much more ease than liquids. Indeed,
so great is the difference that the patient cannot even enter-
tain the idea of swallowing any fluid without being thrown
into spasms. The sound of water splashing or trickling, the
sight of it, the thought of it, and even an impression re-
motely connected with water, such as that produced by the
reflection of rays of sunlight on the face by a mirror, will
bring on a paroxysm of convulsions. "With the spasm
there are sobbings, trembling, and then a condition of ex-
haustion, during which the patient is bathed in perspira-
tion.

The following day the phenomena are still more strongly
marked. The, mouth is dry and parched, and yet the pa-
tient dare not attempt to quench his thirst ; vomiting ensues,
the pulse becomes rapid and small, the pain in the pit of
the stomach still increases, the headache is intense, and the
countenance expresses terror, anxiety, and suifering. The
pain in the spine augments and extends to the muscles of
the neck and abdomen. The secretions of the mouth are
altered, and the saliva is mixed with a frothy, tenacious mu-
cus, which the patient is constantly attempting to eject, but
which collects as fast as he can spit it out. The mouth and
fauces are dry and painful, articulation is almost impossible,
and every attempt to relieve the distress by a few drops of
water induces a return of the spasms and convulsions. Fi-
nally every reflex excitation reaches the muscles of the
throat ; the contact of the bedclothes, the jarring of the
bed by persons walking in the room, the rustling of window-
curtains — any thing capable of acting on the hearing, the
eyesight, or the touch, may cause the spasms.

As the disease advances, all the symptoms increase in
violence, and still others make their appearance. The urine
an^ faeces are often passed involuntarily, the skin becomes
exquisitely sensitive, the body is in a constant state of agi-
tation and tremor, alternating with spasms, and the tough.

HYDROPHOBIA.

549

stringy, tenacious mucus collects in the throat and impedes
respiration.

Thus far the mental symptoms have scarcely been con-
sidered, but they are present almost from the first. Indeed,
they may be among the very first indications of disorder.
They consist of emotional disturbances of various kinds, and
sometimes radical changes of character and disposition.

It has been alleged by some authors that the dreams, at
a very early period after inoculation, are connected with
the animal giving the wound. I have never met with this
symptom, but in the case previously cited, and which I saw
twice in consultation, a circumstance still more remark a-
able is related by Dr. Cook. The patient, a child three
years old, was bitten by a bitch in heat on or about August
20, 1870. On November 15th the mother noticed that he
slept badly ; on the 16th, among other manifestations, he
"was cranky all day." On the lYth he was seen by Dr.
Cook.'

" On entering the room," says the doctor, in his report
of the case, " and seeing several children, and not noticing
any thing wrong with any of them, I very naturally in-
quired which was the patient. I was pointed to a little boy
sitting at a table in a high chair. On approaching him, he
turned his face toward me, revealing the most peculiar-look-
ing eyes I have ever seen. They were not like those seen
in persons sufiering from delirium in prolonged fevers, nor
yet like those we see in the second stage of cerebral menin-
gitis, although somewhat resembling both of these condi-
tions, but more like the eyes of a person in a fit of violent
anger, slightly combined with a feeling of fear.

" When I reached out my hand to touch his, he shrank
from me as from a blow, at the same time 'making a desper-
ate efibrt to catch his breath, precisely as a naked person
might if a pail of cold water was unexpectedly poured over
him. This I understood to be a laryngeal spasm. It was

' Op. cit., p. 81.

550

CEREBKO-SPINAL DISEASES.

very brief, lasting but the fraction of a minute, probably
not more than ten seconds. I took a seat at a little distance
from him, where I could see his every motion, and regarded
him attentively for a long time.

" He seemed an unusually intelligent child, for one of his
age, speaking very distinctly with a clear, ringing voice,
which his parents informed me was a little unnatural, as it
' seemed strained.' He had at times a disposition to stam-
mer, which was also unnatural. For one hour after my ob-
servation commenced he talked almost incessantly of dogs,
and repeated very few sentences a second time. He seemed
familiar with all the most common breeds, relating some
anecdote of the bull-dog, the mastiff, the bird-dog, the span-
iel, the coach-dog, and the poodle.

" Connected with all his narratives was a tragic or gloomy
termination. The mastiff, after carrying him an incredible
distance about the city, finally disappeared through a bot-
tomless hole in the street, he only escaping a similar fate by
suddenly dismounting. The bull-dog, after bringing for his
admiration and pleasure a great variety of puppies, sudden-
ly turned cannibal, and swallowed the whole lot. The span-
iel, after having been his playmate for a very long time,
finally took it into his head one day to get on to a coffin
that was being carried through the streets, and ride away
to reappear no more."

There were no other evidences of disordered mental ac-
tion in this child, and he died, perfectly conscious to the
last.

Usually, however, this is not the case, and various mor-
bid desires are entertained by the patient. Thus, in a case
which I saw in this city in 1865, there was an impulse to
strike those near, and an intense dislike of certain per-
sons who had always been intimate friends of the patient.
In both the other cases tliere were paroxysms of previous
delirium, during which the sufferers bit and struck at all
within their reach, and of which hallucinations and delu-

HYDROPHOBIA.

551

sions constituted marked features. In the case of tlie boy
just cited, the stories of dogs which he rehxted were evi-
dently delusions which he accepted as realities.

Death usually takes place on the third day after the ac-
cession of the symptoms indicating the full development of
the disease. The chief of these is laryngeal spasm. A fatal
termination is rarely delayed till after the third day, though
cases are not uncommon in which it has ensued on the lirst
or second day. In all the cases, except one, which have been
under my observation, the third was the fatal day. In Dr.
Cook's, the latest I have seen, the disease may be considered
as having been fairly developed on the 17th of November,
the first day in which any spasm of the throat was witnessed.
Death resulted on the evening of the 18th.

Generally death takes place during a spasm. This was
the result in three of my cases. In the other — the latest —
the child died quietly. In the former condition apnoea is
probably the immediate cause of death ; in the latter, ex-
haustion. In all cases, the powers of life, from the violent
convulsions, the loss of sleep, and the deprivation of food
and drink, are drained away to the utmost.

Causes, — It has generally been supposed that hydropho-
bia has but one source in the human subject, and that is, in-
oculation by the saliva of an animal affected with rabies.
It cannot be communicated to one individual by the saliva
of another affected with hydrophobia, although there is no
doubt that, under certain circumstances, the saliva of man,
as well as the milk and other secretions, may become poi-
sonous. Neither can dogs or other animals be infected by
inoculation with the saliva of a hydrophobic man. Ma-
gendie's ' experiment, the only one of the kind which has
ever succeeded, is of exceedingly doubtful import, as hydro-
phobia was prevailing among dogs at the time, and the ani-
mal may have been previously bitten.

1 Dictionnaire des Sciences Med. Art. Rage, t. 47, p. 46. Also Journal de
Physiologie, t. i., p. 47.

552

CEREBRO-SPINAL DISEASES.

But it is very probable that the saliva of healthy ani-
mals, the dog especially, is capable of producing hydropho-
bia in man and other animals. A case of the kind is
recorded in Huf eland'' s Journal of December, 1839, and
similar ones are frequently met with. In none of the cases
I have witnessed was the dog which had inflicted the wound
supposed to have been rabid. In one case which I saw in
this city, with a physician whose name I cannot recall,
the patient, a stableman, was bitten by a dog that was to
all appearance in perfect health. In the case reported by
Dr. Cook, the animal, a bitch, was being led quietly through
the passage-way of the house, when the child became en-
tangled in the chain, fell against the dog, and was bitten
apparently in anger. The animal was well known, and was
not even suspected of being hydrophobic. She was in heat ;
and Dr. Cook raises, for the first time to my knowledge, the
question whether this circumstance renders the saliva of the
animal capable of inducing hydrophobia in the human sub-
ject. "With a view of throwing as much light as possible
on the subject, he consulted the records of Bellevue Hospi-
tal, in order to ascertain the facts in relation to a man who
died of what was supposed to be hydrophobia from the bite
of a bitch in heat. The results of his inquiries were to show
very certainly that the man did die of hydrophobia ; that
the animal was not rabid, and that she was in heat.

It would appear that the saliva is the only means of
communication. Dupuytren, Breschet, and Magendie, en-
deavored to convey the disease by injecting the blood of
dogs, suffering from rabies, into the veins of healthy dogs,
but always unsuccessfully. The flesh, milk, semen, and ab-
dominal secretions, were likewise found not to be media for
transmission.

No other animals than those of the genera canis and
felh have been clearly shown to be capable of communicat-
ing the disease. The power has been claimed for the rat,
but on insufficient evidence. The wolf is said to be the

HYDROPHOBIA.

553

most dangerous of all in this respect, for the reason proba-
bly that it seizes the neck or face, parts not fully protected
by clothing, and thus the saliva is not so apt to be rubbed
off as when the leg, for instance, is the part attacked.

The slightest abrasion of the skin coming in contact
with the saliva may be sufficient for inoculation. Cases are
recorded in which the disease has resulted from dogs licking
the hand or face on which there were pimples or sores.

Diagnosis. — That protean disease, hysteria, occasionally
puts on the semblance of hydrophobia. Several cases of
the kind have occurred to me, and in all the symptoms were
in general character very much like those which are exhib-
ited by genuine hydrophobia, though in some respects, per-
haps, a little exaggerated. It will in these and similar
cases — the result of fright and imagination — often be found
that the patient has been bitten by a dog not long before.
There is a want of consistency about the symptoms which
of itself is sufficient to excite suspicion as to the real char-
acter of the phenomena. Thus, although at times the at-
tempt to swallow will excite laryngeal and other spasms,
these do not always occur under similar circumstances, and
are not induced by those secondary and more refined in-
fluences, such as the sound of falling water, bright lights in
the face, excitations applied to the skin, seeing others drink,
etc., which so generally cause them in the real disease.
There are not the same anxiety and depression in the simu-
lated disease as in the real, though the apparent emotional
disturbance is much greater. The hysterical patient is loud
in the expression of apprehensions, while the real hydropho-
bic one, though intensely anxious and terrified, endeavors
to prevent others perceiving the state of his mind.

The history of the case, the existence of the hysterical
diathesis, and the fact that the symptoms come on soon
after the bite without any period of incubation, will further
aid in establishing the diagnosis between the false and the
real disease.

554

CEREBRO-SPINAL DISEASES.

Hydrophobia lias been confounded with tetanus, and
Bome writers have regarded it as a modified form of this
affection. The distinction is, however, so well marked that
it scarcely seems necessary to dwell upon it. The facts that
in tetanus the spasms are tonic, while in hydrophobia they
are clonic ; that in the first-named they are mainly shown
as regards the jaws and back, while in the latter they radi-
ate from the throat; that in tetanus the mind is clear
throughout, while in hydrophobia more or less mental im-
plication is always present, will suffice to render any mis-
take in the diagnosis of the two diseases impossible.

Prognosis. — There is no authentic instance on record of
a cure of hydrophobia. Several such have been reported,
but inquiry has always shown misstatement or error some-
where. The fact, that the hysterical counterpart has several
times been regarded as the real disease, is the main support
for the opinion of some authors that the affection is curable.

Several years ago Dr. Ligget,' of Maryland, reported a
case of hydrophobia cured by calomel. A careful examina-
tion of the details of this case excites very grave doubts in
my mind in regard to its really being an instance of the dis-
ease in question.

The subject was a negro-woman who had been bitten
about two weeks before any symptoms were manifested.
The dog was lying quietly in the yard, and bit her in the
great toe as she was teasing him with her foot. The animal
was at once chained up, and died in two or three days with
" all the symptoms of rabies canina in its most virulent
form." It does not appear that the doctor saw the dog,
and it is very probable that the rigid confinement would
have caused the animal to exhibit symptoms which would
easily be mistaken by laymen for those of hydrophobia.

Again, the period of incubation was unusually short,
and the symptoms, as detailed by Dr. Ligget, are clearly

1 Case of Hydrophobia successfully treated with Drachm Doses of Calomel,
Am. Jour. Med. Science, January, 1860, p. 96.

HYDROPHOBIA.

555

not those of hydrophobia. Thus, although he repeatedly
states that there was inability to swallow liquids, there is no
distinct mention made of the pathognomonic laryngeal and
pharyngeal spasms which occur in hydrophobia, and which
are so frightful in character. The convulsions all appear to
have been general, and there was a " horror " of water, which
is not a phenomenon of the true disease. For these reasons
I am constrained to believe that the disease treated by
drachm-doses of calomel was in reality one of hysteria which
assumed the form of hydrophobia. In this opinion I am
sustained by an eminent medical gentleman residing in Dr.
Ligget's neighborhood, who, as the latter admits, declared
the affection to be " a case of that protean disease, hysteria,
simulating hydrophobia." Calomel has been repeatedly
tried before and since Dr. Ligget's case, but without effect.

But, although the prognosis is so hopeless in the devel-
oped disease, it is much more favorable as regards the super-
vention of hydrophobia from the bites of rabid animals, for,
of those bitten by dogs unmistakably affected with the dis-
ease, not more than one in fifteen become successfully in-
oculated. This liability differs greatly according to the
circumstance of the part being covered or not. The wounds
of the face, neck, or hands, are much more likely to be fol-
lowed by hydrophobia than those inflicted on the legs or
feet, where the virus is rubbed off by the clothing before the
teeth reach the flesh. The bite of a rabid wolf is more apt
to be followed by the disease than the bite of a dog, for the
reason that the first-named generally seizes the throat or
face. Thus, Trolliet states that at Brives, in France, seven-
teen persons were bitten by a rabid wolf, of whom ten died
of hydrophobia ; and, of twenty-three bitten by another,
thirteen died. On the other hand. Hunter states that on
one occasion a dog bit twenty persons, of whom only one
was inoculated. Those first bitten by a rabid animal are
more liable to have hydrophobia than those bitten subse-
quently, when the poison is in a measure exhausted. Prob-

656

CEREBRO-SPINAL DISEASES.

ably the mpst dangerous wounds are those which barely
penetrate the ej)iderniis, and in which, therefore, the venom
is not washed away by any flow of blood.

Morbid Anatomy. — There are no post-mortem appearances
which can be regarded as peculiar to hydrophobia. The
brain and its membranes are generally congested, as is also
the upper part of the spinal cord with its membranes, but
these changes are met with in other diseases, having no
affinity by their symptoms with hydrophobia.

Sometimes the nerves at the wound are found inflamed,
but this is not a uniform occurrence. The eighth pair has
been found to present a pinkish appearance in some cases.
In four cases in which the blood was examined by Schivardi,'
infusoria of the genera 'bacterium^ monas^ vibrio and torula
were found.

The fauces, pharynx, larynx, trachea, and lungs, are
generally found reddened and congested, as much from the
asphyxia as from any speciflc influence of the disease.

Doubtless with our present knowledge of the intimate
structure of the nervous tissues, and the perfection of our
means of observation, we shall, ere long, be enabled to de-
tect the nature of the changes which take place in hydro-
phobia. Now we know nothing of any importance on the
subject.

Pathology. — Hydrophobia, if we may judge from the
symptoms, essentially consists in a hypersesthetic condition
of the hemispheres, the medulla oblongata, and the upper
part of the spinal cord. The hallucinations and other men-
tal phenomena point to the hemispheres, the irregular ac-
tions of the respiratory muscles, and the heart, together with
the gastric derangement and pharyngeal convulsions, indi-
cate the implication of the pneumogastric nerves, and the
spasms of the larynx point to the origin of the spinal acces-
sory nerves in the spinal cord.

The nature of the virus is unknown. It is probably of
' Observations nouvelles sur la rage. Besan9on, 1868, p. 22.

HYDROPHOBIA.

557

tlie nature of a ferment, but this cannot be regarded as
satisfactorily proved.

In 1820, Dr. Marochetti observed, in the Ukraine, that
during the formative period of hydrophobia small vesicles
or pustules formed under the tongue, and that, if these were
opened and cauterized, the further development of the dis-
ease was prevented. I have never been able to find these
formations, but they were recognized, two years after Maro-
chetti published his account, by Magistral, in France. This
latter opened and cauterized them in the manner recom-
mended by Marochetti in ten cases, in five of which, never-
theless, the aflfection went on to full development, and the
patients died. I am not aware that any one else has discov-
ered these pustules.

For full details relative to hydrophobia as it appears in
dogs, I must refer the reader to the late Mr. Youatt's excel-
lent book on canine madness. I may, however, state that it
is very clearly established that canine rabies is not so fre-
quent in very hot as it is in temperate or cold weather ; that
it is not induced by thirst or improper food, or by prevent-
ing copulation.

Treatment. — The measures of treatment relate to those
proper immediately after the infliction of the wound, with
the view of preventing the development of the disease, and
those advisable after the affection is unmistakably mani-
fested.

Under the first category comes excision, which should be
performed as soon as possible, and which is probably the
best of all prophylactics. The operation should not be done
with a niggardly hand, but every part with which the teeth
of the animal have come in 'contact should be removed, as
well as the tissue into which the poison may have become
infiltrated. Previous to the operation, in fact as soon as
the wound has been received, a tight ligature should be
bound around the limb immediately above the injury, and,
after the knife has done its work, cupping-glasses should be

558

CEREBRO-SPINAL DISEASES.

applied over the spot till the tissues in the vicinity are
thoroughly drained of blood. I have performed excision,
for the Avounds received from dogs certainly rabid, six times,
and always with the effect of preventing hydrophobia.

Cauterization may be performed instead of excision, and
is preferred by some practitioners. Mr. Youatt used it with
over four hundred persons bitten by rabid animals, and
never unsuccessfully. Four times he employed it on him-
self, but there is a strong probability that the practice at
last failed with Mr. Youatt himself, for he committed sui-
cide while supposed to be suffering from the initial symp-
toms of hydrophobia.

He preferred the nitrate of silver as an escharotic.
Others have made use of the actual cautery, caustic alka-
lies, the mineral acids, arsenic, chloride of zinc, and carbolic
acid. I have employed cauterization four times upon per-
sons bitten by rabid dogs, and always with success.

Mr. Youatt at one time had faith that the Scutellaria late-
riflora, or scullcap, was a preventive. He moistened three
pieces of tape with the saliva of a rabid dog, and inserted
them as rowels into the skin of three dogs. To two of these
he gave Scutellaria combined with belladonna, while the
third was left to itself. On the twenty-ninth day after the
inoculation this latter became rabid, while the others, sev-
eral months afterward, were alive and well.

Notwithstanding this experience, it would not be justifi-
able in the physician to neglect performing either excision
or cauterization as soon as possible after the reception of the
bite. Even if several weeks or months have elapsed, one or
the other — preferably excision — should be performed.

As to the treatment of the fully-developed disease, there
is nothing in my opinion which has hitherto succeeded in
arresting its onward course. Cases of cure have been re-
ported, but, as already stated, they are open to the suspicion
of not being true instances of the disease. Excessive blood-
letting has been reported as a successful remedy ; injection

HYDROPHOBIA.

559

of warm water into the veins dissipated the paroxysms in a
case reported by Magendie, the patient, however, dying ;
and nearly every stimulant, narcotic and sedative, in the
materia medica, has been used. In the case which I saw
with Dr. Cook, and which has already been cited, the hy-
drate of chloral was administered. The effect certainly
was to mitigate the severity and frequency of the spasms,
but it was, as Dr. Cook states, given too late in the course
of the disease to produce any permanently curative result.
In the present state of our knowledge, I should be more dis-
posed to rely on the hot-air bath at a temperature of about
200° Fahr., and the administration of hydrate of chloral in
large doses frequently repeated, than on any other plan of
treatment. In Dr. Cook's case the Turkish bath was pro-
posed, but the parents of the child would not consent to its
use.

Before concluding my remarks on this disease, it is prop-
er to allude to the attempts of Dr. Schivardi,' of Milan, to
cure the disease by the primary galvanic current. In one
case the current was feeble, and was continued for nineteen
hours. Great improvement ensued ; the oppression disap-
peared, and the dysphagia was entirely relieved. Through
some misunderstanding, advantage was not taken of these
ameliorations, and the patient was allowed to die.

In the other case, which was one of undoubted hydropho-
bia, occurring in a girl nine years old, the current from twenty-
two Daniell's cells was employed. The current was passed
from the soles of the feet to the forehead for fifty-eight
hours almost continuously, and the duration of the disease
prolonged to seven days and seven hours, when the patient
died. During the last two days there were no hydrophobic
symptoms.

Further trials are necessary before the therapeutical
value of galvanism in hydrophobia can be ascertained.

' Observations nouvelles sur la rage.

CHAPTER II.

EPILEPSY.

Epilepsy, although only a symptom of a morbid condi-
tion, must for the present be considered as a disease, for the
reason that we are not able to designate with certainty its
exact seat, or the nature of the lesion which exists. It is
characterized by paroxysms of more or less frequency and
severity, during which consciousness is lost, and which may
or may not be marked by slight spasm, or partial or general
convulsions, or mental aberration, or by all of these circum-
stances collectively. The essential element of the epileptic
paroxysm is loss of consciousness. "Without that there is no
true, fully-formed epileptic paroxysm.

Symptoms. — Although in many cases there are no pre-
cursory phenomena, it often happens that there are indica-
tions of an approaching attack. These are exceedingly va-
riable in character and situation. They may consist of
pain in the head, a sensation of constriction or fulness, ver-
tigo, noises in the ears, a feeling as if the ears are stopped
with cotton or water, flashes of light, or sudden blindness,
illusions or hallucinations of any of the senses — irritability
of temper, extraordinary cheerfulness, difficulties of speech,
pains in various parts of the body, especially in the stomach,
bowels, or ovaries, sensations of numbness or of tingling, or
of an indescribable character, which begin in an extremity
or in some other region, and appear to pass rapidly to the
head — a feeling of constriction in the throat, vomiting, sud-
den evacuation of the bladder or rectum, erections of the

EPILEPSY.

561

penis, with or without the sexual orgasm, and discharge of
semen, with many otliers of ahnost every possible descrip-
tion.

The prodromata may precede the attack by a consider-
able period, but usually are only a few moments in advance
of it. Indeed, often the interval is so short that they may
be regarded as a part of the paroxysm.

Tlie sensations of numbness, or of tingling, or of an
electric shock, as they are differently described by patients,
or of pain which originate in some distant part of the body,
and seem to run rapidly toward the head, are called the
aura. This aura is usually of the same character in every
attack of the same patient, though occasionally it varies.

Delasiauve,' of two hundred and sixty-four cases, found
the paroxysms unannounced in one hundred and one, and
with precursory phenomena in one hundred and eighty-
three. The prodromata were immediate in one hundred
and tifty cases. These he divides into seven categories, as
follows. It is to be recollected that cases may appear under
one or more categories, according as the prodromata, as is
often the case, are met with simultaneously in different
parts of the body :

FntST Series. — Preoursory Signs in the Head. — Seven-
ty-live cases.

Vertigo, flashes of light . 23

Headache, weight ia the head 15

Heat of face 3

Various localized sensations 13

Indefinite sensations 1

Illusions, hallucinations, and other sensorial aberrations. . 9

Rotation of the head or of the eyes 5

Grinding of the teeth, derangement of the motility of the

tongue 2

Tendency to sleep 1

Constriction of the throat 3

' Traits de I'Epilepsie — ^Histoire — Traitement — Medecine Legale, Paris,
1854, p. 47.

562

CEREBRO-SPINAL DISEASES.

Second Series. — Precursory Signs in the Thorax.—

Twentj-two cases.

Oppression of the chest and sense of suflfocation 9

Sensation of a ball or of motion in the pectoral region 2

Shivering sensation of cold or of an aura 5

Pain or heat ' 4

Palpitations, spasms 2

Third Series. — Precursory Signs in the Abdomen. —
Thirty-two cases.

Pain with or without oppression, eructations, vomiting... 13

Intestinal or uterine colic 3

Sensation of a ball 3

Sensation of cold, of a vapor, etc 6

Stomachal heat 1

Undefinable sensations 6

Fourth Series. — Precursory Signs in the Extremities. —
Ninety-four cases.

Numbness, contractions, jerkings, retractions, cramps,

formications, etc 36

Pain with or Asdthout spasms 13

Tremblings 10

Aura or phenomena approaching thereto 20

Undefinable sensations 15

Fifth Series. — Precursory Signs, consisting of General
and Undefinable Sensations. — Twenty-two cases.

General agitation or rotation of the body 8

Condition of discomfort, faintiag, etc 6

Vague sensations 7

Moroseness 1

Sixth Series. — Precursory Signs situated in the Geni-

tal Organs. — Five cases, such as retraction of the testicles,
aura starting from the testicles and spermatic cords, sensa-
tions located in the uterus, etc.

Seventh Series. — Exceptional Cases. — Desire to defe-
cate, to urinate, profuse perspiration, etc.

EPILEPSY.

563

Of two hundred and eighty-six cases of epilepsy which
have come under my observation, and in which inquiry was
made as to the occurrence of prodromata, I ascertained that
they existed in one hundred and twenty-eight. They did
not differ in general character from those specified by De-
lasiauve.

The Paroxysm. — Great differences are observed in the
character and severity of the paroxysm. Ordinarily two
varieties are recognized, the jpetit mat or slight attack, and
the grand mal or severe seizure. The first is unattended
by marked spasm or agitation ; the latter is characterized
by more or less violent tonic and clonic convulsions.
These divisions are, however, not regarded as sufiiciently
precise by those who have studied the disease in question
with care and precision, and more minute classifications of
the phenomena of the epileptic paroxysm have accordingly
been made. The one which I have used in my lectures at
the Bellevue Hospital Medical College for several years
past is less complex than some others, and embraces all the
known varieties. It is as follows :

1. Momentary unconsciousness without marked spasm.

2. Unconsciousness with evident though local spasm.

3. Unconsciousness with general tonic and clonic con-
vulsions.

4. Irregular or aborted paroxysms.

Besides these several varieties, there are certain accom-
paniments, such as mania and paralysis, which will require
consideration.

1. llomentary Unconsciousness without Evident Spasm.
— The patient is perhaps standing, engaged in conversation,
when a momentary blank in his mental processes occurs.
It probably does not attract attention ; it is instantaneous,
disappears, leaving no feeling of discomfort after it, and
there is an almost immediate continuance of his thoughts
and speech.

Or he may be walking in the street when the accession

564

CEREBRO-SPINAL DISEASES.

occurs. He loses himself for an instant, but he continues
to walk, and does not even stagger.

In somewhat more severe seizures, if conversing, he stops
suddenly, stares vacantly but fixedly for a moment, and may
drop any thing which he has in his hand.

If walking, his steps are arrested for an instant, he stag-
gers and would fall but for the quick return of conscious-
ness.

Such is the general character of these absences, faints,
spells, etc., as they are popularly called ; varying, however,
according to the circumstances of the moment and the con-
dition of the patient. They frequently exist for a long time
without the patient paying much attention to them. In a
gentleman now under my charge they occurred several times
in the course of the day when walking, riding on horseback,
sitting quietly in his library, engaged in conversation, or
eating. He did not consider them of much importance, and
was surprised when I informed him they were epileptic.
The continuity of his acts was scarcely interrupted, and
those about him never noticed that any thing was wrong.

In the case of a young lady they occur generally at the
dinner-table. She drops her knife and fork, looks steadily
to the front, ceases to eat, and in about two seconds resumes
her occupation with a long-drawn inspiration. Those near
her observe that her countenance becomes very pale, and
that she does not hear or see.

Sometimes these attacks, slight as they are, are fol-
lowed by pain in the head, vertigo, confusion of ideas,
numbness, and other evidences of nervous derangement,
which may last for several hours, and which become more
pronounced as the epileptic condition becomes more con-
firmed.

2. Unconsciousness, with Evident though Local Spasm. —
In this variety the loss of consciousness is of longer dura-
tion than in the preceding, and is attended witli convulsions
light in character, but yet apparent to those around. The

EPILEPSY.

565

eyes are fixed, as in the first variety, the mind becomes a
blank, and there is a sensation of vertigo immediately be-
fore the loss of consciousness, and at the time of its restora-
tion. The face usually becomes pale first and then red, or
either of these conditions may occur without the other being
observed.

The spasms may be very slight. Sometimes there is
momentary strabismus, at others retraction of the angles of
the mouth on one or both sides, rotation of the head or a
sudden drawing of it backward, or the tongue is thrust for-
ward and the jaws close on it, inflicting slight injury.
Again, the chair in which the patient may be sitting is
pushed back with some force, and the body is bent forward,
or the muscles of the neck may be affected, and the circula-
tion thus interrupted in the veins of the neck, causing a dark
hue of the complexion.

Sometimes the spasms have an appearance of being
volitional. A patient under my charge tugs violently at
his hand ; another walks about the room, but without tak-
ing any determinate course ; a young lady leaves her chair
and stands upon another one at some distance from her, and
another talks all kinds of gibberish. My experience of
such cases is in accordance with that of Reynolds,' to the
effect that there is no recollection of these acts. These
attacks are often preceded by prodromata of various kinds.
The duration never exceeds a minute, and is generally much
less.

3. Unconsciousness^ with General Tonic <md Clonic Con-
vulsions.— Prodromata may or not be present. In any event
the paroxysm occurs suddenly. The first circumstance may
be a cry of a very peculiar character, somewhat resembling
the bleating of a young lamb. The eyes become fixed, and
the patient falls to the ground, usually with a bound, as if
he is shot. The loss of consciousness occurs with the cry or
the fixedness of the gaze.

1 System of Medicine, vol. ii., p. 261, Art. Epilepsy.

566

CEREBRO-SPINAL DISEASES.

The muscles are now thrown into a state of tonic con-
traction ; the respiration is impeded, or altogether arrested ;
the face, if at first pale, becomes dark ; the pupils are dilated,
and sensibility is entirely abolished.

Careful examination of a patient in this stage of tlie
paroxysm reveals some important features : the body is rigid,
but is usually inclined more to one side than the other, in
the position of a tetanic patient with pleurosthotonos ; the
eyes are open, and are twisted to one side ; the face is
likewise more retracted on one side than the other ; the
sterno-cleido-mastoid muscles, and others of the neck, stand
out like thick cords ; the carotids throb with force ; the
veins of the head and neck are turgid with black blood, and
the pulse is usually weak and fluttering.

After this stage has lasted for a period varying from two
or three seconds to half a minute, a great change ensues.
The unconsciousness continues, but the general tonic spasm
relaxes, and clonic convulsions take its place. These are
general, but are ordinarily more strongly marked on one
side of the body than on the other. The muscles of the
face are alternately contracted and relaxed ; the tongue is
often thrust between the teeth, and, the jaws being closed
upon it, it is terribly injured ; the upper and lower extremi-
ties are in a state of continued agitation, and the contents
of the bladder, rectum, and vesiculse seminales, may be
evacuated.

The respiration is forced and irregular, froth issues from
the mouth, and, if the tongue has been bitten, it is colored
with blood.

The muscles of the neck do not relax to any considera-
ble extent ; consequently the veins remain distended, aud
the face continues to be livid. The pupils oscillate, some-
times being dilated and then contracted, or one may be con-
tracted and the other dilated. The heart beats with great
irregularity, both as to force and frequency.

This stage may last from a few seconds to five minutes.

EPILEPSY.

567

Cases of longer duration are on record, but they are exceed-
ingly rare.

The third stage of the paroxysm is characterized by the
gradual return of consciousness. The patient, though still
somewhat convulsed, looks around him and gives evidence
of returning sensibility in other ways. The pupils cease
their disorderly movements, and are contracted ; the respi-
ration and pulse become more regular, and he may even
attempt to speak. It often happens that little spots of ex-
travasated blood make their appearance under the skin of
the forehead, eyelids, cheeks, and sometimes on the neck
and breast. These disappear in a few days.

The duration of this stage is from a few seconds to four
or five minutes, and it is often so slightly marked as to
escape observation.

With the cessation of the convulsive movements the
stage of stupor usually supervenes, though it may be en-
tirely absent, especially in old cases of epilepsy. During
this stage there are sometimes clonic spasms of no great
degree of severity. It may last a few minutes or several
hours. When the patient arouses from it, he generally has
headache, and a feeling of lassitude and soreness of the mus-
cles, from the violent contractions they have undergone.

4. Irregular or Aborted Paroxysms. — In these it may
happen that the loss of consciousness is not complete, or
that the patient has convulsive movements partial in char-
acter and accompanied simply by vertigo, or he may have
unconsciousness lasting for an hour or more, during which
he performs automatic acts, of which he has no recollec-
tion, but which are not accompanied by any movements
that can properly be called spasmodic.

In his interesting lecture on " Apoplectiform Cerebral
Conarestion," Trousseau * cites a number of cases which were
clearly instances of irregular or aborted epileptic paroxysms.
Among them is that of a magistrate whose sister was an

' Op. cit., Bazire's Translation, p. 19, ei seq.

568 CEREBRO-SPINAL DISEASES.

inmate of a lunatic asylum. He was president of a provin-
cial tribunal. One day lie got up all of a sudden, muttered
a few unintelligible words, and went to the deliberating-
room. The usher followed him, and saw him make water
in a corner. A few minutes afterward he retm'ned to his
seat, and again listened with intelligence and attention to
the pleadings momentarily interrupted. He had no recol-
lection of the incredibly incongruous act he had committed.
This gentleman belonged to a literary society, which held
its meetings at the Hotel de Ville, of Paris. At one of
these, during the discussion of an important historical point,
he was seized with vertigo. He ran quickly down to the
Place de Hotel de Yille, and walked about for a few min-
utes on the quays, avoiding with success both carriages and
the passers-by. On recovering himself he perceived that he
had come out without his great-coat and his hat. He there-
fore returned to the meeting, and resumed with a perfectly-
lucid mind the historical discussion in which he had already
taken a very active part. He retained no recollection what-
ever of what had occurred between the beginning of the at-
tack and the moment he recovered himself.

Many cases similar to these might be cited from other
authors. From a number which have happened in my own
experience I adduce the following :

J. H. consulted me for epilepsy in the summer of 1869.
His ordinary attacks were of the fully-developed form ; but
upon two occasions they were different from any with which
he had previously been affected. On one of these, while
overlooking some workmen, he was observed to put his
hand to his head, and then suddenly to run toward a fence,
which he speedily climbed. Jumping dowm into the back-
yard of tlie adjoining house, he seized a stick of wood near
by, and made a furious onslaught on the door and windows.
While thus engaged he was seized by several men, and for-
cibly held notwithstanding his struggles. While thus be-
ing restrained he recovered his consciousness, but had no

EPILEPSY.

569

recollection of any thing which had taken place after he had
put his hand to his head, which action he said was due to
severe pain with vertigo. The duration of the attack was
not over three minutes.

On the other occasion he was seized with pain and ver-
tigo while engaged in paying a bill at a coal-yard. He
rushed into the street, and began to turn rapidly round.
He was seized and held till he recovered his consciousness.
This attack lasted about four minutes.

Subsequently he had a similar paroxysm in my consult-
ing-room. His face suddenly became very pale, his eyes
were fixed, and his pupils oscillated. Suddenly he rose
from the chair, grasped the mantel-piece for an instant, and
then rushed violently around the room, throwing his arms
about, and uttering a peculiar inarticulate cry. I made no
attempt to restrain him, and in about two minutes he be-
came calm. During the whole paroxysm his face was pale,
and at its close the pupils were dilated. He had no recol-
lection of any thing which had occurred after he rose from
the chair, but was conscious then of vertigo.

Another case is that of a girl brought to my clinic at the
Bellevue Hospital Medical College during the summer of
1869. She had been severely injured in the skull by a fall
against a mass of old iron. Necrosis subsequently ensued,
and several large pieces of the external table were exfoliated.
While before the class, she started to her feet, and walked
several times around the closed area. She was unconscious,
and to all appearance insensible. When the paroxysm was
over, she returned to her seat. The duration did not ex-
ceed a minute, and there was no excitement or delirium.

Cases such as these are sometimes classed as epileptic
mania, but it is better to restrict this term to those parox-
ysms of mental aberration which come on after a true epi-
leptic attack.

Epileptic fits may take place at night during sleep, and
the patient be unaware of their existence, unless he in-

5Y0

CEREBRO-SPINAL DISEASES.

flicts some injury on himself, sucli as biting his tongue, or
is told of their occurrence by persons who may be in the
same room with him. In two hundred and six of my cases
the period of access is noted, and of these forty-seven were
nocturnal, and one hundred and fifty-nine diurnal.

In the intervals between the paroxysms epileptics often
exhibit certain evidences of disordered mental, sensorial,
and motor functions. Thus, as regards the first category,
the memory may be impaired, and there may be diminished
mental power. There are, however, many exceptions to
this rule ; and, even where there have been a great many at-
tacks, the mind may preserve its normal degree of integrity.
As Reynolds remarks, in regard to this point : " A patient
may be epileptic and a lunatic ; he may be epileptic and
asthmatic, but there are some epileptics whose minds are as
healthy as their lungs ; and, so far as the natural history of
epilepsy is concerned, it is a mistake to derive it from com-
plicated cases." Still, in the majority of cases, it will be
found that the mind sooner or later becomes involved, and
it sometimes happens that a single attack causes marked
intellectual deterioration.

Derangements of sensibility are common from the be-
ginning. Headache, a feeling of constriction around the
forehead, and occasionally a pain at the back of the head,
are noticed. Vertigo is also frequently present, as are also
sensations of nmnbness in different parts of the body. The
pupils are almost invariably dilated.

The motor power of the patient is generally weakened
without there being any decided paralysis. Twitchings of
the muscles are not uncommon, and there is often a general
excitability of the reflex faculty of the spinal cord, by which
jerkings of the limbs are produced by slight excitations.

In examining with the ophthalmoscope the fundus of the
eye in epileptics, we can often detect evidences either of
cerebral congestion or of anaemia, and thus obtain valuable
indications for treatment. During the last two years, in my

EPILEPSY.

571

lectures at the Bellevue Hospital Medical College, I have
constantly insisted on this point, and in my cliniques have
exhibited several cases in which I had been guided to suc-
cessful treatment by the ophthalmoscope. Drs. Kostle and
Niemetshek,* of Prague, consider that the brain in epilep-
tics is always ansemic, and that this condition is invariably
found by ophthalmoscopic examination. According to these
observers, the venous pulse is produced when the eye is
made anaemic, and they assert that the retina is anaemic,
and that there is consequently venous pulsation in every
case of epilepsy. That this opinion is erroneous, both as to
facts and inferences, I am very sure. Yenous pulsation, so
far from being indicative of anaemia, really shows the ex-
istence of the very opposite condition. My observations
are, however, to the effect that venous pulsation is present
in many cases of epilepsy, and that it accompanies dilata-
tion of the veins.

There is no invariable rule as regards the occurrence of
any particular form of epilepsy in the same person. It thus
often happens that all the varieties of paroxysm mentioned,
except the irregular or aborted form, which is more rare,
are met with in one individual. The more severe form
may occur at longer intervals, and the milder forms more
frequently. As regards frequency, there are great varia-
tions. Some patients go a year or more without attacks,
while others have several every day. It generally happens
that the intervals become progressively shorter. As a rule,
attacks of the milder forms are more frequent than the fully-
developed paroxysm, and attacks of the latter are milder, as
they are more frequent.

Mania is sometimes a consequence of epilepsy. It
comes on after the attack, and is rarely of more than a
few minutes' duration. Those cases in which it precedes
the paroxysm, and lasts several hours or days, are cases of

' Prager Vierteljahrschrift, H. 106, lOY, 1870, and Quarterly Journal op
Psychological Medicine, January, 1871, p. 128.

572

CEREBRO-SPINAL DISEASES.

mania conjoined with epilepsy — a combination which, as
every insane asylmn shows, is not uncommon. The mania
of epilepsy is usually of a very exalted character, and dur-
ing its existence the subject may commit homicide or other
crimes.

The mental state of epilepsy has been well studied by
Falret,' and a very interesting case has been recently re-
ported by Dr. Thorne,' in a paper entitled "Masked Epi-
lepsy." In this instance the patient often returned to his
home without being able to give any account of what he
had been doing or where he had been. During these at-
tacks he was frequently the subject of that form of mental
derangement called kleptomania. Generally they ensued
on paroxysms either of the grand or petit mal, but some-
times they were substituted for the regular seizures. He
had no recollection of what transpired during the attacks.
Sometimes he was furiously excited in them, and would en-
deavor to injure himself and others in his blind rage.

The medico-legal relations of epilepsy do not, however,
come within the scope of the present treatise.

Paralysis may follow epilepsy, but, unless the case is
complicated with some organic difficulty of the brain or
spinal cord, the loss of power is temporary.

Causes. — Among the predisposing causes of epilepsy he-
reditary tendency stands first. Keynolds' states that, in
about one-third of the cases under his observation, heredi-
tary taint existed. He does not, by this statement, how-
ever, mean to assert that epilepsy existed in one-third of
the parents, but that some disease of the nervous system,
more or less closely allied to epilepsy, was present in
either the parents, the grandparents, the aunts, uncles,
brothers, or sisters. Only twelve per cent, of his cases

1 De I'Etat Mental des 6pileptiques. Archiv. Gen. de Med., Decembre, 1860,
et Avril, et Octobre, 1861.

* St. Bartholomew's Hospital Reports, 1870.
8 Op. cit., p. 253,

EPILEPSY.

573

gave a distinct history of epilepsy in either branch of their
families.

Herpin/ of sixty-eight cases, found that ten were de-
scended from epileptic ancestors.

Delasiauve/ of three hundred cases, found decided evi-
dence of hereditary tendency in thirty-three. In one
hundred and sixty-seven there were no data, and in one
hundred and twenty hereditary taint was denied. Of the
thirty-three cases, live were descended from epileptic an-
cestors.

Sieveking ' found that hereditary influence was present
in 11.1 per cent, of his cases.

In my own experience I have notes in regard to this
point in one hundred and seventy-one cases. Of these,
twenty-one had epileptic fathers, mothers, grandparents,
uncles, aunts, brothers, or sisters, and twenty-four had rela-
tives insane, hysterical, cataleptic, atfected with severe neu-
ralgia, or of remarkably irritable nervous systems.

Sex does not appear to exercise any appreciable influence
as a predisposing cause. Of two hundred and six cases
noted by myself, one hundred and ten were in males and
ninety-six in females. Other authors have, however, had
directly opposite experience.

Age has a very decided influence. Reynolds gives the
following table of one hundred and seventy-two cases col-
lected by himself :

Age at Commencement.

Males.

Females.

Total.

106

102

1*72

' Du Pronostic et du Traitement Curatif de I'Epilepsie, Paris, 1852, p. 325.
2 Op. cit., p. 189. ^ On Epilepsy, etc., London, 1858, p. 74.

574 CEREBRO-SPINAL DISEASES.

My own cases were as follows :

Age at Commencement.

Males.

Females.

Total.

107

110

206

It is thus seen that the period of life between ten and
twenty years is that at which epilepsy is most apt to occur.
The experience of others is to the same effect. The influ-
ence of temperament has been thought important by some
writers. But, aside from the different opinions entertained
relative to the characteristics of the temperaments, it is by
no means established that, even when strictly defined, tem-
perament exercises any effect as a predisposing cause. I
have no accurate records on this point, though so far as my
memory serves me I have observed no marked predominance
of epileptics with any temperament.

The exciting causes may very properly be classified as
psychical, eccentric, general organic changes, and physical
influences. Relative to the influences of these causes, Rey-
nolds gives the following table :

Nature of Cause. No. of Cases.
I. Psychical — such as fright, grief, worry, overwork. . 29
n. Eccentric irritation — dentition, indigestion, vene-
real excesses, dysentery, etc 16

III, General organic changes — fetigue, pregnancy, mis-

carriages, rheumatic fever, scarlet fever, diph-
theria, pneumonia 9

IV. Physical influences — blows on head, falls, insola-

tion, cuts 9

In my own cases no cause could be assigned in one hun-
dred and four. The remaining one hundred and two cases
were, according to the evidence received, caused as follows :

EPILEPSY. 575

Fright 5

Anxiety 4

Grief 6

Over-mental exertion 17

Dentition 11

Indigestion ... 11

Venereal excesses 15

Menstrual derangement 10

Blows on head 7

Falls 3

Sunstroke 3

Scarlet fever 3

Measles 1

Diphtheria 3

Pregnancy 3

Syphilis 3

103

Diagnosis. — The diagnosis of epilepsy presents no diffi-
culties to the careful observer. It may, however, be con-
founded with several conditions, the principal of which are
cerebral congestion, cerebral haemorrhage, hysteria, the
convulsions of infancy and of Bright's disease, poisoning
by opium and alcohol, syncope, and with the convulsions
of epileptiform character which occur in the course of cer-
tain organic diseases of the brain.

The diagnosis from cerebral congestion and cerebral
haemorrhage has already been given in the chapters treat-
ing of these affections. In hysteria, the convulsions, which
are sometimes epileptiform in character, are preceded or ac-
companied by other evidences of the hysterical state. Con-
sciousness is rarely entirely lost, the tongue is not bitten,
and there is no subsequent stage of stupor.

The convulsions of infancy not epileptic are not repeat-
ed but from a readily-ascertained exciting cause, such as
dentition, indigestion, falls, etc. So far as the paroxysm is
concerned, I know of no specific points of difference ; but it
must be recollected that the paroxysm is not the only fea-

576

CEREBRO-SPINAL DISEASES.

ture of epilepsy, and that it is tlie only feature of infantile
convulsions. These latter may pass into epilepsy ; but, if
they do not, I have never been able to find a single case in
my experience in which epilepsy ensuing in adult life has
been preceded by the ordinary infantile convulsions. In
Bright's disease, though the convulsions may be epilepti-
form in character, coma is the principal feature, and the
history of the case will further serve to render the diagnosis
exact. The same remarks are applicable to poisoning by
opium and alcohol.

From syncope epilepsy is distinguished by the facts that
the loss of consciousness is sudden and complete, that the
pulse is not feeble, and that recovery is rapid. These re-
marks apply to the milder attacks without convulsions.
From the more severe forms of the paroxysm the distinction
is too obvious to require amplification.

In organic diseases of the brain, such as tumors, soften-
ing, sclerosis, etc., the accompanying symptoms, pain, pa-
ralysis, tremor, imbecility, difiiculties of speech, and de-
rangements of the special senses, will serve to distinguish
them from epilepsy.

Epilepsy is often assumed by designing persons for pur-
poses of fraud. In such cases the pretender usually overacts
his part ; his sensibility is not abolished, as may readily be
ascertained by putting the end of the finger on the conjunc-
tiva, and the size of the pupils is not altered.

Prognosis. — The prognosis depends to a great extent on
the duration of the disease. Kecent cases can often be
cured, but those which have lasted for several years are
rarely brought to a favorable termination. Among the
other unfavorable elements are the existence of hereditary
influence, the beginning of the disease late in life, the pres-
ence of material mental weakness, and the existence of long
intervals between the attacks.

As regards the probability of the supervention of any
form of intellectual derangement or debility, the most im-

EPILEPSY.

577

portant ascertained point is tliat the mild paroxysms unat-
tended by convulsions are more productive of mental decay
than the severe form of seizure. The occurrence of the first
attack late in life is likewise a predisponent to dementia.

I have never, in my own experience, known death to
take place during a paroxysm of true epilepsy ; such cases,
however, do occur. Usually, however, some intercurrent
afiection carries the patient off, though even with this lia-
bility life is sometimes astonishingly jDrolonged. I am ac-
quainted with the case of a lady who is now sixty-five
years of age, and who, since her tenth year, has averaged
six paroxysms daily, all of the severest character. Her
mind is almost entirely gone, but physically her health is
excellent, and to all appearance she may live twenty years
longer.

I am not aware of any exact observations tending to
show the relative danger to life of attacks of the milder and
severer forms ; though it is reasonable to suppose that, so
far as regards the occurrence of death during the paroxysm,
the con^^llsive form is more fatal.

Morbid Anatomy. — In post-mortem examinations of per-
sons dying epileptic, abnormal conditions are found in every
part of the brain and spinal cord. Some of these lesions
are undoubtedly secondary, others unessential, while those
which may be considered primary vary in their seat and
character. In a great many cases, perhaps the majority, no
lesions are discoverable.

No one has been more thorough in the search for the
essential cause of epilepsy than Schroeder van der Kolk ; *
though his observations can scarcely be regarded as yielding
conclusive results, they serve to show, when taken in connec-
tion with the pathology of the disease in question, that its
seat is mainly in the medulla oblongata, with secondary im-

' On the Minute Structure and Functions of the Medulla Oblongata, and on
the Proximate Causes and Rational Treatment of Epilepsy. New Sydenham
Soc. Translation, London, 1859.
37

578

CEREBRO-SPINAL DISEASES.

plication of other parts of the cerebro-spinal nervous system.
Oftentimes, in accordance with other pathologists, he found
nothing to account for the affection, but at others he found
hardening and contraction of the medulla oblongata, and
again degeneration of the brain either as a consequence or
cause of the disease. Microscopical examination sometimes
showed him the medulla indurated, sometimes softened, and,
as a constant phenomenon, " whether the patient died in or
out of the fit, great redness and vascular tension in the
fourth ventricle, penetrating into the medulla oblongata
sometimes to a considerable depth." These appearances
were due to enlargement of the blood-vessels, as was shown
by microscopical measurements. It is probable, however,
as Schroeder van der Kolk asserts, that the lesions in ques-
tion are the results, and not the causes, of the paroxysms.
Still they suffice to indicate the main seat of the disease to
be the medulla oblongata.

Other observers have not so uniformly found this en-
largement of the blood-vessels of the medulla. In three
cases of death occurring in epileptics, in which I have had
the opportunity of making post-mortem examinations, they
certainly did not exist, nor was there any other lesion de-
tected by the most careful microscopical exploration. In
one other case the vessels of the medulla oblongata were en-
larged, and there was amyloid degeneration of the pituitary
body.

Pathology. — The points which may be considered as to
some extent established relative to the pathology of epilepsy
are briefly summarized as follows by Reynolds : '

" 1. That the seat of primary derangement is the me-
dulla oblongata and upper portion of the spinal cord.

" 2. Tliat the derangement consists in an increased and
perverted readiness of action in these organs, the result of

* Op. cit., p. 275, and more fully stated in his Treatise on Epilepsy, its
Symptoms, Treatment, and Relations to other Chronic Convulsive Diseases,
London, 1861, chapter v., p. 238.

EPILEPSY.

579

such action being the induction of spasm in the contractile
fibres of the vessels supplying the brain, and in those of the
muscles of the face, pharynx, larynx, respiratory apparatus,
and limbs generally.

" By contraction of the vessels the brain is deprived of
blood, and consciousness is arrested ; the face is or may be
deprived of blood, and there is pallor ; by contraction of the
vessels which have been mentioned, there is arrest of respi-
ration, the chest walls are fixed, and the other phenomena
of the first stage of the attack are brought about.

"3. That the arrest of breathing leads to the special
convulsions of asphyxia, and that the amount of these is in
direct proportion to the perfection and continuance of the
asphyxia.

"4. That the subsequent phenomena are those of poi-
soned blood, i. e., of blood poisoned by the retention of car-
bonic acid, and altered by the absence of a due amount of
oxygen.

" 5. That the primary nutrition-change, which is the
starting-point of epilepsy, may exist alone, and epilepsy be
an idiopathic disease, i. e., a morbus jper se.

" 6. That this change may be transmitted hereditarily.

" 7. That it may be induced by conditions acting upon
the nervous centres directly, such as mechanical injuries,
overwork, insolation, emotional disturbances, excessive ve-
nery, etc.

" 8. That the nutrition-changes of epilepsy may be a
part of some general metamorphosis, such as that present in
the several cachexias — rheumatism, gout, syphilis, scrofula,
and the like.

" 9. That it may be induced by some unknown circum-
stances determining a relative excess of change in the me-
dulla during the general excess and perversion of organic
change occurring at the periods of puberty, of pregnancy,
and of dentition.

" 10. That it may be due to diseased action, extending

580

CEREBRO-SPINAL DISEASES.

from contiguous portions of the nervous centres or their
appendages.

"11. That the so-called epileptic aura is a condition of
sensation or of motion, dependent upon some change in the
central nervous system, and is, like the paroxysm, a pe-
ripheral expression of the disease, and not its cause."

While admitting the correctness of these conclusions,
they do not, in my opinion, tell the whole story of the the-
ory of epilepsy. In very many memoirs Dr. Brown-Sequard
has pointed out the dependence of the affection upon inju-
ries of the upper part of the spinal cord, and upon irrita-
tions existing in various parts of the body. His researches,
and facts observed every day by physicians who see many
cases of epilepsy, show very conclusively that the starting-
point is often in the sympathetic nerve — the nerve by which
the calibre of the blood-vessels is regulated.

N^either can I accept the view that the first intra-cranial
condition producing a paroxysm is in all cases spasm of
the blood-vessels and the consequent deprivation of the
blood-supply to the brain. On the contrary, I am very sure
that the primary state is often paralysis of the cerebral
blood-vessels and resulting hypersemia. By this condition
the medulla oblongata is thrown into a state of over-excita-
tion, giving rise to convulsions, and consciousness is lost
from the fact that the hemispheres participate. That con-
vulsions epileptiform in character may be produ(;ed both by
cerebral anaemia and cerebral hypersemia, when either con-
dition involves the medulla oblongata, is a fact which ex-
periment has abundantly established, and that loss of con-
sciousness follows either condition involving the hemispheres
is equally certain. We have, consequently, two kinds of
epilepsy — the one due to anfemia, the other to congestion —
and it is to this fact that is due the circumstance that some-
times the paroxysms are prevented by measures which tend
to increase the amount of blood in the brain, and at others
by remedies which exercise a contrary influence. The ex-

EPILEPSY.

581

istence of the two species of epilepsy is likewise shown by
ophthalmoscopic examination — a point upon which I have
already insisted.

During natural sleep the amount of blood is, as I have
elsewhere shown, decreased from the quantity which circu-
lates in the cerebral blood-vessels during wakefulness. Epi-
lepsy occurring during sleep is therefore of the anaemic va-
riety. But it often happens that sleep passes gradually into
stupor, from the fact that causes tending to increase the flow
of blood to the brain, or to arrest its passage from this or-
gan, are in operation. In such cases epilepsy of the conges-
tive variety may be induced.

In those cases in which the tongue is bitten the medulla
oblongata is probably always in a condition of hyperemia ;
and this state, as Schroeder van der Kolk has very conclu-
sively shown, is mainly in the course of the roots of the
hypoglossal nerve. The intermissions between the attacks
are ingeniously explained by the same able observer, by
likening the cells of the medulla oblongata to Leyden jars
charged with electricity, or to the electrical organs of the
conger-eel and torpedo. After being discharged, time is
necessary for the reaccumulation of sufiicient electricity to
discharge them again ; and, when the cells of the medulla
have once discharged themselves in an epileptic convulsion,
a period must elapse before another access can take place.

The foregoing remarks apply in the main to that form
of epileptic seizure characterized by convulsion. In the
imperfectly-developed attacks the implication of the me-
dulla oblongata must be very slight, the hemispheres being
the organs mainly aflfected, and the condition being some-
times anaemic, at others hypersemic.

It must not be supposed, from what has been said, that
simple cerebral anaemia and simple cerebral congestion, at-
tended with epileptiform convulsions, are identical with the
anaemia and congestion of epilepsy. This disease is cerebral
anaemia or congestion with another element, the exact na-

582

CEREBRO-SPINAL DISEASES.

tiire of which we do not understand, but which is certainly
of such a character as to constitute the main differential
point between epilepsy and any other affection.

Treatment— To attempt the consideration of all the
means which have been employed in the treatment of epi-
lepsy would be a hopeless task. Their mere mention would
require several pages of this treatise. I shall therefore con-
tent myself with detailing the methods which I have found
most useful.

First among remedies are the bromides of potassium,
sodium, or lithium. The first should be given to adults in
doses of at least fifteen grains three times a day, and is gen-
erally required in larger quantity. It acts very much bet-
ter when largely diluted with water. A saturated solution
contains about thirty grains to the drachm, and a half a tea-
spoonful or more should be mixed in at least a gill of water.
Latterly I have used the bromide of sodium in doses a little
smaller. It is, I think, more readily assimilated, and is less
apt to produce gastric irritation, but, in other respects, its
action is similar to that of the corresponding potassium
salt. The bromide of lithium has a more immediate ac-
tion ; but I have not succeeded in obtaining any continuous
effects from it in epilepsy which I could not derive from the
potassium or sodium salt, and its great cost is a bar to its
lengthened administration.

It must be clearly understood that the bromide is to
be taken for at least a year, and in most cases longer, before
its administration is stopped. After the initial dose has
been given for about two months, if there are no symptoms
indicating bromism, I increase the doses by one-half, if
there has been no paroxysm in the mean time. If there
have been paroxysms, I increase by one-half after each
paroxysm until they are arrested, or until I am convinced
that the bromide is inefficacious or injurious. In the case
of a gentleman from Cincinnati, I began with twenty grains
three times a day ; he still had attacks ; I increased the

EPILEPSY.

583

doses to thirty grains, with little or no effect ; then to forty-
five grains, and, as he still had an occasional fit, I increased
the doses to fonr a day. He therefore took one hundred
and eighty grains a day, and then his paroxysms ceased. I
have never given beyond this quantity, and, if it had not
proved successful, I should have abandoned the idea of ar-
resting the disease with the bromide of potassium. The
gentleman in question has had but one attack during the
last three years, and this was the result of his suddenly
omitting to take his medicine for several days. When he
was thoroughly under the influence of the drug, I reduced
the doses, and he now takes thirty grains three times a day.
He had been previously treated with smaller doses, with
good effect at first, but for some time before he came under
my care they had lost their influence.

With either bromide I usually conjoin the oxide of zinc
in doses of two grains three times a day. In several cases
in which large doses of the bromide had failed, the parox-
ysms were arrested when the oxide of zinc was given in
addition. In one case in which the bromide ao-o-ravated the
disease, and in which the oxide of zinc was ineffectual, the
patient, a young lady of this city, was cured after taking the
lactate of zinc in doses of four grains three times a day. In
no other case has this salt produced the least effect in my
hands.

I rarely continue the oxide of zinc for a longer period
than two months, for the reason that it appears, after that
period, to produce a cachexia, manifested by loss of appe-
tite, anaemia, and general debility.

With the bromide I generally administer strychnia in
doses of the thirty-second to the twenty-fourth of a grain,
for the purposes of a tonic, and for counteracting, to some
extent, the debilitation produced by the bromide.

When the opportunity affords, I always make use of the
con stant galvanic current, applying it to the brain and sym-
pathetic nerve. There should ordinarily be three seances a

584:

CEREBRO-SPINAL DISEASES.

week, eacli of about ten minutes. For one-third of this
time I pass the current antero-posteriorlj, one pole being
placed on the back of the neck, and the other on the fore-
head ; for another third, one pole is placed on each mastoid
process, and for the other, one on the sympathetic nerve in
the neck, and the other on the spinal column at about the
first dorsal vertebra. The current should be derived from
ten or fifteen Smee's or Daniell's elements.

Occasionally I have employed setons — a skein of silk, or
a piece of thin india-rubber, being passed through the skin
of the nucha.

The results obtained are shown in detail in the following
synopsis :

One or other of the bromides was given in two hundred
and eighty-six cases.

The condition of the patient was aggravated in nineteen
cases ; all were of the nocturnal form, and one has beeu re-
ported in detail.^

No appreciable efiect was produced from doses of one
hundred and twenty grains a day in twenty cases, and the
administration was stopped. Eleven of these were noc-
turnal.

1^0 appreciable efiect from doses of one hundred and
sixty grains a day in four cases, and the medicine was ac-
cordingly discontinued.

The severity and frequency of the fits were diminished,
but they were not arrested, with doses ranging from forty-
five to one hundred and sixty grains daily, in one hundred
and fifty-two cases.

1^0 fits occurred while the bromide was being taken, in
ninety-one cases. Of these latter the bromide has been
stopped for over six months, and there has been no return
of the fits in sixty-five cases.

In the remaining twenty-six cases the bromide has to

' A Case of Epilepsy due to Cerebral Anasmia, Journal of Psychological
Medicink, April, 1868, p. 368.

EPILEPSY.

585

be continued in order to prevent the recurrence of the par-
oxysms.

Of the two hundred and eighty-six cases in wliich the
bromide was administered, the seizures were therefore en-
tirely arrested or lessened in frequency or severity in two
hundred and forty-three, while in foi'ty-three it was either
positively injurious or without effect.

Of the two hundred and forty-three completely or par-
tially successful cases, the bromide was combined with oxide
of zinc in seventy-four.

Of these seventy-four cases, fifty-two were, of the sixty-
five, thoroughly successful cases.

The primary galvanic current was used to the brain, me-
dulla oblongata, spinal cord, and sympathetic nerve, in one
hundred and thii'ty cases.

Of these one hundred and thirty cases, fifty -nine were
among the entirely successful cases.

Setons were employed in fifteen cases.

Of these fifteen cases, three were among the completely
successful cases.

These data go to show that the treatment which in my
hands has been productive of the best results, is that in
which one of the bromides, oxide of zinc, and the primary
galvanic current, were conjointly used.

In forty-three cases the bromide was productive either
of an injurious effect, or was without influence. The ma-
jority of these were nocturnal.

Five of these unsuccessful cases were subsequently treat-
ed with other remedies. One was cured by the lactate of
zinc ; one by changing the time for sleeping, and by the
administration of iron, quinine, and porter; and three by
strychnia, in small doses, as recommended by Mr. Tyrrel.

Of the one hundred and fifty-two cases in which the
bromide was only partially successful, four were cured by
strychnia.

I have not considered a case as fully cured till the pa-

586

CEREBRO-SPINAL DISEASES.

tient has been for six montlis without a fit after ceasing to
take medicine. In all, out of the two hundred and eighty-six
cases cited, seventj-four were of this category. Thus far
there have been, so far as my knowledge extends, but seven
relapses. In two of these the fits recurred ten months after
ceasing to take the medicines ; in two fourteen months ; and
in three fifteen months. In all of these the medicines were
at once resumed, and they are now under treatment. None
of these relapses have as yet been from the strychnia treat-
ment. My experience with this agent, though thus far sat-
isfactory, is not yet sufficiently extensive to warrant the
expression of a decided opinion as to its value when com-
pared with the bromides. I am inclined, however, to think
that it is more efficacious in the nocturnal form of epilepsy
than in the diurnal, and in the non-convulsive rather than
in the convulsive varieties. A point connected with the
treatment with the bromides must not be overlooked, and
that is the cachexia which so generally attends their admin-
istration in large doses. In a memoir,* published over two
years ago, and which has been cited in another connection,
I brought forward several cases in which this cachexia had
been produced. Greatly-increased experience has confirmed
the opinion there expressed, that it never causes any perma-
nently ill efiects, though I have frequently seen great consti-
tutional disturbance induced. In three cases large car-
buncles were caused, and in a few I have been obliged to
suspend for a time the administration of the medicine.

I am very sure that bromic cachexia is favorable to the
eradication of the epileptic tendency, and I therefore endeav-
or to produce it as soon as possible. It appears in many
cases to alter the whole organism of the patient to such an
extent as to leave him, when it disappears, with his nutritive
processes and his proclivities so modified that epilepsy is no
longer possible. The physician will require all his firmness

' On Some of the Effects of the Bromide of Potassium when administered
in Large Doses, Journal of Psychological Medicine, January, 1869, p. 46.

EPILEPSY.

587

and courage to persevere in those cases in which the bromism
is extreme. But he should not yield unless the phenomena
are so intense, and the strength of the patient so reduced, as
to excite his gravest apprehensions.

Five cases of epileptiform seizures, not included among
the cases cited, have been under my charge, in which there
was a decided syphilitic taint present. In these the bro-
mide of potassium was not administered to any considerable
extent, reliance being mainly placed on the iodide, given in
gradually-increased doses. In three cases the result is un-
known ; in two the treatment was entirely successful.

My experience with trephining is limited to one case,
in which the operation was performed by my friend Dr.
Yan Buren, It was unsuccessful, although there had been
an injury of the skull, to which we thought the paroxysms
might be due. In this case the bromide was only partially
successful. It is included among the cases previously cited.
The operation is, I think, entirely proper in cases ajjparently
the result of injury to the cranium, and several successful
instances are on record.

But, before resorting to any specific treatment for epi-
lepsy, diligent search should be made for the cause, and this
should be removed, if possible, without the least delay.
Often an eccentric irritation, such as worms in the intesti-
nal canal, implication of a nerve in an injury, disorders of
menstruation, etc., can be discovered, without the removal
of which a permanent cure is impossible. In several of the
cases cited, success in the treatment was in a great measure
due to acting on this principle.

The hygienic management of the patient is important.
A large portion of the day should be passed in the open air,
bodily exercise should be regular, but not excessive — the
food should be nutritious, but neither exciting nor indiges-
tible. The importance of avoiding every alimentary sub-
stance, calculated to cause gastric or intestinal irritation,
cannot be overestimated. I have frequently seen parox-

588

CEREBRO-SPINAL DISEASES.

ysms directly caused by nuts, dried fruits, pastry, heavy and
badly-baked bread, excess in the use of alcobolic liquors,
confectionery, and the like. The bowels must be kept
regular. Baths should be frequently taken, but should not
be so cold as to cause severe shock or physical depression.
Turkish baths, I am inclined to think, are useful in many
cases, particularly in those occurring in persons of full and
gross habit of body.

Overheated and ill-ventilated apartments should be
avoided. The clothing should be warm in winter and cool
in summer. The mind should not be overtasked and the
emotions must not be unduly excited.

Individual attacks may sometimes be prevented. One
gentleman under my charge assures me that he can often
dissipate the premonitory symptoms, and thus stop the de-
velopment of the paroxysm by a strong exertion of the will.
Another can arrest them sometimes by changing the posi-
tion of his body. If standing, he lies down ; if lying down,
he rises suddenly and paces the room violently. Another
stops them by putting salt in his mouth, and two can fre-
quently prevent them by tightening straps which I have in-
structed them to keep constantly around the wrist. In all
these cases there is an aura, and in the two latter it appears
to start from the hand.

A short time since I instituted, at the New York State
Hospital for Diseases of the Xervous System, a series of
experiments with the chloride of sodium in the treatment
of epilepsy, but, although the salt was given in large doses,
it produced no marked effect. I was led to these investi-
gations by the facts that the bromide of potassium, the bro-
mide of sodium, and the chloride of potassium, had been
employed with success, and I thought there was sufficient
analogy to warrant the hope that the chloride of sodium
might prove beneficial.

As regards other remedies for epilepsy, I have but little
to say. Belladonna has never in my hands produced the

EPILEPSY.

589

least effect, neither has digitalis, nor indigo, nor cotyledon
umbilicus, nor any of the salts of copper. I might say the
same thing of the other so-called remedies. Hydrate of
chloral in three cases mitigated the frequency of the parox-
ysms, but only for a short time. In several other cases it
was without effect ; Calabar bean was slightly beneficial in
one case.

The treatment during the paroxysm remains to be con-
sidered. It is simple, and, beyond a few obvious measures,
consists in letting the patient alone. The head should be
elevated, the collar and cravat loosened, a piece of soft wood
put between the teeth so as to prevent injury to the tongue,
and the patient so placed that he cannot fall or otherwise
injure himself in his struggles. During the subsequent stu-
por he should be kept quiet. Bloodletting is never neces-
sary, although it is recommended as proper in certain cases
by Jaccoud.

CHAPTEK III.

CATALEPSY.

Although there are no post-mortem appearances charac-
teristic of catalepsy, the phenomena of the disease observed
dm-ing life point to its seat in the brain and spinal cord.
Like epilepsy, therefore, it is a symptom representing an
unknown morbid change in the nervous centres.

Symptoms. — Catalepsy is an affection marked by the
occurrence of peculiar paroxysms at regular or irregular
periods. The seizures usually come on with suddenness,
and are characterized by more or less complete suspension
of mental action and of sensibility, and by the supervention
of muscular rigidity, causing the limbs to retain, for a long
time, any position in which they may be placed. The phe-
nomena, therefore, relate to the mind, to sensation, and to
motion.

The suspension of mental action is, in general, complete,
but in some cases there are an imperfect consciousness and an
ability to appreciate strong sensorial impressions. Thus, in
a case quoted by Dr. Chambers from Dr. Jebb — which, how-
ever, was clearly a case of catalepsy complicated with hys-
teria— the patient, before emerging from the paroxysm,
sang " tliree plaintive songs in a tone of voice so elegantly
expressive, and with such affecting modulation, as evidently
pointed out how much the most powerful passion of the
mind was concerned in the production of her disorder, as
indeed her history confirmed." ^

' Art. Catalepsy, in Revnolds's System of Medicine, vol. ii., p. 100.

CATALEPSY.

591

The aspect of a cataleptic patient is very striking. The
eyelids are sometimes wide open, at others gently closed ;
the pupils are dilated, and do not respond to strong light ;
the respiration is slow, regular, but generally so feeble as to
be perceived with difficulty ; the pulse is usually almost im-
perceptible, but is rhythmical and sluggish ; the face is pale,
the mouth is half open, and the rigidity of the body, and
the coldness of the extremities, add to the death-like appear-
ance which impresses all beholders.

The cutaneous sensibility is ordinarily completely abol-
ished. Pins may be stuck into the skin and they are not
felt ; but, owing to the abolition of the power of motion
and of reflex action, it is possible that in some cases, at
least, the patients would give evidence of sensation if they
could. Cases are on record in which tears have been caused
by excessive emotional disturbance excited by the words or
actions of persons surrounding the patients, thus showing
that the senses of sight and hearing were capable of being
exercised. Such instances are, however, rare, and are prob-
ably imperfectly-developed paroxysms, or those complicated
with hysteria or ecstasy.

The symptoms relating to the muscles are very remark-
able. Coming on, as the paroxysm usually does, without
warning of any kind, the patient is at once arrested in any
act which is being performed, and the whole body assumes
a condition of extreme rigidity. The power of the will over
the muscles is lost, and the limbs preserve any position in
which they may be placed by the by-standers. Thus, if the
arm be raised from the side, it remains extended, and may
keep this position for an hour or longer before it sinks slowly
back to its original situation. No matter how awkward or
irksome the position may be, it is retained till the exalted
irritability of the muscles becomes thoroughly exhausted.

The ability to swallow is not lost, and the electric con-
tractility of the muscles is not perceptibly affected one way
or the other.

592

CEREBRO-SPINAL DISEASES.

The paroxysm may last a few minutes or hours, or may
be prolonged to several days.

The temperature of the body, in all the cases that have
come under my observation, was reduced from two to four
degrees below the normal standard, and in the extremities
much more than this.

The paroxysm generally disappears with as much abrupt-
ness as marked its accession. A few deep inspirations are
taken, the eyes are opened, or lose their fixedness, the mus-
cles relax, and consciousness is restored. In fully-developed
seizures the patient has no knowledge of what has transpired
during the attack.

Seven cases of true catalepsy, uncomplicated either with
hysteria or ecstasy, have been under my professional care.
In two of these the seizures were more or less imperfectly
developed, and strong sensorial excitations were, in a meas-
ure, perceived and recollected after emergence from the
attack. But in every instance the character of the impres-
sion was misinterpreted. A bright light thrown upon the
eyes with a mirror was spoken of as an " angel's wing which
brushed across my face," and the scratch of a pin was re-
membered as " a piece of ice being drawn over the skin."

In these cases there was the consciousness of mental
action during the paroxysm, but it was difficult for the
patients to describe the thoughts which took place. They
appeared to be somewhat of the nature of dreams. In both
cases the muscular rigidity was well marked, but was not
excessive, and appeared to be mainly manifested in the ex-
tensors. It was not difficult to extend the arm or the leg,
but flexion required the exertion of a good deal of strength.

In the other five cases the paroxysms were completely
formed. Consciousness was entirely abolished; there was
no sensibility anywhere, and no reflex actions could be ex-
cited except those of deglutition. In one of these cases,
seizures several times occurred in my consulting-room, and
I had the opportunity of ascertaining the effect of electricity.

CATALEPSY,

693

If the arm was extended, the strongest induced current I
could apply to the biceps, though causing contraction, failed
to procure flexion, but relaxation of the extensors was at
once produced by the application to them of the primary
current.

I likewise, in this case, repeatedly examined the fundus
of the eye with the ophthalmoscope, and invariably found
the choroids pale, and the retinal vessels straight and atten-
uated.

In none of these cases was there any knowledge of what
passed during the paroxysms, and no consciousness of there
having been any mental activity.

Cataleptic persons are usually of dull and sluggish men-
tal and physical organization. Such has certainly been the
case in all the instances that have come under my observa-
tion. The disease does not ordinarily show any decided
tendency to become worse, either as regards the severity or
frequency of the paroxysms, provided the exciting causes
be avoided. On the contrary, there is often a well-marked
natural tendency to spontaneous cure, or, at least, to a cure
through the influence of purely hygienic influences, moral
as well as physical.

In the majority of cases catalepsy is complicated with
hysteria or ecstasy, and sometimes with epilepsy. Of this
latter combination I have seen two cases, and in one of these
ecstasy was also a feature. This case I have recently
alluded to in another communication.* The patient was a
young girl, was cataleptic on an average once a week, and
epileptic twice or three times in the intervals. Five years
previously she had spent six months in France, but had
not acquired more than a very slight knowledge of the
language — scarcely, in fact, sufiicient to enable her to ask
for what she wanted at her meals. Immediately before her
cataleptic seizures, she went into a state of ecstasy, during
which she recited poetry in French, and delivered harangues

' The Physics and Physiology of Spiritualism. New York, 1871, p. 55,
38

594

CEREBRO-SPINAL DISEASES.

about virtue and godliness in the same language. She pro-
nounced at these times exceedingly well, and seemed never
at a loss for a word. To all surrounding influences she was
apparently dead ; but she sat bolt upright in her chair,
staring at vacancy, and her organs of speech in constant
action. Gradually, she passed into the cataleptic parox-
ysm, in which she usually remained for from one to three
hours. Many cases of the combination of catalepsy with
hysteria and ecstasy have become celebrated in other rela-
tions than those of true science.

Causes. — Among the predisposing causes, sex is the most
efficient. All my cases were in females, and the instances
of the disease occurring in males are very rare. Heredi-
tary influence is likewise generally apparent. Of the seven
uncomplicated cases under my observation, all had relatives
affected with some well-marked disease of the nervous
system. In two cases, there were near relatives insane ; in
two, the mothers were hysterical; in one, a brother was
epileptic ; in one, the father was similarly affected ; and, in
one, a sister was cataleptic. It rarely begins after the age
of twenty-five. Of exciting causes, emotional disturbance
stands first. Four of my cases were directly the result
— one of fright, one of anger, one of grief, and one of the
shock caused by a boy starting out suddenly from behind a
door where he had been concealed. In one other case, the
cause was worms in the intestinal canal ; and, in the other
two, I could not ascertain with certainty what the cause
was, though I had strong reasons for suspecting it to be
masturbation.

The diagnosis is not a matter of the least difficulty to
any one who has even an imperfect knowledge of the phe-
nomena, except, perhaps, as regards its discrimination from
hysteria, that simulator of almost every nervous disease.
In those cases complicated with hysteria, the distinction is
of no importance ; in others, the uniformity of the charac-
teristics which indicate catalepsy, with a consideration of

CATALEPSY.

595

the general history of tlie case, will serve to make the diag-
nosis sufficiently precise. It must, however, be borne in
mind that the two diseases are near of kin, and that the
discrimination is important more as a matter of abstract
science than as one of any bearing on the therapeutics. It
is, however, sometimes a matter of moment to distinguish
between the c£>.taleptic paroxysm and death. In former
times, instances were not uncommon in which the mistake
was made, to be discovered after life had really become
extinct in the coffin. Such fatal errors would probably be
impossible now with the stethoscope for examining the
heart, the thermometer for determining the temperature,
electricity for acting on the muscles, and, above all, the
ability to place the limbs in positions which they maintain
against the laws of gravity. Moreover, our knowledge of
diseases in general is such as to enable us to determine with
great certainty the course they are liable to take, and the
manner in which death occurs in each.

Prognosis. — This is usually favorable, even in severe cases.
All my patients recovered under the treatment to be pres-
ently mentioned.

There is scarcely any thing to say under the head of
morbid anatomy. It has been stated * that, in the few cases
in which post-mortem examinations have been made of
persons dying while cataleptic or subject to seizures, the
Pacchionian bodies were found enlarged, but I have been
unable to trace the assertion to its source.

The pathology of catalepsy is very imperfectly known.
The symptoms show that the brain and spinal cord are
involved, and there is some evidence to show that they are
in a state of ansemia. But there is a condition induced in
these organs which is the essential feature of the disease,
and of this we know nothing. There is a possibility that
the affection may be a masked form of epilepsy, and this

' Art. " Catalepsie " in Nouveau Dictionnaire de Medecine et de Chirurgie
pratiques, t. sixieme, p. 456. Paris, 1867,

596

CEREBRO-SPINAL DISEASES.

view is borne out hj the fact that the treatment which is
most successful in this latter disease is most efficacious in
catalepsy.

Treatment. — The bromide of potassium, or one of the
other bromides previously mentioned under the head of
epilepsy, is the most efficient agent in the treatment of
catalepsy. I have never yet failed to cure the disease with
this remedy, combined with the oxide of zinc, and with the
simultaneous use of strychnia and other tonics. I have
never, however, had occasion to give it in larger doses than
twenty grains, three times a day, or to continue it beyond
eight months.

In no disease of the nervous system, not even excepting
hysteria, is it more necessary that the mind should be
brought under proper discipline and kept as far as possible
from the operation of all causes calculated to promote emo-
tional excitement. At the same time a well-regulated sys-
tem of hygiene, as regards all the physical requirements of
the body, is indispensable.

CHAPTER IV.

ECSTASY.

Though closely allied to catalepsy, ecstasy differs from
it in several important particulars. One of the main points
of difference is that the patient recollects the train of
thought which has been going on during the seizure, and
this of itself is sufficient to warrant their being separately
considered. It often happens, however, that the two dis-
eases alternate or coexist.

Symptoms. — In ecstasy there is muscular immobility rath-
er than rigidity ; the eyes are open, the lips parted ; the
face is turned upward, the hands are often outstretched; the
body is erect and raised to its utmost height. A peculiar
radiant smile illumes the countenance, and the whole aspect
and attitude is that of intense mental exaltation.

The mind is so filled with some particular train of
thought, that excitations of the senses, if of moderate
intensity, are not perceived. We meet with this fact often
in normal conditions, when the mind is deeply engaged in
reflection, or when it is engrossed with some powerful emo-
tion.

Most of the religious impostors who have at various"
times made their appearance, and many very sincere and
devout persons, have been ecstatics.

In its combinations with catalepsy, chorea, and hysteria,
ecstasy has frequently played an important part in the his-
tory of the civilized world — at one time, leading to a be-
lief in witchcraft ; at another, to demoniac and angelic pos-

598

CEREBRO-SPINAL DISEASES.

session ; at another to mesmerism and clairvoyance ; and,
in our day, to spiritualism. The consideration of these fol-
lies, though interesting, scarcely comes within the scope of
the present treatise.

Causes. — Ecstasy, though not entirely confined to the
female sex, is very much more common in women than in
men. It appears to be produced in those who are of deli-
cate and sensitive nervous organizations by intense mental
concentration on some one particular subject — ^generally,
one connected with religion, or some other abstract train of
thought. It was formerly quite common among the in-
mates of convents, and is now not unfrequently met with
at camp-meetings and spiritualistic gatherings.

There are no points about the diagnosis requiring special
consideration, and the prognosis is always favorable, if the
subject can be submitted to proper moral and physical
treatment. As the disease is never fatal jper se^ we know
nothing of its morbid anatomy. The pathology, as indicated
by the symptoms, points to the implication of both the
brain and spinal cord, but there is no satisfactory theory
of the disorder other than that which refers it to cerebral
and spinal preoccupation — a kind of setting of the current
in one direction, whereby all other occupation is for the
time prevented.

Treatment. — The means of treatment, though not differ-
ing essentially from those proper for catalepsy, require,
nevertheless, special mention of some particulars. The in-
fluence of moral force in preventing and curing ecstasy is
well marked, and many instances are on record in which
epidemics of it have been arrested by arguments addressed
to the fears of the subjects. I have several times aborted
and prevented ecstatic manifestations by making prepara-
tions to cauterize the region of the spine with a red-hot
iron.

A great deal can be done by giving as little notoriety to
ecstatics as possible. They glory in the idea that they are

ECSTASY.

699

of sufficient importance to excite attention and discussion,
and thej are accordingly stimulated to continue their per-
formances so long as they are noticed, and an air of mystery
is attached to them.

Eemoval from all associations calculated to continue the
exciting and morbid train of thought which has developed
the disease under notice should, of course, be a point in the
treatment.

Electricity, and the other measures of treatment recom-
mended for catalepsy, will prove serviceable in ecstasy. By
galvanization of the sympathetic nerve, I, on one occasion,
immediately cut short a paroxysm of ecstasy, and, by con-
tinuing the practice every alternate day for about six
weeks, effectually cured the patient, who for several years
had been subject to seizures every two or three days.

CHAPTEE Y.

CHOBEA.

Although it is quite certain that several distinct affec-
tions are included under the term " chorea," these are analo-
gous to each other, and, as we know little about the essen- .
tial anatomical features of these disorders, and as they are
allied by their symptoms, it will be advisable, for the pres-
ent, to consider them together.

Symptoms. — Even in simple typical and uncomplicated
cases of chorea, the symptoms exhibit great variety. They
are connected mainly with the mind, with motility, and
with sensibility, though, at the same time, the functions of
organic life are generally more or less deranged.

Among the earliest symptoms of chorea are those refer-
able to disordered brain-action. The character and* disposi-
tion of the patient undergo a marked change, and there is,
besides, from the first, a very decided impairment of mental
vigor. The emotions are easily excited, and the temper
becomes fretful and irritable. Hallucinations are not un-
common, and these are generally connected either with
the sight or hearing. Sometimes both these senses are in-
volved.

The sleep is generally disturbed by disagreeable dreams,
sometimes reaching to the intensity of nightmare, and these
are so vivid that the patient often considers them realities.

In a few cases, there is decided mania, but this is not of
a very aggravated form, and is of temporary duration.
Three such instances have recently been under my care, all

CHOREA.

601

occurring in young girls of about the age of puberty, and
exhibiting in all other respects the typical characteristics of
chorea.

In two cases under my observation, the first notable
event in the course of the disease was an epileptic parox-
ysm, which, however, was not repeated in either case.

The most prominent symptoms of the disease are, in
the great majority of cases, exhibited in the irregular and
disorderly muscular contractions which make their appear-
ance at a very early period, and which have given it a name
in nearly every language of the civilized world. Thus, we
have the terms chorea (^opeia, a dance), St. Vitus's dance,
St. Guy's dance, etc.

In the beginning the foot of one side drags a little, and
soon afterward the corresponding upper extremity becomes
affected with the choreic movements. These are manifested
in the fingers, in the flexion, extension, and rotation of the
wrist, and in the movements of the elbow and shoulder.
No matter where the hand be placed, it cannot be kept
steady, but it and the whole extremity are in a constant
state of agitation. Before long the muscles of the neck and
face participate, the head is jerked from side to side, and a
continual series of grimaces is the result of the actions in
the facial muscles.

In some cases the involuntary movements are confined
to one lateral half of the body, constituting the form known
as hemichorea. This is the case in about one-fourth of the
cases. Thus, of two hundred and thirty-five cases cited by
See,^ the phenomena in sixty-four were limited to one side.
This limitation has not, as was formerly supposed, any rela-
tion with hemiplegia, but is solely the result of the suspen-
sion of the progress of the disease.

At first the movements are moderate, but they go on, be-

1 De la choree et des aflfections nerveuses en general, avec leurs rapporta
avec les diatheses, et principalement avec le rheumatisme. Mem. de rAcademie
de Medecine, 1850, t. xiv., p. 343, et seq.

602

CEREBRO-SPINAL DISEASES.

coming more and more severe, until, in extreme cases, the
condition of the patient becomes exceedingly pitiable. The
arms, the legs, the face, and head, are in almost constant
action. Every attempt to perform a voluntary movement
excites still more the disorderly actions, and thus the patient
is unable to feed or dress himself, and sometimes even walk-
ing becomes impossible.

In one type of cases the convulsive movements come on
paroxysmally, and are often of the most astonishing charac-
ter. The patient is, perhaps, lying quietly on the bed, when
suddenly the head is thrown backward, the limbs set in in-
voluntary motion, and the muscles of the trunk contract
so violently as to throw the suffferer forcibly to the floor.
Again, a series of gyratory motions ensues, and the patient
turns round on one foot until complete exhaustion follows ;
or there may be leaps and contortions of various kinds.
Sometimes the movements are rhythmical. A lady, who a
short time since was under my charge, was suddenly seized
with an irresistible impulse to bend the left elbow. The
arm continued in motion for half an hour, and then the
right arm began a like movement. In a few minutes the
head began to nod, then the left knee was alternately flexed
and extended, and finally the right knee became similarly
affected. For over an hour these movements continued,
and then a regular alternation ensued — first the left arm,
then the right, then the head, next the left leg, and finally
the right leg. These actions were perfectly timed, and
were all performed in exactly ten seconds, as I ascertained
by determinations made on several occasions. As she sat
in a chair, or lay on a bed, she was a curious sight. Though
she was good-tempered with it all, her emotional system
was in a state of great exaltation. She recovered in a few
weeks.

In another case a lady from New Jersey was aifected in
a still more extraordinary manner. "While sitting sewing
one day, after having been greatly fatigued the previous

CHOREA.

603

night, her leg began to tremble violently. In a few minutes
the arm of the same side became involved, and very soon
the other limbs and the head were afiected. She was now
in a state of general tremor, and, on attempting to rise, fell
to the floor. She was then seized with another kind of
movement. Her legs were drawn up forcibly, and then
suddenly extended, and this with inconceivable rapidity.
She was placed on a bed, but was unable to stay there un-
less held by several persons, so strong were the contractions
which took place. On one occasion she was thrown over
five feet, her body coming to the floor with great violence.

The following day a fresh series of phenomena ensued.
She began to turn somersets, and continued these actions
for several hours without appearing to be greatly exhausted.
Then she jumped suddenly to her feet, and rushed round in
a circle with such swiftness that she could not direct her
steps, and she several times knocked her body with great
force against the walls and furniture. Then she danced for
several hours, and toward evening became tolerably quiet,
though there was still involuntary twitching of nearly all the
muscles. In all the various movements she went throuo'h.
every attempt to hold her only made her worse, and she
begged that she might be let alone, as the effort to control
her by physical force made her head swim, and gave her a
severe headache. At night the paroxysms ceased, but they
were renewed as soon as she awoke in the morning, and
continued with but little intermission, and in every possible
form, till she went to sleep.

On the third day I visited her, and found her in the
midst of a series of movements such as I have described.
Her pulse was irregular, her respiration hurried, and her
countenance evinced great anxiety. There was no evidence
of any hysterical complication.

I at once proceeded to administer chloroform by inhala-
tion, and in a few moments she was completely under its
influence. The paroxysms ceased soon after the inhalation

604

CEREBRO-SPINAL DISEASES.

was begun. I kept her in a state of anaesthesia for half an
hour. When she recovered consciousness she was perfectly
composed, and remained so all the rest of that day. I left
directions that the inhalation was to be repeated if there
should be any return of the choreic paroxysms, but there
were none. She slept well all night, and the following
morning was quiet till about eleven o'clock, when a slight
tremor began, which was at once quieted by the chloroform.
I saw her again that day, and began a treatment consisting
mainly of strychnia in gradually-increasing doses, and re-
newed my directions in regard to the chloroform. After
this she had a few attempts at paroxysms, but they were
always stopped by the inhalation of the chloroform, and in
a few weeks she was well.

Chorea of rhythmical or uniform character has often pre-
vailed epidemically. The most authentic recorded visita-
tion of the kind was one which occurred at Aix-la-Chapelle
in 1374. This was in the form of a dancing mania, and is
fully described by Hecker' under the name of St. John's
Dance. The men and women subject to it met in the
streets and churches, where " they formed circles hand-in-
hand, and, appearing to have lost all control over their
senses, continued dancing, regardless of the by-standers, for
hours together in wild delirium, until at length they fell to
the ground in a state of exhaustion. They then complained
of extreme oppression, and groaned as if in the agonies of
death, until they were swathed in cloths bound tightly
around their waists, upon which they again recovered, and
remained free from complaint until the next attack. This
practice of swathing was resorted to on account of the
tympany which followed these spasmodic ravings, but the
by-standers frequently relieved patients in a less artificial
manner, by thumping and trampling upon the parts aifected.
"While dancing they neither saw nor heard, being insensible
to external impressions through the senses, but were haunt-
' Epidemics of the Middle Ages. Sydeniiam Society Translation, 1844, p. 87.

CHOREA.

605

ed by visions — their fancies conjuring up spirits, whose
names thej shrieked out ; and some of them afterward as-
serted that they felt as if they had been immersed in a
stream of blood, which obliged tliem to leap so high. Oth-
ers, during the paroxysm, saw the heavens open and the
Saviour enthroned with the Virgin Mary, according as the
religious notions of the age were strangely and variously re-
flected in their imaginations."

In the most fully-developed and best-marked instances
of the disease, it was often ushered in by an attack of epi-
leptic convulsions.

The afiection spread like wild-fire — being fed by that
principle of imitation which appears to be so powerful an
influence in causing the propagation of this and analogous
disorders of the nervous system. Those afiected were gen-
erally regarded as being possessed by evil demons, and con-
sequently only to be cured by the exorcisms of the clergy.

In 1418 it broke out in Strasbourg, and there received
the name of St. Yitus's dance, from the fact that the most
efficacious means of cure was thought to consist in the inter-
cession of this saint.

Similar attacks of dancing mania had occurred before
that of St. John, but the details are more or less obscure,
and several have occurred since. Among these latter must
be placed the tarentism which overran Italy, and various
more restricted epidemics of like disorders. In our own
country we have had the J umpers, and we still have the
Shakers. In addition to these are many of the manifesta-
tions of witchcraft, which were choreic, and of which this
country has had its full share, and of spiritualism, which it
enjoys the doubtful honor of having initiated.*

In chorea, even of the ordinary simple kind, the speech
is imperfect, owing to the incoordination of the musclq^
directly concerned in articulation, and those which effect

' See the author's " Physics and Physiology of Spiritualism " for more com-
plete details on this and analogous subjects, and for accounts of other examples.

606

CEREBRO-SPINAL DISEASES.

respiration. There are therefore stuttering and stammer-
ing, and at times a peculiar difficulty of speaking, owing to
the attempt being made when the chest is empty ; that is,
when expiration has first been accomplished. The tongue
and lips rarely escape being involved to a considerable ex-
tent.

The muscles of mastication and deglutition are gener-
ally affected, and hence the food is imperfectly chewed, and
often causes choking from difficulty of swallowing it.

In some cases chorea is accompanied with paralysis —
the chorea paralytica of authors. This loss of the power
of voluntary motion is usually hemiplegic, and involves the
same muscles, which are the seat of the irregular move-
ments. Occasionally there are contractions of the limbs,
but not to any great degree.

Chorea is sometimes of very limited extent. It may be
only shown in the hand or foot, but more frequently, when
restricted in its topography, it is manifested in the head or
face. There may be only a little twitching of the muscles
at the angles of the mouth, or of those which raise the upper
lip, or of the orbicularis palpebrarum, by which the eyelids
are closed, or of the levator palpebrae superioris, or of the
corrugator supercilii, or occipito- frontalis. Sometimes the
head is rotated suddenly, or twitched to one side, or there is
a shrugging of the shoulders.

In several cases that have been under my care, the ab-
normal manifestations were entirely confined to the organs
of voice or speech. In one instance — that of a young girl
from Illinois — while there was a general hypergesthesia of
the whole nervous system, there were no choreic movements
except of the respiratory and laryngeal muscles. The res-
piration was therefore exceedingly irregular, and at times
Uiarticulate sounds were made, which were involuntary.
Articulate speech was lost from inability to coordinate the
muscles, but there was no paralysis, for the tongue could be
moved freely in all directions, and the lips were as mobile

CHOREA.

607

as ever, except when the patient made an effort to speak.
After a few weeks the sound from the larynx was made
regularly at each expiration. There were no sounds during
sleep.

In this case there was a strong hysterical element pres-
ent. The affection resisted all treatment, and finally I sent
the patient home, scarcely improved except in her general
health. One morning she awoke, began to speak, and there
was no resumption of the laryngeal sounds. She has con-
tinued well ever since, now over two years.

Again, there may be an irregular action of the muscles
of speech, and in consequence words are uttered against the
will of the patient, and often without any previous knowl-
edge of what is going to be said. Several such cases have
been under my observation, and I have alluded to two of
them in a recent lecture' on chorea. Since then another
remarkable case of the kind has come under my care. In
this instance there is scarcely a minute during the day that
the speech is not going on, and this without the least power
on the part of the patient to arrest or direct it. If he is
asked a question, he can only use a few apposite words, the
others being altogether without relation to the subject about
which he wishes to speak.

The convulsive movements in chorea almost invariably
stop during sleep. They are also sometimes temporarily
arrested by intense mental occupation, but are always ren-
dered worse by emotional disturbance or physical fatigue.
On the contrary, they are diminished by mental and emo-
tional quietude.

Strange as it may appear, the sensation of being tired is
scarcely ever experienced by choreic patients. Generally,
however, there are wandering pains in the limbs, headache,
and pain in the back. The cutaneous sensibility is usually
increased, but in some cases it is greatly lessened, and may
be abolished altogether in some parts of the body.

> Journal of Psychological Medicine, January, 1871, p. 51.

608

CEREBRO-SPINAL DISEASES.

The functions of the several viscera are ordinarily more
or less deranged. There are paroxysms of palpitation of
the heart, and the action of this organ is to some extent
irregular during the whole course of the disease. Endocar-
dial murmurs are often present, either systolic or diastolic,
but are the result of the anaemia vs^hich is so prominent a
feature of chorea. Respiration is imperfect ; the stomach
does not digest well ; and there are nausea and vomiting.
The bowels are constipated ; the urine is loaded with phos-
phates, and is of diminished quantity ; and the menstrual
function in girls is imperfectly performed, either as regards
quantity or quality. The skin is dry and harsh, the hair
loses its gloss, the complexion is pale, the lips bloodless, the
pupils dilated, and the sclerotic coat of the eye of more
than normal whiteness.

The tendency of chorea is to increase to a certain point,
and then to gradually diminish. In favorable cases occur-
ring in children, it runs its course in about three months.
This period can be materially shortened by appropriate
treatment. Sometimes, it ceases very suddenly, and, in
others, passes into a chronic condition, which may last for
years or during the life of the patient. Occasionally, it
terminates in death, either directly or in consequence of the
supervention of some intercurrent affection. Three fatal
cases have come under my observation. One of these I
saw several times in consultation with my friend Dr. T. G.
Thomas. The patient was a young lady about twenty
years of age, and her paroxysms were of the most violent
character, sometimes being so strong as to cause her to
throw herself off the bed, or to dash about the room with
great force. 'No treatment appeared to exercise any re-
straining effect, and, after about two years, she died of an
abdominal affection. There was no post-mortem examina-
tion. In the other two cases, death ensued from exhaus-
tion.

Relapses are common in chorea, especially in children,

CHOREA.

609

and sometimes as many as half a dozen attacks occur.
Subsequent seizures are usually less severe than the first.

Chorea is often complicated with hysteria — a combina-
tion which will be described hereafter. It may also exist in
conjunction with rheumatism and malarial fevers, and the
exanthemata. ,

Causes. — Chief among the predisposing causes of chorea
is age. It is more frequent during the period extending
from six to fifteen years than during all the rest of life.
See, of five hundred and thirty-one cases, found four hun-
dred and fifty-three of ages ranging from six to fifteen years.

Of eighty-two cases, occurring in my own experience,
sixty-seven were of ages between six and fifteen years.
Under the age of six, the disease is less frequent as we go
toward birth. Cases have been met with in infants at the
breast of six months old. The youngest case I have had
was a girl of eighteen months.

After fifteen, the disease, unless it occurs as an epidemic,
is not very common. Cases are, however, met with in
adults, and even in very old persons. I have seen four
cases in individuals o\'er thirty and three in persons be-
tween the ages of twenty and thirty. Of course, I refer to
the origination of the disease at these ages: instances of
its beginning in childhood, becoming chronic, and lasting
through life, are not so rare. In those cases reported by
authors of the affection originating very late in life, we
have every reason to conclude that they were instances
of organic lesions of the brain or spinal cord — probably,
sclerosis — giving rise to rhythmical movements or paralytic
tremor.

The female sex is much more liable to chorea than the
male. Of See's five hundred and thirty-one cases, three
hundred and ninety-three were girls and one hundred and
thirty-eight boys.

Of my eighty-two cases, seventy were females and twelve
males. Eheumatism has been supposed to be a predispos-
39

610

CEREBRO-SPINAL DISEASES.

ing cause of chorea. Of one hundred and twenty-eight
cases, See found sixty-one in association with rheumatism,
but, when we come to inquire further, we find that only
thirty-two of these were articular rheumatism, while the
rest were cases in which there were wandering pains which
may have been, and probably were, without the least affinity
with true rheumatism.

While it is certainly the case that chorea sometimes fol-
lows or exists coincidentally with rheumatism, I doubt if its
influence is any more than that of a depressing agent to the
organism. Of the eighty-two cases observed by myself,
only sixteen were connected with rheumatism, while eigh-
teen were just as intimately related to other diseases.

The affection appears to be more common in winter than
in summer. Of my cases, fifty-four occurred in the six
months from October to March, and twenty-eight in the
other six months of the year.

Among the exciting causes, those connected with the
emotions occupy the first place. Twenty-seven of my cases
were directly the result of fright, apprehension, anxiety,
mental excitement, or some other cause of the kind. In eight
it was induced by intense study at school, and in four from
imitating others similarly affected. This latter factor is not
of so general application as in former times, when social life
was different. To it is doubtless to be ascribed the spread
of choreiform movements through certain localities, and
especially convents, such as occurred in the thirteenth, four-
teenth, and fifteenth centuries, to some of which reference
has already been made.

Among other causes, bad hygienic influences and ex-
hausting diseases generally are to be mentioned.

Pregnancy is also asserted to be a cause, and cases are
on record in which the foetus has been born choreic of a
choreic mother.

Diagnosis. — There is not much danger at the present day
that chorea will be confounded with many of the diseases

CHOREA.

611

from whicli, not long ago, it was not clearly disassociated.
Thus from paralysis agitans, epilepsy, locomotor ataxia,
cerebral and cerebro-spinal sclerosis, the fuller acquaintance
which we have in recent years acquired of these maladies
prevents the necessity of dwelling on their characteristics
as distinguished from those of chorea. The course of the
latter disease and the symptoms, other than those connected
with motility, are in the others so different that no one who
has studied their phenomena could fail in making a correct
diagnosis.

With hysteria, some of the forms of chorea may be con-
founded, and the two affections are not infrequently blended
in the same person. It must be confessed, too, that there
are cases in which the diagnosis cannot be clearly made out.
So far as the patient is concerned, the difficulty of forming
a correct opinion in such cases is not a matter of much mo-
ment.

The great majority of cases of chorea, such as are met
with in children, are readily distinguished from hysteria.
The facts of the disease occurring before puberty in so large
a proportion of instances, that the emotional system is
rarely disturbed as in hysteria, that the affection is not so
paroxysmal, and that the accessions of hysteria are more
sudden, will be sufficient to render the diagnosis accm-ate.

Prognosis. — This is usually favorable in those cases which
occur before puberty. The chorea of adults is, however, in
most instances, a very unmanageable affection, and gener-
ally either terminates in death or becomes permanent.
Cases in which death has ensued have been reported by
various authors — among them, Dr. John W. Ogle,' Dr. J.
Hughlings Jackson,* and Dr. G. See.' As already stated,

* Remarks on Chorea Sancti Viti, including the History, Course, and Termi-
nation of Sixteen Fatal Cases, etc. British and Foreign Medico-Chirurgical
Review, January, 1868, p. 208.

2 The Physiology and Pathology of Hemi-Chorea. Edinburgh Medical
Journal, October, 1868. ^ Op. cit.

612

CEREBRO-SPINAL DISEASES.

three fatal cases have occurred in my own experience. T]ie
tendency, however, in the chorea of young persons is decid-
edly toward recovery, even under unfavorable circumstances
as regards hygiene or medical treatment.

Morbid Anatomy and Pathology. — In many cases of persons
dying, either from chorea or from intercurrent affection, no
changes have been found which could, with probability, be
regarded as constituting the disease. In other cases, mor-
bid alterations from the healthy state have been found.
The idea has, therefore, prevailed that there are two kinds
of chorea — one which is entirely functional, belonging to
the so-called neuroses, the other the result of organic disease
of the brain or spinal cord, or both. In Ogle's sixteen fatal
cases, congestion of the brain and its membranes was found
in some, while in others the difficulty existed in the spinal
cord.

In an analysis of one hundred cases of chorea, Dr.
Hughes ' cites fourteen fatal cases. In all but four of these
there was intra-cranial congestion with other structural
changes, such as softening, opacities and adhesions. The
spinal cord was not examined in six cases. Of the remain-
ing eight, it was healthy in three, and congested, softened,
or with adhesions or opacities of the membranes in the re-
maining five.

In seven fatal cases, collected by Romberg," there were
softening and degeneration of different parts of the brain
and of the spinal cord.

Other similar cases have been reported, and in the ma-
jority there were fibrinous concretions on some portion of
the heart's valves or lining membrane.

In 1850 and 1863, Dr. Senhouse Kirkes ' published the
details of a number of cases which went to show the asso-

' Digest of One Hundred Cases of Chorea. Guy's Hospital Reports, vol. iv.,
1846, p. 360.

2 Lehrbuch der Nervenkrankheiten, B. ii.

3 London Medical Gazette, 1850, and Medical Times and Gazette, 1863.

CHOREA.

613

ciation between chorea and rlieuinatisni, and he made the
prediction that " future experience will still more positively
demonstrate that an affection of the left valves of the heart,
with the presence of granular degeneration upon them, is
an almost invariable attendant upon chorea, under whatever
circumstances the chorea may be developed." The relation
is also insisted upon by See and other authors, and such
cases as those of Ogle are cited in its support. But the
doctrine is only applicable, with any probability, to the fatal
cases, and, in those of Ogle, rheumatism was not always an
antecedent. In regard to this point, I am entirely in accord
with the views expressed by Dr. Ogle in the following ex-
tract, which I make from his valuable paper :

" Again it miglit be asked, if there was merely a me-
chanical cause (which, of course, would be constant in
operation), such as embolism, why should the movements
be so decidedly and universally interrupted during quiet
sleep ? Or, why should certain peculiarities as to age or sex
be considered as predisposing influences ? Recognizing the
frequent existence of these fibrinous deposits, or granula-
tions on the heart's valves in chorea, I should be much
inclined to look upon these post-mortem appearances rather
as results of some antecedent condition of the blood, common
also to the choreic condition. It is very freely recog-
nized that this affection is frequently in some way or other
connected with that condition of blood which obtains in
what we call anaemia, or that existing in rheumatic con-
stitutions. In both of these states we know that the
fibrine of the blood is much in excess (as also it is in preg-
nancy and other conditions looked upon as obnoxious to
chorea), and in these states we know that the fibrine (with
which the blood is surcharged) is very prone to be readily
precipitated, either owing to its superabundance or from
other obscure and acquired properties (possibly also from
some interference with the relation of the fibrine and the
other constituents of the blood), upon the heart's walls or

614

CEREBRO-SPINAL DISEASES.

valves. May not this lijperiiiosis be the explanation of the
coincidence alluded to ? In most cases, the deposit is
probably very slight, and, in many cases, so slight as to
require search for it. May it not infrequently be that it is
often only found in quite the dying state ? Speculation
might suggest that the fibrinous deposits arise from some
interference with the degree of solubility of the fibrine,
induced by the presence of some ununited elements within
the blood (some result of tissue-metamorphosis) produced
by the excessive muscular action and other functional dis-
turbance which exists in the choreic state, thus being not
in any way related to this state as a cause, but as a conse-
quence."

In the paper to which reference has already been made,
Dr. Hughlings Jackson associates hemi-chorea with the
plugging by emboli of the vessels of the corpus striatum of
one side, and, in a recent valuable paper. Dr. Charlton Bas-
tian ' says :

" I need only hint at the important bearing which the
possibility of the occurrence of minute embolisms of this
kind may have in the elucidation of previously-obscure forms
of so-called functional disease of the nervous system, as I
hope shortly to publish the details of a fatal case of chorea,
in which such embolisms led to ruptures and obliterations
of small vessels throughout the corpora striata and in the
course of the middle cerebral arteries generally — this be-
ing a case of bilateral chorea in which delirium was also
present."

As the result of our present knowledge of the morbid
anatomy of chorea, while it cannot be said that we are able
to define its seat with accuracy, we have strong evidence to
support tlie view that it is not a neurosis or functional aficc-
tion — if, indeed, there are any such — and that it is the re-
sult of changes taking place in the cerebro-spinal system.

' On the Plugging of Minute Vessels in the Gray Matter of the Brain, etc.
British Medical Journal, January 30, 1869, p. 96.

CHOREA.

615

As previously stated, I am inclined to think that there are
at least two distinct diseases — one due to spinal and the
other to cerebral lesion — the latter probably consisting of
several forms — but that it is advisable to consider them as
one disease of various types, until further investigation en-
ables us to speak with certainty on the subject, and to clas-
sify them according to the morbid anatomical condition of
each.

Treatment. — Diseases which are almost certain to termi-
nate fatally, and those which ordinarily recover without
medical treatment, are very sure to have a great many
medicines used in their therapeutics. Chorea belonging, as
it does, to this latter category, has a medical armamentarium
almost equalling that of hydrophobia. I shall, of course,
not even pretend to mention all these measures, but will
merely cite those which the weight of evidence, and espe-
cially that derived from my own experience, indicates as the
most effectual. Of the benefit to be derived from proper
medical treatment in shortening the duration of the disease,
and preventing chronicity, 1 have no doubt.

In this country zinc is probably more used in chorea
than any other single remedy. I have employed it in many
cases, and sometimes with good results. My prefei*ence is
for the sulphate, w^hich I give in gradually-increasing doses,
from two or three grains up to twenty or thirty three times
a day, dissolved in a sufficient quantity of water, to prevent
gastric irritation. When the choreic symptoms begin to
disappear, the doses should be diminished in the same grad-
ual manner in which they were increased.

Iron is also frequently administered as a sole remedy,
and still more generally as an adjuvant. Indeed, no matter
what special treatment may be adopted, iron is generally
indicated to improve the quality of the blood. I rarely use
it unless for this latter purpose.

' Arsenic enjoys a high reputation in the treatment of
chorea, and by some is regarded as almost a specific. Al-

616

CEREBRO-SPINAL DISEASES.

thougli I have several times given it with great advantage,
I have repeatedly had it fail in my hands. I have admin-
istered it twice hypodermically for choreic movements in-
volving the muscles of the neck, as recommended and suc-
cessfully used by Dr. Kadcliffe. In one of these it failed,
but in the other it was thoroughly effectual. Five minims
of Fowler's solution, diluted with an equal quantity of
water, were injected into the cellular tissue immediately
over the belly of the left sterno-cleido-mastoid muscle, the
muscle which was affected. The following day six minims
were injected, and so on till the quantity reached ten min-
ims. By this time the jactitations had nearly ceased, and
a few more injections of ten minims each were sufficient to
render the cure complete. In this case zinc, electricity in
the forms of the primary galvanic, and induced currents,
iron, morphia, and several other measures, had failed.

Tartarized antimony, copper, sulphate of aniline. Cala-
bar bean, and various other substances, have been employed
with more or less success, according to reports, but I have
no personal experience of their value.

I have used both the primary galvanic and induced cur-
rents in sixty cases. In my opinion they are inefficacious
except in that form in which there is distinct paralysis.

Without stopping to detail other means, I will describe
the modes of treatment which my experience has convinced
me are most efficacious. As one of the remedies, I usually
administer the bromide of potassium or sodium in moderate
doses, so as to render the sleep sounder. I do not regard
this as an essential part of the treatment, and, if the patient
is exceedingly anaemic, I do not urge it.

My main reliance is on strychnia, which I think should
be given in gradually-increasing doses, somewhat after the
manner recommended by Trousseau. Two grains of the
sulphate of strychnia are dissolved in an ounce of water,
and for a child of from ten to fifteen years of age five mih-
ims should be given three times a day. This quantity rep-

CHOREA.

617

resents the one forty-eightli of a grain of the salt. The
following day six minims are administered at each dose, the
next seven, the next eight, and so on till the physiological
effects of the medicine, as evidenced by stiffness of the legs
and neck, are obtained. Sometimes these are not perceived
till twenty or twenty-five minims are taken at a dose. In
other cases they follow on doses of ten minims. When they
take place, the doses should be at once reduced to the origi-
nal five minims, and the increase carried on as before. This
plan of treatment certainly shortens the duration of the dis-
ease very materially, and causes great improvement in the
general health of the patient. Sometimes the effect is so
well marked, and is so immediate, that it is not necessary to
increase the doses to the extent of causing muscular cramps,
but generally the full therapeutical effect of the drug is not
obtained till the calf of the leg, or the nucha, has slight tonic
spasm. I have never seen the slightest ill consequence fol-
low this mode of treatment, and the doses are increased so
gradually that with careful watching danger need never be
apprehended. I have carried it out in thirty-two cases
occurring in children under the age of fifteen, and in three
cases in persons of adult years, without a single failure.

In one of the latter the affection was limited to the
speech, there being an inability to utter words in accord-
ance with the ideas. In this case the dose was increased to
thirty-five minims before any rigidity of the legs was per-
ceived, and then the command over the language began to
appear, and by continuing the doses at thirty-five minims
the patient was entirely cured within a month. In this case
the initial dose was ten minims.

Quite recently I have made use of the ether-spray to the
spine as employed by Lubilski, Zimberlin, and others, and
my success has been unequivocal. The whole spine is ex-
posed, and the ether is thrown upon it from the occiput to
the sacrum for about ten minutes every day, or every alter-
nate day, according to the severity of the attack. Ten

618

CEREBRO-SPINAL DISEASES.

applications are the maximum number I have found it
necessary to make, and thus a cure has always been ob-
tained within two weeks. I have employed this means in
thirteen cases in my private practice, and in three in the
ISTew York State Hospital for Diseases of the Nervous Sys-
tem. Strychnia has been given at the same time, but un-
doubtedly the beneficial results are mainly to be attributed
to the ether.

In the paroxysmal forms of chorea, ether or chloroform
by inhalation is often necessary to cut short or prevent an
immediate seizure, but in other respects the treatment men-
tioned is entirely applicable.

In all cases hygienic measures are of the utmost impor-
tance. Exercise in the open air is indispensable ; the food
should be of the most nutritious character ; the bedroom
should be well ventilated ; bathing should be frequent ; the
bowels should be kept well regulated, and the child, if at
school, should be at once removed, and all study for the
time be interdicted. Ridicule or threats, so often indulged
in toward choreic children, generally do harm, but at the
same time they should be encouraged to use all reasonable
efi'ort to prevent a bad habit being formed. In the epi-
demic variety of the disorder, threats, and even strong re-
pressive measures, are, on the contrary, decidedly beneficial
in curing and arresting the further progress of the disease.

CHAPTEE YI.

HYSTERIA.

A LAEGE volume might be written on hysteria — and
many such have been published — and there would still be
points in its clinical history unconsidered. It is difficult,
therefore, in a general treatise like the present, to give a
full view of a disease which plays so important a part in
nervous pathology, and which is so varied in its manifesta-
tions. The most that I can hope to do is to lay down cer-
tain broad principles and features, and leave the recognition
of details to the intelligence and discrimination of those
who read this work.

Symptoms. — The phenomena of hysteria may be mani-
fested as regards the mind, sensibility, motility, and visceral
action, separately or in any possible combination. Thus it
is not uncommon to meet with cases in which the only evi-
dence of the disease is seen in abnormal mental action ;
others are characterized solely by derangements of sensibil-
ity, such as hypersesthesia or anaesthesia ; others by aberra-
tion of the faculty of motion, such as paralysis, spasms, con-
tractions. Again, all of these categories may be witnessed
in the same person, giving rise, among other phenomena, to
coma and convulsions ; and again, some one or more of tlie
viscera may be deranged in their functions, and thus the
appearance of organic disease be simulated.

As there is such a marked want of uniformity in the
character of hysteria as it affects different persons, I will

620

CEREBEO-SPINAL DISEASES.

not endeavor to present a typical case of the disorder, but
will consider separately the principal phenomena which
may have an hysterical origin. But, in setting out to
make the attempt, I am reminded of Dante's despair at the
thought of his inability to describe the horrors of the ninth
gulf :

" Chi poria mai pur con parole sciolte
Dicer del sangue, e delle piaghe appieno,
Ch'io ora vidi, per narrar pici volte ?

Ogni lingua per certo verria meno,
Per la nostra sermone, e per la mente,
C'hanno a tanto comprender poco seno."

The HysUriGol Diathesis. — Though it is very common
to hear the hysterical diathesis or temperament mentioned
by medical authors, I have never been able to recognize its
existence by any external traits. The fact that it has been
so very differently described by writers, from Hippocrates
and Galen, to our own day, is good evidence that it is not
readily detected.

Thus, Hippocrates and Galen recognized the existence
of the hysterical temperament, but each gave it different
characteristics. Louyer-Villermy ^ had very decided views
of its features, and he described it as follows :

" Every hysterical woman is stout, short, dark, plethoric,
full of life and of health. The complexion is brunette and
ruddy, the eyes black and sparkling, the mouth large, the
teeth white, the lips of a carnation red, the hair luxuriant
and of the color of jet, the sexual organs well developed,
and the spermatic liquid abundant."

Aside from his physiological error relative to the sper-
matic liquid, these are the characteristics of the women of
the south of Europe. If he had lived in the north, M'here
hysteria is fully as common, he would have found that his
description of the hysterical temperament would not have

' Quoted by Briquet, Trait6 Cliniaue et Therapeutique de I'Hysterie, Paris,
1859, p. 91,

HYSTERIA.

621

held good. Indeed, Sydenham, Whyte, Copland, and other
English authors, represent the hysterical predisposition with
almost the very opposite characteristics. As Briquet ' re-
marks, there is no hysterical constitution appreciable by the
study of external appearances. The disease takes women
as it finds them, blondes, brunettes, stout, thin, strong,
weak, ruddy, or pale, there is no choice. Some hysterical
women have delicate figures, and intelligent minds, but
there are others whose dull, stolid faces give evidence of
their stupidity ; and others, again, whose thin, fleshless, and
wan faces, tell us that the Greek type of female beauty is
not to be regarded as predisposing to the development of
hysteria.

While, therefore, admitting the existence of the hysteri-
cal diathesis, I know of no marks by which its presence can
be determined, other than the acts of the patient, which go
to make up the clinical history.

Mental Symptoms. — These are very various, but gener-
ally consist in emotional disturbance, an inability or indis-
position to exert the will, and in the existence of illusions,
hallucinations, or delusions. Attacks are often character-
ized by no other prominent symptoms than those connected
with mental action, and they may assume every possible
character. At times, the patient is depressed in spirits,
and sheds tears profusely ; a few minutes afterward, she
has forgotten her grief, and laughs immoderately, without
adequate cause. Sometimes she laughs and cries at the
same time.

Or, there may be a total insusceptibility to any emotion,
a listless insouciance.^ which contrasts strongly with her
natural disposition. Or, again, an emotion the. exact oppo-
site of the proper one is excited. This is quite a common
.form of manifestation. A mother, for instance, is informed
that her daughter has contracted an improper marriage,
and is immediately seized with immoderate laughter, and

1 Op. cit., p. 92.

622

CEREBRO-SPINAL DISEASES,

shows every expression of pleasure, when the rest of the
family are overwhelmed with grief and shame. Another
draws the chief prize in a lottery, and begins at once to cry
and wring her hands. A third, hearing that burglars have
entered the house and have stolen all her jewelry and
silver, sits stolidly in her chair, her hands folded in her lap,
and her whole expression indicating the most complete
indifference. During either of these conditions, she may
be entirely silent, or excessively voluble, or she may exhibit
other hysterical phenomena.

As regards the will, the manifestations of disorder are
sometimes very remarkable. That the patient is, for the
time being, unable to exert it, is evident, but, under the
influence of some strong exciting cause, she frequently
astonishes those about her by suddenly reacquiring her lost
volitional power.

A young lady came under my charge for what was sup-
posed to be a disease of the spinal cord. She had taken to
her bed suddenly, soon after striking her back rather gently
against the edge of a table, declaring that she could not walk.
On examination, I was convinced that there was no disease
whatever of the spine, other than that of a purely hysterical
character, and I so expressed myself to her. She, never-
theless, insisted upon it that her spine was seriously injured,
and she continued to keep her bed, lamenting daily her sad
fate at being compelled to pass so long a time shut out from
the enjoyments of life. There was no paralysis or even
simulation of it, for she moved her legs about freely enough
in the bed. But, one evening, her brother, who had long
been absent, returned home. She heard the bustle in the
house attendant upon his arrival, but all were too busy to
pay any attention to her in her chamber up-stairs. Sud-
denly exclaiming, " I can stand this no longer," she sprang
from her bed, rang for her maid, and, hurrying on her
clothes, proceeded down- stairs and entered the drawing-
room, to the great surprise of all the family.

HYSTERIA.

623

In another case, a lady closed her eyes, and declared that
she could not open them. She was brought to me as a case
of double ptosis. There was no spasm of the orbicularis pal-
pebrarum on either side, and I had no difficulty in opening
the eyes by gently raising the lids. The pupils were normal ;
there was no diplopia, and there were no evidences of such
cerebral lesions as are generally met with as causes of ptosis.
Moreover, she was subject to paroxysms of hysterical syn-
cope. Under the circumstances, I had no hesitation in
expressing my opinion to her friends that the case was one
of hysteria. I advised the use of the induced current to
the eyes, and she found this so disagreeable, not to say
painful, that two applications were sufficient to restore her
volitional power, so that she opened her eyes without diffi-
culty.

In my remarks on aphasia, I have cited a case (p. 166)
in which the power to speak suddenly returned under the
influence of excitement, and was as suddenly lost again, to
be gradually recovered.

Many cases of this loss of volition in hysteria have been
under my care, and most physicians have witnessed similar
instances.

Illusions are very common phenomena of hysteria, and
these may be connected with any or all of the senses. A
ball rolling over the floor is taken for a rat ; the sound of
rain falling on the roof is mistaken for the noise of burglars
in the next room ; the knives used at table all smell
" fishy ; " every thing tastes sour or bitter or sweet, as the
case may be, and a draught of cold air on the hand is sup-
posed to be the touch of a person or a spirit.

Hallucinations of various kinds are equally frequent.
Images are seen where there is nothing ; voices are heard
where there is absolute silence; odors are smelt where there
is nothing to smell ; and strange tastes are perceived when
the mouth is empty.

Thus one patient sees angels, another demons, another

624

CEREBRO-SPIlsAL DISEASES.

animals of various kinds. One hears voices whispering to
her, another musical sounds, and another noises like the
breaking of glass or dishes. Another is constantly sensible
of a smell as if something is burning, and another always
has a taste of turpentine in her mouth.

It is not often the case that these erroneous perceptions
impose on the intellect, but sometimes they do, and then
delusions are entertained, or these may, as in cases of abso-
lute insanity, be formed without the intervention of the
deranged perceptive faculties. They differ, however, from
the delusions of insanity, such as have been already de-
scribed, in the facts that they do not last long, and that
they rarely exercise any vei'y powerful influence over the
actions of the patient.

Besides these mental phenomena indicative of cerebral
disturbance, there are, sometimes, an extraordinary acute-
ness of understanding and readiness at reasoning and
speech quite beyond the natural powers of the patient. At
other times, on the contrary, the intellect is dulled, and the
conversational power reduced to a low point.

Sensibility. — This may be affected so as to result in the
production either of liyjpercesthesia or ancesthesia.

Hypersesthesia, caused by hysteria, is characterized by
the facts that it is never permanently fixed in one place,
that it is generally excessively acute, and that it is unac-
companied by evidences of serious disease of the nervous
centres or the nerves. A common seat is the skin, and its
favorite regions are the trunk, especially the skin over the
mammary glands, and that covering the labia majora. An-
other situation frequently affected is the skin of the face.

Cutaneous hypersesthesia may consist either of sponta-
neous pain or of tenderness to impressions made upon the
surface of the body. Muscular hyperaesthesia, or myalgia,
is likewise common. Dr. Inman* has investigated this
branch of the subject very carefully, and has ascertained

' On Myalgia : its Nature, Causes, and Treatment, etc. London, 1860.

HYSTERIA.

625

that the painful spots correspond to the origins and inser-
tions of the muscles.

Muscular pains due to hysteria are often mistaken for
pains of the viscera. Thus the headache which is so fre-
quent a phenomenon of the hysterical condition is very
seldom located within the cranium. It may be of very lim-
ited extent, constituting the form known as the clavus hys-
tericus, or may be of more extensive limits. Its ordinary
situations are the frontal regions, occupying, in this case,
the occipito-frontalis and corrugator supercilii muscles ; the
temporal regions, being then located in the temporal mus-
cles ; the vertex, being then seated in the tendon of the
occipito-frontalis muscle ; and the occipital region, in the oc-
cipito-frontalis, trapezius, spleuius and complexus. Briquet
states that, of three hundred and fifty-six hysterical patients
whom he questioned on the subject, three hundred were
constantly subject to headache. I have very rarely met
with a case of hysteria in which it was not constantly pres-
ent, and never one in which it was not a symptom at some
time or other.

Pains are often felt in the muscles of the chest, abdomen,
and back. This latter is a favorite situation, especially in
the region between the shoulders, and in the muscles on
each side of the vertebral column in the lumbar region.

Pains in the joints are common manifestations of hys-
teria, and they are often mistaken for serious organic dis-
ease. When, as is sometimes the case, they are accompa-
nied with contractions of the muscles, the liability to error
on the part of the practitioner is increased. Sir Benjamin
Brodie,' several years ago, pointed out the true nature of
certain aftections of the joints occurring in hysterical women,
and, since his time, others, among whom Barlow " and Skey '

' Illustrations of Certain Local Nervous Affections. London, 1837.
* A Treatise on Diseases of the Joints. London.

8 Hysteria, etc. Six Lectures delivered to the Students of St. Bartholo-
mew's Hospital, 1866. London, 1867.
40

626

CEREBRO-SPINAL DISEASES.

are to be mentioned, have called special attention to the sub-
ject The pain may be attended witli swelling, but there is
no accumulation of fluid in the cavity of the synovial mem-
brane. The knee is more frequently affected than any other
joint.

Neuralgia often has an hysterical origin, and may be in
the form of toothache, pleurodynia, sciatica, or pain in the
course of any other nerve. The viscera are likewise fre-
quently hyperaesthetic ; the stomach, bowels, the kidneys,
bladder, uterus, and ovaries, are the organs most frequently
affected.

The organs of the special senses rarely escape having
their sensibility exalted, and, consequently, there are in-
creased power of vision, morbid acnteness of hearing, and
an abnormal sensitiveness of the smell and taste. Sometimes
with these hyperaesthetic conditions there is pain.

Ancesthesia. — Though not so common as hyperaesthesia,
anaesthesia is frequently a manifestation of hysteria. Its
most common seat is in the skin. In the days of witch-
craft, many an hysterical woman, with anaesthetic spots on
her skin, went to the gallows or the stake on suspicion of
being leagued with the devil. The belief was that, wher-
ever the hand of the arch-fiend or his assistants touched the
skin, the spot at once lost its sensibility.

Two patients are now under my charge in whom there
is hemi-anaesthesia, paroxysmal in its character. When it
is at its height, no irritation applied to the skin is felt, not
even the wire brush of a powerful induction-coil. In
neither case are the attacks preceded or accompanied by
numbness.

Sometimes the location is very limited, and the loss of
sensibility may be partial or complete. In the former case,
there is numbness, and the full extent can only be exactly
ascertained by the aesthesiometer.

The mucous membranes may become anaesthetic. The
one most frequently affected is that which lines the genital

HYSTERIA.

627

canal. In such a case, the sexual passion is entirely extin-
guished, coition is unattended witli pleasure, and may even
excite disgust.

The organs of the special senses may be the seat of an-
aesthesia, and thus blindness, deafness, loss of the senses of
smell and of taste, may be caused, more or less complete in
character, in different cases.

Anaesthesia of the muscles is occasionally met with, and
has, at times, been the occasion of much discussion in medi-
cal and theological circles. Many of the phenomena ob-
served in the Jansenist convulsionnaires were the result of
muscular anaesthesia. In an essay * recently published, I
have called attention to the symptoms, and have adduced
several cases from the records of my own experience. The
extent of the anaesthesia is sometimes remarkable. In some
of the cases that have been under my care, the most power-
ful induced currents which it was safe to use failed to cause
pain in the muscles to which they were applied.

Alterations of Motility. — These may be evidenced in the
way of paralysis or of clonic or tonic spasm.

Hysterical paralysis has long been known, and is quite a
common manifestation of the affection. It may appear in
the character of hemiplegia, paraplegia, or of much more
restricted extent. I have a case, now under care, in which
it is limited to the index-finger, and I have had several in
which a single muscle of the eyeball, or in which the
levator palpebrae superioris, was alone affected.

Hysterical aphonia is due to paralysis of one or more
muscles of the larynx. Like the loss of power in other
muscles from a similar cause, it often comes on very sudden-
ly, and as suddenly disappears.

Paraplegia, hysterical in its character, may be partial or
complete as regards a muscle, group of muscles, or a limb.
"When incomplete, the patient, if it involves the lower
extremities, drags her limbs sluggishly along, or shufSes
' The Physics and Physiology of Spiritualism. New York, 1871.

628

CEREBRO-SPINAL DISEASES.

her foot over the floor, using a cane or crutches, or holding
on to articles of furniture that may be in the room. There
is nothing about the gait like that of locomotor ataxia or,
in fact, of any other of the diseases of the cord already
considered ; and careful observation will generally reveal
the fact that, during one interview and examination, the
patient walks very unequally, according to the state of her
mind at the time, or the influences which act upon her.

Spasms may be either tonic or clonic, and may afiect
any muscle of the body. In the pharynx, tonic spasm causes
the sensation to which the term globus hystericus is applied,
and which gives rise to the sensation of a ball in the throat.
In the oesophagus, spasm may continue for a long time, and
may thus simulate stricture. It may also be seated in the
stomach, intestines, or bladder.

In the limbs spasm of the tonic character causes con-
traction, and thus, especially when combined with paralysis,
may give the appearance of organic lesion. I have fre-
quently known hysterical contractions to last several months
at a time, and have had many cases of the kind under my
charge in which the actual cautery had been applied to the
back for supposed inflammation of the cord.

Clonic spasms simulate chorea. They are especially
common among the women who attend spiritualistic gath-
erings, and indeed I have seen several cases at such places
among the weak-minded men who believe in the nonsense
called spiritualism.

The functional actions of the viscera are exceedingly
liable to derangement in hysteria. Any organ of the body
may be affected, but the stomach appears to be the favorite
one. There may be obstinate vomiting, or persistent flatu-
lence, or acidity, or indigestion in some other form ; or
the bowels may be the seat, giving rise to intestinal indiges-
tion, diarrhoea, or obstinate costiveness ; or the kidneys may
be involved, and there may be an enormous secretion of
pale, limpid urine, or the quantity may be reduced to a

HYSTERIA.

629

minimum ; or the uterus or the ovaries may be the seat.
ISTot infrequently organic disease of the heart is simulated,
there being palpitation and general irregular action of this
organ.

Besides these several manifestations of hysteria, there
are paroxysms of the disease, characterized by emotional
disturbance, spasm, convulsions, partial loss of conscious-
ness, and sometimes coma. All these phenomena may be
manifested during an attack, or a seizure may consist of any
one or more of them. The convulsions sometimes bear a
resemblance to epilepsy, sometimes to tetanus, sometimes to
hydrophobia, sometimes to catalepsy, sometimes to chorea.
But, though simulating these diseases, the hysterical parox-
ysm can be readily distinguished from either of them, mainly
by the facts of its lack of consistency, the absence of the
constitutional disturbance which attends the others, and by
the presence of emotional excitement, and the consequent
irrational laughing or crying.

Mania may be simulated, but the false can scarcely be
mistaken for the real disease by any practitioner with his
wits about him.

Causes. — Of the predisposing causes, sex stands first.
During the last six years three hundred and thirty-two
cases of hysterical disease have been under my charge or
been seen by me in consultation. Of these, three hundred
and twenty-nine were females. Of the three males, one was
a young gentleman, the son of a distinguished citizen of
Virginia, in whom the affection was induced by excessive
study. One was a lawyer in this city, the disease in him
simulating epilepsy ; and the third was a shop-keeper from
New Jersey, who had tetanoid paroxysms attended with fits
of sobbing, crying, and laughing, and in whom it was ex-
cited by masturbation.

But, while there is this great predominance of females
as the subjects of hysteria, I do not believe that the fact is
due to any particular influence of the uterus or other gen-

630

CEREBRO-SPINAL DISEASES.

erative organs. It is probably the result of the delicacy of
organization, and the greater development of the emotional
system, acted upon by the exciting causes to be presently
mentioned.

Age is another predisposing cause. The period of life
at which hysteria is most common is that extending from
sixteen to twenty-five. After the latter age there is a grad-
ual decline until the age is reached at which the menstrual
function begins to become irregular, and then the number
of cases increases.

The civil condition, as regards marriage or celibacy, is
to be taken into consideration among the predisposing
causes. Undoubtedly the disease is much more frequent
among the single than the married, but it is by no means
confined to them. In my opinion the increased proclivity
of single women to hysteria is not to be attributed to un-
gratified sexual desires, or even to the non-fulfilment of the
functions of the generative organs, but rather to that lack
of aims in life, and the consequent reflection of the thoughts
and emotions upon self, which are so inseparably connected
with the present condition of single women. Certainly
those celibates who have made for themselves objects in
existence are no more subject to hysteria, in my experience,
than married women. "Want of occupation is one of the
powerful predisposing causes of hysteria, and it is to a great
extent through the direct influence of this factor acting
upon a more impressionable organization that, in my opin-
ion, hysteria is more common in women than in men. In
those savage and semi-savage countries where women work,
hysteria is unheard of. It used to be almost unknown
among the negro women in the South, but since their
emancipation, if my inquiries have ascertained the truth,
it is becoming quite common among them.

Hereditary influence is undoubtedly an important pre-
disposing cause of hysteria. My own statistics are not
complete on this point, but of the two hundred and nine

HYSTERIA.

631"

instances in which I have made the inquiry, one hundred
and thirty-one had either hysterical mothers, aunts, or grand-
mothers, and many of the others had relatives affected with
other nervous diseases. Briquet speaks very emphatically
of the decided influence of hereditary tendency as deduced
from his inquiries.

The luxurious habits of life attendant upon refinement
and education conduce to the development of hysteria. At-
tendance at theatres and operas, the cultivation of music,
the reading of poetry and novels, the study of art, and any
other influence capable of developing the emotional system
at the expense of the purely physical or intellectual, favor
the growth of hysterical tendencies.

Of exciting causes, sudden emotional disturbance ranks
first. Anxiety, grief, disappointment, the intense desire of
self-gratification, a fit of ill-temper, with other similar fac-
tors, often induce paroxysms of the disease. Mental or
physical fatigue, menstrual derangement, or uterine or ova-
rian difficulties, may also act as exciting causes.

But probably, above all these, is the contagion set in
action by the contact with an hysterical person. I have seen
a whole hospital ward of women thrown into paroxysms of
hysteria by one patient sufi'ering from an attack.

Diagnosis. — To detail the diagnostic marks which distin-
guish hysteria from other diseases would require more space
than is proper in a work like the present, and would, more-
over, be rather a work of supererogation. The physician
has simply to recollect that all hysterical afiections have a
family resemblance, and that, although almost every known
disease may be simulated, yet that the counterfeit is never
a good one. Attention to the symptoms of the several dis-*
eases already and to be described, with a careful observa-
tion of the case, and due inquiry into the antecedents of the
patient, will prevent a mistake being made.

He must also recollect tliat the hysterical patient always
tries to impress others with the belief that she is very ill.

632

CEREBRO-SPINAL DISEASES.

She craves sympathy, and feeds on it with the effect of
nourishing her disease. If she can deceive her medical
attendant by appealing to his kindly emotions, she will do
it, but failing in this she will try her power over his fears,
and will leave no stone unturned to deceive him. Careful
watching, with thorough skepticism, will either result in
her detection, or in her defeat from sheer weariness.

Prog-nosis. — As regards the prospect of recovery from
any particular manifestation of hysteria, or from a parox-
ysm of any kind, the prognosis is favorable, provided proper
treatment be employed, but, as regards the liability to
further attacks, much depends on the circumstances which
surround the patient and the time during which she has
been subject to the affection. If she can be submitted
to proper treatment, without the interference of herself or
her friends, the prospect of recovery, even in bad cases, is
good; but if she is to be allowed to do as she pleases, or
if injudicious friends are constantly lavishing the sympathy
and mistaken kindness which keep her disease alive, there
is not much use in medicine or hygiene, and, as Reynolds
says, the " case is hopeless, and might as well be left
alone."

Morbid Anatomy and Pathology. — Hysteria contributes ab-
solutely nothing to the science of morbid anatomy. The
brain, the spinal cord, the sympathetic nerve, give no evi-
dence of its former presence. It is true, hysteria very
rarely causes death, but hysterical patients have died of
intercurrent affections, and post-mortem examinations have
been made, and nothing which could reasonably be regard-
ed as the essential cause of the disease has been found.
Several of the older writers imagined that they had discov-
ered the lesion in the genital organs, in the stomach and
intestines, in the brain, and even in the spleen ; but modem
research teaches us differently. At present, then, we are in
total ignorance of the character of the lesion. From the
symptoms, which are so obviously indicative of disordered

HYSTERIA.

633

brain and spinal cord, I have felt myself justified in classing
it provisionally at least among the cerebro-spinal diseases.

The pathology or morbid physiology of hysteria is be-
ginning to be better understood as our knowledge of the
cerebral and spinal actions becomes more complete. Look-
ing at the brain as a complex organ evolving a complex
force — the mind— we can understand the possibility of cer-
tain parts of it becoming disordered, as regards excess, dimi-
nution, or quality, in the results of their actions. We have
seen, under the head of insanity, that the mind is made up
of certain sub-forces — the perception, the intellect, the emo-
tions, and the will — and that these, when disordered, consti-
tute varieties of insanity, which are easily recognized.

Hysteria essentially consists in the predominance of the
emotions over the intellect, and especially over the will,
and this exaltation may be so intense as to interfere with
the sensibility of various parts of the body, or to derange
the contractility of muscles.

At the same time, in the paroxysms of the disease, the
reflex and automatic functions of the spinal cord are in-
volved to a great extent.

We daily witness examples of the influence of emotions
on sensibility and motility. Fear renders the sensibility
more acute and produces trembling, which is simply clonic
spasm ; grief causes tonic contractions of the muscles ; sur-
prise, terror, or horror, paralyzes them ; joy or anger de-
stroys sensibility to pain, and so on.

At the same time that there is this exaltation of emo-
tional power in hysteria, the power of the will is not only
relatively but is absolutely diminished. The two factors,
acting together steadily and persistently, induce many of
the manifestations of hysteria. The disease is, therefore, a
partial insanity — an insanity, however, in which the patient
does not entirely lose the power of control, and which is
capable of being overcome by the voluntary effort of the
patient, provided a suflScient stimulus to normal volition

634

CEREBRO-SPINAL DISEASES.

be brought to bear. It thus happens that, through the
influence of such stimulus, every symptom of hysteria dis-
appears as if by magic.

The spinal cord is often secondarily affected, and it is
likewise frequently primarily involved. The gray or the
white substance, the posterior or the antero-lateral columns
may be implicated, the symptoms varying accordingly.
Through the spinal cord, in its abnormal condition, we have
the convulsions of various kinds, the spasms, contractions,
and the paraplegic phenomena connected with motion and
sensation.

As to the influence of the vaso-motor system, though I
admit its existence, I am convinced that it it is simply a
link in the chain, and is secondary to the emotional disturb-
ance already mentioned.

Treatment. — No cases are so well calculated to test the
patience and tact of the physician as those of hysteria.
For he has an afiection to deal with which not only requires
proper medical treatment, but in which he must often exert
the highest mental qualities, in order to cure the disease.
A great deal, therefore, depends on the knowledge of human
nature and the force of character of the physician ; and it is
doubtless owing to this fact that some physicians, with all
their medical knowledge, fail in curing hysterical aflfections,
while others, with no superior science, succeed at once.

The first thing to be done is to gain the confidence and,
what is of still greater importance, the respect of the patient.
Having done this, any treatment, moral or medical, calcu-
lated to relieve her, will be much more apt to produce the
desired effect.

During the period between the paroxysms, the treatment
must be directed mainly against symptoms. If the pa-
tient can be made to believe that her case is thoroughly
understood, that she is not suspected of shamming, and that
with her assistance the hypersesthesia, or anaesthesia, or
paralysis, will be removed, the effect which is desired will

HYSTERIA.

635

probably be produced. For putting an hysterical patient
into a proper frame of mind, I know of nothing equal to
the bromides, of either potassium or sodium, given in large
doses, repeated three or four times a day, till the full effect
is obtained. This, of itself, will generally relieve hyperaes-
thesia wherever it may be seated, and the influence over
the mental phenomena of the disease is usually very decid-
edly shown.

If anaesthesia be the prominent condition, electricity is
to be used, and it is almost a specific. I have never seen a
case of hysterical ansesthesia resist it. A few days ago, I
was consulted by a young lady who was entirely anaesthetic
over the whole of the surface of one side of the body, and
who had suflFered for several weeks. Three applications of
the induced current through the wire brush, which was
passed, at each seance, over the whole anaesthetic region,
entirely cured her.

For hysterical paralysis, strychnia and phosphorus are
the best internal remedies. They may be taken together in
the form recommended on page 58, and rarely fail to pro-
duce a cure. Their effect is, however, greatly increased by
the use of electricity, both of the primary and induced
forms — the first being applied to the spine, and the latter
to the paralyzed muscles.

In cases of spasm, I prefer the bromides, internally, and
the primary galvanic current, applied to the contracted
muscles.

Yisceral derangements are best treated by strychnia and
phosphorus, as recommended for paralysis. Counter-irrita-
tion, in the form of blisters, is almost always of service.
For gastric difficulties, the subcarbonate of bismuth, in
doses of fifteen or twenty grains, after each meal, will gen-
erally prove of service. In a very obstinate case of hysteri-
cal vomiting, recently under my charge, every thing failed
but hydrocyanic acid.

Hysterical paroxysms are best treated with ether or chlo-

636

CEREBRO-SPINAL DISEASES.

reform, administered by inhalation. Recently I have re-
peatedly used the hydrate of chloral, but it has not in my
hands been as speedy or as effectual in its action as either of
the other agents. I give them to the extent of producing
complete insensibility, and repeat them again and again, if
there are any evidences of a return of the seizure. Whether
in the purely emotional paroxysms or those characterized by
muscular spasms of various kinds, or any possible combina-
tion, nothing is equal, according to my experience, to ether
or chloroform by inhalation. I have tried every other
known means, from cold water, dashed in the face, to moral
suasion, and none of them are comparable to ether or chlo-
roform.

But, for the dissipation of the hysterical tendency, long-
continued treatment is necessary. Medicines which are
ordinarily regarded as antispasmodics, such as valerian,
assafoetida, musk, and the like, I have never seen produce
any benefit in any form of hysteria, and, for the purpose of
causing any radical change in the organism, they are worse
« than useless. As medicines for this object, I know of
nothing superior to phosphorus, in some one of its forms,
and strychnia. They should be taken for months in small
doses, and should be supported by all hygienic measures cal-
culated to improve the tone of the system. Travel is of ines-
timable advantage, and, above all, association with persons
of both sexes, whose intellects control their emotions, and
who are endowed with sound common-sense and that tact
and knowledge of human nature which, for the purposes of
every-day life, are of more value than many other qualities
often ranked above them.

It is, perhaps, scarcely necessary to state that the society
of other hysterical persons must be rigidly eschewed, and
that even the casual meeting with such individuals is dan-
gerous.

CHAPTER VII.

MULTIPLE CERE3R0-SPINAL SCLEROSIS.

We have already considered the subject of sclerosis as
it affects the brain and spinal cord separately. "We have
still to treat of it as existing in these nervous centres simul-
taneously. Although recognized, over thirty-five years ago,
by Cruveilhier and Carswell, it is only recently, mainly
through the observations of Charcot and Yulpian, that
attention has been again directed to sclerosis of the cerebro-
spinal variety, a form which differs from those already de-
scribed in this treatise, both in its extent and in the symp-
toms by which it is characterized.

Symptoms. — The initial symptoms vary according as the
morbid process begins in the brain or spinal cord. In the
former case, the first prominent manifestation of disease
may be an epileptic fit. In other cases, there are headache,
vertigo, ocular troubles, such as ptosis, diplopia, or ambly-
opia, failure of the hearing, and, very often, defective articu-
lation. The mind does not participate to any considerable
extent, unless the hemispheres be involved in the lesion.

Or, there may be hemiplegia as a consequence of cere-
bral congestion, and even mania, from a like cause. These
attacks are sometimes frequent, and usually leave more or
less mental weakness after them.

Tremor is often first seen in tlie tongue, more frequently
in the eyeball, of one or both sides, which oscillates when
the patient is told to turn it inward or outward, but which
is steady when he looks directly to the front. Tliis tremor

638

CEREBRO-SPINAL DISEASES.

is called nystagmus, and is, as we have already seen, met
with in other diseases of the nervous system.

Tremor is indicative of loss of power, and it gradually
becomes more strongly marked and extends to other mus-
cles of the body as other parts of the cerebro-spinal system
become involved. It is never, however, a constant phenom-
enon in any form of sclerosis affecting the spinal cord alone.
Its presence is peculiar either to cerebral disease or to
lesions occurring at the same time in the brain and spinal
cord.

After a time, which is subject to great variation in dif-
ferent cases, the loss of power extends to the limbs, and
this feature is often accompanied with aberrations of sensi-
bility. If, as is generally the case, the membranes of the
cord are congested or inflamed, there are spasmodic jerk-
ings or twitchings of the limbs, but in some cases these are
never observed. In the case of a gentleman from South
Carolina, who consulted me at the instance of my friend
Dr. Darby, of that State, and who was obviously affected
with multiple cerebro-spinal sclerosis, there had never been
the slightest involuntary movement, independent of the
peculiar form of tremor in the limbs which constitutes so
prominent a feature of the disease.

The lower extremities are generally very much more
paralyzed than the upper, and, when they become involved,
festination often makes its appearance. The gait of the
patient, thus, becomes similar to that of a person in whom
the lesion is limited to the brain.

If the sclerosis begins in the brain before attacking the
spinal cord, tremor precedes the paralysis — the affection
being then entirely cerebral in character; but, when, as is
generally the case, the lesion appears primarily in the spinal
cord, paralysis is noticed before the tremor. In fact, there
is never, as previously insisted on in my remarks on multiple
cerebral sclerosis, any tremor, unless the superior ganglia of
the cerebro-spinal system are involved. The fact that it is

MULTIPLE CEREBRO-SPINAL SCLEROSIS. 639

only shown wlien a voluntary movement is made also assists
us to distinguish it from the tremor of multiple cerebral
sclerosis, as well as from that of paralysis agitans. In the
cerebro-spinal form of the disease, therefore, the patient re-
mains without tremor so long as he is quiescent. But, if he
attempts to cross one leg over the other, or to carry a glass
of water to his lips, the extremity executing the movement
is at once seized with tremor, and the act is performed with
great difficulty.

The ability to place the fingers on any part of the body,
unassisted by the eyesight, is impaired, as in the cerebral
form of the disease, and in sclerosis affecting the posterior
columns of the spinal cord.

As the disease advances, the paralysis becomes more
strongly marked ; the limbs are permanently contracted ;
the bladder loses its expulsive force ; its sphincter no longer
completely closes the orifice ; the bowels become obstinately
constipated, and there is a strong tendency developed to the
formation of bed-sores. The head-symptoms likewise in-
crease in intensity, but the mind remains clear to the last
in the great majority of cases. Indeed, my observation of
many cases has convinced me that in the cerebro-spinal
form of sclerosis the hemispheres are not often involved,
even when the disease has lasted several years.

The difficulties of articulation notably increase, and the
muscles of deglutition likewise become involved. In con-
sequence, the saliva is not swallowed as often as it should
be, and it therefore dribbles from the mouth. Mastication
is difficult, and the facial muscles gradually become in-
volved. The countenance of the patient at this period is
not unlike that of a person suffering from glosso-labio-laryn-
geal paralysis, as in fact might be expected, the same nerves
and muscles being involved. Finally, the patient dies from
exhaustion, or from some intercurrent disease.

Few diseases are so irregular and ununiform in their
phenomena as the cerebro-spinal form of sclerosis. This

640

CEREBRO-SPINAL DISEASES.

is due to the fact that the organs liable to be the seat of
the disease are numerous and of varied functions. The es-
sential features of the affection are tremor occurring gener-
ally after paralysis, and only manifested during the perform-
ance of voluntary movements. It is not always necessary,
however, that the movements should be of the partially-
paralyzed limbs, for I have seen cases in which tremor was
excited in a paretic leg by the act of executing voluntary
movements with a sound hand.

The following histories will contribute to a fuller under-
standing of the subject :

Cruveilhier ' reports the case of a cook, aged thirty-seven,
who six years before coming under observation noticed that
he was losing power in the left leg, so that he nearly fell in
the street. Three months subsequently the right leg be-
came similarly affected, and then the superior extremities
followed. They were tremulous and weak, but the patient
was still able to use them to some extent. The sensibility
remained intact, and the reflex faculty of the cord was un-
impaired. In other respects the patient was condemned
to immobility. There were no spasmodic retractions of the
limbs, and no painful contractions. The articulation was
imperfect, but the intelligence was unaffected. There ap-
pear to have been no marked head-symptoms in this case.
" Point de cephalalgie jamais de cephalalgie, le malade en-
tendait a merveille." After death there was found gray
degeneration of the spinal cord, of the medulla oblongata,
of the pons Varolii, of the right cerebral peduncle, of the
right optic thalamus, of the corpora callosa, and of the for-
nix. The hemispheres were not involved.

Two other cases, similar in general character to the fore-
going, are given, in neither of which were the hemispheres
involved.

Another case, that of Josephine Pajet, is cited by Cru-

' Anatomie pathologique du corps humain, Paris, 1835, 1842, t. ii., liv.
xxxii., Fig. 4, PI. II.

MULTIPLE CEREBRO-SPINAL SCLEROSIS.

veilhier.* In this there was almost complete insensibility
of the inferior extremities, though the patient was able to
move the toes, the feet, and the legs. There were no
cramps and no contractions. There was also diminished
sensibility of the superior extremities. All the limbs were
weak, and the arms were affected with tremor. The patient
could walk and sew when first seen. The right hand was
stronger than the left. There was a sensation of a tight
band around the abdomen. After death there was gray de-
generation of the cord, and of the pons Yarolii.

In none of these cases were there spasmodic jerkings or
tonic contractions of the limbs. Two cases have been re-
ported by Friedreich." In one of these a man, aged twenty-
one, was the subject. Among the first symptoms were men-
tal excitement, vertigo, pain in the head, and weakness of
the lower extremities. The gait was unsteady, and there
was tremor upon any emotional excitement, or on the at-
tempt to execute movements. This affected the upper and
lower extremities, the head and the eyeballs. After death,
patches of sclerosed tissue were found on the tubercula
mammillaria, the cerebral peduncles, the pons Yarolii, and
the medulla oblongata.

The other case was that of a woman, aged twenty, who
was attacked, when seventeen years of age, with weakness
of the rio;ht leg;. Soon afterward the left became affected,
and subsequently the arms. These latter were rendered
tremulous at every attempt to move them. The speech was
implicated, and there was nystagmus. The mind was weak-
ened, and the sensibility was impaired.

In the first of these cases the disease appears to have
begun in the brain ; in the second, in the spinal cord.

Yulpian,' under a title which goes to show how even the

' Op. cit., liv. xxxviii., Fig. 1, PI. V. ^ Deutsche Klinik, No. 14, 1856.

2 Note sur la Sclerose en Plaques de la Moelle epiniere. L'Union Medicale,
No. 70, Juin 14, 1866, p. 507. Like other writers, Vulpian, in this paper,
brings together cases which have no affinity except as regards the general char-
acter of the lesion.
41

642

CEEEBRO-SPINAL DISEASES.

best authorities have confused the whole subject of sclerosis,
describes an interesting case communicated by Charcot. In
this instance a woman aged forty-three, of nervous tempera-
ment, had been subject to frequent attacks of facial neural-
gia, and had often suffered from vague pains without deter-
minate seat. In 1856 she suffered from attacks of vertigo,
which, from being rare at first, subsequently came on five
or six times a day. Sometimes she fell, but never lost con-
sciousness, or had any convulsive movement.

Shortly afterward, during the night, she was seized with
vomiting, cramps in her limbs, and a numbness of the right
side. In the morning she was hemiplegic. Fifteen days
afterward motion reappeared in the arm, but the leg re-
mained paralyzed. In 1859 she had another attack of hemi-
plegia, and this time was deprived of speech for fifteen days.
After this seizure, there were contractions of the flexors of
• the fingers, and of the forearm of the right side. In 1861
she had a third attack.

In 1862 (January 1st) she came under M. Charcot's care.

The intellectual faculties were not involved. The right
superior extremity was almost entirely paralyzed, and was
in a state of rigidity and contraction. The lower extremities
were permanently extended, and could not be flexed but by
great effort. Sensibility was perfect throughout, and reflex
movements could still be excited. She died February 9th.

On post-mortem examination, patches of sclerosed tissue
were found in the right middle cerebral peduncle, the pons
Varolii, the medulla oblongata, and the cervical region of
the spinal cord. The hemispheres were perfectly healthy.

In this case, it is probable that the contractions were
mainly due to secondary degeneration of the cord, a condi-
tion which, as we have seen, is analogous to sclerosis. It
will be observed that there were no tremors, either with or
without voluntary motions.

Another important case has been reported by M. Ma-
gnan : '

' Memoires de la Society de Biologic, Paris, 1869.

MULTIPLE CEREBRO-SPINAL SCLEROSIS.

A woman, aged thirty-four, came under observation in
July, 1869. In 1848, when thirteen years of age, she
had an attack of typhoid fever, from which she lost her
sight. The first symptom of her disease occurred in 1867,
and consisted of trembling of the hands and arms whenever
she endeavored to execute any difficult movement. Before
long, the tremor involved the lower extremities ; but there
was no paralysis till about eight months previous to her ad-
mission to the hospital. At this time, every effort at motion
caused tremor. The hands, arms, legs, eyeballs, and even
the muscles of the trunk were involved. The articulation
was defective, and there were various painful sensations in
different parts of the body. Ophthalmoscopic examination
showed atrophy of the optic disks and nerves.

The diagnosis in this case was multiple cerebro-spinal
sclerosis — an opinion which I do not think is warranted by
the facts. The lesion was probably entirely confined to the
brain. The main reason which leads me to entertain this
view is, that the tremor appeared before the paralysis. I
cite the case for the purpose of showing how little accord
there is among authors relative to the association of symp-
toms with lesions in the several forms of sclerosis.

Eleven cases of the cerebro-spinal form of sclerosis have
been under my care ; and, though I have not had the oppor-
tunity of verifying my diagnosis in a single instance, I
think the symptoms have been of such a character as to
indicate the existence of the lesion so graphically described
by Charcot, Friedreich, and Bourneville and Guerard.^
The fact, that several of the histories were written out
before Charcot's investigations gave me a clew to their real
import, will tend, I think, to increase their value.

Mr. M., a gentleman fifty-three years of age, consulted
me April 8, 1865, at the instance of my friend Prof. For-
dyce Barker, M. D., for partial paralysis with tremor, mainly

' De la Sclerose en Plaques disseminees. Nouvelle Etude sur quelques
Points de la Sclerose en Plaques disseminees. Bourneville, Paris, 1869.

CEREBRO-SPINAL DISEASES.

affecting the riglit arm and leg. Two years previously he
had suffered from vertigo and headache, which were followed
by a slight attack of hemiplegia of the right side, unattend-
ed by loss of consciousness. He gradually recovered from
this, but, about six months before he came under my obser-
vation, he noticed that his right leg began to drag, and,
soon afterward, that the arm of the same side became weak.
About the same time he had headache, vertigo, and weak-
ness of sight. A short time subsequently — about a month
as well as he could recollect — the arm was seized with tre-
mor while attempting to carry a glass of wine to his lips.
The agitation continued to grow more violent on any vol-
untary movement of the arm, and gradually his speech be-
came involved.

When I saw him he was still suffering from occasional
attacks of vertigo and headache ; the lips were agitated
whenever he attempted to move them, the tongue was
tremulous, and his speech was consequently halting and
jerking. There was also nystagmus, a symptom which he
had not noticed.

The right arm was unaffected with tremor so long as he
allowed it to rest on his knee or to hang by his side ; but, in
the act of moving it, the whole extremity was agitated by a
series of short, vibratory motions, consisting of flexions and
extensions, which continued so long as he persevered in the
movement, or kept the arm in any position requiring mus-
cular exertion. The right leg was weak, and dragged so
that he struck his foot against any slight obstruction.
There was a little tremor in it when he attempted to cross
it over the other as he sat in a chair.

I treated him solely with the primary galvanic current,
which I passed through the brain and spinal cord — the first
time such an operation was ever performed in this country
for the treatment of disease. My diagnosis was incipient
softening of the ganglia at the base of the brain and of the
upper portion of the spinal cord. My opinion was, that the

MULTIPLE CEREBRO-SPINAL SCLEROSIS.

hemispheres were not involved, as there were no symptoms
indicating mental weakness or disturbance.

I made an application of about fifteen minutes' duration
every day. He gradually but rapidly improved, and to
such an extent that on the 19th of April he wrote to me as
follows :

" Yesterday must be marked with a white stone as the
best day yet. Foot active, hand and arm steady, and spirits
good. If we can manage to fix these good effects, cure is
certain.

" I hope the magic pile will be ready to repeat its good
work on Saturday next."

He continued to improve for several weeks, then gradu-
ally went back to his former condition, and from that rapid-
ly grew worse. The paralysis invaded the other side, then
tremor followed, the speech became much more difficult,
and he died in the country two years subsequently.

Miss H., of Connecticut, aged thirty-five, consulted me
January 20, 1870, for paralysis and tremor. About two
years previously, she had noticed a weakness of the right
arm, which had been preceded by occasional attacks of not
very severe headache and vertigo. The arm gradually be-
came weaker, and in the course of a few months began to
shake whenever she attempted to use it. Before the year
had expired, the right leg began to drag a little, and lost a
good deal of its natural strength. Her speech also became
difficult, not from any failure to remember words, but from
tremor of the tongue and weakness, with a little rigidity of
the lips.

When I saw her, the articulation was halting and syl-
labic; there was nystagmus in both eyes; the right arm
was very weak ; she could only move the index of my
dynamometer four degrees, equivalent to a pressure of two
pounds and a half, while with the left hand she could move
it twenty-eight degrees. Every attempt to move the arm
caused trembling of the whole extremity. So long as she

646

CEREBRO-SPINAL DISEASES.

refrained from any exertion of voluntary power, it remained
free from agitation. She could not write, owing to the tre-
mor which the effort to do so excited. There was slight
tremor in the leg, when she slowly raised the foot from the
ground.

The mind was perfectly intact, and she was entirely free
from any emotional weakness.

In this lady's case I diagnosticated multiple cerebro-
spinal sclerosis — the " sclerose en plaques disseminees" of
Charcot.

I treated her with the chloride of barium and the pri-
mary galvanic current. By the following autumn she had
improved so much that she could walk several miles without
fatigue, lifted her foot clear of the ground, could move the
index of the dynamometer to thirty degrees, was free from
tremor, except when she attempted to write, and then it
was only manifested to a slight extent. I now ceased using
the galvanism, but continued the chloride of barium. On
the 28th of January, 1871, she paid me a visit. She was
then walking well, but there was still a very slight tremor
when she attempted to execute delicate or difficult move-
ments with the right arm. I directed the continuance of
the barium.

Mr. H., of South Carolina, a highly-educated and intel-
ligent gentleman, consulted me, September 12, 1870, for
paralysis and tremor. As he entered my consulting-room,
the tendency to festination was exceedingly well marked.
On examination, I found his mind perfectly clear. There
were nystagmus and syllabic articulation. On moving the
left arm or left or right leg, the limb became tremulous.
There had never been any head-symptoms.

On the 19th, at my request, he wrote a short account of
his disease, which I here transcribe :

" I was never robust in health, but, on the other hand, I
have never had, since childhood, a serious spell of sickness.
My manner of life has been sedentary — that of a student.

MULTIPLE CEREBRO-SPINAL SCLEROSIS. 647

I was always careful not to overtask myself until I became
engaged, in the year 1864, in a mathematical research. 1
was for a considerable length of time very much absorbed
in this work, and allowed it to encroach seriously upon my
hours of recreation and sleep.

"In the fall of 1865, after having accomplished the
above work, I observed a slight lameness in my left foot — a
tendency to strike the toe against the inequalities of the
ground — an inability to raise quickly enough the front part
of the foot.

" After my return home, summer of 1866, from Europe,
where I had spent five or six years, the lameness in my foot
increased rapidly, and in the winter of 1866-'67 a lameness
in my left hand was very perceptible — an inability to move
the fingers quickly, and a tremor, particularly of the thumb,
when I attempted to do so.

" The above symptoms have gradually grown worse, and
within the last year the right leg has become involved, to
the extent that it begins to shake when I stand upon it, and
it shakes even while sitting, when I am under excitement,
or when I execute difficult voluntary motions with my
hands.

" The disease seems to make greater progress in hot
weather. I have at no time suffered pain, my appetite and
digestion are good, and I generally sleep well."

This gentleman improved greatly through the use of the
primary galvanic current, chloride of barium, and tincture
of hyoscyamus, during the two weeks that he remained in
New York under my care. On his return to South Caro-
lina he took a primary-cell battery with him.

On the 11th of January, 1871, he wrote to me as fol-
lows :

" Sometimes I thought I was improving slowly, or at
any rate not losing ground, and then again, for several days
together, I would feel confident tliat I was falling back.
But now I think I can certainly say I am growing worse.

648

CEREBRO-SPINAL DISEASES.

All my symptoms have been worse — lamer, more nervous,
and the disease more general in its effects. My right hand,
which has heretofore been comparatively unaffected, is now
seriously implicated, and yet I still manage to write after a
fashion. I find it very difticult to dress myself, and I must
make several attempts before I can get up from a sitting or
a lying posture.

" What could have caused the improvement that took
place while I was under your immediate treatment?"

In this case I diagnosticated multiple cerebro- spinal
sclerosis, and I think those acquainted with the disease will
agree with me in my view of the case ; and yet there was
as strongly-marked festination as I have ever seen. The
gentleman could trot well, could mount a staircase without
much difiiculty, but walking slowly, or descending stairs,
troubled him greatly. According to some authors, this
symptom would, of itself, have been sufficient to contra-
indicate the existence of sclerosis, and to have placed the
disease among the neuroses. My views on this point have
already been expressed under the head of multiple cerebral
sclerosis.

J. F., a gentleman of this city, forty-two years of age,
consulted me November 29, 1870. On the 4th of July pre-
viously he had indulged rather freely in champagne, and
the following morning awoke with severe headache, ver-
tigo, and nausea. Although he recovered from this attack,
he never felt quite as well as before, and was frequently sub-
ject to headache and vertigo — symptomatic, as he thought,
of gastric disorder. About a month after his first symp-
toms he was suddenly conscious of a singular sensation
about his left eye, and on looking in the glass discovered
that the upper lid had dropped, and that he could not raise
it. This was about five o'clock in the afternoon, and by
ten that night the lid entirely covered the pupil. The fol-
lowing morning it was not so low, but he found that he saw
double. He continued to attribute all his troubles to the

MULTIPLE CEREBRO-SPINAL SCLEROSIS.

649

stomach, and began taking some quack remedy recom-
mended to him for dyspepsia.

In the course of a few days, feeling no better, he went
to the sea-shore, and while there noticed that his right arm
became weak, and that he frequently let things drop from
his hand. He had difficulty in shaving and in dressing him-
self, from inability to coordinate the muscles, and there was
numbness of the ends of the lino-ers. Durino- all this time
he had suffered more or less from headache, vertigo, and
double vision, and the ptosis still continued. Gradually the
left arm became involved, and, by the time the paresis in
this extremity was well established, the right arm was affect-
ed with tremor, but only when he attempted to execute
movements with it. Thus, as he said, he could place the
hand on a table and it would continue perfectly quiet ; but,
as soon as he took a pen to write, or even endeavored to
raise the hand from the table, it was seized with tremor.
The left arm soon became similarly affected, and eventually
the left leg lost strength and was rendered tremulous by
any attempt at muscular exertion. He noticed also, what,
as I afterward learned, his friends had perceived several
weeks before, that his articulation was imperfect, and that
it was necessary for him to make a mental effort to talk
distinctly.

He returned to the city about the middle of October,
and employed a " rubber " to restore, as he said, the circu-
lation to his limbs. Continuing to get worse, he consulted
me.

At this time there was festination. The speech was
syllabic and accentuated, the tongue and lips were paretic
and tremulous, there was nystagmus in both eyes, ptosis
and diplopia from paralysis of the left sixth nerve, and
dilated pupil of the right eye. There were also occasional
headache and vertigo, but not to the same extent as at first.

Both arms and the left leg were partially paralyzed.
He could not raise either upper extremity out from the side,

650

CEREBRO-SPINAL DISEASES.

owing to the complete paralysis of tlie deltoids, but he could
flex both forearms, and move his hands and fingers tolerably
well. There was no tremor while he refrained from usina:
them, but the least attempt at voluntary motion excited
them to agitation. The same was true of the left leg. Ex-
amination with the ophthalmoscope showed both optic disks
to be white, and the retinal vessels small and straight.

With the dynamometer he could only exert a pressure
of nine degrees with the right hand and eleven with the
left. The line made with the dynamograpli was descend-
ing, showing his inability to maintain, even for a short time,
a uniform muscular contraction.

There was no loss of sensibility, except in the upper ex-
tremities. He had occasionally suffered from pains in the
back, about the region of the shoulders.

The power over the sphincters was intact.

This gentleman could stand and walk as well with his
eyes shut as with them open. On rising from his chair,
which he did with difficulty, he always felt impelled to
take a few steps forward, which were a stagger rather than
a voluntary movement. In walking, the body was inclined
forward, and he went in a kind of jog-trot.

He attributed his disease to dissipation of all kinds, in
which opinion I expressed my concurrence.

Under treatment with galvanism, hyoscyamus, and chlo-
ride of barium, this patient has improved, but not as yet
sufficiently to warrant any strong hope of a permanent
cure.

A gentleman from the northern part of the State of
New York consulted me in January, 1871, and again in
March. His symptoms, though decided, were not very se-
vere in character. Gradually, however, there had been for
two years a loss of power supervening in the muscles of the
right side of the body, and lately ocular troubles had made
their appearance. Tremor, on making any voluntary move-
ment, was just beginning to appear when I last saw him.

MULTIPLE CEREBRO-SPINAL SCLEROSIS. 651

Its influence over liis handwriting is seen in the following

fac simile :

Fig. 28.

One patient, with multiple cerebro-spinal sclerosis, at-
tends the out-door department of the New York State
Hospital for Diseases of the Nervous System. He has
marked head-symptoms. And another, from Philadelphia,
who was supposed to be sulfering from cerebral disease, con-
sulted me a few days ago. In this case the affection prob-
ably resulted from a fall.

The remaining four cases, two of which are now under
treatment, do not present any such peculiar phenomena as
to warrant their histories being given in detail.

Causes. — Nothing very definite is known of the etiology
of the affection in question. It probably is induced by
such causes as give rise to the purely cerebral form of the
disease. Age does not, however, appear to exercise so im-
portant an influence. Four of my cases were over fifty
years, and one of them, the gentleman from Philadelphia,
was over sixty; six were over forty and under fifty, and one
was between thirty and forty. All were males but one.

In two cases, it was apparently caused by excessive
mental application, in one by anxiety, in one by a fall, in
two by dissipation. In the remaining five cases I could
discover no obvious cause. In none of them were there
rheumatic, syphilitic, or other morbid diathesis.

Diagnosis. — The facts of the tremor making its appear-
ance after the paralysis, and of its only — or, at least, with
rare exceptions, and then only in the latter stages of the
disease — being manifested when voluntary movements are
being made, will suffice to distinguish the cerebro-spinal
form of sclerosis from either of the other varieties. The
points to recollect are these : that, in simple cerebral scle-

652

CEREBRO-SPINAL DISEASES.

rosis, the tremor appears before the paralysis, and does not
depend on the voluntary contraction of muscles for its exci-
tation ; in simple spinal sclerosis there is no tremor at all.
I have already insisted on these distinctions in my remarks
on the other forms of sclerosis of the nervous centres.

Prognosis. — This is very generally unfavorable. In only
one case have I had reason to expect a cure. It often
happens that amendment very decided in its character
takes place soon after the beginning of the treatment with
galvanism and barium. This has been the case in every in-
stance of the disease that has been under my charge ; but
in only one has it been permanent. In those now under
treatment, there has as yet been no relapse ; but the time
is too short to speak with any confidence in regard to the
ultimate result.

Morbid Anatomy and Pathology. — The remarks made under
this head, when the cerebral and spinal forms of sclerosis
were being considered, apply to the cerebro-spinal variety,
Charcot * has considered the subject of sclerosis mainly in
its histological relations. The main points are — and these
have already been stated several times — that the morbid
process essentially consists in hypertrophy of the neuroglia
at the expense of the proper nerve-substance, aild that this
is a consequence of inflammatory action. In the present
form of the disease, the sclerosed tissue appears in the form
of plates or nodules in different parts of the brain and spi-
nal cord.

Treatment. — The means which I have found most efiica-
cious have been stated in the histories of the several cases
cited. They consist of galvanism, chloride of barium, and
hyoscyamus. The galvanism should be passed through the
brain and sympathetic nerve as recommended under the
head of multiple cerebral sclerosis (p. 298). In addition, a
strong cuiTcnt — that from sixty cells — should be passed

' Gazette des Hopitaux, Nos. 102, 103, 140, 141, 143, 1868,

MULTIPLE CEREBRO-SPINAL SCLEROSIS.

through the spinal cord, as recommended for antero-lateral
and posterior spinal sclerosis.

The chloride of barium should be given in solution in
water, in doses of a grain three times a day— the hyoscj-
amus in doses of from one to two teaspoonfuls of the tinc-
ture.

I have sometimes given the nitrate of silver in fourth-of-
a-grain doses, three times a day, and very generally recom-
mend cod-liver oil with each meal. Occasionally I have
administered iodide of potassium and the bichloride of mer-
cury, with the view of counteracting a possible syphilitic
diathesis.

Whatever measures are adopted should be continued for
several months at least, and, if the improvement persists, for
a much longer period.

CHAPTEK YIII.

A T HE T 0 S IS.

Under tlie name of athetosis ( 'A0€ro<i, without fixed po-
sition), I propose to describe an affection which, so far as I
know, has not heretofore attracted the attention of medical
writers, and of which two cases have come to my knowl-
edge. It is mainlj characterized hj an inability to retain
the fingers and toes in any position in which they may be
placed, and by their continual motion. From these phe-
nomena, I have applied the term athetosis to the disease,
having as yet had no opportunity of ascertaining by post-
mortem examination the nature of the lesion to which the
symptoms are due.

These symptoms will be evident from the following his-
tories :

J. P. R.,' aged thirty-three, a native of Holland, con-
sulted me September 13, 1869. His occupation was book-
binding, and he had the reputation, previous to his present
illness, of being a first-class workman. He was of intem-
perate habits. In 1860 he had an epileptic paroxysm, and,
since that time to the date of his first visit to me, had
had a fit about once in every six weeks. In 1865 he had
an attack of delirium tremens, and for six weeks thereafter
was unconscious, being more or less delirious during the
whole period.

' This patient was several times at my cliniques before the class of the
Bellevue Hospital Medical College, first in the autumn of 1869 and last in Janu-
ary, 1871.

ATHETOSIS.

655

Soon after recovering his intelligence, he noticed a slight
sensation of numbness in the whole of the right upper ex-
tremity, and in the toes of the same side. At the same
time severe pain appeared in these parts, and complex in-
voluntary movements ensued in the fingers and toes of the
same side.

At first the movements of the fingers were to some ex-
tent under the control of his will, especially when this was
strongly exerted, and assisted by his eyesight, and he could,
by placing his hand behind him, restrain them to a still
greater degree. He soon, however, found that his labor
was very much impeded, and he had gradually been re-
duced, from time to time, to work requiring less care than
the finishing, at which he had been very expert.

The right forearm, from the continual action of the mus-
cles, was much larger than the other ; and the muscles were
hard and developed, like those of a gymnast.

When told to close his hand, he held it out at arm's
length, clasped the wrist with the other hand, and, then ex-
erting all his power, succeeded, after at least half a minute,
in flexing the fingers, but instantaneously they opened again
and resumed their movements.

I treated him with galvanism, primary and induced, for
four months, without notable result. His fits were, however,
arrested with bromide of potassium.

His memory began to be impaired soon after his attack
of delirium tremens, and his intellect was manifestly weak-
ened when I first saw him.

January 17, 1871, he entered the New York State Hos-
pital for Diseases of the Nervous System, when the follow-
ing points, which I cite from the report of Dr. Cross, the
Eesident Physician, were noted :

The head is symmetrical, but is peculiar in shape — the
posterior portion rising to a much higher point than the
anterior, while the latter slopes downward and forward,
giving the cranium the form of that of a Flathead Indian.

656

CEREBRO-SPINAL DISEASES.

The special senses are normal. The intellect is somewhat
impaired, and his ideas are not so vivid at one time as at
another. His memory is much enfeebled. There is slight
tremor of both upper extremities, but there is no paralysis
of any part of his body. There are, however, involuntary
grotesque muscular movements of the fingers and toes of
the right side, and these are not those of simple flexion and
extension, but of more complicated form. They occur, not
only when he is awake, but also when he is asleep, and are
only restrained by certain positions, and by extraordinary
efforts of the will. Thus those of the fingers are arrested
when the wrist is firmly grasped by a strong hand, or when
it is less forcibly held in a vertical position. But, if the
arm be extended horizontally, the fingers at once begin their
movements. During their continuance the arm is hard and
rigid, and the calf of the leg is also in the same state of
tonic spasm while the toes are in motion. The movements
are somewhat paroxysmal, being worse at times than at
others. During the remissions the power of the will over
the muscles is more effective than when the paroxysms are
at their height.

Sensibility to touch, pain, tickling, and temperature, are
normal in all other parts of the body. There is slight trem-
ulousness of the tongue, but no difficulty of articulation.
There are no oscillatory movements of the eye-balls (nys-
tagmus).

The involuntary contractions of the fingers and toes do
not take place quickly, but slowly, apparently as if with
deliberation and with great force. The numbness and pain
in the arm, hand, leg, and foot, have increased in proportion
to the increase in the contractions.

The toes are not involved to the same degree as the fin-
gers. Position does not, however, afford the same relief to
them as to the fingers, and the spasms are more tonic in
character. The muscular development is greater in the
right arm and leg, from the almost continuous muscular

ATHETOSIS.

657

action. The toes are kept restrained to some extent by the
boot, but as soon as it is removed they become flexed and
take on their peculiar movements.

When, by a strong effort of the will, he succeeds for an
instant in arresting the movements in the hand, the little
finger at once becomes strongly abducted, the third finger
participates to some extent, the second finger is slightly
flexed, the index-finger is extended, and the thumb is ex-
tended to its very utmost. These are the positions in all
cases in which he succeeds in quieting the actions, and they
are well shown in the accompanying woodcut (Fig. 29)
taken from a photograph.

FiQ. 89.

On account of the severe pain in the whole arm, caused
by the spasms in the muscles, the patient is at times unable
to go to sleep until quite exhausted. On awaking, however,
after a few hours' repose, although the actions have contin-
ued during his sleep, they are not so severe as at any other
time through the day or night. This state of comparative
repose lasts for about half an hour.

His habits are bad. He boasts that he has often drunk
as many as sixty glasses of gin in a day, and it is therefore
doubtful whether the tremulousness observed in the tongue
42

658

CEREBRO-SPINAL DISEASES.

and the muscles generally is tlie effect of the disease, or of
drink, or of both combined. I have never, however, seen
him drunk, or even under the influence of liquor. His
mental faculties are decidedly more obtuse than when he
first came under my observation.

Under the use of the primary galvanic current to his
brain, spinal cord, and affected muscles, and the internal
use of chloride of barium, he is certainly improving, but I
have little hope of any permanent result being obtained.
His epileptic paroxysms are kept down with bromide of
potassium.

The second case occurred in the practice of Dr. J. C.
Hubbard, of Ashtabula, Ohio, who forwarded to me the
following excellent report, dated January 11, 1870, and two
photographs — one full length on a small scale, and another,
from which the woodcut. Fig. 30, has been engraved :

" H. S., aged thirty-nine years, a farmer by occupation,
married. His father and paternal grandfather were free
drinkers of ardent spirits. His only brother died of phthisis
pulmonalis, and I think he inherits a tubercular tendency
from his mother. The patient is short, muscular, is well
made, and has always had good health till about eight years
ago, when he had several attacks of headache, followed by
vertigo and loss of power to maintain the upright posture,
or to sit in a chair. After falling, he lost consciousness for
a few moments. He had three of these attacks in two
months.

" Three years after the last one, being five years and a
half ago, while at work on a hot day in the open air, he
lost consciousness and fell to the ground. This attack was
more severe than the preceding ones, and he was confined
to his bed three days. The headache was very severe, and
continued a week after he left his bed. Aphasia, and the
incoordination now affecting his right forearm and right leg,
were tlie sequence of this stroke. His powers of speech
were gradually reestablished in the course of six weeks, but

ATHETOSIS.

659

the impediment to normal voluntaiy muscular motion has
remained to this day.

"In June last [1869] he applied to me for relief from
cephalalgia, pain in the right side of the chest, cough, and
dyspnoea. He complained also of vertigo and of flashes of
light before his eyes. His memory and judgment were
slightly impaired, and he was gloomy and irritable.

" His utterance of most words was perfect, but he stam-
mered over at least one word in each sentence. It required
a good deal of effort for him to connect his ideas and his
sentences. He stumbled at monosyllabic words, such as
and^ then, to, at, and other conjunctions, but in a moment,
after considerable effort, he could speak these words and
conjoin his sentences correctly.

" On examining his right foot, I found that he had lost
the normal antagonizing force between the flexors and
extensors of the toes. The toes were ordinarily in a state
of flexion, so as to present their ends to the floor. He could
restore the balance in muscular action by a strong effort of
the will, pressing at the same time the sole hard upon the
ground, and drawing the foot backward a little. Soon,
however, the extensors would be wearied by their extra
work, and the toes would resume their abnormal position.
The foot is slightly inverted at every step, and it is not ex-
actly guided by the will. His gait is awkward — the foot
being set down with a kind of pawing motion, as in talipes
varus.

"A similar incoordination is observable in the right
hand and fingers. He cannot flex his fingers without the
aid of the opposite hand, but when it is closed the grasp is
as strong as ever. By an intense action of the will he can
keep his fist closed for a few moments, till the apparently
tired flexors give way. The little and ring fingers are but
partially extended, and are strongly abducted. The ab-
ductor minimi digiti, and the flexor brevis minimi digiti,
are hypertrophied, firm, hard, and in a state of contraction

660

CEKEBRO-SPINAL DISEASES.

most of the time, and the affected hand measures three-
fourths of an inch more around the palm than its fellow.
Tactile sensibility is as perfect in the affected limbs as in
the others. His muscular powers are good, and he thinks
he can walk twenty-five miles without injurious fatigue.
The temperature of the affected limbs is slightly lower than
that of the opposite ones. Has slight headache frequent-
ly, generally at evening ; sleep relieves it. He sleeps well
when undisturbed by pains in his limbs. Tongue clean and
tremulous. Has slow, moving pains, from the hand and
foot up to the body. They often last half a day, and are
worse at night. Has no pain, tenderness, or feeling of
weakness, in any part of the spine.

" He had no systematic treatment till last June. The
chest-symptoms referred to were owing to subacute bron-
chitis. A seton was inserted between the shoulders, and
iodide of potassium was administered for ten days. His
lungs being then better, phosphoric acid, cerium, cannabis
Indica, sulphate of quinine, and sulphate of iron, were given
till the 1st of December following. He then felt so much
better that he discontinued the medicines. The seton con-
tinued to discharge till the date of this communication
[January 11, 1870], and he presents at this time a very
marked improvement. His headache is not severe, he has
less pain in his limbs, and he speaks without hesitation.
By a strong effort of the will he can close his hand without
assistance. He came five miles on foot, in a driving snow-
storm, to see me to-day."

The accompanying woodcut (Fig. 30) is from one of Dr.
Hubbard's photographs. The resemblance to the condition
shown in Fig. 29 is very striking, and the histories of the
two cases are so nearly identical, in regard to all essential
points, as to leave no doubt that they describe instances of
the same disease. Dr. Hubbard's case was probably, when
he wrote the history, in a more advanced state than is mine
at the present time. The distortion of the hand is certainly

greater. In the other photograph, which is indistinct, the
toes are seen fully flexed.

Fig. 30.

The symptoms of athetosis are clearly indicated in the
foregoing histories. Both cases came on with epileptic
paroxysms — a feature accompanying other organic diseases
of the brain and spinal cord. In both there are similar
head-symptoms, tremulousness of the tongue, numbness on
the affected side, pains in the spasmodically-affected mus-
cles, and especially complex movements of the fingers and
toes, with a tendency to distortion. In neither case is there
any paralysis. Relative to the character of the lesion pro-
ducing these symptoms, and its exact seat, I am not yet
prepared to speak with any degree of certainty. The phe-
nomena indicate the implication of intra-cranial ganglia,
and the upper part of the spinal cord. The analogies of
the affection are with chorea and cerebro-spinal sclerosis,
but it is clearly neither of these diseases. One probable
seat of the morbid process is the corpus striatum.

I should not have incorporated these cases and remarks
in the present treatise, but with the hope of calling out the

662

CEREBRO-SPINAL DISEASES.

experience of others on tlie subject, by directing attention
to an affection whicb has probably heretofore been over-
looked or confounded with some other.*

' Since the foregoing chapter was written, my friend and colleague, Prof.
Fordyce Barker, to whom I showed the cuts and described the cases, has in-
formed me that several years ago he had an exactly similar case in his practice.

SECTION IV.

DISEASES OF l^EEYE-OELLS.

Under this section I propose to consider certain diseases
which are due to degeneration and atrophy of the cells in
intimate relation with nerve-roots, and which immediately
preside over the functions of the nerves arising from them.

CHAPTER I.

ATROPHY AND DISAPPEARANCE OF TROPHIC NERVE-CELLS
{PROGRESSIVE MUSCULAR ATROPHY).

Although cases of progressive muscular atrophy were
noticed by the older writers, the first systematic account of
the disease was given by Duchenne,' in 1849. In 1850 M.
Aran ' published his memoir, in which he gives the histo-
ries of eleven cases ; and three years subsequently Cruveil-
hier ' read a paper on the same subject before the Academic
de Medecine. About the same time other memoirs were
published on the subject.

' Atrophic musculaire avec transformation graisseuse. Memoires de I'Aca-
demie des Sciences, 1849.

* Recherches sur une Maladie non encore d^crite du Systeme musculaire.
Arch. Gen. de Med., 1850.

^ Sur la Paralysie musculaire progressive atrophique. Arch. Gen. de Med.,
1853.

664

DISEASES OF NERVE-CELLS.

But, although Cruveilhier was not the first to write upon
the affection in question, he was the first to describe it, and
Duchenne and Aran were aware that he had done so in his
lectures for several years. The disease is therefore some-
times called Cruveilhier's atrophy.

Symptoms. — The first symptom observed in the majority
of cases is loss of strength and dexterity in certain muscles
of the body. If these are in the lower extremities, the pa-
tient finds that he tires in walking sooner than he used to
do. If in the upper extremities, he experiences weakness
in the shoulder, arm, or hand, according to the muscles
affected.

Soon afterward pains simulating those of neuralgia are
felt in the paretic muscles, and in the majority of cases —
according to my experience in all — fibrillary contractions are
perceived. Thus, of twenty-nine cases of progressive mus-
cular atrophy which have been under my charge during the
past six years, these contractions formed a prominent feature
in every one. They consist of slight twitchings of separate
bundles of muscular fibres, and give the sensation of some-
thing alive being under the skin. They can often be seen,
especially when superficial fibres are involved, and they are
generally the a/oant courriers indicating the extension of tlie
disorder.

The loss of strength attracts the attention of the patient
to his limbs, and then he finds that the weakness is accom-
panied by atrophy. If, as is usually the case, the disease
begins in one of the upper extremities, the thenar and hypo-
thenar eminences very commonly give the first evidence of
atrophy. The ball of the thumb disappears, and the muscles
filling the space between the first and second metacarpal
bones — the adductor pollicis and the first interosseous — ^like-
wise shrink away. The whole outline of the metacarpal bone
of the thumb can thus very soon easily be made out.

The ball of the thumb is often the starting-point of the
disease, and, when this is not the case, it generally becomes

PROGRESSIVE MUSCULAR ATROPHY.

665

involved at some time or other in the course of the affection.
Of the twenty-nine cases occurring in mj experience, the
disease appeared first in the ball of the thumb in eight, and
eventually attacked this part in thirteen others. The upper
extremities were the original seat of the disease in seventeen
cases, the trunk in four, and the lower extremities in eight.
Whether the affection begins in an upper or lower extremity,
the tendency is for the opposite member to be next involved.

The physiognomy of progress in muscular atrophy is very
striking, particularly when the face or the hand is its seat.
No very well marked case of the former has come under
my observation, but it can readily be understood that the
change effected by the disappearance of the facial muscles
must be very evident. In the hand, the atrophy of the
muscles which give this member its plumpness, and enable
it to perform the complex movements of wliich the fingers
are capable, causes appearances which are easily recogniza-
ble. By the disappearance of the thenar and hypothenar
eminences, the skin over them hangs in loose folds, the
thumb falls by its own weight, and cannot be brought into
apposition with the index-finger — the palm of the hand is
hollowed out, and the metacarpal bones can be distinctly
seen and felt.

In the forearm, the situation of the disease can be readily
ascertained by the flattening produced by the disappear-
ance of the affected muscles, and in the arm and shoulder
the effects of the disease are still more evident. In two
cases, one of them sent to me by my friend Prof. Van Buren,
the disease had begun in the right deltoid, and had not ex-
tended beyond this muscle when the patients came under
my charge. In both, the shoulder was flattened, and the
head of the humerus and the acromion process could be dis-
tinctly seen. In another case it was limited to the trapezius
and scapular muscles of both sides.

In the lower extremity, the changes in the foot are not
so remarkable as the corresponding ones in the hand, but the

666

DISEASES OF NERVE-CELLS.

effects produced by the atrophy of the peroneal muscles, the
tibialis anticus, and those forming the calf of the leg, are very
striking. In the one case, the foot drops, and the patient
is obliged to bend the knee to a greater extent than usual
in order to make the toes clear the ground ; in the other,
the heel cannot be raised, and the ankle gives way with the
weight of the body. When the muscles on the anterior face
of the leg are in process of destruction, the forms of the tibia
and fibula can be distinguished, and the space between the
two bones is unfilled. The disappearance of the calf makes
the posterior aspect of the leg flat.

In the thighs the atrophy is also readily perceived, and
modifies very materially the gait of the patient. When the
extensors on the anterior face of the thigh are involved, the
leg cannot be thrown forward ; when the flexors are the seat,
the leg cannot be raised, and the whole member has to be
lifted up by the action of the flexors of the thigh on the
pelvis.

In the accompanying woodcut (Fig. 31), taken from a
photograph, there is an excellent representation of the
lower extremities of a patient affected with progressive mus-
cular atrophy. He formed the subject of my clinical
lecture on this disease at the Bellevue Hospital Medical
College, February 18, 1871, having the same day been ad-
mitted to the New York State Hospital for Diseases of the
Nervous System. The affection began with electric pains
in the legs, weakness, and head-symptoms, consisting of con-
fusion of ideas, vertigo, dimness of vision, headache, etc.
There was also numbness in both the lower and upper ex-
tremities. He partially recovered, but in May, 1867, there
was a return of the head-symptoms, the electric pains, and
numbness, to which were superadded cramps, fibrillary con-
tractions in both hands and legs, with tingling and twitch-
ing. In the course of three weeks he was obliged to use
crutches. From this time, he noticed the atrophy of the
muscles of both legs, and it has gradually extended till it

PROGRESSIVE MUSCULAR ATROPHY.

667

has involved the muscles of the lower third of both thighs.'
In the legs, the extensors are almost entirely destroyed, as
are also the gastrocnemii and solei. The figure, owing' to
the position of the patient when the photograph was taken,
does not show very well the effects of the disease in the legs^
but the atrophy in the thighs is distinctly indicated.

Fig. 31.

Besides the paralysis, which it must be clearly under-
stood results from the atrophy, and is directly proportional
to its extent, there may be contractions. These, when pres-
ent, are due to the fact that the atrophy has not attacked
all the muscles of an extremity simultaneously, or to a like

' From notes prepared by Dr. Cross, Resident Physician of the hospital.

668

DISEASES OF NERVE-CELLS.

degree, and consequently, the normal antagonism being de-
stroyed, distortions take place. When these occur in the
hand, they produce the main en griff e of Duchenne. Of
the twenty-nine cases occurring in my experience, seven
only had any distortions. In infantile paralysis, which is
shuilar in several respects to progressive muscular atrophy,
contractions and distortions are much more common.

The reflex movements are generally diminished, except
in the early stages, while the fibrillary contractions are pres-
ent, and the electric contractility diminishes with
the muscular tissue. The temperature of the alFected parts
is always lowered several degrees, and the capillary circula-
tion is languid.

The pupils are sometimes contracted from the implication
of nerve-cells in the cilio-spinal region of the cord. This was
the case in one or both eyes in four of my cases.

The course of the affection is slow, but in the great ma-
jority of cases it advances to a fatal termination. Death
takes place from the muscles of respiration becoming in-
volved, from exhaustion, or from some intercurrent affection.
Several of my cases have lasted over ten years.

In a recently-published memoir, MM. Duchenne and
Joftroy * have shown that glosso-labio-laryngeal paralysis is
sometimes complicated with progressive muscular atrophy,
and that this latter affection, implicating the muscles of the
tongue, the lips, and the veil of the palate, has hitherto been
confounded with the first-named disease. It differs from it,
however, in the essential fact, which is applicable to the
disorder appearing in other parts of the body, that the loss of
power is not the initial symptom, but results directly from
the diminution in the size of the muscles.

Causes. — Progressive muscular atrophy is not a disease of
old age. Only one of my cases was in a person over fifty ;
two were between forty and fifty, and twenty-six were under

' De I'Atrophie aigue et chronique des Cellules nerveuses de la Moelle et du
Bulbe rachidien. Arch, de Phys., No. 4, 1870, p. 499.

PROGRESSIVE MUSCULAR ATROPHY.

669

forty. Of these latter, two were between fifteen and twenty,
and two between eight and ten. The period of life at which
it appears to be most common is that extending from twenty-
five to thirty-five.

Sex is a strong predisposing cause. All of my cases
were in males. Roberts ' states that, of ninety-nine cases,
eighty-four were males, and only fifteen females. Other
authors have noted the great proclivity of males. The dif-
ference appears to be due to the greater severity of muscular
exertion required in many of the occupations of men.

Hereditary influence is a well-recognized predisposing
cause. Two of my cases sent to me by Br. Lincoln, of Wash-
ington City, were brothers, and nine others had relatives
affected with the disease.

The exciting cause is often impossible of detection. This
was the case in eighteen of the instances that have come
under my observation. Of the remaining eleven, injuries
of the spine were the cause in two ; exposure to cold and
dampness in three, and excessive muscular exertion in six.
Of these latter cases, one occurred in the person of a ballet-
dancer, the disease making its appearance first in both gas-
trocnemii muscles simultaneously ; one in a gentleman who
had overtasked the muscles of the upper extremities by severe
and long-continued exertion in rowing, the muscles about
the shoulders being affected ; in one, the muscles of the
right hand were first attacked, as the result of excessive use
of the pen in writing ; in one, it was induced by the occu-
pation, that of a bricklayer, requiring the patient to bear
the weight of his body, during his work, mainly on one leg—
the one attacked ; in one, it was apparently induced by
running a long distance ; and in one, it attacked the muscles
of the hand and forearm, beginning in the ball of the thumb
in a man whose occupation — faro-dealer — required him to
use his thumb and fore-finger in a peculiar way for many
hours at a time.

• An Essay on Wasting Palsy. London, 1858, p. 135.

670

DISEASES OF NERVE-CELLS.

Diagnosis. — The sharp, shooting, electric pains may, in the
beginning, cause progressive muscular atrophy to be mis-
taken for posterior spinal sclerosis, but the subsequent symp-
toms are so very obvious, that the error cannot be of long
duration, and are of such a character as to render the recog-
nition of the affection a matter of no difficulty.

Prognosis. — From what has been said, it will readily be
apprehended that progressive muscular atrophy is a very
serious disease ; indeed, it is one of the most progressive of
all the affections to which the term has been applied.

In only two cases have I succeeded in arresting the course
of the disease, and in restoring the atrophied muscles. One
of these was that of a highly-intelligent gentleman, formerly
an officer of the navy, but now a resident of this city, whose
case has already been referred to as having been induced by
rowing ; the other, was that of the patient sent to me by
Prof. Yan Buren, also previously mentioned, in whom the
affection was induced by cold, and which began in the right
deltoid muscle. Both of these patients were entirely cured,
regaining full muscular power.

In three other cases, which I saw before the disease had
advanced to a great extent, its progress was arrested, but
there has as yet been no restoration of the wasted muscles ;
in neither of these was there any probable cause of the
affection.

The existence of an hereditary tendency renders the
prognosis much more grave ; and the fact of the disease
having lasted a long time is also of unfavorable import.

Horbid Anatomy. — Investigations in regard to the morbid
anatomy of progressive muscular atrophy relate to the con-
dition of the muscles, of the nerves supplying them, and of
the centres from which the nerves are derived.

The atrophy of the muscles is due to the degeneration
and ultimate disappearance of the fibrillse. To the naked
eye they appear pale and attenuated. By microscopical
examination, it is seen that the transverse striae of the fibril-

PROGRESSIVE MUSCULAR ATROPHY.

671

Ise are in course of disappearance, and as the disease advances
they are perceived to fade away altogether. Eventually, the
longitudinal striee also disappear. At the same time, the
muscular fibrilloe break up into granules, and then undergo
regressive metamorphosis into fat. It is not uncommon to
see a bundle of fibrillse, in one part of which the transverse
striae only have vanished ; in another, the longitudinal ; in
another, the process of disintegration complete ; and in
another, oil-globules occupying their place. Fat-corpuscles
are frequently found deposited between the bundles of fibril-
Ise. After a time the fat disappears, and nothing is left of
the muscle but a cord of connective tissue made up of the
myolemma.

By means of the little trocar described in the introduc-
tion, I have frequently removed small pieces of atrophied
muscles during life, and submitted them to microscopical
examination.

The anterior roots of the spinal nerves ultimately dis-
tributed to the affected muscles are generally found atro-
phied, from the disappearance of a certain number of nerve-
tubes. This feature was first observed by Cruveilhier.

The spinal cord has been examined in cases of progres-
sive muscular atrophy by Bergmann, Meryon, Grull, Luys,
Lockhart Clarke, and others, with very different results ;
some of these observers finding no change whatever, and
others detecting notable variations from the normal struct-
ure. In three cases examined by Clarke,' disorganization
of the spinal cord, especially of the gray matter, was found,
with, in one case, deposit of amyloid corpuscles.

More recently Hayem,' and Charcot and J offroy,' have

1 Beale's Archives of Medicine, vol. iii., 1861; also, same, vol. iv. ; also,
British and Foreign Medico-Chirurgical Review, vol. xxx., 1862.

2 Note sur un cas d' Atrophic musculaire progressive, avec Lesions dela Mo-
bile. Archives de Physiologie, No. 2, 1869, p. 221, and No. 3, 1861, p. 391.

3 Deux Cas d' Atrophic musculaire progressive, avec Lesions de la Substance
grise et du Faisceaux antero-lateraux de la Moelle ^piniere. Arch, de Phys.,
Nos. 3 and 5, 1869.

6T2

DISEASES OF NERVE-CELLS.

studied the morbid anatomy of progressive muscular atrophy
with great care. In Hayem's case, the disease affected the
muscles of the upper extremities to such an extent as
to render them powerless from the shoulders down. The
patient died from paralysis of the diaphragm and of pneu-
monia.

On post-mortem examination, the spinal cord appeared
healthy to the naked eye. The anterior roots of the cervical
nerves were, however, notably atrophied. The most atten-
uated were those of the second, third, fourth, and fifth pairs.
The sympathetic was healthy. On microscopic examination
of the cord, the most marked characteristic was atrophy and
disappearance of the nerve-cells. In some portions there
were none to be seen, but there were large numbers of free
nuclei, and of cells containing many nuclei. The atrophy
of the nerve-cells, and of the anterior cornua of gray sub-
stance, was greatest at the level of the second and third cer-
vical nerves, and extended as low as the fifth cervical. This
region was that from which the nerves supplying the atro-
phied muscles were derived. In the dorsal and lumbar
regions there was no atrophy of nerve-cells or of nerve
roots.

A consideration of this case shows, as Hayem remarks,
that it is one which, during life, exhibited the usual symp-
toms of progressive muscular atrophy, and that, at the post-
mortem examination, lesions were found in the muscles in
the anterior roots of the nerve, and, above all, in the spinal
cord. The alterations from the healthy structure of the
cord consisted of

1. Abnormal vascularization with dilatation, and sclerosis
of the arterioles, and of the larger capillaries.

2. A more or less abundant exudation surrounding the
blood-vessels.

3. Multiplication of the elements of the interstitial tissue
(the neuroglia), and, finally, atrophy, and disappearance of a
very great number of the nerve-cells.

PROGRESSIVE MUSCULAR ATROPHY.

6T3

These facts point to the existence of chronic inflamma-
tion of the gray substance of the cord.

The two cases of MM. Charcot and Joffroj have also been
very carefully and thorouglily studied.

The chief features of the first case were, progressive mus-
cular atrophy, especially marked in the superior extremities;
atrophy of the muscles of the tongue and of the orbicularis
oris, and paralysis with rigidity of the inferior extremities.
The patient was a woman, and, becoming suddenly very
weak, died asphyxiated.

At the autopsy, the anterior roots, especially those of the
cervical region, w^ere found greatly atrophied and discolored.
The cord appeared healthy to the naked eye, except that at
the dorso-lumbar enlargement it was softened. On micro-
scopical examination, however, the nerve-tubes of the anterior
columns were discovered to be atrophied, a great number
being only represented by the axis cylinder while the con-
nective tissue was very much increased. The posterior col-
umns were not involved in the least.

In examining the gray substance of the cervical region,
the authors were struck with the extreme degree of atrophy
which the cells of the anterior cornua had undergone;
a large proportion of them had entirely disappeared,
leaving no trace behind them. The posterior cornua ap-
peared to exhibit all the qualities of the normal condi-
tion.

The alterations in the other regions of the cord were not
directly connected with the progressive muscular atrophy,
except as regards the medulla oblongata where the cells of
the nuclei of origin of the hypoglossal were found to be
atrophied, and even completely destroyed. In the second
case, similar structural changes were found.

The essential points in the morbid anatomy of progres-
sive muscular atrophy are no longer a matter of doubt.
The bearing of these points on the real nature of the disease
is next to be investigated.
43

674

DISEASES OF NERVE-CELLS.

Pathology. — At the outset of the inquiry relative to the
pathology of progressive muscular atrophy, the question
arises, Is the affection a disease primarily of the muscles or
of the nervous system ? From the fact that the wasting of
a muscle so frequently resulted from its excessive use, it
was, and still is, supposed by some pathologists that the
lesion is essentially one of the muscles, and that the nerves
and spinal cord are secondarily involved. But the conclu-
sion does not logically follow the premise, and observation
shows very conclusively that excessive use of a muscle ex-
hausts, not the muscle primarily, but that part of the ner-
vous centre from which the nerves come which supply that
muscle. The consequence of this exhaustion is atrophy
and disappearance of certain cells in intimate relation with
the roots of the nerves supplying the atrophied muscles.
By this theory is to be explained the occurrence of progres-
sive muscular atrophy in the legs of the ballet-dancer, and
the thumb of the faro-dealer, previously mentioned.

The destructive metamorphosis of the nerve-centre pro-
ceeds at a greater rate than its nutrition, owing to the ex-
treme demand made upon it by the muscles put in excessive
action, and hence their atrophy and disappearance.

A central disease being thus set up, it extends by con-
tiguity and involves those nerve-cells which are nearest.
These are the cells which supply the corresponding nerves
of the opposite side, and therefore it is that the disease, like
several others, tends to advance symmetrically, affecting
homonymous muscles.

Of course it frequently happens that progressive mus-
cular atrophy may originate from disease of the nerve-cells
without the muscle having been put to inordinate use. In
such cases the process is one of excessively chronic inflam-
mation.

One other very important question remains to be con-
sidered, and that relates to the physiological character of
the cells which have degenerated and have disappeared.

PROGRESSIVE MUSCULAR ATROPHY.

675

The spinal cord is admitted to be connected witli two
distinct faculties — motion and sensation. It is probable,
therefore, that there are at least two kinds of nerve-cells in
the gray substance of the cord, which, though alike in ana-
tomical characteristics, diflPer essentially in their functions.
One set is motor and one sensory. In those cases of spinal
paralysis involving motion, and in which there is atrophy
of nerve-cells, the motor cells are diseased ; in those in
which sensation is affected, and in which atrophy of nerve-
cells is discovered, the sensory cells are the ones impli-
cated.

Xow, progressive muscular atrophy, pure and uncom-
plicated, is unattended by derangements of sensation, and
unaccompanied by paralysis, except such loss of power as is
directly due to the diminution of the volume of the affected
muscles. The presumption is, therefore, that neither the
motor nor the sensory cells have disappeared or become
atrophied, and yet, on post-mortem examination, we find
that nerve-cells of soine kind have been diseased. The pre-
sumption is, and it is reasonable, that these are cells which
are specially connected with the nutrition of muscles — tro-
phic cells — and that progressive muscular atrophy is a symp-
tom indicating the existence of disease of the trophic cells.
The very existence of these cells is a matter of inference, but
in my opinion the argument in favor of the affirmative is
very much strengthened by the facts furnished by the morbid
anatomy of progressive muscular atrophy. Dr. Handfield
Jones' has recently written forcibly against the existence
of any special trophic nerves, and, by extension of reasoning,
trophic nerve-cells. But he was unaware of the more re-
cent researches of Duchenne and Joffroy,' upon which, in
accordance with these observers, I have based my views of

' Are there Special Trophic Nerves ? St. George's Hospital Reports, vol
iii., 1868, p. 89.

* De I'Atrophie aigue et chronique des Cellules nerveuses, etc. Archives de
Physiologie, No. 4, 1870, p. 499.

676

DISEASES OF NERVE-CELLS.

the pathology of progressive muscular atrophy, and to which
I have already alluded.

Treatment. — The treatment of progressive muscular atro-
phy is nothing without the use of the primary galvanic cur-
rent. This should be applied every alternate day to the
spinal cord, and to the sympathetic nerve. In the first in-
stance the current should be employed in the manner recom-
mended under the head of spinal anaemia ; in the latter the
positive pole should be applied to the cilio-spinal centre,
and the negative to the sympathetic nerve in the neck.
The current should be strong enough to give a decided sen-
sation— that from fifteen to twenty Smee's cells will usually
be sufiicient — and it should be applied for about ten min-
utes to the cord, and five to the sympathetic every alternate
day.

At the same time both the primary and induced currents
are efficacious in improving the nutrition of the atrophied
muscles, by applications made either directly, or to the nerves
which supply them.

For internal treatment, the means recommended for
posterior spinal sclerosis are the best. Iodide of potassium
. should of course be given when there is suspicion of syphi-
litic taint.

Hydrotherapeutics may be of service, and a few cases
have been reported of benefit therefrom.

The treatment recommended should be continued for
several weeks before any decided opinion can be given rela-
tive to its efficacy, and for many months before a cure can
be expected.

CHAPTEE II.

ATBOPET AND DISAPPEARANCE OF MOTOR NERVE-CELLS.

Although it is probable that there are several diseases
which consist of atrophy and disappearance of motor nerve-
cells, only one has been so far studied sufficiently as to war-
rant our associating it with the lesion in question, and that
is —

GLOSSO-LABIO-LAKTNGEAL PARALYSIS.

The first explicit account of this very remarkable disease
is that of Duchenne,' who, in consideration of the tendency
of the morbid process to advance unchecked, and of the
parts affected, designated it "progressive muscular paral-
ysis of the tongue, the veil of the palate, and the lips."
The consequences of this condition, as pointed out by Du-
chenne, are difficulties of articulation and of deglutition,
and at a late period of the disease frequent attacks of stran-
gulation, during one of which the patient may die ; or death
may result either from inanition or syncope.

But, although Duchenne was the first to give a system-
atic description of the affection, it was observed by Trous-
seau in 1841, just twenty years before the publication of
Duchenne's account, who recognized it as an affection he
had not previously seen, and who wrote a memorandum of
the existing phenomena.'' Trousseau named the disease
glosso-laryngeal paralysis, in his lecture on the subject, and

' De I'Electrisation localisee, etc., deuxieme Edition, Paris, 1861, p. 621.
2 Lectures on Clinical Medicine, Bazire's translation, p. 117.

678

DISEASES OF NERVE-CELLS.

this was afterward amplified by Duchenne into glosso-labio-
laryngeal paralysis. Many cases have been subsequently
reported, and descriptions of the affection given, but no
one has added any thing to the graphic symptomatology of
Duchenne. '

Eight cases of the disease have come under my observa-
tion during the past six years. I am enabled, therefore, to
describe it from my own observation of its phenomena.

Symptoms. — It rarely happens that patients seek medical
advice for the initial symptoms of the disease under notice.
We are therefore, in general, obliged to rely on their ac-
counts of the order and progress of the symptoms. In one
instance only — and this patient is still under treatment —
have I had the opportunity of observing a case from a very
early point in the course of the disease.

The first evidence of disease, which in the majority of
instances attracts the attention of the patient, is a slight
difficulty of articulation, due to a want of rapidity and ex-
actness in the movements of the tongue. This circumstance
occurred in seven of my cases. In the other the symptom
first noticed was a tendency in the lips to remain separate,
and the consequent necessity of using some degree of mental
action to keep them closed. In a short time the restraint in
the motions of the tongue becomes more distinctly marked,
and it is especially characterized by an inability to raise the
extremity to the roof of the mouth, or to press it against the
upper teeth. The words, therefore, which he experiences
most difficulty in pronouncing distinctly are those which
begin with lingual or dental consonants. The gutturals he
can articulate without trouble ; and the labials, except when
the affection begins in the lips, do not yet give him incon-
venience.

The next symptom to make its appearance is difficulty
of swallowing. The food is not promptly grasped by the
constrictor muscles of the pliarnyx, and the tongue does not
press it strongly against them. At times it enters the

GLOSSO-LABIO-LARYNGEAL PARALYSIS.

679

pharynx, and, not being carried onward by the muscles of
deglutition, may slip into the larynx and occasion suffoca-
tion. Liquids are especially difficult to swallow, and are
often ejected through the nostrils.

As the result of this paralysis of the muscles of deglu-
tition, the saliva, instead of being swallowed as fast as
secreted, accumulates in the mouth. Here it becomes
stringy from its mixture with the buccal mucus, and when
the patient opens his lips it runs out in streams. After a
time the orbicularis oris becomes so far paralyzed that the
lips cannot be kept closed without coptinual exertion, and
then the viscid saliva is constantly flowing out of the mouth.
In one of the cases mentioned as being under my charge,
there was from the first some flow of saliva from the mouth,
not apparently from any difficulty of swallowing, but from
the existing paralysis of the orbicularis oris allowing the
mouth to be almost constantly open. The other muscles
supplied by the facial nerve in the lower part of the face,
singularly enough, do not become involved. The food, it is
true, accumulates between the gums and the cheeks, and
has to" be removed with the finger, but this is not due to
any paralysis of the buccinator muscles, but to the want of
power in the tongue to move the alimentary bolus around
the cavity of the mouth.

When the disease is thus fully developed by the paralysis
of the tongue, the veil of the palate, and the lips, the pa-
tient presents a pitiable spectacle. He is unable to talk ;
his teeth are exposed, from the impossibility of closing his
mouth ; the saliva either runs in streams over the lower lip,
or he goes about with a handkerchief in his hand which he
uses to absorb the perpetual flow ; every attempt at deglu-
tition causes him the utmost distress, and puts him in
danger of his life from strangulation. When he opens his
mouth the glutinous saliva is seen hanging in viscid strings
from the roof, and his tongue, which he cannot move, lies
torpid like an inert mass of muscles as it is.

ggO DISEASES OF NERVE-CELLS.

The facial expression is well seen in the accompanying
woodcut (Fig. 32), made from a very accurate sketch of one

Fig. 33.

of my patients suffering from the disease in question, and
who entered my consulting-room with his handkerchief to
his mouth to absorb the streams of saliva which were flow-

The condition of the patient becomes still more pamful
from the implication of the respiratory muscles. The walls
of the chest become paralyzed, and he is unable not only to
breathe deeply, but to cough so as to keep the bronchial
tubes clear of accumulations of mucus. So feeble is the
respiratory power, that with all the effort he can make he
cannot blow out a candle.

GLOSSO-LABIO-LARYNGEAL PARALYSIS, ggl

And, besides the impossibility of articulation, tlie lar-
ynx becomes paralyzed at a later period of the disease,
and phonation becomes impossible. The patient is then
doomed to perpetual silence, even the power of whispering
being lost.

A remarkable fact is characteristic of many cases of
glosso-labio-laryngeal paralysis, and that is the tendency of
the morbid action to extend so as to implicate other nerve-
cells lower down in the spinal cord. But the cells thus
affected are not motor, but trophic, and as a consequence
the resulting condition is not paralysis but muscular atro-
phy. In none of my cases was there muscular atrophy in
any part of the body, but in one, to be presently referred to
more at length, there was incipient paralysis of the right
arm. The case was, therefore, similar to the one reported
by MM. Duchenne and Joffroy in their memoir already
cited.

Gradually, as the disease advances, the physical powers
of the patient yield. He becomes unable to walk, not from
paralysis, but from general debility, due to insufficient nu-
trition and imperfect respiration. His appetite remains
good, but he is afraid to take any more food than is barely
sufficient to sustain life, for experience has taught him that
suffering and danger are attendant on every attempt at
decflutition. At last he ceases to make the effort, and is fed
with liquid food through a stomach-tube. The saliva during
sleep runs down his throat, and fits of suffocation are the
result. Too weak to walk, he remains in bed, his head turned
to one side so as to allow free egress for the saliva, and he
dies either from asphyxia, from the cessation of the action of
the heart through the continued extension of the lesion to
the cells supplying the pneumogastric nerve, or from some
intercurrent affection.

Generally the mind remains clear to the last, but in a
very interesting instance of the disease sent to me by my
friend Dr. Fleming, of Pittsburg, this was not the case,

682

DISEASES OF NERVE-CELLS.

manifest dementia making its appearance toward tlie close.
The emotions are, however, almost invariably easily ex-
cited.

The first case of this disease coming under my observa-
tion was one sent to me, over three years ago, by my friend
Dr. Edward Bradley, of this city. The patient was a watch-
maker, and very intelligent. Though unable to speak a
word, I obtained a good deal of information from him rela-
tive to his disease by asking him questions, the answers to
which he wrote. The accompanying fac simile of one of
his written communications to me (Fig. 33) will, I doubt
not, prove of interest. It was made partially in answer to
questions, and partially at his own suggestion. The date
(March, 1847) was given in answer to my question when the
disease appeared, and the year mentioned is a mistake for
1867. As he states, there was a little trouble with his right
arm. This was of the nature of paralysis, there being no
muscular atrophy anywhere. The patient died about six
months after I saw him, the disease lasting a little over a
year.

The last case — the eighth — is a patient in the New York
State Hospital for Diseases of the ll^ervous System. In him
the affection began in the orbicularis oris, and has gradually
involved, though as yet slightly, the tongue and muscles of
deglutition. The left side was first involved, and then, a
few weeks afterward, the paralysis extended to the right.
There is nystagmus of both eyes. The mind is perfectly
clear. He formed the subject of a recent clinical lecture
on glosso-labio-laryngeal paralysis, which I delivered dur-
ing the session of 1870-'71, at the Bellevue Hospital Medi-
cal College. The case is further remarkable as occur-
ring in an exceptionably young person, the patient being
but thirty-two years of age. Duchenne * states that he has
never observed it in persons under forty. I subjoin a rep-

'De rfilectrisation localis4e, Paris, 1861, p. 648.

684 DISEASES OF NERVE-CELLS.

resentation of this patient (Fig. 34), taken from a photo-
graph. The paralysis of the orbicularis oris is evident,
although it is partly concealed by the mustache. At the
time it was taken the patient could swallow, but was con-
scious of a difficulty in beginning the act of deglutition.

Fig. 34.

Causes. — The etiology of glosso-labio-laryngeal paralysis
is very obscure. Duchenne attributes one of his cases to
mental anxiety ; two cases appeared to be due to syphilis
and rheumatism. In no other instance could he assign a
cause.

Of my own cases, one was apparently due to business
troubles resulting from petroleum speculatio;is ; and in one,
that of a gentleman from Kansas City, Missouri, who came
here to consult Prof. Sayre and myself, excessive application

GLOSSO-LABIO-LARNYGEAL PARALYSIS.

to business appeared to be the cause. In one other case,
that of a gentleman of this city, the disease was evidently
associated with syphilis. In none of the others could I
assign any cause. All of my patients were between the
ages of forty and sixty, except the one whose portrait has
just been given.

Diagnosis. — Attention to the account of the symptoms
given will prevent any mistake in diagnosis, as there is no
affection which resembles in its entirety the one under con-
sideration. In the very early stage, however, it may be
confounded with simple paralysis of the tongue ; or, if the
disease begins in the lips, as in the case cited, with facial
paralysis. In glossoplegia there are other symptoms of
cerebral disorder, and in facial paralysis the difficulty is not
confined to the lips.

It may possibly, in some cases, not be distinguished from
the general paralysis of the insane, which generally begins
with paralysis of the tongue and weakness of the lips. The
facts that this disease is manifested also by mental symptoms,
and that the paralysis gradually involves the other muscles
of the body, will suffice for making an exact diagnosis. In
facial diplegia the expression of countenance is very much
like that of a patient suffering from glosso-labio-laryngeal
paralysis, but here the resemblance ends, and careful exami-
nation shows even here many points of difference. It is
only necessary to state that the tongue is not paralyzed, and
that there is no difficulty of swallowing in double facial
paralysis.

In progressive muscular atrophy, attacking the tongue,
the veil of the palate, and the lips, a mistake might also be
made. But, as Duchenne remarks, progressive muscular
atrophy rarely begins in that way, and, when it does, other
muscles of the body, especially the thenar and hypothenar
eminences, will soon become involved. Charcot * has, how-
ever, recently reported a case in which progressive muscular

1 Archive de Phys., No. 2, 1870, p. 247.

686

DISEASES OF NERVE-CELLS.

atrophy was clearly combined with glosso-labio-laryngeal
paralysis, and in which, on post-mortem examination, though
the volume of the tongue was not diminished, the muscular
fibre had undergone degradation. In such a case, of course,
a complete diagnosis could only be made after death. In
ordinary progressive muscular atrophy, the fact previously
insisted upon, that the atrophy comes on before the paralysis,
is applicable here.

From diphtheritic paralysis, attacking the muscles of the
pharynx, glosso-labio-laryngeal paralysis is readily distin-
guished by inquiries relative to the history of the case, and
by the fact that the tongue is not involved in the first-
named disorder.

Prognosis. — There is no instance on record of a cure. All
my patients affected with the disease are dead but one, and
with him the affection is slowly advancing. Ameliorations
may certainly be produced, but probably no cure. The
average duration of the disease is about two years.

Morbid Anatomy. — Previous to the very recent researches
which have given us a clear insight into the morbid anatomy
of glosso-labio-laryngeal paralysis, the lesions, detected by
several observers, were atrophy of the roots of the hypo-
glossal, facial, spinal accessory, and pneumogastric nerves.
But late investigations have shown that the lesions of the
nerve-roots are secondary to others more central in their
situation.

It has already been shown, under the head of progressive
muscular atrophy, that the morbid process in that disease
consists of atrophy and disappearance of nerve-cells forming
the nuclei of origin of certain nerves. Yery minute exami-
nations, made in the cases of persons dying of the disease
under notice, show very clearly that it also consists of
atrophy and disappearance of nerve-cells.

Thus, in the case just cited from Charcot, the post-mortem
examination revealed the fact of atrophy of the nerve-roots
supplying the paralyzed muscles, and microscopical investi-

GLOSSO-LABIO-LARTNGEAL PARALYSIS.

687

gation showed that the nerve-cells in relation with the fila-
ments of origin of the hypoglossal, the spinal accessory, the
pnenmogastrie, and the facial were altered, and had many of
them disappeared. In the case which Dnchenne has made
the basis of some original views on the subject of atrophy of
nerve-cells, and which has already been cited several times,
it was found that the cells constituting the nuclei of origin
of the hypoglossal, the facial, the spinal accessory, and the
pneumogastric, had become atrophied, and had disappeared
to a remarkable extent.

It may, therefore, be considered as satisfactorily deter-
mined, that the essential lesion in glosso-labio-laryngeal
paralysis is found in the medulla oblongata and upper part
of the spinal cord, and that it consists of atrophy and dis-
appearance of certain nerve-cells constituting the nuclei of
origin of the hypoglossal, the facial, the spinal accessory, and
the pneumogastric nerves.

Pathology. — What is the nature of the nerve-cells which
have been diseased ? In progressive muscular atrophy, we
saw that there was ample reason for supposing them to be
cells that especially presided over the function of nutrition —
trophic cells ; for that disease is one in which the lesion, so
far as the muscles are concerned, consists of deficient nutri-
tion. Glosso-labio-laryngeal paralysis is not, however, a
disease in which the muscles are defectively nourished, but
one the essential feature of which is paralysis. It is reason-
able, therefore, to suppose, with Duchenne, that the nerve-
cells which have become diseased are motor cells. As re-
gards the relation of the symptoms observed to the known
distribution and functions of the nerves concerned, there is
no difficulty. The affection of the hypoglossal causes the
paralysis of the tongue, and the consequent impossibility of
articulation, and of moving the food in the mouth. The im-
plication of the facial accounts for the paralysis of the lips
and the muscles of the veil of the palate, and the resultant
impossibility of sounding certain letters, and of swallowing.

688

DISEASES or NERVE-CELLS.

The extension to the spinal accessory explains the paraly-
sis of the larynx, the loss of phonation, and the feebleness
of respiration ; and death, when it takes place as it some-
times does from the sudden stopj)age of the heart's action, is
due to the implication of the pneumogastric, to which cause
other paralyses of the muscles of animal life are to be as-
cribed.

Treatment. — From what was said relative to the prog-
nosis, it will have been perceived that there is not much
to expect from treatment. I have, however, occasionally
produced good results which have, for a time, at least, ren-
dered the condition of the patient more tolerable. Thus,
the first patient who came under my care was much relieved
by faradization of the paralyzed muscles. He improved very
much in his ability to swallow, and in power over his tongue
and lips. These ameliorations were not permanent. In the
case of the gentleman from Pittsburg, as well as in all the
other cases but one, simitar treatment, together with the use
of the primary galvanic current and phosphorus, was with-
out the least effect. In this latter case, which is now under
treatment, some benefit has apparently resulted. The course
of the disease is certainly less rapid than before treatment
was begun, but it is nevertheless, in my opinion, slowly ad-
vancing.

CHAPTEE III.

ATROPHY AND DISAPPEARANCE OF MOTOR AND TROPEIO
NERVE-CELLS.

OKGANIC INFAirriLE PARALYSIS.

Under the name of organic infantile paralysis, I have
described at length ' a form of paralysis occurring in young
children, previously described by Eilliet and Barthez as the
Paralysie essentielle de Venfarhce, and by Duchenne' as
Paralysis atrophique graisseuse de Venfance. Previous
to the writings of these authors, the affection in question
was not distinctly recognized as a separate disease, but was
confounded with a much less serious disorder, probably
belonging to the class already considered under the head of
anaemia of the anterior columns of the spinal cord. The
tendency in the present affection to muscular atrophy, and
the permanent character of the paralysis, are phenomena
which sufficiently distinguish it from the temporary paralysis
referred to.

Symptoms. — Organic infantile paralysis is generally pre-
ceded by febrile excitement and pain in the back. This pain
marks the seat of the disease in the spinal cord to which the
paralysis of the muscles is due. These symptoms last for a
few days, or they may be so slight as in very young children
not to attract attention.

1 JouRNAi, OF Psychological Mkdicine, No. 1, 186Y, p. 49. Also, my trans-
lation of Meyer's Electricity in its Relations to Practical Medicine. New York
1870, p. 228, note.

Traite, clinique et pratique, des maladies de I'enfance. Paris, 1853, t. ii.
p. 335. ' '

690

DISEASES OF NERVE-CELLS.

Sometimes tlie paralysis is readily observed from the
first, both by the extent and intensity ; at others, it is not
perceived till some one notices that the child does not use
one hand or kick with one leg. The age of the patient of
course exercises considerable influence on the question of as-
certaining the existence of the paralysis at an early period.

The temperature of the affected limbs is always much
lower than that of the corresponding sound ones. The dif-
ference is sometimes as much as eight or ten degrees, though
generally it is not more than five. If, under appropriate
treatment, amendment takes place, the first indication is
shown by the return of the temperature toward the natural
standard. It thus becomes important to have some means
by which a very slight increase of heat may be noticed. A
delicate thermometer graduated to tenths of a degree will
generally suffice, but much more exact indications may be
obtained by Becquerel's disks, which are placed in commu-
nication with a galvanometer. These disks consist of a very
thin plate of copper, about the size of a half dime, soldered
to a thin rod of bismuth. The latter is contained in a small
tube of hard rubber furnished with a handle. The disks
are two in number : one is placed on the sound limb, the
other on the corresponding part of the paralyzed limb. Both
are in connection, by delicate silk-covered wire, with the poles
of a galvanometer. If the temperature of both limbs be the
same, the needle of the galvanometer remains quiet. If
either be warmer than the other, the needle is deflected to
the north or the south, according as one or the other limb
has the higher temperature. By this apparatus, very much
less than the hundredth of a degree of temperature can be
determined with absolute certainty.

Sensibility is not materially, if at all, lessened, though
the reflex excitability is diminished, and often entirely abol-
ished, from the very first.

But the most obvious and important change is that which
takes place in the paralyzed muscles, and which consists of

ORGANIC INFANTILE PARALYSIS.

691

atrophy and degeneration of the proper tissue. The process
is very similar to that which constitutes the essential feature
of progressive muscular atrophy, although it is far more
rapid in its progress.

With this atrophy, the electric contractility of the muscles
disappears, although it has begun to be lost at an earlier
period, and hence the strongest induced currents fail to
cause the slightest contraction, and in some cases even pow-
erful primary currents are equally ineflScacious. Owing to
the disturbance in the normal equilibrium of the muscles
consequent on the paralysis, distortions of various kinds are
produced, and hence we have the most important causes of
club-feet.

Causes. — Little is known of the etiology of organic in-
fantile paralysis. In two cases under my observation, oc-
curring in brothers, it was apparently induced by the nurse
allowing the infants to lie on the damp ground for an hour
or more ; in several other cases, it came on while the children
were suffering from teething, and in others it has followed
diseases of various kinds, such as whooping-cough, measles,
scarlet fever, etc. In the great majority of the cases that
have come under my observation, no cause could be reason-
ably assigned.

Diagnosis. — The symptoms of organic infantile paralysis
are so characteristic, that there is no danger of its being
mistaken for any other affection.

Prognosis. — The prognosis depends very much upon the
fact as to whether the disease has advanced so far as to have
resulted in the abolition of the electric contractility of the
affected muscles. If this is lost to the induced current, the
cure will be difficult, and the treatment protracted ; if the
primary current is also powerless, a cure is impossible. I
believe I was the first to use the primary current in the
treatment of infantile paralysis, and to insist on its great
value as a curative agent, and as an element in the prog-

692

DISEASES OF NERVE-CELLS.

nosis.* If the muscles can be made to contract with either
the induced or primary currents, the cure is merely a matter
of time and patience.

Morbid Anatomy. — The morbid anatomy of organic infan-
tile paralysis is to be studied in the spinal cord, the nerves,
and the muscles. As regards the latter, there has been a
tolerable accord among observers, but there has been no ap-
proach to uniformity relative to the state of the spinal cord
and nerves. The general opinion has, perhaps, been that
there is no appreciable alteration. In one case in which I
had the opportunity of making a post-mortem examination,
and of inspecting the condition of the cord, I found a cicatrix
partially filled with a very small clot. The paralysis in this
instance was situated in the left lower extremity, and had
begun four years previously. The lesion existed in the
lower part of the dorsal region in the left anterior column.
ISTo microscopical examination was made ; but, since the
remarkable series of observations on the minute anatomy
of the spinal cord, made by Dr. Lockhart Clarke, a new
impetus has been given to studies of its morbid anatomy,
and hence the results obtained in researches into the morbid
anatomy of progressive muscular atrophy, glosso-labio-laryn-
geal paralysis, locomotor ataxia, and other spinal affections.
In organic infantile paralysis some recent observations have
thrown light on its nature. MM. Charcot and Joffroy have
had the opportunity of making a minute investigation in a
case of infantile paralysis existing in a patient in the Salpe-
triere — a woman who died at the age of forty.

The disease began when she was seven years old. At
first all the limbs were paralyzed, but by the end of a year
the upper extremities had in a measure regained their
power. The lower extremities remained nearly altogether
without the power of motion.

On post-mortem examination, the spinal cord was found
to be affected from the cervical to the lumbar enlargement.
1 New York Medical Journax, December, 1865.

ORGANIC INFANTILE PARALYSIS.

693

The alterations were chiefly in the gray matter, and espe-
cially in the anterior cornua. These were atrophied and
distorted, and the cells had disappeared to a very great ex-
tent. The posterior cornua, though involved, were affected
to a much less extent.

The anterior roots of the nerves coming from the dis-
eased portions of the cord were atrophied.

The paralyzed muscles had undergone fatty transforma-
tion, and the tibrilloB had, to a great extent, disappeared.

From these examinations we perceive that the lesion in
organic infantile paralysis consists essentially of atrophy and
disappearance of nerve-cells.

My own observations in the direction of the morbid
anatomy of the disease under notice have been mainly
limited to the condition of the muscles during life.

The nature of the morbid process is well shown in the
accompanying woodcuts, made from my own drawings of
the microscopical appearances of portions of diseased mus-
cles removed by Duchenne's trocar. Fig. 35 represents a
portion of the upper part of the tibialis anticus muscle of a

Fig. 35.

boy who had suffered from organic infantile paralysis for
over two years. Oil-globules are seen along the course of
the fibrillae. These latter are irregular and torn, and the
transverse striae are becoming dim.

In Fig. 36 a still more advanced stage is shown. This
cut represents a portion of the same muscle taken from the

694

DISEASES OF NERVE-CELLS.

lower part. The transverse striae have nearly disappeared,
oil-globules are seen in large numbers, and fat-corpuscles
are also abundant.

Fig. 36.

In Fig. 37 the progress of the disease is well shown.

Fig. 37.

The upper margin of the specimen is a mass of fat-globules,
and throughout the whole the transverse strige are absent.

In Fig. 38 is shown a portion taken from the same mus-
cle one month after the preceding specimens were removed.

Fig. 38.

ORGANIC INFANTILE PARALYSIS.

695

The transverse strise are entirely gone, and the muscle is a
mass of oil-globules and fat-vesicles.

Fig. 39 represents a piece of the same muscle six weeks
later. It is now nothing more than a mass of connective

Fig. 39.

tissue, the fat being almost entirely absorbed ; no transverse
or longitudinal strise are to be perceived.

But there is not, as Duchenne affirms, this degeneration
in every case of organic infantile paralysis. In two cases,
which had lasted over four years, I found the structure of
the muscle unchanged. There were atrophy, loss of elec-
tric contractility, and reduction of temperature, but every
specimen of the affected muscles that I examined showed
no change from the normal character. In every other re-
spect the symptoms were similar to those observed in ordi-
nary cases of the disease. Improvement was very slow, but
finally every muscle except the rectus femoris in one, and
the tibialis anticus in the other, recovered, and the children
were enabled to walk. The affection in both cases was con-
lined to the left lower extremity.

I am hence led to the conclusion that fatty degeneration
of muscles, though the ordinary result of organic infantile
paralysis, is not an invariable consequence.'

Pathology. — It must be borne in mind that the disease
under consideration is a paralysis primarily, and not an

» Journal of Psychological Medicine, No. 1, 1867, p. 51. Since the obser.
vations then published, other observers have arrived at the same conclusion.

696

DISEASES OF NERVE-CELLS.

atrophy. There can be no doubt, therefore, that Duchenne
is wrong in considering it, as he does, an acute form of pro-
gressive muscular atrophy. In the first stage, the motor
cells only are probably involved; in the latter, when the
atrophy begins, the trophic cells are the starting-point. The
disease is therefore, in my opinion, one which consists of
atrophy, and disappearance of both motor and trophic cells,
and hence we have, as its manifestations, paralysis and
atrophy, each independent of the other.

Moreover, there is no tendency in organic infantile pa-
ralysis to extend beyond the limits of the muscles first par-
alyzed ; on the contrary, there is a strong disposition toward
repair of the spinal lesion, and the restoration of motility
before the supervention of atrophy. These two features
serve to increase the distinction between organic infantile
paralysis and progressive muscular atrophy.

Treatment. — The treatment of the disease consists in the
use of general and local means. Of these, the latter are of
much the greater importance, especially after the first or
febrile stage has subsided, and the disease is chiefly mani-
fested in the paralyzed or atrophic condition of the muscles.
During the acute stage, there is nothing of so much efficacy
as rest in bed. I know of no medicines which are capable
of producing any specific action on the spinafl cord at this
time, and, even after the spinal affection has become more
chronic, the means mainly to be relied upon are those which
are applicable to the local trouble of the muscles.

Strychnia is useful because it is capable of acting as a
general stimulant to the nervous system, and is, moreover, a
tonic to the muscles. I generally prescribe it in union with
iron and phosphoric acid, according to the following formula :

Strychnise buI. gr. j., ferri pyrophosph. 3ss., acidi phos-
phorici ^ss., syrupus zingiberis §iiiss. M. ft. mist. Dose,
a teaspoonful or less, according to the age of the child.

The immediately local means of treatment are those
which are calculated to promote the nutrition of the muscles,

ORGANIC INFANTILE PARALYSIS.

697

and restore or augment their contractile power. Tlie first
end is effected by causing a greater amount of blood to
flow through the diseased parts, the second is best accom-
plished by the persistent use of electricity, and active and
passive exercise.

Under the first head are embraced . heat, friction, and
kneadino;.

Heat is best applied by means of hot water. A tempera-
ture of from 110° to 120° Fahr. may be used, and the limb
should be thoroughly immersed, and allowed to remain so
for half an hour ; salt may be added to the water, with the
view of augmenting the stimulant effect.

Frictions with a dry towel, a flesh-brush, or the hand,
are also exceedingly useful ; they should be practised several
times in the course of the day, to the extent of reddening the
skin.

Kneading the muscles affords a means of exercising them,
and of increasing the amount of blood in the vessels. They
should be pinched firmly between the fingers of both hands
to the extent of producing some little pain ; every paralyzed
muscle should be gone over in this way daily.

Tinder the second head, electricity comes first. If the
induced current will produce contractions in the affected
muscles, it should be employed ; but if, as often happens, it
should fail to do so, the primary current must be brought
into service. In the communication ' already cited, I called
attention to this valuable agent in the treatment of organic
infantile paralysis. If a contraction can be induced by it,
recovery is merely a matter of time.

During the period from December, 1865, to December,
1870, I have treated ninety-eight cases of organic infantile
paralysis. Of these, the disease was so far advanced in eleven,
as to render it very evident, after thorough examination, that
success was out of the question. In the remaining eighty-
seven, no contractions could be caused in the affected mus-
' New York Medical Journal, December, 1865.

698

DISEASES OF NERVE-CELLS.

cles by the strongest induced currents in thirty-nine ; while
in all of these the primary current produced decided con-
tractions. Of tlie eighty-seven cases, fourteen were entirely
cured ; twenty-eight were greatly improved ; thirty slightly
improved, and the remainder — fifteen — discontinued treat-
ment before sufficient time had elapsed to ascertain the
effect.

At the best, however, the treatment must be of long
duration, and even when the muscles are entirely restored
they must be reeducated to the j)erformance of their func-
tions. Few parents, comparatively, have the patience to
wait and to devote the necessary time to doing their part
of the work ; unless there is a reasonable assurance in regard
to these points, it is better not to undertake the case. It is
not, except in recent cases, a matter of days, or of weeks, but
of months, and sometimes of years.

But, even when fatty degeneration is going on, the disease
may be arrested by the proper use of the direct current. Fig.
40 shows the appearance of a portion of muscle as exam-

Fm. 40.

ined by the microscope, October 21, 1866. This specimen
was removed from the belly of the gastrocnemius muscle
before any treatment whatever had been employed, and
after the disease had existed, with gradually-advancing atro-
phy, for about four and a half months.

ORGANIC INFANTILE PARALYSIS.

699

Fig. 41 represents a piece of the same muscle from
the same part, on December 3d, six weeks after the treat-
ment was begun. In the first, oil-globules are seen to have
displaced the muscular tissue to a great extent ; the trans-

FiG. 41.

verse striae have disappeared entirely from some parts, and
are faintly seen even where they are present. In the second,
the quantity of fat is perceived to be very much lessened,
and the striae are much more numerous and distinct. This
case, which was one of paralysis of the left leg and foot,
entirely recovered.

After the power of the will is to some extent restored
over the muscles, the induced current may be used with more
advantage than the direct.

Along with the electricity, passive motions of the joints
should be made, and the child should be encouraged to direct
the will to the aflPected. muscles as often and as powerfully
as possible.

HYPEKTKOPHY OF MUSCULAR CONNECTIVE TISSUE.

The first to call attention to this affection was Du-
chenne,' who described it under the name ai jparajplegie hy-
jpertrojg'Tiique de Venfance de cause cerebrate. He has since
designated it jparalysie pseudo-hypertrophique, ou myo-scle-
rosique^ Jaccoud ' calls it sclerose musculaire progresswe

' De r^lectrisation localis^e, etc., Paris, 1861, p. 353.
* Archives Generales, etc., 1868. ' Op. cit., p. 365.

700

DISEASES OF NERVE-CELLS.

(progressive muscular sclerosis). Dr. Foster' terms it pa-
ralysis with apparent muscular hypertrophy.

Regarding the affection as consisting essentially in dis-
ease of the motor and trophic nerve-cells, and as being mani-
fested by hypertrophy of the muscular connective tissue at
the expense of the muscular fibres, I have provisionally
placed it in the present chapter. My personal acquaintance
with the disease is limited to one case, and I am of the
opinion that it is exceedingly rare in this country — one other
case only having been reported, by Drs. "William Ingalls and
S. G. Webber, of Boston," the latter of whom, in connection
with the history of the case, has written a very excellent
memoir on the disease.

Symptoms. — The first symptom observed is weakness in
the lower extremities, which causes an inability to stand
steadily, or to walk without stumbling or falling. The legs
are separated widely in standing or walking, and thus a pe-
culiar character is given to the gait, which somewhat resem-
bles that of a duck.

Very soon an enlargement of the calf of one of the legs
is perceived, the other before long is affected, and then the
muscles of the thighs and gluteal region become involved.

As the child stands or walks, a remarkable incurvation
of the spine in the lumbo-sacral region is perceived, so that,
if, as Duchenne remarks, a plumb-line be allowed to fall
from the most posterior spinous process of a vertebra, it
passes far behind the sacrum. He considers this phenome-
non to be due to weakness of the erector muscles of the
spine. The muscles of the trunk may become involved, as
may also those of the upper extremities — the deltoids being
the first affected in the majority of cases, and the progress
being much slower than in the lower extremities.

With the advance of the hypertrophy the paralysis

' Lancet, May 8, 1869.

* A case of Progressive Muscular Sclerosis, with a Paper on the same. Bos-
ton Medical and Surgical Journal, November 17, 1870.

ORGANIC INFANTILE PARALYSIS.

701

becomes more strongly marked, and finally the child is
confined to the recumbent posture. Distortions from dis-
turbance of muscular equilibrium may take place, and the
attempt at flexion or extension becomes painful.

Electric contractility is always lessened to the induced
current, but, according to some observers, is increased to
the primary current. In the case under my care, both cur-
rents failed to cause the normal amount of contraction in
the affected muscles. The cutaneous sensibility is not
affected.

The course of the disease is slow, its average duration
being about five or six years. As it advances, there are
symptoms indicating loss of mental power, and cerebral
disturbance is sometimes also indicated by ocular troubles
and pain in the head.

Death takes place by the respiratory muscles becoming
implicated, by exhaustion, or by some intercurrent affec-
tion.

In the case which came under my notice March 7, 1871,
and which is still under treatment, the patient, a boy seven
years old, exhibited great disinclination to learn to walk.
At three years of age he could not stand longer than a few
seconds, and even for this time he was obliged to spread the
legs apart and to hold on to some article of furniture. It
was not noticed till he was five years old that his legs were
larger than was natural. The hypertrophy began in the
right calf, then attacked the left, and then the glutei mus-
cles, before affecting the muscles of the thighs. The upper
extremities are as yet unaffected, but the spinal curve is
very evident. The accompanying woodcuts (Figs. 42 and
43) give a posterior and profile view of this boy, from pho-
tographs. He was unable to stand alone while the photo-
graphs were being taken, but the spinal curve is well shown,
and the positions are those he spontaneously assumed.

Causes. — The disease is almost entirely confined to in-
fancy, and boys are more liable than girls. From a table

702 DISEASES OF NERVE-CELLS.

containing analysis of forty-one cases given by Dr. "Webber
in his paper already cited, it appears that in one case the
patient was twenty-six when the disease began, in one a few

Fig. 42. Fig. 43.

years under forty, and in one about twenty-eight. It is
possible that those cases occurring in persons of adult age
were instances of the simple hypertrophy of an extremity,

ORGANIC INFANTILE PARALYSIS.

703

such as the case reported by Mr. Maunder/ and similar ones
by other authors.

All the cases collected by Dr. Webber, except five, oc-
curred in males.

There is some reason to suspect hereditary influence as
an occasional predisposing cause.

Of the exciting causes nothing is known with any cer-
tainty.

Diagnosis. — The only affection at all resembling that un-
der consideration is simple muscular hypertrophy due to an
excessive supply of blood being sent to a part of the body.
The histories and phenomena of the two disorders are,
however, so very different, that I do not see how any error
can arise in making a diagnosis between them.

Prognosis. — The prognosis is unfavorable. A case of re-
covery is related by Duchenne, and other observers have
reported improvements, but the tendency is to death, though
life may be prolonged many years notwithstanding the
gradual advance of the disease.

Morbid Anatomy. — The spinal cord has only been exam-
ined in one case — that of Eulenburg, by Cohnlieim — and
no lesion was discovered. We are not, from this negative
result, to infer that changes had not taken place. About
the same time observers were everywhere declaring that in
progressive muscular atrophy, organic infantile paralysis,
and locomotor ataxia, there were no central lesions. I have
no doubt that careful microscopic examination of the spinal
cord, after the manner of Dr. Lockhart Clarke, will result
in the detection of atrophy and degeneration of nerve-cells
in cases of hypertrophy of muscular connective tissue.

Examination of the muscles, however, gives very uni-
form results. The proper tissue is atrophied and has under-
gone degeneration, while the connective tissue has not only
taken its place, but has undergone extensive proliferation.

In the case under my care I have made repeated exami-

> Medical Times and Gazette, March 27, 186ff

704

DISEASES OF NERVE-CELLS.

nations, removing the muscle with the trocar of Duchenne.
The accompanying woodcut (Fig. 44) represents the histo-

logical character of a portion of muscle taken from the left
gastrocnemius. The transverse striae are seen to have
entirely disappeared, the fibrillse are in a state of disin-
tegration, and the connective tissue is present in large
amount.

Pathology. — The main point of difference between hyper-
trophy of the muscular connective tissue and organic infan-
tile paralysis is that, in the former there is muscular atrophy
with connective-tissue hypertrophy, while the latter is atro-
phy without this complication. It is highly probable that
the lesion in the fonner is analogous to that in the latter
disease. They are certainly not identical, but the phe-
nomena of hypertrophy of the muscular connective tissue
indicate the lesion to be situated in the motor and trophic
cells.

Treatment. — The induced current has been useful- in Du-
chenne's hands, and, as stated, he has reported one cure.
He combines with it shampooing or kneading, and hydro-
therapeutics. The primary current to the spinal cord and
sympathetic nerve has been used by Benedikt' in five cases,

Fig. 44.

' Electrotherapie, Wien, 1868, p. 186.

ORGANIC INFANTILE PARALYSIS.

705

and in three of them the induced current was applied to
the hypertrophied muscles. Three cases were improved.

In my case the primary current is being used to the
spinal cord and sympathetic nerve, and the induced to the
affected muscles. These latter are also well kneaded every
day. At the end of three weeks I am unable to detect any
improvement.

CHAPTEE lY.

FUNCTIONAL DERANGEMENTS OF MOTOR NERVE-CELLS.
PARALYSIS AGITAN8.

Under the term paralysis agitans, several affections have
been included which are very different in character. 1
have already considered two of them — multiple cerebral
sclerosis and cerebro-spinal sclerosis; a third I propose to
treat of under the name of paralysis agitans. Though the
objections to its use are many, it possesses the advantages
of being already known, and of expressing two of the main
features of the disease to which it is applied.

The affection which Parkinson ^ described, and to which
he applied the name " shaking palsy," has since been very
carefully studied by many writers, and the facf has been
clearly made out that it is not a single disease.

Charcot, in numerous memoirs and lectures to which
reference has already been made, has very definitely shown
that the affection which he designates sclerose en ^plaques
disseminees — considered in this treatise under the name of
cerebro-spinal sclerosis — must be regarded as a distinct
morbid condition ; and in the first section of this work I
have made the same claim for multiple cerebral sclerosis.
The term paralysis agitans I apply to a very different affec-
tion from either, but one which I am confident will be
recognized as presenting well-defined characteristics. Or-
denstein " has included it with multiple cerebral sclerosis,

' Essay on the Shaking Palsy, London, ISIT.

^ Sur la Paralysie agitante et la Sclerose en plaques g6n6ralis6e, Paris, 1868.

PARALYSIS AGITANS.

707

and denies it any fixed seat ; but Jaccoud ' locates it in the
pons Yarolii, without, however, in my opinion, having any
good reason for so doing. Of all writers Dr. Handfield
J ones ' appears to have the clearest ideas of the affection
now under notice. Thus he says :

" It appears to me a question whether two distinct affec-
tions are not often comprehended under this name. For on
the one hand it appears pretty certain that there is one form
which is met with in old persons, is quite incurable, and
is associated with, if not dependent on, organic wasting
changes in the nervous centres; while another form occurs
in younger persons, is more curable, and therefore is pre-
sumably not dependent on organic change." It is this latter
disease which I propose to consider at present. The other
embraces cases of multiple cerebral sclerosis and cerebro-
spinal sclerosis.

Symptoms. — The primary manifestation is tremor, and
this, like the same symptom in the severer forms of disease
already considered, in which it forms an essential feature,
may begin in a very restricted or more extensive region of
the body. It is present whether voluntary movements are
performed or not with the afiected limbs, but is increased
by mental excitement of any kind, by physical exertion, or
by any cause capable of depressing the powers of the system.

It is not generally the case that the tremor shows any
tendency to advance much beyond its original limits, how-
ever small or extensive these may be. When it does exhibit
such a disposition, contiguous muscles are first attacked, and
then the corresponding ones on the opposite side of the body.

From the very first there is muscular weakness, not to
any very great extent, but still sufliciently evident to care-
ful examinations with the dynamometer. As the tremor
increases in violence or extent, the paralysis becomes more
obvious.

1 Op. cit., p. 424.

2 Studies on Functional Nervous Disorders, London, 1870, p. 382.

708

DISEASES OF NERVE-CELLS.

Sensibility is rarely affected, there is no bending of the
body forward, no festination, and no head-symptoms. The
tremor always ceases during sleep, except in very extreme
and long-continued cases, and there may be intermissions
of longer or shorter duration while the patient is awake.

Causes. — Paralysis agitans may result, from emotional
disturbance, from continuous or severe muscular exertion,
from some exhausting disease, such as dysentery, typhoid or
typhus fever, or rheumatism, or from blows, falls, or other
injuries. In many cases the cause cannot be ascertained.

Of twenty -one cases of which I have records, six were
apparently due to mental causes, four to excessive physical
exertion, four to diseases of various kinds, two to injuries,
and in five no cause could be discovered.

Two cases of mercurial trembling, the symptoms of
which affection are very similar to those of non-toxic paraly-
sis agitans, are not included among the foregoing.

Diagnosis.— From multiple cerebral sclerosis, paralysis
agitans is distinguished by the facts that there are no head-
symptoms, no festination, and no derangements of sensibility.
It is more apt to occur in persons under the age of fifty, and
may be met with in quite young persons. The reverse of
both these circumstances is true of multiple cerebral sclerosis.

From cerebro-spinal sclerosis, it is diagnosticated mainly
by the absence of any head-symptoms, by the fact that the
tremor usuaEy comes on before the paralysis, and is inde-
pendent of voluntary movements.

The character of the muscular action, and the history of
the case, will prevent its being confounded with chorea.

Prognosis. — Paralysis agitans rarely terminates fatally,
and when it does it is because the tremor has become so
general that death results from exhaustion. It, however,
often happens that all measures fail to relieve the agitation.
Of the twenty-one cases occumng in my own experience,
six were cured, four partially so, and in the rest no per-
manent effect was produced by any means I employed.

PARALYSIS AGITANS.

709

Morbid Anatomy and Pathology. — Nothing is known of the
morbid anatomy. In a few cases, patients have died eitlier
from the disease or from some intercurrent affection, and post-
mortem examinations have been made with negative results.
Petr£eus, quoted by Dr. Handfield Jones, relates two severe
cases, one of which proved fatal. At the autopsy nothing
was found but fatty degeneration of the heart and pneumonic
consolidation of the right lung. He remarks on the tremor
not being constant in many cases, ceasing for some days and
then returning with fresh force, or changing its seat from
one part to another.

In my opinion, the disease under consideration is due to
an irregular and diminished evolution of nerve-force froni
the motor nerve-cells in relation with the nerves supplying
the muscles in which the agitation exists. The pathology
of tremor, not the result of structural lesions, is a subject
which is beginning to be studied, but which is not yet clearly
understood. "We know that, when we have strongly exerted
an arm, for instance, the muscles are tremulous for some time
afterward, and that the agitation is rendered very evident
when we attempt to write or do any otner act requiring deli-
cate muscular adaptation. A period of rest must take place
before steadiness is regained. JSTow, in such a case the agita-
tion is not probably due to any cause inherent in the muscle,
but is the result of exhaustion in the nerve-cells and the dis-
engagement of insufficient force in an intermittent manner.
I suppose paralysis agitans to be due to some such action in
the motor nerve-cells in the gray matter of the spinal cord.

Treatment. — I have used electricity, both of the galvanic
and faradaic kinds, in all the cases of paralysis agitans that
have been under my charge, and in conjunction have
employed many internal medicines, such as arsenic, iron,
manganese, zinc, copper, phosphorus, strychnia, and seda-
tives of various kinds, including opium, bromide of potas-
sium, conium, stramonium, Indian hemp, and many others.
I am very decidedly of the opinion that the best treatment

DISEASES OF NERVE-CELLS.

consists in tlie use of the constant primary current to the
spinal cord, sympathetic nerve, and the affected muscles,
while at the same time strychnia and phosphorus, according
to the formula given on page 58, are administered internally.
By these means two of my six successful cases were en-
tirely cured within two months. One of these was sent to
me by my friend Dr. F. 'N. Otis. The affection was con-
fined to the right arm, and was probably due to inordinate
gymnastic exercise ; the other was a gentleman from St.
Louis, in whom the disease was also confined to the right
arm, and had apparently resulted from writing excessively.
Both had lasted several months.

The four other cases were, two of them, consequent on
other diseases, and two were without known cause. Three
were women ; the tremor in two was in both arms, and in
two, in one leg in each. The duration of the treatment was
from three to seven months. A full and nutritious diet, and
the avoidance of all mental excitement or strong physical
exertion, are important features in the treatment.

In the mercurial form of the disease the iodide of potas-
sium in large doses — twenty grains three times a day — must
be administered in conjunction with the other remedies.

WKirER's SPASM.

The disorder, which I think is best named writer's spasm,
has been variously designated, according to the prominence
which each author on the subject has given to some one
symptom. Thus it has been called scrivener's palsy, writer's
cramp, chorea scriptorum, mogigraphia, writer's dyskinesia,
etc.

By the majority, if not by all writers who have given it
a fixed seat, it is regarded as being a disease of the periph-
eric nerves. A consideration of its mode of orio-in and
symptoms must, I think, tend to show that it is an affection
of the motor nerve-cells, similar in several respects to paral-
ysis agitans.

PALALYSIS AGITANS.

711

AltLough in my nomenclature of the disease I have
termed it writer's spasm, I have done so simply for the sake
of convenience, and because the affection is more frequent-
ly met with among writers than other professional people.
It does, however, occur among those who are required by
any employment to perform delicate, complex, or uniform
actions with the fingers for many hours each day. It is thus
not uncommon among violinists, pianists, watch-makers,
jewellers, seamstresses, etc. The account I shall give of the
affection, though specially applicable to writers, will be rele-
vant to those of other professions who may suffer from this
singular disease.

Symptoms, — The first symptom usually observed is a feel-
ing of fatigue experienced in the muscles of the hand, fore-
arm, arm, and shoulder. The thumb is especially affected,
and is also often the seat of a dull, aching pain. Pains not
very severe nor fixed are also common in the muscles higher
up. This fatigue the patient endeavors to correct by grasp-
ing the pen, more firmly, and by making an increased men-
tal effort to regulate the muscular contractions. But he
only thereby adds to the difficulty, for the weariness and
pain are increased, the muscles become weakened, and,
moreover, irregular and incoordinate actions ensue, which
render the writing more or less unreadable.

If he perseveres day after day in his occupation he soon
reaches that stage of the disease in which the ability to
direct the pen in accordance with his will is lost, and the
automatic actions, which are of great importance in writing,
are likewise very much diminished. For a time, then, he
writes better when his mind is not occupied in directing the
formation of every letter, but in which he allows the muscles
as it were to take care of themselves. Constantly, however,
he feels the necessity of mental action, and this action inva-
riably increases the difficulty, until at last, the moment the
attempt is made to write, the pen, actuated by the muscles of
the fingers, executes such disorderly movements as to bear

712

DISEASES OF NERVE-CELLS.

no analogy with the words attempted to be written. A dis-
tinct paroxysm is thus induced, which lasts as long as the
patient persists in the attempt to write. When he discon-
tinues, the spasm ceases, and he can perform any other act
with the fingers without there being the slightest convulsive
movements. In some cases there is pain in the fingers, the
muscles between the metacarpal bones, and in those of the
forearm. The spasm is much worse if the patient be excited
or particularly anxious to do his best.

In the accompanying woodcut (Fig. 46) are represented
three attempts of a patient to write the name " James Ely."

Fig. 45.

At first some resemblance to the letter J is made, but in the
second trial it is less distinct, and in the third is lost alto-
gether.

I have witnessed eleven cases of this disease during the
past six years — all of them in writers except one, an interest-

WRITER'S SPASM.

713

ing case occurring in an engraver. This patient was seized
with the spasm in the fingers of the right hand whenever he
grasped his burin. He could write for hours perfectly well.

In three of the other cases the individuals had acquired
the power to write with the left hand, but the spasm soon
appeared in it on any attempt at writing.

All of my patients had resorted to various expedients to
obviate the spasms, under the idea that they were produced
by metallic pens carrying ofi" the electricity from the arm ;
several had, for a time, made use of quills, or hard rubber
pens, and for a time relief had been obtained, but the par-
oxysms soon became as bad as ever. Others had used very
thick pen-holders, and this expedient was also, for a time,
successful. In the end, however, all such efforts to prevent
the spasms proved futile.

In two cases there were other symptoms, indicative of
disorder of the central nervous system. These consisted of
headache, pain in the back, and occasional tremors in the
limbs.

Causes. — The disease is more apt to attack persons some-
what advanced in life, than the very young. All my pa-
tients were over forty years of age. All were males, though
this proclivity of men to the affection is not absolute, as
several cases are on record in which women, seamstresses
especially, have been its subjects. It is apparently some-
times induced by using the fingers in constrained positions.
In one of my cases, the patient, who had been in the habit
of writing with the hand supported by the little finger,
cured himself by allowing the whole hand to rest on the
desk. The principal cause — the habitual performance of
certain restricted mbvements — has already been sufficiently
considered.

Diagnosis.— Attention paid to the characteristic symp-
toms of writer's spasm will prevent its being mistaken for
lead-paralysis, progressive muscular atrophy, or any other
disease.

714 DISEASES OF NERVE-CELLS.

Prognosis. — In the early stage, writer's spasm admits of
cure. When it has existed a long time, and when the patient
cannot rest, a cure is almost impossible.

Of the eleven cases that have been under my care, seven
were incurable, having lasted several years, and resisting all
means of cure, even long rest. Of the other four, one was
in process of cure by his own expedient of changing the atti-
tude of the hand in writing, when he came under my obser-
vation. The remaining three cases were successfully treated
by means to be presently described.

Morbid Anatomy and Pathology. — As regards the morbid
anatomy, there are no data, and the lesion is probably not
one which can be detected by our present means of obser-
vation. The aifection is, however, doubtless due to disorder
in the normal action of the motor-cells, and this disorder is
the result of over-exertion of a particular set of muscles in a
particular way. Examples of cerebral exhaustion by the pre-
dominance of one idea, or a series of ideas for a long time,
are often witnessed. "Writer's spasm is, I conceive, the result
of a similar action on spinal motor cells.

Treatment. — The most indispensable means of cure is
rest, and, unless this can be secured, it is useless for the phy-
sician to undertake the treatment. In some cases it has
succeeded without any assistance. The abstinence from
writing should be absolute during at least six months.

The constant galvanic current has proved the most effect-
ual agent in my hands; I apply it to the sympathetic nerve,
the spinal cord in its upper part, and to all the muscles and
nerves of the upper extremity. A half an hour three times
a week, with a current of considerable intensity (forty cells),
will be sufficient. Faradization, in my experience, is more
productive of harm than benefit.

With the galvanism I have administered tliS combination
of phosphide of zinc, and extract of nux-vomica, recom-
mended on page 58 of this treatise.

When a cure cannot be effected, well-devised prothetic

LEAD PARALYSIS.

apparatus will enable tlie patient to write. Division of ten-
dons or muscles is not admissible.

LEAD PARALYSIS.

The frequency witli which lead paralysis is met with,
and the fact that the loss of power in certain muscles is gen-
erally unaccompanied by symptoms referable to the system
at large, must be my excuse for including it within the limits
of the present treatise.

Symptoms. — Before the occurrence of paralysis, the patient
has probably suffered from attacks of lead-colic, though this
is not invariably the case. The immediately precursory
symptoms connected with the loss of power are slight numb-
ness and tremors in the muscles of the upper extremities.
Occasionally, the muscles of the trunk and lower extremities
become involved in the trembling.

Ere long the patient observes that he has difficulty
in extending the fingers or wrist, and that there is a general
loss of strength in one or both hands. These symptoms go
on increasing in severity, and eventually he loses the power
to raise the hand or fingers. In extreme cases, the ability
to extend the forearm, or to raise the arm from the side, is
lost through the paralysis of the triceps and deltoid. Occa-
sionally, the extensors of the lower extremity are involved
in the paralysis.

The predominance of the loss of power in the extensors
has led to the idea that they alone are affected. The drop-
ping of the hand, the flexion of the forearm on the arm, the
hanging of the arm against the side of the body, and, when
the lower extremity is affected, the inability to raise the toes
so as to avoid striking them against the ground in walking^
all give countenance to this supposition. But careful ob-
servation shows that the difference is merely one of degree,
and that there is a very considerable loss of power in the
flexor muscles. Indeed, of many cases of the disease that I
have observed in hospital and private practice, I have never

716

DISEASES OF NERVE-CELLS.

seen one in wliich tlie flexors were not implicated with the
extensors.

Owing to the disuse of the muscles, atrophy takes place,
and this is frequently exceedingly well marked, and, from
the disturbance of the normal equilibrium between the sev-
eral groups of muscles, contractions and distortions ensue.
The circulation in the affected limbs becomes languid and
weak, and painful swellings result in consequence.

It is generally supposed that the right arm is more gen-
erally affected than the left ; such, however, does not appear
to be the case. Thus, Tanquerel des Planches,* of seventy-
nine cases in which the upper extremities were the seat of
the paralysis, found both affected in fifty-one, the left twenty-
three times, and the right twenty-four. Of thirty-two cases
of lead-paralysis occurring in my own practice, the upper
extremities were affected in all ; in twenty-seven both limbs
were the seat ; and, of the remaining five, three were in the
left, and two in the right. The left upper extremity was
therefore affected thirty times, and the right twenty-nine.

In some cases, the muscles of respiration become very
seriously paralyzed through the influence of lead, and death
then soon takes place. In two of my cases there was aphonia,
and in several the voice was materially weakened.

The electric sensibility and contractility are always
greatly reduced in all cases of lead paralysis. In the major-
ity of cases, no faradaic current, which it is safe to employ,
will produce contractions, and strong primary cm'rents are
necessary. The cutaneous sensibility is rarely impaired.

The saturnine cachexia is almost always present, and
the blue line on the gums can readily be distinguished.

Causes. — The fact that paralysis follows the introduction
of lead into the system admits of no doubt. This introduc-
tion may take place through the stomach, the air-passages,
or the skin. The two latter are the more common channels
for contamination.

' Traits des Maladies de Plomb. Paris, 1839, t. ii., p. 39.

LEAD PARALYSIS.

717

It is, of course, more frequently encountered among those
who work in lead^ such as lead founders and smelters, the
makers of white and red lead, painters, plumbers, printers,
etc. ; although it may occur among those who are only tem-
porarily or accidentally exposed to the toxic ipfluence. Thus,
it may be caused by drinking water which has passed through
lead pipes, or been kept in lead vessels, by using tobacco
which has been wrapped in lead foil, two cases of which
have happened in my experience,* and which is so common
a cause that, in France, Belgium, and Prussia, strong laws
have been passed against packing tobacco in lead ; by the
use of hair-dyes containing lead, of which I have seen three
cases ; the use of powders and enamels for the face, two
cases of which I have observed, one in consultation with my
friend Prof. Lewis A. Sayre ; and by several other less com-
mon causes. The majority of cases, however, occur in paint-
ers, probably for the reason that workers in white and red
lead, though more exposed, are aware of their danger, and
take effectual measures to prevent absorption.

Diagnosis. — The history of the case, including a knowledge
of the occupation of the patient, will generally prevent any
error in diagnosis. The presence of the peculiar cachexia,
the existence of the blue line around the gums, and the pre-
dominance of the paralysis in the extensors, especially those
of the wrist, will tend still further to render the diagnosis
accurate.

Prognosis. — The prospect of recovery depends altogether
on the ability to produce contractions in the paralyzed mus-
cles by electricity. If the induced current will effect them,
the cure will be rapid, if the interrupted primary current is
required, a longer time must elapse before success is attained ;
but, if the muscles will not react to either the induced or
primary currents, a favorable result is not to be expected.

' See my translation of Meyer's Electricity in its Relations to Practical Medi-
cine, New York, 1870, p. 181, for reference to other cases.

DISEASES OF NERVE-CELLS.

The extent of the atrophy is also an important element in
the prognosis.

Morbid Anatomy and Pathology. — So far as the central
nervous system is concerned, no spinal lesions have been
found unless in those cases complicated with cerebral symp-
toms, and when inflammation and softening have existed.
The difliculty is one which probably afiects the motor nerve-
cells of the spinal cord, and this in a way to be undiscov-
erable — as much so as the effects of opium, alcohol, hydro-
cyanic acid, strychnia, and other substances — by our present
means of investigation.

The muscles have been examined by Andral,' Gendrin,'
and Tanquerel des Planches,' and analogous results obtained.
The fibres have been found to be pale and yellowish, to be
friable, atrophied, and desiccated, I have repeatedly re-
moved small portions with Duchenne's trocar, and have al-
ways found the transverse striae disappearing, and fatty
degeneration making its aj)pearance.

The hypothesis, that the affection is, primarily, one of the
muscles, is not supported by facts. Such a thing as muscular
paralysis independent of nervous derangement somewhere
is unknown in the whole range of pathology. And those
cases of apparent loss of muscular irritability, resulting from
certain poisons, adduced by Longet, Bernard, Mitchell, my-
self, and others, were simply instances in which the loss of
nervous irritability took place from the periphery to the
centre. The present state of our neurological knowledge
is altogether against the idea of muscular irritability inde-
pendent of the nerves. When a muscle is no longer capable
of contracting, it is because the nerves are dead.

Facts, too, are against the notion that the lead acts by
contact with the muscles, and the circumstance of the pa-

' Clinique M6dicale, t. ii., p. 22*7.

^ Maladies de I'encephale, par Abercrombie, traduction, seconde Edition,
p. 576.

8 Op. cit., pp. 77, 144, 149.

LEAD PARALYSIS.

719

ralysis occurring so generally in the hands of painters, for
instance, is adduced in proof. But we have seen that the
left hand is just as frequently affected as the right, while it
is certainly less in contact with the lead. Moreover, those
cases of paralysis in the extensors of the hand, which have
resulted from hair-dyes and other cosmetics, are altogether
against the hypothesis in question.

Treatment. — The first thing to do in the treatment of a
case of lead-paralysis is to remove the lead from the system.
This is done by the administration of the iodide of potassium,
through the agency of which the mineral is converted into
a soluble compound, the iodide of lead, which is excreted
from the system, mainly by the kidneys. Some authors ad-
vise caution in the use of the iodide of potassium, on the
ground that the resulting compound is very poisonous, and
may produce highly-deleterious effects. In a great many
cases of lead-paralysis and other consequences of lead-poi-
. soning in which I have given the iodide, I have never seen
the least untoward result, and I always use it in large doses
from the beginning. In many cases the lead can be readily
detected in the urine. K there is great debility, or if the
cachexia be marked, iron, quinine, and strychnia, may be
employed with advantage.

But with all these measures the paralysis remains, and
would continue indefinitely, without the use of measures
directed specially against it : chief among these is electricity.
The induced current, if it will cause the muscles to contract,
is to be preferred. Each paralyzed muscle must be acted on
for two or three minutes every alternate day, so that for
both upper extremities the duration of a seance would vary
from a half to three quarters of an hour. In ordinary cases
two months will suffice to effect a cure.

But it often happens that the electric contractility of the
paralyzed muscles is so completely abolished that the induced
current is without effect. In such cases the primary inter-
rupted current must be used, and continued till, as will

720

DISEASES OF NERVE-CELLS.

eventually be the case, the induced current causes contrac-
tions. I have never seen a case in which the primary cur-
rent would not produce contractions. One of the worst
examples of the affection in question I ever saw is the
patient who formed the subject of a recent clinical lecture
to the class at the Belle vue Hospital Medical College.' His
improvement under the circumstances has been rapid, and
he is now (March 31st) able to earn his living again. In-
duced currents of great power failed to produce contractions,
and but for the use of the primary current he would have
been incurable.

If the primary current fails to act on the muscles, success
is out of the question.

In addition to electricity, frictions, kneading the muscles,
and passive exercise, are useful. Contractions may be over-
come by suitable prothetic apparatus. In a case under the
care of Prof. Sayre, and which I had the opportunity of see-
ing, the patient, a young lady, was able to play the piano
— though paralyzed in both hands — by means of an admira-
ble appliance devised by Dr. E. D. Hudson, of this city.

' JouENAL OF Psychological Medicine, January, 1811, p. 43.

SECTION V.
DISEASES OF PEEIPHEEAL I^EEYES.

I DO not propose to include under tliis Lead all the dis-
eases to wliich the peripheral nerves are liable, but to take
one or more as types of others which are different merely
from their, situation. Thus, any nerve of the body may be
paralyzed from injury or disease, or from some contiguous
affection capable of interfering with the due performance of
its functions. It would be useless to give such paralyses sep-
arate consideration, as their general features and the treat-
ment proper can be sufficiently pointed out under the head
of a typical representative.

Besides, many affections, which are often regarded as
located in the peripheral nervous system, are really central
in situation. Among them are various cases of paralysis,
spasm, hypersesthesia, and anaesthesia, which have already
been considered as symptoms of centric diseases.

I shall divide the affections of the peripheral nerves into
four groups: paralysis, spasm, anaesthesia, and hyperaes-
thesia.

CHAPTER I.

PERIPHERAL PARALYSIS.
FACIAL PARALYSIS.

Paealysis of the facial nerve has already been considered
as a symptom of several central lesions, but it may exist as
an affection of altogether peripheral origin. As such, it is
often known as Bell's para;lysis, on account of its real nature
having been first clearly pointed out by Sir Charles Bell.
The nerve in question, the facial or portio-dura of the sev-
enth pair, was, at one time, regarded as one of sensation,
and, in accordance with this view, was often divided for
neuralgia. The experiments of Bell and Magendie estab-
lished the fact of its being entirely a nerve of motion.

Symptoms. — The facial nerve is distributed to nearly
every muscle of the face. Its paralysis therefore causes such
decided change of expression as to be readily recognizable.
The most marked phenomenon, and one which is of impor-
tance in the diagnosis, is the inability to close the eye of the
affected side. This is due to the fact that the orbicularis
palpebrarum has lost its contractile power, while the leva-
tor palpebrae superioris, not supplied by the facial, but by
the third nerve, is not paralyzed, and keeps the upper lid
elevated. In consequence of this condition, the eye is con-
stantly exposed to the action of the atmosphere, and to con-
tact with extraneous substances. The patient cannot wink,
and thus the tears, not being distributed over the surface of
the eyeball or carried off by the nasal duct — the tensor tarsi

PERIPHERAL PARALYSIS.

723

also being paralyzed — run over the lower lid, and scald the
cheek. From this inability to wink, dust and other small
particles of matter are not removed, and hence considerable
irritation is produced. Exposure to strong light or to wind
adds to the inconvenience. Comparative comfort may be
obtained by the patient frequently closing the eye with the
finger, or by keeping the lids together with a piece of adhe-
sive plaster.

The next most prominent group of symptoms is due to
the loss of power in one lateral half of the orbicularis oris.
As a consequence, the patient cannot purse up the mouth on
that side, as in the act of whistling or spitting. From this
loss of tonicity the saliva is not retained on the affected side
of the mouth, but runs out over the lip, to the great annoy-
ance of the patient.

The muscles of mastication, the masseter, temporal, and
external and internal pterygoid, are supplied by the third
branch of the fifth pair of nerves, and- hence the ability to
chew is not impaired. The buccinator, the function of
which, in conjunction with the tongue, is to press the ali-
mentary bolus against the jaws, and thus keep it submitted
to their action, is supplied by the facial, and hence its office
is not performed. The food consequently accumulates be-
tween the jaws and the cheek, and it must be continually
removed by the finger.

The muscles which expand the face, as in the action of
laughing or smiling, are supplied by the facial, and their
paralysis destroys the normal equilibrium, and hence the
face is drawn toward the sound side. This loss of antago-
nism is most evident when the patient opens his mouth, and
particularly when he laughs or smiles, for the paralyzed
muscles, the zygomatici, and the risorius, are incapable of
responding to the emotion, while those on the sound side con-
tract vigorously.

The paralysis of the occipito-frontalis and of the corruga-
tor supercilii prevents the raising of the eyebrows, or frown-

724

DISEASES OF PERIPHERAL NERVES.

ing, and obliterates all wrinkles from tlie brow. As Kom-
berg remarks, there is no better cosmetic for elderly ladies
than facial paralysis (" Fiir alte franen kein wirksameres
cosmeticum existirt ").

Among other symptoms, it is noticed that the ala nasi is
depressed, and does not expand as air is drawn in through
the nostril, and that the articulation, especially of words
containing labials, is very indistinct.

The expression of one side of the face is therefore de-
stroyed ; it is a complete blank, incapable of responding to
any emotion, and unable to execute those motions which
in the normal condition are performed by its muscles.

Such are the obvious and superficial symptoms of an or-
dinary attack of unilateral facial paralysis. For the full
understanding of other important phenomena, a few words in
relation to the anatomy and physiology of the nerve are
necessary.

The facial nerve takes its origin from the posterior bor-
der of the pons Yarolii and the lateral tract of the medulla
oblongata. Some of its fibres of origin may be traced to the
floor of the fourth ventricle, and even to the lateral columns
of the spinal cord. A knowledge of its course and connec-
tions enables us to determine with a good deal of accuracy
the seat of the lesion by which it is paralyzed, and thus we
have an important element in making a prognosis.

From its point of apparent origin the facial passes for-
ward and outward, resting on the crus cerebelli, and leaves
the cranial cavity by entering the internal auditor}' meatus
with the auditory nerve. It next enters the aqueductus
Fallopii, and, passing through its whole length, makes its
exit from the skull by the stylo-mastoid foramen ; while in
the aqueductus Fallopii it gives off three branches, the two
superficial petrosal nerves, and the chorda tympani. The
great superficial petrosal passes to Meckel's ganglion, and
through this supplies the levator palati and the azygos
uvulae muscles ; the small superficial petrosal — regarded by

PERIPHERAL PARALYSIS.

Y25

some as a brancli of the glosso-pharyngeal, tliougli commu-
nicating with the facial — runs to the otic ganglion which
supplies the tensor-palati and tensor-tympani muscles, and
also, according to Bernard, presides over the secretion of the
parotid gland, through the auriculo-teraporal nerve ; the
chorda tympani goes to join the gustatory branch of the
fifth, and is in part distributed with this to the tongue, but
another portion of its fibres enters the submaxillary ganglion
which presides over the function of the submaxillary gland.

With this hrief resume of the anatomical and physiologi-
cal points of the facial nerve, we are prepared to study
other symptoms to which I have not as yet alluded ; for, in
the account given, I have simply considered the phenomena
of facial paralysis when the lesion is situated on the distal
side of the stylo-mastoid foramen. But the nerve may be
affected farther back, and, though in such a case we have the
symptoms already described, there are others which vary
according to the seat of the disease.

Thus, if the morbid process is in action above the origin
of the chorda tympani, but below that of the petrosal nerves,
the patient will experience a diminution but not a complete
abolition of the sense of taste upon the corresponding side
of the tongue. This fact led to the supposition that the
chorda tympani was a sensitive nerve, but the experiments
of Bernard and others have clearly shown that it is an effer-
ent nerve, convejaug influence from the brain, not to it. One
of its actions is to increase the flow of submaxillary saliva.
In addition, it supplies the lingualis muscle, and probably
erects the papillse of the tongue, and modifies the circulation
of this organ. When, therefore, a lesion of the facial exists
above the origin of the chorda tympani, the sense of
taste on that side is lessened because the dryness of the
mouth prevents the ready solution of the sapid substance.
The difficulty is augmented through the non-erection of the
papillee, and perhaps, also, by the change which has ensued
in the circulation. This diminution of the sense of taste

726

DISEASES OF PERIPHERAL NERVES.

therefore sliows that the lesion is seated on the central side
of the origin of the chorda tympani nerve.

Again, if the lesion be situated behind the gangliform
enlargement, from which the petrosal nerves arise, but an-
terior to the meatus internus, we have, of course, all the
symptoms mentioned, and in addition those due to paralysis
of the petrosal. One of them is the depression of the pala-
tine arch on the affected side ; it hangs lower than the oppo-
site one, and its edge is nearly straight instead of curved.
This condition results from paralysis of the levator-palati
muscle, which, as we have seen, is supplied by the great
petrosal through Meckel's ganglion. One of the two little
muscles of the uvula being powerless, the other draws the
uvula into a bow shape, with the concavity toward the
sound side. The uvula and the velum are also pulled
en masse toward the sound side by the action of the tensor
palati, the other being j)aralyzed through the implication
of the small petrosal nerve. The connection of the small
petrosal through the otic ganglion with the parotid gland
causes a diminution of the secretion of this gland when the
lesion of the facial is in the situation described.

Acuteness of hearing on the paralyzed side is sometimes
observed. This is accounted for by Landouzy,* on the ground
of the paralysis of the tensor-tympani muscle, which, as we
have seen, is supplied by the otic ganglion, but Brown-Se-
quard attributes it to hypersesthesia of the acoustic nerve
from vaso-motor spasm.

This last category of symptoms, therefore, indicates the
seat of the lesion to be at or behind the gangliform enlarge-
ment.

When the lesion is within the cranium, we have all the
symptoms mentioned, but they are complicated with others
indicative of derangements of other nerves, or of cerebral

' De I'Alteration de I'ouiie dans la Paralysie faciale, Gazette M^dicale,
Paris, 1851.

PERIPHERAL PARALYSIS.

727

disease. These Lave already been considered under other
heads.

In the foregoing account of facial paralysis, the unilateral
form, which is by far the most common, has alone been con-
sidered, but both nerves may be paralyzed, producing what
is called double facial paralysis, or facial diplegia. The con-
dition has been well described, among others, by Wachsmuth,*
and by Pierreson," the latter of whom has collected twenty-
eight cases as the basis of his memoir. Both sides may be
paralyzed simultaneously, in which instance the disease is
probably central, or one may follow the other. In either
case, the face presents a complete want of expression, and
the symptoms previously mentioned are duplicated in full.
Two excellent representations of the affection are given in
the report of a case by Mr. "Wright.' Only one case has
come under my observation. It was of long standing and
incurable. I lost sight of the patient before I could have
his photograph taken.

Causes. — Cold is a prominent cause of facial paralysis.
It is most apt to cause that form of the disease in which the
lesion is external to the temporal bone. Exposure to intense
cold, especially when the wind was blowing, has caused sev-
eral cases in my experience. The patient has gone to bed
feeling pretty well, and has awakened with one side of the
face paralyzed.

Rheumatic inflammation, occurring in the course of the
nerve, may also induce facial paralysis, as may likewise
tumors of the parotid gland, or other cause capable of making
pressure on the nerve. I have seen several cases which had
resulted from sleeping with the closed hand under the face ;
and it may occur in new-born children, as the result of

' TJeber progressive Bulbar-Paralyse und die Diplegia facialis. Dorpat,
1864.

i 2 De la Diplegie faciale. Archives Gen. de Medecine, Aout, ISCT, p. 139.

2 Notes of a Case of Double Facial Palsy, British Medical Journal, 1869,
p. 184.

728

DISEASES OF PERIPHERAL NERVES.

pressure bj the forceps. "Wounds and injuries of other kinds
may, of course, produce it.

Within the temporal bone, facial paralysis may result
from tumors from periostitis, from caries of the petrous
portion of the temporal bone, from disease of the middle ear,
from haemorrhage into the aqueductus Fallopii, and from
fractures of the temporal bone.

Within the cranium it may be caused by disease of the
pons Varolii, or of the medulla oblongata, by atrophy of the
nerve, by tumors, and as the consequence of injury.

Diagnosis. — Facial paralysis is distinguished from glosso-
labio-laryngeal paralysis, by the facts that in the latter the
symptoms aifect only the lower part of the face, and that
they are accompanied by paralysis of the tongue and of the
muscles of deglutition. From the facial paralysis of hemi-
plegia it is diagnosticated by the marked cii'cumstanee that,
in the latter disorder, the patient can close the eye, while in
the former it remains wide open. There are no other affec-
tions with which facial paralysis can be confounded, if the
slightest attention be given to its symptoms.

Prognosis. — The prognosis varies according to the seat
and the cause of the lesion, and the duration of the paraly-
sis. If this latter is due to cerebral or intra-cranial dif-
ficulty, or to disease existing within the aqueductus Fallo-
pii, the prospect of cure is remote. But, if the lesion exists
outside of the skull, and is capable of removal, or if the pa-
ralysis be the result of exposure to cold, or subjection to
pressure, and if the electric contractility of the muscles be
not destroyed, the case, under suitable treatment, will prob-
ably terminate favorably. By electric contractility, I do
not mean the ability to respond to the excitation of the in-
duced current, for this is lost at an early period in the
majority of cases, but to contract upon the application of
as strong a primary current as can with safety be applied
to the face.

In deep-seated lesions, if a clinical history of syphilis

PERIPHERAL PARALYSIS.

729

can be made out, the prognosis becomes more favor-
able.

If the affection has lasted a long time, and if contractions
of the paralyzed muscles from atrophy have taken place, the
probability of recovery is very slight, even if there is some
glimmering of electro-contractility.

Morbid Anatomy and Pathology. — When facial paralysis
results from cold, it may be from consequent neuritis, or
from inflammation excited in contiguous parts. In the
latter case lymph is effused and pressure is exerted upon the
nerve. Most of the other causes act by the pressure they
make on the nerve, and, though, as in the case of sleeping
with the fist under the face, the action may not be long
continued, the consequence is very lasting. The effects of
pressure upon the nerve are experienced when we sit too long
in one position, so as to compress the sciatic nerve, or when
persons go to sleep with one arm thrown over the back of
the chair on which they are sitting. The axillary plexus
is compressed, and paralysis, more or less complete, of the
muscles supplied by it, is the result. Several such cases
have come under my observation, and the resulting paraly-
sis is generally most difficult to remove.

Treatment. — The indications are : to remove the cause if
possible ; to put the nerve under the best possible conditions
for regaining its lost power ; and to preserve the organic
integrity and irritability of the muscles till this can take
place. When there is reason to suspect the existence of a
syphilitic taint, and the growth of exostoses of syphilitic
character in the aqueductus Fallopii, the iodide of potassium
with the bichloride of mercury should be given, according
to the formula on page 322. In two cases I succeeded in
effecting a cure by this treatment, conjoined with electricity,
when the latter by itself had produced no improyement.

For the restoration of the nerve function, we can do
little beyond securing healthy nutrition of the general sys-
tem, by the use of proper hygiene and tonics. Among the

730

DISEASES OF PERIPHERAL NERVES.

latter, strychnia is especially useful. I have never found
blisters or liniments to be of the slightest service.

The third indication is to be met by passive exercise,
such as can be produced by pinching and kneading the
muscles, and, above all, by the persistent use of electricity.
Without this latter agent facial paralysis cannot be cured.

If the induced current will cause the muscles to contract,
it should be employed. One pole is placed over the nerve
at its exit, from the stylo-mastoid foramen, and the mus-
cles of the paralyzed side are separately excited by the other.
A seance should last about fifteen minutes, and should be
repeated every alternate day, or every day in bad cases.

If the induced current will not cause contractions, the
primary interrupted current should be used for the purpose.
Care should be taken not to employ a current of too great a
degree of intensity, as serious consequences have resulted to
the vision by neglect of this precaution. As a rule, fifteen
Smee's cells will be sufficient ; but, if the current be passed
through a column of water before it reaches the face, a
larger number of cells may be used with safety. Means
must be taken to interrupt the current, as contractions are
only produced when the circuit is closed and opened.
When the primary current has been employed for a few
weeks, it will generally be found that the induced will
cause the muscles to contract, in which case it should be
substituted.

The first muscle to recover power is usually the orbicu-
laris palpebrarum, but several weeks, and sometimes months,
are requisite to bring about a complete cure.

Other peripheral paralyses, such as those occurring in
the muscles of the eye and its appendages, the muscles of
the larynx, the muscles supplied by the motor branch of
the fifth, the deltoid, etc., are to be treated upon the same
general principles as are applicable to facial paralysis, the
causes and pathology being very similar.

CHAPTER II.

PEBIPHERAL SPASM.

There are two affections which may be taken as the
types of peripheral spasm in .general : these are spasm of
the facial muscles— the mimic or histrionic spasm of Eom-
berg, the convulsive tic of the French— and torticolhs, or
the^spasm in the muscles of the neck supplied by the spinal
accessory nerve.

FACIAIi SPASM.

The spasms in the disease under notice may be either
clonic or tonic, the former being by far the more common.
In the clonic form, the muscles of the face, or a portion of
them, generally on one side, are suddenly and violently
contracted, and as suddenly relaxed. Sometimes, the angle
of the mouth is drawn back again, the upper lip, and the
alse of the nose are elevated ; and again, the spasm .affects
the orbicularis palpebrarum. In a case now under my
charge, occurring in a gentleman fromRahway, New Jersey,
both orbicularis muscles are affected with clonic and tonic
spasms, the eyes sometimes being closed for several minutes
at a time.

The spasms come on in paroxysms which are of variable
duration. I have seen them last continuously for over an
hour. Generally, they continue from a few seconds to one
or two minutes, and are repeated at intervals of about the
same time. They may generally be excited by emotional
disturbance of any kind ; by muscular exertion, by a current

732

DISEASES OF PERIPHERAL NERVES.

of wind, or other cause capable of exciting reflex actions.
In the case above referred to, they are always induced by
walking. They can be made to cease by pressure wpon the
facial nerve at various points, and they are generally arrested
by powerful mental occupation and by sleep.

In the tonic form of the affection the spasm persists, and
causes more or less distortion of the face. It interferes with
articulation, mastication, and especially with emotional ex-
pression.

The tendency is for either form to become habitual, and
hence to be difficult of cure.

Causes. — Cold is a common cause, as are also wounds and
injuries, and carious teeth. I have seen two cases recently,
from this last-named influence.

The Diagnosis calls for no special consideration, and the
Prognosis depends very much upon the duration. Generally,
it is unfavorable.

There are no facts bearing on the Morbid Anatomy, and
the Pathology is to be explained by the principle of reflex
excitation which, in this case, probably takes place through
the intermediation of the fifth pair. The analogy with
chorea is very great.

Treatment. — Of thirteen cases that have been under my
charge, five were cured. The means which I have found
most useful are, daily hypodermic injections of a mixture in
water of five drops of Fowler's solution, and the one-fiftieth of
a grain of atropia, and the daily use of the constant primary
current to the facial nerve and the convulsed muscles.

In several cases I have obtained good results from per-
manent pressure over the facial nerve. The gentleman pre-
viously referred to has had, at my suggestion, a steel spring
constructed which terminates in two pads, and which he
wears over the head in such a way as to compress the facial
nerves at their exit from the stylo-mastoid foramen. While
he wears it he has no spasms, but he is unable to endure the
pressure longer than a couple of hours.

PERIPHERAL SPASM.

733

Division of the affected muscles has been practised with
very moderate success.

TORTICOLLIS.

In this disease the spasms — which, as in the correspond-
ing affection of the face, may be either clonic or tonic —
occupy the sterno-cleido-mastoid, the trapezius, the rhom-
boids, and the levator anguli scapulae, separately or collec-
tively. The movements of the head in the clonic form
depend upon the seat of the spasms, the action being in the
direction of the tractile force of the affected muscles. Some-
times the contractions are very rapid, and again they are
slow and regular ; as in facial spasm, they are aggravated by
emotional excitement or physical exertion. They cease
during engrossing mental occupation, and during sleep.
Occasionally both sides are affected.

The reverse of facial spasm, the tonic form, is much the
more common, and it is to it that the term torticollis is
usually applied by surgical writers. The sterno-cleido-mas-
toid is generally its exclusive seat. The contraction is often
accompanied by pain.

Causes. — The etiology is not essentially different from
that of facial spasm.

Diagnosis. — There is no difficulty about the diagnosis of
the clonic variety. The tonic form is, however, liable to be
confounded with a similar affection so far as appearances
and consequences go, which is a veritable myositis, but which
is not an affection of the nervous system. The transitory
character of the latter affection and the severe pains are
sufficient diagnostic marks.

Prognosis. — The prospect of recovery from the clonic form
is very remote. Of seven cases that I have had under my
<^ charge, two only were cured.

Of the Morbid Anatomy, or of the Pathology, nothing is
known.

Treatment. — I have made use of every remedy, in the

734

DISEASES OF PERIPHERAL NERVES.

clonic form, which could in my opinion be of service. Iron,
belladonna, arsenic, morphia, chloral, chloroform, ether,
bromide of potassium, strychnia, zinc, and many other medi-
cines, have all failed. In one case I administered morphia
hypodermically in gradually-increasing doses, till at last two
grains were given twice a day, but without any permanent
effect. I have divided the muscles in four cases without
benefit. In one of them I cut both sterno-cleido-mastoids,
the left trapezius at its insertion into the occipital bone, the
left levator-anguli scapulae, and finally, with the concurrence
of my friend Prof. Markoe, the left complexus. But as soon
as one muscle was cut another became affected, and, after
the division of the complexus, the expectation of obtaining a
cure by myotomy was given up. The patient, a lady, from
the South, is still affected, though she appears to be getting
better gradually.

Electricity in any form has never cured a case in my
hands, though I have employed it steadily, for weeks at a
time, both as the primary and induced currents.

In the two successful cases, many means were tried with-
out success. In one, that of a young man from Newark, in
addition to other means, I divided the right sterno-cleido-
mastoid muscle twice, and it was afterward cut by my
friend Prof. Sayre. All the operations were unsuccessful,
although, as in the other cases, an apparatus was worn to
prevent the too rapid union of the muscle. This patient
was finally cured with large doses of the bromide of po-
tassium.

In the other case, that of a lady of this city, every means
used failed, till I tried the oxide of zinc ; she began with
doses of two grains three times a day, which were gradually
increased. When she reached fifteen grains at a dose, the
spasms ceased and did not return.

For the tonic variety, myotomy is the proper remedy, and
it is generally successful if a suitable apparatus be subse-
quently worn.

CHAPTER III.

PEBIPHEBAL ANESTHESIA.

Almost any part of the body may be deprived of sensa-
tion from causes acting on the peripheral nerves. One of
the most familiar examples of this fact is the anaesthesia pro-
duced in the foot and leg by pressure on the sciatic nerve in
the act of sitting too long in one position ; another is the loss
of sensibility produced in the hand and arm by pressure on
the ulnar nerve as it passes over the elbow.

Anaesthesia originating from cerebral, spinal, and cere-
bro-spinal causes, has already been considered, and the pres-
ent remarks will be strictly limited to the anaesthesia of
peripheral origin.

ANESTHESIA OF CUTANEOUS NERVES.

Symptoms. — The symptoms of anaesthesia from peripheral
causes do not vary materially from those which result from
central lesions. They consist of the various sensations of
numbness, such as tingling, " pins and needles," a feeling as
if ants are crawling over the skin, water trickling over it,
and, in complete cases, of absolute abolition of sensibility.
The conducting power of the nerve may be impaired in so
much as only to cause a retardation of the velocity of
excitations, and tlius an impression made on the terminal
extremities of a nerve is not felt for a much longer time
than would normally be the case. Peripheral anaesthesia
may be accompanied with disorders of nutrition from irregu-
larity of blood-supply. One form of the aflFection, of which
I have seen several examples, and which probably owes its

Y36

DISEASES OF PEKIPHERAL NERVES.

complication to vaso-motor spasm, is cliaracterized by un-
natural whiteness and shrinking of the skin, usually in the
hands. If an incision be made, little or no blood escapes.
In a young lady from Savannah, who was under my charge
a short time since, this condition existed to an extreme de-
gree, but disappeared with the removal of the anaesthesia.
Anaesthesia of peripheral origin in the cutaneous nerves is
often accompanied by more or less loss of power.

Causes. — Periphei'al cutaneous anaesthesia may be pro-
duced by a variety of causes. Among the chief are wounds
and injuries of various kinds, whereby the nerve is divided or
its conducting power impaired ; pressure such as that caused
by tumors, tight clothing, or accidental influences ; rheuma-
tism; exposure to intense cold ; the action of certain drugs,
such as aconite locally applied ; and diseases of the nerves.

Diagnosis. — The important point in the diagnosis of pe-
ripheral anaesthesia is the discrimination between it and
the anaesthesia, due to central causes. The elements of the
diagnosis have been dwelt upon at some length by Eombero;,
and perhaps needlessly so, for there can scarcely be a case
in which any difficulty in forming a correct opinion can
arise except in those cases of anaesthesia in which the flfth
pair is involved, and they will presently be more especially
considered. As regards the cutaneous nerves, the existence
of a peripheral cause, and the non-existence of evidences of
cerebral or spinal derangement, will be sufficient indications
of the nature of the affection. It could scarcely happen
that anaesthesia, the result of central lesions, could exist
without other marked symptoms being present, not con-
nected with cases of peripheral origin.

Prognosis. — This depends very much upon the cause
and the ability to remove it. In cases of simple division of
a nerve, union may be effected after a time, and the func-
tions restored, but if any considerable portion of the nerve
has been destroyed, the case is hopeless. Even when the
cause is removed, as may be accomplished for instance ir

TERIPHERAL ANESTHESIA.

737

cases due to pressure, a long period often elapses before
complete restoration takes place.

The Morbid Anatomy and Pathology call for no special
remarks after what has already been said.

Treatment. — The most important therapeutic measure
consists in the removal of tlie cause. Unless this can be
eflFected, it is useless to attempt other treatment. If this
can be accomplished, electricity is the most efficient agent
to be employed toward restoring the irritability to the
nerves. Sometimes the primary current is to be preferred,
at others the induced. In the latter case the wire brush
should be used as one of the electrodes, and the ansesthetic
parts be stroked with it at each seance.

ANESTHESIA OF THE FIFTH PAIR.

Symptoms. — These vary according to the seat of the
lesion. If the ophthalmic branch alone be implicated, the
ansesthesia is situated in the forehead, the upper eyelid, the
conjunctiva, and the lining membrane of the nostril. Irri-
tating substances, therefore, coming in contact with the eye
or the pituitary membrane, are not felt.

If the difficulty is limited to the superior maxillary branch,
the skin of the upper part of the face and the teeth of the
upper jaw are insensible. When the inferior maxillary branch
is atfected, the temporal region, the skin covering the upper
and lower jaw, the under lip, the chin, the lining membrane
of the mouth, the anterior third of the tongue, and the
teeth of the lower jaw, lose their sensibility ; mastication
becomes difficult, and the saliva flows from the mouth. In
either of these cases the seat of the lesion must be anterior
to the Gasserian ganglion. When all the branches of the
fifth are involved, and, as a consequence, anaesthesia exists
throughout the whole of one side of the face, it is very cer-
tain that the ganglion is affected, or that the main trunk
of the nerve is itself the seat of the disease. Anaesthesia
of the fifth nerve due to lesion of the Gasserian ganglion,
47

738

DISEASES or PERIPHERAL NERVES.

or of the main trunk, is very generally accompanied by
disorders of nutrition and derangement of the senses of
sight, smell, and taste. Fungoid growths on the gums and
defective circulation in the face are common in such cases ;
but ulceration of the cornea and congestion of the conjunc-
tiva do not occur unless the lesion is situated in the Gas-
serian ganglion, or anterior to it in the ophthalmic branch.

The Causes of peripheral anaesthesia of the fifth pair are
analogous to those which produce the corresponding affec-
tion in the cutaneous nerves ; but the Diagnosis requires a few
special remarks, and these may be stated in the form of
Romberg's propositions :

" a. The more the anaesthesia is confined to single fila-
ments of the trigeminus, the more peripheral the seat of the
cause will be found to be.

" h. If the loss of sensation affects a portion of the facial
surface, together with the corresponding facial cavity, the
disease may be assumed to involve the sensory fibres of the
fifth pair before they separate to be distributed to their re-
spective destinations ; in other words, a main division must
be affected before or after its passage through the cranium.

" c. When the entire sensory tract of the fifth nerve has
lost its power, and there are at the same time derangements
of the nutritive functions in the affected parts, the Gasseri-
an ganglion, or the nerve in its immediate vicinity, is the
seat of the disease.

" d. If the anaesthesia of the fifth nerve is complicated
with disturbed functions of adjoining cerebral nerves it may
be assumed that the cause is seated at the base of the brain."

The Prognosis, the Morbid Anatomy, the Pathology, and
the Treatment, call for no remarks additional to those made
when peripheral cutaneous anaesthesia was under considera-
tion, except that, as regards the treatment, if the primary
current is employed, care should be taken that the tension
be not too high, a point to which reference has already fre-
quently been made.

CHAPTEK lY.

PERIPHERAL HYPERESTHESIA {NEURALGIA).

Under this head I propose to consider the principal
painful affections embraced under the term neuralgia. No
designation in medical nomenclature has been more abused
than this. Any pains, the origin of which cannot readily
be ascertained, and many which are well known to depend
upon central lesions, are called neuralgic. I propose, in the
present remarks, to include under it those affections only
which, so far as can be ascertained, are not due to disease
either of the brain or spinal cord, but the seat of which is
in the nerves themselves. Following the classification of
Valleix, I shall consider —

a. ISTeuralgia of the fifth pair.

5. Cervico-occipital neuralgia.

c. Cervico-brachial neuralgia.

d. Dorso-intercostal neuralgia.

e. Lumbo-abdominal neuralgia.

f. Crural neuralgia.

g. Sciatic neuralgia.

NETJEALGIA OF THE FIFTH PAIR OF NERVES.

Symptoms. — Either division of the fifth pair of nerves
may be the seat of the disease, or all may be simultaneously
affected.

1. OjpMhalmiG Division. — This branch of the fifth is dis-
tributed to the side of the nose, the eyelids, the lachrymal
gland, the globe of the eye, the conjunctiva, the forehead,

DISEASES OF PERIPHERAL NERVES.

and the scalp. The long root of the ciliary ganglion com-
municates with the nerve, and anastomoses take place with
the superior maxillary branch.

Yalleix has shown that there are particular spots in
which neuralgic pains are always more severe than in others,
and that these are the points where the nerve either passes
through a foramen in a bone, or penetrates a fascia. In the
ophthalmic nerve several of these points are to be found.
The most prominent is in the nerve as it passes out of the
supra-orbital foramen to ramify on the forehead and scalp ;
another is seated in the upper eyelid ; another in the long
nasal branch as it passes to the skin through the line of
union of the nasal bone with the cartilage ; another is
located in the eyeball, and another at the inner angle of the
orbit. Besides these which are peculiar to the ophthalmic
branch, there is another situated near the parietal emi-
nence, and which corresponds to the inosculation of various
branches.

The most common form of neuralgia affecting the oph-
thalmic division of the fifth nerve is hemicrania. The
occurrence of the paroxysms is marked by a tendency to
periodicity. The pain is exceedingly sharp and lancinating,
and occupies the frontal, temporal, or parietal regions, being
especially intense at the point corresponding to the supra-
orbital foramen, or at that situated near the parietal emi-
nence. It frequently happens that this latter spot is the
only part affected. The paroxysm usually comes on in the
morning, and rarely lasts longer than twenty-four hours ;
frequently it disappears at nightfall. The pain is greatly
aggravated by mental or physical exertion, by loud noises
or bright lights. It is often complicated with nausea and
vomiting, in which case it constitutes what is known as
sick-headache. In other cases the pain is mainly confined
to the eyeball and the accessory parts. There is then lach-
rymation, from the fact that the lachrymal gland is sup-
plied from the ophthalmic division, and there may be visual

PERIPHERAL HYPERESTHESIA (NEURALGIA) 741

troubles from the relation which the nerve bears to the
ciliary ganglion.

This form may also be distinctly periodical in its occur-
rence, and it rarely lasts longer at one time than twenty-
four hours.

2. Superior Maxillary Division. — The distribution of
this branch is to the teeth of the upper jaw, the lower eye-
lid, the side of the nose, the upper lip, to the lining mem-
brane of the nose and mouth, and to the temple and cheek.
It inosculates freely with the ophthalmic division, and is in
intimate relations with the spheno-palatine ganglion.

The painful points of Yalleix for this nerve are, in the
infra-orbital nerve as it emerges from the infra-orbital fora-
men to be distributed to the lower eyelid, the side of the
nose, and the upper lip ; over the most prominent part of
the malar bone, where the nerve is very superficial ; an un-
certain point on the gums of the upper jaw ; a similar point
on the upper lip, and another on the palate, Neuralgia of
this division occurs in paroxysms, and may, like that of the
ophthalmic, be periodical in its attacks.

3. Inferior Maxillary Dimsion. — This nerve is distrib-
uted to the cheek, the tongue, the lower jaw and teeth, and
to the sub-maxillary gland. It is also in connection with
the otic and sub-maxillary ganglia.

Its painful points are a spot on the auriculo-temporal
branch, just in front of the ear; another on the inferior
dental nerve, where it emerges from the inferior dental
canal, through the mental foramen.

It is generally the case that facial neuralgia is limited to
one side, but both are sometimes affected. It may also be
confined to very restricted boundaries, the extreme terminal
branches alone being involved.

Causes. — According to my experience, facial neuralgia is
rarely met with in young persons, but is more common
during adult life. It is certainly more apt to attack females
than males, and is often transmitted by hereditary influence.

742

DISEASES OF PERIPHERAL NERVES.

The most common exciting cause is, in this country,
malaria, and this is especially the case with the affection in
the ophthalmic division, as manifested in hemicrania and
supra-orbital neuralgia. This latter is often popularly
known as " brow-ague."

Among other causes are to be mentioned mental excite-
ment, anxiety, intense intellectual exertion, exposure to cold
and damp, the loss of blood, as in the case of women after
child-birth, or from menorrhagia, prolonged lactation, and
the changes due to the cessation of the menses.

Another very common cause is syphilis, and there is
reason to think that the gouty diathesis may also excite it.

But, as Anstie ' remarks, it is after the powers of life
begin to decline that the most formidable varieties of facial
neuralgia are encountered. Those forms which are attend-
ed with muscular spasm, constituting the " tic douloureux "
of the French, and another still more violent which Trous-
seau has designated " tic epileptiform," are almost peculiar
to advanced life. The pain in these affections is atrocious,
and is excited by the least muscular action in the face, by a
touch, however light, or even by a breath of air. They are
often accompanied by an hereditary tendency to insanity,
and they eventually wear away the life of the miserable
sufferer.

Facial neuralgia may also result from tumors compress-
ing the nerves, from thickening of tlie bones, or of the
peiosteum, causing narrowing of the foramina through
which they pass, and from interstitial organic changes
taking place in the nerve-trunks.

The Diagnosis requires no special remarks, and the
Prognosis depends upon the cause, and the ability to re-
move it. In general terms it may be stated that the mala-
rial and syphilitic forms are usually readily cured, while
others are seldom thoroughly relieved. The intense varie-
ties, coming on for the first time late in life, are absolutely

» Article Neuralgia, in Reynolds's System of Medicine, vol. ii., p. '726.

PERIPHERAL HYPERESTHESIA (NEURALGIA). 743

incurable, and are very seldom capable of even being miti-
gated.

CEKVICO-OCCIPITAL NEURALGIA.

In this affection the pain is situated in the sensory
branches of the first four cervical nerves, though the great
occipital which arises from the second cervical is mainly
the one affected. These nerves are distributed to the occi-
pital and posterior parietal regions, as well as to the neck
and lower part of the cheek. The painful points are those
at which the nerves become most superficial.

The pain in cervico-occipital neuralgia, though severe,
is not in general so intense as that of the facial variety.
There is a tendency in the affection to extend so as to in-
volve the inferior maxillary nerve, and, when the disease
has lasted some time, a paroxysm rarely occurs without this
nerve being implicated. After the acute stage of a paroxysm
has passed off, there remains a dull, heavy pain, which con-
tinues several days, and which is increased by the pressure
of the clothing, by mental exertion, or by moving the head.

The Causes are similar in general character to those of
facial neuralgia, though cold is probably a still more power-
ful factor in the etiology.

The Diagnosis and Prognosis call for no special remarks.

CERVICO-BBACHIAL NEURALGIA.

In this form the brachial plexus, the nerves which go to
form it — the five lower cervical and first dorsal — and those
which arise from it, are the seat of the affection. The pain
may therefore be felt in the subclavicular region, along the
whole length of the upper extremity, or in the situation of
the mammary gland. The exact seat varies of course with
the particular nerve affected. It is often accompanied by
various sensations of numbness, and interferes more or less
with the movements of the limb. The principal painful
points are the axillary in the arm-pit, and corresponding to

744

DISEASES OF PERIPHERAL NERVES.

the brachial plexus, the scapular near the inferior angle of
the scapula, the acromial in the angle between this process
and the clavicle, the median cei^halic in the bend of the
elbow, the ulnar corresponding to the most superficial por-
tion of the ulnar nerve at the back of the elbow-joint, and
the radial at the point where the radial nerve becomes su-
perficial at the lower part of the forearm.

Among the Causes of cervico-brachial neuralgia, excessive
muscular exertion and injuries are preeminent. It is not
so frequently the result of malaria as the corresponding
affection of the facial nerve.

There is nothing special to be said relative to the
Diagnosis and Prognosis.

DOESO-INTEECOSTAIi NEURALGIA.

In this affection the dorsal and intercostal nerves are
the seat of the pain. In the first case the disease is often
regarded as rheumatic or muscular, and has received the
popular name of lumbago ; in the latter it is often known
as pleurodynia, "Whether in the dorsal or intercostal form,
the pain does not often occur in well-marked parox^^sms,
but is more or less continuous in character, and is much
increased by muscular exertion. In the dorsal form, the
mere act of straightening the back causes great suffering,
and in the intercostal respiration is exceedingly painful.

The painful points are very numerous, and in general
correspond to the situations where the nerves become most
superficial. .

The association of intercostal neuralgia with herpes zoster
of unilateral form is an interesting fact, and one which has
led to the recognition of other skin-diseases as being essen-
tially nervous affections.

The Causes of dorso-intercostal neuralgia are cold, ex-
haustion, and, in women, the depression of vital power,
due to profuse menstruation or prolonged lactation. Anse-

PERIPHERAL HYPERESTHESIA (NEURALGIA). 745

mia, both in males and females, is also a common cause,
however produced.

The Diagnosis of the dorsal form is not a matter of dif-
ficulty ; the intercostal has, however, often been mistaken for
pleurisy. The Prognosis is more favorable than in the other
neuralgias described.

Lumho-ahdominal and crural neuralgias are not very
common. The latter is seldom a primary affection.

SCIATIC NEURALGIA.

This form is characterized by the occurrence of pain in
the course of the sciatic nerve and its branches, mainly in
those distributed to the skin. It may be restricted to the
gluteal region and upper part of the thigh, or may extend
to the sole of the foot or toes. The principal painful points
are those which correspond to the sacral foramina, where
the large and small sciatic nerves emerge from the pelvis ;
a series corresponding to the emergence of cutaneous branch-
es through the fascia, a fibular point at the head of the fibula,
an external malleolar, and an internal malleolar.

Sciatica generally begins as a dull, heavy ache, which
gradually becomes more and more intense, and which, like
all the other forms of neuralgia, is aggravated by muscular
exertion. It is subject to exacerbations of violence, during
which the least agitation of the body still further increases
the intensity of the suffering. Sometimes the pain darts
through the nerves like electric shocks, while at others it re-
tains its original situation. It is often accompanied by mus-
cular contractions. Anaesthesia is generally present in the
parts which are or have been the seats of the pain, and can
readily be detected with the sesthesiometer.

The affection generally lasts two or three months, and is
liable to recur.

Causes. — The etiology of sciatica is not materially dif-
freent from that of other neuralgias, except so far as it is

746

DISEASES OF PERIPHERAL NERVES.

modified by local circumstances. Among these latter, are
enlargement of tlie prostate gland, by which pressure is
exerted on the nerve, various tumors of the abdominal
organs, the pressure of the foetal head in child-birth, accu-
mulations of faeces in the large intestine, etc. It is also
occasionally induced by the pressure on the nerve which
results from sitting long on a hard chair. Several cases of
this kind have come under my observation.

The Diagnosis is not a matter of any difiiculty, though I
have many times seen cases mistaken for diseases of the
spinal cord, and vice versa. The Prognosis depends greatly
on the ability to remove the cause.

Morbid Anatomy and Pathology. — The remarks which might
be made under this head have already been expressed to
some extent in the foregoing pages, and there is not much
more that could be said without entering the domain of pure
speculation. I may, however, state my opinion that neural-
gia, not directly the result of some physical cause interfering
with the integrity of the nerve in which it is situated, is
almost invariably induced by a depressed state of the system.
Its existence in such cases is evidence, therefore, of deficient
physical stamina, and of the fact that the nervous system is
not duly nourished. The remote factor may be malaria,
syphilis, rheumatism, gout, or some other cause capable of
lowering the vitality of the organism, and, as a consequence,
that of the nerves. It is of course of the utmost importance,
with reference to the treatment, to ascertain whether there
is, or is not, any such constitutional taint, but, whatever the
result of our inquiries in this direction, that system of thera-
peutics is best which, in addition to physical measures, em-
braces restorative means.

Treatment. — The measures which it is proper to employ
in neuralgia may be divided into two categories, the consti-
tutional and the local.

Among the constitutional remedies must be included

PERIPHERAL HYPERESTHESIA (NEURALGIA). 747

those which are for the correction of any taint which may
be present. If there is reason to suspect the existence of
syphilis, iodide of potassium is an indispensable remedy, and
should be given in large doses. If malaria can be ascer-
tained to have exerted an influence, quinine must be admin-
istered ; and, indeed, it is safe to act upon the theory that
this has been the cause, unless some other can be clearly
made out. It must be recollected that malaria may give
rise to neuralgia, especially in the facial nerve, without there
having been any other manifestation of its toxic effect ; and
that the affection is often cured by large doses of quinine,
when the patient has not apparently been subjected to the
malarious influence. Should there be no relief after three
or four ten-grain doses of quinine, it should still not be de-
cided that the disease is not of malarious origin, but arsenic
should be administered. I have seen many cases of supra-
orbital neuralgia, undoubtedly the result of miasmatic poi-
soning, effectually cured by arsenic, when quinine had failed.
From my own experience, I am very well convinced that it
acts much more efficaciously when administered by hypoder-
mic injection than by the stomach. Four drops of Fowler's
solution, diluted with an equal quantity of water, should be
given twice a day, and the quantity should be gradually
increased to eight or ten drops at a dose.

If a gouty diathesis is present, colchicum should be used ;
and, if rheumatism be clearly made out, the blood should at
once be rendered alkaline by liquor potassse.

Whether any specific difficulty be discovered or not, gen-
eral tonics are always indicated ; among them cod-liver oil
occupies the front rank, and iron is not far behind it in
value ; strychnia is also very generally useful. Among con-
stitutional remedies, ergot has proved of very decided benefit
in my hands, and this especially in sciatica. It should be
given in large doses, a drachm or more of the tincture three
times a day.

A full and nutritious diet is of great value in the treat-

748 DISEASES OF PERIPHERAL NERVES.

ment of neuralgia, as are likewise sunliglit, and pure and
fresli air.

In addition to these purely constitutional measures,
there are others which, though administered to act upon
the system at large, are given for the purpose of arrest-
ing a paroxysm, or deadening sensibility, so as to prevent
the pain being felt. The medicines embraced in this cate-
gory are included among the stimulants, narcotics, and
anaesthetics. Opium and its various preparations are preemi-
nent as palliatives of the neuralgic paroxysm, and morphia
stands first among them. It is most efficaciously adminis-
tered hypodermically, in doses varying from one-eighth grain
to half a grain, or even more in extreme cases. Great care
should be exercised in its use, and the smaller quantity men-
tioned should not be exceeded except by regular gradations.
It is immaterial in what part of the body the injection is
made, so far as its influence over the pain is concerned.

Among other medicines of this class are belladonna, or
its alkaloid atropia, Indian hemp, aconite, bromide of potas-
sium, hydrate of chloral, hyoscyamus, conium, and some
others of minor importance.

Of very great value are chloroform and ether, adminis-
tered by inhalation, and the various forms of alcoholic
liquors.

The chief local means of treatment in neuralgia are
counter-irritation — preferably in the form of repeated blis-
ters, which should be applied over the course of the painful
nerves, and which are especially valuable in sciatica — and
the local application of tincture of aconite, and of veratria in
the form of an ointment, or an alcoholic or ethereal solution.

But, above all local means, not only for relieving the pain
of any particular paroxysm, but also for efiecting a perma-
nent cure, electricity stands first. I have employed it in
every possible form, and am satisfied that the primary gal-
vanic current is the preferable agent. Indeed, I verv much
doubt if the induced current, unless in a few cases, when

PERIPHERAL HYPEBiESTHESIA (NEURALGIA). 749

the wire-brush lias been employed, has ever, in my experi-
ence, accomplished any very decided benefit. In the
employment of the primary current, the positive pole
should be applied over the seat of the pain, and not more
than fifteen or twenty Smee's cells should be used. The ap-
plication should be continuous for at least half an hour, and
should be repeated every day for several weeks, and in ex-
treme cases longer. I have cured a number of severe cases
of nearly every kind of neuralgia by the aid of electricity
when other means had entirely failed. I rarely, however,
employ it without at the same time insisting on such con-
stitutional treatment as the case seems to require.

I have several times used acupuncture with success, and
have likewise employed electro-puncture with decided bene-
fit in ten cases of sciatica. In either operation the needles
should be introduced at the most painful parts, and, when
galvanism is also used, the current should be passed continu-
ously through the needles. In a notable case of sciatica
which I saw in consultation with my friend Dr. John Gal-
laher, of this city, a severe attack of sciatica was at once cut
short by electro-puncture. Two or three cells will afibrd a
current of suflScient tension.

As to surgical operations on the affected nerves, either of
section or excision of a portion of their continuity, the suc-
cess which has hitherto followed them has not been such as,
in my opinion, to warrant their repetition.

I^DEX.

Abscess, chronic cerebral, 254.
Active cerebral congestion, 33.

symptoms, 34.

apoplectic form of, 37.

epileptic form of^ 39.

maniacal form of,

first stage of, 34.

second stage of, 37.

third stage of, 41.
Acute cerebral meningitis, 219.
Acute myelitis, 456.

symptoms, 456.

causes, 459.

diagnosis, 459.

prognosis, 460.

morbid anatomy, 460.

pathology, 460.

treatment, 460.
Acute spinal meningitis, 444.
Affective insanity, 336.
Anaemia, cerebral, 61.
Au£Emia of antero-lateral columns of
cord, 430.

symptoms, 432.

causes, 432.

diagnosis, 433.

prognosis, 433.

morbid anatomy, 434.

pathology, 434.

treatment, 437.
Anaemia, spinal, 396.

of posterior columns of spinal cord,
397.

Anaesthesia of cutaneous nerves, 735.

symptoms, 735.

causes, 736.

diagnosis, 736.

prognosis, 736.
Anaesthesia of the fifth pair, 737.

symptoms, 737.

causes, 738.

diagnosis, 738.

prognosis, 738.

morbid anatomy, 738.

pathology, 738.

treatment, 738.
Anaesthesia, peripheral, 735.

Antero-lateral columns of cord, ans-
mia of, 430.

sclerosis of, 471.
Aphasia, 166.
Athetosis, 654.

cases of, 654.

description of, 654.
Atrophy and disappearance of motor
nerve-cells, 677.

of motor and trophic nerve-cells,689.

of trophic nerve-cells, 663.

Brain, tumors of, 301.

Catalepsy, 590.

symptoms, 590.

causes, 594.

diagnosis, 594.

prognosis, 595.

morbid anatomy, 595.

pathology, 595.

treatment, 596.
Cerebral abscess, chronic, 254.
Cerebral anaemia, 61.

symptoms, 61.

causes, 64.

diagnosis, 66.

prognosis, 67.

morbid anatomy, 67.

pathology, 67.

treatment, 69.
Cerebral arteries, obliteration of, 119.
Cerebral congestion, 33.

causes, 43.

diagnosis, 46.

prognosis, 49.

morbid anatomy, 50.

pathology, 52.

treatment, 54.
Cerebral haemorrhage, 74.

symptoms, 74.

causes, 85.

diagnosis, 90.

prognosis, 95.

morbid anatomy, 97.

pathology, 99.

treatment, 106.

INDEX.

Cerebral meningitis, acute, 219.

symptoms, 219.

causes, 224.

diagnosis, 225.

prognosis, 225.

morbid anatomy, 226.

pathology, 227.

treatment, 228.
Cerebral meningitis, chronic, 231.

tubercular, 234.
Cerebral rheumatism, 223.
Cerebral sclerosis, diffused, 260.

multiple, 278.
Cerebral softening, 137.

symptoms, 137.

causes, 145.

diagnosis, 147.

prognosis, 148.

morbid anatomy, 149.

pathology, 151.'

treatment, 157.
Cerebritis, 246.
Cerebro-spinal diseases, 545.
Cerebro - spinal sclerosis, multiple,
637.

Cervico-brachial neuralgia, 743.

causes, 744.

diagnosis, 744.

I)rognosiSj 744.
Cervico-occipital neuralgia, 743.

causes, 743.

diagnosis, 743.

prognosis, 743.
Chronic cerebral abscess, 254.
Chronic cerebral meningitis, 231.

symptoms, 231.

causes, 232.

diagnosis, 232.

prognosis, 232.

morbid anatomy, 232.

pathology, 232.

treatment, 232.
Chronic spinal meningitis, 445.
Chorea, 600.

symptoms, 601.

causes, 609.

diagnosis, 610.

prognosis, 611.

morbid anatomy, 612.

pathology, 612.

treatment, 615.
Classification of insanity, 335.
Congestion, cerebral, 33.

spinal, 385.
Cretinism, 338.
Crural neuralgia, 745.
Cutaneous nerves, anaesthesia of, 735.

Definition of insanity, 332.
Degeneration, secondary, of spinal

cord, 523.
Delirium, 343.
Delusion, 341.

Dementia, 336, 338, 373, 374.

Dementia, organic, 337.

senile, 337.
Diffused cerebral sclerosis, 260.

symptoms, 260.

causes, 272.

diagnosis, 273.

prognosis, 273.

moroid anatomy, 274.

pathology, 275.

treatment, 275.
Diseases of nerve-cells, 663.

of peripheral nerves, 721.

of the spinal cord, 385.
Dura mater, hsematoma of, 116.

Eccentricity, 331.
Ecstasy, 597.

symptoms, 597.

causes, 598.

diagnosis, 598.

prognosis, 598.

morbid anatomy, 598.

pathology, 598.

treatment, 598.
Embolism, 127.

symptoms, 127.

causes, 131.

diagnosis, 132.

prognosis, 134.

morbid anatomy, 134.

pathology, 134.

treatment, 136.
Emotions, 328.
Emotional insanity, 338, 351.
Encephalitis, 246.
Epilepsy, 560.

symptoms, 560.

paroxysm, varieties of, 563.

causes, 572.

diagnosis, 575.

prognosis, 576.

morbid anatomy, 577.

pathology, 578.

treatment, 582.
Epileptic insanity, 337.

Facial neuralgia, 739.
Facial paralysis, 722.

symptoms, 722.

causes, 727.

diagnosis, 728.

prognosis, 728.

morbid anatomy, 729.

pathology, 729.

treatment, 729.
Facial spasm, 731.

symptoms, 731.

causes, 732.

diagnosis, 732.

prognosis, 732.

morbid anatomy, 732.

pathology, 732.

treatment, 732.

752

INDEX.

Fifth pair, anjestliesia of, 737.

hyperiBstliesia of, 739.

neuralgia of, 739.
Functional derangements of motor
nerve-cells, 706.

General paralysis, 338j 366.
General principles of msanity, 324.
Gliomata, 320.

Glosso-labio-laryngeal paralysis, 677.
symptoms, 678.
causes, 684.
diagnosis, 685.
prognosis, 686.
morbid anatomy, 686.
pathology, 687.
treatment, 688.

Haemon-hage, meningeal, 115.
Haemorrhage, spinal meningeal, 440.
Hsemorhage, spinal, 440.

symptoms, 440.

causes, 441.

diagnosis, 441.

prognosis, 441.

morbid anatomy, 442.

pathology, 442."

treatment, 442.
Haematoma of the dura mater, 116.

causes, 117.

prognosis, 117.

diagnosis, 117.

morbid anatomy, 118.

pathology, 118.

treatment, 118.
nallucinatiou, 340.
Hydrophobia, 545.

symptoms, 545.

causes, 551.

diagnosis, 553.

prognosis, 554.

morbid anatomy, 556.

pathology, 556.

treatment, 557.
Hyperassthesia peripheral, 739.
Hypertrophy of muscular connective
tissue, 099.

symptoms, 700.

causes, 701.

diagnosis, 703.

prognosis, 703.

morbid anatomy, 703.

pathology, 704.

treatment, 705.
Hysteria, 619.

symptoms, 619.

causes, 629.

diagnosis, 631.

morbid anatomy, 632.

pathology, 632.

treatment, 634.

Idiocy, 336, 338, 373.

Illusion. 339.
Imbecihty, 336.
Incoherence, 342.
Infantile paralysis, 689.
Inhibitory paralysis, 431.
Insanity, 324.

classification of, 335.

causes, 376.

diagnosis, 377.

prognosis, 377.

morbid anatomy, 378.

pathology, 378.

treatment, 380.

definition of, 332.

affective, 336.

emotional, 338, 351.

epileptic, 337.

intellectual, 338, 345.

perceptional, 338, 343.

paralytic, 337.

simple, 337.

volitional, 338, 357.
Intellect, 328.

Lead paralysis, 715.

symptoms, 715.

causes, 716.

diagnosis, 717.

prognosis, 717.

morbid anatomy, 718.

pathology, 718.

treatment, 719.
Locomotor ataxia, 484.
Lumbo-abdominal neuralgia, 745.

Mania, 336, 338, 358.
Melancholia, 336.
Meningeal hsmorrhage, 114.

causes, 115.

prognosis, 116.

diagnosis, 116.

morbid anatomy, 116.

pathology, 116.

treatment, 116.
Meningitis, cerebral, chronic, 231.

cerebral, acute, 219.

cerebral, tubercular, 234.

spinal, 444.

senile, 223.
Monomania, 336.

Motor nerve-cells, atrophy and disap-
pearance of, 677. '
Motor nerve-cells, functional derange-
ments of, 706.
Motor and trophic nerve-cells, atrophy

and disappearance of, 689.
Multiple cerebral sclerosis, 278.
symptoms, 269.
causes, 288.
diagnosis, 289.
prognosis, 290.
morbid anatomy, 290.
pathology, 291.

INDEX.

753

Multiple ccrebro-spinal sclerosis, 637.

symptoms, 637.

causes, 651.

diagaosis, 651.

prognosis, 653.

morbid anatomy, 652.

pathology, 652.

treatment, 652.
Muscular connective tissue, hypertro-
phy of, 699.
Myelitis, acute, 456.

Nerve-cells, diseases of, 663.
Nerve-cells, motor, functional derange-
ments of, 706.
Nerves, cutaneous, anaesthesia of, 735.
Neuralgia, 739.

varieties of, 739.

causes, 3-44.

diagnosis, 745.

prognosis, 745.

morbid anatomy, 746.

pathology, 746.

treatment, 746.
Neuralgia of fifth pair of nerves, 739.

symptoms, 739.

causes, 741.

diagnosis, 742.

prognosis, 742.
Neuralgia, cervico-brachial, 743.

cervico-occipital, 743,

crural, 745.

dorso-intercostal, 744.

lumbo-abdominal, 745.

sciatic, 745.

Obliteration of cerebral arteries, 119.
Organic dementia, 337.
Organic infantUe paralysis, 689.

symptoms, 689.

causes, 691.

diagnosis, 691.

prognosis, 691.

morbid anatomy, 692.

pathology, 695.

treatment, 696.

Paralysis agitans, 706.

symptoms, 707.

causes, 708.

diagnosis, 708.

prognosis, 708.

morbid anatomy, 709.

pathology, 709.

treatment, 710.
Paralysis, general, 338, 366.

infantile, 6S9.

inhibitory, 431.

reflex, 431.

facial, 722.

lead, 715.

peripheral, 722.
Paralytic insanity, 337
Partial cerebral anaemia, 119.
48

Passive cerebral congestion, 41.

Bymptoms, 41.

first stage of, 41.

apoplectic form of, 42.

second stage of, 42.

epileptic form of, 42.

maniacal form ot, 42.
Pathetic insanity, 336.
Peripheral anaesthesia, 735.

hyperesthesia, 739.

nerves, diseases of, 721.

paralysis, 722.

spasm, 731.
Perception, 327.
Perceptional insanity, 338, 343.
Posterior columns of spinal cord, anae-
mia ol' 397.
Posterior columns of spinal cord, scle-
rosis of, 484.
Progressive muscular atrophy, 663.

symptoms, 664.

causes, 668.

diagnosis, 670.

prognosis, 670.

morbid anatomy, 670.

pathology, 674.

treatment, 676.

Keflex paralysis, 431.

Sciatic neuralgia, 745.

causes, 745.

diagnosis, 746.

prognosis, 746.
Sclerosis, multiple, cerebral, 278.
Sclerosis, cerebro-spinal, 637.
Sclerosis, diffused cerebral, 260.
Sclerosis of antero-lateral columns of
spinal cord, 471.

symptoms, 471.

causes, 476.

diagnosis, 477.

prognosis, 477.

morbid anatomy, 477.

pathology, 477.

treatment, 482.
Sclerosis of posterior columns of spinal
cord, 484.

symptoms, 484.

causes, 496.

diagnosis, 496.

prognosis, 498.

morbid anatomy, 498.

pathology, 499.

treatment, 513.
Secondary degeneration of spinal cord,
523.

symptoms, 524.
causes, 526.
diagnosis, 526.
prognosis, 526.
morbid anatomy, 527.
pathology, 527.
treatment, 527.

754

INDEX.

Senile dementia, 337.
Senile meningitis, 223.
Simple insanity, 337.
Softening, cerebral, 137.

spinal, 463.
Spasm, peripheral, 731.

facial, 731.

writer's, 710.
Spinal cord, anaemia of posterior col-
umns of, 397.

sclerosis of antero-lateral columns
of, 471.

sclerosis of posterior columns of, 484.

secondary degeneration of, 523.

tumors of, 517.
Spinal aneemiaj 396.
Spinal congestion, 385.

symptoms, 385.

causes, 388.

diagnosis, 389.

prognosis, 390.

morbid anatomy, 391.

pathology, 391.

treatment, 392.
Spinal haemorrhage, 440.
Spinal meningeal haemorrhage, 440.
Spinal irritation, 397.

symptoms, 408.

morbid anatomy, 416.

pathology, 416.

diagnosis, 419.

treatment, 422.
Spinal meningitis, 444.

symptoms, 444.

causes, 44b.

diagnosis, 447.

morbid anatomy, 448.

pathology, 448.

treatment, 448.
Spinal softening, 463.

symptoms, 463.

causes, 467.

diagnosis, 467.

prognosis, 468.

morbid anatomy, 468,

pathology, 468.

treatment, 469.
Suppurative encephalitis, 246.

symptoms, 246.

causes, 251.

diagnosis, 251.

prognosis, 253.

morbid anatomy, 253.

pathology, 253.

treatment, 258.

Tetanus, 529.

symptoms, 529.
causes, 533.
diagnosis, 534.
prognosis, 536.
morbid anatomy, 537.
pathology, 537.
treatment, 539.

Thrombosis, 119.

symptoms, 119.

causes, 121.

prognosis, 122.

diagnosis, 122.

morbid anatomy, 123.
' pathology, 123.

treatment, 126.
Trophic nerve-cellSj atrophy and dis-

ai^pearance ot, 603.
Tubercular cerebral meningitis, 234.

symptoms, 234.

causes, 240.

diagnosis, 241.

prognosis, 242.

morbid anatomy, 242.

pathology, 242.

treatment, 244.
Torticollis, 733.

symptoms, 733. ,

causes, 733.

diagnosis, 733.

prognosis, 733.

morbid anatomy, 733.

pathology, 733.

treatment, 733.
Tumors of the brain, 301.

symptoms, 301.

causes, 311.

vascular, 311, 315.

parasitic, 312, 317.

diathetic, 312, 319.

tulaerculous, 312, 319.

syphilitic, 312, 320.

accidental, 312, 320.

diagnosis, 313.

prognosis, 315.

morbid anatomy, 315.

fibro-plastic, 320.

osseous, 321.

lipomatous, 321.

enchondromatous, 321.

mucous, 321.

treatment, 322.
Tumors of spinal cord, 517.

symptoms, 517.

causes, 520.

diagnosis, 520.

prognosis, 521.

morbid anatomy, 621.

pathology, 521.

treatment, 521.

Volitional insanity, 338, 357.
Will, 328.

"Writer's spasm, 710.
symptoms, 711.
causes, 713.
diagnosis, 713.
prognosis, 714.
morbid anatomy, 714.
pathology, 714.
treatment, 714.

D. APPLETON dk CO:S PUBLICATIONS.

THE PHYSIOLOGY

AND

PATHOLOGY OF THE Mim

By HENRY MJ^XJDSLEY, M. ID., London..
1 volume, Svo. Cloth. Price, $3.

CONTENTS :

Part I.— The Physiology of the mind.

Chaptbb 1. On the Method of the Study of the Mind.
" 2. The Mind and the Nervous System.

" 3. The Spinal Cord, or Tertiary Nervous Centres ; or, Nervous Centres of Keflex Action.

" 4. Secondary Nervous Centres ; or Sensory Ganglia; Sensorium Commune.

" 5. Hemispherical Ganglia; Cortical Cells of the Cerebral Hemispheres: Ideational

Nervous Centres ; Primary Nervous Centres; Intellectorium Commune.
" 6. The Emotions.
" 7. Volition.

" 8. Motor Nervous Centres, or Motorium Communo and Actuation or Effection.
" 9. Memory and Imagination.

Part II.— The Pathology of the Hind.

Chapteb 1. On the Causes of Insanity. Chapter 4. On the Pathology of Insanity.

«' 2. On the Insanity of Early Life. " 5. On the Diagnosis of Insanity.

« 8. On the Varieties of Insanity. " 6. On the Prognosis of Insanity,

Chapteb T. On the Treatment of Insanity.

" The first part of this work may be considered as embodying the most advanced
expression of the new school in physiological psychology, which has arisen in
Europe, and of which Bain, Spencer, Leycoch, and Carpenter, are the more emment
English representatives." — Home Journal.

" The author has professionally studied all the varieties of insanity, and the
seven chapters he devotes to the subject are invaluable to the physician, and full of
important suggestions to the metaphysician."— ^ostow Transcript.

" In the recital of the causes of insanity, as found in peculiarities of civilization, of
religion, of age, sex, condition, and particularly in the engrossmg pursuit of wealth,
tliis calm, scientific work has the solemnity of a hundred sermons ; and after going
down into this exploration of the mysteries of our being, we shall come up into
active life again chastened, thoughtful, and feeling, perhaps, as we never felt before,
how fearfully and wonderfully we are made." — Evening Gazette

J). AFFLETON db CO:S PUBLICATIONS.

THE PHYSIOLOGY OF MAN;

DESIGNED

TO REPRESENT THE EXISTING STATE OF PHYSIOLOGICAL SCIENCE,
AS APPLIED TO THE FUNCTIONS OF THE HUMAN BODY.

By- AUSTIN mXiIN-T, Jr., JVL. D.

Alimentation ; Digestion ; Absorption ; Lymph and Chyle.

1 volume, 870. Clotli. Price, $4.50.

THE FIRST VOLUME OF THE SERIES

^TTSTIISJ" E^IjIN"T, Jr., M. U.,

CONTAINING

Introduction; The Blood; The Circulation; Respiration.

1 volume, 8vo. Clotli. Price, $4.50.

" Professor Flint is engaged in the preparation of an extended work on human
physiology, in which he professes to consider all the subjects usually regarded as be-
longing to that department of physical science. The work will be divided into
separate and distinct parts, but the, several volumes in which it is to be published
will form a connected series." — Frovidence Journal.

It is free from technicalities and purely professional terms, and instead of only
being adapted to the use of the medical faculty, will be found of interest to the
general reader who desires clear and concise information on the subject of man
physical." — Evening Post.

" Digestion is too little understood, indigestion too extensively suffered, to
render this a work of supererogation. Stomachs will have their revenge, sooner or
later. If Nature's laws are infringed upon through ignorance or stubbornness, and it
is well that all should understand how the penalty for ' high living ' is assessed." —
Cliicago Evening Journal.

" A year has elapsed since Dr. Flint published the first part of his great work
upon human physiology. It was an admirable treatise — distinct in itself— exhaust-
ing the special subjects up«n which it treated." — Philadelphia Inquirer,

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